Detailed information for compound 1499329

Basic information

Technical information
  • TDR Targets ID: 1499329
  • Name: 5-acetylspiro[1,3-dihydroindene-2,6'-2,3,5,7- tetrahydro-s-indacene]-1'-one
  • MW: 316.393 | Formula: C22H20O2
  • H donors: 0 H acceptors: 2 LogP: 3.75 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)c1ccc2c(c1)CC1(C2)Cc2c(C1)cc1c(c2)C(=O)CC1
  • InChi: 1S/C22H20O2/c1-13(23)14-2-3-16-9-22(10-17(16)6-14)11-18-7-15-4-5-21(24)20(15)8-19(18)12-22/h2-3,6-8H,4-5,9-12H2,1H3
  • InChiKey: JQIMPXNUWOWHDI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5'-acetylspiro[2,3,5,7-tetrahydro-s-indacene-6,2'-indane]-1-one
  • 5'-acetyl-1-spiro[2,3,5,7-tetrahydro-s-indacene-6,2'-indane]one
  • 5-ethanoylspiro[1,3-dihydroindene-2,6'-2,3,5,7-tetrahydro-s-indacene]-1'-one
  • AIDS-145558
  • AIDS145558
  • NSC670408
  • Spiro[s-indacene-2(5H),2'-[2H]inden]-5-one, 5'-acetyl-1,1',3,3',6,7-hexahydro-
  • NCI60_024790

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum lysine--tRNA ligase 0.0027 0.0291 0.0201
Onchocerca volvulus 0.0017 0.0095 0.0086
Onchocerca volvulus 0.0017 0.0095 0.0086
Echinococcus multilocularis GPCR, family 2 0.0054 0.083 0.1105
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0151 0.2746 0.3654
Echinococcus multilocularis General substrate transporter 0.0103 0.1801 0.2396
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1172 1
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1172 1
Plasmodium vivax vivapain-2 0.0019 0.0132 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1172 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Schistosoma mansoni hypothetical protein 0.0205 0.3801 0.6295
Entamoeba histolytica hypothetical protein 0.008 0.1334 1
Entamoeba histolytica hypothetical protein 0.0027 0.0291 0.2127
Mycobacterium tuberculosis Conserved protein 0.004 0.0558 0.0973
Onchocerca volvulus 0.0017 0.0095 0.0086
Onchocerca volvulus 0.0019 0.0132 0.0123
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0497 0.3735
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0151 0.2746 1
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0558 0.4294
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0406 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0132 0.0203
Plasmodium falciparum calcium-dependent protein kinase 1 0.0037 0.0489 0.0404
Toxoplasma gondii lysine-tRNA ligase 0.0027 0.0291 0.0308
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0054 0.083 0.1105
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0558 0.091
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.2134 0.284
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0291 0.0462
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0363 0.2482
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0027 0.0291 0.0468
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.012 0.2134 0.284
Toxoplasma gondii protein kinase, putative 0.034 0.6465 1
Onchocerca volvulus 0.0019 0.0132 0.0123
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0132 0.0123
Schistosoma mansoni protein kinase 0.0037 0.0488 0.0795
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0037 0.0488 0.3648
Onchocerca volvulus 0.004 0.0558 0.0549
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1272 0.2096
Mycobacterium ulcerans sugar transporter 0.0017 0.0095 0.0136
Entamoeba histolytica protein kinase, putative 0.0037 0.0488 0.3614
Onchocerca volvulus 0.0017 0.0095 0.0086
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0132 0.0203
Entamoeba histolytica hypothetical protein 0.008 0.1334 1
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0558 0.4294
Schistosoma mansoni sugar transporter 0.0017 0.0095 0.0142
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0037 0.0489 0.0617
Trypanosoma brucei glucose transporter, putative 0.0037 0.0497 0.3735
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.008 0.1334 0.1775
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Plasmodium falciparum proline--tRNA ligase 0.0042 0.0591 0.051
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0095 0.0142
Leishmania major cathepsin L-like protease 0.0019 0.0132 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0095 0.0142
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0558 0.0973
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0031 0.0041
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0291 0.0462
Schistosoma mansoni jumonji domain containing protein 0.0085 0.1439 0.2373
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0896 0.1472
Toxoplasma gondii facilitative glucose transporter GT1 0.012 0.2134 0.3201
Onchocerca volvulus 0.0519 1 1
Plasmodium falciparum protein kinase 7 0.034 0.6465 0.6542
Schistosoma mansoni glucose transport protein 0.012 0.2134 0.3527
Brugia malayi hypothetical protein 0.0017 0.0095 0.0086
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.012 0.2134 0.284
Echinococcus multilocularis cysteine protease 0.0019 0.0132 0.0175
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0488 0.0795
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0488 0.065
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2608 0.2601
Loa Loa (eye worm) hypothetical protein 0.0036 0.0473 0.0464
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0138 0.0184
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0036 0.0473 0.063
Leishmania major cathepsin L-like protease 0.0071 0.1172 0.4063
Giardia lamblia PHD finger protein 15 0.0033 0.0406 0.8224
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0037 0.0489 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0497 0.3735
