Detailed information for compound 1455765

Basic information

Technical information
  • TDR Targets ID: 1455765
  • Name: 3-[(4-methoxyphenyl)amino]-1-methylpyrrole-2, 5-dione
  • MW: 232.235 | Formula: C12H12N2O3
  • H donors: 1 H acceptors: 2 LogP: 1.2 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC1=CC(=O)N(C1=O)C
  • InChi: 1S/C12H12N2O3/c1-14-11(15)7-10(12(14)16)13-8-3-5-9(17-2)6-4-8/h3-7,13H,1-2H3
  • InChiKey: JPMGEMKZBDUYOV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[(4-methoxyphenyl)amino]-1-methyl-pyrrole-2,5-dione
  • 3-[(4-methoxyphenyl)amino]-1-methyl-3-pyrroline-2,5-quinone
  • ZINC04115557
  • AE-473/30364013
  • 1-methyl-3-{[4-(methyloxy)phenyl]amino}-1H-pyrrole-2,5-dione
  • MLS000702224
  • SMR000224740

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0119 0.0272 0.0848
Schistosoma mansoni hypothetical protein 0.0034 0.0023 0.0072
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.0791 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0119 0.0273 0.085
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0422 0.1317
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.0791 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0272 0.0848
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0272 0.3105
Loa Loa (eye worm) hypothetical protein 0.005 0.007 0.0219
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0002 0.0006
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0277 0.0865
Giardia lamblia Fructose-bisphosphate aldolase 0.0295 0.0791 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0001 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0029 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0106 0.033
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.005 0.0155
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.039 0.1071 0.3176
Schistosoma mansoni intermediate filament proteins 0.0027 0.0002 0.0006
Schistosoma mansoni lipoxygenase 0.0119 0.0273 0.085
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0029 0.009
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0422 0.1317
Echinococcus granulosus intermediate filament protein 0.0027 0.0002 0.0006
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0049 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.0791 1
Onchocerca volvulus 0.0027 0.0002 0.0071
Schistosoma mansoni hypothetical protein 0.0171 0.0426 0.1328
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.009
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0072 0.0225
Echinococcus granulosus lamin dm0 0.0027 0.0002 0.0006
Echinococcus multilocularis muscleblind protein 0.0151 0.0366 0.1142
Schistosoma mansoni hypothetical protein 0.0049 0.0067 0.0208
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.0791 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0023 0.0072
Loa Loa (eye worm) hypothetical protein 0.0051 0.0072 0.0225
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0002 0.0006
Loa Loa (eye worm) acetyltransferase 0.0146 0.0353 0.1101
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.2805 0.875
Schistosoma mansoni Replicative DNA helicase 0.039 0.1071 0.3341
Echinococcus multilocularis protein patched 0.0051 0.0072 0.0225
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0341 0.1063
Schistosoma mansoni lipoxygenase 0.0083 0.0167 0.0521
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0762 0.2379
Entamoeba histolytica hypothetical protein 0.0043 0.005 0.0156
Schistosoma mansoni hypothetical protein 0.0043 0.005 0.0155
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.0791 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.0286 0.0893
Echinococcus multilocularis lamin 0.0027 0.0002 0.0006
Entamoeba histolytica hypothetical protein 0.0043 0.005 0.0156
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.009
Schistosoma mansoni lamin 0.0027 0.0002 0.0006
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0353 0.1101
Brugia malayi intermediate filament protein 0.0027 0.0002 0.0006
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3142 0.9172 0.9169
Onchocerca volvulus 0.0036 0.0029 0.101
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0109 0.0243 0.0652
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.2375 0.741
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0029 0.009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.009
Loa Loa (eye worm) hypothetical protein 0.0151 0.0366 0.1142
Schistosoma mansoni hypothetical protein 0.1115 0.3205 1
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.1115 0.3205 1
Echinococcus granulosus muscleblind protein 0.0151 0.0366 0.1142
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.1115 0.3205 1
Schistosoma mansoni lamin 0.0027 0.0002 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0072 0.0566
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.009
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.0791 1
Echinococcus granulosus geminin 0.0171 0.0426 0.1328
Onchocerca volvulus Huntingtin homolog 0.0124 0.0286 1
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0029 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.0791 1
Schistosoma mansoni hypothetical protein 0.0049 0.0067 0.0208
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0119 0.0273 0.085
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.0791 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.005 0.0155
