Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0059 | 0.0162 | 0.0162 |
Brugia malayi | hypothetical protein | 0.0026 | 0.004 | 0.004 |
Trichomonas vaginalis | CAMK family protein kinase | 0.2696 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0061 | 0.0061 |
Trichomonas vaginalis | CAMK family protein kinase | 0.2696 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0019 | 0.0012 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.004 | 0.004 |
Schistosoma mansoni | cytochrome P450 | 0.0019 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.004 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 0.1041 | 0.1041 |
Trichomonas vaginalis | CAMK family protein kinase | 0.2696 | 1 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0057 | 0.0057 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0019 | 0.0012 | 0.0012 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0019 | 0.0012 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0057 | 0.0057 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0019 | 0.0012 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0015 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0019 | 0.0012 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0057 | 0.0057 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0019 | 0.0012 | 1 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0019 | 0.0012 | 0.0012 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0019 | 0.0012 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.0012 | 0.0012 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0057 | 0.0057 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0019 | 0.0012 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0057 | 0.0057 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0019 | 0.0012 | 0.0012 |
Trichomonas vaginalis | CAMK family protein kinase | 0.2696 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0028 | 0.0046 | 0.0046 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0073 | 0.0073 |
Brugia malayi | Cytochrome P450 family protein | 0.0028 | 0.0046 | 0.0046 |
Echinococcus multilocularis | 0.0019 | 0.0012 | 0.0012 | |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0177 | 0.0602 | 0.0602 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0177 | 0.0602 | 0.0602 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0019 | 0.0012 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0059 | 0.0162 | 0.0162 |
Echinococcus granulosus | Immunoglobulin | 0.0026 | 0.004 | 0.004 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0057 | 0.0057 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.0305 | 0.0305 |
Echinococcus granulosus | Serine:threonine protein kinase PLK4 | 0.1011 | 0.3715 | 0.3715 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0028 | 0.0046 | 0.0046 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0019 | 0.0012 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.2696 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0057 | 0.0057 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0057 | 0.0057 |
Echinococcus granulosus | twitchin | 0.0039 | 0.0087 | 0.0087 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.0377 | 0.0377 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0019 | 0.0012 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.2696 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0019 | 0.0012 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.2696 | 1 | 1 |
Onchocerca volvulus | 0.0295 | 0.1041 | 0.0586 | |
Brugia malayi | Fibronectin type III domain containing protein | 0.0026 | 0.004 | 0.004 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0057 | 0.0057 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0019 | 0.0012 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0073 | 0.0073 |
Brugia malayi | cytochrome P450 | 0.0019 | 0.0012 | 0.0012 |
Echinococcus multilocularis | neuroglian | 0.0029 | 0.0049 | 0.0049 |
Giardia lamblia | Kinase, PLK | 0.2696 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0295 | 0.1041 | 0.1041 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0012 | 0.0012 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0019 | 0.0012 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.2696 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0019 | 0.0012 | 0.0012 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0019 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.004 | 0.004 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0026 | 0.004 | 0.004 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0019 | 0.0012 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0019 | 0.0012 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0052 | 0.0052 |
Mycobacterium leprae | putative cytochrome p450 | 0.0019 | 0.0012 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0559 | 0.0559 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0029 | 0.0052 | 0.0052 |
Echinococcus multilocularis | Serine:threonine protein kinase PLK4 | 0.1011 | 0.3715 | 0.3715 |
Leishmania major | cytochrome p450-like protein | 0.0028 | 0.0046 | 0.0046 |
Echinococcus multilocularis | roundabout 2 | 0.0032 | 0.0061 | 0.0061 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.2696 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.0377 | 0.0377 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0019 | 0.0012 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0019 | 0.0012 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0019 | 0.0012 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0028 | 0.0046 | 0.0046 |
Schistosoma mansoni | vesicular amine transporter | 0.0026 | 0.004 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.019 | 0.019 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0019 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0061 | 0.0061 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.2696 | 1 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.0026 | 0.004 | 0.004 |
Echinococcus granulosus | neuroglian | 0.0029 | 0.0049 | 0.0049 |
Echinococcus multilocularis | Immunoglobulin | 0.0026 | 0.004 | 0.004 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0028 | 0.0046 | 0.0046 |
Echinococcus multilocularis | geminin | 0.0165 | 0.0559 | 0.0559 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0019 | 0.0012 | 0.0012 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0019 | 0.0012 | 1 |
Echinococcus granulosus | defective proboscis extension response | 0.0026 | 0.004 | 0.004 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0073 | 0.0073 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0097 | 0.0305 | 0.0305 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0028 | 0.0046 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0097 | 0.0305 | 0.0305 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0057 | 0.0057 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0028 | 0.0046 | 0.0046 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0057 | 0.0057 |
Schistosoma mansoni | nephrin | 0.0029 | 0.0049 | 0.0049 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0026 | 0.004 | 0.004 |
Trichomonas vaginalis | CAMK family protein kinase | 0.2696 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0057 | 0.0057 |
Trypanosoma brucei | polo-like protein kinase | 0.2696 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 | 0.0019 | 0.0012 | 0.0012 |
Schistosoma mansoni | cell adhesion molecule | 0.0029 | 0.0052 | 0.0052 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.2696 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0559 | 0.0559 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.0377 | 0.0377 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.004 | 0.004 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0016 | 0.0002 | 0.0002 |
Trypanosoma brucei | cytochrome P450, putative | 0.0028 | 0.0046 | 0.0046 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0097 | 0.0305 | 0.0305 |
Trichomonas vaginalis | CAMK family protein kinase | 0.2696 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.019 | 0.019 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0026 | 0.004 | 0.004 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.015 | 0.0502 | 0.0019 |
Echinococcus granulosus | geminin | 0.0165 | 0.0559 | 0.0559 |
Schistosoma mansoni | kinase | 0.2584 | 0.9581 | 0.9581 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0057 | 0.0057 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0057 | 0.0057 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0028 | 0.0046 | 0.0046 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.004 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.004 | 0.004 |
Leishmania major | cytochrome p450-like protein | 0.0019 | 0.0012 | 0.0012 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0019 | 0.0012 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0019 | 0.0012 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0066 | 0.019 | 0.019 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0026 | 0.004 | 0.004 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0073 | 0.0073 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0019 | 0.0012 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.2696 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2696 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.2696 | 1 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0032 | 0.0061 | 0.0061 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.