TDR Targets

Basic information

Technical information

TDR Targets ID: 147944
Name: N,N-dimethyl-2-[3-[4-[2-(trifluoromethyl)phen yl]piperazin-1-yl]propylamino]pyridine-3-carb oxamide
MW: 435.486 | Formula: C22H28F3N5O
H donors: 1 H acceptors: 2 LogP: 4.05 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1cccnc1NCCCN1CCN(CC1)c1ccccc1C(F)(F)F)N(C)C
InChi: 1S/C22H28F3N5O/c1-28(2)21(31)17-7-5-10-26-20(17)27-11-6-12-29-13-15-30(16-14-29)19-9-4-3-8-18(19)22(23,24)25/h3-5,7-10H,6,11-16H2,1-2H3,(H,26,27)
InChiKey: FAEPBXVYMFXGCS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N,N-dimethyl-2-[3-[4-[2-(trifluoromethyl)phenyl]-1-piperazinyl]propylamino]-3-pyridinecarboxamide
N,N-dimethyl-2-[3-[4-[2-(trifluoromethyl)phenyl]piperazino]propylamino]nicotinamide
N,N-dimethyl-2-[3-[4-[2-(trifluoromethyl)phenyl]piperazin-1-yl]propylamino]nicotinamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Alpha-1d adrenergic receptor	Starlite/ChEMBL	References
Oryctolagus cuniculus	Alpha-1a adrenergic receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Get druggable targets OG5_128924	All targets in OG5_128924
Schistosoma japonicum	Alpha-1D adrenergic receptor, putative	Get druggable targets OG5_128924	All targets in OG5_128924
Schistosoma mansoni	amine GPCR	Get druggable targets OG5_128924	All targets in OG5_128924

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma japonicum	ko:K04136 adrenergic receptor, alpha 1b, putative	Alpha-1a adrenergic receptor	466 aa	395 aa	31.1 %
Echinococcus multilocularis	g protein coupled receptor	Alpha-1a adrenergic receptor	466 aa	396 aa	21.7 %
Echinococcus granulosus	g protein coupled receptor	Alpha-1a adrenergic receptor	466 aa	397 aa	20.9 %
Echinococcus granulosus	biogenic amine 5HT receptor	Alpha-1a adrenergic receptor	466 aa	416 aa	32.0 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Alpha-1a adrenergic receptor	466 aa	446 aa	30.7 %
Echinococcus granulosus	g protein coupled receptor	Alpha-1a adrenergic receptor	466 aa	415 aa	21.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0484	0.1218
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0484	0.2156
Leishmania major	pentamidine resistance protein 1	0.0023	0.027	0.1503
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0105	0.216	1
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0484	0.0461
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0169	0.3649	0.3633
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.216	1
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0283	0.5182
Loa Loa (eye worm)	hypothetical protein	0.0176	0.38	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0073	0.1425	0.6561
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0073	0.1425	0.6461
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0484	0.0703
Plasmodium falciparum	multidrug resistance protein 2	0.0023	0.027	0.0247
Echinococcus granulosus	hyperpolarization activated cyclic	0.002	0.0211	0.0878
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0493	0.1973
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.002	0.0211	0.0878
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.002	0.0211	0.0418
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.0438	0.1942
Schistosoma mansoni	glucose transport protein	0.0105	0.216	0.4776
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0023	0.027	0.2549
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.002	0.0211	0.0418
Schistosoma mansoni	multidrug resistance protein	0.0023	0.027	0.055
Brugia malayi	Sugar transporter family protein	0.0015	0.0084	0.028
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0589	1
Entamoeba histolytica	protein kinase, putative	0.0032	0.0484	0.1978
Entamoeba histolytica	hypothetical protein	0.0023	0.0283	0.0269
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0589	1
Echinococcus granulosus	voltage gated potassium channel	0.0027	0.0373	0.1639
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0084	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0158
Schistosoma mansoni	voltage-gated potassium channel	0.0017	0.014	0.0259
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0023	0.027	0.3687
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0493	0.8107
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0073	0.1425	0.6561
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0023	0.027	0.0376
Brugia malayi	hypothetical protein	0.0023	0.027	0.1152
Schistosoma mansoni	ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6)	0.0022	0.0252	0.0509
Brugia malayi	ABC transporter transmembrane region family protein	0.0022	0.0252	0.1066
Plasmodium falciparum	protein kinase 7	0.0296	0.6571	0.6563
Loa Loa (eye worm)	multidrug resistance protein 3	0.0073	0.1425	0.3711
