Detailed information for compound 1487048

Basic information

Technical information
  • TDR Targets ID: 1487048
  • Name: [2-oxo-2-[4-(phenylmethyl)piperidin-1-yl]ethy l] 2,3-dimethoxybenzoate
  • MW: 397.464 | Formula: C23H27NO5
  • H donors: 0 H acceptors: 2 LogP: 3.95 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(OC)cccc1C(=O)OCC(=O)N1CCC(CC1)Cc1ccccc1
  • InChi: 1S/C23H27NO5/c1-27-20-10-6-9-19(22(20)28-2)23(26)29-16-21(25)24-13-11-18(12-14-24)15-17-7-4-3-5-8-17/h3-10,18H,11-16H2,1-2H3
  • InChiKey: LWDRKPVSJPQBLG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-oxo-2-[4-(phenylmethyl)-1-piperidyl]ethyl] 2,3-dimethoxybenzoate
  • 2,3-dimethoxybenzoic acid [2-oxo-2-[4-(phenylmethyl)-1-piperidinyl]ethyl] ester
  • 2,3-dimethoxybenzoic acid [2-[4-(benzyl)-1-piperidyl]-2-keto-ethyl] ester
  • Oprea1_726358
  • T0516-2939
  • ZINC06519374

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0081 0.0161 0.0161
Entamoeba histolytica cysteine protease, putative 0.0163 0.0444 0.0419
Echinococcus granulosus voltage gated potassium channel 0.0148 0.0393 0.0393
Trypanosoma brucei cysteine peptidase C (CPC) 0.03 0.0923 0.0895
Entamoeba histolytica cysteine proteinase, putative 0.0163 0.0444 0.0419
Giardia lamblia Histone deacetylase 0.0487 0.1568 0.1568
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.0901 0.0901
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0073 0.0133 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.0901 0.0873
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0118
Loa Loa (eye worm) voltage-gated potassium channel 0.0068 0.0118 0.0118
Echinococcus multilocularis histone deacetylase 8 0.0267 0.0807 0.0807
Schistosoma mansoni voltage-gated potassium channel 0.0068 0.0118 0.0103
Brugia malayi cathepsin Z-like cysteine proteinase 0.0073 0.0133 0.0133
Echinococcus multilocularis transient receptor potential cation channel 0.0068 0.0118 0.0118
Toxoplasma gondii hypothetical protein 0.0068 0.0118 0.0118
Schistosoma mansoni voltage-gated potassium channel 0.0068 0.0118 0.0103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.0901 0.0901
Schistosoma mansoni vesicular amine transporter 0.0148 0.0393 0.0379
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.03 0.0923 0.0909
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0068 0.0118 0.0118
Schistosoma mansoni cercarial elastase (S01 family) 0.0731 0.2417 0.2406
Plasmodium vivax vivapain-2 0.0294 0.0901 0.0873
Loa Loa (eye worm) hypothetical protein 0.0204 0.0589 0.0589
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0731 0.2417 0.2417
Onchocerca volvulus 0.0087 0.0184 0.0184
Chlamydia trachomatis dihydrofolate reductase 0.0058 0.0082 0.5
Schistosoma mansoni hypothetical protein 0.0407 0.1292 0.1279
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0731 0.2417 0.2417
Trypanosoma cruzi oligopeptidase b 0.0069 0.0121 0.0091
Loa Loa (eye worm) voltage-gated potassium channel 0.0148 0.0393 0.0393
Schistosoma mansoni dihydrofolate reductase 0.0058 0.0082 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0684 0.2254 0.2254
Loa Loa (eye worm) hypothetical protein 0.1816 0.6181 0.6181
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0731 0.2417 0.2417
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0068 0.0118 0.0118
Onchocerca volvulus 0.1943 0.662 0.662
Echinococcus granulosus tyrosine protein kinase Src42A 0.0055 0.007 0.007
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0081 0.0161 0.0161
Schistosoma mansoni histone deacetylase 4 5 0.0488 0.1572 0.1559
Brugia malayi Cathepsin L-like precursor 0.0294 0.0901 0.0901
Toxoplasma gondii hypothetical protein 0.0087 0.0184 0.0184
Loa Loa (eye worm) dihydrofolate reductase 0.0058 0.0082 0.0082
Trypanosoma cruzi cysteine protease, putative 0.0163 0.0444 0.0415
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0068 0.0118 0.0118
Plasmodium vivax serine-repeat antigen (SERA) 0.0073 0.0133 0.0103
Onchocerca volvulus 0.0078 0.0149 0.0149
Entamoeba histolytica cysteine proteinase 2 0.0163 0.0444 0.0419
Schistosoma mansoni hypothetical protein 0.0731 0.2417 0.2406
Echinococcus granulosus histone deacetylase 3 0.0487 0.1568 0.1568
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.0015
Echinococcus granulosus voltage dependent calcium channel 0.0068 0.0118 0.0118
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0079 0.0155 0.0141
Entamoeba histolytica cysteine protease, putative 0.0163 0.0444 0.0419
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.0901 0.0901
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0073 0.0133 0.0133
Trypanosoma cruzi major cysteine proteinase, putative 0.0073 0.0133 0.0103
Trypanosoma brucei potassium voltage-gated channel, putative 0.0079 0.0155 0.0126
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0068 0.0118 0.0118
Trypanosoma brucei prolyl oligopeptidase, putative 0.0069 0.0121 0.0091
Loa Loa (eye worm) hypothetical protein 0.0079 0.0155 0.0155
Echinococcus granulosus tyrosine protein kinase Lyn 0.0081 0.0161 0.0161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.0901 0.0901
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.0901 0.0901
Echinococcus granulosus cysteine protease 0.0163 0.0444 0.0444
Echinococcus granulosus c src tyrosine kinase 0.0054 0.0069 0.0069
Echinococcus multilocularis histone deacetylase 6 0.0488 0.1572 0.1572
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0294 0.0901 0.0901
Onchocerca volvulus 0.0087 0.0184 0.0184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.0901 0.0873
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0073 0.0133 0.0118
Echinococcus granulosus cathepsin L cysteine protease 0.0163 0.0444 0.0444
Onchocerca volvulus 0.0294 0.0901 0.0901
Loa Loa (eye worm) hypothetical protein 0.0079 0.0155 0.0155
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0204 0.0589 0.0589
Echinococcus multilocularis histone deacetylase 0.0488 0.1572 0.1572
Giardia lamblia Cysteine protease 0.0073 0.0133 0.0133
Trypanosoma brucei histone deacetylase 4 0.0488 0.1572 0.1546
Schistosoma mansoni voltage-gated potassium channel 0.0148 0.0393 0.0379
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0068 0.0118 0.0103
Brugia malayi Subtilase family protein 0.0554 0.1801 0.1801
Onchocerca volvulus 0.0087 0.0184 0.0184
Brugia malayi cathepsin F-like cysteine proteinase 0.009 0.0191 0.0191
Echinococcus multilocularis voltage dependent calcium channel 0.0068 0.0118 0.0118
Plasmodium falciparum serine repeat antigen 1 0.0073 0.0133 0.0103
Loa Loa (eye worm) hypothetical protein 0.0079 0.0155 0.0155
Echinococcus multilocularis growth factor receptor bound protein 2 0.0511 0.1654 0.1654
Toxoplasma gondii calcium binding egf domain-containing protein 0.0039 0.0015 0.0015
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0068 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0087 0.0184 0.0184
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0068 0.0118 0.0118
Schistosoma mansoni tyrosine kinase 0.0081 0.0161 0.0147
Echinococcus multilocularis sodium channel protein 0.0068 0.0118 0.0118
Toxoplasma gondii PAN domain-containing protein 0.0282 0.086 0.086
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0207 0.0599 0.0599
Brugia malayi hypothetical protein 0.0407 0.1292 0.1292
Brugia malayi cation channel family protein 0.0068 0.0118 0.0118
Onchocerca volvulus Cathepsin F homolog 0.0294 0.0901 0.0901
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.2917 1 1
Trypanosoma brucei potassium voltage-gated channel, putative 0.0079 0.0155 0.0126
Toxoplasma gondii hypothetical protein 0.0087 0.0184 0.0184
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0068 0.0118 0.0103
Toxoplasma gondii transporter, cation channel family protein 0.0068 0.0118 0.0118
Entamoeba histolytica cysteine proteinase, putative 0.0163 0.0444 0.0419
Echinococcus multilocularis histone deacetylase 6 0.0512 0.1655 0.1655
Echinococcus multilocularis transient receptor potential cation channel 0.0068 0.0118 0.0118
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0809 0.2686 0.2675
Plasmodium vivax histone deacetylase, putative 0.0267 0.0807 0.0779
Echinococcus granulosus short transient receptor potential channel 6 0.0068 0.0118 0.0118
Schistosoma mansoni edp1-related 0.0079 0.0155 0.0141
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0118
Echinococcus granulosus Dipeptidyl peptidase 9 0.0153 0.0411 0.0411
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0078 0.015 0.015
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0068 0.0118 0.0118
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0201 0.0578 0.0578
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.0901 0.0873
Mycobacterium tuberculosis Probable peptidase 0.0069 0.0121 0.0039
Echinococcus granulosus integrin beta 2 0.1249 0.4212 0.4212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.0901 0.0901
Echinococcus granulosus tachykinin peptides receptor 99D 0.0547 0.1776 0.1776
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0118
Brugia malayi PAN domain containing protein 0.0087 0.0184 0.0184
