TDR Targets

Basic information

Technical information

TDR Targets ID: 1463179
Name: N-[(6-methoxy-2-oxo-1H-quinolin-3-yl)methyl]- N-(thiophen-2-ylmethyl)cyclohexanecarboxamide
MW: 410.529 | Formula: C23H26N2O3S
H donors: 1 H acceptors: 2 LogP: 3.9 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(c1)cc(c(=O)[nH]2)CN(C(=O)C1CCCCC1)Cc1cccs1
InChi: 1S/C23H26N2O3S/c1-28-19-9-10-21-17(13-19)12-18(22(26)24-21)14-25(15-20-8-5-11-29-20)23(27)16-6-3-2-4-7-16/h5,8-13,16H,2-4,6-7,14-15H2,1H3,(H,24,26)
InChiKey: XJXAMVMWUINRMH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(6-methoxy-2-oxo-1H-quinolin-3-yl)methyl]-N-(2-thienylmethyl)cyclohexanecarboxamide
N-[(2-keto-6-methoxy-1H-quinolin-3-yl)methyl]-N-(2-thienylmethyl)cyclohexanecarboxamide
ASN 05107637
ZINC04231090

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.0221	0.0633	1
Onchocerca volvulus		0.0071	0.0163	0.1763
Brugia malayi	beta-lactamase family protein	0.0071	0.0163	0.0163
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0071	0.0163	0.0163
Schistosoma mansoni	hypothetical protein	0.0054	0.011	0.011
Loa Loa (eye worm)	hhat protein	0.0064	0.0142	0.0142
Toxoplasma gondii	methionyl-tRNA synthetase	0.0055	0.0114	0.1004
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0025	0.0217
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.3218	1	1
Loa Loa (eye worm)	beta-lactamase	0.0071	0.0163	0.0163
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0243	0.07	0.07
Trypanosoma brucei	glycerol uptake protein, putative	0.0064	0.0142	0.2024
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.0224	0.0224
Trichomonas vaginalis	conserved hypothetical protein	0.0221	0.0633	1
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0381	0.1131	0.1131
Loa Loa (eye worm)	MBOAT family protein	0.0064	0.0142	0.0142
Leishmania major	leucyl-tRNA synthetase, putative	0.0021	0.0007	0.0106
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0071	0.0163	0.0163
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.0163	0.2574
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0163	0.0163
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0064	0.0142	1
Entamoeba histolytica	methionyl-tRNA synthetase, putative	0.0021	0.0007	0.0522
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.009	0.0224	0.0224
Treponema pallidum	leucyl-tRNA synthetase	0.0021	0.0007	0.0522
Brugia malayi	MBOAT family protein	0.0064	0.0142	0.0142
Schistosoma mansoni	hypothetical protein	0.0033	0.0046	0.0046
Trypanosoma brucei	glycerol uptake protein, putative	0.0064	0.0142	0.2024
Echinococcus multilocularis	methionine tRNA synthetase	0.0055	0.0114	0.0114
Mycobacterium ulcerans	beta-lactamase	0.0071	0.0163	1
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0381	0.1131	1
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0064	0.0142	0.0142
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0025	0.035
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0381	0.1131	0.1131
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0163	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0163	0.0163
Echinococcus granulosus	alpha 13 mannosyl glycoprotein	0.0217	0.0621	0.0621
Schistosoma mansoni	methionine-tRNA synthetase	0.0021	0.0007	0.0007
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0025	0.035
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0071	0.0163	0.1203
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0142	0.0142
Trypanosoma brucei	diacylglycerol acyltransferase, putative	0.0054	0.011	0.1569
Loa Loa (eye worm)	hypothetical protein	0.0317	0.0931	0.0931
Brugia malayi	MBOAT family protein	0.0064	0.0142	0.0142
Brugia malayi	methionyl-tRNA synthetase	0.0021	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0026	0.0025	0.0025
Brugia malayi	beta-lactamase family protein	0.0071	0.0163	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0007	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0135	0.0364	0.5739
Brugia malayi	methionyl-tRNA synthetase	0.0055	0.0114	0.0114
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0064	0.0142	0.0142
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0064	0.0142	0.0142
Entamoeba histolytica	vacuolar protein sorting 26	0.0064	0.0142	1
Trypanosoma brucei	methionyl-tRNA synthetase, putative	0.0055	0.0114	0.1622
Brugia malayi	Zinc finger, C2H2 type family protein	0.0306	0.0898	0.0898
Schistosoma mansoni	methionine-tRNA synthetase	0.0055	0.0114	0.0114
Brugia malayi	Glycosylation related protein 12, isoform	0.0074	0.0172	0.0172
