Detailed information for compound 1469558

Basic information

Technical information
  • TDR Targets ID: 1469558
  • Name: N-(2-methoxy-4-nitrophenyl)-2-pyridin-1-ium-1 -ylacetamide
  • MW: 288.279 | Formula: C14H14N3O4+
  • H donors: 1 H acceptors: 3 LogP: 1.79 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1NC(=O)C[n+]1ccccc1)[N+](=O)[O-]
  • InChi: 1S/C14H13N3O4/c1-21-13-9-11(17(19)20)5-6-12(13)15-14(18)10-16-7-3-2-4-8-16/h2-9H,10H2,1H3/p+1
  • InChiKey: NMJKPCLILILQQN-UHFFFAOYSA-O  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-methoxy-4-nitro-phenyl)-2-pyridin-1-ium-1-yl-acetamide
  • N-(2-methoxy-4-nitrophenyl)-2-(1-pyridin-1-iumyl)acetamide
  • N-(2-methoxy-4-nitro-phenyl)-2-pyridin-1-ium-1-yl-ethanamide
  • BAS 01248452
  • ZINC04902527

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major beta tubulin 0.0321 0.1198 0.2559
Trichomonas vaginalis conserved hypothetical protein 0.2479 1 1
Loa Loa (eye worm) animal heme peroxidase 0.0081 0.0217 0.1809
Trypanosoma brucei beta tubulin 0.0321 0.1198 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0102 0.0304 0.0099
Trichomonas vaginalis tubulin alpha chain, putative 0.018 0.0624 0.0425
Onchocerca volvulus 0.0081 0.0217 0.0337
Brugia malayi beta-tubulin, identical 0.0321 0.1198 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.012 0.0379 0.3166
Schistosoma mansoni hypothetical protein 0.0174 0.0599 0.1469
Echinococcus granulosus Tubulin beta 2C chain 0.0321 0.1198 0.5949
Loa Loa (eye worm) hypothetical protein 0.0081 0.0217 0.1809
Brugia malayi Tubulin beta chain 0.0078 0.0208 0.1732
Echinococcus granulosus tubulin alpha 3 chain 0.0258 0.0942 0.4677
Brugia malayi Tubulin alpha chain 0.0258 0.0942 0.7863
Schistosoma mansoni rab6-interacting 0.014 0.046 0.1127
Trypanosoma brucei beta tubulin 0.0321 0.1198 1
Schistosoma mansoni hypothetical protein 0.0035 0.0031 0.0076
Loa Loa (eye worm) blistered cuticle protein 3 0.0081 0.0217 0.1809
Onchocerca volvulus 0.0102 0.0304 0.0957
Loa Loa (eye worm) hypothetical protein 0.0035 0.0031 0.0259
Trypanosoma cruzi epsilon tubulin, putative 0.018 0.0624 0.4482
Echinococcus multilocularis Tubulin alpha 1 chain 0.0258 0.0942 0.4677
Echinococcus multilocularis jun protein 0.0091 0.0261 0.1295
Brugia malayi bZIP transcription factor family protein 0.0091 0.0261 0.2177
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0521 0.2014 1
Entamoeba histolytica tubulin alpha chain, putative 0.0258 0.0942 0.2231
Schistosoma mansoni jun-related protein 0.0075 0.0194 0.0475
Leishmania major alpha tubulin 0.0258 0.0942 0.1897
Echinococcus granulosus peroxidasin 0.0081 0.0217 0.1076
Leishmania major alpha tubulin 0.0258 0.0942 0.1897
Echinococcus multilocularis hypothetical protein 0.0258 0.0942 0.4677
Entamoeba histolytica tubulin alpha-1 chain 0.0258 0.0942 0.2231
Loa Loa (eye worm) tubulin alpha-3 chain 0.0156 0.0525 0.4386
Leishmania major alpha tubulin 0.0258 0.0942 0.1897
Echinococcus granulosus lipoxygenase domain containing protein 0.014 0.046 0.2283
Onchocerca volvulus Dual oxidase homolog 0.0081 0.0217 0.0337
Schistosoma mansoni polycystin 1-related 0.014 0.046 0.1127
Loa Loa (eye worm) hypothetical protein 0.0081 0.0217 0.1809
Brugia malayi Tubulin alpha-2 chain 0.0258 0.0942 0.7863
Plasmodium vivax delta tubulin, putative 0.0078 0.0208 0.0478
Echinococcus granulosus tubulin alpha 3 chain 0.0258 0.0942 0.4677
Schistosoma mansoni tubulin subunit beta 0.0321 0.1198 0.2937
Echinococcus granulosus carbonic anhydrase II 0.012 0.0379 0.1884
