Detailed information for compound 1483436

Basic information

Technical information
  • TDR Targets ID: 1483436
  • Name: 1-(4-bromo-2,6-difluorophenoxy)-3-(3,4-dihydr o-1H-isoquinolin-2-yl)propan-2-ol hydrochlori de
  • MW: 434.703 | Formula: C18H19BrClF2NO2
  • H donors: 1 H acceptors: 1 LogP: 4.53 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(CN1CCc2c(C1)cccc2)COc1c(F)cc(cc1F)Br.Cl
  • InChi: 1S/C18H18BrF2NO2.ClH/c19-14-7-16(20)18(17(21)8-14)24-11-15(23)10-22-6-5-12-3-1-2-4-13(12)9-22;/h1-4,7-8,15,23H,5-6,9-11H2;1H
  • InChiKey: KSZYDWQSVIXXBI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(4-bromo-2,6-difluoro-phenoxy)-3-(3,4-dihydro-1H-isoquinolin-2-yl)propan-2-ol hydrochloride
  • SMR000497796
  • 1-(4-bromo-2,6-difluorophenoxy)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-propanol hydrochloride
  • MLS001000864

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0023 0.0349 0.0349
Leishmania major cyclic nucleotide-binding protein-like protein 0.0015 0.0175 1
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0015 0.0175 0.0175
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.1066 0.1768
Onchocerca volvulus 0.0029 0.0497 0.9194
Trypanosoma cruzi cAMP binding protein, putative 0.0015 0.0175 1
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0015 0.0175 0.0291
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0015 0.0175 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0349 0.1258
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0218 0.0218
Leishmania major hypothetical protein, conserved 0.0015 0.0175 1
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0015 0.0175 0.0175
Onchocerca volvulus 0.0031 0.054 1
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0015 0.0175 0.5
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0015 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0029 0.0484 0.0803
Echinococcus granulosus cpg binding protein 0.0033 0.0581 0.0581
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0185 0.0307
Schistosoma mansoni voltage-gated potassium channel 0.0125 0.2714 0.2714
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0175 1
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0015 0.0175 0.0175
Schistosoma mansoni hypothetical protein 0.0017 0.0218 0.0218
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0015 0.0175 0.0477
Onchocerca volvulus 0.0015 0.0175 0.3244
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.2189 0.2189
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0115 0.2471 0.4098
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0218 0.0218
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0015 0.0175 0.0298
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0047 0.0047
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0218 0.0362
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0015 0.0175 0.0291
Loa Loa (eye worm) hypothetical protein 0.0263 0.5885 0.9759
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0011 0.0069 0.3934
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0015 0.0175 0.0175
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0033 0.0592 0.0982
Loa Loa (eye worm) hypothetical protein 0.0013 0.0137 0.0228
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0015 0.0175 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.0175 0.5
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.1179 0.2004
Echinococcus granulosus hyperpolarization activated cyclic 0.0023 0.0349 0.0349
Treponema pallidum catabolite gene activator (Crp) 0.0015 0.0175 0.5
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.015 0.015
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0015 0.0175 1
Schistosoma mansoni hypothetical protein 0.0017 0.0218 0.0218
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0497 0.0824
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.054 0.0896
Echinococcus granulosus patatin phospholipase domain containing protein 0.0015 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0033 0.0592 0.0982
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0015 0.0175 0.5
Brugia malayi intermediate filament protein 0.0029 0.0497 0.0824
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0175 0.0175
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0674 0.1117
Leishmania major protein kinase, putative 0.0015 0.0175 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0023 0.0349 0.0349
Echinococcus granulosus GPCR family 2 0.0017 0.0218 0.0218
Brugia malayi Cyclic-nucleotide gated cation channel 0.0023 0.0349 0.0579
Trypanosoma brucei cAMP binding protein, putative 0.0015 0.0175 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.0175 0.5
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0185 0.0307
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0015 0.0175 0.5
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0015 0.0175 0.0175
Echinococcus granulosus geminin 0.0197 0.4365 0.4365
Loa Loa (eye worm) hypothetical protein 0.0015 0.0175 0.0291
Echinococcus multilocularis GPCR, family 2 0.0017 0.0218 0.0218
Onchocerca volvulus 0.0015 0.0175 0.3244
Mycobacterium ulcerans hypothetical protein 0.0015 0.0175 0.5
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0015 0.0175 0.3244
Leishmania major protein kinase, putative 0.0015 0.0175 1
Mycobacterium tuberculosis Conserved protein 0.0015 0.0175 0.5
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0218 0.0362
Schistosoma mansoni hypothetical protein 0.0037 0.0674 0.0674
