Detailed information for compound 1469158

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 222.305 | Formula: C8H18N2O3S
  • H donors: 3 H acceptors: 3 LogP: -0.85 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC[S+](=N)(CCC(C(=O)O)N)[O-]
  • InChi: 1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7H,2-6,9H2,1H3,(H2-,10,11,12,13)
  • InChiKey: WDFRNLYXRQXXFS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.00510222 0.133946 0.131401
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.00510222 0.133946 0.131401
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.00209184 0.00651306 0.0107475
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0021942 0.0108458 0.0237428
Leishmania major regulatory subunit of protein kinase a-like protein 0.00303389 0.0463907 0.130354
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.00303389 0.0463907 0.0435887
Echinococcus granulosus potassium voltage gated channel subfamily H 0.00699716 0.214161 0.211852
Echinococcus multilocularis G protein coupled receptor 139 0.0255612 1 1
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.00303389 0.0463907 0.0435887
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.00303389 0.0463907 0.0435887
Schistosoma mansoni peptide (allatostatin)-like receptor 0.00510222 0.133946 0.131401
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0021942 0.0108458 0.010609
Brugia malayi Egg laying defective protein 4 0.00303389 0.0463907 0.0563008
Brugia malayi Dopamine receptor protein 2 0.00510222 0.133946 0.16256
Onchocerca volvulus 0.00510222 0.133946 0.397701
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.019634 0.749093 1
Schistosoma mansoni myosin xvIII 0.00510222 0.133946 0.131401
Echinococcus granulosus neuropeptide receptor 0.00510222 0.133946 0.131401
Schistosoma mansoni glutamate-cysteine ligase 0.00988336 0.336337 0.334387
Brugia malayi follicle stimulating hormone receptor 0.00510222 0.133946 0.16256
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0021942 0.0108458 0.0131627
Echinococcus granulosus single minded 2 0.0021942 0.0108458 0.0079393
Loa Loa (eye worm) hypothetical protein 0.0183692 0.695552 0.843581
Trypanosoma cruzi trypanothione reductase, putative 0.00263827 0.0296437 0.0801239
Schistosoma mansoni voltage-gated potassium channel 0.00699716 0.214161 0.211852
Brugia malayi hypothetical protein 0.00510222 0.133946 0.16256
Echinococcus granulosus tm gpcr rhodopsin 0.00510222 0.133946 0.131401
Trichomonas vaginalis guanylate cyclase, putative 0.0021942 0.0108458 0.010609
Echinococcus granulosus 7tm_1 domain containing protein 0.00510222 0.133946 0.131401
Echinococcus granulosus cyclic nucleotide gated cation channel 0.00480296 0.121278 0.118696
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.00209184 0.00651306 0.00359383
Schistosoma mansoni opsin-like receptor 0.00510222 0.133946 0.131401
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.00303389 0.0463907 0.130354
Mycobacterium ulcerans hypothetical protein 0.00303389 0.0463907 0.0478367
Trichomonas vaginalis adenylate cyclase type III, putative 0.0021942 0.0108458 0.010609
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0021942 0.0108458 0.010609
Trichomonas vaginalis guanylate cyclase, putative 0.0021942 0.0108458 0.010609
Trichomonas vaginalis adenylate cyclase, putative 0.0021942 0.0108458 0.010609
Trichomonas vaginalis adenylate cyclase type III, putative 0.0021942 0.0108458 0.010609
Echinococcus multilocularis fmrfamide receptor 0.00510222 0.133946 0.131401
Entamoeba histolytica P-glyco protein 6, putative 0.00209184 0.00651306 1
Trichomonas vaginalis adenylate cyclase type vIII, putative 0.0021942 0.0108458 0.010609
Trichomonas vaginalis adenylate cyclase, putative 0.0021942 0.0108458 0.010609
Schistosoma mansoni growth hormone secretagogue receptor 0.00510222 0.133946 0.131401
Brugia malayi G protein-coupled receptor 0.00510222 0.133946 0.16256
Schistosoma mansoni similar to Protein C20orf152 homolog 0.00303389 0.0463907 0.0435887
Brugia malayi ABC transporter family protein 0.00209184 0.00651306 0.00790439
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.00303389 0.0463907 0.130354
Loa Loa (eye worm) hypothetical protein 0.00303389 0.0463907 0.0529334
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.00303389 0.0463907 0.120906
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00510222 0.133946 0.131401
Schistosoma mansoni amine GPCR 0.00510222 0.133946 0.131401
Mycobacterium leprae Conserved hypothetical protein 0.00303389 0.0463907 1
Echinococcus granulosus g protein coupled receptor 0.00510222 0.133946 0.131401
Echinococcus granulosus rhodopsin orphan GPCR 0.00510222 0.133946 0.131401
Onchocerca volvulus 0.00510222 0.133946 0.397701
Echinococcus granulosus neuropeptide Y receptor 0.00510222 0.133946 0.131401
Loa Loa (eye worm) follicle stimulating hormone receptor 0.00510222 0.133946 0.159571
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.00209184 0.00651306 0.0048023
Trichomonas vaginalis adenylate cyclase type, putative 0.0021942 0.0108458 0.010609
Trichomonas vaginalis guanylate cyclase, putative 0.0021942 0.0108458 0.010609
Brugia malayi Thioredoxin reductase 0.00761339 0.240247 0.291569
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.00303389 0.0463907 0.130354
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.00480296 0.121278 0.118696
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0021942 0.0108458 0.010609
Echinococcus multilocularis voltage gated potassium channel 0.00699716 0.214161 0.211852
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.00303389 0.0463907 0.137145
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.00209184 0.00651306 0.0048023
Treponema pallidum catabolite gene activator 0.00303389 0.0463907 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.00209184 0.00651306 0.0048023
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.00209184 0.00651306 0.00359383