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0473 0.077
Onchocerca volvulus 0.004 0.0558 0.0549
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.008 0.1334 0.1775
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0036 0.0473 0.0464
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0558 0.091
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0027 0.0291 0.182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Loa Loa (eye worm) hypothetical protein 0.003 0.0363 0.0353
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0558 0.091
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Onchocerca volvulus 0.0252 0.4736 0.4731
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1272 0.1264
Trypanosoma brucei glucose transporter, putative 0.0037 0.0497 0.3735
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Loa Loa (eye worm) hypothetical protein 0.0057 0.0896 0.0888
Onchocerca volvulus 0.0017 0.0095 0.0086
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0389 0.0517
Echinococcus granulosus solute carrier family 22 0.0017 0.0095 0.0127
Leishmania major hypothetical protein, conserved 0.004 0.0558 0.1745
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0132 0.0038
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0497 0.3735
Leishmania major protein kinase, putative 0.0037 0.0488 0.1482
Leishmania major lysyl-tRNA synthetase, putative 0.0027 0.0291 0.0739
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0132 0.0138
Loa Loa (eye worm) hypothetical protein 0.0029 0.034 0.0331
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0132 0.0924
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0036 0.0473 0.3503
Plasmodium vivax hexose transporter 0.012 0.2134 0.2094
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Mycobacterium ulcerans beta-lactamase 0.004 0.0558 0.0905
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0406 0.0659
Echinococcus multilocularis peregrin 0.0033 0.0406 0.0541
Trichomonas vaginalis sugar transport protein, putative 0.0017 0.0095 0.0142
Onchocerca volvulus 0.0017 0.0095 0.0086
Mycobacterium leprae conserved hypothetical protein 0.004 0.0558 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0488 0.065
Loa Loa (eye worm) hypothetical protein 0.0117 0.2071 0.2063
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.012 0.2134 0.284
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0194 0.3595 0.5495
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0138 0.0044
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0473 0.077
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0558 0.0973
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0132 0.0175
Mycobacterium tuberculosis Conserved protein 0.004 0.0558 0.0973
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1272 0.2096
Brugia malayi Cam kinase protein 1 0.0037 0.0488 0.0479
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0095 0.0086
Schistosoma mansoni hypothetical protein 0.008 0.1334 0.2199
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0054 0.083 0.0822
Plasmodium falciparum calcium-dependent protein kinase 3 0.0037 0.0489 0.0404
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0488 0.0795
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.0211 0.0244
Trypanosoma brucei glucose transporter, putative 0.0037 0.0497 0.3735
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.2134 0.284
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2608 0.2601
Schistosoma mansoni hypothetical protein 0.0054 0.083 0.1363
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0138 0.0184
Brugia malayi Sugar transporter family protein 0.0017 0.0095 0.0086
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0291 0.0468
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0659 0.0877
Brugia malayi hypothetical protein 0.002 0.015 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0591 0.1872
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0017 0.0095 0.0136
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0389 0.0629
Plasmodium vivax proline--tRNA ligase, putative 0.0042 0.0591 0.051
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Brugia malayi MH2 domain containing protein 0.0144 0.2608 0.2601
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0497 0.081
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0095 0.0142
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0389 0.0517
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1172 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1272 0.2096
Trichomonas vaginalis conserved hypothetical protein 0.012 0.2134 0.3527
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0132 0.0175
Trichomonas vaginalis esterase, putative 0.004 0.0558 0.091
Brugia malayi Pre-SET motif family protein 0.0221 0.4132 0.4127
Echinococcus granulosus peregrin 0.0033 0.0406 0.0541
Leishmania major glucose transporter, lmgt2 0.0037 0.0497 0.1517
Brugia malayi hypothetical protein 0.0017 0.0095 0.0086
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0132 0.0175
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0017 0.0095 0.0142
Trypanosoma brucei glucose transporter, putative 0.0037 0.0497 0.3735
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0497 0.081
Schistosoma mansoni hypothetical protein 0.012 0.2134 0.3527
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0017 0.0095 0.0127
Onchocerca volvulus 0.0017 0.0095 0.0086
Plasmodium falciparum protein kinase 6 0.051 0.9831 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0132 0.0123
