Detailed information for compound 1453987

Basic information

Technical information
  • TDR Targets ID: 1453987
  • Name: (E)-N-[(2,4-dichlorophenyl)carbamothioyl]-3-( 4-morpholin-4-ylsulfonylphenyl)prop-2-enamide
  • MW: 500.419 | Formula: C20H19Cl2N3O4S2
  • H donors: 2 H acceptors: 3 LogP: 3.97 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: S=C(Nc1ccc(cc1Cl)Cl)NC(=O)/C=C/c1ccc(cc1)S(=O)(=O)N1CCOCC1
  • InChi: 1S/C20H19Cl2N3O4S2/c21-15-4-7-18(17(22)13-15)23-20(30)24-19(26)8-3-14-1-5-16(6-2-14)31(27,28)25-9-11-29-12-10-25/h1-8,13H,9-12H2,(H2,23,24,26,30)/b8-3+
  • InChiKey: GMEOFONQEQQOKF-FPYGCLRLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(2,4-dichlorophenyl)carbamothioyl]-3-(4-morpholin-4-ylsulfonylphenyl)prop-2-enamide
  • N-[(2,4-dichlorophenyl)carbamothioyl]-3-(4-morpholinosulfonylphenyl)prop-2-enamide
  • (E)-N-[(2,4-dichlorophenyl)carbamothioyl]-3-(4-morpholinosulfonylphenyl)prop-2-enamide
  • N-[[(2,4-dichlorophenyl)amino]-thioxomethyl]-3-(4-morpholinosulfonylphenyl)prop-2-enamide
  • (E)-N-[[(2,4-dichlorophenyl)amino]-thioxomethyl]-3-(4-morpholinosulfonylphenyl)prop-2-enamide
  • N-[(2,4-dichlorophenyl)thiocarbamoyl]-3-(4-morpholinosulfonylphenyl)acrylamide
  • (E)-N-[(2,4-dichlorophenyl)thiocarbamoyl]-3-(4-morpholinosulfonylphenyl)acrylamide
  • MLS000402297
  • SMR000243040
  • T0517-3997
  • ZINC03313734

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus GPCR family 2 0.0073 0.0735 0.1065
Leishmania major hypothetical protein, conserved 0.0038 0.0308 0.3851
Loa Loa (eye worm) hypothetical protein 0.006 0.0576 0.1815
Loa Loa (eye worm) hypothetical protein 0.0036 0.0288 0.0909
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0072 0.0725 0.9107
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0288 0.0899
Entamoeba histolytica phenylalanyl-tRNA synthetase alpha subunit, putative 0.0071 0.0712 0.2406
Brugia malayi jmjC domain containing protein 0.0048 0.0436 0.1364
Schistosoma mansoni nuclear receptor 0.0017 0.0059 0.008
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0358 0.1136
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0021 0.0102 0.1248
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.015 0.1855
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0527 0.1651
Brugia malayi ecdysone receptor 0.0017 0.0059 0.0175
Schistosoma mansoni coup transcription factor 0.0036 0.0288 0.0415
Brugia malayi hypothetical protein 0.0078 0.0795 0.2497
Echinococcus multilocularis cpg binding protein 0.0032 0.0236 0.0233
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0795 1
Brugia malayi nuclear receptor NHR-67 0.0017 0.0059 0.0175
Treponema pallidum fructose-bisphosphate aldolase 0.0246 0.2828 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0072 0.0725 0.1676
Trypanosoma cruzi phenylalanyl-tRNA synthetase alpha chain, putative 0.0071 0.0712 0.8951
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0237
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.2828 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0185
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0072 0.0725 0.1676
Brugia malayi nuclear receptor NHR-88 0.0017 0.0059 0.0175
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0059 0.008
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.012 0.1307 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0185
Brugia malayi nuclear hormone receptor 0.0017 0.0059 0.0175
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0071 0.0712 0.2406
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0059 0.0055
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0288 0.0415
Echinococcus multilocularis peptidase Clp (S14 family) 0.0047 0.0424 0.0421
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0958 0.0954
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0358 0.1129
Loa Loa (eye worm) latrophilin receptor protein 2 0.0073 0.0735 0.2317
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0646 0.0935
Mycobacterium ulcerans hypothetical protein 0.0025 0.015 0.0194
Onchocerca volvulus 0.0109 0.1169 1
Schistosoma mansoni hypothetical protein 0.0079 0.0806 0.1167
Loa Loa (eye worm) jmjC domain-containing protein 0.0048 0.0436 0.1374
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0443 0.064
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0288 0.0899
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0169 0.0522
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0059 0.0055
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.012 0.1307 0.3244
Mycobacterium tuberculosis Conserved protein 0.0038 0.0308 0.0691
Schistosoma mansoni hypothetical protein 0.0073 0.0735 0.1065
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0185
Schistosoma mansoni hypothetical protein 0.0047 0.0422 0.0609
Echinococcus multilocularis Niemann Pick C1 protein 0.0114 0.1228 0.1225
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0075 0.0907
Echinococcus granulosus lamin 0.0026 0.0169 0.0241
Trypanosoma brucei phenylalanyl-tRNA synthetase alpha chain, putative 0.0071 0.0712 0.8951
Echinococcus multilocularis microtubule associated protein 2 0.058 0.6877 0.6876
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0059 0.0055
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0038 0.0441
