TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 304.386 | Formula: C20H20N2O
H donors: 1 H acceptors: 1 LogP: 3.98 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1ccc(cc1)c1cccc(c1)O[C@@H]1C[C@H]2CC[C@@H](C1)N2
InChi: 1S/C20H20N2O/c21-13-14-4-6-15(7-5-14)16-2-1-3-19(10-16)23-20-11-17-8-9-18(12-20)22-17/h1-7,10,17-18,20,22H,8-9,11-12H2/t17-,18+,20-
InChiKey: RGCRPWWXLBCYBL-OPVJXMOQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 3	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 2	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	norepinephrine/norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	serotonin transporter b	Get druggable targets OG5_128364	All targets in OG5_128364
Onchocerca volvulus		Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	solute carrier family 6 member 4	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus granulosus	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Treponema pallidum	sodium- and chloride- dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus multilocularis	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent noradrenaline transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Brugia malayi	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 4	630 aa	574 aa	31.5 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 2	617 aa	638 aa	32.5 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 3	620 aa	579 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.005	0.0912	0.1247
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0171	0.0114
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Echinococcus multilocularis	acetylcholinesterase	0.0071	0.1387	0.1975
Echinococcus granulosus	solute carrier family 22	0.0015	0.0171	0.0114
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0039	0.0671	0.9902
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0418	0.0491
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0171	0.0114
Trypanosoma brucei	unspecified product	0.001	0.0054	0.0732
Brugia malayi	Ubiquitin conjugating enzyme protein 13	0.0039	0.0677	0.0953
Loa Loa (eye worm)	hypothetical protein	0.0292	0.6185	0.9312
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0042	0.0741	0.3023
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.005	0.0912	0.1247
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0567	0.072
Giardia lamblia	Prolyl-tRNA synthetase	0.0033	0.0552	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0039	0.0677	0.0888
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.0577	0.7781
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0171	0.0114
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0912	0.1277
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.035	0.1191
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0741	1
Plasmodium vivax	proline--tRNA ligase, putative	0.0039	0.0671	0.051
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0552	0.0698
Brugia malayi	polk-prov protein	0.0032	0.052	0.0697
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0912	0.1277
Echinococcus multilocularis	serotonin transporter	0.0292	0.6185	0.9312
Plasmodium vivax	amine transporter, putative	0.005	0.0912	0.0754
Onchocerca volvulus		0.0015	0.0171	0.0122
Toxoplasma gondii	sugar transporter ST1	0.0015	0.0171	0.0141
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0034	0.0568	0.0404
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0015	0.0171	0.3659
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0034	0.0568	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1387	0.1975
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0171	0.0114
Onchocerca volvulus		0.0015	0.0171	0.0122
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.011	0.2229	0.3262
Echinococcus granulosus	snurportin 1	0.0313	0.6635	1
Onchocerca volvulus		0.0292	0.6185	1
Plasmodium falciparum	hexose transporter	0.011	0.2229	0.2094
Brugia malayi	Sugar transporter family protein	0.0015	0.0171	0.0122
Trypanosoma brucei	DNA polymerase eta, putative	0.0015	0.0154	0.2072
Echinococcus granulosus	lamin dm0	0.0027	0.043	0.051
Mycobacterium ulcerans	sugar transporter	0.0015	0.0171	0.127
Loa Loa (eye worm)	hypothetical protein	0.0013	0.011	0.0022
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0021	0.0288	0.9434
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0034	0.0567	0.072
Schistosoma mansoni	glucose transport protein	0.011	0.2229	0.3262
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.043	0.0547
Echinococcus multilocularis	sodium and chloride dependent glycine	0.005	0.0912	0.1247
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.0303	0.0343
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.011	0.2229	0.3262
Loa Loa (eye worm)	serotonin transporter b	0.0292	0.6185	0.9312
Loa Loa (eye worm)	hypothetical protein	0.0292	0.6185	0.9312
Loa Loa (eye worm)	hypothetical protein	0.0027	0.043	0.051
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.02	0.2699
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0034	0.0567	0.072
Brugia malayi	major facilitator superfamily protein	0.0015	0.0171	0.0122
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0033	0.0552	0.0698