Echinococcus granulosus acylamino acid releasing enzyme 0.0043 0.003 0.003
Onchocerca volvulus 0.0629 0.2064 0.2064
Onchocerca volvulus 0.0087 0.0184 0.0184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.0444 0.0415
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0809 0.2686 0.2675
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0153 0.0411 0.0382
Echinococcus granulosus transient receptor potential cation channel 0.0068 0.0118 0.0118
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1943 0.662 0.6615
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0073 0.0133 0.0133
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0073 0.0133 0.0118
Schistosoma mansoni calcium-activated potassium channel 0.0068 0.0118 0.0103
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.03 0.0923 0.0895
Leishmania major histone deacetylase, putative 0.0488 0.1572 0.1472
Loa Loa (eye worm) hypothetical protein 0.0073 0.0133 0.0133
Trypanosoma cruzi prolyl endopeptidase 0.0123 0.0307 0.0278
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.03 0.0923 0.0923
Echinococcus multilocularis NCK adaptor protein 0.0053 0.0064 0.0064
Echinococcus multilocularis voltage gated potassium channel 0.0068 0.0118 0.0118
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0073 0.0133 0.0118
Schistosoma mansoni cathepsin S (C01 family) 0.0073 0.0133 0.0118
Toxoplasma gondii histone deacetylase HDAC1 0.0488 0.1572 0.1572
Schistosoma mansoni voltage-gated potassium channel 0.0068 0.0118 0.0103
Schistosoma mansoni integrin alpha 0.0871 0.2903 0.2893
Echinococcus multilocularis thymidylate synthase 0.0143 0.0376 0.0376
Onchocerca volvulus 0.0087 0.0184 0.0184
Echinococcus multilocularis tyrosine protein kinase Srms 0.0056 0.0075 0.0075
Echinococcus granulosus laminin 0.0039 0.0015 0.0015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.0901 0.0901
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0068 0.0118 0.0118
Mycobacterium ulcerans thymidylate synthase 0.0143 0.0376 0.1256
Echinococcus granulosus Mastin 0.0731 0.2417 0.2417
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0155 0.0126
Schistosoma mansoni cathepsin C 0.0073 0.0133 0.0118
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0068 0.0118 0.0118
Onchocerca volvulus Histone deacetylase 10 homolog 0.0267 0.0807 0.0807
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0073 0.0133 0.0133
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.1582 0.537 0.537
Toxoplasma gondii histone deacetylase HDAC2 0.0487 0.1568 0.1568
Schistosoma mansoni tyrosine kinase 0.0054 0.0069 0.0054
Trypanosoma cruzi potassium voltage-gated channel, putative 0.0079 0.0155 0.0126
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0073 0.0133 0.0118
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.2917 1 1
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0068 0.0118 0.0118
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.0901 0.0901
Toxoplasma gondii PAN domain-containing protein 0.0087 0.0184 0.0184
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0087 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0407 0.1292 0.1292
Toxoplasma gondii microneme protein, putative 0.0087 0.0184 0.0184
Schistosoma mansoni two-pore calcium channel 0.0068 0.0118 0.0103
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0073 0.0133 0.0133
Echinococcus multilocularis transient receptor potential gamma protein 0.0068 0.0118 0.0118
Echinococcus multilocularis transient receptor potential cation channel 0.0068 0.0118 0.0118
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0068 0.0118 0.0118
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0123 0.0307 0.0293
Brugia malayi Papain family cysteine protease containing protein 0.0294 0.0901 0.0901
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0054 0.0069 0.0069
Brugia malayi hypothetical protein 0.0042 0.0026 0.0026
Schistosoma mansoni voltage-gated potassium channel 0.0148 0.0393 0.0379
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0069 0.0121 0.0091
Trypanosoma cruzi cysteine proteinase, putative 0.0163 0.0444 0.0415
Schistosoma mansoni voltage-gated potassium channel 0.0148 0.0393 0.0379
Echinococcus granulosus potassium voltage gated channel protein 0.0148 0.0393 0.0393
Echinococcus granulosus cathepsin l1 0.0204 0.0589 0.0589
Brugia malayi Fibulin-1 precursor 0.0039 0.0015 0.0015
Brugia malayi cathepsin B-like cysteine proteinase 0.0809 0.2686 0.2686
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.2917 1 1
Entamoeba histolytica cysteine protease, putative 0.0163 0.0444 0.0419
Giardia lamblia Cathepsin L precursor 0.0073 0.0133 0.0133
Trypanosoma brucei btb/poz domain containing protein, putative 0.0079 0.0155 0.0126
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.2917 1 1
Trichomonas vaginalis histone deacetylase, putative 0.0487 0.1568 0.1568
Echinococcus granulosus potassium voltage gated channel protein 0.1816 0.6181 0.6181
Brugia malayi Integrin alpha pat-2 precursor 0.0871 0.2903 0.2903
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0072 0.0057
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0068 0.0118 0.0103
Trypanosoma cruzi cysteine peptidase, putative 0.0294 0.0901 0.0873
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.1634 0.5548 0.5548
Echinococcus granulosus apoptotic protease activating factor 1 0.0407 0.1292 0.1292
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.0901 0.0901
Echinococcus granulosus NCK adaptor protein 0.0053 0.0064 0.0064
Loa Loa (eye worm) prolyl oligopeptidase 0.0437 0.1395 0.1395
Toxoplasma gondii PAN domain-containing protein 0.0282 0.086 0.086
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0073 0.0133 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.0901 0.0901
Leishmania major hypothetical protein, conserved 0.0079 0.0155 0.0038
Plasmodium falciparum cysteine proteinase falcipain 1 0.0163 0.0444 0.0415
Echinococcus multilocularis calcium activated potassium channel 0.0068 0.0118 0.0118
Entamoeba histolytica cysteine proteinase, putative 0.0163 0.0444 0.0419
Brugia malayi PAN domain containing protein 0.0087 0.0184 0.0184
Schistosoma mansoni voltage-gated potassium channel 0.0148 0.0393 0.0379
Brugia malayi voltage-dependent calcium channel 0.0068 0.0118 0.0118
Echinococcus granulosus prolyl endopeptidase 0.0123 0.0307 0.0307
Echinococcus multilocularis dihydrofolate reductase 0.0058 0.0082 0.0082
Plasmodium falciparum cysteine repeat modular protein 1 0.0629 0.2064 0.2039
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0068 0.0118 0.0118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0163 0.0444 0.0415
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0068 0.0118 0.0103
Plasmodium falciparum serine repeat antigen 3 0.0073 0.0133 0.0103
Giardia lamblia Cathepsin L precursor 0.0073 0.0133 0.0133
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.1634 0.5548 0.5542
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0731 0.2417 0.2406
Echinococcus multilocularis cysteine protease 0.0294 0.0901 0.0901
Loa Loa (eye worm) hypothetical protein 0.0731 0.2417 0.2417
Echinococcus multilocularis Tolloid protein 1 0.0045 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.0901 0.0901
Echinococcus granulosus BTB:POZ domain containing protein 0.0079 0.0155 0.0155
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0148 0.0393 0.0393
Echinococcus multilocularis integrin alpha ps 0.0391 0.1236 0.1236
Schistosoma mansoni hypothetical protein 0.0296 0.0906 0.0893
Loa Loa (eye worm) hypothetical protein 0.0629 0.2064 0.2064
Loa Loa (eye worm) thymidylate synthase 0.0143 0.0376 0.0376
Toxoplasma gondii kringle domain-containing protein 0.0629 0.2064 0.2064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.0901 0.0873
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0133 0.0133
Giardia lamblia Cysteine protease 0.0073 0.0133 0.0133
Echinococcus multilocularis integrin alpha ps 0.0187 0.053 0.053
Onchocerca volvulus 0.0731 0.2417 0.2417
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0068 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.1634 0.5548 0.5548
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0081 0.0161 0.0161
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0437 0.1395 0.1382
Trypanosoma cruzi histone deacetylase, putative 0.0488 0.1572 0.1546
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0153 0.0411 0.0411
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0068 0.0118 0.0103
Onchocerca volvulus Prolyl endopeptidase homolog 0.0123 0.0307 0.0307
Echinococcus multilocularis tumor protein p63 0.0232 0.0684 0.0684
Echinococcus multilocularis transient receptor potential cation channel 0.0068 0.0118 0.0118
Plasmodium falciparum serine repeat antigen 4 0.0073 0.0133 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.0901 0.0901
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0201 0.0578 0.0549
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0048 0.0048 0.0048
Echinococcus multilocularis sodium leak channel non selective protein 0.0068 0.0118 0.0118
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0069 0.0121 0.0003
