TDR Targets

Basic information

Technical information

TDR Targets ID: 1445253
Name: MLS000096697
MW: 352.453 | Formula: C19H20N4OS
H donors: 1 H acceptors: 3 LogP: 3.53 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CNC(=O)CSc1nnc(n1c1ccccc1)CCc1ccccc1
InChi: 1S/C19H20N4OS/c1-20-18(24)14-25-19-22-21-17(13-12-15-8-4-2-5-9-15)23(19)16-10-6-3-7-11-16/h2-11H,12-14H2,1H3,(H,20,24)
InChiKey: YBWBYZYGHHPGEW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-methyl-2-{[4-phenyl-5-(2-phenylethyl)-4H-1,2,4-triazol-3-yl]thio}acetamide
SMR000073936
ST5435992
AO-080/41821110
ZINC01140800

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	l(3)mbt-like 1 (Drosophila)	Starlite/ChEMBL	No references
Homo sapiens	bromodomain adjacent to zinc finger domain, 2B	Starlite/ChEMBL	No references
Homo sapiens	glucosidase, alpha	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K01187 alpha-glucosidase [EC3.2.1.20], putative	Get druggable targets OG5_127055	All targets in OG5_127055
Onchocerca volvulus		Get druggable targets OG5_127055	All targets in OG5_127055
Brugia malayi	Bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	Cleft lip and palate transmembrane protein 1-like protein, putative	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus granulosus	endonuclease exonuclease phosphatase	Get druggable targets OG5_130415	All targets in OG5_130415
Echinococcus multilocularis	endonuclease exonuclease phosphatase	Get druggable targets OG5_130415	All targets in OG5_130415
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	Lethal(3)malignant brain tumor-like 4 protein, putative	Get druggable targets OG5_130415	All targets in OG5_130415
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	Lethal(3)malignant brain tumor-like 3 protein, putative	Get druggable targets OG5_130415	All targets in OG5_130415
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	Lysosomal alpha-glucosidase precursor, putative	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus granulosus	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Brugia malayi	Glycosyl hydrolases family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_130415	All targets in OG5_130415
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma mansoni	bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	Conserved hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	ko:K01549 ATP synthase [EC3.6.3.14], putative	Get druggable targets OG5_131570	All targets in OG5_131570
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.0107
Echinococcus granulosus	fetal alzheimer antigen falz	0.0027	0.0069	0.0069
Schistosoma mansoni	coup transcription factor	0.003	0.0124	0.0124
Brugia malayi	PHD-finger family protein	0.003	0.0124	0.0108
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.003	0.0124	0.0107
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.0107
Echinococcus multilocularis	dna polymerase eta	0.0044	0.0383	0.0383
Echinococcus multilocularis	ecdysone induced protein 78C	0.003	0.0124	0.0124
Leishmania major	DNA polymerase eta, putative	0.0031	0.0134	0.0118
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0044	0.0386	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.1192	0.1177
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0027	0.0069	0.0069
Echinococcus granulosus	dna polymerase eta	0.0044	0.0383	0.0383
Schistosoma mansoni	hypothetical protein	0.0165	0.2721	0.2721
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0542	1	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0386	1
Schistosoma mansoni	hypothetical protein	0.0025	0.0025	0.0025
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0124	0.0107
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0405	0.7358	0.7358
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0542	1	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0402	0.0386
Echinococcus multilocularis	geminin	0.0165	0.2721	0.2721
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0066	0.0809	0.0794
Brugia malayi	ImpB/MucB/SamB family protein	0.0044	0.0383	0.0367
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.0107
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0066	0.0809	0.0809
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0044	0.0386	0.037
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0386	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0218	0.0218
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0402	0.0386
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.003	0.0124	0.0124
Leishmania major	alpha glucosidase II subunit, putative	0.0044	0.0386	0.037
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.003	0.0124	0.0107
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.0107
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0732	0.0732
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0124	0.0107
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.003	0.0124	0.0124
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0044	0.0386	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0218	0.0187
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0218	0.0218
Brugia malayi	nuclear receptor NHR-88	0.003	0.0124	0.0107
Loa Loa (eye worm)	mbt repeat family protein	0.0058	0.0655	0.064
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0732	0.0716
Echinococcus granulosus	neutral alpha glucosidase AB	0.0044	0.0386	0.0386
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0386	0.037