Trichomonas vaginalis conserved hypothetical protein 0.0021942 0.0108458 0.010609
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Schistosoma mansoni serine/threonine protein kinase 0.00303389 0.0463907 0.0435887
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Mycobacterium ulcerans flavoprotein disulfide reductase 0.00263827 0.0296437 0.0294035
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Echinococcus granulosus cGMP dependent protein kinase 1 0.00303389 0.0463907 0.0435887
Schistosoma mansoni serine/threonine protein kinase 0.00303389 0.0463907 0.0435887
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.00209184 0.00651306 0.0048023
Schistosoma mansoni neuropeptide receptor 0.0255612 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0021942 0.0108458 0.010609
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.00209184 0.00651306 0.0048023
Loa Loa (eye worm) hypothetical protein 0.00699716 0.214161 0.25727
Mycobacterium ulcerans hypothetical protein 0.00303389 0.0463907 0.0478367
Echinococcus granulosus multidrug resistance protein 1 0.00209184 0.00651306 0.00359383
Trichomonas vaginalis guanylate cyclase, putative 0.0021942 0.0108458 0.010609
Giardia lamblia Glutamate-cysteine ligase 0.00988336 0.336337 1
Echinococcus granulosus tm gpcr rhodopsin 0.00510222 0.133946 0.131401
Schistosoma mansoni adenoreceptor 0.00510222 0.133946 0.131401
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.00510222 0.133946 0.16256
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00480296 0.121278 0.118696
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.00303389 0.0463907 0.130354
Echinococcus multilocularis alpha 1A adrenergic receptor 0.00510222 0.133946 0.131401
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.00303389 0.0463907 0.0440664
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00510222 0.133946 0.131401
Schistosoma mansoni multidrug resistance protein 0.00209184 0.00651306 0.00359383
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.00263827 0.0296437 0.5
Echinococcus multilocularis serotonin receptor 0.00510222 0.133946 0.131401
Trichomonas vaginalis guanylate cyclase beta 2 subunit, putative 0.0021942 0.0108458 0.010609
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Schistosoma mansoni neuropeptide F-like receptor 0.00510222 0.133946 0.131401
Schistosoma mansoni amine GPCR 0.00510222 0.133946 0.131401
Brugia malayi RE15519p 0.00510222 0.133946 0.16256
Trichomonas vaginalis guanylate cyclase, putative 0.0021942 0.0108458 0.010609
Mycobacterium ulcerans epoxide hydrolase EphA 0.0234696 0.911458 1
Schistosoma mansoni neuropeptide receptor 0.00510222 0.133946 0.131401
Trichomonas vaginalis guanylate cyclase, putative 0.0021942 0.0108458 0.010609
Trypanosoma brucei gamma-glutamylcysteine synthetase 0.00988336 0.336337 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.00480296 0.121278 0.118696
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.00303389 0.0463907 0.0435887
Trichomonas vaginalis glutathione reductase, putative 0.00263827 0.0296437 0.0358017
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.00510222 0.133946 0.131401
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00510222 0.133946 0.131401
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.00510222 0.133946 0.131401
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0021942 0.0108458 0.010609
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Onchocerca volvulus 0.00510222 0.133946 0.397701
Leishmania major trypanothione reductase 0.00761339 0.240247 0.711792
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.00510222 0.133946 0.16256
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.00480296 0.121278 0.118696
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.00510222 0.133946 0.131401
Echinococcus granulosus tachykinin peptides receptor 99D 0.00510222 0.133946 0.131401
Leishmania major gamma-glutamylcysteine synthetase, putative 0.00988336 0.336337 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0214031 0.82398 1
Echinococcus granulosus rhodopsin orphan GPCR 0.00510222 0.133946 0.131401
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.00263827 0.0296437 0.0801239
Echinococcus multilocularis rhodopsin orphan GPCR 0.00510222 0.133946 0.131401
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.00209184 0.00651306 0.00359383
Schistosoma mansoni neuropeptide F-like receptor 0.00510222 0.133946 0.131401
Plasmodium vivax glutathione reductase, putative 0.00761339 0.240247 0.711792
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00510222 0.133946 0.131401
Schistosoma mansoni opsin-like receptor 0.00510222 0.133946 0.131401
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Trichomonas vaginalis adenylate cyclase, putative 0.0021942 0.0108458 0.010609
Echinococcus granulosus orexin receptor type 2 0.00510222 0.133946 0.131401
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.00209184 0.00651306 0.0048023
Mycobacterium ulcerans transmembrane transport protein 0.00303389 0.0463907 0.0478367
Echinococcus granulosus rhodopsin orphan GPCR 0.00510222 0.133946 0.131401
Plasmodium vivax thioredoxin reductase, putative 0.00761339 0.240247 0.711792
Echinococcus multilocularis g protein coupled receptor 0.00510222 0.133946 0.131401
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.00303389 0.0463907 0.0435887
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0214031 0.82398 0.823462
Trypanosoma cruzi cAMP response protein 1, putative 0.00303389 0.0463907 0.130354
Brugia malayi hypothetical protein 0.00510222 0.133946 0.16256
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.00303389 0.0463907 1
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Loa Loa (eye worm) melatonin receptor type 1A 0.00510222 0.133946 0.159571
Brugia malayi Tachykinin-like peptides receptor 99D 0.00510222 0.133946 0.16256
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Trypanosoma cruzi gamma-glutamylcysteine synthetase, putative 0.00988336 0.336337 1