Loa Loa (eye worm) histone deacetylase 7A 0.0488 0.1572 0.1572
Schistosoma mansoni cercarial elastase (S01 family) 0.0731 0.2417 0.2406
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0123 0.0307 0.0293
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0487 0.1568 0.1568
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.0444 0.0444
Toxoplasma gondii PAN domain-containing protein 0.0087 0.0184 0.0184
Echinococcus granulosus histone deacetylase 7 0.0488 0.1572 0.1572
Schistosoma mansoni histone deacetylase 1 2 3 0.0267 0.0807 0.0793
Loa Loa (eye worm) hypothetical protein 0.0053 0.0064 0.0064
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0118 0.0118
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0148 0.0393 0.0393
Schistosoma mansoni adapter molecule crk 0.0053 0.0064 0.0049
Loa Loa (eye worm) ctsf protein 0.0294 0.0901 0.0901
Echinococcus multilocularis integrin alpha ps 0.0391 0.1236 0.1236
Echinococcus multilocularis histone deacetylase 1 0.0487 0.1568 0.1568
Toxoplasma gondii cathepsin B 0.03 0.0923 0.0923
Giardia lamblia Encystation-specific protease 0.0073 0.0133 0.0133
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0731 0.2417 0.2406
Loa Loa (eye worm) subtilase 0.0554 0.1801 0.1801
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0809 0.2686 0.2675
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0148 0.0393 0.0393
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0081 0.0161 0.0161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0133 0.0133
Echinococcus granulosus shaker cognate 0.0148 0.0393 0.0393
Echinococcus granulosus potassium voltage gated channel protein 0.0068 0.0118 0.0118
Onchocerca volvulus 0.0407 0.1292 0.1292
Entamoeba histolytica prolyl oligopeptidase family protein 0.0043 0.003 0.0004
Loa Loa (eye worm) histone deacetylase 0.0488 0.1572 0.1572
Echinococcus granulosus calcium activated potassium channel 0.0068 0.0118 0.0118
Schistosoma mansoni cathepsin s 0.009 0.0191 0.0177
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0073 0.0133 0.0103
Loa Loa (eye worm) SRC-1 0.0081 0.0161 0.0161
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.0901 0.0901
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0731 0.2417 0.2417
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0133 0.0133
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0073 0.0133 0.0118
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0069 0.0121 0.0165
Loa Loa (eye worm) TK protein kinase 0.0056 0.0075 0.0075
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0079 0.0155 0.0155
Entamoeba histolytica prolyl oligopeptidase family protein 0.0043 0.003 0.0004
Onchocerca volvulus Cell death protein 3 homolog 0.0407 0.1292 0.1292
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0118
Trypanosoma cruzi histone deacetylase, putative 0.0488 0.1572 0.1546
Loa Loa (eye worm) hypothetical protein 0.0087 0.0184 0.0184
Trypanosoma brucei histone deacetylase 1 0.0487 0.1568 0.1543
Echinococcus granulosus cathepsin L cysteine proteinase 0.0294 0.0901 0.0901
Onchocerca volvulus 0.0053 0.0064 0.0064
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0068 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0073 0.0133 0.0133
Brugia malayi Sex muscle abnormal protein 5 0.0511 0.1654 0.1654
Schistosoma mansoni cercarial elastase (S01 family) 0.0731 0.2417 0.2406
Trypanosoma brucei histone deacetylase, putative 0.0488 0.1572 0.1546
Schistosoma mansoni hypothetical protein 0.0731 0.2417 0.2406
Schistosoma mansoni hypothetical protein 0.1634 0.5548 0.5542
Giardia lamblia Cathepsin B precursor 0.0073 0.0133 0.0133
Onchocerca volvulus 0.0731 0.2417 0.2417
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0294 0.0901 0.0901
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.0901 0.0901
Schistosoma mansoni cercarial elastase (S01 family) 0.0731 0.2417 0.2406
Echinococcus granulosus eukaryotic initiation factor 4A 0.2917 1 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0068 0.0118 0.0103
Toxoplasma gondii transporter, cation channel family protein 0.0068 0.0118 0.0118
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0163 0.0444 0.0415
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0118
Schistosoma mansoni cathepsin F (C01 family) 0.0204 0.0589 0.0575
Schistosoma mansoni transient receptor potential channel 0.0068 0.0118 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.0901 0.0901
Echinococcus granulosus tm gpcr rhodopsin 0.0868 0.2893 0.2893
Schistosoma mansoni voltage-gated potassium channel 0.0068 0.0118 0.0103
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0039 0.0015 0.0015
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0547 0.1776 0.1776
Echinococcus multilocularis integrin beta 2 0.1249 0.4212 0.4212
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0068 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0045 0.0038 0.0038
Brugia malayi PAN domain containing protein 0.0087 0.0184 0.0184
Plasmodium vivax histone deacetylase, putative 0.0488 0.1572 0.1546
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0068 0.0118 0.0088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0072 0.0072
Loa Loa (eye worm) potassium channel tetramerisation domain containing 3 0.0079 0.0155 0.0155
Echinococcus granulosus potassium voltage gated channel protein 0.0068 0.0118 0.0118
Echinococcus granulosus eukaryotic initiation factor 4A III 0.2917 1 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0056 0.0075 0.0075
Toxoplasma gondii microneme protein MIC4 0.0087 0.0184 0.0184
Entamoeba histolytica cysteine proteinase, putative 0.0163 0.0444 0.0419
Brugia malayi Trypsin-like protease protein 5 0.0731 0.2417 0.2417
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0073 0.0133 0.0103
Echinococcus multilocularis ryanodine receptor 44f 0.0068 0.0118 0.0118
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0201 0.0578 0.0549
Onchocerca volvulus 0.0079 0.0155 0.0155
Giardia lamblia Cysteine protease 0.0073 0.0133 0.0133
Echinococcus multilocularis caspase 2 0.0407 0.1292 0.1292
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0068 0.0118 0.0103
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0081 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0118
Entamoeba histolytica cysteine protease, putative 0.0163 0.0444 0.0419
Loa Loa (eye worm) hypothetical protein 0.009 0.0191 0.0191
Onchocerca volvulus 0.0294 0.0901 0.0901
Trypanosoma cruzi histone deacetylase, putative 0.0267 0.0807 0.0779
Echinococcus granulosus tyrosine protein kinase Src64B 0.0081 0.0161 0.0161
Brugia malayi Papain family cysteine protease containing protein 0.0073 0.0133 0.0133
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0809 0.2686 0.2675
Trypanosoma cruzi cysteine peptidase, putative 0.0294 0.0901 0.0873
Echinococcus multilocularis eukaryotic initiation factor 4A 0.2917 1 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0068 0.0118 0.0118
Echinococcus granulosus transmembrane protease serine 3 0.0731 0.2417 0.2417
Schistosoma mansoni integrin beta subunit 0.0988 0.3309 0.3299
Plasmodium vivax K+ channel tetramerisation domain containing protein 0.0079 0.0155 0.0126
Loa Loa (eye worm) integrin alpha pat-2 0.1155 0.3886 0.3886
Toxoplasma gondii histone deacetylase HDAC5 0.0267 0.0807 0.0807
Echinococcus multilocularis enteropeptidase 0.0731 0.2417 0.2417
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0068 0.0118 0.0103
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0163 0.0444 0.043
Plasmodium falciparum serine repeat antigen 2 0.0073 0.0133 0.0103
Echinococcus granulosus potassium voltage gated channel subfamily A 0.1816 0.6181 0.6181
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0123 0.0307 0.0192
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0073 0.0133 0.0133
Echinococcus multilocularis cathepsin L 0.0163 0.0444 0.0444
Leishmania major eukaryotic initiation factor 4a, putative 0.2917 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0045 0.0038 0.0038
Toxoplasma gondii hypothetical protein 0.0068 0.0118 0.0118
Onchocerca volvulus 0.0087 0.0184 0.0184
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.2917 1 1
Plasmodium vivax unspecified product 0.0073 0.0133 0.0103
Schistosoma mansoni hypothetical protein 0.0053 0.0064 0.0049
Echinococcus multilocularis potassium voltage gated channel protein 0.0068 0.0118 0.0118
Plasmodium vivax vivapain-3 0.0163 0.0444 0.0415
Schistosoma mansoni cercarial elastase (S01 family) 0.0731 0.2417 0.2406
Entamoeba histolytica cysteine protease, putative 0.0073 0.0133 0.0107
Schistosoma mansoni histone deacetylase hda2 0.0512 0.1655 0.1642
Entamoeba histolytica histone deacetylase, putative 0.0487 0.1568 0.1546
Echinococcus granulosus potassium voltage gated channel protein 0.0148 0.0393 0.0393
Onchocerca volvulus 0.0087 0.0184 0.0184
Schistosoma mansoni voltage-gated potassium channel 0.0079 0.0155 0.0141
Onchocerca volvulus 0.1634 0.5548 0.5548
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0073 0.0133 0.0133
Onchocerca volvulus 0.0087 0.0184 0.0184