Trypanosoma brucei carbonic anhydrase-like protein 0.012 0.0379 0.2129
Giardia lamblia Beta tubulin 0.0321 0.1198 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.012 0.0379 0.093
Loa Loa (eye worm) hypothetical protein 0.0081 0.0217 0.1809
Onchocerca volvulus 0.0081 0.0217 0.0337
Brugia malayi tubulin alpha-2 chain 0.0258 0.0942 0.7863
Echinococcus granulosus tubulin alpha chain 0.0258 0.0942 0.4677
Schistosoma mansoni hypothetical protein 0.0174 0.0599 0.1469
Trypanosoma brucei alpha tubulin 0.0258 0.0942 0.7538
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0066 0.0158 0.1318
Plasmodium falciparum tubulin epsilon chain, putative 0.018 0.0624 0.5209
Brugia malayi hypothetical protein 0.0155 0.0522 0.4359
Leishmania major beta tubulin 0.0321 0.1198 0.2559
Schistosoma mansoni tubulin subunit beta 0.0321 0.1198 0.2937
Toxoplasma gondii beta-1 tubulin, putative 0.0321 0.1198 1
Echinococcus granulosus tubulin alpha chain 0.0258 0.0942 0.4677
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.018 0.0622 0.0424
Entamoeba histolytica tubulin gamma chain 0.018 0.0624 0.1443
Trypanosoma cruzi alpha tubulin, putative 0.0258 0.0942 0.7538
Loa Loa (eye worm) hypothetical protein 0.0081 0.0217 0.1809
Plasmodium falciparum alpha tubulin 2 0.0258 0.0942 0.7863
Echinococcus granulosus tubulin alpha 1C chain 0.0258 0.0942 0.4677
Loa Loa (eye worm) tubulin alpha 2 0.018 0.0622 0.5195
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0158 0.0388
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0083 0.0204
Leishmania major alpha tubulin 0.0258 0.0942 0.1897
Leishmania major beta tubulin 0.0321 0.1198 0.2559
Onchocerca volvulus 0.014 0.046 0.2056
Entamoeba histolytica carbonic anhydrase, putative 0.1027 0.4078 1
Echinococcus granulosus tar DNA binding protein 0.0066 0.0158 0.0785
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0083 0.0412
Leishmania major carbonic anhydrase-like protein 0.012 0.0379 0.0444
Echinococcus granulosus nuclear factor of activated T cells 5 0.0075 0.0193 0.0957
Schistosoma mansoni tubulin subunit alpha 0.0258 0.0942 0.2309
Toxoplasma gondii beta tubulin 0.0321 0.1198 1
Echinococcus granulosus RUN 0.014 0.046 0.2283
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0083 0.0412
Leishmania major alpha tubulin 0.0258 0.0942 0.1897
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.1978 0.7956 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0102 0.0304 0.0099
Trichomonas vaginalis tubulin epsilon chain, putative 0.0258 0.0942 0.075
Loa Loa (eye worm) hypothetical protein 0.0081 0.0217 0.1809
Entamoeba histolytica tubulin family protein 0.0321 0.1198 0.2865
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0217 0.1809
Echinococcus granulosus beta tubulin 0.0321 0.1198 0.5949
Chlamydia trachomatis sulfate transporter 0.0066 0.0158 0.5
Echinococcus multilocularis tubulin delta chain 0.0078 0.0208 0.1031
Echinococcus multilocularis Tubulin beta 2C chain 0.0321 0.1198 0.5949
Echinococcus granulosus beta tubulin 0.0321 0.1198 0.5949
Schistosoma mansoni rab6-interacting 0.014 0.046 0.1127
Onchocerca volvulus 0.0155 0.0522 0.2499
Trypanosoma brucei zeta tubulin 0.0078 0.0208 0.0478
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.012 0.0379 0.2129
Trichomonas vaginalis tubulin epsilon chain, putative 0.0321 0.1198 0.1011
Brugia malayi Tubulin beta chain 0.0102 0.0304 0.2541
Treponema pallidum ATP-binding protein (ylxH-1) 0.0463 0.1776 1
Brugia malayi Blistered cuticle protein 3 0.0081 0.0217 0.1809