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.0224	0.0224
Leishmania major	glycerol uptake protein, putative	0.0064	0.0142	0.2024
Echinococcus granulosus	methionyl tRNA synthetase cytoplasmic	0.0021	0.0007	0.0007
Brugia malayi	Hhat protein	0.0064	0.0142	0.0142
Trichomonas vaginalis	esterase, putative	0.0071	0.0163	0.2574
Mycobacterium ulcerans	esterase/lipase LipP	0.0071	0.0163	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0071	0.0163	0.1203
Echinococcus granulosus	sterol O acyltransferase 1	0.0064	0.0142	0.0142
Plasmodium falciparum	methionine--tRNA ligase, putative	0.0021	0.0007	0.0065
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0054	0.011	0.1569
Trichomonas vaginalis	methionine-tRNA synthetase, putative	0.0055	0.0114	0.1793
Trichomonas vaginalis	porcupine, putative	0.0064	0.0142	0.2238
Entamoeba histolytica	hypothetical protein	0.0064	0.0142	1
Leishmania major	glycerol uptake protein, putative	0.0064	0.0142	0.2024
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0142	0.0142
Mycobacterium tuberculosis	Conserved protein	0.0071	0.0163	0.1203
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.0163	0.2574
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0452	0.1355	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0142	0.0142
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0054	0.011	0.1569
Plasmodium falciparum	methionine--tRNA ligase	0.0055	0.0114	0.1004
Leishmania major	diacylglycerol acyltransferase, putative	0.0054	0.011	0.1569
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0046	0.0046
Plasmodium vivax	hypothetical protein, conserved	0.0071	0.0163	0.1441
Leishmania major	hypothetical protein, conserved	0.0026	0.0025	0.035
Trypanosoma brucei	hypothetical protein, conserved	0.0071	0.0163	0.2327
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0064	0.0142	0.0142
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0064	0.0142	0.0142
Onchocerca volvulus		0.0238	0.0686	0.9781
Trichomonas vaginalis	conserved hypothetical protein	0.0221	0.0633	1
Mycobacterium ulcerans	hypothetical protein	0.0054	0.011	0.6741
Schistosoma mansoni	beta-12-n-acetylglucosaminyltransferase II	0.3218	1	1
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0064	0.0142	0.0142
Trichomonas vaginalis	penicillin-binding protein, putative	0.0071	0.0163	0.2574
Brugia malayi	diacylglycerol acyltransferase	0.0381	0.1131	0.1131
Echinococcus multilocularis	leucyl tRNA synthetase	0.0021	0.0007	0.0007
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0224	0.0224
Trichomonas vaginalis	conserved hypothetical protein	0.0221	0.0633	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0025	0.0025
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0094	0.0094
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0053	0.0053
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0071	0.0163	0.0163
Mycobacterium leprae	conserved hypothetical protein	0.0071	0.0163	1
Mycobacterium ulcerans	lipase LipD	0.0071	0.0163	1
Trichomonas vaginalis	conserved hypothetical protein	0.0221	0.0633	1
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0381	0.1131	1
Echinococcus multilocularis	sterol O acyltransferase 1	0.0064	0.0142	0.0142
Toxoplasma gondii	hypothetical protein	0.0086	0.0212	0.1871
Loa Loa (eye worm)	hypothetical protein	0.0217	0.0621	0.0621
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0163	0.0163
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0064	0.0142	0.0142
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.0163	0.2327
Leishmania major	glycerol uptake protein, putative	0.0064	0.0142	0.2024
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0064	0.0142	0.0142
Trypanosoma cruzi	glycerol uptake protein, putative	0.0064	0.0142	0.2024
Brugia malayi	Pax transcription factor protein 2	0.0238	0.0686	0.0686
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0071	0.0163	1
Toxoplasma gondii	hypothetical protein	0.0064	0.0142	0.1253
Trypanosoma cruzi	GUP1, putative	0.0064	0.0142	0.2024
Treponema pallidum	alginate O-acetylation protein (algI)	0.0064	0.0142	1
Trypanosoma cruzi	glycerol uptake protein, putative	0.0064	0.0142	0.2024
Brugia malayi	MBOAT family protein	0.0064	0.0142	0.0142
Toxoplasma gondii	mono- or diacylglycerol acyltransferase	0.0054	0.011	0.0971
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.0163	0.2327
Leishmania major	hypothetical protein, conserved	0.0071	0.0163	0.2327
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0054	0.011	0.1569
