Detailed information for compound 149939

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 325.325 | Formula: C15H15N7O2
  • H donors: 3 H acceptors: 6 LogP: 2.09 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1nc2c(n1)cc1c([nH]2)ccc(c1)OCCCCc1nnn[nH]1
  • InChi: 1S/C15H15N7O2/c23-15-17-12-8-9-7-10(4-5-11(9)16-14(12)18-15)24-6-2-1-3-13-19-21-22-20-13/h4-5,7-8H,1-3,6H2,(H2,16,17,18,23)(H,19,20,21,22)
  • InChiKey: CNYZQAJGKTXFPB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 3A, cGMP-inhibited Starlite/ChEMBL References
Homo sapiens purinergic receptor P2Y, G-protein coupled, 12 Starlite/ChEMBL References
Homo sapiens phosphodiesterase 3B, cGMP-inhibited References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132613 All targets in OG5_132613
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein Get druggable targets OG5_132613 All targets in OG5_132613
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132613 All targets in OG5_132613
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0699 0.4581 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0626 0.0626
Loa Loa (eye worm) hypothetical protein 0.0162 0.0917 0.0917
Brugia malayi TAR-binding protein 0.0066 0.0264 0.0264
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0231 0.0231
Plasmodium falciparum cysteine proteinase falcipain 1 0.038 0.2406 0.5252
Loa Loa (eye worm) hypothetical protein 0.0125 0.0664 0.0664
Echinococcus multilocularis calpain 0.0061 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0104 0.0522 0.0522
Brugia malayi Animal haem peroxidase family protein 0.0104 0.0522 0.0522
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1495 1 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0501 0.0501
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0231 0.0441
Echinococcus multilocularis microtubule associated protein 2 0.0768 0.5045 0.5045
Giardia lamblia Cathepsin L precursor 0.0163 0.0923 0.2475
Entamoeba histolytica cysteine protease, putative 0.0163 0.0923 0.1827
Loa Loa (eye worm) matrixin family protein 0.0047 0.0136 0.0136
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0163 0.0923 0.2475
Loa Loa (eye worm) hypothetical protein 0.0104 0.0522 0.0522
Echinococcus multilocularis geminin 0.0188 0.1099 0.1099
Trypanosoma brucei calpain-like protein, putative 0.0061 0.0231 0.0441
Plasmodium falciparum serine repeat antigen 7 0.0163 0.0923 0.2015
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.0923 0.2015
Loa Loa (eye worm) hypothetical protein 0.0218 0.1298 0.1298
Giardia lamblia Cathepsin L precursor 0.0163 0.0923 0.2475
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0218 0.1298 0.1298
Echinococcus granulosus pyruvate kinase 0.0037 0.0068 0.0068
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0163 0.0923 0.0923
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0068 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.4581 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0163 0.0923 0.0923
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0163 0.0923 0.0923
Brugia malayi Papain family cysteine protease containing protein 0.0163 0.0923 0.0923
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0264 0.0264
Giardia lamblia Cathepsin L precursor 0.0163 0.0923 0.2475
Entamoeba histolytica cysteine protease, putative 0.038 0.2406 0.514
Echinococcus granulosus cathepsin l cysteine peptidase 0.0699 0.4581 0.4581
Plasmodium falciparum serine repeat antigen 3 0.0163 0.0923 0.2015
Echinococcus multilocularis peroxidasin 0.0104 0.0522 0.0522
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0163 0.0923 0.0923
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0699 0.4581 0.4581
Plasmodium vivax vivapain-2 0.0699 0.4581 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0576 0.374 0.374
Echinococcus multilocularis hypothetical protein 0.0061 0.0231 0.0231
Trypanosoma brucei calpain-like protein, putative 0.0061 0.0231 0.0441
Trypanosoma cruzi cruzipain precursor, putative 0.0218 0.1298 0.1298
Loa Loa (eye worm) hypothetical protein 0.0163 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.0482 0.3098 0.3098
Leishmania major kinesin, putative 0.0043 0.0106 0.0202