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0068 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0187 0.053 0.053
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0068 0.0118 0.0103
Schistosoma mansoni voltage-gated potassium channel 0.0068 0.0118 0.0103
Echinococcus granulosus cathepsin L 0.0073 0.0133 0.0133
Echinococcus granulosus cathepsin b 0.0809 0.2686 0.2686
Schistosoma mansoni voltage-gated potassium channel 0.0068 0.0118 0.0103
Loa Loa (eye worm) hypothetical protein 0.1943 0.662 0.662
Giardia lamblia Translation initiation factor eIF-4A, putative 0.2917 1 1
Loa Loa (eye worm) histone deacetylase 3 0.0487 0.1568 0.1568
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0133 0.0133
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0068 0.0118 0.0118
Brugia malayi Muscle positioning protein 4 0.0078 0.0149 0.0149
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0079 0.0155 0.0126
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.0901 0.0901
Giardia lamblia Hypothetical protein 0.0073 0.0133 0.0133
Echinococcus multilocularis two pore calcium channel protein 2 0.0068 0.0118 0.0118
Echinococcus multilocularis transient receptor potential cation channel 0.0068 0.0118 0.0118
Echinococcus granulosus transient receptor potential gamma protein 0.0068 0.0118 0.0118
Onchocerca volvulus 0.0731 0.2417 0.2417
Echinococcus multilocularis laminin 0.0039 0.0015 0.0015
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0068 0.0118 0.0118
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0068 0.0118 0.0103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0133 0.0133
Trypanosoma cruzi cysteine peptidase, putative 0.009 0.0191 0.0162
Brugia malayi prolyl oligopeptidase family protein 0.0153 0.0411 0.0411
Echinococcus multilocularis geminin 0.0296 0.0906 0.0906
Brugia malayi hypothetical protein 0.0068 0.0116 0.0116
Loa Loa (eye worm) ryanodine receptor 0.0068 0.0118 0.0118
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0148 0.0393 0.0393
Brugia malayi PAN domain containing protein 0.0087 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0407 0.1292 0.1292
Treponema pallidum ATP-dependent RNA helicase 0.2917 1 0.5
Brugia malayi prolyl oligopeptidase family protein 0.0043 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0073 0.0133 0.0133
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0072 0.0072
Mycobacterium tuberculosis Hypothetical protein 0.0068 0.0116 0.0034
Plasmodium vivax vivapain-1 0.0163 0.0444 0.0415
Onchocerca volvulus 0.0068 0.0118 0.0118
Brugia malayi mKIAA0176 protein 0.0079 0.0155 0.0155
Echinococcus multilocularis transfer RNA-Gly 0.0148 0.0393 0.0393
Loa Loa (eye worm) Kv4.2 voltage-gated potassium channel 0.0079 0.0155 0.0155
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.2917 1 1
Echinococcus granulosus geminin 0.0296 0.0906 0.0906
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0118
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.008 0.0157 0.0076
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0118
Plasmodium falciparum kelch protein K13 0.0079 0.0155 0.0126
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0809 0.2686 0.2664
Loa Loa (eye worm) hypothetical protein 0.0203 0.0586 0.0586
Echinococcus granulosus potassium large conductance calcium activated 0.0068 0.0118 0.0118
Plasmodium vivax kelch protein K13, putative 0.0079 0.0155 0.0126
Brugia malayi K+ channel tetramerisation domain containing protein 0.0079 0.0155 0.0155
Plasmodium vivax unspecified product 0.0163 0.0444 0.0415
Loa Loa (eye worm) hypothetical protein 0.0087 0.0184 0.0184
Echinococcus granulosus hypothetical protein 0.0068 0.0118 0.0118
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0731 0.2417 0.2406
Schistosoma mansoni cercarial elastase (S01 family) 0.0731 0.2417 0.2406
Echinococcus granulosus two pore calcium channel protein 2 0.0068 0.0118 0.0118
Plasmodium falciparum serine repeat antigen 6 0.0073 0.0133 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0073 0.0133 0.0133
Leishmania major cathepsin L-like protease 0.0294 0.0901 0.0792
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0026 0.0026
Brugia malayi Cathepsin L-like precursor 0.0204 0.0589 0.0589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0204 0.0589 0.0589
Schistosoma mansoni voltage-gated potassium channel 0.0068 0.0118 0.0103
Loa Loa (eye worm) hypothetical protein 0.009 0.0191 0.0191
Brugia malayi PAN domain containing protein 0.0087 0.0184 0.0184
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0068 0.0118 0.0103
Brugia malayi Tyrosine-protein kinase abl-1 0.0056 0.0073 0.0073
Brugia malayi Cathepsin L-like precursor 0.0294 0.0901 0.0901
Giardia lamblia Cathepsin B precursor 0.0073 0.0133 0.0133
Giardia lamblia Cathepsin B precursor 0.0073 0.0133 0.0133
Schistosoma mansoni nck2/grb4 0.0053 0.0064 0.0049
Loa Loa (eye worm) hypothetical protein 0.0087 0.0184 0.0184
Loa Loa (eye worm) voltage-dependent calcium channel 0.0068 0.0118 0.0118
Brugia malayi PAN domain containing protein 0.0087 0.0184 0.0184
Toxoplasma gondii microneme protein MIC17B 0.0087 0.0184 0.0184
Giardia lamblia Alanyl dipeptidyl peptidase 0.0043 0.003 0.003
Brugia malayi hypothetical protein 0.011 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.1943 0.662 0.662
Echinococcus granulosus BTB:POZ domain containing protein KCTD16 0.0079 0.0155 0.0155
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0069 0.0121 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.0901 0.0873
Toxoplasma gondii microneme protein MIC17C 0.0087 0.0184 0.0184
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0067 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0073 0.0133 0.0133
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0143 0.0376 0.0296
Schistosoma mansoni histone deacetylase 0.0487 0.1568 0.1556
Leishmania major cysteine peptidase A (CPA) 0.0294 0.0901 0.0792
Brugia malayi solute carrier family 40, member 1 0.0323 0.0999 0.0999
Onchocerca volvulus 0.0087 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0055 0.0071 0.0071
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0153 0.0411 0.0382
Trypanosoma cruzi hypothetical protein, conserved 0.0629 0.2064 0.2039
Brugia malayi cathepsin L-like cysteine proteinase 0.0073 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.0901 0.0901
Echinococcus granulosus caspase 2 0.0407 0.1292 0.1292
Brugia malayi protein-tyrosine kinase 0.0056 0.0075 0.0075
Brugia malayi latrophilin 2 splice variant baaae 0.0046 0.004 0.004
Echinococcus granulosus tyrosine protein kinase Fyn 0.0081 0.0161 0.0161
Echinococcus multilocularis potassium voltage gated channel protein 0.0148 0.0393 0.0393
Onchocerca volvulus 0.0053 0.0064 0.0064
Mycobacterium ulcerans hypothetical protein 0.0731 0.2417 1
Brugia malayi K+ channel tetramerisation domain containing protein 0.0079 0.0155 0.0155
Schistosoma mansoni histone deacetylase hda2 0.0267 0.0807 0.0793
Echinococcus multilocularis voltage gated potassium channel 0.0148 0.0393 0.0393
Echinococcus multilocularis fibrillin 1 0.0073 0.0135 0.0135
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0073 0.0133 0.0103
Trypanosoma cruzi cysteine peptidase, putative 0.0163 0.0444 0.0415
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0201 0.0578 0.0549
Plasmodium falciparum serine repeat antigen 8 0.0073 0.0133 0.0103
Plasmodium falciparum eukaryotic initiation factor 4A 0.2917 1 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0064 0.0064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0072 0.0072
Loa Loa (eye worm) fibroinase 0.0294 0.0901 0.0901
Echinococcus granulosus tissue type plasminogen activator 0.0629 0.2064 0.2064
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.1634 0.5548 0.5548
Echinococcus multilocularis histone deacetylase 3 0.0487 0.1568 0.1568
Leishmania major histone deacetylase, putative 0.0487 0.1568 0.1468
Trypanosoma brucei prolyl endopeptidase 0.0123 0.0307 0.0278
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0072 0.0072
Echinococcus granulosus histone deacetylase 0.0488 0.1572 0.1572
Brugia malayi Trypsin family protein 0.0731 0.2417 0.2417
Echinococcus multilocularis BTB:POZ domain containing protein 0.0079 0.0155 0.0155
Echinococcus multilocularis two pore calcium channel protein 1 0.0068 0.0118 0.0118
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.2917 1 1
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0068 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0073 0.0133 0.0133
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0868 0.2893 0.2893
Loa Loa (eye worm) histone deacetylase 1 0.0487 0.1568 0.1568
Giardia lamblia Cathepsin B precursor 0.03 0.0923 0.0923
Onchocerca volvulus 0.0073 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0809 0.2686 0.2686
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.1634 0.5548 0.5548
Echinococcus multilocularis transmembrane protease serine 3 0.0731 0.2417 0.2417
Loa Loa (eye worm) voltage-gated calcium channel 0.0068 0.0118 0.0118
Toxoplasma gondii histone deacetylase HDAC4 0.0267 0.0807 0.0807
Echinococcus granulosus transient receptor potential cation channel 0.0068 0.0118 0.0118
