Detailed information for compound 147870

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 353.46 | Formula: C24H23N3
  • H donors: 1 H acceptors: 1 LogP: 5.39 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CCN(C1)Cc1ccc(cc1)Nc1c2ccccc2nc2c1cccc2
  • InChi: 1S/C24H23N3/c1-3-9-22-20(7-1)24(21-8-2-4-10-23(21)26-22)25-19-13-11-18(12-14-19)17-27-15-5-6-16-27/h1-4,7-14H,5-6,15-17H2,(H,25,26)
  • InChiKey: QPIPWQDMZKDMIG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0129761 0.5 0.5
Schistosoma mansoni hypothetical protein 0.0023 0.0237 0.021
Echinococcus multilocularis FTZ F1 alpha 0.013 0.2191 0.2169
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0026 0.0288 0.8003
Echinococcus multilocularis chromobox protein 1 0.0056 0.0835 0.0811
Brugia malayi Steroid receptor seven-up type 2 0.013 0.2191 0.5129
Brugia malayi nuclear hormone receptor 0.0129761 0.5 0.5
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0061 0.0931 0.0906
Brugia malayi hypothetical protein 0.0069 0.1066 0.2496
Echinococcus multilocularis GPCR, family 2 0.0013 0.0039 0.0012
Loa Loa (eye worm) heterochromatin protein 1 0.0056 0.0835 0.1905
Echinococcus granulosus methyl CpG binding domain protein 2 0.0014 0.0058 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0129761 0.5 0.5
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0077 0.1217 0.1193
Loa Loa (eye worm) hypothetical protein 0.0069 0.1066 0.2448
Schistosoma mansoni hypothetical protein 0.0017 0.0111 0.0084
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0027 0.0299 0.0642
Echinococcus granulosus PHD finger protein rhinoceros 0.0023 0.0237 0.021
Loa Loa (eye worm) hypothetical protein 0.013 0.2191 0.5099
Loa Loa (eye worm) hypothetical protein 0.0031 0.0373 0.0815
Echinococcus granulosus ecdysone induced protein 78C 0.0129761 0.5 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0129761 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.013 0.2191 0.5099
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0019 0.0163 0.0137
Schistosoma mansoni rotamase 0.0027 0.0299 0.0273
Brugia malayi hypothetical protein 0.0029 0.0338 0.079
Loa Loa (eye worm) steroid hormone receptor 0.013 0.2191 0.5099
Loa Loa (eye worm) hypothetical protein 0.0243 0.427 1
Brugia malayi nuclear hormone receptor 0.013 0.2191 0.5129
Loa Loa (eye worm) hypothetical protein 0.0129761 0.5 0.5
Brugia malayi Pre-SET motif family protein 0.0168 0.289 0.6767
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0129761 0.5 0.5
Echinococcus multilocularis thyroid hormone receptor alpha 0.013 0.2191 0.2169
Onchocerca volvulus Protein ultraspiracle homolog 0.013 0.2191 0.4852
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0071 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0026 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0129761 0.5 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0069 0.1066 0.2496
Loa Loa (eye worm) hypothetical protein 0.0033 0.0408 0.0898
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0129761 0.5 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.004 0.0542 0.127
Loa Loa (eye worm) DR-78 0.0061 0.0931 0.213
Brugia malayi Nuclear hormone receptor E75 0.0061 0.0931 0.218
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0129761 0.5 0.5
Trichomonas vaginalis inositol monophosphatase, putative 0.003 0.0352 0.1009
Brugia malayi steroid hormone receptor 0.0129761 0.5 0.5
Brugia malayi ecdysteroid receptor 0.013 0.2191 0.5129
Toxoplasma gondii histone lysine methyltransferase SET1 0.0047 0.0661 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.1066 0.2448
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.013 0.2191 0.2169
Loa Loa (eye worm) transcription factor SMAD2 0.0096 0.157 0.3635
Onchocerca volvulus 0.013 0.2191 0.4852
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0129761 0.5 0.5
Schistosoma mansoni nuclear hormone receptor 0.013 0.2191 0.2169
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.013 0.2191 0.5099
Brugia malayi Nuclear hormone receptor family member nhr-41 0.013 0.2191 0.5129
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0029 0.0337 0.0311
Trichomonas vaginalis chromobox protein, putative 0.0056 0.0835 0.2477
Schistosoma mansoni cpg binding protein 0.0026 0.0283 0.0256
Schistosoma mansoni chromobox protein 0.0056 0.0835 0.0811
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0129761 0.5 0.5
Loa Loa (eye worm) CXXC zinc finger family protein 0.0023 0.023 0.0479
Schistosoma mansoni bromodomain containing protein 0.0052 0.0765 0.074
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0129761 0.5 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.013 0.2191 0.2169
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.003 0.0352 1