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.4581 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0575 0.3731 0.8143
Brugia malayi hypothetical protein 0.0104 0.0522 0.0522
Loa Loa (eye worm) hypothetical protein 0.1 0.6629 0.6629
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.038 0.2406 0.2406
Loa Loa (eye worm) hypothetical protein 0.0037 0.0068 0.0068
Toxoplasma gondii preprocathepsin c precursor, putative 0.0163 0.0923 0.2015
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.1488 0.1488
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0444 0.0444
Trypanosoma brucei kinesin, putative 0.0043 0.0106 0.0202
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0061 0.0231 0.0441
Echinococcus granulosus calpain A 0.0061 0.0231 0.0231
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0068 0.0104
Loa Loa (eye worm) hypothetical protein 0.0218 0.1298 0.1298
Leishmania major pyruvate kinase 0.0037 0.0068 0.013
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0235 0.1414 0.1414
Giardia lamblia Cathepsin L precursor 0.0163 0.0923 0.2475
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0231 0.0231
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.1423 0.1423
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0068 0.0104
Echinococcus granulosus peroxidasin 0.0104 0.0522 0.0522
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0264 0.0264
Entamoeba histolytica cysteine protease, putative 0.038 0.2406 0.514
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0575 0.3731 0.3731
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0163 0.0923 0.0923
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0163 0.0923 0.2015
Entamoeba histolytica cysteine protease, putative 0.038 0.2406 0.514
Entamoeba histolytica cysteine proteinase, putative 0.038 0.2406 0.514
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0231 0.0231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.4581 1
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0176 0.1011 0.1011
Schistosoma mansoni peptidylglycine monooxygenase 0.0125 0.0664 0.0664
Loa Loa (eye worm) animal heme peroxidase 0.0104 0.0522 0.0522
Onchocerca volvulus Cathepsin L homolog 0.0699 0.4581 1
Echinococcus multilocularis calpain 5 0.0061 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0104 0.0522 0.0522
Brugia malayi Papain family cysteine protease containing protein 0.038 0.2406 0.2406
Brugia malayi Animal haem peroxidase family protein 0.0104 0.0522 0.0522
Entamoeba histolytica cysteine proteinase, putative 0.038 0.2406 0.514
Onchocerca volvulus 0.0101 0.0501 0.1055
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0444 0.0444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.0923 0.2015
Schistosoma mansoni calpain C (C02 family) 0.0061 0.0231 0.0231
Plasmodium vivax unspecified product 0.038 0.2406 0.5252
Brugia malayi Animal haem peroxidase family protein 0.0104 0.0522 0.0522
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0163 0.0923 0.2015
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0264 0.0264
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0163 0.0923 0.2015
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0077 0.0341 0.0341
Loa Loa (eye worm) hypothetical protein 0.0104 0.0522 0.0522
Loa Loa (eye worm) hypothetical protein 0.0104 0.0522 0.0522
Entamoeba histolytica cysteine protease, putative 0.0163 0.0923 0.1827
Trypanosoma cruzi cysteine peptidase, putative 0.0794 0.5223 0.5223
Loa Loa (eye worm) hypothetical protein 0.0699 0.4581 0.4581
Giardia lamblia Cathepsin B precursor 0.0575 0.3731 1
Brugia malayi Cathepsin L-like precursor 0.0699 0.4581 0.4581
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0794 0.5223 1
Onchocerca volvulus 0.0163 0.0923 0.198
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0163 0.0923 0.2015
Loa Loa (eye worm) hypothetical protein 0.0482 0.3098 0.3098
Trypanosoma brucei antigen, putative 0.0061 0.0231 0.0441
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0264 0.0264
Loa Loa (eye worm) fibroinase 0.0699 0.4581 0.4581
Loa Loa (eye worm) hypothetical protein 0.1027 0.6814 0.6814
Schistosoma mansoni peroxidasin 0.0104 0.0522 0.0522