Plasmodium vivax	multidrug resistance-associated protein 2, putative	0.0023	0.027	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0158
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0012	0.0024	0.0004
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0082	0.1631	0.7524
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0493	0.1973
Schistosoma mansoni	sugar transporter	0.0015	0.0084	0.0134
Trypanosoma cruzi	ABC transporter, mitochondrial, putative	0.0023	0.027	0.3687
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0493	0.8107
Loa Loa (eye worm)	ABC transporter	0.0023	0.027	0.0652
Plasmodium vivax	ABC transporter B family member 7, putative	0.0023	0.027	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0158
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.395
Leishmania major	ATP-binding cassette protein subfamily B, member 1, putative	0.0023	0.027	0.1503
Echinococcus granulosus	multidrug resistance protein 1	0.0073	0.1425	0.6561
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.002	0.0211	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0023	0.027	0.0652
Schistosoma mansoni	hypothetical protein	0.0105	0.216	0.4776
Echinococcus granulosus	ATP binding cassette sub family B	0.0022	0.0252	0.1069
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0484	0.2156
Plasmodium vivax	ABC transporter B family member 6, putative	0.0023	0.027	0.0188
Schistosoma mansoni	amine GPCR	0.0206	0.4497	1
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0073	0.1425	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0082	0.1631	0.4256
Trichomonas vaginalis	taga, putative	0.0073	0.1425	0.6461
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0027	0.0373	0.1639
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0484	0.2156
Plasmodium falciparum	ABC transporter B family member 7, putative	0.0023	0.027	0.0247
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0073	0.1425	0.6561
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.002	0.0211	0.0878
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0493	0.8107
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.002	0.0211	0.0878
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0073	0.1425	0.6461
Schistosoma mansoni	sugar transporter	0.0015	0.0084	0.0134
Echinococcus multilocularis	ATP binding cassette sub family B	0.0023	0.027	0.1155
Schistosoma mansoni	voltage-gated potassium channel	0.0089	0.1794	0.3957
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0283	1
Schistosoma mansoni	voltage-gated potassium channel	0.0027	0.0373	0.0781
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0493	0.8107
Echinococcus multilocularis	hyperpolarization activated cyclic	0.002	0.0211	0.0878
Toxoplasma gondii	sugar transporter ST3	0.0015	0.0084	0.0091
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.8107
Echinococcus granulosus	sodium channel protein	0.0083	0.1661	0.7665
Trichomonas vaginalis	abcb9, putative	0.0073	0.1425	0.6461
Plasmodium falciparum	ABC transporter B family member 3, putative	0.0023	0.027	0.0247
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0484	0.2156
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0083	0.1661	0.7665
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0202	0.0882
Mycobacterium ulcerans	sugar transporter	0.0015	0.0084	0.2954
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0037	0.0589	0.0863
Echinococcus granulosus	multidrug resistance protein 1	0.0051	0.0918	0.4186
Toxoplasma gondii	ATP-binding cassette sub-family B member 5	0.0023	0.027	0.0376
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0589	0.3451
Trichomonas vaginalis	abcb9, putative	0.0073	0.1425	0.6461
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0084	0.0283
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0023	0.027	0.3687
Giardia lamblia	Multidrug resistance-associated protein 1	0.0022	0.0252	0.4361
Plasmodium falciparum	multidrug resistance-associated protein 1	0.0023	0.027	0.0247
Plasmodium falciparum	ABC transporter B family member 5, putative	0.0023	0.027	0.0247
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0283	0.058
Echinococcus multilocularis	voltage gated potassium channel	0.0027	0.0373	0.1639
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0252	0.0603
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0217	0.0641
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0169	0.3649	0.5536
Leishmania major	hypothetical protein, conserved	0.0015	0.0084	0.0365
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0469	0.1178
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0105	0.216	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0073	0.1425	0.6461
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.216	1
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0084	0.0283