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0015 0.0175 0.0477
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0349 0.1258
Schistosoma mansoni cpg binding protein 0.0031 0.054 0.054
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0015 0.0175 0.0175
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0015 0.0175 0.0175
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0023 0.0349 0.0349
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.2189 0.2189
Schistosoma mansoni hypothetical protein 0.0017 0.0218 0.0218
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0023 0.0349 0.0349
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0015 0.0175 0.0175
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0044 0.0073
Leishmania major hypothetical protein, unknown function 0.0015 0.0175 1
Schistosoma mansoni hypothetical protein 0.0197 0.4365 0.4365
Echinococcus granulosus cGMP dependent protein kinase 0.0015 0.0175 0.0175
Trypanosoma brucei cAMP response protein 1, putative 0.0015 0.0175 1
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0023 0.0349 0.0349
Echinococcus multilocularis cpg binding protein 0.0033 0.0581 0.0581
Schistosoma mansoni hypothetical protein 0.0017 0.0218 0.0218
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.1341 0.1341
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0015 0.0175 0.0291
Schistosoma mansoni voltage-gated potassium channel 0.0125 0.2714 0.2714
Echinococcus multilocularis hyperpolarization activated cyclic 0.0023 0.0349 0.0349
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0102 0.2189 0.363
Schistosoma mansoni 60S ribosomal protein L21 0.0018 0.0243 0.0243
Mycobacterium ulcerans hypothetical protein 0.0015 0.0175 0.5
Echinococcus granulosus cGMP dependent protein kinase 1 0.0015 0.0175 0.0175
Echinococcus granulosus cGMP dependent protein kinase 1 0.0015 0.0175 0.0175
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.0023 0.0349 0.0579
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0023 0.0349 0.0349
Schistosoma mansoni hypothetical protein 0.0197 0.4365 0.4365
Schistosoma mansoni lamin 0.0029 0.0497 0.0497
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0218 0.0362
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0015 0.0175 0.0175
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0015 0.0175 0.0298
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0015 0.0175 0.0298
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0015 0.0175 0.0175
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0023 0.0349 0.0349
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0015 0.0175 0.0477
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0015 0.0175 0.0175
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0015 0.0175 0.0175
Mycobacterium leprae Conserved hypothetical protein 0.0015 0.0175 1
Brugia malayi CXXC zinc finger family protein 0.0031 0.054 0.0896
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0592 0.0592
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0263 0.5885 0.9759
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.1066 0.1768
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0023 0.0349 0.0579
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0015 0.0175 0.0175
Loa Loa (eye worm) histone methyltransferase 0.001 0.0047 0.0078
Loa Loa (eye worm) hypothetical protein 0.0017 0.0218 0.0362
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0497 0.0824
Echinococcus granulosus lamin dm0 0.0029 0.0497 0.0497
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0015 0.0175 0.0175
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0015 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.01 0.2122 0.3518
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0023 0.0349 0.0349
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0269 0.603 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.2189 0.2189
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0023 0.0349 0.0349
Loa Loa (eye worm) hypothetical protein 0.0054 0.1066 0.1768
Schistosoma mansoni cpg binding protein 0.0033 0.0581 0.0581
Loa Loa (eye worm) hypothetical protein 0.0263 0.5885 0.9759
Echinococcus multilocularis dnaJ subfamily B 0.0441 1 1
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0015 0.0175 0.0175
Brugia malayi follicle stimulating hormone receptor 0.0269 0.603 1
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0015 0.0175 0.0291
Schistosoma mansoni intermediate filament proteins 0.0029 0.0497 0.0497
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0015 0.0175 0.0298
Mycobacterium ulcerans hypothetical protein 0.0015 0.0175 0.5
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0015 0.0175 0.5
Brugia malayi Egg laying defective protein 4 0.0015 0.0175 0.0291
Trypanosoma cruzi cAMP response protein 1 0.0015 0.0175 1
Toxoplasma gondii hypothetical protein 0.0263 0.5885 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0218 0.0218
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0115 0.2471 0.2471
Loa Loa (eye worm) hypothetical protein 0.0014 0.015 0.0248
Trypanosoma brucei protein kinase A regulatory subunit 0.0015 0.0175 1
Treponema pallidum cyclic nucleotide binding protein 0.0015 0.0175 0.5
Echinococcus multilocularis voltage gated potassium channel 0.0033 0.0592 0.0592
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0015 0.0175 1
Trypanosoma brucei Flagellar Member 6 0.0015 0.0175 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0015 0.0175 0.0175
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.2189 0.2189