Leishmania major beta tubulin 0.0321 0.1198 0.2559
Loa Loa (eye worm) animal heme peroxidase 0.0081 0.0217 0.1809
Schistosoma mansoni tubulin subunit gamma 0.018 0.0624 0.153
Trypanosoma brucei alpha tubulin 0.0258 0.0942 0.7538
Trichomonas vaginalis tubulin beta chain, putative 0.0258 0.0942 0.075
Echinococcus multilocularis Tubulin beta 2C chain 0.0321 0.1198 0.5949
Echinococcus multilocularis Tubulin alpha 1 chain 0.0258 0.0942 0.4677
Trichomonas vaginalis tubulin beta chain, putative 0.0258 0.0942 0.075
Leishmania major beta tubulin 0.0321 0.1198 0.2559
Trypanosoma brucei tubulin delta chain 0.0078 0.0208 0.0478
Echinococcus multilocularis tubulin alpha chain 0.0258 0.0942 0.4677
Echinococcus granulosus lipoxygenase domain containing protein 0.014 0.046 0.2283
Loa Loa (eye worm) hypothetical protein 0.0081 0.0217 0.1809
Plasmodium vivax multidomain scavenger receptor, putative 0.014 0.046 0.2902
Trichomonas vaginalis tubulin epsilon chain, putative 0.0258 0.0942 0.075
Loa Loa (eye worm) tubulin alpha chain 0.0258 0.0942 0.7863
Trichomonas vaginalis tubulin beta chain, putative 0.0102 0.0304 0.0099
Loa Loa (eye worm) animal heme peroxidase 0.0081 0.0217 0.1809
Brugia malayi MH2 domain containing protein 0.0123 0.0389 0.3247
Entamoeba histolytica tubulin family protein 0.0321 0.1198 0.2865
Echinococcus granulosus tubulin gamma 1 chain 0.018 0.0624 0.3099
Loa Loa (eye worm) tubulin alpha-2 chain 0.0258 0.0942 0.7863
Echinococcus multilocularis peroxisome assembly protein 26 0.0258 0.0942 0.4677
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.018 0.0624 0.5209
Echinococcus multilocularis tubulin subunit TubB 0.0258 0.0942 0.4677
Leishmania major alpha tubulin 0.0258 0.0942 0.1897
Echinococcus multilocularis Tubulin beta 2C chain 0.0321 0.1198 0.5949
Schistosoma mansoni tubulin subunit alpha 0.0078 0.0208 0.0509
Trichomonas vaginalis tubulin beta chain, putative 0.0321 0.1198 0.1011
Echinococcus multilocularis peroxidasin 0.0081 0.0217 0.1076
Loa Loa (eye worm) beta-tubulin 0.0321 0.1198 1
Loa Loa (eye worm) hypothetical protein 0.014 0.046 0.3837
Trypanosoma cruzi epsilon tubulin, putative 0.018 0.0624 0.4482
Brugia malayi hypothetical protein 0.014 0.046 0.3837
Trichomonas vaginalis tubulin alpha chain, putative 0.0102 0.0304 0.0099
Echinococcus granulosus tubulin beta 4A class IVa 0.0321 0.1198 0.5949
Echinococcus multilocularis Tubulin beta 2C chain 0.0321 0.1198 0.5949
Brugia malayi Tubulin alpha-2 chain 0.0258 0.0942 0.7863
Brugia malayi alpha-tubulin 0.0258 0.0942 0.7863
Echinococcus granulosus jun protein 0.0091 0.0261 0.1295
Loa Loa (eye worm) alpha-tubulin 0.0258 0.0942 0.7863
Loa Loa (eye worm) hypothetical protein 0.0081 0.0217 0.1809
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0041 0.0205
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.012 0.0379 0.093
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0091 0.0261 0.1295
Leishmania major alpha tubulin 0.0258 0.0942 0.1897
Trichomonas vaginalis tubulin gamma chain, putative 0.018 0.0624 0.0425
Echinococcus granulosus geminin 0.0174 0.0599 0.2975
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0041 0.0205
Brugia malayi Tubulin gamma chain 0.018 0.0624 0.5209
Echinococcus multilocularis tubulin alpha 3 chain 0.0258 0.0942 0.4677
Schistosoma mansoni tubulin subunit beta 0.0321 0.1198 0.2937
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0083 0.0412
Echinococcus multilocularis Tubulin alpha 1 chain 0.0258 0.0942 0.4677
Leishmania major beta tubulin 0.0321 0.1198 0.2559
