Detailed information for compound 1497407

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 409.564 | Formula: C23H23NO2S2
  • H donors: 2 H acceptors: 2 LogP: 2.47 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc(cc1)C(c1ccccc1)(c1ccccc1)SC[C@@H](C(=O)O)N
  • InChi: 1S/C23H23NO2S2/c1-27-20-14-12-19(13-15-20)23(17-8-4-2-5-9-17,18-10-6-3-7-11-18)28-16-21(24)22(25)26/h2-15,21H,16,24H2,1H3,(H,25,26)/t21-/m0/s1
  • InChiKey: GHASTEVBLRFHJB-NRFANRHFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens kinesin family member 11 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Giardia lamblia Kinesin-5 Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium vivax kinesin-5 Get druggable targets OG5_128460 All targets in OG5_128460
Loa Loa (eye worm) kinesin-like protein KLP2 Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium falciparum kinesin-5 Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium yoelii Kinesin motor domain, putative Get druggable targets OG5_128460 All targets in OG5_128460
Schistosoma mansoni kinesin eg-5 Get druggable targets OG5_128460 All targets in OG5_128460
Cryptosporidium hominis kinesin-like boursin Get druggable targets OG5_128460 All targets in OG5_128460
Echinococcus granulosus kinesin family 1 Get druggable targets OG5_128460 All targets in OG5_128460
Candida albicans kinesin motor domain protein similar to S. cerevisiae KIP1 (YBL063W) microtubule motor complex protein Get druggable targets OG5_128460 All targets in OG5_128460
Entamoeba histolytica kinesin, putative Get druggable targets OG5_128460 All targets in OG5_128460
Brugia malayi Kinesin motor domain containing protein Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium berghei kinesin-5, putative Get druggable targets OG5_128460 All targets in OG5_128460
Candida albicans kinesin motor domain protein similar to S. cerevisiae KIP1 (YBL063W) microtubule motor complex protein Get druggable targets OG5_128460 All targets in OG5_128460
Echinococcus multilocularis kinesin family 1 Get druggable targets OG5_128460 All targets in OG5_128460
Cryptosporidium parvum kinesin-like boursin, putative Get druggable targets OG5_128460 All targets in OG5_128460
Schistosoma japonicum ko:K10398 kinesin family member 11, putative Get druggable targets OG5_128460 All targets in OG5_128460
Toxoplasma gondii kinesin motor domain-containing protein Get druggable targets OG5_128460 All targets in OG5_128460
Neospora caninum hypothetical protein Get druggable targets OG5_128460 All targets in OG5_128460
Plasmodium knowlesi kinesin-5, putative Get druggable targets OG5_128460 All targets in OG5_128460
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0739 0.1048
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0134 0.0152
Entamoeba histolytica hypothetical protein 0.0025 0.0359 0.0297
Onchocerca volvulus 0.0021 0.025 0.0315
Loa Loa (eye worm) hypothetical protein 0.0033 0.0551 0.0583
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0551 0.0625
Leishmania major cytochrome p450-like protein 0.0015 0.0085 0.0283
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0359 0.0479
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0295 0.3859
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0134 0.0152
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0064 0.0154
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0739 0.1048
Schistosoma mansoni hypothetical protein 0.0017 0.0133 0.0151
Brugia malayi isocitrate dehydrogenase 0.0017 0.0134 0.012
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.1627 0.1572
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.1146 0.1261
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0739 0.1048
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0085 0.0051
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.025 0.2788
Brugia malayi Kinesin motor domain containing protein 0.0032 0.0541 0.0824
Brugia malayi Cytochrome P450 family protein 0.0057 0.1219 0.1996
Brugia malayi MH2 domain containing protein 0.013 0.3213 0.5441
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.025 0.2857
Schistosoma mansoni hypothetical protein 0.0017 0.0133 0.0151
Onchocerca volvulus 0.0033 0.0551 0.0767
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0295 0.0291
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.025 0.0284
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0413 0.6694
Mycobacterium leprae Conserved hypothetical protein 0.0015 0.0085 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0739 0.1048
Brugia malayi Pre-SET motif family protein 0.0033 0.0551 0.0842
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0134 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0133 0.0106
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0551 0.7136
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0085 0.0051
Brugia malayi PAS domain containing protein 0.0053 0.111 0.1807
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.025 0.0284
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.025 0.0284
Schistosoma mansoni hypothetical protein 0.0017 0.0133 0.0151
Toxoplasma gondii kinesin motor domain-containing protein 0.0032 0.0541 0.6981
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0128 0.317 0.3596
Loa Loa (eye worm) hypothetical protein 0.0035 0.0616 0.0656
Schistosoma mansoni hypothetical protein 0.0185 0.4702 0.5333
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0677 0.1059
Schistosoma mansoni alpha-glucosidase 0.0153 0.3833 0.4348
Schistosoma mansoni hypothetical protein 0.0215 0.5541 0.6285
Loa Loa (eye worm) hypothetical protein 0.0021 0.025 0.024
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0133 0.0106
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.004 0.0045
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0861 0.0977
Giardia lamblia Kinesin-5 0.0032 0.0541 0.0254
Echinococcus granulosus geminin 0.0185 0.4702 0.5333
Loa Loa (eye worm) hypothetical protein 0.0031 0.0521 0.0549
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.025 0.0284
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0134 0.0152
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.1627 0.1845
Brugia malayi Doublecortin family protein 0.0021 0.025 0.0321
Leishmania major protein kinase, putative 0.0019 0.0185 0.0913
Entamoeba histolytica kinesin, putative 0.0032 0.0541 0.048
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0064 0.0037