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0288 0.0909
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0308 0.0957
Schistosoma mansoni hypothetical protein 0.0073 0.0735 0.1065
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0059 0.008
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0038 0.0441
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0073 0.0735 0.2309
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0025 0.0154 0.1898
Schistosoma mansoni hypothetical protein 0.0047 0.0422 0.0609
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0059 0.0175
Onchocerca volvulus 0.0038 0.0308 0.2367
Brugia malayi tailless protein 0.0017 0.0059 0.0175
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0443 0.1397
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0338 0.3948 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.015 0.0473
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0288 0.0909
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.2828 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0288 0.0415
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0288 0.0415
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.015 0.039
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0358 0.4481
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0288 0.0415
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0308 0.3851
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0288 0.0415
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0308 0.0957
Loa Loa (eye worm) hypothetical protein 0.0038 0.0308 0.0971
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0059 0.0185
Plasmodium falciparum phenylalanine--tRNA ligase 0.0021 0.0102 0.1248
Echinococcus multilocularis protein dispatched 1 0.0056 0.0527 0.0523
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0308 0.0957
Schistosoma mansoni thyroid hormone receptor 0.0036 0.0288 0.0415
Schistosoma mansoni hypothetical protein 0.0073 0.0735 0.1065
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0276 0.0273
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0038 0.0035
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0358 0.1136
Echinococcus granulosus tar DNA binding protein 0.0065 0.0646 0.0935
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0079 0.0806 0.1167
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0646 0.0935
Schistosoma mansoni hypothetical protein 0.0205 0.233 0.3385
Brugia malayi hypothetical protein 0.0079 0.0806 0.2531
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0288 0.0899
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0059 0.008
Loa Loa (eye worm) hypothetical protein 0.0036 0.0288 0.0909
Onchocerca volvulus 0.0056 0.0527 0.4305
Echinococcus granulosus lysine specific demethylase 5A 0.0048 0.0436 0.0629
Schistosoma mansoni transcription factor LCR-F1 0.0079 0.0806 0.1167
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0185
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0288 0.2191
Brugia malayi TAR-binding protein 0.0065 0.0646 0.2027
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0023 0.006
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0083 0.0116
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0263
Schistosoma mansoni nuclear receptor 0.0017 0.0059 0.008
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.015 0.0194
Schistosoma mansoni hypothetical protein 0.0205 0.233 0.3385
Echinococcus multilocularis phenylalanyl tRNA synthetase 0.0021 0.0102 0.0099
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0029 0.0206 0.0592
Echinococcus multilocularis survival motor neuron protein 1 0.0273 0.3154 0.3152
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0288 0.0899
Trichomonas vaginalis inositol monophosphatase, putative 0.0029 0.0206 0.0592
Brugia malayi nuclear receptor RXR 0.0019 0.0083 0.0252
Schistosoma mansoni hypothetical protein 0.0047 0.0422 0.0609
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0042 0.0481
Brugia malayi hypothetical protein 0.0019 0.0083 0.0252
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.2127 0.2125
Toxoplasma gondii Ferredoxin-fold anticodon binding domain-containing protein 0.0021 0.0102 0.1248
Brugia malayi intermediate filament protein 0.0026 0.0169 0.0522
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0059 0.0153
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0274 0.3174 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0288 0.0909
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0063 0.0064
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0046 0.0415 0.0412
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0288 0.0899
Loa Loa (eye worm) pigment dispersing factor receptor c 0.023 0.264 0.8319
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0038 0.0051
Loa Loa (eye worm) hypothetical protein 0.0038 0.0308 0.0971
Entamoeba histolytica hypothetical protein 0.0079 0.0806 0.2743
Loa Loa (eye worm) hypothetical protein 0.0049 0.0443 0.1397
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0288 0.0415
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0063 0.0064
Echinococcus multilocularis dnaJ subfamily B 0.0426 0.5009 0.5007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0288 0.0285