Trypanosoma brucei	DNA polymerase eta, putative	0.0044	0.0383	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0493	0.0477
Echinococcus granulosus	transcription factor Dp 1	0.0314	0.5596	0.5596
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0386	0.037
Giardia lamblia	Flap structure-specific endonuclease	0.0025	0.0032	0.5
Echinococcus multilocularis	flap endonuclease 1	0.0025	0.0032	0.0032
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0058	0.0655	0.0655
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0043	0.0381	0.0381
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0402	0.0402
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0402	0.0402
Onchocerca volvulus		0.0114	0.1739	1
Echinococcus granulosus	ecdysone induced protein 78C	0.003	0.0124	0.0124
Schistosoma mansoni	nuclear hormone receptor	0.003	0.0124	0.0124
Echinococcus granulosus	histone acetyltransferase MYST2	0.0066	0.0809	0.0809
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.003	0.0124	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0438	0.0422
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.003	0.0124	0.0107
Echinococcus multilocularis	FTZ F1 alpha	0.003	0.0124	0.0124
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0066	0.0809	0.0809
Entamoeba histolytica	hypothetical protein	0.0035	0.0218	0.0187
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0025	0.0032	0.0016
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.003	0.0124	0.0107
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0542	1	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.003	0.0124	0.0124
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.0107
Brugia malayi	steroid hormone receptor	0.003	0.0124	0.0107
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.0386	0.0355
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.003	0.0124	0.0107
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0732	0.0732
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.003	0.0124	0.0107
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0025	0.0032	0.0016
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.003	0.0124	0.0124
Brugia malayi	ecdysteroid receptor	0.003	0.0124	0.0107
Echinococcus multilocularis	polycomb protein SCMH1	0.0058	0.0655	0.0655
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0072	0.0935	0.0935
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.003	0.0124	0.0124
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0402	0.0402
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.003	0.0124	0.0107
Trypanosoma cruzi	DNA polymerase eta, putative	0.0044	0.0383	0.0367
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.334	0.334
Leishmania major	DNA polymerase eta, putative	0.0044	0.0383	0.0367
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0066	0.0809	0.0809
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0031	0.0134	0.3173
Schistosoma mansoni	sex comb on midleg homolog	0.0058	0.0655	0.0655
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0044	0.0386	0.037
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.0386	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0402	0.0402
Trypanosoma cruzi	DNA polymerase eta, putative	0.0031	0.0134	0.0118
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0124	0.0107
Brugia malayi	Bromodomain containing protein	0.0091	0.1291	0.1277
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0124	0.0124
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.0107
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0197	0.334	0.3329
Loa Loa (eye worm)	steroid hormone receptor	0.003	0.0124	0.0107
Brugia malayi	Nuclear hormone receptor-like 1	0.003	0.0124	0.0107
Schistosoma mansoni	retinoic acid receptor RXR	0.0421	0.7665	0.7665
Schistosoma mansoni	RAR-like nuclear receptor	0.003	0.0124	0.0124
Onchocerca volvulus		0.0058	0.0655	0.329
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0044	0.0386	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0732	0.0716
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0058	0.0655	0.329
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.003	0.0124	0.0107
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.003	0.0124	0.0124
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.003	0.0124	0.0107
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0025	0.0032	0.0424
Loa Loa (eye worm)	PHD-finger family protein	0.0025	0.0025	0.0008
Echinococcus granulosus	polycomb protein SCMH1	0.0058	0.0655	0.0655
Schistosoma mansoni	sex comb on midleg homolog	0.0058	0.0655	0.0655
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0402	0.0402
Schistosoma mansoni	steroid hormone receptor ad4bp	0.003	0.0124	0.0124
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.003	0.0124	0.0124
Schistosoma mansoni	bromodomain containing protein	0.0076	0.1018	0.1018
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0542	1	1
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0058	0.0655	0.0655
Entamoeba histolytica	hypothetical protein	0.0035	0.0218	0.0187
Brugia malayi	Flap endonuclease-1	0.0025	0.0032	0.0016
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0402	0.0402
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.003	0.0124	0.0124
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0732	0.0716
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.003	0.0124	0.0124
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0732	0.0732
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0227	0.3924	0.3924
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0124	0.0124
