Detailed information for compound 1443769

Basic information

Technical information
  • TDR Targets ID: 1443769
  • Name: N-[[(4-propoxybenzoyl)amino]carbamothioyl]thi ophene-2-carboxamide
  • MW: 363.454 | Formula: C16H17N3O3S2
  • H donors: 3 H acceptors: 2 LogP: 4.01 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOc1ccc(cc1)C(=O)NNC(=S)NC(=O)c1cccs1
  • InChi: 1S/C16H17N3O3S2/c1-2-9-22-12-7-5-11(6-8-12)14(20)18-19-16(23)17-15(21)13-4-3-10-24-13/h3-8,10H,2,9H2,1H3,(H,18,20)(H2,17,19,21,23)
  • InChiKey: RPPNZPPBWYVRPQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[[N'-[oxo-(4-propoxyphenyl)methyl]hydrazino]-thioxomethyl]-2-thiophenecarboxamide
  • N-[[(4-propoxybenzoyl)amino]thiocarbamoyl]thiophene-2-carboxamide
  • N-[[(4-propoxyphenyl)carbonylamino]carbamothioyl]thiophene-2-carboxamide
  • ZINC02316520
  • STOCK2S-75600

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus transient receptor potential cation channel, subfamily C, member 4 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens NLR family, pyrin domain containing 3 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein cognate 4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128782 All targets in OG5_128782
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70, related Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70 (Precursor), related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni transient receptor potential channel Get druggable targets OG5_128782 All targets in OG5_128782
Babesia bovis heat shock protein 70 precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Cytosolic HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein C precursor Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium berghei heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii chaperonin protein BiP Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Bip Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein 70 precursor Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus transient receptor potential ion channel A Get druggable targets OG5_128782 All targets in OG5_128782
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii heat shock protein HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis transient receptor potential ion channel A Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein homolog, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Short transient receptor potential channel 5, putative Get druggable targets OG5_128782 All targets in OG5_128782
Loa Loa (eye worm) heat shock 70kDa protein 5 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K05328 transient receptor potential cation channel, subfamily C,, putative Get druggable targets OG5_128782 All targets in OG5_128782
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Transient receptor potential-gamma protein, putative Get druggable targets OG5_128782 All targets in OG5_128782
Plasmodium vivax heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K05328 transient receptor potential cation channel, subfamily C,, putative Get druggable targets OG5_128782 All targets in OG5_128782
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis transient receptor potential gamma protein Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus multilocularis heat shock 70 kda protein 1a Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock protein 70 (HSP70) Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock protein, Hsp70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K09490 heat shock 70kDa protein 5, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum Short transient receptor potential channel 5, putative Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus TRP transient receptor potential channel Get druggable targets OG5_128782 All targets in OG5_128782
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni transient receptor potential channel 4 Get druggable targets OG5_128782 All targets in OG5_128782
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis TRP (transient receptor potential) channel Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus granulosus Heat Shock protein family member hsp 3 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock 70 (HSP70) protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein kDa Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus transient receptor potential gamma protein Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus multilocularis Heat Shock protein family member (hsp 3) Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica 70 kDa heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi Transient-receptor-potential like protein Get druggable targets OG5_128782 All targets in OG5_128782
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis dnaK protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 654 aa 613 aa 51.9 %
Echinococcus multilocularis short transient receptor potential channel 6 transient receptor potential cation channel, subfamily C, member 4 890 aa 799 aa 31.2 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0019 0.0019
Toxoplasma gondii histone deacetylase SIR2 0.0115 0.1421 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0066 0.0066
Schistosoma mansoni transient receptor potential channel 0.012 0.1478 0.1478
Echinococcus multilocularis serotonin transporter 0.0091 0.1102 0.1102
Schistosoma mansoni transient receptor potential channel 0.008 0.0957 0.0957
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0109 0.0109
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0444 0.0444
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0115 0.1421 0.1413
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.6398 0.6398
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0066 0.0066
Echinococcus multilocularis sodium and chloride dependent glycine 0.0015 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0046 0.0511 0.0511