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0027	0.0373	0.1639
Leishmania major	ATP-binding cassette protein subfamily B, member 3, putative	0.0023	0.027	0.1503
Trypanosoma cruzi	hexose transporter	0.0032	0.0493	0.8107
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0444	1	1
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0023	0.027	0.9531
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0158
Brugia malayi	ABC transporter family protein	0.0023	0.027	0.1152
Wolbachia endosymbiont of Brugia malayi	ABC-type multidrug transport system, ATPase and permease component	0.0023	0.027	1
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0169	0.3649	0.3595
Brugia malayi	multidrug Resistance Protein family member (mrp-5), putative	0.0023	0.027	0.1152
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0493	0.2867
Giardia lamblia	Multidrug resistance-associated protein 1	0.0023	0.027	0.4837
Trichomonas vaginalis	conserved hypothetical protein	0.0105	0.216	1
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0283	0.0396
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.0023	0.027	0.0652
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0073	0.1425	0.6461
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0252	0.0809
Echinococcus granulosus	multidrug resistance protein 1	0.0073	0.1425	0.6561
Brugia malayi	hypothetical protein	0.0015	0.0084	0.028
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0073	0.1425	0.6461
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.002	0.0211	0.0418
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0023	0.027	0.3687
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0484	0.7919
Echinococcus granulosus	multidrug resistance associated protein 7	0.0023	0.027	0.1155
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0023	0.027	0.2549
Echinococcus granulosus	multidrug resistance protein 1	0.0073	0.1425	0.6561
Schistosoma mansoni	protein kinase	0.0032	0.0484	0.1028
Echinococcus granulosus	cGMP dependent protein kinase	0.0012	0.0024	0.0004
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.002	0.0211	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0176	0.38	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0283	0.0687
Entamoeba histolytica	P-glycoprotein 6, putative	0.0023	0.027	0.0156
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.8107
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.8107
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0469	0.0995
Leishmania major	myo-inositol/proton symporter (MIT)	0.0015	0.0084	0.0365
Loa Loa (eye worm)	ABC transporter	0.0023	0.027	0.0652
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0084	0.028
Leishmania major	ATP-binding cassette protein subfamily C, member 5, putative	0.0023	0.027	0.1503
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.002	0.0211	0.0418
Brugia malayi	Cyclic-nucleotide gated cation channel	0.002	0.0211	0.0874
Echinococcus granulosus	ATP binding cassette sub family B	0.0023	0.027	0.1155
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0084	0.2954
Schistosoma mansoni	glucose transport protein	0.0105	0.216	0.4776
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0493	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0158
Leishmania major	ATP-binding cassette protein subfamily C, member 8, putative	0.0023	0.027	0.1503
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0105	0.216	1
Trypanosoma brucei	multidrug resistance protein E	0.0023	0.027	0.3687
Loa Loa (eye worm)	hypothetical protein	0.002	0.0211	0.0495
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0469	0.185
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0073	0.1425	0.6461
Leishmania major	glucose transporter, lmgt3	0.0032	0.0493	0.2867
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0073	0.1425	0.6461
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0484	0.0703
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0012	0.0024	0.0004
Trypanosoma cruzi	multidrug resistance protein E, putative	0.0023	0.027	0.3687
Echinococcus multilocularis	ATP binding cassette sub family B	0.0023	0.027	0.1155
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0484	0.0404
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0023	0.027	0.0156
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0084	0.0283
Leishmania major	p-glycoprotein	0.0073	0.1425	0.8559
Trichomonas vaginalis	ABC transporter, putative	0.0073	0.1425	0.6461
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0073	0.1425	0.6461
Trichomonas vaginalis	abcb9, putative	0.0073	0.1425	0.6461
Leishmania major	ATP-binding cassette protein subfamily C, member 2, putative	0.0023	0.027	0.1503
Brugia malayi	hypothetical protein	0.0015	0.0084	0.028
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.1584
