Detailed information for compound 145767

Basic information

Technical information
  • TDR Targets ID: 145767
  • Name: 4-butoxy-N-[[1-(dimethylamino)cyclohexyl]meth yl]benzamide
  • MW: 332.48 | Formula: C20H32N2O2
  • H donors: 1 H acceptors: 1 LogP: 4.09 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCOc1ccc(cc1)C(=O)NCC1(CCCCC1)N(C)C
  • InChi: 1S/C20H32N2O2/c1-4-5-15-24-18-11-9-17(10-12-18)19(23)21-16-20(22(2)3)13-7-6-8-14-20/h9-12H,4-8,13-16H2,1-3H3,(H,21,23)
  • InChiKey: JFXCAMOZHZSKFS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-butoxy-N-[(1-dimethylaminocyclohexyl)methyl]benzamide
  • T5554507

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus sodium and chloride dependent glycine Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma japonicum ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative Get druggable targets OG5_128673 All targets in OG5_128673
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128673 All targets in OG5_128673
Echinococcus multilocularis sodium and chloride dependent glycine Get druggable targets OG5_128673 All targets in OG5_128673
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma japonicum Sodium-dependent proline transporter, putative Get druggable targets OG5_128673 All targets in OG5_128673
Echinococcus multilocularis sodium and chloride dependent glycine Get druggable targets OG5_128673 All targets in OG5_128673
Echinococcus granulosus sodium and chloride dependent glycine Get druggable targets OG5_128673 All targets in OG5_128673
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma japonicum Sodium- and chloride-dependent glycine transporter 1, putative Get druggable targets OG5_128673 All targets in OG5_128673
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128673 All targets in OG5_128673
Schistosoma japonicum Sodium- and chloride-dependent glycine transporter 1, putative Get druggable targets OG5_128673 All targets in OG5_128673
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0099 0.0281
Echinococcus granulosus sodium and chloride dependent glycine 0.0096 0.0344 0.1947
Brugia malayi MAP kinase sur-1 0.005 0.0159 0.1812
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0331 0.1236
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.023
Echinococcus multilocularis sodium and chloride dependent glycine 0.0096 0.0344 0.0344
Toxoplasma gondii exonuclease III APE 0.0019 0.003 0.0046
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0099 0.0558
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.011 0.109
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0331 0.3291
Plasmodium falciparum peptide deformylase 0.1616 0.6536 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0099 0.0105
Brugia malayi Bromodomain containing protein 0.0028 0.007 0.0801
Echinococcus granulosus cpg binding protein 0.0033 0.0089 0.0505
Mycobacterium tuberculosis Conserved protein 0.0035 0.0099 0.0105
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0126 0.1252
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0227 0.0879 0.6621
Schistosoma mansoni sodium/chloride dependent transporter 0.0096 0.0344 0.1947
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0049 0.0076
Trichomonas vaginalis esterase, putative 0.0035 0.0099 0.098
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0007 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0015 0.0154
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0247 0.0334
Brugia malayi CXXC zinc finger family protein 0.0031 0.0082 0.0932
Plasmodium vivax hypothetical protein, conserved 0.0028 0.007 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0064 0.064
Plasmodium vivax amine transporter, putative 0.0019 0.003 0.0047
Schistosoma mansoni hypothetical protein 0.0336 0.1325 0.7506
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0159 0.0159
Toxoplasma gondii hypothetical protein 0.0019 0.003 0.0047
Toxoplasma gondii hypothetical protein 0.0019 0.003 0.0047
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0331 0.0331
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0096 0.0344 0.259
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.0347
Echinococcus granulosus serotonin transporter 0.0019 0.003 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.011 0.109
Trichomonas vaginalis ran, putative 0.0023 0.0049 0.0491
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0247 0.1401
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.009 0.0508
Mycobacterium tuberculosis Conserved protein 0.0035 0.0099 0.0105
Echinococcus multilocularis geminin 0.0336 0.1325 0.1325
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0231 0.1741
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0059 0.0587
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0083 0.0128
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.003 0.003
Chlamydia trachomatis peptide deformylase 0.1616 0.6536 1
Trichomonas vaginalis set domain proteins, putative 0.0258 0.1006 1
Onchocerca volvulus 0.0011 0.0000000055351 0.000000055013
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0337 0.1327 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0159 0.053
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0099 0.0105
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0102 0.0768
