Detailed information for compound 1439831

Basic information

Technical information
  • TDR Targets ID: 1439831
  • Name: N-(2-amino-1,3-benzothiazol-6-yl)-4-methylben zenesulfonamide
  • MW: 319.402 | Formula: C14H13N3O2S2
  • H donors: 2 H acceptors: 3 LogP: 2.92 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)S(=O)(=O)Nc1ccc2c(c1)sc(n2)N
  • InChi: 1S/C14H13N3O2S2/c1-9-2-5-11(6-3-9)21(18,19)17-10-4-7-12-13(8-10)20-14(15)16-12/h2-8,17H,1H3,(H2,15,16)
  • InChiKey: CNPRDMVXAGQDKX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-amino-1,3-benzothiazol-6-yl)-4-methyl-benzenesulfonamide
  • ZINC00210608
  • BAS 09850447
  • MLS000035130
  • N-(2-Amino-benzothiazol-6-yl)-4-methyl-benzenesulfonamide
  • SMR000015264
  • EU-0049279

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0861 0.1202 0.1202
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0163 0.0175 0.0175
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.1162 0.1162
Loa Loa (eye worm) hypothetical protein 0.1385 0.1974 0.1974
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0645 0.0884 0.0884
Leishmania major phosphatidylinositol 4-kinase, putative 0.0452 0.06 0.0599
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0094 0.0073 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.4064 0.5915 0.5915
Trichomonas vaginalis PIKK family atypical protein kinase 0.1837 0.2638 0.2638
Echinococcus multilocularis rac serine:threonine kinase 0.0094 0.0073 0.0073
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0356 0.0356
Brugia malayi Protein kinase domain containing protein 0.0137 0.0136 0.0136
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0001 0.0001
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0085 0.0061 0.0061
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0512 0.0689 0.0688
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0001 0.0001
Entamoeba histolytica PH domain containing protein kinase, putative 0.0094 0.0073 0.0073
Entamoeba histolytica protein kinase, putative 0.0128 0.0124 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.1312 0.1866 0.1866
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0472 0.0629 0.0629
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0452 0.06 0.06
Echinococcus granulosus voltage gated potassium channel 0.0055 0.0016 0.0016
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0645 0.0884 0.0884
Loa Loa (eye worm) phosphatidylinositol 3 0.2333 0.3368 0.3368
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0492 0.066 0.0659
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0472 0.0629 0.0629
Giardia lamblia GTOR 0.684 1 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0189 0.0214 0.0214
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0452 0.06 0.0599
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0472 0.0629 0.0628
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0472 0.0629 0.0629
Trichomonas vaginalis PIKK family atypical protein kinase 0.583 0.8514 0.8514
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0472 0.0629 0.0629
Trichomonas vaginalis PIKK family atypical protein kinase 0.5449 0.7954 0.7954
Loa Loa (eye worm) hypothetical protein 0.101 0.1421 0.1421
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0452 0.06 0.9481
Trichomonas vaginalis PIKK family atypical protein kinase 0.1312 0.1866 0.1866
Loa Loa (eye worm) phosphatidylinositol 3 0.0061 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.5098 0.7437 0.7437
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.1162 0.1162
Trichomonas vaginalis PIKK family atypical protein kinase 0.3713 0.5399 0.5399
Trichomonas vaginalis PIKK family atypical protein kinase 0.3713 0.5399 0.5399
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.082 0.1142 0.1142
Entamoeba histolytica hypothetical protein 0.1312 0.1866 0.1866
Leishmania major fk506-binding protein 1-like protein 0.0163 0.0175 0.0174
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0452 0.06 0.9481
Trichomonas vaginalis PIKK family atypical protein kinase 0.5098 0.7437 0.7437
Echinococcus multilocularis nervana 2 0.0084 0.0059 0.0059
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.684 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0452 0.06 0.06
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0141 0.0142 0.0142
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0452 0.06 0.0599
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0163 0.0175 0.2016
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0542 0.0732 0.0731
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0163 0.0175 0.2016
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0712 0.0983 0.0983
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.1376 0.1376
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0472 0.0629 1
Brugia malayi FAT domain containing protein 0.101 0.1421 0.1421
Trichomonas vaginalis PIKK family atypical protein kinase 0.4088 0.5951 0.5951
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0645 0.0884 0.0884
Giardia lamblia Kinase, AGC PKA 0.0085 0.0061 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.4064 0.5915 0.5915
Loa Loa (eye worm) phosphatidylinositol 3 0.0452 0.06 0.06
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0189 0.0214 0.0214
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0512 0.0689 0.0689
Echinococcus granulosus microtubule associated protein 2 0.0833 0.1162 0.1162
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0645 0.0884 0.0883
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0177 0.0196 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.3707 0.5391 0.5391
Leishmania major phosphatidylinositol kinase, putative 0.0452 0.06 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.2322 0.3352 0.3352
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0175 0.0193 0.0193
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2373 0.3428 0.3428