Loa Loa (eye worm) hypothetical protein 0.0129761 0.5 0.5
Schistosoma mansoni hypothetical protein 0.0013 0.0039 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.013 0.2191 0.5129
Echinococcus multilocularis jumonji domain containing protein 0.0033 0.0405 0.038
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.013 0.2191 0.2169
Entamoeba histolytica hypothetical protein 0.0029 0.0338 0.7783
Schistosoma mansoni retinoic acid receptor RXR 0.0129761 0.5 0.5
Brugia malayi ecdysteroid receptor 0.0129761 0.5 0.5
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0023 0.0231 0.0204
Schistosoma mansoni methyl-cpg binding protein mbd 0.0014 0.0058 0.0031
Echinococcus granulosus GPCR family 2 0.0013 0.0039 0.0012
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0013 0.0039 0.0012
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0026 0.0288 0.8003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0061 0.0931 0.0906
Trichomonas vaginalis myo inositol monophosphatase, putative 0.003 0.0352 0.1009
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0069 0.1066 0.1042
Echinococcus granulosus lysine specific demethylase 5A 0.0031 0.038 0.0354
Onchocerca volvulus 0.0129761 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0237 0.0494
Echinococcus granulosus inositol monophosphatase 1 0.003 0.0352 0.0326
Loa Loa (eye worm) hypothetical protein 0.013 0.2191 0.5099
Brugia malayi nuclear hormone receptor 0.0061 0.0931 0.218
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0019 0.0163 0.0137
Echinococcus granulosus cpg binding protein 0.0026 0.0283 0.0256
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0129761 0.5 0.5
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0071 0.0157
Echinococcus multilocularis chromobox protein 1 0.0056 0.0835 0.0811
Schistosoma mansoni cpg binding protein 0.0023 0.023 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-19 0.013 0.2191 0.5129
Echinococcus granulosus Nuclear hormone receptor HR96 0.0061 0.0931 0.0906
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0129761 0.5 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.013 0.2191 0.5099
Loa Loa (eye worm) hypothetical protein 0.0061 0.0931 0.213
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0299 0.0851
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0071 0.0157
Echinococcus multilocularis lysine specific demethylase 5A 0.0028 0.0327 0.0301
Brugia malayi photoreceptor-specific nuclear receptor 0.0129761 0.5 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0129761 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0129761 0.5 0.5
Entamoeba histolytica hypothetical protein 0.0029 0.0338 0.7783
Schistosoma mansoni nuclear hormone receptor 0.0129761 0.5 0.5
Brugia malayi nuclear receptor NHR-88 0.013 0.2191 0.5129
Brugia malayi PHD-finger family protein 0.0021 0.0198 0.0464
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.013 0.2191 0.2169
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0129761 0.5 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.0061 0.0931 0.0906
Schistosoma mansoni zinc finger protein 0.0012 0.0032 0.0005
Echinococcus granulosus expressed protein 0.0027 0.0299 0.0273
Echinococcus granulosus neuropeptide receptor A26 0.0372 0.6637 0.6628
Loa Loa (eye worm) hypothetical protein 0.0038 0.0508 0.1134
Brugia malayi Inositol-1 0.003 0.0352 0.0824
Echinococcus granulosus retinoic acid receptor rxr beta a 0.013 0.2191 0.2169
Brugia malayi tailless protein 0.0061 0.0931 0.218
Brugia malayi Nuclear hormone receptor E75 0.0061 0.0931 0.218
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0029 0.0338 0.0311
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0427 0.1237
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0013 0.0039 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0071 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-49 0.013 0.2191 0.5129
Loa Loa (eye worm) pigment dispersing factor receptor c 0.004 0.0542 0.1215
Brugia malayi Nuclear hormone receptor family member nhr-40 0.013 0.2191 0.5129
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0129761 0.5 0.5
Schistosoma mansoni thyroid hormone receptor 0.0129761 0.5 0.5
Echinococcus multilocularis peregrin 0.0025 0.0272 0.0245
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.013 0.2191 0.5129
Loa Loa (eye worm) latrophilin receptor protein 2 0.0013 0.0039 0.0029
Echinococcus granulosus nuclear receptor 2DBD gamma 0.013 0.2191 0.2169
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0129761 0.5 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.0129761 0.5 0.5
Loa Loa (eye worm) bromodomain containing protein 0.0014 0.0067 0.0095
Onchocerca volvulus 0.0061 0.0931 0.1734