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0288 0.0909
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0358 0.4481
Onchocerca volvulus 0.0025 0.015 0.0965
Loa Loa (eye worm) hypothetical protein 0.0073 0.0735 0.2317
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0741 0.1073
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0288 0.0899
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0308 0.0691
Schistosoma mansoni patched 1 0.0049 0.0443 0.064
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0308 0.3851
Treponema pallidum phenylalanyl-tRNA synthetase subunit alpha 0.0071 0.0712 0.2088
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0079 0.0806 0.0803
Brugia malayi isocitrate dehydrogenase 0.0015 0.0038 0.011
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0288 0.0285
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0358 0.0355
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0358 0.1136
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0795 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0308 0.0691
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0047 0.0424 0.2371
Schistosoma mansoni alpha-glucosidase 0.0162 0.1811 0.2629
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.015 0.0194
Echinococcus multilocularis geminin 0.0205 0.233 0.2327
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0071 0.0712 0.1031
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0059 0.0175
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0358 0.1119
Schistosoma mansoni hypothetical protein 0.0157 0.1759 0.2553
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0288 0.0899
Schistosoma mansoni hypothetical protein 0.0035 0.0276 0.0396
Loa Loa (eye worm) hypothetical protein 0.0016 0.0042 0.0131
Loa Loa (eye worm) hypothetical protein 0.0157 0.1759 0.5541
Onchocerca volvulus 0.0036 0.0288 0.2191
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0288 0.0909
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0038 0.0441
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.2828 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0288 0.0415
Brugia malayi phenylalanyl-tRNA synthetase, mitochondrial precursor, putative 0.0021 0.0102 0.0312
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0026 0.0169 0.0166
Leishmania major phenylalanyl-tRNA synthetase alpha chain, putative 0.0071 0.0712 0.8951
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0073 0.0735 0.0732
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0288 0.0415
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.2828 1
Onchocerca volvulus 0.0038 0.0308 0.2367
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0308 0.0444
Brugia malayi hypothetical protein 0.0273 0.3154 0.9937
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0075 0.0907
Loa Loa (eye worm) jmjC domain-containing protein 0.0012 0.0003 0.0011
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0046 0.0415 0.0599
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0059 0.008
Giardia lamblia Fructose-bisphosphate aldolase 0.0246 0.2828 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0646 0.0935
Loa Loa (eye worm) inositol-1 0.0029 0.0206 0.065
Loa Loa (eye worm) hypothetical protein 0.0038 0.0308 0.0971
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit alpha 0.0338 0.3948 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0029 0.0206 0.2564
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0059 0.008
Echinococcus granulosus FTZ F1 alpha 0.0036 0.0288 0.0415
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0308 0.0305
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0288 0.2191
Echinococcus granulosus expressed conserved protein 0.0107 0.1144 0.166
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0059 0.0055
Schistosoma mansoni hypothetical protein 0.0073 0.0735 0.1065
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0029 0.0206 0.0592
Echinococcus multilocularis phenylalanyl tRNA synthetase alpha chain B 0.0071 0.0712 0.0709
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0646 0.0935
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0308 0.0691
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0042 0.012
Schistosoma mansoni lamin 0.0026 0.0169 0.0241
Brugia malayi hypothetical protein 0.005 0.0461 0.1445
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.0288 0.0285
Loa Loa (eye worm) DR-78 0.0017 0.0059 0.0185
Brugia malayi hypothetical protein 0.0017 0.0059 0.0175
Loa Loa (eye worm) hypothetical protein 0.0038 0.0308 0.0971
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0795 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0358 0.4481
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.015 0.1855
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0646 0.2027
Echinococcus multilocularis inositol monophosphatase 1 0.0029 0.0206 0.0203
Echinococcus multilocularis lysine specific demethylase 5A 0.0046 0.0415 0.0412
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0025 0.0154 0.1898
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0958 0.3017
Brugia malayi jmjC domain containing protein 0.0046 0.0415 0.1299
Loa Loa (eye worm) hypothetical protein 0.0036 0.0288 0.0909