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0068 0.0118 0.0103
Loa Loa (eye worm) hypothetical protein 0.0323 0.0999 0.0999
Giardia lamblia Cathepsin B precursor 0.03 0.0923 0.0923
Onchocerca volvulus Cathepsin L homolog 0.0294 0.0901 0.0901
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.0444 0.0444
Schistosoma mansoni hypothetical protein 0.0187 0.053 0.0516
Trypanosoma brucei histone deacetylase 3 0.0488 0.1572 0.1546
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0148 0.0393 0.0393
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0118
Brugia malayi Histone deacetylase 1 0.0487 0.1568 0.1568
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0163 0.0444 0.043
Echinococcus multilocularis potassium large conductance calcium activated 0.0068 0.0118 0.0118
Echinococcus granulosus cathepsin l1 0.0294 0.0901 0.0901
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0043 0.003 0.003
Brugia malayi SRC-1 0.0081 0.0161 0.0161
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.0133 0.0133
Echinococcus granulosus tyrosine protein kinase ABL1 0.012 0.0296 0.0296
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0026 0.0011
Onchocerca volvulus Deterin homolog 0.1634 0.5548 0.5548
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0068 0.0118 0.0118
Loa Loa (eye worm) PAN domain-containing protein 0.0087 0.0184 0.0184
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0045 0.0038 0.0038
Echinococcus multilocularis potassium voltage gated channel protein 0.0148 0.0393 0.0393
Entamoeba histolytica cysteine protease, putative 0.0294 0.0901 0.0877
Toxoplasma gondii cathepsin CPL 0.0294 0.0901 0.0901
Schistosoma mansoni hypothetical protein 0.0068 0.0118 0.0103
Schistosoma mansoni integrin alpha-ps 0.0391 0.1236 0.1222
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0073 0.0133 0.0118
Echinococcus granulosus integrin alpha ps 0.0187 0.053 0.053
Schistosoma mansoni cathepsin D (A01 family) 0.0042 0.0025 0.0011
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.1737 0.5905 0.5905
Brugia malayi Protein kinase domain containing protein 0.0631 0.2069 0.2069
Leishmania major cathepsin L-like protease 0.0294 0.0901 0.0792
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0079 0.0155 0.0155
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0201 0.0578 0.0549
Brugia malayi Angiotensin-converting enzyme family protein 0.1582 0.537 0.537
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0073 0.0133 0.0103
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0073 0.0133 0.0103
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0068 0.0118 0.0088
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0118
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0073 0.0133 0.0103
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0079 0.0155 0.0126
Plasmodium falciparum histone deacetylase 2 0.0488 0.1572 0.1546
Entamoeba histolytica cysteine protease, putative 0.0163 0.0444 0.0419
Echinococcus multilocularis integrin alpha 3 0.0668 0.2198 0.2198
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0073 0.0133 0.0133
Echinococcus multilocularis cathepsin L cysteine protease 0.0294 0.0901 0.0901
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0068 0.0118 0.0118
Schistosoma mansoni voltage-dependent calcium channel 0.0068 0.0118 0.0103
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0043 0.003 0.003
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0731 0.2417 0.2406
Toxoplasma gondii preprocathepsin c precursor, putative 0.0073 0.0133 0.0133
Echinococcus granulosus voltage gated hydrogen channel 1 0.0068 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0204 0.0589 0.0589
Onchocerca volvulus 0.0204 0.0589 0.0589
Brugia malayi Kelch motif family protein 0.0267 0.0806 0.0806
Schistosoma mansoni integrin alpha-ps 0.0203 0.0586 0.0572
Schistosoma mansoni voltage-gated potassium channel 0.0079 0.0155 0.0141
Loa Loa (eye worm) ion channel NompC 0.0068 0.0118 0.0118
Toxoplasma gondii calcium binding egf domain-containing protein 0.0039 0.0015 0.0015
Onchocerca volvulus 0.0323 0.0999 0.0999
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0118
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0487 0.1568 0.1568
Echinococcus granulosus tyrosine protein kinase Fyn 0.0081 0.0161 0.0161
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0294 0.0901 0.0901
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0081 0.0161 0.0161
Echinococcus multilocularis glycoprotein Antigen 5 0.0731 0.2417 0.2417
Brugia malayi STAT protein, DNA binding domain containing protein 0.0165 0.0453 0.0453
Echinococcus multilocularis acylamino acid releasing enzyme 0.0043 0.003 0.003
Plasmodium vivax histone deacetylase 1, putative 0.0487 0.1568 0.1543
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0148 0.0393 0.0393
Giardia lamblia Cathepsin L-like protease 0.0073 0.0133 0.0133
Brugia malayi Histone deacetylase family protein 0.0488 0.1572 0.1572
Entamoeba histolytica cysteine protease, putative 0.0073 0.0133 0.0107
Brugia malayi Histone deacetylase family protein 0.0488 0.1572 0.1572
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0068 0.0118 0.0118
Schistosoma mansoni voltage-gated potassium channel 0.1816 0.6181 0.6175
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.0901 0.0901
Toxoplasma gondii microneme protein MIC17A 0.0087 0.0184 0.0184
Leishmania major hypothetical protein, conserved 0.0079 0.0155 0.0038
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0073 0.0133 0.0118
Brugia malayi hypothetical protein 0.0068 0.0118 0.0118
Loa Loa (eye worm) integrin beta-2 0.1693 0.5753 0.5753
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0072 0.0057
Brugia malayi ion channel NompC 0.0068 0.0118 0.0118
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0043 0.003 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.0901 0.0901
Onchocerca volvulus 0.0294 0.0901 0.0901
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0294 0.0901 0.0873
Trichomonas vaginalis histone deacetylase, putative 0.0487 0.1568 0.1568
Schistosoma mansoni transient receptor potential channel 0.0068 0.0118 0.0103
Trypanosoma brucei btb/poz domain containing protein, putative 0.0079 0.0155 0.0126
Schistosoma mansoni ryanodine receptor related 0.0068 0.0118 0.0103
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0079 0.0155 0.0126
Trichomonas vaginalis histone deacetylase, putative 0.0487 0.1568 0.1568
Loa Loa (eye worm) hypothetical protein 0.0731 0.2417 0.2417
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0068 0.0118 0.0118
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.2917 1 1
Echinococcus multilocularis transient receptor potential cation channel 0.0068 0.0118 0.0118
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0081 0.0161 0.0161
Giardia lamblia Cathepsin B precursor 0.03 0.0923 0.0923
Echinococcus granulosus voltage gated potassium channel 0.0068 0.0118 0.0118
Brugia malayi Variant SH3 domain containing protein 0.0053 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0118
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0069 0.0121 0.0091
Leishmania major cathepsin L-like protease 0.0294 0.0901 0.0792
Giardia lamblia Cathepsin B precursor 0.0073 0.0133 0.0133
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0153 0.0411 0.0382
Echinococcus granulosus voltage dependent calcium channel 0.0068 0.0118 0.0118
Schistosoma mansoni tyrosine kinase 0.0092 0.0198 0.0183
Entamoeba histolytica cysteine protease, putative 0.0163 0.0444 0.0419
Trypanosoma brucei oligopeptidase b 0.0069 0.0121 0.0091
Entamoeba histolytica hypothetical protein, conserved 0.0043 0.003 0.0004
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0073 0.0133 0.0103
Entamoeba histolytica cysteine proteinase, putative 0.0294 0.0901 0.0877
Entamoeba histolytica cysteine protease, putative 0.0163 0.0444 0.0419
Echinococcus multilocularis cysteine protease 0.0294 0.0901 0.0901
Schistosoma mansoni hypothetical protein 0.0629 0.2064 0.2052
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0073 0.0133 0.0107
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0053 0.0064 0.0049
Loa Loa (eye worm) STAT protein 0.0165 0.0453 0.0453
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0081 0.0161 0.0161
Brugia malayi Transient-receptor-potential like protein 0.0068 0.0118 0.0118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.0901 0.0873
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0068 0.0118 0.0118
Schistosoma mansoni cathepsin B (C01 family) 0.0073 0.0133 0.0118
Onchocerca volvulus 0.0079 0.0155 0.0155
Brugia malayi Integrin alpha cytoplasmic region family protein 0.047 0.1512 0.1512
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.0901 0.0873
Schistosoma mansoni transient receptor potential channel 0.0068 0.0118 0.0103
Echinococcus multilocularis short transient receptor potential channel 6 0.0068 0.0118 0.0118
Echinococcus granulosus growth factor receptor bound protein 2 0.0511 0.1654 0.1654
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0068 0.0118 0.0118