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Echinococcus granulosus thioredoxin glutathione reductase 0.00761339 0.240247 0.238014
Echinococcus granulosus peptide allatostatin:somatostatin 0.00510222 0.133946 0.131401
Mycobacterium ulcerans hypothetical protein 0.00303389 0.0463907 0.0478367
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Brugia malayi Cyclic-nucleotide gated cation channel 0.00480296 0.121278 0.147186
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.00510222 0.133946 0.131401
Brugia malayi G-protein coupled receptor 0.00510222 0.133946 0.16256
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.00510222 0.133946 0.131401
Echinococcus multilocularis neuropeptide Y receptor 0.00510222 0.133946 0.131401
Echinococcus granulosus 7TM GPCR rhodopsin 0.00510222 0.133946 0.131401
Onchocerca volvulus 0.00510222 0.133946 0.397701
Leishmania major protein kinase, putative 0.00303389 0.0463907 0.130354
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Trichomonas vaginalis guanylate cyclase, putative 0.0021942 0.0108458 0.010609
Echinococcus multilocularis neuropeptide Y receptor 0.00510222 0.133946 0.131401
Schistosoma mansoni amine GPCR 0.00510222 0.133946 0.131401
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.00510222 0.133946 0.131401
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.00510222 0.133946 0.131401
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0021942 0.0108458 0.010609
Echinococcus granulosus g protein coupled receptor 0.00510222 0.133946 0.131401
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.00480296 0.121278 0.144142
Echinococcus granulosus thyrotropin releasing hormone receptor 0.00510222 0.133946 0.131401
Echinococcus multilocularis ATP binding cassette sub family B 0.00208582 0.00625791 0.00333793
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.00480296 0.121278 0.118696
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Echinococcus multilocularis neuropeptides capa receptor 0.00510222 0.133946 0.131401
Onchocerca volvulus 0.00209184 0.00651306 0.0184729
Echinococcus granulosus tm gpcr rhodopsin 0.00510222 0.133946 0.131401
Trichomonas vaginalis ABC transporter, putative 0.00209184 0.00651306 0.0048023
Brugia malayi G protein-coupled receptor F59B2.13 0.00510222 0.133946 0.16256
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00510222 0.133946 0.131401
Echinococcus granulosus cyclic nucleotide gated cation channel 0.00303389 0.0463907 0.0435887
Treponema pallidum cyclic nucleotide binding protein 0.00303389 0.0463907 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.00209184 0.00651306 0.00359383
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.00263827 0.0296437 0.0801239
Leishmania major cyclic nucleotide-binding protein-like protein 0.00303389 0.0463907 0.130354
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Schistosoma mansoni voltage-gated potassium channel 0.0235973 0.916863 0.916618
Brugia malayi hypothetical protein 0.00510222 0.133946 0.16256
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.00263827 0.0296437 0.0267924
Trichomonas vaginalis adenylate cyclase, putative 0.0021942 0.0108458 0.010609
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0021942 0.0108458 0.010609
Trichomonas vaginalis conserved hypothetical protein 0.0021942 0.0108458 0.010609
Trichomonas vaginalis guanylate cyclase, putative 0.0021942 0.0108458 0.010609
Echinococcus multilocularis neuropeptides capa receptor 0.00510222 0.133946 0.131401
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.019634 0.749093 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.00263827 0.0296437 0.0701301
Echinococcus multilocularis g protein coupled receptor 0.00510222 0.133946 0.131401
Trichomonas vaginalis adenylate cyclase type VI, putative 0.0021942 0.0108458 0.010609
Echinococcus multilocularis multidrug resistance protein 1 0.00209184 0.00651306 0.00359383
Onchocerca volvulus 0.00510222 0.133946 0.397701
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00510222 0.133946 0.131401
Echinococcus multilocularis orexin receptor type 2 0.00510222 0.133946 0.131401
Echinococcus multilocularis hyperpolarization activated cyclic 0.00480296 0.121278 0.118696
Trichomonas vaginalis guanylate cyclase, putative 0.0021942 0.0108458 0.010609
Mycobacterium ulcerans regulatory protein 0.00303389 0.0463907 0.0478367
Echinococcus granulosus cGMP dependent protein kinase 0.00303389 0.0463907 0.0435887
Trichomonas vaginalis guanylate cyclase, putative 0.0021942 0.0108458 0.010609
Mycobacterium tuberculosis Conserved hypothetical protein 0.00303389 0.0463907 0.0440664
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0021942 0.0108458 0.010609
Echinococcus multilocularis serotonin receptor 0.00510222 0.133946 0.131401
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Schistosoma mansoni neuropeptide f receptor 76f 0.00510222 0.133946 0.131401
Echinococcus granulosus neuropeptide receptor 0.0255612 1 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.00263827 0.0296437 0.0801239
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.00263827 0.0296437 0.0801239
Echinococcus multilocularis multidrug resistance protein 1 0.00209184 0.00651306 0.00359383
Schistosoma mansoni voltage-gated potassium channel 0.0235973 0.916863 0.916618
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.00303389 0.0463907 0.130354
Leishmania major hypothetical protein, conserved 0.00303389 0.0463907 0.130354
Trypanosoma brucei trypanothione reductase 0.00761339 0.240247 0.711792
Trichomonas vaginalis adenylate cyclase, putative 0.0021942 0.0108458 0.010609
Echinococcus granulosus cGMP dependent protein kinase 1 0.00303389 0.0463907 0.0435887
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.00209184 0.00651306 0.00359383
Trichomonas vaginalis ABC transporter, half transporter, putative 0.00209184 0.00651306 0.0048023