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0768 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0066 0.0066
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0211 0.2673 1
Echinococcus granulosus chromatin regulatory protein sir2 0.0211 0.2673 0.2673
Echinococcus multilocularis transient receptor potential ion channel A 0.0113 0.1395 0.1395
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0066 0.0066
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0066 0.0066
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0066 0.0066
Echinococcus granulosus short transient receptor potential channel 6 0.008 0.0957 0.0957
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0066 0.0602
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0115 0.1421 0.1413
Loa Loa (eye worm) hypothetical protein 0.0015 0.0109 0.0109
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0066 0.0602
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0066 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0066 0.0066
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0109 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0066 0.0066
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0011 0.0054 0.0054
Echinococcus multilocularis chromatin regulatory protein sir2 0.0211 0.2673 0.2673
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0066 0.0066
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0444 0.0444
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0066 0.0066
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0109 0.0109
Schistosoma mansoni cpg binding protein 0.0035 0.0362 0.0362
Schistosoma mansoni transient receptor potential channel 4 0.012 0.1478 0.1478
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0066 0.0066
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0066 0.0066
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0066 0.0066
Treponema pallidum sodium- and chloride- dependent transporter 0.0091 0.1102 0.5
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0019 0.0019
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0211 0.2673 0.2667
Schistosoma mansoni hypothetical protein 0.0205 0.2595 0.2595
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0873 0.0873
Echinococcus multilocularis voltage gated potassium channel 0.0015 0.0098 0.0098
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0066 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0066 0.0066
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0488 0.0488
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0015 0.0109 0.5
Onchocerca volvulus 0.0015 0.0109 0.0989
Loa Loa (eye worm) hypothetical protein 0.0012 0.0066 0.0066
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0066 0.0066
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0066 0.0066
Loa Loa (eye worm) transcriptional regulator 0.0211 0.2673 0.2673
Loa Loa (eye worm) serotonin transporter b 0.0091 0.1102 0.1102
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0047 0.0047
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.077 0.5034
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0444 0.0444
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0211 0.2673 1
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0211 0.2673 1
Brugia malayi transcriptional regulator, Sir2 family protein 0.0211 0.2673 0.2673
Loa Loa (eye worm) hypothetical protein 0.0015 0.0109 0.0109
Mycobacterium ulcerans Sir2-like regulatory protein 0.0115 0.1421 0.5
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0091 0.1102 0.1102
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0019 0.0019
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0015 0.0098 0.0098
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0011 0.0054 0.0054
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0054 0.0054
Brugia malayi nuclear hormone receptor 0.0012 0.0066 0.0066
Schistosoma mansoni transient receptor potential channel 0.008 0.0957 0.0957
Brugia malayi hypothetical protein 0.0043 0.0477 0.0477
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0011 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0768 1 1
Brugia malayi CXXC zinc finger family protein 0.0035 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.0012 0.0066 0.0066
Echinococcus multilocularis cpg binding protein 0.0037 0.0388 0.0388
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0066 0.0066
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0015 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0015 0.0109 0.0109
Toxoplasma gondii histone deacetylase SIR2-like 0.0115 0.1421 1
Leishmania major silent information regulator 2, putative 0.0211 0.2673 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0015 0.0109 0.0109
Echinococcus granulosus transient receptor potential ion channel A 0.0113 0.1395 0.1395
Schistosoma mansoni chromatin regulatory protein sir2 0.0115 0.1421 0.1421
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0054 0.0054
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0015 0.0109 0.0109
Echinococcus granulosus cpg binding protein 0.0037 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.0074 0.0874 0.0874
Loa Loa (eye worm) hypothetical protein 0.0091 0.1102 0.1102
Schistosoma mansoni chromatin regulatory protein sir2 0.0768 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0012 0.0066 0.0066
Echinococcus granulosus hyperpolarization activated cyclic 0.0011 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0043 0.0477 0.0477
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0109 0.0109
Brugia malayi transcriptional regulator, Sir2 family protein 0.0115 0.1421 0.1421
Mycobacterium ulcerans NAD-dependent deacetylase 0.0115 0.1421 0.5
Schistosoma mansoni hypothetical protein 0.0494 0.6398 0.6398
Schistosoma mansoni cpg binding protein 0.0037 0.0388 0.0388