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0163 0.0923 0.1827
Onchocerca volvulus 0.005 0.0156 0.0298
Onchocerca volvulus 0.0699 0.4581 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0444 0.0444
Leishmania major cathepsin L-like protease 0.0794 0.5223 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0163 0.0923 0.2015
Brugia malayi MH2 domain containing protein 0.0236 0.1423 0.1423
Toxoplasma gondii cathepsin B 0.0575 0.3731 0.8143
Echinococcus granulosus cathepsin l1 0.0699 0.4581 0.4581
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0699 0.4581 0.4581
Echinococcus multilocularis cathepsin L cysteine protease 0.0699 0.4581 0.4581
Plasmodium vivax serine-repeat antigen (SERA) 0.0163 0.0923 0.2015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0794 0.5223 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1495 1 1
Schistosoma mansoni calpain (C02 family) 0.0061 0.0231 0.0231
Plasmodium falciparum serine repeat antigen 4 0.0163 0.0923 0.2015
Trypanosoma brucei calpain-like protein, putative 0.0061 0.0231 0.0441
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1495 1 1
Entamoeba histolytica cysteine protease, putative 0.038 0.2406 0.514
Giardia lamblia Cathepsin B precursor 0.0163 0.0923 0.2475
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0061 0.0231 0.0231
Echinococcus granulosus calpain A 0.0176 0.1014 0.1014
Loa Loa (eye worm) calpain 0.0061 0.0231 0.0231
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0794 0.5223 1
Entamoeba histolytica cysteine protease, putative 0.038 0.2406 0.514
Schistosoma mansoni cathepsin s 0.0218 0.1298 0.1298
Schistosoma mansoni cathepsin C 0.0163 0.0923 0.0923
Entamoeba histolytica cysteine protease, putative 0.0163 0.0923 0.1827
Brugia malayi Cathepsin L-like precursor 0.0482 0.3098 0.3098
Echinococcus granulosus calpain 0.0061 0.0231 0.0231
Loa Loa (eye worm) blistered cuticle protein 3 0.0104 0.0522 0.0522
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.0923 0.2015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0794 0.5223 1
Plasmodium falciparum serine repeat antigen 1 0.0163 0.0923 0.2015
Brugia malayi Papain family cysteine protease containing protein 0.038 0.2406 0.2406
Echinococcus granulosus pyruvate kinase 0.0037 0.0068 0.0068
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0163 0.0923 0.2015
Loa Loa (eye worm) hypothetical protein 0.0104 0.0522 0.0522
Brugia malayi Cathepsin L-like precursor 0.0699 0.4581 0.4581
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.038 0.2406 0.2406
Entamoeba histolytica cysteine proteinase, putative 0.038 0.2406 0.514
Echinococcus granulosus calpain 5 0.0061 0.0231 0.0231
Brugia malayi Hemopexin family protein 0.003 0.002 0.002
Echinococcus multilocularis cysteine protease 0.0699 0.4581 0.4581
Loa Loa (eye worm) matrixin family protein 0.0051 0.0165 0.0165
Giardia lamblia Cysteine protease 0.0163 0.0923 0.2475
Brugia malayi cathepsin Z-like cysteine proteinase 0.0163 0.0923 0.0923
Plasmodium vivax calpain, putative 0.0061 0.0231 0.0503
Echinococcus multilocularis cathepsin L cysteine protease 0.0699 0.4581 0.4581
Mycobacterium leprae Probable pyruvate kinase PykA 0.0037 0.0068 0.5
Echinococcus multilocularis pyruvate kinase 0.0029 0.0014 0.0014
Plasmodium falciparum serine repeat antigen 5 0.0163 0.0923 0.2015
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0575 0.3731 0.3731
Entamoeba histolytica cysteine protease, putative 0.0163 0.0923 0.1827
Entamoeba histolytica cysteine proteinase, putative 0.038 0.2406 0.514
Leishmania major cathepsin L-like protease 0.0699 0.4581 0.8772
Plasmodium falciparum pyruvate kinase 0.0037 0.0068 0.0148
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0235 0.1414 0.1414
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.4581 1
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0235 0.1414 0.1414
Trypanosoma cruzi kinesin, putative 0.0043 0.0106 0.0106
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0068 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0699 0.4581 1
Onchocerca volvulus Cathepsin F homolog 0.0699 0.4581 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0163 0.0923 0.2015
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0163 0.0923 0.1827