Brugia malayi hypothetical protein 0.0243 0.427 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0851 0.1941
Schistosoma mansoni retinoic acid receptor RXR 0.013 0.2191 0.2169
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.013 0.2191 0.2169
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0129761 0.5 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0215 0.0593
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.003 0.0352 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0025 0.0256 0.0461
Loa Loa (eye worm) steroid hormone receptor 0.0129761 0.5 0.5
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.013 0.2191 0.2169
Schistosoma mansoni steroid hormone receptor ad4bp 0.013 0.2191 0.2169
Entamoeba histolytica hypothetical protein 0.0029 0.0338 0.7783
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0129761 0.5 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0027 0.0309 0.0725
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0061 0.0931 0.1734
Loa Loa (eye worm) hypothetical protein 0.0129761 0.5 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0129761 0.5 0.5
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0027 0.0299 0.0701
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0027 0.0294 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0129761 0.5 0.5
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.013 0.2191 0.2169
Trichomonas vaginalis chromobox protein, putative 0.0056 0.0835 0.2477
Echinococcus multilocularis ecdysone induced protein 78C 0.013 0.2191 0.2169
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0071 0.0157
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0026 0.0021
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0061 0.0931 0.0906
Schistosoma mansoni thyroid hormone receptor 0.013 0.2191 0.2169
Loa Loa (eye worm) hypothetical protein 0.0069 0.1066 0.2448
Loa Loa (eye worm) hypothetical protein 0.0061 0.0931 0.213
Brugia malayi Nuclear hormone receptor-like 1 0.0129761 0.5 0.5
Brugia malayi Steroid receptor seven-up type 2 0.0129761 0.5 0.5
Echinococcus granulosus histone lysine methyltransferase setb 0.0038 0.0508 0.0483
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0215 0.0593
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0129761 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0544 0.1219
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.013 0.2191 0.2169
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0129761 0.5 0.5
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0026 0.0288 0.8003
Echinococcus multilocularis microtubule associated protein 2 0.0555 1 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0061 0.0931 0.218
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0031 0.0383 0.0378
Loa Loa (eye worm) hypothetical protein 0.0061 0.0931 0.213
Schistosoma mansoni nuclear hormone receptor 0.0061 0.0931 0.0906
Loa Loa (eye worm) hypothetical protein 0.0061 0.0931 0.213
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0013 0.0039 0.0012
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0129761 0.5 0.5
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0168 0.289 0.6746
Brugia malayi ecdysone receptor 0.0061 0.0931 0.218
Brugia malayi photoreceptor-specific nuclear receptor 0.013 0.2191 0.5129
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0061 0.0931 0.218
Trichomonas vaginalis chromobox protein, putative 0.0034 0.0427 0.1237
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0034 0.0427 0.0486
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0129761 0.5 0.5
Echinococcus multilocularis cpg binding protein 0.0026 0.0283 0.0256
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.013 0.2191 0.2169
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0049 0.0712 0.0687
Onchocerca volvulus 0.0025 0.0258 0.0069
Loa Loa (eye worm) hypothetical protein 0.0061 0.0931 0.213
Loa Loa (eye worm) hypothetical protein 0.0061 0.0931 0.213
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.013 0.2191 0.2169
Loa Loa (eye worm) hypothetical protein 0.0061 0.0931 0.213
Loa Loa (eye worm) hypothetical protein 0.0129761 0.5 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0129761 0.5 0.5
Entamoeba histolytica hypothetical protein 0.0029 0.0338 0.7783
Brugia malayi Bromodomain containing protein 0.0025 0.0272 0.0636
Schistosoma mansoni RAR-like nuclear receptor 0.013 0.2191 0.2169
Schistosoma mansoni hypothetical protein 0.0029 0.0338 0.0311
Loa Loa (eye worm) hypothetical protein 0.0061 0.0931 0.213
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0129761 0.5 0.5
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.013 0.2191 0.4852
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0071 0.0157