Onchocerca volvulus 0.0019 0.003 0.0303
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0019 0.003 0.0173
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.023
Schistosoma mansoni ap endonuclease 0.0019 0.003 0.0171
Echinococcus granulosus importin subunit beta 1 0.0032 0.0083 0.0472
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.003 0.0173
Plasmodium vivax hypothetical protein, conserved 0.0019 0.003 0.0047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0357 0.202
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0049 0.0079
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0055 0.0101
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0029 0.0286
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.007 0.0399
Brugia malayi beta-lactamase 0.0035 0.0099 0.1122
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.1616 0.6536 1
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0116 0.0116
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0099 0.1122
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.0873 0.1296
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0019 0.003 0.0173
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0107 0.0107
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0072 0.0247 0.0892
Echinococcus granulosus snurportin 1 0.0337 0.1327 0.7518
Plasmodium falciparum importin beta, putative 0.0032 0.0083 0.0128
Brugia malayi Pre-SET motif family protein 0.0227 0.0879 1
Brugia malayi jmjC domain containing protein 0.0093 0.0333 0.3793
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0256 0.1448
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.0047
Trypanosoma brucei Polypeptide deformylase 1 0.0617 0.2466 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.023
Plasmodium vivax peptide deformylase, putative 0.1616 0.6536 1
Schistosoma mansoni chromobox protein 0.0068 0.0231 0.1309
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.0047
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0247 0.0334
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0331 0.3291
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0331 0.3291
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0029 0.0286
Onchocerca volvulus 0.0019 0.003 0.0303
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0064 0.064
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0159 0.0902
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0102 0.0577
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0121 0.1207
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0055 0.0101
Brugia malayi Heterochromatin protein 1 0.0068 0.0231 0.2629
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0135 0.0764
Brugia malayi hypothetical protein 0.0019 0.003 0.0347
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0617 0.2466 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0099 0.098
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0159 0.1582
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0107 0.0609
Trypanosoma brucei protein kinase, putative 0.005 0.0159 0.053
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.007 0.0399
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.1616 0.6536 1
Giardia lamblia PHD finger protein 15 0.0028 0.007 0.1335
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0331 0.1876
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0029 0.0164
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.0347
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0126 0.0126
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0083 0.0218
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0126 0.0714
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0099 0.0099
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0019 0.003 0.0173
Loa Loa (eye worm) hypothetical protein 0.0028 0.007 0.053
Echinococcus granulosus dnaJ subfamily B 0.0445 0.1765 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.0047
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0126 0.0393
Echinococcus granulosus Chromobox protein 3 0.0011 0.0000000055351 0.000000031352
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.003 0.0046
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0099 0.0105
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0029 0.0286
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0331 0.3291
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0159 0.4287
Schistosoma mansoni ran 0.0023 0.0049 0.028
Brugia malayi beta-lactamase family protein 0.0035 0.0099 0.1122
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0099 0.0558
Echinococcus multilocularis dnaJ subfamily B 0.0445 0.1765 0.1765
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0049 0.0079
Onchocerca volvulus 0.0258 0.1006 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0019 0.003 0.0173
Entamoeba histolytica hypothetical protein 0.0026 0.0059 0.1783
Schistosoma mansoni hypothetical protein 0.0337 0.1327 0.7518
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0331 1
Echinococcus multilocularis chromobox protein 1 0.0068 0.0231 0.0231
Brugia malayi beta-lactamase family protein 0.0035 0.0099 0.1122
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0617 0.2466 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0159 0.1582
Brugia malayi CHD4 protein 0.0013 0.0007 0.0082