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0153 0.0411 0.0397
Echinococcus granulosus baculoviral IAP repeat containing protein 0.1634 0.5548 0.5548
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0054 0.0069 0.0054
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0068 0.0118 0.0103
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0068 0.0118 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0133 0.0133
Leishmania major cathepsin L-like protease 0.0294 0.0901 0.0792
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0053 0.0064 0.0064
Brugia malayi Trypsin family protein 0.0731 0.2417 0.2417
Schistosoma mansoni voltage-gated potassium channel 0.0068 0.0118 0.0103
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0079 0.0155 0.0155
Brugia malayi cathepsin Z-like cysteine proteinase 0.0073 0.0133 0.0133
Brugia malayi cathepsin L precursor 0.0073 0.0133 0.0133
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0629 0.2064 0.2039
Echinococcus granulosus dihydrofolate reductase 0.0058 0.0082 0.0082
Plasmodium vivax serine-repeat antigen (SERA) 0.0073 0.0133 0.0103
Entamoeba histolytica cysteine protease, putative 0.0163 0.0444 0.0419
Brugia malayi Tyrosine-protein kinase abl-1 0.0089 0.0189 0.0189
Echinococcus granulosus ryanodine receptor 44f 0.0068 0.0118 0.0118
Brugia malayi K+ channel tetramerisation domain containing protein 0.0079 0.0155 0.0155
Echinococcus multilocularis tissue type plasminogen activator 0.0629 0.2064 0.2064
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0073 0.0133 0.0107
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0054 0.0069 0.0069
Echinococcus multilocularis Mastin 0.0731 0.2417 0.2417
Schistosoma mansoni hypothetical protein 0.0042 0.0026 0.0011
Brugia malayi Papain family cysteine protease containing protein 0.0073 0.0133 0.0133
Onchocerca volvulus 0.1212 0.4083 0.4083
Brugia malayi PAN domain containing protein 0.0087 0.0184 0.0184
Brugia malayi Cathepsin L-like precursor 0.0294 0.0901 0.0901
Echinococcus granulosus histone deacetylase 6 0.0488 0.1572 0.1572
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0079 0.0155 0.0126
Trypanosoma cruzi major cysteine proteinase, putative 0.0073 0.0133 0.0103
Onchocerca volvulus 0.0294 0.0901 0.0901
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0068 0.0118 0.0118
Schistosoma mansoni cercarial elastase (S01 family) 0.0731 0.2417 0.2406
Brugia malayi Papain family cysteine protease containing protein 0.0163 0.0444 0.0444
Brugia malayi histone deacetylase 1 (HD1) 0.0487 0.1568 0.1568
Trichomonas vaginalis histone deacetylase, putative 0.0487 0.1568 0.1568
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0079 0.0155 0.0126
Brugia malayi Papain family cysteine protease containing protein 0.0073 0.0133 0.0133
Brugia malayi Variant SH3 domain containing protein 0.0053 0.0064 0.0064
Schistosoma mansoni voltage-gated potassium channel 0.0068 0.0118 0.0103
Toxoplasma gondii cathepsin CPC2 0.0073 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0048 0.0048 0.0048
Echinococcus granulosus cathepsin b 0.0809 0.2686 0.2686
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0148 0.0393 0.0393
Loa Loa (eye worm) hypothetical protein 0.0294 0.0901 0.0901
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0068 0.0118 0.0118
Schistosoma mansoni cercarial elastase (S01 family) 0.0731 0.2417 0.2406
Trichomonas vaginalis histone deacetylase, putative 0.0487 0.1568 0.1568
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0073 0.0133 0.0118
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0068 0.0118 0.0118
Loa Loa (eye worm) cysteine protease 0.0294 0.0901 0.0901
Onchocerca volvulus 0.0143 0.0376 0.0376
Schistosoma mansoni growth factor receptor-bound protein 0.0511 0.1654 0.1642
Echinococcus multilocularis tyrosine protein kinase ABL1 0.012 0.0296 0.0296
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0073 0.0133 0.0133
Loa Loa (eye worm) prolyl oligopeptidase 0.0043 0.003 0.003
Brugia malayi Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog 0.0079 0.0155 0.0155
Giardia lamblia Cathepsin L precursor 0.0073 0.0133 0.0133
Leishmania major cathepsin L-like protease 0.0294 0.0901 0.0792
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.0901 0.0873
Echinococcus multilocularis potassium voltage gated channel protein 0.1816 0.6181 0.6181
Echinococcus multilocularis hyperpolarization activated cyclic 0.0068 0.0118 0.0118
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0026 0.0026
Echinococcus granulosus short transient receptor potential channel 6 0.0068 0.0118 0.0118
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0731 0.2417 0.2406
Schistosoma mansoni cercarial elastase (S01 family) 0.0731 0.2417 0.2406
Loa Loa (eye worm) hypothetical protein 0.0148 0.0393 0.0393
Loa Loa (eye worm) PAN domain-containing protein 0.0087 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0123 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0087 0.0184 0.0184
Echinococcus granulosus tyrosine protein kinase Blk 0.0056 0.0075 0.0075
Echinococcus multilocularis voltage dependent calcium channel 0.0068 0.0118 0.0118
Brugia malayi SEA domain containing protein 0.0053 0.0064 0.0064
Echinococcus granulosus cathepsin l cysteine peptidase 0.0294 0.0901 0.0901
Loa Loa (eye worm) hypothetical protein 0.0036 0.0005 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.0901 0.0873
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0068 0.0118 0.0118
Toxoplasma gondii PAN domain-containing protein 0.0087 0.0184 0.0184
Echinococcus multilocularis BTB:POZ domain containing protein KCTD16 0.0079 0.0155 0.0155
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0043 0.003 0.0004
Trypanosoma cruzi oligopeptidase b 0.0069 0.0121 0.0091
Schistosoma mansoni voltage-gated cation channel 0.0068 0.0118 0.0103
Echinococcus granulosus transient receptor potential cation channel 0.0068 0.0118 0.0118
Trypanosoma cruzi cysteine peptidase, putative 0.0294 0.0901 0.0873
Echinococcus granulosus transient receptor potential cation channel 0.0068 0.0118 0.0118
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0079 0.0155 0.0126
Schistosoma mansoni histone deacetylase 0.0487 0.1568 0.1556
Onchocerca volvulus Cathepsin L homolog 0.0294 0.0901 0.0901
Onchocerca volvulus 0.0053 0.0064 0.0064
Trypanosoma brucei BTB/POZ domain/Regulator of chromosome condensation (RCC1) repeat, putative 0.0079 0.0155 0.0126
Toxoplasma gondii subtilisin SUB12 0.0105 0.0243 0.0243
Trypanosoma brucei btb/poz domain containing protein, putative 0.0079 0.0155 0.0126
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0487 0.1568 0.1568
Entamoeba histolytica hypothetical protein 0.0073 0.0133 0.0107
Onchocerca volvulus 0.0079 0.0155 0.0155
Echinococcus granulosus glycoprotein Antigen 5 0.0731 0.2417 0.2417
Loa Loa (eye worm) hypothetical protein 0.011 0.0261 0.0261
Loa Loa (eye worm) DOMON domain-containing protein 0.0053 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0481 0.1548 0.1548
Loa Loa (eye worm) PAN domain-containing protein 0.0087 0.0184 0.0184
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0081 0.0161 0.0161
Toxoplasma gondii kelch repeat and K+ channel tetramerisation domain containing protein 0.0079 0.0155 0.0155
Echinococcus granulosus sodium leak channel non selective protein 0.0068 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0118
Brugia malayi Kringle domain containing protein 0.0629 0.2064 0.2064
Toxoplasma gondii PAN/Apple domain-containing protein 0.0087 0.0184 0.0184
Toxoplasma gondii histone deacetylase HDAC3 0.0487 0.1568 0.1568
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0201 0.0578 0.0465
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0118
Brugia malayi Papain family cysteine protease containing protein 0.0163 0.0444 0.0444
Loa Loa (eye worm) hypothetical protein 0.2917 1 1
Loa Loa (eye worm) hypothetical protein 0.026 0.0784 0.0784
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0081 0.0161 0.0161
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0068 0.0118 0.0118
Schistosoma mansoni voltage-gated potassium channel 0.0068 0.0118 0.0103
Plasmodium falciparum histone deacetylase 1 0.0487 0.1568 0.1543
Trypanosoma cruzi histone deacetylase 1, putative 0.0487 0.1568 0.1543
Onchocerca volvulus 0.0079 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0043 0.003 0.003
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0073 0.0133 0.0103
Loa Loa (eye worm) hypothetical protein 0.0204 0.0589 0.0589
Loa Loa (eye worm) hypothetical protein 0.0073 0.0133 0.0133
Onchocerca volvulus 0.0079 0.0155 0.0155
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0043 0.003 0.003
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.2917 1 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0163 0.0444 0.0419
Brugia malayi histone deacetylase 3 (HD3) 0.0487 0.1568 0.1568
Trypanosoma cruzi potassium voltage-gated channel 0.0079 0.0155 0.0126
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0073 0.0133 0.0133
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.03 0.0923 0.0814
