Detailed information for compound 1506016

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 360.8 | Formula: C19H13ClN6
  • H donors: 2 H acceptors: 3 LogP: 4.91 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)Nc1c(nc2n1cccn2)c1ccc2c(c1)cn[nH]2
  • InChi: 1S/C19H13ClN6/c20-14-3-5-15(6-4-14)23-18-17(24-19-21-8-1-9-26(18)19)12-2-7-16-13(10-12)11-22-25-16/h1-11,23H,(H,22,25)
  • InChiKey: SENUIYRNLCTXDG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Pim-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 4 Starlite/ChEMBL References
Homo sapiens Rho-associated, coiled-coil containing protein kinase 2 Starlite/ChEMBL References
Homo sapiens aurora kinase B Starlite/ChEMBL References
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum IPR002219,Protein kinase C, phorbol ester/diacylglycerol binding,domain-containing Get druggable targets OG5_131020 All targets in OG5_131020
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase PAK 4 Get druggable targets OG5_131977 All targets in OG5_131977
Echinococcus multilocularis serine:threonine protein kinase PAK 4 Get druggable targets OG5_131977 All targets in OG5_131977
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Echinococcus multilocularis rho associated protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Rho-associated protein kinase 1, putative Get druggable targets OG5_131020 All targets in OG5_131020
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Brugia malayi Serine/threonine-protein kinase Pim-3 Get druggable targets OG5_134863 All targets in OG5_134863
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus rho-associated protein kinase 1 Get druggable targets OG5_131020 All targets in OG5_131020
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi serine/threonine-protein kinase PAK 7 Get druggable targets OG5_131977 All targets in OG5_131977
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) STE/STE20/PAKB protein kinase Get druggable targets OG5_131977 All targets in OG5_131977
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_134863 All targets in OG5_134863
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_131020 All targets in OG5_131020
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Serine\/threonine protein kinase homolog Get druggable targets OG5_134863 All targets in OG5_134863
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative Get druggable targets OG5_134863 All targets in OG5_134863
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 aurora kinase B 303 aa 299 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0019 0.0227 0.0617
Onchocerca volvulus 0.0019 0.023 0.0525
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0033 0.0491 0.0491
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0985 0.2172
Loa Loa (eye worm) hypothetical protein 0.001 0.0072 0.0072
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0072 0.0072
Onchocerca volvulus 0.0175 0.3118 0.7107
Schistosoma mansoni ferritin 0.0009 0.0041 0.0111
Brugia malayi P21-Rho-binding domain containing protein 0.0019 0.0227 0.0227
Onchocerca volvulus 0.0033 0.0491 0.112
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0194 0.3467 0.3467
Entamoeba histolytica protein kinase, putative 0.0021 0.0272 0.0472
Plasmodium falciparum serine/threonine protein kinase, putative 0.007 0.1171 1
Loa Loa (eye worm) AUR protein kinase 0.007 0.1171 0.1171
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.3163 0.8599
Schistosoma mansoni thyroid hormone receptor 0.001 0.0072 0.0195
Schistosoma mansoni hypothetical protein 0.0019 0.0227 0.0617
Echinococcus granulosus FTZ F1 alpha 0.001 0.0072 0.0197
Loa Loa (eye worm) hypothetical protein 0.0011 0.0087 0.0087
Brugia malayi Protein kinase domain containing protein 0.0194 0.3467 0.3467
Brugia malayi WH1 domain containing protein 0.0019 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0019 0.023 0.023
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0072 0.0072
Trichomonas vaginalis STE family protein kinase 0.0021 0.0272 0.0531
Onchocerca volvulus 0.0033 0.0491 0.112
Schistosoma mansoni hypothetical protein 0.0019 0.0227 0.0617
Loa Loa (eye worm) hypothetical protein 0.0014 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0014 0.0141 0.0141
Schistosoma mansoni protein kinase 0.0021 0.0272 0.0739
Brugia malayi Fibronectin type III domain containing protein 0.0011 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.001 0.0072 0.0072
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0011 0.0087 0.0236
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.0041 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0072 0.0072
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0072 0.0164
Echinococcus granulosus ferritin 0.0009 0.0041 0.0112
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0072 0.0164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0072 0.0072
Entamoeba histolytica protein kinase, putative 0.0021 0.0272 0.0472
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0985 0.8026
Schistosoma mansoni protein kinase 0.0021 0.0272 0.0739
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0072 0.0197
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.007 0.1171 1
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0019 0.023 0.023
Mycobacterium ulcerans bacterioferritin BfrA 0.0009 0.0041 0.5