Echinococcus granulosus rhodopsin orphan GPCR 0.00510222 0.133946 0.131401
Echinococcus granulosus hypothetical protein 0.00510222 0.133946 0.131401
Schistosoma mansoni 60S ribosomal protein L21 0.00396327 0.0857329 0.0830465
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.00303389 0.0463907 0.058246
Schistosoma mansoni amine GPCR 0.00510222 0.133946 0.131401
Onchocerca volvulus 0.00510222 0.133946 0.397701
Trypanosoma brucei cAMP response protein 1, putative 0.00303389 0.0463907 0.130354
Onchocerca volvulus 0.00510222 0.133946 0.397701
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.00303389 0.0463907 0.0563008
Trichomonas vaginalis adenylate cyclase, putative 0.0021942 0.0108458 0.010609
Entamoeba histolytica P-glycoprotein-2 0.00209184 0.00651306 1
Echinococcus multilocularis neuropeptide receptor A26 0.00510222 0.133946 0.131401
Plasmodium vivax gamma-glutamylcysteine synthetase, putative 0.00988336 0.336337 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.00263827 0.0296437 0.0801239
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Schistosoma mansoni biogenic amine (5HT) receptor 0.00510222 0.133946 0.131401
Echinococcus granulosus neuropeptides capa receptor 0.00510222 0.133946 0.131401
Loa Loa (eye worm) glutamate-cysteine ligase 0.00988336 0.336337 0.406075
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.00303389 0.0463907 0.120906
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00303389 0.0463907 0.058246
Entamoeba histolytica P-glycoprotein-1 0.00209184 0.00651306 1
Entamoeba histolytica P-glycoprotein 5, putative 0.00209184 0.00651306 1
Trichomonas vaginalis adenylyl cyclase type V, putative 0.0021942 0.0108458 0.010609
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.00263827 0.0296437 0.0801239
Echinococcus multilocularis hyperpolarization activated cyclic 0.00480296 0.121278 0.118696
Echinococcus multilocularis glutamate cysteine ligase, catalytic subunit 0.00988336 0.336337 0.334387
Trichomonas vaginalis conserved hypothetical protein 0.0021942 0.0108458 0.010609
Trichomonas vaginalis guanylate cyclase, putative 0.0021942 0.0108458 0.010609
Loa Loa (eye worm) TYRA-2 protein 0.00510222 0.133946 0.159571
Trichomonas vaginalis hypothetical protein 0.0021942 0.0108458 0.010609
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.00209184 0.00651306 0.0048023
Brugia malayi hypothetical protein 0.00510222 0.133946 0.16256
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00510222 0.133946 0.131401
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Plasmodium falciparum gamma-glutamylcysteine synthetase 0.00988336 0.336337 1
Loa Loa (eye worm) hypothetical protein 0.00208582 0.00625791 0.00405353
Trichomonas vaginalis abcb9, putative 0.00209184 0.00651306 0.0048023
Onchocerca volvulus 0.00510222 0.133946 0.397701
Schistosoma mansoni hypothetical protein 0.0021942 0.0108458 0.0079393
Trichomonas vaginalis adenylate cyclase, putative 0.0021942 0.0108458 0.010609
Onchocerca volvulus 0.00303389 0.0463907 0.137145
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.00699716 0.214161 0.211852
Treponema pallidum catabolite gene activator (Crp) 0.00303389 0.0463907 1
Brugia malayi hypothetical protein 0.00510222 0.133946 0.16256
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.00209184 0.00651306 0.00436429
Loa Loa (eye worm) glutathione reductase 0.00761339 0.240247 0.289041
Leishmania major dihydrolipoamide dehydrogenase, putative 0.00263827 0.0296437 0.0801239
Loa Loa (eye worm) multidrug resistance protein 3 0.00209184 0.00651306 0.00436429
Trypanosoma brucei Flagellar Member 6 0.00303389 0.0463907 0.130354
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0020072 0.00292976 0.00355562
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00510222 0.133946 0.131401
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.00209184 0.00651306 0.00359383
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00510222 0.133946 0.131401
Trichomonas vaginalis guanylate cyclase, putative 0.0021942 0.0108458 0.010609
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Trypanosoma cruzi protein kinase A regulatory subunit 0.00303389 0.0463907 0.130354
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.00303389 0.0463907 0.0435887
Echinococcus multilocularis neuropeptide FF receptor 2 0.00510222 0.133946 0.131401
Trypanosoma cruzi cAMP binding protein, putative 0.00303389 0.0463907 0.130354
Plasmodium falciparum thioredoxin reductase 0.00263827 0.0296437 0.0801239
Echinococcus granulosus rhodopsin orphan GPCR 0.00510222 0.133946 0.131401
Brugia malayi Serotonin receptor 0.00510222 0.133946 0.16256
Trichomonas vaginalis adenylate cyclase, putative 0.0021942 0.0108458 0.010609
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Loa Loa (eye worm) neuropeptide F receptor 0.00510222 0.133946 0.159571
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Trichomonas vaginalis ABC transporter, half transporter, putative 0.00209184 0.00651306 0.0048023
Trichomonas vaginalis conserved hypothetical protein 0.00303389 0.0463907 0.058246
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0234696 0.911458 1
Echinococcus granulosus hyperpolarization activated cyclic 0.00480296 0.121278 0.118696
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0021942 0.0108458 0.010609
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0021942 0.0108458 0.010609
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00510222 0.133946 0.131401
Trichomonas vaginalis adenylate cyclase, putative 0.0021942 0.0108458 0.010609
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.00510222 0.133946 0.131401
Trypanosoma brucei cAMP binding protein, putative 0.00303389 0.0463907 0.130354
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0021942 0.0108458 0.010609
Echinococcus multilocularis g-protein coupled receptor 0.00510222 0.133946 0.131401
Brugia malayi Dopamine receptor protein 1 0.00510222 0.133946 0.16256