Trypanosoma cruzi cysteine proteinase, putative 0.0163 0.0444 0.0415
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0133 0.0133
Echinococcus granulosus hyperpolarization activated cyclic 0.0068 0.0118 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0116 0.0116
Toxoplasma gondii hypothetical protein 0.0043 0.003 0.003
Brugia malayi thymidylate synthase 0.0143 0.0376 0.0376
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0148 0.0393 0.0393
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0118
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0043 0.003 0.0015
Giardia lamblia Cathepsin L precursor 0.0073 0.0133 0.0133
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0068 0.0118 0.0118
Toxoplasma gondii PAN domain-containing protein 0.0087 0.0184 0.0184
Echinococcus granulosus histone deacetylase 6 0.0488 0.1572 0.1572
Brugia malayi hypothetical protein 0.0731 0.2417 0.2417
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0045 0.0038 0.0038
Entamoeba histolytica cysteine protease, putative 0.0073 0.0133 0.0107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.0901 0.0873
Brugia malayi K+ channel tetramerisation domain containing protein 0.0079 0.0155 0.0155
Echinococcus granulosus enteropeptidase 0.0731 0.2417 0.2417
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0048 0.0048 0.0048
Brugia malayi PAN domain containing protein 0.0087 0.0184 0.0184
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0073 0.0133 0.0103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0072 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.0901 0.0901
Schistosoma mansoni potassium channel tetramerization domain-containing 0.0079 0.0155 0.0141
Loa Loa (eye worm) TK/ROR protein kinase 0.0631 0.2069 0.2069
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0068 0.0118 0.0118
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0072 0.0072
Echinococcus multilocularis apoptotic protease activating factor 1 0.0407 0.1292 0.1292
Echinococcus multilocularis c src tyrosine kinase 0.0054 0.0069 0.0069
Giardia lamblia Cathepsin L precursor 0.0073 0.0133 0.0133
Leishmania major histone deacetylase, putative 0.0487 0.1568 0.1468
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.0296 0.0906 0.0893
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0118
Onchocerca volvulus 0.0731 0.2417 0.2417
Entamoeba histolytica cysteine proteinase, putative 0.0294 0.0901 0.0877
Brugia malayi cathepsin F-like cysteine proteinase 0.0073 0.0133 0.0133
Entamoeba histolytica cysteine protease, putative 0.0163 0.0444 0.0419
Giardia lamblia Alanyl dipeptidyl peptidase 0.0043 0.003 0.003
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0073 0.0133 0.0133
Loa Loa (eye worm) histone deacetylase 11 0.0267 0.0807 0.0807
Echinococcus granulosus histone deacetylase 1 0.0487 0.1568 0.1568
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0068 0.0118 0.0118
Echinococcus multilocularis cathepsin b 0.0809 0.2686 0.2686
Schistosoma mansoni voltage-gated ion channel 0.0068 0.0118 0.0103
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.2917 1 1
Leishmania major cathepsin L-like protease 0.0294 0.0901 0.0792
Onchocerca volvulus 0.0294 0.0901 0.0901
Onchocerca volvulus 0.0294 0.0901 0.0901
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0738 0.244 0.2428
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0073 0.0133 0.0133
Echinococcus granulosus histone deacetylase 8 0.0267 0.0807 0.0807
Plasmodium falciparum serine repeat antigen 9 0.0073 0.0133 0.0103
Echinococcus multilocularis tyrosine protein kinase Abl 0.0089 0.0189 0.0189
Schistosoma mansoni histone deacetylase 4 5 0.0488 0.1572 0.1559
Trypanosoma cruzi cruzipain precursor, putative 0.009 0.0191 0.0162
Leishmania major histone deacetylase, putative 0.0488 0.1572 0.1472
Brugia malayi Calcitonin receptor-like protein seb-1 0.0067 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0091 0.0197 0.0197
Onchocerca volvulus 0.0053 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0046 0.004 0.0025
Loa Loa (eye worm) hypothetical protein 0.0046 0.004 0.004
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0153 0.0411 0.0382
Onchocerca volvulus 0.0087 0.0184 0.0184
Loa Loa (eye worm) TK/ABL protein kinase 0.012 0.0296 0.0296
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0554 0.1801 0.1788
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0073 0.0133 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.009 0.0191 0.0191
Brugia malayi olfactory channel protein osm-9 0.0068 0.0118 0.0118
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0068 0.0118 0.0103
Giardia lamblia Hypothetical protein 0.0073 0.0133 0.0133
Echinococcus granulosus TRP transient receptor potential channel 0.0068 0.0118 0.0118
Leishmania major eukaryotic initiation factor 4a, putative 0.2917 1 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0068 0.0118 0.0118
Plasmodium falciparum cysteine proteinase falcipain 3 0.0294 0.0901 0.0873
Brugia malayi Cathepsin L-like precursor 0.009 0.0191 0.0191
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0148 0.0393 0.0393
Echinococcus granulosus tumor protein p63 0.0232 0.0684 0.0684
Entamoeba histolytica cysteine protease, putative 0.0163 0.0444 0.0419
Echinococcus granulosus tyrosine protein kinase Src42A 0.0081 0.0161 0.0161
Toxoplasma gondii transporter, cation channel family protein 0.0068 0.0118 0.0118
Echinococcus multilocularis cathepsin L 0.0073 0.0133 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.0901 0.0901
Loa Loa (eye worm) calcium channel 0.0068 0.0118 0.0118
Brugia malayi prolyl oligopeptidase family protein 0.0043 0.003 0.003
Leishmania major potassium voltage-gated channel, putative 0.0079 0.0155 0.0038
Brugia malayi Trypsin family protein 0.1943 0.662 0.662
Plasmodium falciparum histone deacetylase, putative 0.0488 0.1572 0.1546
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0153 0.0411 0.0297
Loa Loa (eye worm) trypsin family protein 0.0731 0.2417 0.2417
Schistosoma mansoni cathepsin F (C01 family) 0.0294 0.0901 0.0887
Entamoeba histolytica prolyl oligopeptidase family protein 0.0043 0.003 0.0004
Brugia malayi cathepsin L-like precursor 0.0204 0.0589 0.0589
Brugia malayi prolyl oligopeptidase family protein 0.0123 0.0307 0.0307
Brugia malayi histone deacetylase 11 0.0267 0.0807 0.0807
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0133 0.0133
Trypanosoma brucei btb/poz domain containing protein, putative 0.0079 0.0155 0.0126
Entamoeba histolytica cysteine protease, putative 0.0163 0.0444 0.0419
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0294 0.0901 0.0901
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0068 0.0118 0.0118
Entamoeba histolytica cysteine protease, putative 0.0163 0.0444 0.0419
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0078 0.015 0.015
Schistosoma mansoni tyrosine kinase 0.0054 0.0069 0.0054
Brugia malayi Cell death protein 3 precursor 0.0407 0.1292 0.1292
Schistosoma mansoni transient receptor potential channel 4 0.0068 0.0118 0.0103
Brugia malayi Dihydrofolate reductase 0.0058 0.0082 0.0082
Echinococcus multilocularis shaker cognate 0.0148 0.0393 0.0393
Leishmania major hypothetical protein, conserved 0.0629 0.2064 0.1969
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0056 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.022 0.0645 0.0645
Trypanosoma cruzi histone deacetylase, putative 0.0488 0.1572 0.1546
Loa Loa (eye worm) hypothetical protein 0.0487 0.1568 0.1568
Schistosoma mansoni voltage-gated potassium channel 0.0148 0.0393 0.0379
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0068 0.0118 0.0103
Schistosoma mansoni caspase-7 (C14 family) 0.0407 0.1292 0.1279
Leishmania major hypothetical protein, conserved 0.0079 0.0155 0.0038
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0068 0.0118 0.0118
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0294 0.0901 0.0901
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0143 0.0376 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0073 0.0133 0.0118
Entamoeba histolytica cysteine protease, putative 0.0163 0.0444 0.0419
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0073 0.0133 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0073 0.0133 0.0133
Giardia lamblia Cathepsin L-like protease 0.0073 0.0133 0.0133
Brugia malayi hypothetical protein 0.026 0.0784 0.0784
Echinococcus granulosus Tolloid protein 1 0.0045 0.0038 0.0038
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0294 0.0901 0.0873
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.1816 0.6181 0.6181
Brugia malayi PAN domain containing protein 0.0087 0.0184 0.0184
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0079 0.0155 0.0126
Schistosoma mansoni voltage-gated potassium channel 0.0079 0.0155 0.0141
Schistosoma mansoni growth factor receptor-bound protein 0.0511 0.1654 0.1642
Echinococcus multilocularis prolyl endopeptidase 0.0123 0.0307 0.0307
Brugia malayi Cathepsin L-like precursor 0.0294 0.0901 0.0901
Toxoplasma gondii K+ channel tetramerisation domain-containing protein 0.0079 0.0155 0.0155