Loa Loa (eye worm) hypothetical protein 0.0027 0.0291 0.0282
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0406 0.0541
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0558 0.0549
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0132 0.0175
Loa Loa (eye worm) latrophilin receptor protein 2 0.0054 0.083 0.0822
Brugia malayi major facilitator superfamily protein 0.0017 0.0095 0.0086
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0542 0.0884
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Leishmania major glucose transporter, lmgt3 0.0037 0.0497 0.1517
Plasmodium vivax hypothetical protein, conserved 0.004 0.0558 0.0475
Echinococcus granulosus geminin 0.0205 0.3801 0.5059
Onchocerca volvulus Alhambra homolog 0.0033 0.0406 0.0397
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0171 0.3139 0.3133
Entamoeba histolytica hypothetical protein 0.008 0.1334 1
Onchocerca volvulus 0.004 0.0558 0.0549
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0542 0.0533
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0027 0.0291 0.2305
Plasmodium falciparum mitogen-activated protein kinase 2 0.0194 0.3595 0.3595
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0363 0.2482
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.2134 0.284
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0107 0.1873 0.2492
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Onchocerca volvulus 0.0032 0.0389 0.0379
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0138 0.0184
Schistosoma mansoni hypothetical protein 0.0054 0.083 0.1363
Trypanosoma brucei glucose transporter, putative 0.0037 0.0497 0.3735
Brugia malayi Cathepsin L-like precursor 0.0019 0.0132 0.0123
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0138 0.0129
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0017 0.0095 0.5
Brugia malayi isocitrate dehydrogenase 0.0019 0.0138 0.0129
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0363 0.0275
Echinococcus granulosus GPCR family 2 0.0054 0.083 0.1105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1172 1
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0659 0.0877
Leishmania major cathepsin L-like protease 0.0019 0.0132 0.0138
Schistosoma mansoni sugar transporter 0.0017 0.0095 0.0142
Echinococcus granulosus Sugar transporter ERD6 protein 0.0017 0.0095 0.0127
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0132 0.0203
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0497 0.081
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.087 0.7197
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1172 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0138 0.0044
Onchocerca volvulus 0.0017 0.0095 0.0086
Loa Loa (eye worm) RNA binding protein 0.0076 0.1272 0.1264
Plasmodium falciparum calcium-dependent protein kinase 5 0.0037 0.0489 0.0404
Plasmodium vivax SET domain protein, putative 0.0032 0.0389 0.0301
Brugia malayi Calcitonin receptor-like protein seb-1 0.0171 0.3139 0.3133
Leishmania major cathepsin L-like protease 0.0071 0.1172 0.4063
Trypanosoma brucei glucose transporter 1E 0.0037 0.0497 0.3735
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0171 0.3139 0.3133
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0558 0.0973
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0138 0.04
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0132 0.0123
Echinococcus multilocularis cysteine protease 0.0019 0.0132 0.0175
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0558 0.4294
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0488 0.065
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0138 0.0184
Echinococcus multilocularis solute carrier family 22 0.0017 0.0095 0.0127
Echinococcus multilocularis tumor protein p63 0.0393 0.7514 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0488 0.065
Echinococcus granulosus solute carrier family 22 0.0017 0.0095 0.0127
Brugia malayi beta-lactamase 0.004 0.0558 0.0549
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0363 0.0275
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0291 0.0468
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1272 0.2096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1172 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0138 0.04
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0138 0.04
Plasmodium falciparum calcium-dependent protein kinase 4 0.0037 0.0489 0.0404
Brugia malayi latrophilin 2 splice variant baaae 0.0117 0.2071 0.2063
Brugia malayi lysyl-tRNA synthetase 0.0027 0.0291 0.0282
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Schistosoma mansoni protein kinase 0.0037 0.0488 0.0795
Leishmania major glucose transporter, lmgt1 0.0037 0.0497 0.1517
Loa Loa (eye worm) hypothetical protein 0.0171 0.3139 0.3133
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0488 0.065
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Schistosoma mansoni hypothetical protein 0.0117 0.2071 0.3422
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0132 0.0203
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0132 0.0924
Brugia malayi glutaminase DH11.1 0.0318 0.6033 0.603
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0497 0.081
Loa Loa (eye worm) hypothetical protein 0.0033 0.0406 0.0397
Trichomonas vaginalis myo-inositol transporter, putative 0.0017 0.0095 0.0142
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0138 0.0068
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.105 0.8864
Echinococcus granulosus tar DNA binding protein 0.0076 0.1272 0.1693
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.1172 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Onchocerca volvulus 0.0057 0.0896 0.0888