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0484	0.0404
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0469	0.0995
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0084	0.0283
Echinococcus granulosus	solute carrier family 22	0.0015	0.0084	0.0283
Plasmodium vivax	proline--tRNA ligase, putative	0.0037	0.0589	0.051
Schistosoma mansoni	multidrug resistance protein	0.0073	0.1425	0.3133
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0073	0.1425	0.6461
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1397	0.3637
Toxoplasma gondii	sugar transporter ST1	0.0015	0.0084	0.0091
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0283	0.1217
Schistosoma mansoni	glucose transporter	0.0015	0.0084	0.0134
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.0042	0.0046
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0484	0.1927
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.002	0.0211	0.0612
Giardia lamblia	Hypothetical protein	0.0022	0.0252	0.4361
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0283	0.3046
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0469	0.2083
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0072	0.1407	0.6476
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0252	0.0603
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0023	0.027	0.0897
Echinococcus multilocularis	hyperpolarization activated cyclic	0.002	0.0211	0.0878
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0484	0.2156
Brugia malayi	multidrug resistance protein 3	0.0073	0.1425	0.656
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0493	0.8107
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0469	0.2086
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0283	1
Entamoeba histolytica	P-glycoprotein 5, putative	0.0073	0.1425	1
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0484	0.0461
Plasmodium vivax	ABC transporter B family member 5, putative	0.0023	0.027	0.0188
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0073	0.1425	0.6461
Plasmodium vivax	multidrug resistance-associated protein 1, putative	0.0023	0.027	0.0188
Plasmodium falciparum	ABC transporter B family member 4, putative	0.0023	0.027	0.0247
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0022	0.0252	0.0809
Entamoeba histolytica	P-glycoprotein 6, putative	0.0023	0.027	0.0156
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0082	0.1631	0.7523
Entamoeba histolytica	P-glycoprotein-2	0.0073	0.1425	1
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.0176	0.38	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.216	1
Entamoeba histolytica	multidrug resistance protein, putative	0.0023	0.027	0.0156
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0469	1
Echinococcus multilocularis	sodium channel protein	0.0083	0.1661	0.7665
Brugia malayi	ABC transporter transmembrane region family protein	0.0023	0.027	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0469	0.1178
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.0438	0.1942
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0283	0.0201
Toxoplasma gondii	protein kinase, putative	0.0296	0.6571	1
Toxoplasma gondii	hypothetical protein	0.0176	0.38	0.5768
Entamoeba histolytica	P-glycoprotein-5	0.0073	0.1425	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0158
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0073	0.1425	0.6461
Entamoeba histolytica	hypothetical protein	0.0023	0.027	0.0156
Entamoeba histolytica	P-glycoprotein-2	0.0073	0.1425	1
Toxoplasma gondii	transporter, major facilitator family protein	0.0015	0.0084	0.0091
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.0961
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0073	0.1425	0.6561
Giardia lamblia	Multidrug resistance-associated protein Mrp2	0.0022	0.0252	0.4361
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.216	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1425	0.3711
Schistosoma mansoni	ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7)	0.0023	0.027	0.055
Brugia malayi	multidrug resistance related protein 1	0.0023	0.027	0.1152
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0484	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0158
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0484	0.1218
Schistosoma mansoni	voltage-gated potassium channel	0.0089	0.1794	0.3957
Schistosoma mansoni	voltage-gated potassium channel	0.002	0.0211	0.0418
Leishmania major	ATP-binding cassette protein subfamily C, member 1, putative	0.0023	0.027	0.1503
Loa Loa (eye worm)	hypothetical protein	0.0023	0.027	0.0652
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0105	0.216	1
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0084	0.2954
Schistosoma mansoni	protein kinase	0.0032	0.0484	0.1028