Trypanosoma cruzi cruzipain precursor, putative 0.0294 0.0901 0.0873
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0118
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0073 0.0133 0.0103
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0091 0.0197 0.0197
Toxoplasma gondii prolyl endopeptidase 0.0123 0.0307 0.0307
Brugia malayi PAN domain containing protein 0.0087 0.0184 0.0184
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0069 0.0121 0.0091
Giardia lamblia Cathepsin L precursor 0.0073 0.0133 0.0133
Brugia malayi Cathepsin L-like precursor 0.0294 0.0901 0.0901
Onchocerca volvulus 0.0294 0.0901 0.0901
Loa Loa (eye worm) hypothetical protein 0.0267 0.0807 0.0807
Loa Loa (eye worm) hypothetical protein 0.0087 0.0184 0.0184
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0731 0.2417 0.2417
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.2917 1 1
Entamoeba histolytica cysteine protease, putative 0.0073 0.0133 0.0107
Echinococcus granulosus inhibitor of apoptosis protein 0.1634 0.5548 0.5548
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.2917 1 1
Loa Loa (eye worm) hypothetical protein 0.0731 0.2417 0.2417
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0294 0.0901 0.0873
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0163 0.0444 0.043
Brugia malayi fibroinase precursor 0.0073 0.0133 0.0133
Schistosoma mansoni cathepsin F (C01 family) 0.0294 0.0901 0.0887
Echinococcus multilocularis histone deacetylase 7 0.0488 0.1572 0.1572
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0437 0.1395 0.1395
Trypanosoma brucei histone deacetylase 2 0.0267 0.0807 0.0779
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0068 0.0118 0.0118
Plasmodium falciparum serine repeat antigen 7 0.0073 0.0133 0.0103
Loa Loa (eye worm) hypothetical protein 0.0078 0.0149 0.0149
Echinococcus multilocularis cathepsin b 0.0809 0.2686 0.2686
Echinococcus granulosus cathepsin L 0.0163 0.0444 0.0444
Echinococcus multilocularis inhibitor of apoptosis protein 0.1634 0.5548 0.5548
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0267 0.0806 0.0806
Leishmania major cathepsin L-like protease 0.0294 0.0901 0.0792
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0068 0.0118 0.0088
Loa Loa (eye worm) hypothetical protein 0.0068 0.0118 0.0118
Plasmodium vivax unspecified product 0.009 0.0191 0.0162
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0068 0.0118 0.0118
Entamoeba histolytica cysteine proteinase, putative 0.0204 0.0589 0.0565
Echinococcus multilocularis short transient receptor potential channel 6 0.0068 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0244 0.0728 0.0728
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0073 0.0133 0.0103
Echinococcus granulosus thymidylate synthase 0.0143 0.0376 0.0376
Brugia malayi prolyl oligopeptidase family protein 0.0437 0.1395 0.1395
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0143 0.0376 0.0361
Schistosoma mansoni voltage-gated potassium channel 0.1816 0.6181 0.6175
Schistosoma mansoni inhibitor of apoptosis protein 0.1634 0.5548 0.5542
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0294 0.0901 0.0901
Onchocerca volvulus Cathepsin L homolog 0.0073 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0731 0.2417 0.2417
Echinococcus granulosus integrin alpha 3 0.0668 0.2198 0.2198
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0045 0.0038 0.0023
Trypanosoma cruzi histone deacetylase, putative 0.0267 0.0807 0.0779
Echinococcus multilocularis cathepsin L cysteine protease 0.0294 0.0901 0.0901
Trypanosoma cruzi cysteine peptidase, putative 0.0294 0.0901 0.0873
Entamoeba histolytica cysteine protease, putative 0.0073 0.0133 0.0107
Echinococcus granulosus sodium channel protein 0.0068 0.0118 0.0118
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0204 0.0589 0.0561
Schistosoma mansoni tyrosine kinase 0.0081 0.0161 0.0147
Echinococcus granulosus transient receptor potential cation channel 0.0068 0.0118 0.0118
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0068 0.0118 0.0118
Brugia malayi Calcium binding EGF domain containing protein 0.0039 0.0015 0.0015
Echinococcus multilocularis hyperpolarization activated cyclic 0.0068 0.0118 0.0118
Echinococcus granulosus tyrosine protein kinase Fyn 0.0081 0.0161 0.0161
Trichomonas vaginalis histone deacetylase, putative 0.0487 0.1568 0.1568
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0437 0.1395 0.1395
Brugia malayi Cyclic-nucleotide gated cation channel 0.0068 0.0118 0.0118
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.009 0.0191 0.0191
Plasmodium falciparum serine repeat antigen 5 0.0073 0.0133 0.0103
Loa Loa (eye worm) PAN domain-containing protein 0.0087 0.0184 0.0184
Echinococcus granulosus two pore calcium channel protein 1 0.0068 0.0118 0.0118
Loa Loa (eye worm) potassium channel tetramerisation domain containing 5 0.0079 0.0155 0.0155
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0294 0.0901 0.0901
Entamoeba histolytica cysteine protease, putative 0.0073 0.0133 0.0107
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.2917 1 1
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0437 0.1395 0.1395
Brugia malayi cation channel family protein 0.0068 0.0118 0.0118
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0055 0.007 0.007
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0068 0.0118 0.0118
Onchocerca volvulus Arrow homolog 0.0048 0.0048 0.0048
Giardia lamblia Cysteine protease 0.0073 0.0133 0.0133
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0068 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.047 0.1512 0.1512
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0118 0.0118
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0068 0.0118 0.0118
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0069 0.0121 0.1315
Echinococcus granulosus histone deacetylase 6 0.0512 0.1655 0.1655
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0072 0.0072
Brugia malayi Cathepsin L-like precursor 0.0204 0.0589 0.0589
Giardia lamblia Cathepsin B precursor 0.0073 0.0133 0.0133
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0207 0.0599 0.0599
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1959 0.6676 0.6671
Loa Loa (eye worm) cathepsin B 0.03 0.0923 0.0923
Echinococcus granulosus transient receptor potential cation channel 0.0068 0.0118 0.0118
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0068 0.0118 0.0088
Leishmania major cathepsin L-like protease 0.0294 0.0901 0.0792
Echinococcus multilocularis conserved hypothetical protein 0.0068 0.0118 0.0118
Loa Loa (eye worm) PAN domain-containing protein 0.0087 0.0184 0.0184
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0068 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.1634 0.5548 0.5548
Schistosoma mansoni 60S ribosomal protein L21 0.0068 0.0118 0.0103
Brugia malayi Trypsin family protein 0.0731 0.2417 0.2417
Trypanosoma cruzi histone deacetylase 1, putative 0.0487 0.1568 0.1543
Echinococcus granulosus tyrosine kinase 0.0056 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0087 0.0184 0.0184
Brugia malayi Integrin beta pat-3 precursor 0.1693 0.5753 0.5753
Loa Loa (eye worm) hypothetical protein 0.0731 0.2417 0.2417
Brugia malayi Cathepsin L-like cysteine proteinase 0.0204 0.0589 0.0589
Plasmodium vivax vivapain-2 0.0294 0.0901 0.0873
Echinococcus granulosus integrin alpha ps 0.0391 0.1236 0.1236
Loa Loa (eye worm) hypothetical protein 0.0043 0.003 0.003
Leishmania major oligopeptidase b 0.0069 0.0121 0.0003
Brugia malayi Cathepsin L-like precursor 0.0294 0.0901 0.0901
Onchocerca volvulus 0.0731 0.2417 0.2417
Onchocerca volvulus 0.0087 0.0184 0.0184
Toxoplasma gondii cathepsin CPC1 0.0073 0.0133 0.0133
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0068 0.0118 0.0103
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0081 0.0161 0.0161
Schistosoma mansoni cercarial elastase (S01 family) 0.0731 0.2417 0.2406
Schistosoma mansoni cercarial elastase (S01 family) 0.0731 0.2417 0.2406
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0043 0.003 0.0015
Plasmodium vivax RNA helicase-1, putative 0.2917 1 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0068 0.0118 0.0103
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0153 0.0411 0.0411
Schistosoma mansoni cathepsin D (A01 family) 0.0042 0.0025 0.0011
Brugia malayi dihydrofolate reductase family protein 0.0058 0.0082 0.0082
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0073 0.0133 0.0103
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0511 0.1654 0.1654
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0294 0.0901 0.0901
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0068 0.0116 0.0086
Echinococcus multilocularis histone deacetylase 6 0.0488 0.1572 0.1572
Loa Loa (eye worm) papain family cysteine protease containing protein 0.009 0.0191 0.0191
Schistosoma mansoni voltage-gated potassium channel 0.0148 0.0393 0.0379
Plasmodium vivax histone deacetylase 2, putative 0.0488 0.1572 0.1546

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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