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.2828 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0263
Mycobacterium leprae Probable lipase LipE 0.0038 0.0308 0.1366
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0795 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0288 0.0899
Echinococcus granulosus neuropeptide s receptor 0.0454 0.5342 0.7766
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0038 0.0441
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0025 0.0154 0.0029
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0021 0.0102 0.1248
Brugia malayi conserved hypotetical protein 0.0017 0.0059 0.0175
Echinococcus granulosus intermediate filament protein 0.0026 0.0169 0.0241
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0083 0.0116
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0059 0.0185
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0042 0.0481
Echinococcus granulosus Niemann Pick C1 protein 0.0162 0.1817 0.2639
Schistosoma mansoni phenylalanyl-tRNA synthetase mitochondrial 0.0021 0.0102 0.0144
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0083 0.0263
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0358 0.1136
Brugia malayi steroid hormone receptor 0.0036 0.0288 0.0899
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0263
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0042 0.0481
Brugia malayi CXXC zinc finger family protein 0.003 0.0216 0.0669
Loa Loa (eye worm) hypothetical protein 0.0114 0.1228 0.3868
Brugia malayi AMP-binding enzyme family protein 0.0025 0.015 0.0463
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0059 0.0175
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0288 0.0285
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0308 0.0691
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.2828 1
Echinococcus multilocularis musashi 0.0026 0.0169 0.0166
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0014 0.0024 0.0021
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0288 0.0415
Loa Loa (eye worm) beta-lactamase 0.0038 0.0308 0.0971
Mycobacterium ulcerans beta-lactamase 0.0038 0.0308 0.0602
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0029 0.0206 0.2564
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0014 0.0024 0.003
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0646 0.0935
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0741 0.1719
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0029 0.0206 0.0592
Toxoplasma gondii ABC1 family protein 0.0038 0.0308 0.3851
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0358 0.4481
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0185
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0038 0.0035
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0115 0.1249 0.1812
Loa Loa (eye worm) hypothetical protein 0.0072 0.0725 0.2283
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Mycobacterium tuberculosis Conserved protein 0.0038 0.0308 0.0691
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0358 0.1136
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0288 0.0285
Brugia malayi hypothetical protein 0.0019 0.0083 0.0252
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.015 0.0194
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0047 0.0424 0.0988
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0308 0.0957
Brugia malayi Inositol-1 0.0029 0.0206 0.064
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0185
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0059 0.0055
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0308 0.0691
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.2759 0.6958
Loa Loa (eye worm) hypothetical protein 0.0038 0.0308 0.0971
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0038 0.0121
Schistosoma mansoni inositol monophosphatase 0.0029 0.0206 0.0295
Echinococcus granulosus lamin dm0 0.0026 0.0169 0.0241
Schistosoma mansoni survival motor neuron protein 0.0056 0.0527 0.0761
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.015 0.0194
Echinococcus multilocularis lamin 0.0026 0.0169 0.0166
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0059 0.008
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0059 0.008
Brugia malayi nuclear receptor RXR 0.0017 0.0059 0.0175
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0072 0.0725 0.9107
Brugia malayi phenylalanyl (f) trna synthetase protein 1 0.0071 0.0712 0.2235
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0358 0.1136
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.012 0.1307 0.318
Toxoplasma gondii phenylalanyl-tRNA synthetase alpha chain A, putative 0.0071 0.0712 0.8951
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0443 0.044
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0038 0.0441
Schistosoma mansoni cpg binding protein 0.0032 0.0236 0.0339
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0741 0.1073
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0795 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0288 0.0899
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0958 0.1388
Onchocerca volvulus 0.0026 0.0169 0.113
Brugia malayi ecdysteroid receptor 0.0036 0.0288 0.0899
Onchocerca volvulus 0.0017 0.0059 0.0153