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0066 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0066 0.0066
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0115 0.1421 0.4299
Brugia malayi hypothetical protein 0.0015 0.0109 0.0109
Onchocerca volvulus 0.0035 0.0362 0.3284
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0768 1 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0444 0.0444
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0054 0.0044
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0066 0.0066
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0091 0.1102 0.1102
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0488 0.0488
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0011 0.0054 0.0054
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0211 0.2673 1
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0066 0.0066
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0091 0.1102 0.1102
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0115 0.1421 0.1421
Schistosoma mansoni hypothetical protein 0.0205 0.2595 0.2595
Loa Loa (eye worm) norepinephrine transporter 0.0091 0.1102 0.1102
Schistosoma mansoni chromatin regulatory protein sir2 0.0211 0.2673 0.2673
Echinococcus multilocularis hyperpolarization activated cyclic 0.0011 0.0054 0.0054
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0477 0.0477
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0011 0.0054 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0066 0.0066
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0109 0.0109
Loa Loa (eye worm) sirtuin 4 0.0115 0.1421 0.1421
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0066 0.0066
Brugia malayi nuclear receptor NHR-88 0.0012 0.0066 0.0066
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0054
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0066 0.0066
Plasmodium vivax NAD-dependent deacetylase, putative 0.0115 0.1421 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0115 0.1421 0.1421
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0768 1 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0109 0.0109
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0019 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0066 0.0066
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0098 0.0098
Onchocerca volvulus 0.0091 0.1102 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0428 0.0428
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0115 0.1421 0.4299
Echinococcus granulosus geminin 0.0205 0.2595 0.2595
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0015 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0012 0.0066 0.0066
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0066 0.0066
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.0015 0.0109 0.0109
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0015 0.0109 0.0109
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0091 0.1102 0.1102
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0477 0.0477
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0109 0.0109
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0054 0.0054
Schistosoma mansoni sodium-dependent amino acid transporter 0.0015 0.0109 0.0109
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0011 0.0054 0.0054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0066 0.0066
Plasmodium vivax hypothetical protein, conserved 0.0115 0.1421 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0054 0.0054
Echinococcus granulosus hyperpolarization activated cyclic 0.0011 0.0054 0.0054
Loa Loa (eye worm) transcriptional regulator 0.0115 0.1421 0.1421
Onchocerca volvulus 0.0015 0.0109 0.0989
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0211 0.2673 0.2673
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0066 0.0066
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0015 0.0109 0.0109
Echinococcus multilocularis short transient receptor potential channel 6 0.008 0.0957 0.0957
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0015 0.0109 0.0109
Brugia malayi ecdysteroid receptor 0.0012 0.0066 0.0066
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0211 0.2673 0.2667
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0211 0.2673 1
Brugia malayi transcriptional regulator, Sir2 family protein 0.0115 0.1421 0.1421
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0115 0.1421 1
Echinococcus granulosus serotonin transporter 0.0091 0.1102 0.1102
Schistosoma mansoni sodium/chloride dependent transporter 0.0091 0.1102 0.1102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0066 0.0066
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0211 0.2673 0.2673
Loa Loa (eye worm) hypothetical protein 0.0012 0.0066 0.0066
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0109 0.0109
Onchocerca volvulus 0.0012 0.0066 0.0602
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0015 0.0109 0.0109
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0768 1 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0115 0.1421 0.1413
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0653 0.8485 0.8485
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0046 0.0511 0.0511
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0066 0.0066
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0115 0.1421 0.1413
Echinococcus granulosus sodium and chloride dependent glycine 0.0015 0.0109 0.0109
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0015 0.0109 0.0109
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0768 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0066 0.0066
Echinococcus multilocularis transient receptor potential gamma protein 0.012 0.1478 0.1478
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0015 0.0109 0.0109
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0011 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.0066 0.0066