Trichomonas vaginalis AGC family protein kinase 0.007 0.1171 0.2601
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0072 0.0195
Loa Loa (eye worm) hypothetical protein 0.001 0.0072 0.0072
Schistosoma mansoni ferritin 0.0009 0.0041 0.0111
Brugia malayi serine/threonine-protein kinase PAK 7 0.0223 0.3991 0.3991
Loa Loa (eye worm) hypothetical protein 0.0018 0.0207 0.0207
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0021 0.0272 0.0746
Trypanosoma cruzi aurora B kinase, putative 0.007 0.1171 1
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0072 0.0197
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0009 0.0045 0.0045
Brugia malayi Pre-SET motif family protein 0.0031 0.0448 0.0448
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.006 0.0985 0.7425
Echinococcus multilocularis aurora kinase A 0.007 0.1171 0.3215
Giardia lamblia Aurora kinase 0.007 0.1171 1
Schistosoma mansoni vesicular amine transporter 0.0011 0.0087 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0072 0.0072
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0194 0.3467 0.9516
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0072 0.0197
Entamoeba histolytica protein kinase, putative 0.007 0.1171 1
Echinococcus multilocularis PAK box P21 Rho binding 0.0021 0.0272 0.0746
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0072 0.0195
Loa Loa (eye worm) hypothetical protein 0.0015 0.0154 0.0154
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0072 0.0197
Onchocerca volvulus 0.001 0.0072 0.0164
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0072 0.0164
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0019 0.023 0.023
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0072 0.0197
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0448 0.1217
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0154 0.0424
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0072 0.0197
Onchocerca volvulus 0.0167 0.2956 0.6738
Loa Loa (eye worm) hypothetical protein 0.0019 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.001 0.0072 0.0072
Entamoeba histolytica protein kinase, putative 0.007 0.1171 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0072 0.0197
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0021 0.0272 0.0746
Onchocerca volvulus 0.0033 0.0491 0.112
Schistosoma mansoni coup transcription factor 0.001 0.0072 0.0195
Loa Loa (eye worm) hypothetical protein 0.0014 0.0141 0.0141
Echinococcus granulosus twitchin 0.0017 0.0184 0.0506
Onchocerca volvulus 0.0014 0.0141 0.032
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.0041 0.5
Echinococcus granulosus serine:threonine protein kinase 12 B 0.007 0.1171 0.3215
Trichomonas vaginalis AGC family protein kinase 0.007 0.1171 0.2601
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0448 0.1228
Echinococcus multilocularis expressed protein 0.0009 0.0041 0.0112
Echinococcus granulosus defective proboscis extension response 0.0011 0.0087 0.0238
Echinococcus multilocularis protein kinase shaggy 0.006 0.0985 0.2703
Loa Loa (eye worm) hypothetical protein 0.0011 0.0087 0.0087
Echinococcus granulosus roundabout 2 0.0018 0.0207 0.0569
Onchocerca volvulus 0.0033 0.0491 0.112
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0246 0.0669
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0223 0.3991 0.3991
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0072 0.0197
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0019 0.023 0.023
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.384 0.384
Echinococcus multilocularis Immunoglobulin 0.0011 0.0087 0.0238
Schistosoma mansoni protein kinase 0.0021 0.0272 0.0739
Loa Loa (eye worm) AUR protein kinase 0.007 0.1171 0.1171
Onchocerca volvulus Tyrosine kinase homolog 0.0171 0.3028 0.6902
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0448 0.1217
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.007 0.1171 0.3215
Echinococcus granulosus expressed protein 0.0009 0.0041 0.0112
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0021 0.0272 0.0746
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0183 0.325 0.325
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0194 0.3467 0.7902
Schistosoma mansoni tyrosine kinase 0.002 0.0246 0.0669
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0072 0.0195
Schistosoma mansoni hypothetical protein 0.0019 0.0227 0.0617
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0072 0.0197
Schistosoma mansoni ferritin light chain 0.0009 0.0041 0.0111
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0072 0.0072
Brugia malayi ecdysteroid receptor 0.001 0.0072 0.0072
Onchocerca volvulus 0.0178 0.3163 0.7209
Brugia malayi serine/threonine-protein kinase 6 0.007 0.1171 0.1171
Leishmania major protein kinase, putative 0.007 0.1171 1
Echinococcus multilocularis ferritin 0.0009 0.0041 0.0112
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0204 0.3643 1
Schistosoma mansoni ferritin 0.0009 0.0041 0.0111
Loa Loa (eye worm) hypothetical protein 0.0014 0.0141 0.0141
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.006 0.0985 0.2703
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0072 0.0072
Onchocerca volvulus 0.0031 0.0448 0.102
Brugia malayi serine/threonine kinase 12 0.007 0.1171 0.1171
Onchocerca volvulus 0.0033 0.0491 0.112
Entamoeba histolytica protein kinase, putative 0.0021 0.0272 0.0472
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0072 0.0072