Onchocerca volvulus 0.0104 0.0522 0.11
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0077 0.0341 0.0341
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0231 0.0231
Echinococcus granulosus cathepsin L 0.0163 0.0923 0.0923
Schistosoma mansoni pyruvate kinase 0.0037 0.0068 0.0068
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0231 0.0441
Chlamydia trachomatis pyruvate kinase 0.0037 0.0068 0.5
Onchocerca volvulus 0.0699 0.4581 1
Loa Loa (eye worm) animal heme peroxidase 0.0104 0.0522 0.0522
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.038 0.2406 0.5252
Onchocerca volvulus Matrix metalloproteinase homolog 0.0047 0.0136 0.0254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0482 0.3098 0.6763
Schistosoma mansoni hypothetical protein 0.0188 0.1099 0.1099
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0264 0.0264
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0163 0.0923 0.2475
Brugia malayi Peroxidasin 0.0104 0.0522 0.0522
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0264 0.0264
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0163 0.0923 0.2015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0444 0.0444
Giardia lamblia Cysteine protease 0.0163 0.0923 0.2475
Loa Loa (eye worm) hypothetical protein 0.0143 0.0792 0.0792
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0794 0.5223 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0794 0.5223 1
Schistosoma mansoni cathepsin F (C01 family) 0.0482 0.3098 0.3098
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0068 0.0068
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0068 0.0148
Onchocerca volvulus 0.0104 0.0522 0.11
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0068 0.0068
Echinococcus granulosus geminin 0.0188 0.1099 0.1099
Plasmodium falciparum serine repeat antigen 6 0.0163 0.0923 0.2015
Loa Loa (eye worm) hypothetical protein 0.0104 0.0522 0.0522
Schistosoma mansoni hypothetical protein 0.005 0.0156 0.0156
Echinococcus granulosus tar DNA binding protein 0.0066 0.0264 0.0264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.4581 1
Toxoplasma gondii cathepsin CPC2 0.0163 0.0923 0.2015
Trypanosoma cruzi cysteine proteinase, putative 0.038 0.2406 0.2406
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0163 0.0923 0.2015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.4581 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0068 0.013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0794 0.5223 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0231 0.0231
Leishmania major cathepsin L-like protease 0.0699 0.4581 0.8772
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.0923 0.2015
Entamoeba histolytica hypothetical protein 0.0163 0.0923 0.1827
Echinococcus multilocularis pyruvate kinase 0.0037 0.0068 0.0068
Brugia malayi cathepsin F-like cysteine proteinase 0.0218 0.1298 0.1298
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0218 0.1298 0.1298
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0068 0.013
Onchocerca volvulus Peroxidase homolog 0.0104 0.0522 0.11
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.038 0.2406 0.4607
Giardia lamblia Cathepsin L-like protease 0.0163 0.0923 0.2475
Loa Loa (eye worm) hypothetical protein 0.0104 0.0522 0.0522
Onchocerca volvulus Peroxidasin homolog 0.0104 0.0522 0.11
Brugia malayi Cathepsin L-like precursor 0.0218 0.1298 0.1298
Leishmania major cathepsin L-like protease 0.0794 0.5223 1
Entamoeba histolytica cysteine protease, putative 0.0699 0.4581 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0163 0.0923 0.2015
Giardia lamblia Cathepsin B precursor 0.0575 0.3731 1
Plasmodium vivax unspecified product 0.0163 0.0923 0.2015
Onchocerca volvulus 0.0104 0.0522 0.11
Brugia malayi calpain family protein 1 0.0162 0.0917 0.0917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.0923 0.2015
Loa Loa (eye worm) hypothetical protein 0.0235 0.1414 0.1414
Echinococcus granulosus cathepsin L 0.038 0.2406 0.2406
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.1488 0.1488
Echinococcus multilocularis cathepsin b 0.1495 1 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.0923 0.0923