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.023 0.264 0.8317
Mycobacterium ulcerans lipase LipD 0.0038 0.0308 0.0602
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0246 0.2828 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0288 0.0285
Brugia malayi AMP-binding enzyme family protein 0.0025 0.015 0.0463
Echinococcus granulosus phenylalanyl tRNA synthetase 0.0021 0.0102 0.0144
Brugia malayi beta-lactamase family protein 0.0038 0.0308 0.0962
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0358 0.1136
Brugia malayi nuclear receptor NHR-88 0.0036 0.0288 0.0899
Onchocerca volvulus 0.0038 0.0308 0.2367
Onchocerca volvulus 0.0017 0.0059 0.0153
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0017 0.0059 0.0153
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit 0.0071 0.0712 0.8951
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0185
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0741 0.1797
Loa Loa (eye worm) RNA binding protein 0.0065 0.0646 0.2036
Brugia malayi RNA binding protein 0.0065 0.0646 0.2027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0443 0.1442
Schistosoma mansoni hypothetical protein 0.0047 0.0422 0.0609
Echinococcus multilocularis thyroid hormone receptor alpha 0.0036 0.0288 0.0285
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0059 0.008
Brugia malayi Probable ClpP-like protease 0.0072 0.0725 0.2274
Brugia malayi beta-lactamase family protein 0.0038 0.0308 0.0962
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0308 0.0691
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0059 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0308 0.3851
Brugia malayi latrophilin 2 splice variant baaae 0.0157 0.1759 0.5536
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0059 0.008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0038 0.0035
Brugia malayi CHE-14 protein 0.0049 0.0443 0.1387
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0308 0.0444
Trypanosoma brucei glucosidase, putative 0.0042 0.0358 0.4481
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0038 0.0051
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0038 0.011
Schistosoma mansoni jumonji/arid domain-containing protein 0.0048 0.0436 0.0629
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0358 0.1136
Schistosoma mansoni lamin 0.0026 0.0169 0.0241
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0072 0.0725 0.4965
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0646 0.2036
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.0288 0.2191
Echinococcus multilocularis neuropeptide s receptor 0.0454 0.5342 0.534
Brugia malayi hypothetical protein 0.0017 0.0059 0.0175
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0029 0.0206 0.2564
Schistosoma mansoni jumonji domain containing protein 0.0046 0.0415 0.0599
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0038 0.0441
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0288 0.0899
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0063 0.0064
Loa Loa (eye worm) hypothetical protein 0.0036 0.0288 0.0909
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0006 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0288 0.0899
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.015 0.039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0263
Echinococcus multilocularis GPCR, family 2 0.0073 0.0735 0.0732
Mycobacterium tuberculosis Conserved protein 0.0038 0.0308 0.0691
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0246 0.2828 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0288 0.0909
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0288 0.0899
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0288 0.0415
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0169 0.0532
Loa Loa (eye worm) hypothetical protein 0.0078 0.0795 0.2505
Echinococcus multilocularis neuropeptide receptor A26 0.0454 0.5342 0.534
Brugia malayi Latrophilin receptor protein 2 0.0073 0.0735 0.2309
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0026 0.0169 0.0335
Schistosoma mansoni alpha glucosidase 0.0042 0.0358 0.0516
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0059 0.0055
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.015 0.0194
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0063 0.0064
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0288 0.0415
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0072 0.0725 0.0721
Brugia malayi nuclear hormone receptor 0.0036 0.0288 0.0899
Echinococcus multilocularis Niemann Pick C1 protein 0.0162 0.1817 0.1815
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0646 0.0643
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0358 0.0516
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0237
Brugia malayi Calcitonin receptor-like protein seb-1 0.023 0.264 0.8317
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.2828 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0038 0.0441
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0741 0.1719
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0539 0.6769
Loa Loa (eye worm) hypothetical protein 0.0036 0.0288 0.0909
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0958 0.0954
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0083 0.0252