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0049 0.0258
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0029 0.009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.0791 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0049 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0353 0.1101
Schistosoma mansoni hypothetical protein 0.0171 0.0426 0.1328
Loa Loa (eye worm) hypothetical protein 0.0034 0.0023 0.0072
Brugia malayi hypothetical protein 0.0124 0.0286 0.0893
Treponema pallidum replicative DNA helicase (dnaB) 0.039 0.1071 1
Brugia malayi hypothetical protein 0.0286 0.0762 0.2379
Brugia malayi indoleamine 2,3-dioxygenase 0.1115 0.3205 1
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0762 0.2379
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.007 0.0219
Brugia malayi CHE-14 protein 0.0051 0.0072 0.0225
Onchocerca volvulus 0.0058 0.0093 0.326
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.1115 0.3205 1
Leishmania major hypothetical protein, conserved 0.0036 0.0029 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.007 0.0219
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.007 0.0219
Brugia malayi beta-lactamase 0.0036 0.0029 0.009
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0002 0.0006
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0277 0.0864
Loa Loa (eye worm) hypothetical protein 0.0027 0.0002 0.0006
Treponema pallidum fructose-bisphosphate aldolase 0.0295 0.0791 0.6619
Brugia malayi beta-lactamase family protein 0.0036 0.0029 0.009
Echinococcus granulosus lamin 0.0027 0.0002 0.0006
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0072 0.0225
Schistosoma mansoni patched 1 0.0051 0.0072 0.0225
Entamoeba histolytica hypothetical protein 0.0043 0.005 0.0156
Loa Loa (eye worm) hypothetical protein 0.0286 0.0762 0.2379
Echinococcus granulosus microtubule associated protein 2 0.0833 0.2375 0.741
Onchocerca volvulus Huntingtin homolog 0.0124 0.0286 1
Onchocerca volvulus 0.0027 0.0002 0.0071
Loa Loa (eye worm) hypothetical protein 0.0151 0.0366 0.1142
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0272 0.0848
Schistosoma mansoni hypothetical protein 0.0049 0.0067 0.0208
Brugia malayi MH2 domain containing protein 0.0121 0.0277 0.0864
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0072 0.0225
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0029 0.009
Schistosoma mansoni hypothetical protein 0.1115 0.3205 1
Schistosoma mansoni hypothetical protein 0.0058 0.0093 0.0291
Brugia malayi Muscleblind-like protein 0.0151 0.0366 0.1142
Schistosoma mansoni survival motor neuron protein 0.0058 0.0093 0.0291
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0072 0.0225
Echinococcus multilocularis musashi 0.0027 0.0002 0.0006
Chlamydia trachomatis replicative DNA helicase 0.039 0.1071 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0029 0.009
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.0346 0.0318
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0272 0.0848
Mycobacterium ulcerans recombinase A 0.0109 0.0243 0.2052
Echinococcus multilocularis expressed conserved protein 0.0112 0.0251 0.0782
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.0346 0.3047
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.2375 0.741
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.0606 0.0579
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0029 1
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0353 0.1101
Mycobacterium leprae Conserved hypothetical protein 0.1151 0.331 1
Echinococcus multilocularis protein dispatched 1 0.0058 0.0093 0.0291
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.0791 1
Onchocerca volvulus 0.0036 0.0029 0.101
Loa Loa (eye worm) twinkle helicase 0.0112 0.025 0.078
Echinococcus multilocularis geminin 0.0171 0.0426 0.1328
Echinococcus granulosus expressed conserved protein 0.0112 0.0251 0.0782
Schistosoma mansoni hypothetical protein 0.0049 0.0067 0.0208
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0038 0.5
Entamoeba histolytica hypothetical protein 0.0043 0.005 0.0156
Onchocerca volvulus 0.0036 0.0029 0.101
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.005 0.0155
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0029 0.009
Brugia malayi beta-lactamase family protein 0.0036 0.0029 0.009
Brugia malayi hypothetical protein 0.0043 0.005 0.0155
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0093 0.0291
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0277 0.0864
Loa Loa (eye worm) hypothetical protein 0.0124 0.0286 0.0893
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.0346 0.0968
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0049 0.0258
Echinococcus multilocularis lamin dm0 0.0027 0.0002 0.0006
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0049 0.0152
Mycobacterium ulcerans replicative DNA helicase DnaB 0.039 0.1071 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0049 1
Echinococcus multilocularis muscleblind protein 1 0.0151 0.0366 0.1142
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.039 0.1071 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.0029 0.009

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.5821 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (binding) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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