Detailed information for compound 1448425

Basic information

Technical information
  • TDR Targets ID: 1448425
  • Name: N-(3-fluorophenyl)-2-[methyl-[2-(4-propanoylp henoxy)acetyl]amino]acetamide
  • MW: 372.39 | Formula: C20H21FN2O4
  • H donors: 1 H acceptors: 3 LogP: 2.58 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)c1ccc(cc1)OCC(=O)N(CC(=O)Nc1cccc(c1)F)C
  • InChi: 1S/C20H21FN2O4/c1-3-18(24)14-7-9-17(10-8-14)27-13-20(26)23(2)12-19(25)22-16-6-4-5-15(21)11-16/h4-11H,3,12-13H2,1-2H3,(H,22,25)
  • InChiKey: ZIVZNDKTKSHCLO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-fluorophenyl)-2-[methyl-[1-oxo-2-[4-(1-oxopropyl)phenoxy]ethyl]amino]acetamide
  • N-(3-fluorophenyl)-2-[methyl-[2-(4-propionylphenoxy)acetyl]amino]acetamide
  • N-(3-fluorophenyl)-2-[methyl-[2-(4-propanoylphenoxy)ethanoyl]amino]ethanamide
  • T5324060
  • ZINC03334500
  • SMR000376674
  • MLS000772058