Echinococcus multilocularis	lysyl tRNA synthetase	0.0025	0.0368	0.0416
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0039	0.0677	0.8903
Loa Loa (eye worm)	sugar transporter	0.011	0.2229	0.3262
Onchocerca volvulus		0.0015	0.0171	0.0122
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0471	0.6353
Echinococcus granulosus	dna polymerase eta	0.0015	0.0154	0.0088
Schistosoma mansoni	sodium/chloride dependent transporter	0.0292	0.6185	0.9312
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.005	0.0912	0.1247
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0171	0.0114
Echinococcus multilocularis	acetylcholinesterase	0.0071	0.1387	0.1975
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0171	0.0114
Plasmodium vivax	hypothetical protein, conserved	0.005	0.0912	0.0754
Onchocerca volvulus		0.0015	0.0171	0.0122
Loa Loa (eye worm)	pax transcription factor protein 2	0.0244	0.5151	0.7731
Onchocerca volvulus		0.0015	0.0171	0.0122
Toxoplasma gondii	transporter, major facilitator family protein	0.0015	0.0171	0.0141
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.005	0.0912	0.1247
Leishmania major	hypothetical protein, conserved	0.0015	0.0171	0.0325
Plasmodium falciparum	amino acid transporter, putative	0.005	0.0912	0.0754
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Entamoeba histolytica	hypothetical protein	0.0025	0.0368	0.4108
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.011	0.2229	0.3262
Onchocerca volvulus		0.0015	0.0171	0.0122
Trypanosoma cruzi	hexose transporter	0.0034	0.0577	0.7201
Trypanosoma brucei	DNA polymerase kappa, putative	0.0032	0.052	0.7024
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0567	0.072
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0039	0.0671	0.8815
Onchocerca volvulus	Putative transporter	0.0015	0.0171	0.0122
Brugia malayi	hypothetical protein	0.0015	0.0171	0.0122
Echinococcus multilocularis	carboxylesterase 5A	0.0071	0.1387	0.1975
Toxoplasma gondii	facilitative glucose transporter GT1	0.011	0.2229	0.3297
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0171	0.0122
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.0741	1
Echinococcus multilocularis	sodium and chloride dependent glycine	0.005	0.0912	0.1247
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.005	0.0912	0.134
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0171	0.0114
Trichomonas vaginalis	ran, putative	0.0022	0.0303	0.0968
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0912	0.134
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Brugia malayi	hypothetical protein	0.005	0.0912	0.134
Loa Loa (eye worm)	hypothetical protein	0.005	0.0912	0.1247
Onchocerca volvulus		0.0015	0.0171	0.0122
Loa Loa (eye worm)	hypothetical protein	0.005	0.0912	0.1247
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0171	0.0114
Plasmodium falciparum	protein kinase 7	0.0311	0.6601	0.6542
Plasmodium vivax	hexose transporter	0.011	0.2229	0.2094
Echinococcus multilocularis	lamin dm0	0.0027	0.043	0.051
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0471	0.0601
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.0577	0.2252
Toxoplasma gondii	sugar transporter ST3	0.0015	0.0171	0.0141
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0025	0.0368	0.3046
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.0741	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0912	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0171	0.0114
Brugia malayi	Importin beta-1 subunit	0.0029	0.0471	0.0615
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0368	0.4297
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Trypanosoma cruzi	sugar transporter, putative	0.0015	0.0171	0.0289
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0034	0.0567	0.072
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0303	0.0316
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0303	0.2538
Onchocerca volvulus		0.0244	0.5151	0.8302
Toxoplasma gondii	lysine-tRNA ligase	0.0025	0.0368	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0171	0.0114
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0292	0.6185	0.9312
Plasmodium vivax	ubiquitin-conjugating enzyme E2 N, putative	0.0039	0.0677	0.0515
Echinococcus granulosus	General substrate transporter	0.0095	0.1892	0.2747
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0741	1
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.0299	0.2787
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0171	0.0114
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0178	0.3704	0.3595
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.011	0.2229	0.3262
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0303	0.0316
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0741	1
Echinococcus granulosus	acetylcholinesterase	0.0071	0.1387	0.1975
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0567	0.072
Loa Loa (eye worm)	carboxylesterase	0.0071	0.1387	0.1975
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0034	0.0568	0.075
Brugia malayi	ImpB/MucB/SamB family protein	0.0015	0.0154	0.0094
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0039	0.0671	0.9902
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0039	0.0677	0.8903