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0132 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0095 0.0142
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1172 1
Echinococcus granulosus cathepsin l1 0.0019 0.0132 0.0175
Brugia malayi Cathepsin L-like precursor 0.0019 0.0132 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0542 0.0721
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Plasmodium falciparum calcium-dependent protein kinase 2 0.0037 0.0489 0.0404
Loa Loa (eye worm) hypothetical protein 0.0032 0.0389 0.0379
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Onchocerca volvulus 0.0019 0.0132 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Loa Loa (eye worm) hypothetical protein 0.0056 0.0867 0.0858
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0054 0.083 0.1105
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.4132 0.4127
Echinococcus multilocularis geminin 0.0205 0.3801 0.5059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0389 0.0629
Giardia lamblia Prolyl-tRNA synthetase 0.0036 0.0473 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1172 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0031 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0389 0.0629
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0132 0.0038
Brugia malayi beta-lactamase family protein 0.004 0.0558 0.0549
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0037 0.0489 0.0617
Schistosoma mansoni hypothetical protein 0.0054 0.083 0.1363
Brugia malayi Pre-SET motif family protein 0.0032 0.0389 0.0379
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0132 0.0038
Loa Loa (eye worm) hypothetical protein 0.004 0.0558 0.0549
Echinococcus granulosus cathepsin l1 0.0013 0.0009 0.0013
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0023 0.0211 0.0244
Schistosoma mansoni transcription factor LCR-F1 0.008 0.1334 0.2199
Loa Loa (eye worm) glutaminase 2 0.0318 0.6033 0.603
Toxoplasma gondii cathepsin CPL 0.0019 0.0132 0.0058
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0036 0.0473 0.0464
Leishmania major cathepsin L-like protease 0.0019 0.0132 0.0138
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0015 0.0054 0.0044
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0132 0.0123
Echinococcus granulosus General substrate transporter 0.0103 0.1801 0.2396
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Leishmania major cathepsin L-like protease 0.0071 0.1172 0.4063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0258 0.4848 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0558 0.0973
Plasmodium vivax vivapain-2 0.0019 0.0132 0.0038
Echinococcus granulosus sodium channel protein 0.0151 0.2746 0.3654
Brugia malayi Sugar transporter family protein 0.0017 0.0095 0.0086
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0406 0.0319
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0497 0.3735
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0095 0.0086
Loa Loa (eye worm) hypothetical protein 0.004 0.0558 0.0549
Echinococcus multilocularis calcium dependent protein kinase 0.0035 0.0443 0.059
Loa Loa (eye worm) cysteine protease 0.0019 0.0132 0.0123
Trichomonas vaginalis glutaminase, putative 0.0318 0.6033 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0138 0.0163
Trypanosoma brucei glucose transporter, putative 0.0037 0.0497 0.3735
Echinococcus multilocularis solute carrier family 22 0.0017 0.0095 0.0127
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0138 0.0184
Schistosoma mansoni glucose transporter 0.0017 0.0095 0.0142
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0497 0.081
Schistosoma mansoni hypothetical protein 0.0205 0.3801 0.6295
Mycobacterium ulcerans glutaminase 0.0318 0.6033 1
Plasmodium falciparum hexose transporter 0.012 0.2134 0.2094
Brugia malayi hypothetical protein 0.008 0.1334 0.1326
Giardia lamblia Lysyl-tRNA synthetase 0.0027 0.0291 0.5182
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0027 0.0291 0.182
Onchocerca volvulus 0.0017 0.0095 0.0086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0132 0.0203
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Schistosoma mansoni sugar transporter 0.0017 0.0095 0.0142
Brugia malayi Cathepsin L-like precursor 0.0019 0.0132 0.0123
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0095 0.0086
Brugia malayi Sugar transporter family protein 0.012 0.2134 0.2127
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0138 0.0214
Trypanosoma cruzi hexose transporter, putative 0.002 0.0164 0.0637
Schistosoma mansoni hypothetical protein 0.0014 0.0031 0.0036
Mycobacterium ulcerans integral membrane transport protein 0.0017 0.0095 0.0136
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0497 0.3735
Brugia malayi TAR-binding protein 0.0076 0.1272 0.1264
Onchocerca volvulus 0.0017 0.0095 0.0086
Loa Loa (eye worm) hypothetical protein 0.004 0.0558 0.0549
Leishmania major cathepsin L-like protease 0.0019 0.0132 0.0138
Mycobacterium tuberculosis Conserved protein 0.004 0.0558 0.0973
Plasmodium vivax calcium-dependent protein kinase, putative 0.0037 0.0489 0.0404
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0558 0.0973
Leishmania major hypothetical protein, conserved 0.003 0.0363 0.1009
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.1172 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0132 0.0123
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1172 1
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0132 0.0203