Toxoplasma gondii	sugar transporter ST2	0.0015	0.0084	0.0091
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.8107
Schistosoma mansoni	multidrug resistance protein	0.0023	0.027	0.055
Schistosoma mansoni	multidrug resistance protein	0.0073	0.1425	0.3133
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.8107
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.002	0.0211	0.0612
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0073	0.1425	0.6561
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0073	0.1425	0.6461
Loa Loa (eye worm)	sugar transporter	0.0015	0.0084	0.0158
Schistosoma mansoni	multidrug resistance protein	0.0023	0.027	0.055
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0084	0.028
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0084	0.0134
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0493	0.8107
Plasmodium vivax	multidrug resistance protein 1, putative	0.0073	0.1425	0.1353
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0073	0.1425	1
Brugia malayi	Sugar transporter family protein	0.0105	0.216	1
Echinococcus multilocularis	expressed conserved protein	0.0012	0.0024	0.0004
Brugia malayi	ABC transporter family protein	0.0023	0.027	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0158
Mycobacterium ulcerans	component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD	0.0023	0.027	0.9531
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0073	0.1425	0.6561
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0484	0.1218
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0333	0.0818
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0084	0.0283
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0484	0.2156
Leishmania major	p-glycoprotein e	0.0023	0.027	0.1503
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0283	0.1214
Echinococcus granulosus	multidrug resistance protein 1	0.0051	0.0918	0.4186
Echinococcus granulosus	solute carrier family 22	0.0015	0.0084	0.0283
Schistosoma mansoni	multidrug resistance protein	0.0023	0.027	0.055
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0484	0.2153
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0023	0.027	0.9531
Loa Loa (eye worm)	hypothetical protein	0.0176	0.38	1
Entamoeba histolytica	P-glycoprotein-1	0.0073	0.1425	1
Schistosoma mansoni	multidrug resistance protein	0.0022	0.0252	0.0509
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0022	0.0252	0.0809
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0073	0.1425	0.3711
Echinococcus multilocularis	ATP binding cassette sub family B	0.0023	0.027	0.1155
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0023	0.027	0.0376
Toxoplasma gondii	facilitative glucose transporter GT1	0.0105	0.216	0.3263
Echinococcus granulosus	multidrug resistance associated protein 1	0.0023	0.027	0.1155
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0283	0.058
Plasmodium falciparum	hexose transporter	0.0105	0.216	0.2142
Giardia lamblia	ABC transporter, putative	0.0023	0.027	0.4837
Echinococcus granulosus	ATP binding cassette sub family B	0.0023	0.027	0.1155
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0073	0.1425	0.6461
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.8107
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0072	0.1398	0.6329
Trichomonas vaginalis	ABC transporter, putative	0.0073	0.1425	0.6461
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0051	0.0918	0.4016
Plasmodium falciparum	ABC transporter B family member 6, putative	0.0023	0.027	0.0247
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0154	0.1383
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0023	0.027	0.0376
Leishmania major	protein kinase, putative	0.0032	0.0484	0.2809
Echinococcus granulosus	hyperpolarization activated cyclic	0.002	0.0211	0.0878
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0084	0.028
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.395
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0283	0.1217
Echinococcus multilocularis	General substrate transporter	0.009	0.1821	0.841
Schistosoma mansoni	voltage-gated potassium channel	0.0027	0.0373	0.0781
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0022	0.0252	0.0809
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.002	0.0211	0.0878
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0493	0.1973
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0084	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0023	0.027	0.0652
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0484	0.0461
Schistosoma mansoni	multidrug resistance protein	0.0073	0.1425	0.3133
Entamoeba histolytica	ABC transporter, putative	0.0023	0.027	0.0156
Schistosoma mansoni	glucose transport protein	0.0105	0.216	0.4776
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0202	0.0882