Onchocerca volvulus		0.005	0.0912	0.134
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0033	0.0552	0.2139
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0577	0.7781
Trypanosoma brucei	glucose transporter 1E	0.0034	0.0577	0.7781
Loa Loa (eye worm)	hypothetical protein	0.0013	0.011	0.0022
Onchocerca volvulus		0.0015	0.0171	0.0122
Echinococcus granulosus	intermediate filament protein	0.0027	0.043	0.051
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0368	0.4297
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0567	0.072
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.043	0.051
Echinococcus multilocularis	dna polymerase kappa	0.0042	0.0741	0.0986
Brugia malayi	intermediate filament protein	0.0027	0.043	0.0547
Echinococcus granulosus	acetylcholinesterase	0.0071	0.1387	0.1975
Schistosoma mansoni	lamin	0.0027	0.043	0.051
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0071	0.1387	0.1975
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0034	0.0567	0.072
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Trypanosoma brucei	DNA polymerase kappa, putative	0.0032	0.052	0.7024
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0303	0.0339
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.0577	0.7201
Giardia lamblia	Lysyl-tRNA synthetase	0.0025	0.0368	0.5182
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0014	0.0129	0.005
Chlamydia trachomatis	lysine--tRNA ligase	0.0025	0.0368	0.3407
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0577	0.7781
Trichomonas vaginalis	conserved hypothetical protein	0.011	0.2229	1
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.043	0.051
Mycobacterium ulcerans	DNA polymerase IV	0.0042	0.0741	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.0303	0.4084
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0171	0.0348
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.035	0.1191
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.0741	1
Onchocerca volvulus		0.0015	0.0171	0.0122
Schistosoma mansoni	lamin	0.0027	0.043	0.051
Mycobacterium ulcerans	DNA polymerase IV	0.0042	0.0741	1
Leishmania major	protein kinase, putative	0.0034	0.0567	0.7909
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0912	0.1277
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1387	0.1975
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0741	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.011	0.2229	0.3262
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0034	0.0568	0.075
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.0567	0.072
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0171	0.0114
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0471	0.0305
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0015	0.0154	0.0088
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0025	0.0368	0.1276
Loa Loa (eye worm)	hypothetical protein	0.0032	0.052	0.0649
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0912	0.1247
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0912	0.1247
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0292	0.6185	0.9312
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0033	0.0552	0.0749
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.0577	0.7781
Entamoeba histolytica	Ran family GTPase	0.0022	0.0303	0.285
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0171	0.0114
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0912	0.134
Schistosoma mansoni	ran	0.0022	0.0303	0.0316
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0033	0.0552	0.0749
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0039	0.0671	0.8815
Trypanosoma brucei	ubiquitin-protein ligase, putative	0.0039	0.0677	0.913
Brugia malayi	Cam kinase protein 1	0.0034	0.0567	0.0773
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0577	0.2252
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0015	0.0154	0.0088
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0171	0.0122
Leishmania major	glucose transporter, lmgt1	0.0034	0.0577	0.8089
Schistosoma mansoni	protein kinase	0.0034	0.0567	0.072
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0171	0.0114
Schistosoma mansoni	intermediate filament proteins	0.0027	0.043	0.051
Echinococcus granulosus	solute carrier family 22	0.0015	0.0171	0.0114
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.005	0.0912	1
Trypanosoma cruzi	hexose transporter, putative	0.0019	0.024	0.1468
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0015	0.0171	0.3659
Brugia malayi	ubiquitin conjugating enzyme protein 13	0.0039	0.0677	0.0953
Echinococcus multilocularis	musashi	0.0027	0.043	0.051
Schistosoma mansoni	sodium/chloride dependent transporter	0.0052	0.0958	0.1317
Trypanosoma cruzi	hexose transporter, putative	0.0015	0.0171	0.0289
Schistosoma mansoni	hypothetical protein	0.011	0.2229	0.3262
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0577	0.7781
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0419	0.0493
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0022	0.0303	0.0134
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0171	0.0122
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0039	0.0671	0.9061