Trichomonas vaginalis abcb9, putative 0.00209184 0.00651306 0.0048023
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.00209184 0.00651306 0.0048023
Echinococcus granulosus rhodopsin orphan GPCR 0.00510222 0.133946 0.131401
Loa Loa (eye worm) hypothetical protein 0.00209184 0.00651306 0.00436429
Trypanosoma brucei protein kinase A regulatory subunit 0.00303389 0.0463907 0.130354
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.00510222 0.133946 0.159571
Echinococcus granulosus neuropeptide Y receptor 0.00510222 0.133946 0.131401
Echinococcus granulosus G protein coupled receptor 139 0.00510222 0.133946 0.131401
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0021942 0.0108458 0.010609
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.00480296 0.121278 0.144142
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.00209184 0.00651306 0.0048023
Onchocerca volvulus 0.00510222 0.133946 0.397701
Echinococcus granulosus sex peptide receptor 0.00510222 0.133946 0.131401
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.00510222 0.133946 0.131401
Trypanosoma cruzi Flagellar Member 6 0.00303389 0.0463907 0.130354
Trichomonas vaginalis adenylate cyclase, putative 0.0021942 0.0108458 0.010609
Echinococcus multilocularis G-protein coupled receptor, putative 0.00510222 0.133946 0.131401
Onchocerca volvulus 0.00510222 0.133946 0.397701
Trichomonas vaginalis adenylate cyclase type, putative 0.0021942 0.0108458 0.010609
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.00209184 0.00651306 0.0048023
Echinococcus granulosus neuropeptide s receptor 0.00510222 0.133946 0.131401
Leishmania major hypothetical protein, unknown function 0.00303389 0.0463907 0.130354
Trichomonas vaginalis guanylate cyclase, putative 0.0021942 0.0108458 0.010609
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.00263827 0.0296437 0.0255603
Trichomonas vaginalis adenylate cyclase, putative 0.0021942 0.0108458 0.010609
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0021942 0.0108458 0.010609
Treponema pallidum NADH oxidase 0.00263827 0.0296437 0.614664
Trichomonas vaginalis guanylate cyclase, putative 0.0021942 0.0108458 0.010609
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.00303389 0.0463907 0.0563008
Schistosoma mansoni opsin-like receptor 0.00510222 0.133946 0.131401
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00480296 0.121278 0.118696
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.00303389 0.0463907 0.0435887
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.00209184 0.00651306 0.0048023
Echinococcus granulosus fmrfamide receptor 0.00510222 0.133946 0.131401
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00510222 0.133946 0.131401
Schistosoma mansoni voltage-gated potassium channel 0.00699716 0.214161 0.211852
Brugia malayi glutathione reductase 0.00761339 0.240247 0.291569
Schistosoma mansoni neuropeptide receptor 0.00510222 0.133946 0.131401
Schistosoma mansoni amine GPCR 0.00510222 0.133946 0.131401
Echinococcus granulosus hyperpolarization activated cyclic 0.00480296 0.121278 0.118696
Brugia malayi putative neuropeptide receptor NPR1 0.00510222 0.133946 0.16256
Trichomonas vaginalis ABC transporter, putative 0.00209184 0.00651306 0.0048023
Plasmodium falciparum thioredoxin reductase 0.00761339 0.240247 0.711792
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00510222 0.133946 0.131401
Echinococcus multilocularis neuropeptide receptor 0.0255612 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.00510222 0.133946 0.397701
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0021942 0.0108458 0.010609
Echinococcus multilocularis dro:myosuppressin receptor 0.00510222 0.133946 0.131401
Trichomonas vaginalis conserved hypothetical protein 0.0021942 0.0108458 0.010609
Trichomonas vaginalis ABC transporter, putative 0.00209184 0.00651306 0.0048023
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0214031 0.82398 0.823462
Leishmania major hypothetical protein, conserved 0.00303389 0.0463907 0.130354
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.00303991 0.0466459 0.0443484
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.00263827 0.0296437 0.528848
Mycobacterium tuberculosis Conserved hypothetical protein 0.00303389 0.0463907 0.0440664
Echinococcus multilocularis rhodopsin orphan GPCR 0.00510222 0.133946 0.131401
Schistosoma mansoni hypothetical protein 0.00510222 0.133946 0.131401
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.00263827 0.0296437 0.0801239
Brugia malayi N-terminal motif family protein 0.00303389 0.0463907 0.0563008
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.00263827 0.0296437 0.0255603
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.00263827 0.0296437 0.0359762
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.00303389 0.0463907 0.0440664
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.00303389 0.0463907 0.0435887
Echinococcus granulosus biogenic amine 5HT receptor 0.00510222 0.133946 0.131401
Loa Loa (eye worm) G-protein coupled receptor 0.00510222 0.133946 0.159571
Trichomonas vaginalis guanylate cyclase, putative 0.0021942 0.0108458 0.010609
Onchocerca volvulus 0.00510222 0.133946 0.397701
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.00699716 0.214161 0.25991
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.00510222 0.133946 0.131401
Echinococcus multilocularis rhodopsin orphan GPCR 0.00510222 0.133946 0.131401
Echinococcus granulosus multidrug resistance protein 1 0.00209184 0.00651306 0.00359383
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Schistosoma mansoni multidrug resistance protein 0.00209184 0.00651306 0.00359383
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0021942 0.0108458 0.010609
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.00209184 0.00651306 0.0048023
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.00303389 0.0463907 0.0435887
Echinococcus granulosus g protein coupled receptor 0.00510222 0.133946 0.131401