Brugia malayi	Sugar transporter family protein	0.0015	0.0084	0.028
Schistosoma mansoni	60S ribosomal protein L21	0.0017	0.014	0.0259
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0073	0.1425	0.6461
Brugia malayi	major facilitator superfamily protein	0.0015	0.0084	0.028
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0073	0.1425	0.6461
Brugia malayi	ABC transporter	0.0022	0.0252	0.1066
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0073	0.1425	0.6561
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0073	0.1425	0.6561
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.002	0.0211	0.0878
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0073	0.1425	0.6461
Echinococcus multilocularis	ATP binding cassette sub family B	0.0072	0.1407	0.6476
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0073	0.1425	0.2141
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1425	0.3711
Echinococcus multilocularis	multidrug resistance protein 1	0.0073	0.1425	0.6561
Echinococcus granulosus	General substrate transporter	0.009	0.1821	0.841
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0158
Plasmodium vivax	ABC transporter B family member 4, putative	0.0023	0.027	0.0188
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.002	0.0211	0.0878
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0023	0.027	0.0376
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0589	0.3451
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0283	0.026
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0589	1
Toxoplasma gondii	ABC transporter, putative	0.0023	0.027	0.0376
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0023	0.027	0.0376
Echinococcus multilocularis		0.0023	0.027	0.1155
Leishmania major	ATP-binding cassette protein subfamily C, member 6, putative	0.0023	0.027	0.1503
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0083	0.1661	1
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0023	0.027	0.0156
Trypanosoma cruzi	ABC transporter of the mitochondrion, putative	0.0023	0.027	0.3687
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0082	0.1631	0.7524
Echinococcus multilocularis	multidrug resistance protein 1	0.0051	0.0918	0.4186
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0469	0.1855
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.8107
Trypanosoma brucei	ABC transporter, mitochondrial, putative	0.0023	0.027	0.3687
Wolbachia endosymbiont of Brugia malayi	ABC-type protease secretion system, ATPase and permease component, AprD	0.0023	0.027	1
Schistosoma mansoni	sugar transporter	0.0015	0.0084	0.0134
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0084	0.0158
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0072	0.1398	0.6329
Entamoeba histolytica	P-glycoprotein-2, putative	0.0073	0.1425	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0073	0.1425	0.6561
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0469	0.2083
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0027	0.0373	0.1636
Toxoplasma gondii	ABC transporter family protein	0.0023	0.027	0.0376
Leishmania major	glucose transporter, lmgt2	0.0032	0.0493	0.2867
Schistosoma mansoni	protein kinase	0.0032	0.0484	0.1028
Mycobacterium tuberculosis	Iron-regulated transporter IrtA	0.0023	0.027	0.1389
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0493	0.8107
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0493	0.1973
Echinococcus multilocularis	multidrug resistance protein 1	0.0073	0.1425	0.6561
Schistosoma mansoni	smdr1	0.0023	0.027	0.055
Brugia malayi	ABC transporter family protein	0.0073	0.1425	0.656
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.002	0.0211	0.0495
Plasmodium vivax	hexose transporter	0.0105	0.216	0.2094
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0484	0.0703
Trichomonas vaginalis	ABC transporter, putative	0.0073	0.1425	0.6461
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0023	0.027	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1407	0.3663
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0073	0.1425	0.6461
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0484	0.0404
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0012	0.0024	0.0004
Schistosoma mansoni	smdr2	0.0073	0.1425	0.3133
Brugia malayi	ABC transporter	0.0023	0.027	0.1152
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0084	0.0283
Trypanosoma brucei	p-glycoprotein	0.0023	0.027	0.3687
Plasmodium vivax	ABC transporter B family member 3, putative	0.0023	0.027	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0373	0.0925
Trypanosoma brucei	ABC transporter of the mitochondrion, putative	0.0023	0.027	0.3687
Schistosoma mansoni	multidrug resistance protein	0.0023	0.027	0.055
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.8107