Schistosoma mansoni immunophilin 0.0163 0.0175 0.0175
Echinococcus granulosus serine protein kinase ATM 0.1312 0.1866 0.1866
Loa Loa (eye worm) hypothetical protein 0.0575 0.0781 0.0781
Loa Loa (eye worm) glutaminase 2 0.033 0.0421 0.0421
Onchocerca volvulus 0.0452 0.06 1
Loa Loa (eye worm) FKBP5 protein 0.0163 0.0175 0.0175
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0163 0.0175 0.0174
Loa Loa (eye worm) AGC/AKT protein kinase 0.0137 0.0136 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.1462 0.2086 0.2086
Loa Loa (eye worm) hypothetical protein 0.0141 0.0142 0.0142
Echinococcus multilocularis voltage gated potassium channel 0.0055 0.0016 0.0016
Trypanosoma cruzi Protein kinase B 0.0094 0.0073 0.0072
Loa Loa (eye worm) phosphatidylinositol kinase 0.0452 0.06 0.06
Echinococcus granulosus serine threonine protein kinase nrc 0.0085 0.0061 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.101 0.1421 0.1421
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0163 0.0175 0.0174
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1312 0.1866 0.1866
Trichomonas vaginalis PIKK family atypical protein kinase 0.684 1 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0001 0.0001
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1312 0.1866 0.1865
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2373 0.3428 0.3427
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0452 0.06 0.0599
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0055 0.0016 0.0016
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1312 0.1866 0.1866
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2373 0.3428 0.3428
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0512 0.0689 0.0689
Loa Loa (eye worm) phosphatidylinositol 3 0.684 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0512 0.0689 0.0689
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0452 0.06 0.06
Schistosoma mansoni survival motor neuron protein 0.0058 0.0021 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.3707 0.5391 0.5391
Giardia lamblia Hypothetical protein 0.0452 0.06 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.4088 0.5951 0.5951
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0001 0.0001
Schistosoma mansoni voltage-gated potassium channel 0.0055 0.0016 0.0016
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0163 0.0175 0.5
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0356 0.0356
Trypanosoma cruzi target of rapamycin kinase 3 0.5455 0.7962 0.7962
Loa Loa (eye worm) hypothetical protein 0.0861 0.1202 0.1202
Loa Loa (eye worm) phosphatidylinositol 3 0.0452 0.06 0.06
Toxoplasma gondii FATC domain-containing protein 0.1312 0.1866 0.2382
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0472 0.0629 0.0691
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0575 0.0781 0.0781
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0582 0.0792 0.0792
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0163 0.0175 0.0175
Loa Loa (eye worm) phosphatidylinositol 3 0.0452 0.06 0.06
Schistosoma mansoni serine/threonine-protein kinase 0.0094 0.0073 0.0073
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.684 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0055 0.0016 0.0016
Brugia malayi glutaminase DH11.1 0.033 0.0421 0.0421
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.684 1 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0021 0.0021
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0452 0.06 0.06
Schistosoma mansoni voltage-gated potassium channel 0.0207 0.024 0.024
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5455 0.7962 0.7962
Trichomonas vaginalis immunophilin, putative 0.0163 0.0175 0.0175
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0163 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.1312 0.1866 0.1866
Trichomonas vaginalis PIKK family atypical protein kinase 0.5098 0.7437 0.7437
Entamoeba histolytica hypothetical protein 0.0452 0.06 0.06
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0128 0.0124 0.0124
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0472 0.0629 0.0629
Trichomonas vaginalis glutaminase, putative 0.033 0.0421 0.0421
Trichomonas vaginalis AGC family protein kinase 0.0052 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0092 0.0071 0.007
Leishmania major hypothetical protein, unknown function 0.0452 0.06 0.0599
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.082 0.1142 0.1142
Entamoeba histolytica hypothetical protein 0.0452 0.06 0.06
Loa Loa (eye worm) hypothetical protein 0.0286 0.0356 0.0356
Echinococcus granulosus serine/threonine protein kinase 0.0094 0.0073 0.0073
Echinococcus multilocularis 0.0452 0.06 0.06
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.684 1 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0001 0.0001
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0861 0.1202 0.1201
Trypanosoma brucei rac serine-threonine kinase, putative 0.0137 0.0136 0.0135
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0452 0.06 0.0651
Loa Loa (eye worm) hypothetical protein 0.007 0.0039 0.0039
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2322 0.3352 0.3352
Echinococcus multilocularis serine protein kinase ATM 0.1312 0.1866 0.1866
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0452 0.06 0.06
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0452 0.06 0.9481
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0512 0.0689 0.0689
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0472 0.0629 0.0629
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0136 0.0136
Brugia malayi p70 ribosomal S6 kinase beta 0.0128 0.0124 0.0124
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.684 1 1
Loa Loa (eye worm) hypothetical protein 0.0452 0.06 0.06
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2852 0.4132 0.4132