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0099 0.098
Onchocerca volvulus 0.0035 0.0099 0.098
Brugia malayi jmjC domain containing protein 0.0036 0.0102 0.116
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.023
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0126 0.0147
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0159 0.1582
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0159 0.053
Leishmania major GTP-binding protein, putative 0.0023 0.0049 0.0079
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0231 0.2296
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0159 0.0902
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.009 0.009
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0159 0.053
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.023
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.003 0.0171
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0049 0.0562
Mycobacterium ulcerans lipase LipD 0.0035 0.0099 0.0105
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0099 0.0105
Echinococcus granulosus chromobox protein 1 0.0068 0.0231 0.1309
Onchocerca volvulus 0.0019 0.003 0.0303
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0099 0.0105
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0142 0.1412
Loa Loa (eye worm) hypothetical protein 0.0025 0.0055 0.0412
Echinococcus multilocularis snurportin 1 0.0337 0.1327 0.1327
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0331 0.3291
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0357 0.202
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0000000055351 0.0000000055351
Loa Loa (eye worm) hypothetical protein 0.0049 0.0153 0.1152
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0159 0.053
Schistosoma mansoni ap endonuclease 0.0019 0.003 0.0171
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0099 0.0105
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.1616 0.6536 1
Brugia malayi hypothetical protein 0.0025 0.0055 0.0623
Brugia malayi hypothetical protein 0.0016 0.0019 0.022
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0333 0.0333
Leishmania major polypeptide deformylase-like protein, putative 0.0617 0.2466 1
Trypanosoma cruzi Peptide deformylase 2, putative 0.0617 0.2466 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0055 0.0084
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0247 0.0334
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0126 0.3804
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0331 0.3768
Loa Loa (eye worm) hypothetical protein 0.0032 0.0083 0.0628
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.003 0.0173
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.003 0.0227
Plasmodium vivax SET domain protein, putative 0.0033 0.009 0.0137
Giardia lamblia Kinase, PLK 0.0092 0.0331 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.023
Loa Loa (eye worm) hypothetical protein 0.0035 0.0099 0.0743
Schistosoma mansoni cpg binding protein 0.0033 0.0089 0.0505
Entamoeba histolytica hypothetical protein 0.0037 0.0107 0.3245
Entamoeba histolytica hypothetical protein 0.0037 0.0107 0.3245
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0331 0.1876
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0099 0.0281
Loa Loa (eye worm) hypothetical protein 0.0035 0.0099 0.0743
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0357 0.202
Schistosoma mansoni cpg binding protein 0.0033 0.0089 0.0505
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0019 0.003 0.0173
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.009 0.0508
Brugia malayi Pre-SET motif family protein 0.0033 0.009 0.1021
Loa Loa (eye worm) norepinephrine transporter 0.0019 0.003 0.023
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.003 0.0173
Plasmodium vivax importin-beta 2, putative 0.0032 0.0083 0.0128
Brugia malayi SET domain containing protein 0.0013 0.0008 0.0087
Onchocerca volvulus 0.0035 0.0099 0.098
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.023
Toxoplasma gondii aldehyde dehydrogenase 0.0072 0.0247 0.0379
Schistosoma mansoni hypothetical protein 0.0336 0.1325 0.7506
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0055 0.0084
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0072 0.0247 0.1401
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0059 0.0587
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0331 0.2495
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0019 0.003 0.003
Toxoplasma gondii hypothetical protein 0.1616 0.6536 1
Brugia malayi hypothetical protein 0.0164 0.0624 0.7097
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.007 0.007
Schistosoma mansoni ran 0.0023 0.0049 0.028
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0099 0.0558
Leishmania major hypothetical protein, conserved 0.0025 0.0055 0.0101
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0099 0.0151
Echinococcus granulosus sodium and chloride dependent glycine 0.0096 0.0344 0.1947
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0082 0.0617
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0019 0.003 0.0347
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0108 0.012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0229 0.1299
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0247 0.1401
