Detailed information for compound 1444619

Basic information

Technical information
  • TDR Targets ID: 1444619
  • Name: 3-[2-(2,4-dimethoxyphenyl)-5,7-dimethylpyrazo lo[1,5-a]pyrimidin-6-yl]-1-[4-(4-fluorophenyl )piperazin-1-yl]propan-1-one
  • MW: 517.594 | Formula: C29H32FN5O3
  • H donors: 0 H acceptors: 3 LogP: 4.12 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(c(c1)OC)c1cc2n(n1)c(C)c(c(n2)C)CCC(=O)N1CCN(CC1)c1ccc(cc1)F
  • InChi: 1S/C29H32FN5O3/c1-19-24(11-12-29(36)34-15-13-33(14-16-34)22-7-5-21(30)6-8-22)20(2)35-28(31-19)18-26(32-35)25-10-9-23(37-3)17-27(25)38-4/h5-10,17-18H,11-16H2,1-4H3
  • InChiKey: FAIBDWMZZOWIQP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[2-(2,4-dimethoxyphenyl)-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]-1-[4-(4-fluorophenyl)piperazin-1-yl]propan-1-one
  • 3-[2-(2,4-dimethoxyphenyl)-5,7-dimethyl-6-pyrazolo[1,5-a]pyrimidinyl]-1-[4-(4-fluorophenyl)-1-piperazinyl]propan-1-one
  • C561-1524
  • NCGC00110287-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0041 0.0058 0.0217
Plasmodium vivax hypothetical protein 0.0038 0.003 0.0561
Schistosoma mansoni peptidylglycine monooxygenase 0.0245 0.2619 0.2619
Echinococcus multilocularis serotonin receptor 0.0041 0.0058 0.0058
Schistosoma mansoni amine GPCR 0.0041 0.0058 0.0058
Echinococcus multilocularis sex peptide receptor 0.0041 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0041 0.0058 0.0058
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.0058 0.0058
Brugia malayi hypothetical protein 0.0041 0.0058 0.0217
Echinococcus granulosus biogenic amine 5HT receptor 0.0041 0.0058 0.0058
Onchocerca volvulus 0.0286 0.3136 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0038 0.003 0.011
Toxoplasma gondii target of rapamycin (TOR), putative 0.0038 0.003 0.0354
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0514 0.5313
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0041 0.0058 0.0058
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0038 0.003 0.0561
Echinococcus multilocularis neuropeptide receptor 0.0041 0.0058 0.0058
Echinococcus multilocularis neuropeptide receptor A26 0.0041 0.0058 0.0058
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0078 0.0531 0.1338
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0078 0.0531 0.0531
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.0058 0.0058
Schistosoma mansoni amine GPCR 0.0041 0.0058 0.0058
Brugia malayi G protein-coupled receptor F59B2.13 0.0041 0.0058 0.0217
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0078 0.0531 0.1338
Schistosoma mansoni biogenic amine (5HT) receptor 0.0041 0.0058 0.0058
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0078 0.0531 0.1338
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0041 0.0058 0.0217
Brugia malayi larval opioid receptor 0.0041 0.0058 0.0217
Brugia malayi follicle stimulating hormone receptor 0.0041 0.0058 0.0217
Echinococcus granulosus G protein coupled receptor 139 0.0041 0.0058 0.0058
Echinococcus granulosus somatostatin receptor 0.0041 0.0058 0.0058
Onchocerca volvulus 0.0047 0.0136 0.0433
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0514 0.5313
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0245 0.2619 0.9701
Brugia malayi putative neuropeptide receptor NPR1 0.0041 0.0058 0.0217
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0514 0.5313
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0111 0.0941 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0041 0.0058 0.0058
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0063 0.034 0.3399
Loa Loa (eye worm) hypothetical protein 0.0245 0.2619 0.9701
Giardia lamblia Phosphatidylinositol 4-kinase 0.0063 0.034 0.6178
Onchocerca volvulus 0.0041 0.0058 0.0186
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0078 0.0531 0.6317
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0078 0.0531 0.0531
Schistosoma mansoni neuropeptide F-like receptor 0.0041 0.0058 0.0058
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0041 0.0058 0.0058
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0041 0.0058 0.0058
Mycobacterium tuberculosis Probable DNA-3-methyladenine glycosylase I TagA (tag I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g 0.0167 0.1646 1
Onchocerca volvulus 0.0041 0.0058 0.0186
Schistosoma mansoni dopamine-beta-monooxygenase 0.0464 0.5363 0.5363
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.0058 0.0058
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0041 0.0058 0.0058
Echinococcus granulosus neuropeptide receptor A26 0.0041 0.0058 0.0058
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0041 0.0058 0.0058
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0041 0.0058 0.0058
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0078 0.0531 0.1338
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0078 0.0531 0.1338
Echinococcus granulosus hypothetical protein 0.0041 0.0058 0.0058
Schistosoma mansoni neuropeptide receptor 0.0041 0.0058 0.0058
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0111 0.0941 1
Schistosoma mansoni biogenic amine receptor 0.0041 0.0058 0.0058
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.004 0.0049 0.0215
Brugia malayi G-protein coupled receptor 0.0041 0.0058 0.0217
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Onchocerca volvulus 0.0041 0.0058 0.0186