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.4581 1
Giardia lamblia Cysteine protease 0.0163 0.0923 0.2475
Loa Loa (eye worm) animal heme peroxidase 0.0104 0.0522 0.0522
Brugia malayi calpain family protein 1 0.0162 0.0917 0.0917
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0163 0.0923 0.2015
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0163 0.0923 0.2015
Entamoeba histolytica cysteine protease, putative 0.038 0.2406 0.514
Entamoeba histolytica cysteine protease, putative 0.038 0.2406 0.514
Echinococcus granulosus cathepsin b 0.1495 1 1
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0264 0.0264
Leishmania major cathepsin L-like protease 0.0699 0.4581 0.8772
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0163 0.0923 0.0923
Echinococcus multilocularis cathepsin b 0.1495 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0163 0.0923 0.0923
Plasmodium vivax vivapain-1 0.038 0.2406 0.5252
Entamoeba histolytica cysteine protease, putative 0.038 0.2406 0.514
Toxoplasma gondii cathepsin CPL 0.0699 0.4581 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0482 0.3098 0.3098
Trypanosoma cruzi cruzipain precursor, putative 0.0794 0.5223 0.5223
Plasmodium falciparum serine repeat antigen 8 0.0163 0.0923 0.2015
Plasmodium vivax vivapain-3 0.038 0.2406 0.5252
Loa Loa (eye worm) hypothetical protein 0.0104 0.0522 0.0522
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.4581 1
Giardia lamblia Cathepsin B precursor 0.0575 0.3731 1
Toxoplasma gondii cathepsin CPC1 0.0163 0.0923 0.2015
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0162 0.0917 0.0917
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0163 0.0923 0.2015
Onchocerca volvulus Cathepsin L homolog 0.0699 0.4581 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0699 0.4581 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0444 0.0444
Brugia malayi Matrixin family protein 0.0051 0.0165 0.0165
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0061 0.0233 0.0233
Entamoeba histolytica cysteine protease, putative 0.0163 0.0923 0.1827
Echinococcus granulosus cathepsin b 0.1495 1 1
Brugia malayi Animal haem peroxidase family protein 0.0104 0.0522 0.0522
Brugia malayi cathepsin Z-like cysteine proteinase 0.0163 0.0923 0.0923
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0068 0.0148
Schistosoma mansoni cathepsin S (C01 family) 0.0163 0.0923 0.0923
Entamoeba histolytica cysteine proteinase, putative 0.0699 0.4581 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0699 0.4581 1
Loa Loa (eye worm) calpain family protein 1 0.0162 0.0917 0.0917
Schistosoma mansoni peroxidasin 0.0104 0.0522 0.0522
Schistosoma mansoni calpain-7 (C02 family) 0.0061 0.0231 0.0231
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0163 0.0923 0.2015
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0231 0.0231
Echinococcus granulosus cysteine protease 0.038 0.2406 0.2406
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0794 0.5223 1
Trypanosoma cruzi cysteine protease, putative 0.038 0.2406 0.2406
Onchocerca volvulus Matrilysin homolog 0.0047 0.0136 0.0254
Brugia malayi Blistered cuticle protein 3 0.0104 0.0522 0.0522
Entamoeba histolytica cysteine proteinase, putative 0.0699 0.4581 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.0923 0.2015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0699 0.4581 1
Loa Loa (eye worm) RNA binding protein 0.0066 0.0264 0.0264
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0699 0.4581 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0163 0.0923 0.0923
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0235 0.1414 0.1414
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0231 0.0441
Leishmania major cathepsin L-like protease 0.0794 0.5223 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0176 0.1011 0.1011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0699 0.4581 1
Schistosoma mansoni cathepsin B (C01 family) 0.0163 0.0923 0.0923
Giardia lamblia Cathepsin B precursor 0.0163 0.0923 0.2475
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.038 0.2406 0.2406
Onchocerca volvulus Peroxidase homolog 0.0104 0.0522 0.11
Giardia lamblia Hypothetical protein 0.0163 0.0923 0.2475