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0558 0.0973
Loa Loa (eye worm) hypothetical protein 0.0054 0.083 0.0822
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.1093 0.1084
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0542 0.0884
Echinococcus granulosus solute carrier family 22 0.0017 0.0095 0.0127
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0591 0.4607
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0054 0.083 0.1105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Echinococcus multilocularis solute carrier family 22 0.0017 0.0095 0.0127
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0226 0.0359
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0036 0.0473 0.077
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0591 0.4607
Loa Loa (eye worm) hypothetical protein 0.0036 0.0473 0.0464
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0132 0.0203
Brugia malayi major facilitator superfamily protein 0.0017 0.0095 0.0086
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0389 0.0517
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0363 0.0275
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0037 0.0488 0.065
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Toxoplasma gondii ABC1 family protein 0.004 0.0558 0.0726
Loa Loa (eye worm) sugar transporter 0.012 0.2134 0.2127
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0054 0.083 0.1105
Chlamydia trachomatis lysine--tRNA ligase 0.0027 0.0291 1
Schistosoma mansoni glucose transport protein 0.012 0.2134 0.3527
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0591 0.4607
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0558 0.091
Trypanosoma brucei glucose transporter 2A 0.0037 0.0497 0.3735
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0107 0.1873 0.2492
Trypanosoma brucei glucose transporter, putative 0.0037 0.0497 0.3735
Schistosoma mansoni hypothetical protein 0.0033 0.0406 0.0659
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0138 0.0068
Onchocerca volvulus 0.0017 0.0095 0.0086
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0037 0.0488 0.0479
Schistosoma mansoni hypothetical protein 0.0054 0.083 0.1363
Echinococcus granulosus calcium dependent protein kinase 0.0035 0.0443 0.059
Leishmania major glucose transporter/membrane transporter D2, putative 0.0037 0.0497 0.1517
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0095 0.0142
Plasmodium falciparum phd finger protein, putative 0.0033 0.0406 0.0319
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0389 0.0629
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0132 0.034
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0138 0.0184
Brugia malayi Latrophilin receptor protein 2 0.0054 0.083 0.0822
Schistosoma mansoni glucose transport protein 0.012 0.2134 0.3527
Brugia malayi jmjC domain containing protein 0.0107 0.1873 0.1865
Loa Loa (eye worm) hypothetical protein 0.004 0.0558 0.0549
Echinococcus multilocularis solute carrier family 22 0.0017 0.0095 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Mycobacterium ulcerans lipase LipD 0.004 0.0558 0.0905
Brugia malayi PHD-finger family protein 0.0033 0.0406 0.0397
Echinococcus multilocularis sodium channel protein 0.0151 0.2746 0.3654
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0132 0.0123
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0138 0.0129
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1272 0.1693
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0558 0.0905
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0558 0.0742
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0036 0.0473 0.7566
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.0013 0.5
Trypanosoma brucei glucose transporter, putative 0.0037 0.0497 0.3735
Loa Loa (eye worm) sugar transporter 0.0017 0.0095 0.0086
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.012 0.2134 0.284
Plasmodium vivax CDK-related protein kinase 6, putative 0.051 0.9831 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0123
Loa Loa (eye worm) fibroinase 0.0019 0.0132 0.0123
Brugia malayi RNA binding protein 0.0076 0.1272 0.1264
Onchocerca volvulus 0.0017 0.0095 0.0086
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0406 0.0488
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0406 0.0488
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0095 0.0086
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0558 0.0549
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0017 0.0095 0.0136
Onchocerca volvulus 0.0017 0.0095 0.0086
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Onchocerca volvulus 0.0019 0.0132 0.0123
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0132 0.0175
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1272 0.2096
Loa Loa (eye worm) hypothetical protein 0.0017 0.0095 0.0086
Onchocerca volvulus 0.0019 0.0132 0.0123
Onchocerca volvulus Putative transporter 0.0017 0.0095 0.0086
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1272 0.1264
Brugia malayi Cathepsin L-like precursor 0.0019 0.0132 0.0123
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0363 0.042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0132 0.0203
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0497 0.081
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0042 0.0591 0.0779
Echinococcus granulosus synaptic vesicle 2 protein 0.0017 0.0095 0.0127
Brugia malayi hypothetical protein 0.003 0.0363 0.0353
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0138 0.0091
Echinococcus granulosus solute carrier family 22 0.0017 0.0095 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0132 0.0203