Schistosoma mansoni ran 0.0023 0.0295 0.0334
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0413 0.2234
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0227 0.5852 0.6622
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0519 0.0588
Brugia malayi RNA, U transporter 1 0.0089 0.2102 0.3521
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0551 0.0625
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0295 0.3212
Schistosoma mansoni rab6-interacting 0.0021 0.025 0.0284
Echinococcus multilocularis lysosomal alpha glucosidase 0.0177 0.4508 0.5113
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.1219 0.1344
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0413 0.686
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.0064 0.0037
Brugia malayi Pre-SET motif family protein 0.0227 0.5852 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0413 0.2354
Schistosoma mansoni hypothetical protein 0.0017 0.0133 0.0151
Brugia malayi hypothetical protein 0.0178 0.4516 0.7693
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0133 0.0151
Loa Loa (eye worm) hypoxia-induced factor 1 0.0164 0.414 0.4672
Schistosoma mansoni hypothetical protein 0.0056 0.1202 0.1363
Echinococcus granulosus GPCR family 2 0.0017 0.0133 0.0151
Loa Loa (eye worm) hypothetical protein 0.0021 0.025 0.024
Echinococcus multilocularis RUN 0.0021 0.025 0.0284
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0688 0.0973
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0133 0.0151
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0133 0.0119
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.025 0.0284
Brugia malayi hypothetical protein 0.0021 0.025 0.0321
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0133 0.0119
Plasmodium vivax kinesin-5 0.0032 0.0541 0.9758
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0295 0.1476
Plasmodium vivax importin-beta 2, putative 0.0031 0.0521 0.9276
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0085 0.0283
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0551 0.0625
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.08 0.0907
Echinococcus multilocularis GPCR, family 2 0.0017 0.0133 0.0151
Loa Loa (eye worm) doublecortin family protein 0.0021 0.025 0.024
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0739 0.0838
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0861 0.0977
Brugia malayi Cytochrome P450 family protein 0.0015 0.0085 0.0035
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0739 0.1048
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0064 0.0154
Schistosoma mansoni kinesin eg-5 0.0032 0.0541 0.0614
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0739 0.1048
Loa Loa (eye worm) kinesin-like protein KLP2 0.0032 0.0541 0.0571
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.1627 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0739 0.1048
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0133 0.0151
Schistosoma mansoni importin beta-1 0.0031 0.0521 0.0591
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0295 0.0398
Schistosoma mansoni alpha glucosidase 0.0039 0.0739 0.0838
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0739 0.1048
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0064 0.0154
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0085 0.0096
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0134 0.0591
Leishmania major cytochrome p450-like protein 0.0015 0.0085 0.0283
Brugia malayi hypothetical protein 0.0027 0.0413 0.0603
Echinococcus granulosus importin subunit beta 1 0.0031 0.0521 0.0591
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0413 0.2354
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0521 0.0591
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.025 0.0284
Schistosoma mansoni ran 0.0023 0.0295 0.0334
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0761 0.1203
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0134 0.0591
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0085 0.0283
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.1627 0.2699
Echinococcus granulosus lysosomal alpha glucosidase 0.0177 0.4508 0.5113
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0734 1
Entamoeba histolytica Ran family GTPase 0.0023 0.0295 0.0232
Giardia lamblia DNA repair protein RAD52 0.0379 1 1
Brugia malayi Cytochrome P450 family protein 0.0015 0.0085 0.0035
Brugia malayi Glycosyl hydrolases family 31 protein 0.0177 0.4508 0.7678
Mycobacterium leprae putative cytochrome p450 0.0015 0.0085 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.1627 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0739 0.0679
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0295 0.1607
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0734 0.0833
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0551 0.0625
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0133 0.0151
Trichomonas vaginalis set domain proteins, putative 0.0258 0.6707 1
Loa Loa (eye worm) hypothetical protein 0.0178 0.4516 0.5101
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0134 0.0152
Schistosoma mansoni loxhd1 0.0021 0.025 0.0284
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.1146 0.1869
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0085 0.0283
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0015 0.0085 0.0283
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0413 0.5024
Plasmodium vivax SET domain protein, putative 0.0033 0.0551 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0064 0.0037
Schistosoma mansoni lipoxygenase 0.0128 0.317 0.3596
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0064 0.0037
Onchocerca volvulus 0.0039 0.0734 0.1042
Loa Loa (eye worm) hypothetical protein 0.0054 0.1146 0.1261
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0295 0.0334
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0413 0.686
Echinococcus multilocularis geminin 0.0185 0.4702 0.5333
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0134 0.0107
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0739 0.4405
Schistosoma mansoni lipoxygenase 0.009 0.2115 0.2399
Plasmodium falciparum importin beta, putative 0.0031 0.0521 0.9507
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0739 1
Brugia malayi hypothetical protein 0.0018 0.0148 0.0144
Leishmania major importin beta-1 subunit, putative 0.0025 0.0359 0.2012
Schistosoma mansoni cytochrome P450 0.0015 0.0085 0.0096