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0163 0.0175 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.2322 0.3352 0.3352
Echinococcus multilocularis Zinc finger, PHD finger 0.0472 0.0629 0.0629
Entamoeba histolytica protein kinase 2, putative 0.0085 0.0061 0.0061
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0084 0.0059 0.0059
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0452 0.06 0.06
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0164 0.0177 0.0177
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0861 0.1202 0.1202
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0512 0.0689 0.0688
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0163 0.0175 0.0175
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0085 0.0061 0.0061
Leishmania major phosphatidylinositol 3-kinase, putative 0.2322 0.3352 0.3352
Trichomonas vaginalis PIKK family atypical protein kinase 0.684 1 1
Leishmania major peptidylprolyl isomerase-like protein 0.0163 0.0175 0.0174
Mycobacterium tuberculosis Conserved hypothetical protein 0.0452 0.06 0.5
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0472 0.0629 0.0691
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0452 0.06 0.0599
Echinococcus granulosus nervana 2 0.0084 0.0059 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.4439 0.6467 0.6467
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0136 0.0136
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.2322 0.3352 0.3352
Plasmodium vivax hypothetical protein 0.0452 0.06 0.9481
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0472 0.0629 0.0628
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0163 0.0175 0.0175
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.684 1 1
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0163 0.0175 0.0174
Leishmania major hypothetical protein, conserved 0.0544 0.0736 0.0735
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2333 0.3368 0.3368
Trichomonas vaginalis PIKK family atypical protein kinase 0.684 1 1
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0136 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.5449 0.7954 0.7954
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3228 0.4684 0.4684
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0472 0.0629 0.0628
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0163 0.0175 0.0175
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0604 0.0824 0.0824
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0163 0.0175 0.0174
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0136 0.0136
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1312 0.1866 0.1865
Entamoeba histolytica PH domain containing protein kinase, putative 0.0094 0.0073 0.0073
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0452 0.06 0.0599
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2333 0.3368 0.3368
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0136 0.0136
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0512 0.0689 0.0689
Trichomonas vaginalis PIKK family atypical protein kinase 0.3713 0.5399 0.5399
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0472 0.0629 0.0629
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1312 0.1866 0.1866
Loa Loa (eye worm) phosphatidylinositol 3 0.0452 0.06 0.06
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0472 0.0629 0.0628
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0512 0.0689 0.0689
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0452 0.06 0.06
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.684 1 1
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0452 0.06 0.9481
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0141 0.0142 0.0142
Schistosoma mansoni voltage-gated potassium channel 0.0207 0.024 0.024
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0645 0.0884 0.0884
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0472 0.0629 0.0629
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0452 0.06 0.06
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1312 0.1866 0.1865
Trichomonas vaginalis PIKK family atypical protein kinase 0.5449 0.7954 0.7954
Leishmania major phosphatidylinositol kinase related protein, putative 0.0452 0.06 0.0599
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1312 0.1866 0.1866
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0163 0.0175 0.0175
Leishmania major phosphatidylinositol 3-kinase, putative 0.0472 0.0629 0.0628
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0001 0.0001
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5455 0.7962 0.7962
Mycobacterium ulcerans glutaminase 0.033 0.0421 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0452 0.06 0.0651
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0136 0.0136
Echinococcus granulosus Glutaredoxin protein 5 0.0084 0.0059 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.4088 0.5951 0.5951
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2373 0.3428 0.3428
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0452 0.06 0.9481
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0512 0.0689 0.0689
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.684 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0534 0.0721 0.0721
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0084 0.0059 0.0059
Entamoeba histolytica hypothetical protein 0.0604 0.0824 0.0824
Echinococcus multilocularis fk506 binding protein 0.0163 0.0175 0.0175
Echinococcus multilocularis nervana 2 0.0084 0.0059 0.0059
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.684 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0452 0.06 0.0651
Schistosoma mansoni immunophilin 0.0141 0.0142 0.0142
Schistosoma mansoni immunophilin 0.0163 0.0175 0.0175
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0472 0.0629 0.0629
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0163 0.0175 0.0174