Trichomonas vaginalis guanylate cyclase, putative 0.0021942 0.0108458 0.010609
Echinococcus multilocularis biogenic amine (5HT) receptor 0.00510222 0.133946 0.131401
Brugia malayi gonadotropin-releasing hormone receptor 2 0.00510222 0.133946 0.16256
Loa Loa (eye worm) hypothetical protein 0.00209184 0.00651306 0.00436429
Onchocerca volvulus 0.00510222 0.133946 0.397701
Schistosoma mansoni biogenic amine receptor 0.00510222 0.133946 0.131401
Trichomonas vaginalis intestinal guanylate cyclase, putative 0.0021942 0.0108458 0.010609
Onchocerca volvulus 0.00510222 0.133946 0.397701
Brugia malayi hypothetical protein 0.00510222 0.133946 0.16256
Loa Loa (eye worm) hypothetical protein 0.00303389 0.0463907 0.0529334
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0021942 0.0108458 0.010609
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.00209184 0.00651306 0.0048023
Trichomonas vaginalis conserved hypothetical protein 0.0021942 0.0108458 0.010609
Echinococcus granulosus serotonin receptor 0.00510222 0.133946 0.131401
Brugia malayi AKH receptor 0.00510222 0.133946 0.16256
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.00480296 0.121278 0.118696
Trichomonas vaginalis mercuric reductase, putative 0.00263827 0.0296437 0.0358017
Brugia malayi hypothetical protein 0.00510222 0.133946 0.16256
Plasmodium falciparum glutathione reductase 0.00761339 0.240247 0.711792
Echinococcus multilocularis patatin phospholipase domain containing protein 0.00303389 0.0463907 0.0435887
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00510222 0.133946 0.131401
Trichomonas vaginalis guanylate cyclase, putative 0.0021942 0.0108458 0.010609
Trichomonas vaginalis conserved hypothetical protein 0.0021942 0.0108458 0.010609
Echinococcus multilocularis rhodopsin orphan GPCR 0.00510222 0.133946 0.131401
Brugia malayi Serotonin receptor 0.00510222 0.133946 0.16256
Trichomonas vaginalis adenylate cyclase, putative 0.0021942 0.0108458 0.010609
Loa Loa (eye worm) neuropeptide F receptor 0.00510222 0.133946 0.159571
Trichomonas vaginalis adenylate cyclase, putative 0.0021942 0.0108458 0.010609
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.00303389 0.0463907 0.0440664
Trichomonas vaginalis ABC transporter, putative 0.00209184 0.00651306 0.0048023
Schistosoma mansoni hypothetical protein 0.00510222 0.133946 0.131401
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.00263827 0.0296437 0.580039
Trichomonas vaginalis adenylate cyclase type, putative 0.0021942 0.0108458 0.010609
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.00263827 0.0296437 0.0294035
Brugia malayi neuropeptide F receptor 0.00510222 0.133946 0.16256
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00510222 0.133946 0.131401
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.00263827 0.0296437 0.0801239
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.00510222 0.133946 0.131401
Brugia malayi glutamate--cysteine ligase 0.00988336 0.336337 0.408186
Leishmania major acetoin dehydrogenase e3 component-like protein 0.00263827 0.0296437 0.0801239
Mycobacterium ulcerans transcriptional regulatory protein 0.00303389 0.0463907 0.0478367
Toxoplasma gondii NADPH-glutathione reductase 0.00263827 0.0296437 0.0701301
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.00209184 0.00651306 0.0048023
Brugia malayi hypothetical protein 0.00510222 0.133946 0.16256
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00510222 0.133946 0.131401
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.00303389 0.0463907 0.130354
Onchocerca volvulus 0.00510222 0.133946 0.397701
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Trichomonas vaginalis conserved hypothetical protein 0.0021942 0.0108458 0.010609
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.00263827 0.0296437 0.0267924
Onchocerca volvulus 0.00510222 0.133946 0.397701
Echinococcus granulosus neuropeptides capa receptor 0.00510222 0.133946 0.131401
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0021942 0.0108458 0.010609
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.00303389 0.0463907 0.0435887
Schistosoma mansoni serine/threonine protein kinase 0.00303389 0.0463907 0.0435887
Trichomonas vaginalis taga, putative 0.00209184 0.00651306 0.0048023
Loa Loa (eye worm) hypothetical protein 0.00480296 0.121278 0.144142
Onchocerca volvulus 0.00510222 0.133946 0.397701
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.00303389 0.0463907 0.0435887
Trichomonas vaginalis conserved hypothetical protein 0.0021942 0.0108458 0.010609
Echinococcus granulosus glutamate cysteine ligase catalytic subunit 0.00988336 0.336337 0.334387
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.00263827 0.0296437 0.0801239
Treponema pallidum cyclic nucleotide binding protein 0.00303389 0.0463907 1
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.00303389 0.0463907 0.0435887
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.00510222 0.133946 0.131401
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.00263827 0.0296437 0.0267924
Echinococcus granulosus alpha 1A adrenergic receptor 0.00510222 0.133946 0.131401
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.00761339 0.240247 0.258285
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00303389 0.0463907 0.0435887
Echinococcus granulosus dro:myosuppressin receptor 0.00510222 0.133946 0.131401
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.00510222 0.133946 0.159571
Leishmania major p-glycoprotein 0.00209184 0.00651306 0.0107475
Echinococcus multilocularis thioredoxin glutathione reductase 0.00761339 0.240247 0.238014
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00510222 0.133946 0.131401
Schistosoma mansoni hypothetical protein 0.00510222 0.133946 0.131401
Echinococcus granulosus somatostatin receptor 0.00510222 0.133946 0.131401
Echinococcus granulosus allatostatin A receptor 0.00510222 0.133946 0.131401
Schistosoma mansoni biogenic amine (5HT) receptor 0.00510222 0.133946 0.131401