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0308 0.0962
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0185
Schistosoma mansoni thyroid hormone receptor 0.0036 0.0288 0.0415
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0958 0.1388
Brugia malayi AMP-binding enzyme family protein 0.0025 0.015 0.0463
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0216 0.0679
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0185
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0083 0.0252
Loa Loa (eye worm) hypothetical protein 0.0038 0.0308 0.0971
Chlamydia trachomatis phenylalanine--tRNA ligase subunit alpha 0.0338 0.3948 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0276 0.0396
Schistosoma mansoni cpg binding protein 0.0032 0.0236 0.0339
Schistosoma mansoni jumonji/arid domain-containing protein 0.0048 0.0436 0.0629
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0042 0.0481
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0083 0.0116
Schistosoma mansoni microtubule-associated protein tau 0.058 0.6877 1
Plasmodium falciparum phenylalanine--tRNA ligase 0.0021 0.0102 0.1248
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0621 0.0899
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0443 0.064
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0047 0.0424 0.0988
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0237
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0072 0.0725 0.9107
Schistosoma mansoni cpg binding protein 0.003 0.0216 0.0309
Echinococcus granulosus lysosomal alpha glucosidase 0.0188 0.2127 0.309
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0023 0.0071
Mycobacterium ulcerans hypothetical protein 0.0038 0.0308 0.0602
Echinococcus granulosus inositol monophosphatase 1 0.0029 0.0206 0.0295
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.015 0.0194
Echinococcus multilocularis lysosomal alpha glucosidase 0.0188 0.2127 0.2125
Schistosoma mansoni intermediate filament proteins 0.0026 0.0169 0.0241
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0059 0.0175
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0073 0.0735 0.1065
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0246 0.2828 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0075 0.0237
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0072 0.0725 0.1676
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0018
Echinococcus granulosus dnaJ subfamily B 0.0426 0.5009 0.7282
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0059 0.008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0288 0.0899
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0038 0.0441
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0288 0.0415
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.0288 0.0285
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0072 0.0725 0.1676
Brugia malayi Glycosyl hydrolases family 31 protein 0.0188 0.2127 0.6699
Echinococcus granulosus microtubule associated protein 2 0.058 0.6877 1
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0741 0.1073
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0308 0.0444
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0795 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0114 0.1228 0.4256
Echinococcus granulosus phenylalanyl tRNA synthetase alpha chain B 0.0071 0.0712 0.1031
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0185
Schistosoma mansoni zinc finger protein 0.0017 0.0059 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0308 0.3851
Echinococcus granulosus geminin 0.0205 0.233 0.3385
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0073 0.0735 0.0732
Entamoeba histolytica hypothetical protein 0.0079 0.0806 0.2743
Echinococcus granulosus cpg binding protein 0.0032 0.0236 0.0339
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0288 0.0415
Loa Loa (eye worm) hypothetical protein 0.0036 0.0288 0.0909
Schistosoma mansoni peptidase Clp (S14 family) 0.0072 0.0725 0.1049
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0006 0.0002
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0072 0.0725 0.1385
Toxoplasma gondii hypothetical protein 0.0025 0.0154 0.1898
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0288 0.0899
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0288 0.0415
Loa Loa (eye worm) hypothetical protein 0.0071 0.0712 0.2244
Plasmodium vivax phenylalanine--tRNA ligase alpha subunit, putative 0.0071 0.0712 0.8951
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0185
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0263
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0358 0.1136
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0358 0.1136
Loa Loa (eye worm) hypothetical protein 0.0036 0.0288 0.0909
Echinococcus granulosus neuropeptide receptor A26 0.0454 0.5342 0.7766
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0029 0.0206 0.0339
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.015 0.1855
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0038 0.0035
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0741 0.9315
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0958 0.1388
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0038 0.0035