Brugia malayi Tachykinin-like peptides receptor 99D 0.0041 0.0058 0.0217
Echinococcus granulosus allatostatin A receptor 0.0041 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Leishmania major cathepsin L-like protease 0.0077 0.0514 0.5313
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0041 0.0058 0.0058
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0038 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0514 0.5313
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0038 0.003 0.0561
Echinococcus granulosus neuropeptides capa receptor 0.0041 0.0058 0.0058
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0038 0.003 0.003
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0078 0.0531 0.0531
Schistosoma mansoni amine GPCR 0.0041 0.0058 0.0058
Schistosoma mansoni opsin-like receptor 0.0041 0.0058 0.0058
Onchocerca volvulus 0.0041 0.0058 0.0186
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0041 0.0058 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0514 0.5313
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.0058 0.0058
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0078 0.0531 0.0531
Echinococcus granulosus neuropeptide FF receptor 2 0.0041 0.0058 0.0058
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0111 0.0941 0.0941
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.0058 0.0058
Mycobacterium leprae PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE I TAGA (TAG I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g 0.0167 0.1646 1
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0245 0.2619 0.9701
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0038 0.003 0.011
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0063 0.034 0.3399
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0514 0.5313
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0514 0.5313
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Brugia malayi DOMON domain containing protein 0.0047 0.0136 0.0503
Onchocerca volvulus 0.0041 0.0058 0.0186
Brugia malayi AKH receptor 0.0041 0.0058 0.0217
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Echinococcus granulosus neuropeptides capa receptor 0.0041 0.0058 0.0058
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0041 0.0058 0.0217
Schistosoma mansoni hypothetical protein 0.0041 0.0058 0.0058
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0041 0.0058 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Schistosoma mansoni neuropeptide receptor 0.0041 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Loa Loa (eye worm) hypothetical protein 0.0227 0.2394 0.8866
Leishmania major cathepsin L-like protease 0.0077 0.0514 0.5313
Loa Loa (eye worm) phosphatidylinositol 3 0.0063 0.034 0.1258
Schistosoma mansoni neuropeptide receptor 0.0041 0.0058 0.0058
Schistosoma mansoni neuropeptide f receptor 76f 0.0041 0.0058 0.0058
Loa Loa (eye worm) neuropeptide F receptor 0.0041 0.0058 0.0217
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0038 0.003 0.011
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0111 0.0941 0.0941
Schistosoma mansoni amine GPCR 0.0041 0.0058 0.0058
Echinococcus multilocularis serotonin receptor 0.0041 0.0058 0.0058
Onchocerca volvulus 0.0041 0.0058 0.0186
Loa Loa (eye worm) DOMON domain-containing protein 0.0047 0.0136 0.0503
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0038 0.003 0.003
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0038 0.003 0.011
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0041 0.0058 0.0217
Leishmania major phosphatidylinositol 3-kinase, putative 0.0078 0.0531 0.5502
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Echinococcus multilocularis allatostatin A receptor 0.0041 0.0058 0.0058
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0038 0.003 0.0354
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0103 0.0841 1
Brugia malayi G protein-coupled receptor 0.0041 0.0058 0.0217
Loa Loa (eye worm) phosphatidylinositol 3 0.0227 0.2394 0.8866
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0041 0.0058 0.0217
Schistosoma mansoni myosin xvIII 0.0041 0.0058 0.0058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Echinococcus granulosus neuropeptide s receptor 0.0041 0.0058 0.0058
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0078 0.0531 0.5502
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0111 0.0941 0.0941
Trichomonas vaginalis set domain proteins, putative 0.0286 0.3136 0.8287
Onchocerca volvulus 0.0041 0.0058 0.0186
Schistosoma mansoni biogenic amine receptor 0.0041 0.0058 0.0058
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0071 0.044 0.5228
Onchocerca volvulus 0.0041 0.0058 0.0186
Echinococcus multilocularis neuropeptides capa receptor 0.0041 0.0058 0.0058
Brugia malayi Dopamine receptor 0.0041 0.0058 0.0217
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0058 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0058 0.0058
Echinococcus granulosus tachykinin peptides receptor 99D 0.0041 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Echinococcus multilocularis neuropeptides capa receptor 0.0041 0.0058 0.0058
Echinococcus multilocularis dro:myosuppressin receptor 0.0041 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0058 0.0058