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0156 0.0525 0.0325
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0389 0.3247
Leishmania major alpha tubulin 0.0258 0.0942 0.1897
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0083 0.0204
Loa Loa (eye worm) BEN-1 protein 0.0321 0.1198 1
Onchocerca volvulus Peroxidase homolog 0.0081 0.0217 0.0337
Onchocerca volvulus Putative sulfate transporter 0.0415 0.1582 1
Giardia lamblia Alpha-tubulin 0.0258 0.0942 0.7415
Leishmania major beta tubulin 0.0321 0.1198 0.2559
Echinococcus multilocularis tubulin alpha chain 0.0258 0.0942 0.4677
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0158 0.0388
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0158 0.1319
Trypanosoma cruzi tubulin gamma chain 0.018 0.0624 0.4482
Schistosoma mansoni tubulin subunit alpha 0.0258 0.0942 0.2309
Leishmania major alpha tubulin 0.0258 0.0942 0.1897
Schistosoma mansoni tubulin subunit beta 0.0321 0.1198 0.2937
Loa Loa (eye worm) hypothetical protein 0.0081 0.0217 0.1809
Trichomonas vaginalis tubulin beta chain, putative 0.0258 0.0942 0.075
Trichomonas vaginalis tubulin beta chain, putative 0.0258 0.0942 0.075
Trypanosoma cruzi zeta tubulin, putative 0.0078 0.0208 0.0478
Onchocerca volvulus Chorion peroxidase homolog 0.0081 0.0217 0.0337
Echinococcus multilocularis tubulin epsilon chain 0.018 0.0624 0.3099
Loa Loa (eye worm) hypothetical protein 0.0051 0.0097 0.0811
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0097 0.0811
Leishmania major beta tubulin 0.0321 0.1198 0.2559
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0066 0.0158 0.1318
Echinococcus granulosus tubulin alpha 0.018 0.0624 0.3099
Echinococcus multilocularis tubulin alpha chain 0.0258 0.0942 0.4677
Echinococcus granulosus Tubulin beta 2C chain 0.0321 0.1198 0.5949
Plasmodium vivax tubulin beta chain, putative 0.0321 0.1198 1
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0078 0.0208 0.5
Leishmania major gamma-tubulin 0.018 0.0624 0.1076
Schistosoma mansoni alpha tubulin 0.0258 0.0942 0.2309
Leishmania major beta tubulin 0.0321 0.1198 0.2559
Schistosoma mansoni carbonic anhydrase 0.1027 0.4078 1
Trypanosoma brucei beta tubulin 0.018 0.0624 0.4482
Echinococcus granulosus tubulin alpha chain 0.0258 0.0942 0.4677
Echinococcus multilocularis tubulin alpha 0.018 0.0624 0.3099
Mycobacterium ulcerans hypothetical protein 0.0113 0.0351 0.0196
Loa Loa (eye worm) doublecortin family protein 0.014 0.046 0.3837
Onchocerca volvulus 0.0081 0.0217 0.0337
Giardia lamblia Gamma tubulin 0.018 0.0624 0.4205
Echinococcus multilocularis tubulin subunit beta 0.0321 0.1198 0.5949
Echinococcus granulosus Tubulin beta 2C chain 0.0321 0.1198 0.5949
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0389 0.3247
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0083 0.0693
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0041 0.0101
Leishmania major beta tubulin 0.0321 0.1198 0.2559
Loa Loa (eye worm) tubulin beta chain 0.0321 0.1198 1
Echinococcus multilocularis carbonic anhydrase II 0.012 0.0379 0.1884
Trichomonas vaginalis tubulin, putative 0.0102 0.0304 0.0099
Echinococcus granulosus tubulin delta chain 0.0078 0.0208 0.1031
Echinococcus granulosus alpha tubulin 0.0258 0.0942 0.4677
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0078 0.0208 0.1732
Echinococcus granulosus Tubulin beta 2C chain 0.0321 0.1198 0.5949
Leishmania major beta tubulin 0.0321 0.1198 0.2559
Trypanosoma cruzi tubulin delta chain 0.0078 0.0208 0.0478