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0163 0.0923 0.2015
Echinococcus granulosus calpain 7 C02 family 0.0061 0.0231 0.0231
Plasmodium vivax vivapain-2 0.0699 0.4581 1
Brugia malayi Papain family cysteine protease containing protein 0.0163 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.0104 0.0522 0.0522
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0163 0.0923 0.0923
Brugia malayi Cathepsin L-like precursor 0.0482 0.3098 0.3098
Schistosoma mansoni survival motor neuron protein 0.005 0.0156 0.0156
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0699 0.4581 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0444 0.0444
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0163 0.0923 0.2015
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0163 0.0923 0.2015
Trypanosoma cruzi cysteine proteinase, putative 0.038 0.2406 0.2406
Loa Loa (eye worm) hypothetical protein 0.0104 0.0522 0.0522
Leishmania major cathepsin L-like protease 0.0699 0.4581 0.8772
Entamoeba histolytica cysteine protease, putative 0.0163 0.0923 0.1827
Loa Loa (eye worm) hypothetical protein 0.0163 0.0923 0.0923
Schistosoma mansoni cathepsin F (C01 family) 0.0699 0.4581 0.4581
Loa Loa (eye worm) hypothetical protein 0.0163 0.0923 0.0923
Loa Loa (eye worm) calpain 5 0.0043 0.0106 0.0106
Plasmodium vivax serine-repeat antigen (SERA) 0.0163 0.0923 0.2015
Trypanosoma cruzi cysteine peptidase, putative 0.0794 0.5223 0.5223
Trichomonas vaginalis conserved hypothetical protein 0.0163 0.0923 0.2015
Brugia malayi Cathepsin L-like precursor 0.0699 0.4581 0.4581
Leishmania major cathepsin L-like protease 0.0699 0.4581 0.8772
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.1027 0.6814 0.6814
Entamoeba histolytica cysteine protease, putative 0.038 0.2406 0.514
Brugia malayi Cathepsin L-like precursor 0.0699 0.4581 0.4581
Giardia lamblia Cathepsin L precursor 0.0163 0.0923 0.2475
Trypanosoma cruzi major cysteine proteinase, putative 0.0257 0.1565 0.1565
Onchocerca volvulus 0.0699 0.4581 1
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0068 0.0068
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0176 0.1011 0.1011
Schistosoma mansoni hypothetical protein 0.003 0.002 0.002
Loa Loa (eye worm) ctsf protein 0.0699 0.4581 0.4581
Brugia malayi Animal haem peroxidase family protein 0.0104 0.0522 0.0522
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0163 0.0923 0.2015
Trypanosoma cruzi cysteine peptidase, putative 0.038 0.2406 0.2406
Giardia lamblia Cathepsin B precursor 0.0163 0.0923 0.2475
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.4581 1
Brugia malayi Cathepsin L-like precursor 0.0699 0.4581 0.4581
Brugia malayi calpain 7 0.0061 0.0231 0.0231
Trypanosoma cruzi cysteine peptidase, putative 0.0699 0.4581 0.4581
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0063 0.0246 0.0246
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0163 0.0923 0.2015
Trypanosoma brucei calpain-like protein, putative 0.0061 0.0231 0.0441
Loa Loa (eye worm) hypothetical protein 0.1495 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0163 0.0923 0.0923
Brugia malayi Papain family cysteine protease containing protein 0.0699 0.4581 0.4581
Schistosoma mansoni microtubule-associated protein tau 0.0768 0.5045 0.5045
Giardia lamblia Hypothetical protein 0.0163 0.0923 0.2475
Schistosoma mansoni pyruvate kinase 0.0037 0.0068 0.0068
Onchocerca volvulus Dual oxidase homolog 0.0104 0.0522 0.11
Echinococcus granulosus cathepsin l1 0.0482 0.3098 0.3098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0699 0.4581 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0794 0.5223 1
Echinococcus multilocularis cathepsin L 0.038 0.2406 0.2406
Entamoeba histolytica cysteine protease, putative 0.038 0.2406 0.514
Giardia lamblia Cysteine protease 0.0163 0.0923 0.2475
Brugia malayi cathepsin F-like cysteine proteinase 0.0163 0.0923 0.0923
Trypanosoma brucei cysteine peptidase C (CPC) 0.0575 0.3731 0.7143
Echinococcus multilocularis pyruvate kinase 0.0037 0.0068 0.0068
Leishmania major pyruvate kinase 0.0037 0.0068 0.013
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0444 0.0444
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.038 0.2406 0.4607