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans transmembrane alkane 1-monooxygenase AlkB 0.003 0.0403 1
Loa Loa (eye worm) FAT-3 protein 0.003 0.0403 0.0403
Plasmodium falciparum stearoyl-CoA desaturase 0.0225 0.5871 1
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0213 0.0283
Onchocerca volvulus 0.0033 0.0473 0.0112
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0278 0.01
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0537 0.0785
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0278 0.0278
Trypanosoma brucei delta-6 fatty acid desaturase, putative 0.003 0.0403 0.0586
Onchocerca volvulus 0.0033 0.0473 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0213 0.0303
Echinococcus granulosus dna polymerase eta 0.0023 0.0213 0.0213
Mycobacterium ulcerans electron transfer protein FdxB 0.003 0.0403 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0213 0.0213
Schistosoma mansoni ran 0.0026 0.0278 0.0067
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.003 0.0403 0.0292
Echinococcus multilocularis musashi 0.0033 0.0473 0.0473
Brugia malayi Delta5 fatty acid desaturase 0.003 0.0403 0.0608
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0049 0.0049
Toxoplasma gondii sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein 0.003 0.0403 0.4819
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0278 1
Leishmania major delta-5 fatty acid desaturase 0.003 0.0403 0.0292
Trypanosoma brucei fatty acid desaturase, putative 0.0255 0.6715 1
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0352 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0352 0.0213
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.111 0.111
Loa Loa (eye worm) hypothetical protein 0.0032 0.0457 0.0457
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0278 0.0395
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0213 0.0213
Trypanosoma cruzi fatty acid desaturase, putative 0.003 0.0403 0.0292
Plasmodium falciparum importin beta, putative 0.0035 0.0537 0.0462
Schistosoma mansoni lamin 0.0033 0.0473 0.0266
Echinococcus granulosus Sphingolipid delta4 desaturase DES1 0.003 0.0403 0.0403
Trypanosoma brucei delta-4 fatty acid desaturase 0.003 0.0403 0.0586
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.003 0.0403 0.0292
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0278 0.0278
Plasmodium vivax stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative 0.0225 0.5871 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0213 0.0303
Leishmania major delta-6 fatty acid desaturase 0.003 0.0403 0.0292
Brugia malayi intermediate filament protein 0.0033 0.0473 0.0729
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0278 0.01
Echinococcus multilocularis dna polymerase eta 0.0023 0.0213 0.0213
Entamoeba histolytica Ran family GTPase 0.0026 0.0278 0.471
Trypanosoma cruzi fatty acid desaturase, putative 0.0225 0.5871 0.8701
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0213 0.0303
Echinococcus granulosus lamin 0.0033 0.0473 0.0473
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0278 0.04
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0213 0.0303
Leishmania major delta-4 fatty acid desaturase 0.003 0.0403 0.0292
Plasmodium vivax importin-beta 2, putative 0.0035 0.0537 0.0462
Echinococcus multilocularis Peptidase M, neutral zinc metallopeptidases, zinc binding site 0.003 0.0403 0.0403
Leishmania major delta-12 fatty acid desaturase 0.003 0.0403 0.0292
Trichomonas vaginalis ran, putative 0.0026 0.0278 0.471
Trypanosoma brucei cytochrome b5-dependent oleate desaturase 0.003 0.0403 0.0586
Mycobacterium tuberculosis Probable conserved membrane protein 0.003 0.0403 1
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0537 0.0537
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0278 0.0278
Leishmania major importin beta-1 subunit, putative 0.0028 0.0352 0.0213
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0213 0.0303
Schistosoma mansoni importin beta-1 0.0035 0.0537 0.0331
Leishmania major fatty acid desaturase, putative 0.003 0.0403 0.0292
Loa Loa (eye worm) acyl-CoA desaturase 0.0225 0.5871 0.5871
Trypanosoma cruzi fatty acid desaturase, putative 0.0225 0.5871 0.8701
Leishmania major fatty acid desaturase, putative 0.003 0.0403 0.0292
Brugia malayi Fatty acid desaturase family protein 0.003 0.0403 0.0608
Trypanosoma cruzi delta-4 fatty acid desaturase, putative 0.003 0.0403 0.0292
Mycobacterium ulcerans linoleoyl-CoA desaturase, DesA3 0.003 0.0403 1
Trypanosoma cruzi fatty acid desaturase, putative 0.0255 0.6715 1
Loa Loa (eye worm) fatty acid desaturase 0.003 0.0403 0.0403
Echinococcus multilocularis snurportin 1 0.0372 1 1
Onchocerca volvulus 0.0255 0.6715 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0213 0.0303
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0352 1
Leishmania major fatty-acid desaturase, putative 0.0255 0.6715 1
Trypanosoma brucei unspecified product 0.0023 0.0213 0.0303
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0213 0.0303
Brugia malayi RNA, U transporter 1 0.0099 0.234 0.3936
Mycobacterium tuberculosis Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f 0.003 0.0403 1
Echinococcus granulosus lamin dm0 0.0033 0.0473 0.0473
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0473 0.0729
Leishmania major stearic acid desaturase, putative 0.0255 0.6715 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0403 0.0403
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0352 1
Brugia malayi Fatty acid desaturase family protein 0.003 0.0403 0.0608
Echinococcus granulosus importin subunit beta 1 0.0035 0.0537 0.0537
Echinococcus multilocularis Peptidase M, neutral zinc metallopeptidases, zinc binding site 0.003 0.0403 0.0403
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0473 0.0473
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.111 0.0916
Schistosoma mansoni fatty acid desaturase 0.003 0.0403 0.0194
Loa Loa (eye worm) hypothetical protein 0.0035 0.0537 0.0537
Schistosoma mansoni hypothetical protein 0.0372 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.111 0.111
Trypanosoma brucei sphingolipid delta 4 desaturase, putative 0.003 0.0403 0.0586
Loa Loa (eye worm) hypothetical protein 0.0023 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0033 0.0473 0.0473
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.003 0.0403 0.0292
Brugia malayi acyl-CoA desaturase 0.0225 0.5871 1
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0537 1
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0213 0.0283
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.111 0.111
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.111 0.111
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0473 0.0473
Trypanosoma cruzi fatty acid desaturase, putative 0.003 0.0403 0.0292
Echinococcus granulosus dna polymerase kappa 0.0023 0.0213 0.0213
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0213 0.0303
Onchocerca volvulus 0.0255 0.6715 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0213 0.0303
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0213 0.0213
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0213 0.0303
Mycobacterium ulcerans linoleoyl-CoA desaturase, DesA3 0.003 0.0403 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0213 0.0303
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.003 0.0403 1
Mycobacterium ulcerans hypothetical protein 0.003 0.0403 1
Mycobacterium ulcerans hypothetical protein 0.003 0.0403 1
Loa Loa (eye worm) fatty acid desaturase 0.003 0.0403 0.0403
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.111 0.0916
Schistosoma mansoni lamin 0.0033 0.0473 0.0266
Schistosoma mansoni intermediate filament proteins 0.0033 0.0473 0.0266
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.111 0.0916
Echinococcus multilocularis Fatty acid desaturase, type 1 0.003 0.0403 0.0403
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Echinococcus granulosus Fatty acid desaturase type 1 0.003 0.0403 0.0403
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.111 0.1823
Echinococcus multilocularis lamin dm0 0.0033 0.0473 0.0473
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.111 0.111
Mycobacterium ulcerans linoleoyl-CoA desaturase, DesA3_2 0.003 0.0403 1
Echinococcus multilocularis lamin 0.0033 0.0473 0.0473
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0213 0.0213
Trypanosoma cruzi delta-4 fatty acid desaturase, putative 0.003 0.0403 0.0292
Brugia malayi Importin beta-1 subunit 0.0035 0.0537 0.0838
Schistosoma mansoni ran 0.0026 0.0278 0.0067
Echinococcus granulosus intermediate filament protein 0.0033 0.0473 0.0473
Trypanosoma cruzi sphingolipid delta 4 desaturase, putative 0.003 0.0403 0.0292
Entamoeba histolytica hypothetical protein 0.0028 0.0352 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0213 0.0303
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.003 0.0403 0.0292
Trypanosoma cruzi cytochrome b5-dependent oleate desaturase 0.003 0.0403 0.0292
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0213 0.0303
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0213 0.0303
Leishmania major GTP-binding protein, putative 0.0026 0.0278 0.01
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0537 0.0785

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1585 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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