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0158 0.1319
Schistosoma mansoni hypothetical protein 0.0075 0.0194 0.0475
Onchocerca volvulus Peroxidasin homolog 0.0081 0.0217 0.0337
Echinococcus multilocularis RUN 0.014 0.046 0.2283
Trichomonas vaginalis tubulin gamma chain, putative 0.018 0.0624 0.0425
Trypanosoma brucei beta tubulin 0.0321 0.1198 1
Toxoplasma gondii alpha tubulin TUBA1 0.0258 0.0942 0.7863
Trichomonas vaginalis tubulin alpha chain, putative 0.0102 0.0304 0.0099
Loa Loa (eye worm) tubulin beta-4 chain 0.0321 0.1198 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0258 0.0942 0.4677
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0981 0.3888 0.4751
Schistosoma mansoni tubulin subunit beta 0.0321 0.1198 0.2937
Loa Loa (eye worm) hypothetical protein 0.0081 0.0217 0.1809
Echinococcus multilocularis Polycystic kidney disease protein 0.014 0.046 0.2283
Trichomonas vaginalis tubulin alpha chain, putative 0.0321 0.1198 0.1011
Brugia malayi tubulin alpha chain - mouse 0.0258 0.0942 0.7863
Loa Loa (eye worm) hypothetical protein 0.0258 0.0942 0.7863
Trypanosoma brucei epsilon tubulin 0.018 0.0624 0.4482
Loa Loa (eye worm) hypothetical protein 0.0081 0.0217 0.1809
Brugia malayi hypothetical protein 0.014 0.046 0.3837
Brugia malayi Tubulin alpha chain 0.0078 0.0208 0.1732
Brugia malayi hypothetical protein 0.0069 0.0169 0.1412
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0158 0.0388
Schistosoma mansoni tubulin subunit beta 0.0078 0.0208 0.0509
Onchocerca volvulus Peroxidasin homolog 0.0081 0.0217 0.0337
Trypanosoma cruzi tubulin delta chain 0.0078 0.0208 0.0478
Echinococcus granulosus tubulin subunit beta 0.0321 0.1198 0.5949
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0097 0.0811
Echinococcus multilocularis geminin 0.0174 0.0599 0.2975
Loa Loa (eye worm) carbonic anhydrase 3 0.012 0.0379 0.3166
Brugia malayi Peroxidasin 0.0081 0.0217 0.1809
Leishmania major alpha tubulin 0.0258 0.0942 0.1897
Trypanosoma brucei epsilon tubulin 0.018 0.0624 0.4482
Trichomonas vaginalis tubulin epsilon chain, putative 0.0321 0.1198 0.1011
Trypanosoma cruzi zeta tubulin, putative 0.0078 0.0208 0.0478
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.1027 0.4078 1
Echinococcus granulosus Tubulin beta 2C chain 0.0321 0.1198 0.5949
Plasmodium vivax tubulin alpha chain, putative 0.0258 0.0942 0.7538
Trichomonas vaginalis tubulin gamma chain, putative 0.0321 0.1198 0.1011
Onchocerca volvulus 0.014 0.046 0.2056
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0217 0.1809
Trypanosoma brucei beta tubulin 0.0321 0.1198 1
Loa Loa (eye worm) tubulin beta-1 chain 0.0321 0.1198 1
Toxoplasma gondii beta-tubulin, putative 0.0321 0.1198 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0521 0.2014 1
Loa Loa (eye worm) BEN-1 protein 0.0321 0.1198 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0075 0.0193 0.0957
Leishmania major beta tubulin 0.0321 0.1198 0.2559
Brugia malayi RNA binding protein 0.0066 0.0158 0.1319
Trichomonas vaginalis conserved hypothetical protein 0.2479 1 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0321 0.1198 0.5949
Plasmodium falciparum tubulin beta chain 0.0321 0.1198 1
Trichomonas vaginalis tubulin, putative 0.0102 0.0304 0.0099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0083 0.0204
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0217 0.1809
Leishmania major alpha tubulin 0.0258 0.0942 0.1897
Plasmodium falciparum alpha tubulin 1 0.0258 0.0942 0.7863
Schistosoma mansoni peroxidasin 0.0081 0.0217 0.0531