Leishmania major	DNA polymerase kappa, putative	0.0021	0.0299	0.2787
Loa Loa (eye worm)	hypothetical protein	0.005	0.0912	0.1247
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0033	0.0552	0.0698
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0471	0.0573
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0171	0.0114
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0171	0.127
Schistosoma mansoni	sugar transporter	0.0015	0.0171	0.0114
Trichomonas vaginalis	DNA polymerase eta, putative	0.0042	0.0741	0.3023
Trypanosoma brucei	DNA polymerase IV, putative	0.0042	0.0741	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0171	0.0114
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0153	0.0093
Schistosoma mansoni	sugar transporter	0.0015	0.0171	0.0114
Echinococcus granulosus	sodium and chloride dependent glycine	0.005	0.0912	0.1247
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0034	0.0567	0.072
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0171	0.0348
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.035	0.1191
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.005	0.0912	0.1247
Loa Loa (eye worm)	hypothetical protein	0.005	0.0912	0.1247
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0039	0.0677	0.0888
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0171	0.0348
Giardia lamblia	DINP protein human, muc B family	0.0021	0.0299	0.3372
Onchocerca volvulus		0.0015	0.0171	0.0122
Brugia malayi	lysyl-tRNA synthetase	0.0025	0.0368	0.0447
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0577	0.2252
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0171	0.0348
Toxoplasma gondii	hypothetical protein	0.005	0.0912	0.1277
Brugia malayi	hypothetical protein	0.0015	0.0171	0.0122
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0015	0.0154	0.0088
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Schistosoma mansoni	glucose transport protein	0.011	0.2229	0.3262
Brugia malayi	Sugar transporter family protein	0.0015	0.0171	0.0122
Trichomonas vaginalis	glucose transporter, putative	0.0034	0.0577	0.2252
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0153	0.0087
Plasmodium falciparum	proline--tRNA ligase	0.0039	0.0671	0.051
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0471	0.6353
Onchocerca volvulus		0.0015	0.0171	0.0122
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0912	0.1247
Schistosoma mansoni	hypothetical protein	0.0313	0.6635	1
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0171	0.0114
Mycobacterium ulcerans	carboxylesterase, LipT	0.0012	0.0096	0.0133
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.005	0.0912	0.1247
Echinococcus granulosus	geminin	0.0172	0.3578	0.5324
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.005	0.0912	0.1247
Echinococcus multilocularis	snurportin 1	0.0313	0.6635	1
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0022	0.0302	0.0967
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0567	0.072
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0368	0.0416
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0178	0.3704	0.3595
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.02	0.2699
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0039	0.0671	0.0909
Trypanosoma brucei	glucose transporter 2A	0.0034	0.0577	0.7781
Trichomonas vaginalis	CAMK family protein kinase	0.0034	0.0567	0.2208
Echinococcus granulosus	serotonin transporter	0.0292	0.6185	0.9312
Toxoplasma gondii	ubiquitin-conjugating enzyme subfamily protein	0.0039	0.0677	0.0917
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0741	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0034	0.0568	0.0404
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0741	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0303	0.0316
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0034	0.0568	0.075
Brugia malayi	Pax transcription factor protein 2	0.0244	0.5151	0.8302
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Onchocerca volvulus		0.0015	0.0171	0.0122
Plasmodium falciparum	ubiquitin-conjugating enzyme E2 N, putative	0.0039	0.0677	0.0515
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.0577	0.7201
Schistosoma mansoni	sugar transporter	0.0015	0.0171	0.0114
Schistosoma mansoni	ran	0.0022	0.0303	0.0316
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0577	0.7781
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0577	0.7781
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0171	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0171	0.0114
Trypanosoma brucei	DNA polymerase IV, putative	0.0035	0.0595	0.8033
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Onchocerca volvulus		0.0015	0.0171	0.0122
Onchocerca volvulus		0.005	0.0912	0.134
Brugia malayi	Sugar transporter family protein	0.011	0.2229	0.3503
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0025	0.0368	0.4971
Onchocerca volvulus		0.0027	0.043	0.0547
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0741	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0042	0.0741	1
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0171	0.127
Trypanosoma cruzi	glucose transporter, putative	0.0015	0.0171	0.0289
Onchocerca volvulus		0.0015	0.0171	0.0122