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0007 0.0041
Plasmodium falciparum phd finger protein, putative 0.0028 0.007 0.0108
Plasmodium falciparum transporter, putative 0.0019 0.003 0.0047
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0007 0.0007
Mycobacterium ulcerans beta-lactamase 0.0035 0.0099 0.0105
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0055 0.0084
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0055 0.0084
Trypanosoma brucei Peptide deformylase 2 0.0617 0.2466 1
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0159 0.0159
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.003 0.0046
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0159 0.053
Entamoeba histolytica hypothetical protein 0.0037 0.0107 0.3245
Schistosoma mansoni sodium-dependent amino acid transporter 0.0019 0.003 0.0173
Schistosoma mansoni kinase 0.0047 0.0147 0.0833
Brugia malayi chromobox protein homolog 3 0.0038 0.011 0.1247
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0126 0.0393
Loa Loa (eye worm) hypothetical protein 0.0033 0.009 0.0676
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0107 0.0609
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0082 0.0465
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0049 0.0049
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0019 0.003 0.003
Brugia malayi Importin beta-1 subunit 0.0032 0.0083 0.0948
Schistosoma mansoni hypothetical protein 0.0037 0.0107 0.0609
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.003 0.0173
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0357 0.0357
Onchocerca volvulus Alhambra homolog 0.0028 0.007 0.07
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0193 0.1458
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.007 0.0108
Echinococcus granulosus peregrin 0.0028 0.007 0.0399
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0357 0.202
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0049 0.0372
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0019 0.003 0.003
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0102 0.0577
Brugia malayi Inositol-1 0.0042 0.0126 0.1433
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0099 0.0105
Onchocerca volvulus 0.0035 0.0099 0.098
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.023
Loa Loa (eye worm) beta-lactamase 0.0035 0.0099 0.0743
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0331 0.1236
Echinococcus multilocularis cpg binding protein 0.0033 0.0089 0.0089
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.0357 0.4057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0357 0.0357
Loa Loa (eye worm) hypothetical protein 0.0035 0.0099 0.0743
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0126 0.1252
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0102 0.0577
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0116 0.0655
Plasmodium falciparum amino acid transporter, putative 0.0019 0.003 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0099 0.0281
Loa Loa (eye worm) serotonin transporter b 0.0019 0.003 0.023
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0099 0.098
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0029 0.0286
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0159 0.053
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0121 0.1207
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0331 0.1236
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.009 0.0508
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0029 0.0286
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.007 0.053
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.003 0.0343
Treponema pallidum polypeptide deformylase (def) 0.1616 0.6536 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.003 0.0912
Brugia malayi hypothetical protein 0.0037 0.0107 0.1223
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0029 0.0286
Mycobacterium ulcerans peptide deformylase 0.1616 0.6536 1
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0159 0.0902
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.009 0.009
Schistosoma mansoni sodium/chloride dependent transporter 0.0096 0.0347 0.1965
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0126 0.0193
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0055 0.0101
Brugia malayi PHD-finger family protein 0.0028 0.007 0.0801
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0019 0.003 0.0173
Loa Loa (eye worm) solute carrier family 6 member 4 0.0019 0.003 0.023
Echinococcus multilocularis sodium and chloride dependent glycine 0.0096 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0096 0.0344 0.259
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0049 0.0076
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0083 0.0218
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.009 0.0137
Brugia malayi RNA, U transporter 1 0.009 0.032 0.3646
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.0357 0.2687
Schistosoma mansoni hypothetical protein 0.0028 0.007 0.0399
Onchocerca volvulus 0.003 0.0076 0.0757
Loa Loa (eye worm) hypothetical protein 0.0164 0.0624 0.4699
Onchocerca volvulus 0.0019 0.003 0.0303
Trypanosoma cruzi Peptide deformylase 2, putative 0.0617 0.2466 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0019 0.003 0.0173