Echinococcus granulosus tubulin subunit TubB 0.0258 0.0942 0.4677
Loa Loa (eye worm) hypothetical protein 0.018 0.0622 0.5195
Schistosoma mansoni tubulin subunit delta 0.0078 0.0208 0.0509
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.048 0.1845 0.2113
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0258 0.0942 0.075
Echinococcus multilocularis tubulin alpha chain 0.0258 0.0942 0.4677
Leishmania major beta tubulin 0.0321 0.1198 0.2559
Brugia malayi Putative carbonic anhydrase 5 precursor 0.012 0.0379 0.3166
Schistosoma mansoni tubulin subunit alpha 0.0258 0.0942 0.2309
Echinococcus granulosus tubulin alpha chain 0.0258 0.0942 0.4677
Leishmania major beta tubulin 0.0321 0.1198 0.2559
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.012 0.0379 0.2129
Mycobacterium ulcerans carbonic anhydrase 0.1027 0.4078 0.3983
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0217 0.1809
Echinococcus granulosus peroxisome assembly protein 26 0.0258 0.0942 0.4677
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0097 0.0811
Schistosoma mansoni tubulin subunit epsilon 0.018 0.0624 0.153
Trypanosoma brucei zeta tubulin, putative 0.0078 0.0208 0.0478
Echinococcus granulosus Polycystic kidney disease protein 0.014 0.046 0.2283
Echinococcus granulosus Tubulin alpha 1 chain 0.0258 0.0942 0.4677
Echinococcus granulosus tubulin alpha 1C chain 0.0258 0.0942 0.4677
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.012 0.0379 0.3166
Loa Loa (eye worm) hypothetical protein 0.0081 0.0217 0.1809
Brugia malayi Tubulin beta-1 chain 0.0321 0.1198 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0078 0.0208 0.1732
Trypanosoma brucei tubulin gamma chain 0.018 0.0624 0.4482
Leishmania major beta tubulin 0.0321 0.1198 0.2559
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0083 0.0693
Schistosoma mansoni alpha tubulin 0.0258 0.0942 0.2309
Onchocerca volvulus 0.0415 0.1582 1
Leishmania major epsilon tubulin, putative 0.018 0.0624 0.1076
Loa Loa (eye worm) hypothetical protein 0.0081 0.0217 0.1809
Plasmodium falciparum tubulin gamma chain 0.018 0.0624 0.5209
Trypanosoma brucei alpha tubulin, putative 0.0102 0.0304 0.1409
Brugia malayi hypothetical protein 0.0081 0.0217 0.1809
Loa Loa (eye worm) tubulin beta-2A chain 0.0321 0.1198 1
Plasmodium falciparum tubulin delta chain, putative 0.0078 0.0208 0.1732
Echinococcus multilocularis Tubulin beta 2C chain 0.0321 0.1198 0.5949
Schistosoma mansoni alpha tubulin 0.0258 0.0942 0.2309
Trichomonas vaginalis tubulin, putative 0.0321 0.1198 0.1011
Schistosoma mansoni lipoxygenase 0.0521 0.2014 0.4937
Loa Loa (eye worm) alpha-tubulin 0.0258 0.0942 0.7863
Trypanosoma brucei epsilon tubulin 0.018 0.0624 0.4482
Plasmodium vivax tubulin gamma chain, putative 0.018 0.0624 0.4482
Plasmodium vivax tubulin alpha chain, putative 0.0258 0.0942 0.7538
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0158 0.0388
Loa Loa (eye worm) tubulin gamma chain 0.018 0.0624 0.5209
Brugia malayi hypothetical protein 0.0038 0.0041 0.0345
Onchocerca volvulus Peroxidase homolog 0.0081 0.0217 0.0337
Echinococcus multilocularis tubulin alpha 1C chain 0.0258 0.0942 0.4677
Echinococcus multilocularis tubulin alpha 3 chain 0.0258 0.0942 0.4677
Echinococcus granulosus tubulin alpha chain 0.0258 0.0942 0.4677
Echinococcus multilocularis tubulin alpha chain 0.0258 0.0942 0.4677
Schistosoma mansoni lipoxygenase 0.0269 0.0985 0.2414
Loa Loa (eye worm) tubulin alpha chain 0.0258 0.0942 0.7863
Loa Loa (eye worm) hypothetical protein 0.0155 0.0522 0.4359