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0227 0.2394 0.2394
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.0058 0.0058
Loa Loa (eye worm) phosphatidylinositol 3 0.0078 0.0531 0.1968
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0514 0.5313
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0041 0.0058 0.0217
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0041 0.0058 0.0058
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0041 0.0058 0.0217
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.0058 0.0058
Echinococcus multilocularis G protein coupled receptor 139 0.0041 0.0058 0.0058
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0041 0.0058 0.0058
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0078 0.0531 0.1338
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0078 0.0531 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0111 0.0941 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0058 0.0058
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0038 0.003 0.0354
Echinococcus multilocularis g-protein coupled receptor 0.0041 0.0058 0.0058
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0063 0.034 0.1258
Echinococcus multilocularis orexin receptor type 2 0.0041 0.0058 0.0058
Schistosoma mansoni biogenic amine (5HT) receptor 0.0041 0.0058 0.0058
Echinococcus multilocularis neuropeptide receptor 0.0041 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.0058 0.0058
Echinococcus granulosus serine protein kinase ATM 0.0038 0.003 0.003
Loa Loa (eye worm) neuropeptide F receptor 0.0041 0.0058 0.0217
Echinococcus granulosus sex peptide receptor 0.0041 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0041 0.0058 0.0058
Echinococcus granulosus neuropeptide Y receptor 0.0041 0.0058 0.0058
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.043 0.4393
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0227 0.2394 0.2394
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0111 0.0941 0.3486
Brugia malayi Serotonin receptor 0.0041 0.0058 0.0217
Echinococcus multilocularis g protein coupled receptor 0.0041 0.0058 0.0058
Brugia malayi hypothetical protein 0.0041 0.0058 0.0217
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Brugia malayi RE15519p 0.0041 0.0058 0.0217
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0111 0.0941 0.3486
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0058 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0058 0.0058
Echinococcus multilocularis G-protein coupled receptor, putative 0.0041 0.0058 0.0058
Brugia malayi DOMON domain containing protein 0.0047 0.0136 0.0503
Onchocerca volvulus 0.0041 0.0058 0.0186
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0038 0.003 0.003
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0078 0.0531 0.5502
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.004 0.0049 0.0215
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0245 0.2619 0.2619
Brugia malayi Pre-SET motif family protein 0.0251 0.27 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0078 0.0531 0.1968
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0514 0.5313
Onchocerca volvulus 0.0041 0.0058 0.0186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0514 0.5313
Echinococcus multilocularis neuropeptide Y receptor 0.0041 0.0058 0.0058
Brugia malayi ORL1-like opioid receptor 0.0041 0.0058 0.0217
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0078 0.0531 0.0531
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0063 0.034 0.034
Schistosoma mansoni alpha-1 adrenergic receptor 0.0041 0.0058 0.0058
Brugia malayi neuropeptide F receptor 0.0041 0.0058 0.0217
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0041 0.0058 0.0058
Echinococcus multilocularis somatostatin receptor 0.0041 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0078 0.0531 0.5502
Brugia malayi hypothetical protein 0.0041 0.0058 0.0217
Brugia malayi putative neuropeptide receptor 0.0041 0.0058 0.0217
Echinococcus multilocularis g protein coupled receptor 0.0041 0.0058 0.0058
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0078 0.0531 0.5502
Brugia malayi G-protein coupled receptor 0.0041 0.0058 0.0217
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0078 0.0531 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0111 0.0941 1
Onchocerca volvulus 0.0041 0.0058 0.0186
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Brugia malayi Dopamine receptor protein 2 0.0041 0.0058 0.0217
Schistosoma mansoni hypothetical protein 0.0038 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0038 0.003 0.011
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0307 0.3044
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0041 0.0058 0.0217
Loa Loa (eye worm) G-protein coupled receptor 0.0041 0.0058 0.0217
Echinococcus multilocularis 0.0063 0.034 0.034
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0111 0.0941 0.2432
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0514 0.5313
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0078 0.0531 0.5502
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0078 0.0531 0.5502
Brugia malayi DOMON domain containing protein 0.0047 0.0136 0.0503
Onchocerca volvulus 0.0227 0.2394 0.7635
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0121 0.1061 0.3928