Echinococcus granulosus	alpha 16 mannosyl glycoprotein	0.3218	1	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0025	0.0217
Entamoeba histolytica	hypothetical protein	0.0036	0.0053	0.3746
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0224	0.0224
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0381	0.1131	0.1131
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0025	0.035
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0163	0.0163
Trypanosoma cruzi	glycerol uptake protein, putative	0.0064	0.0142	0.2024
Echinococcus granulosus	methionine tRNA synthetase	0.0055	0.0114	0.0114
Schistosoma mansoni	diacylglycerol O-acyltransferase	0.0054	0.011	0.011
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0381	0.1131	1
Entamoeba histolytica	hypothetical protein, conserved	0.0064	0.0142	1
Loa Loa (eye worm)	hhat protein	0.0064	0.0142	0.0142
Brugia malayi	MBOAT family protein	0.0064	0.0142	0.0142
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.009	0.0224	0.0224
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0064	0.0142	0.0142
Schistosoma mansoni	hypothetical protein	0.0036	0.0053	0.0053
Echinococcus multilocularis	alpha 1,6 mannosyl glycoprotein	0.3218	1	1
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0064	0.0142	0.0142
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0054	0.011	0.1569
Chlamydia trachomatis	methionine--tRNA ligase	0.0021	0.0007	0.5
Toxoplasma gondii	Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	0.0074	0.0172	0.1524
Schistosoma mansoni	hypothetical protein	0.0064	0.0142	0.0142
Loa Loa (eye worm)	MBOAT family protein	0.0064	0.0142	0.0142
Leishmania major	glycerol uptake protein, putative	0.0064	0.0142	0.2024
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0025	0.0217
Toxoplasma gondii	tRNA ligases class I (M) protein	0.0021	0.0007	0.0065
Mycobacterium tuberculosis	Probable lipase LipE	0.0071	0.0163	0.1203
Trichomonas vaginalis	transmembrane protein nessy, putative	0.0064	0.0142	0.2238
Leishmania major	diacylglycerol acyltransferase, putative	0.0243	0.07	1
Trichomonas vaginalis	conserved hypothetical protein	0.0221	0.0633	1
Loa Loa (eye worm)	MBOAT family protein	0.0064	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0094	0.0094
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0064	0.0142	0.0142
Toxoplasma gondii	diacylglycerol acyltransferase	0.0054	0.011	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0142	0.0142
Brugia malayi	diacylglycerol acyltransferase family protein	0.0243	0.07	0.07
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0071	0.0163	0.1203
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0071	0.0163	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0007	0.0007
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0064	0.0142	1
Schistosoma mansoni	diacylglycerol O-acyltransferase	0.0054	0.011	0.011
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0142	0.2238
Toxoplasma gondii	dgat2l1-prov protein	0.0243	0.07	0.6192
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0094	0.0094
Brugia malayi	hypothetical protein	0.0036	0.0053	0.0053
Loa Loa (eye worm)	zinc finger protein	0.0306	0.0898	0.0898
Brugia malayi	beta-lactamase	0.0071	0.0163	0.0163
Brugia malayi	protein ZK524.3	0.0021	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0172	0.0172
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0142	0.2238
Leishmania major	glycerol uptake protein, putative	0.0064	0.0142	0.2024
Trichomonas vaginalis	conserved hypothetical protein	0.0221	0.0633	1
Trypanosoma brucei	diacylglycerol acyltransferase, putative	0.0243	0.07	1
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0381	0.1131	1
Echinococcus multilocularis	alpha 1,3 mannosyl glycoprotein	0.0217	0.0621	0.0621
Onchocerca volvulus		0.0064	0.0142	0.1437
Leishmania major	methionyl-tRNA synthetase, putative	0.0055	0.0114	0.1622
Loa Loa (eye worm)	tyrosyl-tRNA synthetase	0.0034	0.0048	0.0048
Onchocerca volvulus		0.0071	0.0163	0.1763
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0064	0.0142	0.0142
Echinococcus granulosus	zinc finger transcription factor gli2	0.0306	0.0898	0.0898
Chlamydia trachomatis	leucine--tRNA ligase	0.0021	0.0007	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0142	0.2238
Mycobacterium ulcerans	leucyl-tRNA synthetase	0.0021	0.0007	0.0454
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0094	0.0094
Giardia lamblia	Methionyl-tRNA synthetase	0.0055	0.0114	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0071	0.0163	0.2574