Entamoeba histolytica cysteine protease, putative 0.038 0.2406 0.514
Trypanosoma cruzi major cysteine proteinase, putative 0.0163 0.0923 0.0923
Giardia lamblia Cathepsin L-like protease 0.0163 0.0923 0.2475
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0068 0.5
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0264 0.0264
Plasmodium falciparum serine repeat antigen 9 0.0163 0.0923 0.2015
Schistosoma mansoni Mername-AA248 (C02 family) 0.0061 0.0231 0.0231
Onchocerca volvulus 0.0482 0.3098 0.6749
Entamoeba histolytica cysteine protease, putative 0.038 0.2406 0.514
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0163 0.0923 0.2015
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0156 0.0156
Entamoeba histolytica cysteine proteinase 1, putative 0.038 0.2406 0.514
Loa Loa (eye worm) calpain family protein 1 0.0119 0.0626 0.0626
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1495 1 1
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0125 0.0664 0.0664
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0444 0.0444
Brugia malayi cathepsin L precursor 0.0163 0.0923 0.0923
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1495 1 1
Onchocerca volvulus 0.0699 0.4581 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0699 0.4581 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.0923 0.0923
Brugia malayi hypothetical protein 0.0245 0.1488 0.1488
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0068 0.0104
Echinococcus granulosus cathepsin L cysteine protease 0.038 0.2406 0.2406
Echinococcus multilocularis calpain 7 (C02 family) 0.0061 0.0231 0.0231
Giardia lamblia Encystation-specific protease 0.0163 0.0923 0.2475
Echinococcus multilocularis calpain family protein 1, d 0.0119 0.0626 0.0626
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0068 0.5
Echinococcus multilocularis calpain A 0.0176 0.1014 0.1014
Plasmodium falciparum serine repeat antigen 2 0.0163 0.0923 0.2015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0794 0.5223 1
Giardia lamblia Cathepsin B precursor 0.0163 0.0923 0.2475
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0444 0.0444
Echinococcus granulosus cathepsin L cysteine proteinase 0.0699 0.4581 0.4581
Schistosoma mansoni calpain-7 (C02 family) 0.0061 0.0231 0.0231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.4581 1
Trypanosoma cruzi cysteine peptidase, putative 0.0794 0.5223 0.5223
Loa Loa (eye worm) hypothetical protein 0.0218 0.1298 0.1298
Entamoeba histolytica cysteine protease, putative 0.038 0.2406 0.514
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.038 0.2406 0.2406
Entamoeba histolytica cysteine proteinase, putative 0.0482 0.3098 0.6687
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0231 0.0231
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0068 0.0148
Schistosoma mansoni hypothetical protein 0.0188 0.1099 0.1099
Onchocerca volvulus 0.0699 0.4581 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.4581 1
Plasmodium vivax unspecified product 0.0218 0.1298 0.2833
Giardia lamblia Cathepsin B precursor 0.0163 0.0923 0.2475
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0699 0.4581 0.4581
Schistosoma mansoni cathepsin F (C01 family) 0.0699 0.4581 0.4581
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.4581 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0699 0.4581 1
Leishmania major cysteine peptidase A (CPA) 0.0699 0.4581 0.8772
Plasmodium falciparum cysteine proteinase falcipain 3 0.0699 0.4581 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0699 0.4581 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0176 0.1011 0.1011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0163 0.0923 0.0923
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.4581 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0163 0.0923 0.2475
Loa Loa (eye worm) hypothetical protein 0.0104 0.0522 0.0522
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0231 0.0441
Brugia malayi fibroinase precursor 0.0163 0.0923 0.0923
Loa Loa (eye worm) cathepsin B 0.0575 0.3731 0.3731
Brugia malayi RNA binding protein 0.0066 0.0264 0.0264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0482 0.3098 0.6763