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0575 0.0781 0.0781
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2373 0.3428 0.3428
Entamoeba histolytica protein kinase, putative 0.0137 0.0136 0.0136
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2373 0.3428 0.3427
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0472 0.0629 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.5449 0.7954 0.7954
Trichomonas vaginalis PIKK family atypical protein kinase 0.2322 0.3352 0.3352
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0472 0.0629 0.0629
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0472 0.0629 0.0629
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0452 0.06 0.0599
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0085 0.0061 0.006
Mycobacterium leprae conserved hypothetical protein 0.0452 0.06 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.5098 0.7437 0.7437
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0163 0.0175 0.0175
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0452 0.06 0.06
Trichomonas vaginalis PIKK family atypical protein kinase 0.5098 0.7437 0.7437
Trichomonas vaginalis PIKK family atypical protein kinase 0.5098 0.7437 0.7437
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0452 0.06 0.06
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0177 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.1462 0.2086 0.2086
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.684 1 1
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0163 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0055 0.0016 0.0016
Trichomonas vaginalis fk506-binding protein, putative 0.0163 0.0175 0.0175
Loa Loa (eye worm) phosphatidylinositol 3 0.0779 0.1082 0.1082
Plasmodium vivax hypothetical protein, conserved 0.0452 0.06 0.9481
Entamoeba histolytica hypothetical protein 0.0452 0.06 0.06
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0163 0.0175 0.0175
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0645 0.0884 0.0884
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0193 0.022 0.022
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.684 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0452 0.06 0.06
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.101 0.1421 0.1421
Trichomonas vaginalis AGC family protein kinase 0.0137 0.0136 0.0136
Schistosoma mansoni hypothetical protein 0.0058 0.0021 0.0021
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1462 0.2086 0.2683
Trichomonas vaginalis PIKK family atypical protein kinase 0.1323 0.1882 0.1882
Trichomonas vaginalis PIKK family atypical protein kinase 0.0452 0.06 0.06
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0712 0.0983 0.0983
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0452 0.06 0.06
Schistosoma mansoni hypothetical protein 0.101 0.1421 0.1421
Schistosoma mansoni glutaminase 0.033 0.0421 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.4589 0.6687 0.6687
Toxoplasma gondii target of rapamycin (TOR), putative 0.5098 0.7437 1
Schistosoma mansoni hypothetical protein 0.0452 0.06 0.06
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0452 0.06 0.06
Entamoeba histolytica protein kinase rad3, putative 0.1312 0.1866 0.1866
Trichomonas vaginalis PIKK family atypical protein kinase 0.5098 0.7437 0.7437
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0472 0.0629 0.0629
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0001 0.0001
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.082 0.1142 0.1142
Schistosoma mansoni fkbp-rapamycin associated protein 0.1312 0.1866 0.1866
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0575 0.0781 0.0781
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0163 0.0175 0.0175
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0582 0.0792 0.0792
Brugia malayi hypothetical protein 0.0286 0.0356 0.0356
Trichomonas vaginalis PIKK family atypical protein kinase 0.3707 0.5391 0.5391
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0061 0.0025 0.0024
Onchocerca volvulus 0.0452 0.06 1
Loa Loa (eye worm) glutaminase 0.033 0.0421 0.0421
Echinococcus multilocularis Glutaredoxin protein 5 0.0084 0.0059 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.3713 0.5399 0.5399
Trichomonas vaginalis PIKK family atypical protein kinase 0.5449 0.7954 0.7954
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0452 0.06 0.0599
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0452 0.06 0.06
Schistosoma mansoni voltage-gated potassium channel 0.0055 0.0016 0.0016
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1312 0.1866 0.1866
Trichomonas vaginalis PIKK family atypical protein kinase 0.2333 0.3368 0.3368
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0055 0.0016 0.0016
Echinococcus granulosus nervana 2 0.0084 0.0059 0.0059
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0452 0.06 0.06
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0163 0.0175 0.0174
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0645 0.0884 0.0883
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0189 0.0214 0.0214
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0001 0.0001
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1323 0.1882 0.1882
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.101 0.1421 0.1421
Schistosoma mansoni serine/threonine-protein kinase 0.0094 0.0073 0.0073
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0189 0.0214 0.0214
Entamoeba histolytica protein kinase, putative 0.0137 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0045 0.0001 0.0001
Giardia lamblia Phosphatidylinositol 4-kinase 0.0452 0.06 0.0599
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0163 0.0175 0.0174

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.5821 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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