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.011	0.2229	0.3262
Loa Loa (eye worm)	acetylcholinesterase 1	0.0071	0.1387	0.1975
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0741	1
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.011	0.2229	0.3262
Entamoeba histolytica	hypothetical protein	0.0024	0.035	0.3763
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0171	0.0114
Plasmodium falciparum	lysine--tRNA ligase	0.0025	0.0368	0.0201
Treponema pallidum	sodium- and chloride- dependent transporter	0.0292	0.6185	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0015	0.0154	0.2821
Entamoeba histolytica	ubiquitin-conjugating enzyme family protein	0.0039	0.0677	1
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0368	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0171	0.0114
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0171	0.0114
Leishmania major	lysyl-tRNA synthetase, putative	0.0025	0.0368	0.4108
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0171	0.0348
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.005	0.0912	0.1247
Schistosoma mansoni	protein kinase	0.0034	0.0567	0.072
Echinococcus multilocularis	lamin	0.0027	0.043	0.051
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0039	0.0677	0.2721
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.0577	0.2252
Toxoplasma gondii	hypothetical protein	0.005	0.0912	0.1277
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0313	0.6635	1
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0015	0.0171	0.2301
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0912	0.1247
Schistosoma mansoni	glucose transport protein	0.011	0.2229	0.3262
Echinococcus multilocularis	General substrate transporter	0.0095	0.1892	0.2747
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0034	0.0567	0.0773
Brugia malayi	Carboxylesterase family protein	0.0071	0.1387	0.212
Plasmodium falciparum	importin beta, putative	0.0029	0.0471	0.0305
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0015	0.0154	0.0088
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0171	0.0348
Plasmodium vivax	lysine--tRNA ligase, putative	0.0025	0.0368	0.0201
Schistosoma mansoni	sodium/chloride dependent transporter	0.005	0.0912	0.1247
Echinococcus granulosus	sodium and chloride dependent glycine	0.005	0.0912	0.1247
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0171	0.0114
Leishmania major	GTP-binding protein, putative	0.0022	0.0303	0.285
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0022	0.0303	0.0134
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0912	0.134
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0577	0.7781
Echinococcus granulosus	calcium dependent protein kinase	0.0032	0.0522	0.0651
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0292	0.6185	1
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0021	0.0288	0.9434
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.0299	1
Entamoeba histolytica	protein kinase, putative	0.0034	0.0567	0.7909
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0034	0.0577	0.8089
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0171	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0299	0.4039
Schistosoma mansoni	ubiquitin conjugating enzyme 13	0.0039	0.0677	0.0888
Trypanosoma brucei	unspecified product	0.0035	0.0595	0.8033
Loa Loa (eye worm)	sugar transporter	0.0015	0.0171	0.0114
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0034	0.0567	0.7654
Onchocerca volvulus		0.0015	0.0171	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0171	0.0114
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0033	0.0552	0.0698
Schistosoma mansoni	glucose transporter	0.0015	0.0171	0.0114
Echinococcus granulosus	ubiquitin conjugating enzyme E2 N	0.0039	0.0677	0.0888
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0121	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0552	0.0698
Toxoplasma gondii	protein kinase, putative	0.0311	0.6601	1
Trypanosoma brucei	sugar transporter, putative	0.0015	0.0171	0.2301
Echinococcus multilocularis	dna polymerase eta	0.0015	0.0154	0.0088
Leishmania major	glucose transporter, lmgt3	0.0034	0.0577	0.8089
Onchocerca volvulus		0.0027	0.043	0.0547
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0471	0.0573
Schistosoma mansoni	importin beta-1	0.0029	0.0471	0.0573
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0171	0.127
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Echinococcus granulosus	lamin	0.0027	0.043	0.051
Loa Loa (eye worm)	norepinephrine transporter	0.0292	0.6185	0.9312
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Onchocerca volvulus		0.0015	0.0171	0.0122
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0741	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0912	0.1247
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0121	0.0038
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0034	0.0567	0.072
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0467	1	1
Schistosoma mansoni	hypothetical protein	0.0172	0.3578	0.5324
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0034	0.0568	0.0404
Echinococcus granulosus	solute carrier family 22	0.0015	0.0171	0.0114