Schistosoma mansoni nuclear hormone receptor 0.0061 0.0931 0.0906
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.003 0.0352 0.5
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0061 0.0931 0.0906
Schistosoma mansoni nuclear receptor nhr-48 0.0061 0.0931 0.0906
Loa Loa (eye worm) hypothetical protein 0.0025 0.0258 0.0545
Loa Loa (eye worm) hypothetical protein 0.0061 0.0931 0.213
Schistosoma mansoni coup transcription factor 0.013 0.2191 0.2169
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0061 0.0931 0.0906
Echinococcus granulosus FTZ F1 alpha 0.0129761 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.0309 0.0666
Schistosoma mansoni hypothetical protein 0.0329 0.5848 0.5837
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0129761 0.5 0.5
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0025 0.0256 0.023
Echinococcus granulosus FTZ F1 alpha 0.013 0.2191 0.2169
Schistosoma mansoni Tr4/Tr2 (homologue) 0.013 0.2191 0.2169
Brugia malayi nuclear receptor NHR-67 0.0061 0.0931 0.218
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0014 0.0058 0.0031
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0068 0.0042
Loa Loa (eye worm) hypothetical protein 0.0061 0.0931 0.213
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0077 0.1217 0.1193
Loa Loa (eye worm) nuclear hormone receptor 0.0061 0.0931 0.213
Brugia malayi Nuclear hormone receptor-like 1 0.013 0.2191 0.5129
Brugia malayi jmjC domain containing protein 0.0031 0.038 0.0889
Loa Loa (eye worm) hypothetical protein 0.013 0.2191 0.5099
Onchocerca volvulus 0.0243 0.427 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.013 0.2191 0.2169
Loa Loa (eye worm) MH2 domain-containing protein 0.0096 0.157 0.3635
Loa Loa (eye worm) jmjC domain-containing protein 0.0048 0.0695 0.1575
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.013 0.2191 0.5099
Brugia malayi CHD4 protein 0.0012 0.0027 0.0063
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.003 0.0352 1
Schistosoma mansoni thyroid hormone receptor 0.0129761 0.5 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0508 0.0483
Schistosoma mansoni zinc finger protein 0.0017 0.0119 0.0093
Echinococcus multilocularis expressed protein 0.0027 0.0299 0.0273
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0129761 0.5 0.5
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0237 0.0494
Brugia malayi hypothetical protein 0.0061 0.0931 0.218
Brugia malayi chromobox protein homolog 3 0.0031 0.0383 0.0897
Brugia malayi Nuclear hormone receptor family member nhr-1 0.013 0.2191 0.5129
Trichomonas vaginalis rotamase, putative 0.0026 0.0288 0.0816
Loa Loa (eye worm) hypothetical protein 0.0129761 0.5 0.5
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0061 0.0931 0.0906
Echinococcus multilocularis FTZ F1 alpha 0.0129761 0.5 0.5
Plasmodium vivax SET domain protein, putative 0.0025 0.0256 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0061 0.0931 0.1734
Loa Loa (eye worm) hypothetical protein 0.0061 0.0931 0.213
Loa Loa (eye worm) hypothetical protein 0.0061 0.0931 0.213
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0129761 0.5 0.5
Brugia malayi CXXC zinc finger family protein 0.0023 0.023 0.0539
Schistosoma mansoni hypothetical protein 0.0013 0.0039 0.0012
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0029 0.0338 0.0311
Schistosoma mansoni chromobox protein 0.0056 0.0835 0.0811
Onchocerca volvulus Bile acid receptor homolog 0.0129761 0.5 0.5
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0069 0.1066 0.1042
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0023 0.0237 0.021
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0129761 0.5 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0031 0.038 0.0354
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.003 0.0352 0.5
Loa Loa (eye worm) hypothetical protein 0.004 0.0542 0.1215
Brugia malayi Latrophilin receptor protein 2 0.0013 0.0039 0.0091
Giardia lamblia PHD finger protein 15 0.0023 0.0237 0.5
Echinococcus multilocularis PHD finger protein rhinoceros 0.0023 0.0237 0.021
Brugia malayi Heterochromatin protein 1 0.0056 0.0835 0.1956
Onchocerca volvulus Alhambra homolog 0.0023 0.0237 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0129761 0.5 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.013 0.2191 0.5129
Brugia malayi Nuclear hormone receptor-like 1 0.0069 0.1066 0.2496
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.013 0.2191 0.5099
Schistosoma mansoni microtubule-associated protein tau 0.0555 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0013 0.0039 0.0091
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0425 0.0399
Loa Loa (eye worm) hypothetical protein 0.013 0.2191 0.5099