Brugia malayi	Cam kinase protein 1	0.0032	0.0484	0.2153
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0023	0.027	0.9531
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0073	0.1425	0.6461
Echinococcus multilocularis	ATP binding cassette sub family B	0.0023	0.027	0.1155
Plasmodium falciparum	multidrug resistance-associated protein 2	0.0023	0.027	0.0247
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0084	0.0283
Plasmodium vivax	multidrug resistance protein 2, putative	0.0023	0.027	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0158
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.002	0.0211	0.0878
Plasmodium falciparum	proline--tRNA ligase	0.0037	0.0589	0.0566
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0493	0.1973
Echinococcus granulosus	solute carrier family 22	0.0015	0.0084	0.0283
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0023	0.027	0.0156
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0493	0.8107
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0283	0.1987
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0084	0.2954
Brugia malayi	ABC transporter transmembrane region family protein	0.0023	0.027	0.1152
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0073	0.1425	0.6461
Loa Loa (eye worm)	ABC transporter	0.0023	0.027	0.0652
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0073	0.1425	0.6461
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0484	0.2156
Brugia malayi	major facilitator superfamily protein	0.0015	0.0084	0.028
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0073	0.1425	0.6461
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0484	0.1028
Echinococcus granulosus	solute carrier family 22	0.0015	0.0084	0.0283
Mycobacterium ulcerans	drugs-transport transmembrane ATP-binding protein ABC transporter	0.0023	0.027	0.9531
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0073	0.1425	0.8559
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0012	0.0024	0.0004
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0015	0.0084	0.006
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0023	0.027	0.0376
Trichomonas vaginalis	ABC transporter, putative	0.0073	0.1425	0.6461
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0484	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0158
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0032	0.0484	0.1978
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0484	0.0461
Leishmania major	ABC-thiol transporter	0.0023	0.027	0.1503
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0469	0.2086
Brugia malayi	P-glycoprotein-like protein	0.0023	0.027	0.1152
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0484	0.2156
Onchocerca volvulus		0.0073	0.1425	1
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0073	0.1425	0.2141
Loa Loa (eye worm)	sugar transporter	0.0105	0.216	0.5658
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0158
Giardia lamblia	MRP-like ABC transporter	0.0023	0.027	0.4837
Mycobacterium tuberculosis	Probable drugs-transport transmembrane ATP-binding protein ABC transporter	0.0023	0.027	0.1389
Plasmodium falciparum	multidrug resistance protein 1	0.0073	0.1425	0.1405
Brugia malayi	hypothetical protein	0.0015	0.0084	0.028
Brugia malayi	ABC transporter family protein	0.0023	0.027	0.1152
Giardia lamblia	Multidrug resistance-associated protein 1	0.0023	0.027	0.4837
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0493	0.1973
Echinococcus multilocularis	multidrug resistance associated protein 7	0.0023	0.027	0.1155
Leishmania major	glucose transporter, lmgt1	0.0032	0.0493	0.2867
Entamoeba histolytica	P-glyco protein 6, putative	0.0073	0.1425	1
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0023	0.027	0.3687
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0469	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0158
Schistosoma mansoni	sugar transporter	0.0015	0.0084	0.0134
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0073	0.1425	0.6461
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0158
Echinococcus multilocularis	multidrug resistance associated protein 1	0.0023	0.027	0.1155

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (functional)	= 6.5	Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor	ChEMBL.	9276013
Kd (functional)	= 7.9	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL.	9276013
pA2 (functional)	= 6.5	Antagonistic activity against rat aorta for affinity estimates representative of the Alpha-1D adrenergic receptor	ChEMBL.	9276013
pA2 (functional)	= 7.9	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL.	9276013

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL314114
PubChem: 10574889

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 147944