Brugia malayi TAR-binding protein 0.0066 0.0158 0.1319
Loa Loa (eye worm) tubulin beta chain 0.0078 0.0208 0.1732
Brugia malayi Animal haem peroxidase family protein 0.0081 0.0217 0.1809
Echinococcus multilocularis tubulin alpha 1C chain 0.0258 0.0942 0.4677
Loa Loa (eye worm) alpha-tubulin isotype 2 0.018 0.0622 0.5195
Schistosoma mansoni peroxidasin 0.0081 0.0217 0.0531
Plasmodium vivax tubulin epsilon chain, putative 0.018 0.0624 0.4482
Giardia lamblia Beta tubulin 0.0321 0.1198 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0091 0.0261 0.1295
Giardia lamblia Alpha-tubulin 0.0258 0.0942 0.7415
Trypanosoma brucei alpha tubulin 0.0258 0.0942 0.7538
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0031 0.0259
Schistosoma mansoni tubulin subunit beta 0.0321 0.1198 0.2937
Leishmania major beta tubulin 0.0321 0.1198 0.2559
Echinococcus granulosus Tubulin alpha 1 chain 0.0258 0.0942 0.4677
Trichomonas vaginalis tubulin beta chain, putative 0.0258 0.0942 0.075
Brugia malayi Cell division protein ftsZ 0.0078 0.0208 0.1732
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0083 0.0412
Loa Loa (eye worm) hypothetical protein 0.0085 0.0236 0.1972
Leishmania major carbonic anhydrase family protein, putative 0.1027 0.4078 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.0525 0.4386
Echinococcus granulosus tubulin beta 1 chain 0.0321 0.1198 0.5949
Mycobacterium leprae Probable transmembrane transport protein 0.048 0.1845 0.4229
Trichomonas vaginalis tubulin beta chain, putative 0.0258 0.0942 0.075
Loa Loa (eye worm) hypothetical protein 0.0081 0.0217 0.1809
Echinococcus multilocularis beta tubulin 0.0321 0.1198 0.5949
Echinococcus multilocularis tubulin beta 1 chain 0.0321 0.1198 0.5949
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0526 0.2034 0.2357
Schistosoma mansoni hypothetical protein 0.014 0.046 0.1127
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0158 0.0388
Trypanosoma brucei alpha tubulin 0.0258 0.0942 0.7538
Brugia malayi Doublecortin family protein 0.014 0.046 0.3837
Loa Loa (eye worm) animal heme peroxidase 0.0081 0.0217 0.1809
Loa Loa (eye worm) RNA binding protein 0.0066 0.0158 0.1319
Leishmania major beta tubulin 0.0321 0.1198 0.2559
Loa Loa (eye worm) hypothetical protein 0.014 0.046 0.3837
Toxoplasma gondii alpha-tubulin I, putative 0.0258 0.0942 0.7863
Leishmania major beta tubulin 0.0321 0.1198 0.2559
Echinococcus granulosus tubulin epsilon chain 0.018 0.0624 0.3099
Loa Loa (eye worm) tubulin alpha 2 0.018 0.0622 0.5195
Leishmania major alpha tubulin 0.0258 0.0942 0.1897
Echinococcus multilocularis lipoxygenase domain containing protein 0.014 0.046 0.2283
Mycobacterium ulcerans cell division protein FtsZ 0.0078 0.0208 0.005
Giardia lamblia Beta tubulin 0.0321 0.1198 1
Plasmodium falciparum LCCL domain-containing protein 0.014 0.046 0.3837
Echinococcus multilocularis lipoxygenase domain containing protein 0.014 0.046 0.2283
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0158 0.1319
Schistosoma mansoni hypothetical protein 0.0038 0.0041 0.0101
Schistosoma mansoni loxhd1 0.014 0.046 0.1127
Loa Loa (eye worm) tubulin alpha 2 0.0078 0.0206 0.1719
Echinococcus multilocularis tubulin gamma 1 chain 0.018 0.0624 0.3099
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0158 0.0785
Loa Loa (eye worm) hypothetical protein 0.0081 0.0217 0.1809
Echinococcus multilocularis beta tubulin 0.0321 0.1198 0.5949
Trypanosoma cruzi beta tubulin, putative 0.0321 0.1198 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.