Loa Loa (eye worm) hypothetical protein 0.0129761 0.5 0.5
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0061 0.0931 0.0906
Echinococcus multilocularis ecdysone induced protein 78C 0.0129761 0.5 0.5
Schistosoma mansoni methyl-cpg binding protein mbd 0.0014 0.0058 0.0031
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0129761 0.5 0.5
Brugia malayi Bromodomain containing protein 0.0031 0.0372 0.0871
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.003 0.0352 1
Brugia malayi orphan nuclear receptor NR2E1 0.0061 0.0931 0.218
Loa Loa (eye worm) hypothetical protein 0.013 0.2191 0.5099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0129761 0.5 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.013 0.2191 0.2169
Toxoplasma gondii peptidylprolyl isomerase 0.0026 0.0288 0.1205
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0026 0.0288 0.8003
Echinococcus multilocularis neuropeptide receptor A26 0.0372 0.6637 0.6628
Brugia malayi nuclear hormone receptor family member nhr-6 0.0061 0.0931 0.218
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0025 0.0256 0.023
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0069 0.1066 0.2448
Trichomonas vaginalis myo inositol monophosphatase, putative 0.003 0.0352 0.1009
Brugia malayi nuclear receptor RXR 0.0069 0.1066 0.2496
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0071 0.0157
Trichomonas vaginalis rotamase, putative 0.0027 0.0299 0.0851
Echinococcus multilocularis neuropeptide s receptor 0.0372 0.6637 0.6628
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.038 0.0831
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0027 0.0294 0.5
Brugia malayi PHD-finger family protein 0.0023 0.0237 0.0554
Brugia malayi conserved hypotetical protein 0.0061 0.0931 0.218
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0013 0.0039 0.0012
Schistosoma mansoni cpg binding protein 0.0026 0.0283 0.0256
Schistosoma mansoni hypothetical protein 0.0013 0.0039 0.0012
Schistosoma mansoni hypothetical protein 0.0012 0.0032 0.0005
Schistosoma mansoni steroid hormone receptor ad4bp 0.0129761 0.5 0.5
Entamoeba histolytica myo-inositol monophosphatase, putative 0.003 0.0352 1
Echinococcus multilocularis dnaJ subfamily B 0.0329 0.5848 0.5837
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.013 0.2191 0.2169
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0029 0.0337 0.0311
Schistosoma mansoni hypothetical protein 0.0013 0.0039 0.0012
Loa Loa (eye worm) inositol-1 0.003 0.0352 0.0765
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0129761 0.5 0.5
Echinococcus granulosus peregrin 0.0025 0.0272 0.0245
Echinococcus granulosus jumonji domain containing protein 0.0033 0.0405 0.038
Brugia malayi MH2 domain containing protein 0.0096 0.157 0.3676
Echinococcus granulosus dnaJ subfamily B 0.0329 0.5848 0.5837
Onchocerca volvulus Bile acid receptor homolog 0.013 0.2191 0.4852
Echinococcus multilocularis nuclear receptor nhr 48 0.0061 0.0931 0.0906
Brugia malayi steroid hormone receptor 0.013 0.2191 0.5129
Schistosoma mansoni inositol monophosphatase 0.003 0.0352 0.0326
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0129761 0.5 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.013 0.2191 0.5099
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0029
Loa Loa (eye worm) hypothetical protein 0.0069 0.1066 0.2448
Brugia malayi nuclear receptor NHR-88 0.0061 0.0931 0.218
Brugia malayi hypothetical protein 0.0061 0.0931 0.218
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.013 0.2191 0.2169
Onchocerca volvulus 0.0191 0.3314 0.7634
Echinococcus granulosus nuclear receptor nhr 48 0.0061 0.0931 0.0906
Echinococcus multilocularis inositol monophosphatase 1 0.003 0.0352 0.0326
Schistosoma mansoni thyroid hormone receptor 0.013 0.2191 0.2169
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.013 0.2191 0.5099
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0038 0.0508 0.0483
Brugia malayi Nuclear hormone receptor family member nhr-14 0.013 0.2191 0.5129
Brugia malayi nuclear receptor RXR 0.0061 0.0931 0.218
Plasmodium falciparum phd finger protein, putative 0.0023 0.0237 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.013 0.2191 0.2169
Loa Loa (eye worm) nuclear receptor NHR-67 0.0061 0.0931 0.213
Echinococcus granulosus fetal alzheimer antigen falz 0.0019 0.0163 0.0137
Loa Loa (eye worm) hypothetical protein 0.0069 0.1066 0.2448
Schistosoma mansoni jumonji/arid domain-containing protein 0.0031 0.038 0.0354
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0061 0.0931 0.0906
Schistosoma mansoni zinc finger protein 0.0061 0.0931 0.0906
Brugia malayi Nuclear hormone receptor family member nhr-31 0.013 0.2191 0.5129