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0245 0.2619 0.2619
Echinococcus granulosus peptide allatostatin:somatostatin 0.0041 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0078 0.0531 0.1968
Onchocerca volvulus 0.0047 0.0136 0.0433
Loa Loa (eye worm) phosphatidylinositol 3 0.0038 0.003 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0058 0.0058
Schistosoma mansoni amine GPCR 0.0041 0.0058 0.0058
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0078 0.0531 0.1338
Echinococcus granulosus neuropeptide Y receptor 0.0041 0.0058 0.0058
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0078 0.0531 0.5502
Loa Loa (eye worm) hypothetical protein 0.0038 0.003 0.011
Echinococcus granulosus serotonin receptor 0.0041 0.0058 0.0058
Echinococcus multilocularis neuropeptide Y receptor 0.0041 0.0058 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0058 0.0058
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0078 0.0531 0.1968
Echinococcus multilocularis neuropeptide FF receptor 2 0.0041 0.0058 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0514 0.5313
Echinococcus granulosus orexin receptor type 2 0.0041 0.0058 0.0058
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0041 0.0058 0.0186
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Echinococcus multilocularis fmrfamide receptor 0.0041 0.0058 0.0058
Schistosoma mansoni growth hormone secretagogue receptor 0.0041 0.0058 0.0058
Loa Loa (eye worm) DOMON domain-containing protein 0.0047 0.0136 0.0503
Plasmodium vivax hypothetical protein, conserved 0.0038 0.003 0.0561
Brugia malayi Melatonin receptor type 1A 0.0041 0.0058 0.0217
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.0058 0.0058
Brugia malayi hypothetical protein 0.0041 0.0058 0.0217
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0063 0.034 0.3399
Brugia malayi hypothetical protein 0.0041 0.0058 0.0217
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0041 0.0058 0.0058
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0041 0.0058 0.0058
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0041 0.0058 0.0058
Brugia malayi hypothetical protein 0.0041 0.0058 0.0217
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0041 0.0058 0.0058
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Brugia malayi sulfakinin receptor protein 0.0041 0.0058 0.0217
Loa Loa (eye worm) hypothetical protein 0.0245 0.2619 0.9701
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0041 0.0058 0.0058
Onchocerca volvulus 0.0041 0.0058 0.0186
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0038 0.003 0.003
Echinococcus granulosus fmrfamide receptor 0.0041 0.0058 0.0058
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0041 0.0058 0.0058
Schistosoma mansoni fkbp-rapamycin associated protein 0.0038 0.003 0.003
Schistosoma mansoni opsin-like receptor 0.0041 0.0058 0.0058
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0063 0.034 0.6178
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.0058 0.0058
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0041 0.0058 0.0058
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0078 0.0531 0.5502
Echinococcus granulosus neuropeptide receptor 0.0041 0.0058 0.0058
Trichomonas vaginalis DNA-3-methyladenine glycosylase, putative 0.0337 0.3778 1
Onchocerca volvulus 0.0041 0.0058 0.0186
Loa Loa (eye worm) G-protein coupled receptor 0.0041 0.0058 0.0217
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Echinococcus multilocularis g protein coupled receptor 0.0041 0.0058 0.0058
Loa Loa (eye worm) phosphatidylinositol 3 0.0038 0.003 0.011
Onchocerca volvulus 0.0227 0.2394 0.7635
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0038 0.003 0.003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0058 0.0058
Loa Loa (eye worm) phosphatidylinositol kinase 0.0227 0.2394 0.8866
Loa Loa (eye worm) phosphatidylinositol 3 0.0038 0.003 0.011
Echinococcus granulosus alpha 1A adrenergic receptor 0.0041 0.0058 0.0058
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0041 0.0058 0.0217
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Schistosoma mansoni histamine h1 receptor 0.0041 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Loa Loa (eye worm) DOMON domain-containing protein 0.0047 0.0136 0.0503
Toxoplasma gondii FATC domain-containing protein 0.0038 0.003 0.0354
Brugia malayi Dopamine receptor protein 1 0.0041 0.0058 0.0217
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0514 0.5313
Onchocerca volvulus 0.0041 0.0058 0.0186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0514 0.5313
Echinococcus multilocularis Zinc finger, PHD finger 0.0078 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0038 0.003 0.003
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0078 0.0531 0.0531
Echinococcus granulosus 7tm_1 domain containing protein 0.0041 0.0058 0.0058
Brugia malayi GnHR receptor homolog 0.0041 0.0058 0.0217
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0038 0.003 0.003
Loa Loa (eye worm) phosphatidylinositol 3 0.004 0.0049 0.0183
Echinococcus multilocularis serine protein kinase ATM 0.0038 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Schistosoma mansoni biogenic amine receptor 0.0041 0.0058 0.0058
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0063 0.034 0.6392