Brugia malayi Cathepsin L-like precursor 0.0019 0.0132 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0497 0.081
Entamoeba histolytica cysteine protease, putative 0.0019 0.0132 0.0924
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0558 0.0905
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0363 0.2482
Echinococcus granulosus tumor protein p63 0.0393 0.7514 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1172 1
Schistosoma mansoni glutaminase 0.0318 0.6033 1
Echinococcus multilocularis lysine specific demethylase 5A 0.004 0.0542 0.0721
Loa Loa (eye worm) beta-lactamase 0.004 0.0558 0.0549
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.2134 0.284
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0558 0.091
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0558 0.0973
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0132 0.0175
Entamoeba histolytica protein kinase, putative 0.0037 0.0488 0.3614
Echinococcus multilocularis lysyl tRNA synthetase 0.0027 0.0291 0.0387
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0488 0.065
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0132 0.0203
Onchocerca volvulus 0.0017 0.0095 0.0086
Loa Loa (eye worm) hypothetical protein 0.004 0.0558 0.0549
Entamoeba histolytica hypothetical protein 0.008 0.1334 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0558 0.0549
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0037 0.0489 0.0404
Onchocerca volvulus 0.0017 0.0095 0.0086
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0037 0.0488 0.0479
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1172 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.1172 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0365 0.0486
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0558 0.0742
Brugia malayi beta-lactamase family protein 0.004 0.0558 0.0549
Mycobacterium leprae Probable lipase LipE 0.004 0.0558 1
Brugia malayi Bromodomain containing protein 0.0033 0.0406 0.0397
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0037 0.0488 0.0479
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0132 0.0203
Leishmania major cathepsin L-like protease 0.0019 0.0132 0.0138
Echinococcus multilocularis synaptic vesicle 2 protein 0.0017 0.0095 0.0127
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0132 0.0203
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0488 0.065
Loa Loa (eye worm) ctsf protein 0.0019 0.0132 0.0123
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0037 0.0489 0.0404
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0558 0.091
Echinococcus granulosus lysyl tRNA synthetase 0.0027 0.0291 0.0387
Schistosoma mansoni sugar transporter 0.0017 0.0095 0.0142
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Onchocerca volvulus 0.0017 0.0095 0.0086
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0558 0.091
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1272 0.1264
Onchocerca volvulus 0.0019 0.0132 0.0123
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0406 0.0541
Brugia malayi jmjC domain containing protein 0.004 0.0542 0.0533
Plasmodium vivax lysine--tRNA ligase, putative 0.0027 0.0291 0.0201
Trichomonas vaginalis set domain proteins, putative 0.0252 0.4736 0.7847
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0497 0.3735
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0095 0.0142
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0389 0.0461
Loa Loa (eye worm) glutaminase 0.0318 0.6033 0.603
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0138 0.04
Trypanosoma cruzi hexose transporter 0.0037 0.0497 0.3735
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0132 0.0203
Loa Loa (eye worm) hypothetical protein 0.0519 1 1
Trichomonas vaginalis glucose transporter, putative 0.0017 0.0095 0.0142
Mycobacterium ulcerans hypothetical protein 0.004 0.0558 0.0905
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0194 0.3595 0.3595
Loa Loa (eye worm) hypothetical protein 0.0037 0.0488 0.0479
Onchocerca volvulus 0.0019 0.0132 0.0123
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0095 0.0086
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0036 0.0473 0.063
Schistosoma mansoni protein kinase 0.0037 0.0488 0.0795
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0132 0.0123
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0037 0.0489 0.0617
Brugia malayi hypothetical protein 0.0017 0.0095 0.0086
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0591 0.1872

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -6.684 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.216 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.135 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -6.119 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.871 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.854 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.514 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.513 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.376 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.372 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.021 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0794 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 1.7783 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1095 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 14.581 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 501.1872 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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