Loa Loa (eye worm)	methionyl-tRNA synthetase	0.0055	0.0114	0.0114
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0064	0.0142	0.0142
Plasmodium vivax	hypothetical protein, conserved	0.0021	0.0007	0.0065
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0243	0.07	1
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0064	0.0142	0.0142
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0064	0.0142	0.0142
Onchocerca volvulus		0.0071	0.0163	0.1763
Leishmania major	hypothetical protein, conserved	0.0064	0.0142	0.2024
Plasmodium vivax	methionine--tRNA ligase, putative	0.0055	0.0114	0.1004
Echinococcus multilocularis	methionyl tRNA synthetase, cytoplasmic	0.0021	0.0007	0.0007
Entamoeba histolytica	hypothetical protein	0.0036	0.0053	0.3746
Treponema pallidum	methionyl-tRNA synthetase	0.0021	0.0007	0.0522
Entamoeba histolytica	hypothetical protein	0.0036	0.0053	0.3746
Plasmodium vivax	methionine--tRNA ligase, putative	0.0021	0.0007	0.0065
Mycobacterium ulcerans	hypothetical protein	0.0071	0.0163	1
Mycobacterium tuberculosis	Conserved protein	0.0071	0.0163	0.1203
Schistosoma mansoni	zinc finger protein	0.0064	0.0142	0.0142
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0243	0.07	0.07
Schistosoma mansoni	leucyl-tRNA synthetase	0.0021	0.0007	0.0007
Mycobacterium tuberculosis	Probable esterase LipL	0.0071	0.0163	0.1203
Mycobacterium tuberculosis	Conserved protein	0.0071	0.0163	0.1203
Giardia lamblia	Leucyl-tRNA synthetase	0.0021	0.0007	0.0651
Onchocerca volvulus		0.0243	0.07	1
Mycobacterium tuberculosis	Probable hydrolase	0.0071	0.0163	0.1203
Brugia malayi	GNT-I family protein	0.0217	0.0621	0.0621
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0064	0.0142	0.0142
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0064	0.0142	0.0142
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.0163	0.2574
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0071	0.0163	0.0163
Schistosoma mansoni	sterol O-acyltransferase 1	0.0064	0.0142	0.0142
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.0224	0.0224
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0381	0.1131	0.1131
Echinococcus multilocularis	zinc finger transcription factor gli2	0.0306	0.0898	0.0898
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0163	0.0163
Schistosoma mansoni	alpha-13-mannosyl-glycoprotein beta-1 2-n-acetylglucosaminyltransferase	0.0217	0.0621	0.0621
Leishmania major	diacylglycerol acyltransferase, putative	0.0054	0.011	0.1569
Mycobacterium leprae	Probable lipase LipE	0.0071	0.0163	1
Mycobacterium ulcerans	methionyl-tRNA synthetase	0.0055	0.0114	0.6967
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0064	0.0142	0.0142
Loa Loa (eye worm)	pax transcription factor protein 2	0.0238	0.0686	0.0686
Entamoeba histolytica	hypothetical protein	0.0036	0.0053	0.3746
Brugia malayi	MBOAT family protein	0.0064	0.0142	0.0142
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0064	0.0142	0.0142
Toxoplasma gondii	ABC1 family protein	0.0071	0.0163	0.1441
Trypanosoma cruzi	diacylglycerol acyltransferase, putative	0.0243	0.07	1
Trichomonas vaginalis	conserved hypothetical protein	0.0221	0.0633	1
Trypanosoma cruzi	GUP1, putative	0.0064	0.0142	0.2024
Echinococcus granulosus	beta LACTamase domain containing family member	0.0071	0.0163	0.0163
Wolbachia endosymbiont of Brugia malayi	leucyl-tRNA synthetase	0.0021	0.0007	0.0651
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0025	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0217	0.0621	0.0621
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0053	0.0053
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0064	0.0142	0.0142
Trypanosoma cruzi	methionyl-tRNA synthetase, putative	0.0055	0.0114	0.1622
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0053	0.0053
Mycobacterium tuberculosis	Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase)	0.0055	0.0114	0.0838
Leishmania major	hypothetical protein, unknown function,protein, unknown function	0.0054	0.011	0.1569
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0064	0.0142	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0071	0.0163	0.1203
Wolbachia endosymbiont of Brugia malayi	methionyl-tRNA synthetase	0.0055	0.0114	1

Activities

Activity type	Activity value	Assay description	Source	Reference
CC50 (ADMET)	> 48 uM	Cytotoxicity against human MT2 cells after 4 days by XTT assay	ChEMBL.	21168336

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1645074

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1463179