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0185
Loa Loa (eye worm) hypothetical protein 0.0025 0.015 0.0473
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0075 0.0095
Entamoeba histolytica hypothetical protein 0.0079 0.0806 0.2743
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0288 0.0415
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0083 0.008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0163 0.0514
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0029 0.0206 0.2564
Echinococcus granulosus peptidase Clp S14 family 0.0047 0.0424 0.0613
Schistosoma mansoni inositol monophosphatase 0.0029 0.0206 0.0295
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0288 0.0899
Echinococcus multilocularis protein patched 0.0049 0.0443 0.044
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0185
Schistosoma mansoni hypothetical protein 0.0426 0.5009 0.7282
Schistosoma mansoni hypothetical protein 0.0056 0.0527 0.0761
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.015 0.0286
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0073 0.0735 0.1065
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0072 0.0725 0.9107
Onchocerca volvulus 0.003 0.0216 0.1544
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0308 0.0602
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0038 0.0441
Loa Loa (eye worm) hypothetical protein 0.0025 0.015 0.0473
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.015 0.0286
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0288 0.0909
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0188 0.2127 0.6703
Echinococcus multilocularis expressed conserved protein 0.0107 0.1144 0.1141
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0072 0.0725 0.1049
Loa Loa (eye worm) jmjC domain-containing protein 0.0012 0.0003 0.0011
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0021 0.0102 0.0218
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit alpha 0.0338 0.3948 1
Loa Loa (eye worm) phenylalanyl-tRNA synthetase 0.0021 0.0102 0.0322
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0072 0.0725 0.2134
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0795 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0646 0.2036
Brugia malayi follicle stimulating hormone receptor 0.0274 0.3174 1
Loa Loa (eye worm) hypothetical protein 0.0273 0.3154 0.9937
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0169 0.0532
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0029 0.0206 0.2564
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0741 0.1719
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0308 0.1366
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.0288 0.0415
Loa Loa (eye worm) hypothetical protein 0.023 0.264 0.8319
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0021 0.0102 0.0144
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0308 0.0971
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0308 0.0957
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0059 0.0175
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0958 0.3009
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0741 0.9315
Loa Loa (eye worm) hypothetical protein 0.0026 0.0169 0.0532
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.015 0.0194
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0308 0.0691
Brugia malayi Niemann-Pick C1 protein precursor 0.0114 0.1228 0.3861
Brugia malayi beta-lactamase 0.0038 0.0308 0.0962
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Trichomonas vaginalis esterase, putative 0.0038 0.0308 0.0957
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0358 0.1136
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0288 0.0899
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.0288 0.0415
Schistosoma mansoni alpha-glucosidase 0.0162 0.1811 0.2629
Loa Loa (eye worm) jmjC domain-containing protein 0.0012 0.0003 0.0011
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0741 0.0738
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0059 0.0175
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0308 0.0602
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0288 0.0415
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0958 0.1388
Entamoeba histolytica hypothetical protein 0.0079 0.0806 0.2743
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0958 0.1388
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0288 0.0909
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.015 0.039
Mycobacterium leprae Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.005 0.0463 0.2708
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0288 0.0285
Leishmania major hypothetical protein, conserved 0.0078 0.0795 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0059 0.0185
Echinococcus granulosus survival motor neuron protein 1 0.0273 0.3154 0.4583
Echinococcus multilocularis lamin dm0 0.0026 0.0169 0.0166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0288 0.0909
Echinococcus granulosus Niemann Pick C1 protein 0.0114 0.1228 0.1781
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0021 0.0102 0.0218
Onchocerca volvulus 0.0026 0.0169 0.113

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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