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.00263827 0.0296437 0.0801239
Schistosoma mansoni histamine h1 receptor 0.00510222 0.133946 0.131401
Schistosoma mansoni biogenic amine receptor 0.00510222 0.133946 0.131401
Schistosoma mansoni neuropeptide receptor 0.00510222 0.133946 0.131401
Schistosoma mansoni biogenic amine receptor 0.00510222 0.133946 0.131401
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.00303389 0.0463907 0.130354
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.00303389 0.0463907 0.0435887
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.00263827 0.0296437 0.0294035
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.00480296 0.121278 0.118696
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.00510222 0.133946 0.159571
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.00510222 0.133946 0.16256
Schistosoma mansoni multidrug resistance protein 0.00209184 0.00651306 0.00359383
Trichomonas vaginalis conserved hypothetical protein 0.0021942 0.0108458 0.010609
Brugia malayi Dopamine receptor 0.00510222 0.133946 0.16256
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.00303389 0.0463907 0.0563008
Trichomonas vaginalis abcb9, putative 0.00209184 0.00651306 0.0048023
Brugia malayi sulfakinin receptor protein 0.00510222 0.133946 0.16256
Echinococcus multilocularis cGMP dependent protein kinase 1 0.00303389 0.0463907 0.0435887
Brugia malayi hypothetical protein 0.00510222 0.133946 0.16256
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.00303389 0.0463907 0.0529334
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.00263827 0.0296437 0.0801239
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.00303389 0.0463907 0.058246
Entamoeba histolytica P-glycoprotein-2, putative 0.00209184 0.00651306 1
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.00303389 0.0463907 0.120906
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.00263827 0.0296437 0.0255603
Schistosoma mansoni voltage-gated potassium channel 0.00480296 0.121278 0.118696
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.00510222 0.133946 0.131401
Echinococcus multilocularis cGMP dependent protein kinase 1 0.00303389 0.0463907 0.0435887
Echinococcus multilocularis neuropeptide receptor 0.00510222 0.133946 0.131401
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.00510222 0.133946 0.159571
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.00510222 0.133946 0.397701
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.00263827 0.0296437 0.0801239
Leishmania major dihydrolipoamide dehydrogenase, putative 0.00263827 0.0296437 0.0801239
Echinococcus multilocularis rhodopsin orphan GPCR 0.00510222 0.133946 0.131401
Echinococcus multilocularis rhodopsin orphan GPCR 0.00510222 0.133946 0.131401
Loa Loa (eye worm) thioredoxin reductase 0.00761339 0.240247 0.289041
Leishmania major protein kinase, putative 0.00303389 0.0463907 0.130354
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.00303389 0.0463907 0.130354
Entamoeba histolytica P-glycoprotein-2 0.00209184 0.00651306 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.00209184 0.00651306 0.00359383
Echinococcus granulosus rhodopsin orphan GPCR 0.00510222 0.133946 0.131401
Brugia malayi hypothetical protein 0.00510222 0.133946 0.16256
Schistosoma mansoni hypothetical protein 0.00303389 0.0463907 0.0435887
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.00209184 0.00651306 0.0048023
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.00303389 0.0463907 0.0435887
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00510222 0.133946 0.131401
Schistosoma mansoni voltage-gated potassium channel 0.00396327 0.0857329 0.0830465
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Leishmania major hypothetical protein, conserved 0.00303389 0.0463907 0.130354
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.00480296 0.121278 0.118696
Echinococcus granulosus multidrug resistance protein 1 0.00209184 0.00651306 0.00359383
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.00303389 0.0463907 0.130354
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.00480296 0.121278 0.118696
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.00303389 0.0463907 0.0435887
Loa Loa (eye worm) AGC/PKG protein kinase 0.00303389 0.0463907 0.0529334
Echinococcus granulosus patatin phospholipase domain containing protein 0.00303389 0.0463907 0.0435887
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0020072 0.00292976 0.00355562
Echinococcus granulosus g-protein coupled receptor 0.00510222 0.133946 0.131401
Leishmania major protein kinase A regulatory subunit, putative 0.00303389 0.0463907 0.130354
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.00208582 0.00625791 0.00333793
Echinococcus granulosus biogenic amine 5HT receptor 0.00510222 0.133946 0.131401
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.00303389 0.0463907 0.0435887
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.00303389 0.0463907 0.120906
Echinococcus multilocularis expressed conserved protein 0.00303389 0.0463907 0.0435887
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00510222 0.133946 0.131401
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Trypanosoma cruzi trypanothione reductase, putative 0.00761339 0.240247 0.711792
Brugia malayi multidrug resistance protein 3 0.00209184 0.00651306 0.00790439
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00510222 0.133946 0.131401
Echinococcus multilocularis tachykinin peptides receptor 99D 0.00510222 0.133946 0.131401
Trichomonas vaginalis guanylate cyclase, putative 0.0021942 0.0108458 0.010609
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.00263827 0.0296437 0.0801239
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.00209184 0.00651306 0.00359383
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00510222 0.133946 0.131401
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.00263827 0.0296437 0.0801239