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0134 0.0747
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0359 0.2012
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0064 0.0037
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.004 0.0045
Schistosoma mansoni hypothetical protein 0.0021 0.025 0.0284
Trypanosoma brucei glucosidase, putative 0.0039 0.0739 0.4318
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0295 0.1607
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0134 0.012
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0521 0.2925
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0739 0.1166
Loa Loa (eye worm) hypothetical protein 0.0015 0.0064 0.0028
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0688 0.0973
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0739 0.4405
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0739 0.1048
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0085 0.0283
Schistosoma mansoni hypothetical protein 0.0037 0.0677 0.0768
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0134 0.0152
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0521 0.2925
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0551 0.0625
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0359 0.0479
Leishmania major GTP-binding protein, putative 0.0023 0.0295 0.1607
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0739 0.4405
Schistosoma mansoni alpha-glucosidase 0.0153 0.3833 0.4348
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.1146 0.1869
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0739 0.0838
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0134 0.0444
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0739 0.0679
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0295 0.3955
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0739 0.0796
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.004 0.0045
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.3213 0.3616
Echinococcus granulosus RUN 0.0021 0.025 0.0284
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0064 0.0037
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0.004 0.5
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0134 0.0152
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0134 0.0591
Leishmania major cytochrome p450-like protein 0.0015 0.0085 0.0283
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0064 0.0037
Brugia malayi cytochrome P450 0.0015 0.0085 0.0035
Brugia malayi hypothetical protein 0.0021 0.025 0.0321
Plasmodium falciparum kinesin-5 0.0032 0.0541 1
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0521 0.6673
Echinococcus multilocularis snurportin 1 0.0335 0.8816 1
Echinococcus granulosus transcription factor Dp 1 0.0042 0.08 0.0907
Schistosoma mansoni hypothetical protein 0.0015 0.0085 0.0096
Echinococcus granulosus kinesin family 1 0.0247 0.6418 0.728
Echinococcus granulosus snurportin 1 0.0335 0.8816 1
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0134 0.0747
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0064 0.0037
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0551 0.0625
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0085 0.0051
Echinococcus multilocularis kinesin family 1 0.0247 0.6418 0.728
Leishmania major hypothetical protein, conserved 0.0027 0.0413 0.2354
Schistosoma mansoni hypothetical protein 0.0185 0.4702 0.5333
Schistosoma mansoni polycystin 1-related 0.0021 0.025 0.0284
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0734 0.1158
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0335 0.8816 1
Onchocerca volvulus 0.0103 0.2466 0.3639
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.1627 1
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0085 0.0283
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0128 0.317 0.3596
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0295 0.0334
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.1627 0.1845
Schistosoma mansoni hypothetical protein 0.0335 0.8816 1
Entamoeba histolytica hypothetical protein 0.0108 0.2605 0.2557
Brugia malayi hypoxia-induced factor 1 0.0164 0.414 0.7043
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0085 0.0131
Onchocerca volvulus 0.0021 0.025 0.0315
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.3213 0.3616
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0134 0.0152
Loa Loa (eye worm) hypothetical protein 0.0037 0.0677 0.0726
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0085 0.0131
Echinococcus multilocularis 0.0015 0.0085 0.0096
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0551 0.0625
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.004 0.0045
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0108 0.2605 0.2557
Loa Loa (eye worm) cytochrome P450 0.0015 0.0085 0.0051
Onchocerca volvulus 0.0258 0.6707 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0413 0.0426
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0064 0.0037
Brugia malayi Importin beta-1 subunit 0.0031 0.0521 0.079
Schistosoma mansoni single-minded 0.0053 0.111 0.1259
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0761 0.0821
Echinococcus granulosus single minded 2 0.0043 0.0835 0.0947
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0761 0.0863
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.1627 1
Schistosoma mansoni rab6-interacting 0.0021 0.025 0.0284
Echinococcus multilocularis lysosomal alpha glucosidase 0.0177 0.4508 0.5113
Brugia malayi Cytochrome P450 family protein 0.0015 0.0085 0.0035
Trichomonas vaginalis ran, putative 0.0023 0.0295 0.0383
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.111 0.1259
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0359 0.0479
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0134 0.0444
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.1627 0.1845
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0177 0.4508 0.5091
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.1627 0.1808
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0761 0.0863

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 21.8 nM Inhibition of C-terminal His6-tagged human Eg5 microtubule-stimulated ATPase activity ChEMBL. 21344920
Ki (binding) < 50 nM Inhibition of C-terminal His6-tagged human Eg5 basal ATPase activity ChEMBL. 21344920

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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