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0061 0.0931 0.213
Loa Loa (eye worm) hypothetical protein 0.0061 0.0931 0.213
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0927 0.0902
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0129761 0.5 0.5
Echinococcus granulosus neuropeptide s receptor 0.0372 0.6637 0.6628
Echinococcus multilocularis thyroid hormone receptor alpha 0.0129761 0.5 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.004 0.0542 0.127
Loa Loa (eye worm) PHD-finger family protein 0.0017 0.0111 0.0198
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.013 0.2191 0.5129
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0508 0.0483
Loa Loa (eye worm) hypothetical protein 0.0036 0.046 0.1021
Loa Loa (eye worm) hypothetical protein 0.0031 0.0383 0.0839
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.013 0.2191 0.2169
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0121 0.0283
Loa Loa (eye worm) hypothetical protein 0.013 0.2191 0.5099
Schistosoma mansoni coup transcription factor 0.0129761 0.5 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0129761 0.5 0.5
Echinococcus granulosus thyroid hormone receptor alpha 0.0061 0.0931 0.0906
Brugia malayi jmjC domain containing protein 0.0077 0.1217 0.2849
Echinococcus granulosus chromobox protein 1 0.0056 0.0835 0.0811
Brugia malayi Bromodomain containing protein 0.0062 0.0938 0.2197
Brugia malayi Nuclear hormone receptor family member nhr-3 0.013 0.2191 0.5129
Loa Loa (eye worm) hypothetical protein 0.013 0.2191 0.5099
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0069 0.1066 0.1042
Echinococcus multilocularis zinc finger protein 0.0017 0.0119 0.0093
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.003 0.0352 0.2709
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0071 0.0157
Onchocerca volvulus 0.0034 0.0425 0.0481
Echinococcus granulosus zinc finger protein 0.0017 0.0119 0.0093
Brugia malayi hypothetical protein 0.0069 0.1066 0.2496
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.013 0.2191 0.5099
Brugia malayi Nuclear hormone receptor family member nhr-25 0.013 0.2191 0.5129
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0061 0.0931 0.0906
Echinococcus granulosus chromobox protein 1 0.0056 0.0835 0.0811
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0129761 0.5 0.5
Brugia malayi nuclear receptor NHR-88 0.0129761 0.5 0.5
Trichomonas vaginalis set domain proteins, putative 0.0191 0.3314 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0129761 0.5 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0129761 0.5 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0129761 0.5 0.5
Onchocerca volvulus 0.0061 0.0931 0.1734
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0049 0.0712 0.0687
Schistosoma mansoni hypothetical protein 0.0027 0.0309 0.0283
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0383 0.1104
Schistosoma mansoni mixed-lineage leukemia protein mll 0.005 0.0722 0.0697
Brugia malayi Pre-SET motif family protein 0.0025 0.0256 0.06
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0383 0.1104
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.013 0.2191 0.2169
Schistosoma mansoni inositol monophosphatase 0.003 0.0352 0.0326
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0129761 0.5 0.5
Schistosoma mansoni nuclear receptor 0.0061 0.0931 0.0906
Schistosoma mansoni transcription factor LCR-F1 0.0029 0.0338 0.0311
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0069 0.1066 0.1042
Schistosoma mansoni nuclear receptor 0.0061 0.0931 0.0906

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.2 uM Concentration required to reduce incorporation of [3H]-TdR in drug-treated cultures of intracellular Leishmania major to 50% of controls ChEMBL. 9258370
IC50 (functional) = 0.2 uM Concentration required to reduce incorporation of [3H]-TdR in drug-treated cultures of intracellular Leishmania major to 50% of controls ChEMBL. 9258370
IC50 (functional) = 2 uM Concentration required to reduce the growth of human Jurkat cells to 50% of control cultures ChEMBL. 9258370
IC50 (functional) = 2 uM Concentration required to reduce the growth of human Jurkat cells to 50% of control cultures ChEMBL. 9258370
Therapeutic index (ADMET) = 10 In vitro therapeutic index calculated as the IC50 ratio of Jurkat cells to that of Leishmania major. ChEMBL. 9258370
Therapeutic index (ADMET) = 10 In vitro therapeutic index calculated as the IC50 ratio of Jurkat cells to that of Leishmania major. ChEMBL. 9258370

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Leishmania major ChEMBL23 9258370
Homo sapiens ChEMBL23 9258370

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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