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0012 0.0066 0.0066
Echinococcus granulosus transient receptor potential gamma protein 0.012 0.1478 0.1478
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0066 0.0066
Entamoeba histolytica hypothetical protein, conserved 0.0115 0.1421 0.4299
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0066 0.0602
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0024 0.0216 0.0216
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0015 0.0109 0.0109
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0011 0.0054 0.0054
Schistosoma mansoni cpg binding protein 0.0037 0.0388 0.0388
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0115 0.1421 0.1421
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0066 0.0066
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0066 0.0066
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0115 0.1421 1
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.012 0.1478 0.1478
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0066 0.0066
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0036 0.038 0.038
Loa Loa (eye worm) transcriptional regulator 0.0115 0.1421 0.1421
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0066 0.0066
Loa Loa (eye worm) solute carrier family 6 member 4 0.0091 0.1102 0.1102
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0047 0.0047
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0034 0.0034
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0066 0.0066
Echinococcus multilocularis short transient receptor potential channel 6 0.008 0.0957 0.0957
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0015 0.0109 0.0109
Schistosoma mansoni chromatin regulatory protein sir2 0.0211 0.2673 0.2673
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0768 1 1
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0115 0.1421 0.5
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0015 0.0109 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0066 0.0066
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0115 0.1421 0.1421
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0768 1 1
Echinococcus granulosus TRP transient receptor potential channel 0.0046 0.0511 0.0511
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0066 0.0066
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0115 0.1421 0.1413
Schistosoma mansoni coup transcription factor 0.0012 0.0066 0.0066
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.036 0.0351
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0015 0.0109 0.0109
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0115 0.1421 0.1421
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0011 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0015 0.0098 0.0098
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0015 0.0109 0.0109
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0015 0.0098 0.0098
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.036 0.0351
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0066 0.0066
Schistosoma mansoni chromatin regulatory protein sir2 0.0211 0.2673 0.2673
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0011 0.0054 0.0044
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0066 0.0066
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0066 0.0066
Schistosoma mansoni sodium/chloride dependent transporter 0.0015 0.0109 0.0109
Schistosoma mansoni 60S ribosomal protein L21 0.001 0.0034 0.0034
Onchocerca volvulus 0.0015 0.0109 0.0989
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0015 0.0109 0.0109
Echinococcus granulosus short transient receptor potential channel 6 0.008 0.0957 0.0957
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0477 0.0477
Echinococcus granulosus voltage gated potassium channel 0.0015 0.0098 0.0098
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0011 0.0054 0.0054
Echinococcus multilocularis hyperpolarization activated cyclic 0.0011 0.0054 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0066 0.0066
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0066 0.0066
Schistosoma mansoni chromatin regulatory protein sir2 0.0115 0.1421 0.1421
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0015 0.0098 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0012 0.0066 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0066 0.0066
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0011 0.0054 0.0054
Giardia lamblia Hypothetical protein 0.0211 0.2673 0.146
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0066 0.0066
Brugia malayi Transient-receptor-potential like protein 0.0046 0.0511 0.0511
Echinococcus granulosus dnaJ subfamily B 0.0494 0.6398 0.6398
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0066 0.0066
Brugia malayi Cyclic-nucleotide gated cation channel 0.0011 0.0054 0.0054
Echinococcus multilocularis geminin 0.0205 0.2595 0.2595
Brugia malayi steroid hormone receptor 0.0012 0.0066 0.0066

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 3.7573 uM PUBCHEM_BIOASSAY: Confirmation dose response assay for compounds that activate transient receptor potential cation channel C4 (TRPC4). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2237, AID2259] ChEMBL. No reference
IC50 (functional) = 2.93 uM PUBCHEM_BIOASSAY: Dose Response confirmation of inhibitors of NALP3 in yeast using a Caspase-1-ASC counter screen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2825, AID2832] ChEMBL. No reference
IC50 (functional) = 8.96 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of inhibitors of NALP3 in yeast using a luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2825, AID2832] ChEMBL. No reference
Potency (functional) 0.6513 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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