Giardia lamblia Pyruvate kinase 0.0037 0.0068 0.0181
Onchocerca volvulus Cathepsin L homolog 0.0163 0.0923 0.198
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0699 0.4581 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0522 0.0522
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0163 0.0923 0.2015
Onchocerca volvulus 0.0699 0.4581 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0163 0.0923 0.2015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0699 0.4581 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0163 0.0923 0.2015
Loa Loa (eye worm) animal heme peroxidase 0.0104 0.0522 0.0522
Loa Loa (eye worm) hypothetical protein 0.0245 0.1488 0.1488
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0794 0.5223 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0163 0.0923 0.0923
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0163 0.0923 0.2015
Brugia malayi calpain 5 0.0043 0.0106 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0163 0.0923 0.2015
Giardia lamblia Cathepsin L precursor 0.0163 0.0923 0.2475
Loa Loa (eye worm) hypothetical protein 0.0104 0.0522 0.0522
Brugia malayi cathepsin L-like precursor 0.0482 0.3098 0.3098
Loa Loa (eye worm) hypothetical protein 0.0482 0.3098 0.3098
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0163 0.0923 0.0923
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.1423 0.1423
Echinococcus multilocularis cathepsin L 0.0163 0.0923 0.0923
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0231 0.0231
Brugia malayi Cathepsin L-like precursor 0.0699 0.4581 0.4581
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0575 0.3731 0.7143
Onchocerca volvulus Peroxidasin homolog 0.0104 0.0522 0.11
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0163 0.0923 0.2475
Trypanosoma cruzi cysteine peptidase, putative 0.0218 0.1298 0.1298
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0264 0.0264
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0231 0.0231
Echinococcus multilocularis cysteine protease 0.0699 0.4581 0.4581
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0699 0.4581 1
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0068 0.0068
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0807 0.5317 0.5317
Echinococcus granulosus microtubule associated protein 2 0.0768 0.5045 0.5045
Loa Loa (eye worm) cysteine protease 0.0699 0.4581 0.4581
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0068 0.0148
Entamoeba histolytica cysteine proteinase 2 0.038 0.2406 0.514
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.038 0.2406 0.5252
Schistosoma mansoni dopamine-beta-monooxygenase 0.0125 0.0664 0.0664
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0068 0.0068
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0699 0.4581 0.4581
Onchocerca volvulus Chorion peroxidase homolog 0.0104 0.0522 0.11
Brugia malayi cathepsin L-like cysteine proteinase 0.0163 0.0923 0.0923
Trypanosoma cruzi kinesin, putative 0.0043 0.0106 0.0106
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0163 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.0163 0.0923 0.0923

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1.01 uM Inhibition of platelet aggregation using collagen as activating agent in rabbit platelet rich plasma (PRP) ChEMBL. 1321910
EC50 (functional) = 5.4 uM Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) ChEMBL. 1321910
EC50 (functional) = 5.4 uM Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) ChEMBL. 1321910
EC50 (functional) = 51 uM Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) ChEMBL. 1321910
EC50 (functional) = 51 uM Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) ChEMBL. 1321910
IC50 (binding) uM Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis; Not tested ChEMBL. 1321910
IC50 (binding) 0 uM Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis; Not tested ChEMBL. 1321910
IC50 (binding) = 0.01 uM Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis ChEMBL. 1321910
IC50 (binding) = 0.01 uM Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis ChEMBL. 1321910

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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