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.0386	1
Brugia malayi	Steroid receptor seven-up type 2	0.003	0.0124	0.0107
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0732	0.0716
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.003	0.0124	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0538	0.0522
Schistosoma mansoni	hypothetical protein	0.0165	0.2721	0.2721
Loa Loa (eye worm)	MBCTL1	0.0066	0.0809	0.0794
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0542	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0732	0.0732
Trypanosoma brucei	glucosidase, putative	0.0044	0.0386	0.037
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0542	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0124	0.0124
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0218	0.0218
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0124	0.0107
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0542	1	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.0107
Echinococcus granulosus	lysosomal alpha glucosidase	0.0197	0.334	0.334
Loa Loa (eye worm)	hypothetical protein	0.003	0.0124	0.0107
Echinococcus granulosus	FTZ F1 alpha	0.003	0.0124	0.0124
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0066	0.0809	0.0809
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0124	0.0107
Brugia malayi	photoreceptor-specific nuclear receptor	0.003	0.0124	0.0107
Brugia malayi	RNA binding protein	0.0062	0.0732	0.0716
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.003	0.0124	0.0107
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.003	0.0124	0.0124
Brugia malayi	mbt repeat family protein	0.0058	0.0655	0.064
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.0386	0.0355
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0043	0.0381	0.0381
Loa Loa (eye worm)	flap endonuclease-1	0.0025	0.0032	0.0016
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.003	0.0124	0.0107
Schistosoma mansoni	hypothetical protein	0.035	0.63	0.63
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0025	0.0032	0.0016
Brugia malayi	TAR-binding protein	0.0062	0.0732	0.0716
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0124	0.0124
Schistosoma mansoni	alpha glucosidase	0.0044	0.0386	0.0386
Echinococcus granulosus	SAM and MBT domain containing protein	0.0058	0.0655	0.0655
Schistosoma mansoni	thyroid hormone receptor	0.003	0.0124	0.0124
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0072	0.0935	0.0935
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0421	0.7665	0.7665
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0197	0.334	0.3329
Entamoeba histolytica	hypothetical protein	0.0035	0.0218	0.0187
Echinococcus granulosus	flap endonuclease 1	0.0025	0.0032	0.0032
Schistosoma mansoni	alpha-glucosidase	0.0169	0.2811	0.2811
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0542	1	1
Echinococcus granulosus	geminin	0.0165	0.2721	0.2721
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.003	0.0124	0.0124
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.003	0.0124	0.0107
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0732	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0655	0.064
Echinococcus multilocularis	thyroid hormone receptor alpha	0.003	0.0124	0.0124
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0732	0.0732
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0386	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0809	0.0794
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0732	0.0732
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0227	0.3924	0.3924
Brugia malayi	hypothetical protein	0.0035	0.0218	0.0202
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0218	0.0218
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.003	0.0124	0.0124
Schistosoma mansoni	DNA polymerase eta	0.0044	0.0383	0.0383
Brugia malayi	nuclear hormone receptor	0.003	0.0124	0.0107
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.334	0.334
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0383	0.0367
Schistosoma mansoni	alpha-glucosidase	0.0169	0.2811	0.2811
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0386	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0124	0.0107
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0402	0.0402
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0027	0.0069	0.0069
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.0386	1
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0044	0.0386	0.0386
Brugia malayi	mbt repeat family protein	0.0058	0.0655	0.064
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.003	0.0124	0.0124
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0542	1	1
Brugia malayi	Bromodomain containing protein	0.0046	0.0436	0.042
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.003	0.0124	0.0124
Echinococcus multilocularis	transcription factor Dp 1	0.0314	0.5596	0.5596
Schistosoma mansoni	thyroid hormone receptor	0.003	0.0124	0.0124
Plasmodium falciparum	flap endonuclease 1	0.0025	0.0032	1
Plasmodium vivax	flap endonuclease 1, putative	0.0025	0.0032	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.2589 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	= 3.1623 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ]	ChEMBL.	No reference
Potency (functional)	= 3.1623 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	= 6.3096 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1595628

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1445253