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.0577	0.7201
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0033	0.0552	1
Echinococcus granulosus	solute carrier family 22	0.0015	0.0171	0.0114
Echinococcus multilocularis	calcium dependent protein kinase	0.0032	0.0522	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0292	0.6185	0.9312
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.035	0.335
Leishmania major	glucose transporter, lmgt2	0.0034	0.0577	0.8089
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Brugia malayi	Carboxylesterase family protein	0.0071	0.1387	0.212
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0178	0.3704	0.5558
Trypanosoma brucei	unspecified product	0.001	0.0054	0.0732
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.005	0.0912	0.1247
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.005	0.0912	0.1247
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0022	0.0303	0.3459
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0171	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0038
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0033	0.0552	0.7625
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0034	0.0568	0.0404
Entamoeba histolytica	protein kinase, putative	0.0034	0.0567	0.7909
Toxoplasma gondii	sugar transporter ST2	0.0015	0.0171	0.0141
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.005	0.0912	0.1247
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Echinococcus granulosus	dna polymerase kappa	0.0042	0.0741	0.0986
Brugia malayi	hypothetical protein	0.0015	0.0171	0.0122
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0368	0.0416
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0034	0.0568	0.0404
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Echinococcus granulosus	carboxylesterase 5A	0.0071	0.1387	0.1975
Trichomonas vaginalis	glucose transporter, putative	0.0034	0.0577	0.2252
Echinococcus multilocularis	ubiquitin conjugating enzyme E2 N	0.0039	0.0677	0.0888
Brugia malayi	RNA, U transporter 1	0.0083	0.1645	0.2544
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0577	0.7781
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.011	0.2229	0.3262
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0303	0.2538
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Leishmania major	myo-inositol/proton symporter (MIT)	0.0015	0.0171	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0171	0.0114
Leishmania major	ubiquitin-conjugating enzyme e2, putative	0.0039	0.0677	1
Schistosoma mansoni	DNA polymerase eta	0.0015	0.0154	0.0088
Brugia malayi	ImpB/MucB/SamB family protein	0.0015	0.0154	0.0094
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.0741	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.0577	0.7781
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0033	0.0552	0.0698
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0171	0.0114
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.02	0.2699
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0154	0.0088
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.005	0.0912	0.1247
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0034	0.0568	0.0404
Echinococcus multilocularis	geminin	0.0172	0.3578	0.5324
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0034	0.0568	0.0404
Echinococcus granulosus	lysyl tRNA synthetase	0.0025	0.0368	0.0416
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0025	0.0368	0.3657
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0471	0.0573
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.0577	0.2252
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0577	0.7781
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0171	0.0348
Onchocerca volvulus		0.005	0.0912	0.134
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0039	0.0677	0.2721
Schistosoma mansoni	hypothetical protein	0.0172	0.3578	0.5324
Brugia malayi	major facilitator superfamily protein	0.0015	0.0171	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0171	0.0114
Schistosoma mansoni	sugar transporter	0.0015	0.0171	0.0114
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0912	0.1247
Schistosoma mansoni	protein kinase	0.0034	0.0567	0.072
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0015	0.0154	0.0088
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0034	0.0568	0.0404
Leishmania major	importin beta-1 subunit, putative	0.0024	0.035	0.3763
Schistosoma mansoni	sodium-dependent amino acid transporter	0.005	0.0912	0.1247
Plasmodium falciparum	transporter, putative	0.005	0.0912	0.0754
Loa Loa (eye worm)	hypothetical protein	0.005	0.0912	0.1247

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 60 nM	Inhibition of [3H]noradrenalin reuptake at NET expressed in MDCK cells scintillation counting	ChEMBL.	21112782
IC50 (binding)	= 105 nM	Inhibition of [3H]serotonin reuptake at SERT expressed in HEK293 cells scintillation counting	ChEMBL.	21112782
IC50 (binding)	= 173 nM	Inhibition of [3H]dopamine reuptake at DAT expressed in HEK293 cells scintillation counting	ChEMBL.	21112782

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1644606

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1464158