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0072 0.0247 0.0247
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0049 0.028
Loa Loa (eye worm) hypothetical protein 0.0035 0.0099 0.0743
Loa Loa (eye worm) hypothetical protein 0.0035 0.0099 0.0743
Schistosoma mansoni chromobox protein 0.0068 0.0231 0.1309
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0126 0.0393
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0142 0.1412
Echinococcus granulosus chromobox protein 1 0.0068 0.0231 0.1309
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.0347
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0231 0.2296
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0083 0.0083
Onchocerca volvulus 0.0031 0.0082 0.0814
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0036 0.0413
Echinococcus multilocularis chromobox protein 1 0.0068 0.0231 0.0231
Schistosoma mansoni inositol monophosphatase 0.0042 0.0126 0.0714
Loa Loa (eye worm) inositol-1 0.0042 0.0126 0.0949
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0574
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0049 0.0639
Leishmania major importin beta-1 subunit, putative 0.0026 0.0059 0.0118
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0099 0.098
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0126 0.0147
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0201 0.0307
Mycobacterium ulcerans hypothetical protein 0.0035 0.0099 0.0105
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0096 0.0344 0.3912
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0159 0.0244
Onchocerca volvulus 0.0164 0.0624 0.6199
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0072 0.0247 0.0334
Loa Loa (eye worm) hypothetical protein 0.0038 0.011 0.0826
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0019 0.003 0.0173
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0331 0.3291
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.009 0.0508
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0049 0.0079
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0357 0.202
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0099 0.098
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.007 0.0108
Schistosoma mansoni importin beta-1 0.0032 0.0083 0.0472
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0331 0.3291
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.011 0.109
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0099 0.0743
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0059 0.0587
Echinococcus multilocularis peregrin 0.0028 0.007 0.007
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0059 0.0118
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0126 0.0393
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.003 0.0173
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0007 0.0055
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0121 0.1207
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0013 0.0133
Toxoplasma gondii ABC1 family protein 0.0035 0.0099 0.0151
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0099 0.0105
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0159 0.12
Loa Loa (eye worm) hypothetical protein 0.0035 0.0099 0.0743
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0333 0.1888
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0015 0.0154
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0159 0.1582
Schistosoma mansoni cpg binding protein 0.0031 0.0082 0.0464
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0108 0.0015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0029 0.0286
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0095 0.0095
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0331 0.3291
Echinococcus granulosus geminin 0.0336 0.1325 0.7506
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0049 0.0076
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0099 0.0105
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.003 0.03
Trypanosoma brucei polo-like protein kinase 0.0092 0.0331 0.1236
Schistosoma mansoni inositol monophosphatase 0.0042 0.0126 0.0714
Schistosoma mansoni hypothetical protein 0.0445 0.1765 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0159 0.053
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.023
Entamoeba histolytica hypothetical protein 0.0037 0.0107 0.3245
Loa Loa (eye worm) hypothetical protein 0.0096 0.0344 0.259
Onchocerca volvulus 0.0044 0.0135 0.1341
Echinococcus multilocularis serotonin transporter 0.0019 0.003 0.003
Leishmania major hypothetical protein, conserved 0.0035 0.0099 0.0281
Entamoeba histolytica Ran family GTPase 0.0023 0.0049 0.1492
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.003 0.0173
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0126 0.1252
Mycobacterium tuberculosis Conserved protein 0.0035 0.0099 0.0105
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0029 0.0286
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.003 0.03

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2816 nM Inhibition of human Glycine Transporter type-2 ChEMBL. 11495577
IC50 (binding) = 2816 nM Inhibition of human Glycine Transporter type-2 ChEMBL. 11495577

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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