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0349 0.0349
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0015 0.0175 0.0175
Treponema pallidum cyclic nucleotide binding protein 0.0015 0.0175 0.5
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0003 0.0003
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0015 0.0175 0.0298
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0015 0.0175 0.0175
Mycobacterium ulcerans transmembrane transport protein 0.0015 0.0175 0.5
Leishmania major hypothetical protein, conserved 0.0015 0.0175 1
Leishmania major regulatory subunit of protein kinase a-like protein 0.0015 0.0175 1
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0015 0.0175 0.0175
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0015 0.0175 0.5
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0023 0.0349 0.0579
Echinococcus multilocularis expressed conserved protein 0.0015 0.0175 0.0175
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0107 0.2297 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0033 0.0592 0.0592
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0349 0.0349
Trypanosoma cruzi cAMP response protein 1, putative 0.0015 0.0175 1
Trypanosoma cruzi Flagellar Member 6 0.0015 0.0175 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0175 0.0477
Echinococcus multilocularis geminin 0.0197 0.4365 0.4365
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0003 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.2189 0.2189
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0115 0.2471 0.2471
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0015 0.0175 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0047 0.0047
Echinococcus multilocularis musashi 0.0029 0.0497 0.0497
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.2189 0.2189
Schistosoma mansoni cpg binding protein 0.0033 0.0581 0.0581
Echinococcus multilocularis lamin 0.0029 0.0497 0.0497
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0015 0.0175 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0033 0.0592 0.0592
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0015 0.0175 0.5
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0015 0.0175 0.0298
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0115 0.2471 0.4098
Echinococcus granulosus intermediate filament protein 0.0029 0.0497 0.0497
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0015 0.0175 0.5
Schistosoma mansoni hypothetical protein 0.0441 1 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.1117
Loa Loa (eye worm) hypothetical protein 0.0029 0.0497 0.0824
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0107 0.2297 1
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0592 0.0592
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0102 0.2189 0.363
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0015 0.0175 0.0175
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0015 0.0175 0.0477
Trypanosoma cruzi protein kinase A regulatory subunit 0.0015 0.0175 1
Loa Loa (eye worm) AGC/PKG protein kinase 0.0015 0.0175 0.0291
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0263 0.5885 0.9759
Plasmodium falciparum cGMP-dependent protein kinase 0.0015 0.0175 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0175 0.0175
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0015 0.0175 1
Leishmania major protein kinase A regulatory subunit, putative 0.0015 0.0175 1
Onchocerca volvulus 0.0029 0.0497 0.9194
Echinococcus granulosus lamin 0.0029 0.0497 0.0497
Echinococcus multilocularis lamin dm0 0.0029 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.0015 0.0175 0.0291
Schistosoma mansoni lamin 0.0029 0.0497 0.0497
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0003 0.0003
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0023 0.0349 0.0349
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0497 0.0824
Loa Loa (eye worm) hypothetical protein 0.0013 0.0137 0.0228
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0003 0.0003
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0015 0.0175 0.0175
Leishmania major hypothetical protein, conserved 0.0015 0.0175 1
Treponema pallidum catabolite gene activator 0.0015 0.0175 0.5
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0011 0.0069 0.0114
Brugia malayi N-terminal motif family protein 0.0015 0.0175 0.0291
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0218 0.0218
Mycobacterium ulcerans hypothetical protein 0.0015 0.0175 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.1066 0.1768
Mycobacterium ulcerans regulatory protein 0.0015 0.0175 0.5
Schistosoma mansoni hypothetical protein 0.0011 0.0069 0.0069
Echinococcus granulosus single minded 2 0.0011 0.0069 0.0069
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0015 0.0175 0.0175
Mycobacterium ulcerans transcriptional regulatory protein 0.0015 0.0175 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.2189 0.2189
Echinococcus granulosus hyperpolarization activated cyclic 0.0023 0.0349 0.0349
Echinococcus granulosus voltage gated potassium channel 0.0033 0.0592 0.0592
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0243 0.0243
Echinococcus multilocularis hyperpolarization activated cyclic 0.0023 0.0349 0.0349
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0175 0.0175
Schistosoma mansoni hypothetical protein 0.0015 0.0175 0.0175

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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