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0214031 0.82398 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.00209184 0.00651306 0.0048023
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.00303389 0.0463907 0.0435887
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.00303389 0.0463907 0.120906
Echinococcus multilocularis rhodopsin orphan GPCR 0.00510222 0.133946 0.131401
Mycobacterium tuberculosis Conserved protein 0.00303389 0.0463907 0.0440664
Trichomonas vaginalis guanylate cyclase, putative 0.0021942 0.0108458 0.010609
Trichomonas vaginalis adenylate cyclase, putative 0.0021942 0.0108458 0.010609
Trypanosoma cruzi hypothetical protein, conserved 0.00303389 0.0463907 0.130354
Entamoeba histolytica P-glycoprotein-5 0.00209184 0.00651306 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00303389 0.0463907 0.058246
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.00303389 0.0463907 0.0435887
Schistosoma mansoni alpha-1 adrenergic receptor 0.00510222 0.133946 0.131401
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00510222 0.133946 0.131401
Plasmodium falciparum multidrug resistance protein 1 0.00209184 0.00651306 0.0107475
Schistosoma mansoni hypothetical protein 0.00510222 0.133946 0.131401
Echinococcus multilocularis sex peptide receptor 0.00510222 0.133946 0.131401
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.00263827 0.0296437 0.0801239
Trypanosoma cruzi gamma-glutamylcysteine synthetase, putative 0.00988336 0.336337 1
Plasmodium vivax multidrug resistance protein 1, putative 0.00209184 0.00651306 0.0107475
Brugia malayi G-protein coupled receptor 0.00510222 0.133946 0.16256
Plasmodium falciparum glutathione reductase 0.00263827 0.0296437 0.0801239
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Echinococcus multilocularis g protein coupled receptor 0.00510222 0.133946 0.131401
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.00209184 0.00651306 0.0048023
Trichomonas vaginalis guanylate cyclase beta 1 subunit, putative 0.0021942 0.0108458 0.010609
Schistosoma mansoni smdr2 0.00209184 0.00651306 0.00359383
Echinococcus granulosus neuropeptide FF receptor 2 0.00510222 0.133946 0.131401
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.00209184 0.00651306 0.0048023
Echinococcus multilocularis allatostatin A receptor 0.00510222 0.133946 0.131401
Onchocerca volvulus 0.00303389 0.0463907 0.137145
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.00480296 0.121278 0.118696
Onchocerca volvulus 0.00510222 0.133946 0.397701
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Brugia malayi neuropeptide F receptor 0.00510222 0.133946 0.16256
Trypanosoma cruzi cAMP response protein 1 0.00303389 0.0463907 0.130354
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.00209184 0.00651306 0.00359383
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00480296 0.121278 0.158609
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0021942 0.0108458 0.010609
Toxoplasma gondii thioredoxin reductase 0.00761339 0.240247 0.708661
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.00303389 0.0463907 0.120906
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Trichomonas vaginalis adenylate cyclase type IX, putative 0.0021942 0.0108458 0.010609
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.00510222 0.133946 0.131401
Brugia malayi ORL1-like opioid receptor 0.00510222 0.133946 0.16256
Toxoplasma gondii glutamate-cysteine ligase, catalytic subunit domain-containing protein 0.00988336 0.336337 1
Brugia malayi larval opioid receptor 0.00510222 0.133946 0.16256
Brugia malayi GnHR receptor homolog 0.00510222 0.133946 0.16256
Echinococcus multilocularis rhodopsin orphan GPCR 0.00510222 0.133946 0.131401
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.00263827 0.0296437 0.0801239
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.00209184 0.00651306 0.0048023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.00263827 0.0296437 0.0801239
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Echinococcus multilocularis neuropeptide s receptor 0.00510222 0.133946 0.131401
Brugia malayi putative neuropeptide receptor 0.00510222 0.133946 0.16256
Echinococcus granulosus neuropeptide receptor A26 0.00510222 0.133946 0.131401
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.00480296 0.121278 0.158609
Echinococcus granulosus voltage gated potassium channel 0.00699716 0.214161 0.211852
Mycobacterium tuberculosis Probable oxidoreductase 0.00263827 0.0296437 0.0255603
Trichomonas vaginalis guanylate cyclase, putative 0.0021942 0.0108458 0.010609
Echinococcus multilocularis fmrfamide receptor 0.00510222 0.133946 0.131401
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.00263827 0.0296437 0.0801239
Plasmodium falciparum cGMP-dependent protein kinase 0.00303389 0.0463907 0.130354
Brugia malayi Serotonin/octopamine receptor family protein 7 0.00510222 0.133946 0.16256
Loa Loa (eye worm) G-protein coupled receptor 0.00510222 0.133946 0.159571
Mycobacterium ulcerans hypothetical protein 0.00303389 0.0463907 0.0478367
Loa Loa (eye worm) hypothetical protein 0.00510222 0.133946 0.159571
Brugia malayi Melatonin receptor type 1A 0.00510222 0.133946 0.16256
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.00263827 0.0296437 0.5
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.00209184 0.00651306 0.0048023
Echinococcus multilocularis somatostatin receptor 0.00510222 0.133946 0.131401

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = -4.8 Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay ChEMBL. 19734910
Potency (functional) 21.1923 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors: Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493163, AID504444, AID504648] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 19734910

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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