Echinococcus granulosus g protein coupled receptor 0.0041 0.0058 0.0058
Schistosoma mansoni adenoreceptor 0.0041 0.0058 0.0058
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0078 0.0531 0.0531
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0038 0.003 0.0354
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0124 0.1107 0.4098
Trichomonas vaginalis DNA-3-methyladenine glycosylase, putative 0.0337 0.3778 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Echinococcus granulosus g-protein coupled receptor 0.0041 0.0058 0.0058
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0041 0.0058 0.0217
Mycobacterium ulcerans DNA-3-methyladenine glycosylase I TagA 0.0337 0.3778 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0041 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.27 1
Echinococcus granulosus dro:myosuppressin receptor 0.0041 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Echinococcus granulosus 7TM GPCR rhodopsin 0.0041 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0038 0.003 0.003
Brugia malayi hypothetical protein 0.0041 0.0058 0.0217
Brugia malayi Serotonin receptor 0.0041 0.0058 0.0217
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.0058 0.0058
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0111 0.0941 0.2432
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.0058 0.0058
Brugia malayi hypothetical protein 0.0041 0.0058 0.0217
Schistosoma mansoni neuropeptide receptor 0.0041 0.0058 0.0058
Echinococcus granulosus g protein coupled receptor 0.0041 0.0058 0.0058
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0041 0.0058 0.0058
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0041 0.0058 0.0058
Loa Loa (eye worm) melatonin receptor type 1A 0.0041 0.0058 0.0217
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0041 0.0058 0.0058
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0041 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0227 0.2394 0.2394
Onchocerca volvulus 0.0041 0.0058 0.0186
Schistosoma mansoni hypothetical protein 0.0041 0.0058 0.0058
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0063 0.034 0.034
Leishmania major phosphatidylinositol 4-kinase, putative 0.0063 0.034 0.3399
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0227 0.2394 0.2394
Onchocerca volvulus 0.0041 0.0058 0.0186
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0078 0.0531 0.1338
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0514 0.5313
Brugia malayi neuropeptide F receptor 0.0041 0.0058 0.0217
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0227 0.2394 0.2394
Echinococcus granulosus g protein coupled receptor 0.0041 0.0058 0.0058
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0078 0.0531 0.1338
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.0058 0.0058
Loa Loa (eye worm) TYRA-2 protein 0.0041 0.0058 0.0217
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0038 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0078 0.0531 0.5502
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0041 0.0058 0.0058
Schistosoma mansoni neuropeptide F-like receptor 0.0041 0.0058 0.0058
Loa Loa (eye worm) phosphatidylinositol 3 0.0227 0.2394 0.8866
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0058 0.0058
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.0058 0.0058
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0227 0.2394 0.8866
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0078 0.0531 0.1968
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0245 0.2619 0.2619
Echinococcus multilocularis neuropeptide s receptor 0.0041 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0041 0.0058 0.0058
Entamoeba histolytica hypothetical protein 0.0078 0.0531 0.5502
Onchocerca volvulus Neuropeptide F receptor homolog 0.0041 0.0058 0.0186
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0041 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Leishmania major cathepsin L-like protease 0.0077 0.0514 0.5313
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0038 0.003 0.003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0058 0.0058
Onchocerca volvulus 0.0041 0.0058 0.0186
Echinococcus multilocularis fmrfamide receptor 0.0041 0.0058 0.0058
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0078 0.0531 0.5502
Echinococcus granulosus neuropeptide receptor 0.0041 0.0058 0.0058
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.0058 0.0058
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0038 0.003 0.003
Schistosoma mansoni opsin-like receptor 0.0041 0.0058 0.0058
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0078 0.0531 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0058 0.0217
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0058 0.0058
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0078 0.0531 0.0531
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0227 0.2394 0.8866
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0041 0.0058 0.0217
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.0058 0.0058
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0111 0.0941 1
Brugia malayi hypothetical protein 0.0041 0.0058 0.0217

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) = 3.5481 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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