Entamoeba histolytica protein kinase, putative 0.0021 0.0272 0.0472
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0072 0.0197
Loa Loa (eye worm) hypothetical protein 0.0018 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0019 0.023 0.023
Plasmodium vivax glycogen synthase kinase 3, putative 0.006 0.0985 0.7425
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0194 0.3467 0.3467
Echinococcus multilocularis roundabout 2 0.0018 0.0207 0.0569
Schistosoma mansoni nuclear hormone receptor 0.001 0.0072 0.0195
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0011 0.0087 0.0238
Brugia malayi Protein kinase domain 0.0021 0.0272 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0072 0.0072
Loa Loa (eye worm) CMGC/GSK protein kinase 0.006 0.0985 0.0985
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0072 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0072 0.0072
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0019 0.023 0.023
Mycobacterium ulcerans bacterioferritin BfrB 0.0009 0.0041 0.5
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0021 0.0272 0.0746
Echinococcus granulosus protein kinase shaggy 0.006 0.0985 0.2703
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0072 0.0195
Trichomonas vaginalis AGC family protein kinase 0.007 0.1171 0.2601
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0072 0.0197
Loa Loa (eye worm) hypothetical protein 0.0011 0.0087 0.0087
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.3467 0.9426
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0448 0.1217
Brugia malayi LBP/BPI 0.0014 0.0141 0.0141
Echinococcus multilocularis rho associated protein kinase 0.0178 0.3163 0.8681
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0072 0.0195
Onchocerca volvulus 0.0033 0.0491 0.112
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0019 0.0227 0.0623
Entamoeba histolytica protein kinase domain containing protein 0.007 0.1171 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0448 0.1217
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0072 0.0195
Schistosoma mansoni serine/threonine protein kinase 0.007 0.1171 0.3185
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0021 0.0272 0.0746
Loa Loa (eye worm) hypothetical protein 0.0033 0.0491 0.0491
Brugia malayi Pre-SET motif family protein 0.0215 0.384 0.384
Giardia lamblia Kinase, CMGC GSK 0.006 0.0985 0.7928
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0227 0.0227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0072 0.0072
Brugia malayi nuclear hormone receptor 0.001 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0011 0.0087 0.0087
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0194 0.3467 0.3467
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0072 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0072 0.0072
Brugia malayi intracellular kinase 0.006 0.0985 0.0985
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0033 0.0491 0.0491
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0141 0.023
Brugia malayi serine/threonine protein kinase 6 0.007 0.1171 0.1171
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0019 0.023 0.023
Schistosoma mansoni hypothetical protein 0.0206 0.3678 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0427 0.1171
Schistosoma mansoni tyrosine kinase 0.0008 0.0019 0.0051
Schistosoma mansoni cell adhesion molecule 0.0015 0.0154 0.042
Echinococcus granulosus glycogen synthase kinase 3 beta 0.006 0.0985 0.2703
Schistosoma mansoni thyroid hormone receptor 0.001 0.0072 0.0195
Echinococcus multilocularis neuroglian 0.0014 0.014 0.0384
Loa Loa (eye worm) hypothetical protein 0.001 0.0072 0.0072
Echinococcus multilocularis Immunoglobulin 0.0011 0.0087 0.0238
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0204 0.3643 1
Brugia malayi hypothetical protein 0.0011 0.0087 0.0087
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0072 0.0072
Trichomonas vaginalis STE family protein kinase 0.0021 0.0272 0.0531
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0072 0.0072
Echinococcus granulosus rho-associated protein kinase 1 0.0178 0.3163 0.8681
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0072 0.0197
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0019 0.0227 0.0227
Loa Loa (eye worm) CMGC/GSK protein kinase 0.006 0.0985 0.0985
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0019 0.0227 0.0623
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.006 0.0985 0.2678
Onchocerca volvulus 0.0019 0.023 0.0525
Brugia malayi nuclear receptor NHR-88 0.001 0.0072 0.0072
Trypanosoma brucei RNA helicase, putative 0.0206 0.3678 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0087 0.0087
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0194 0.3467 0.9516
Echinococcus granulosus aurora kinase A 0.007 0.1171 0.3215
Schistosoma mansoni protein kinase 0.007 0.1171 0.3185
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0021 0.0272 0.0746
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0985 0.2172
Trypanosoma brucei aurora B kinase 0.007 0.1171 0.0692
Entamoeba histolytica p21-activated kinase 0.0021 0.0272 0.0472
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0072 0.0197
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.0041 0.5
Brugia malayi hypothetical protein 0.0019 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0019 0.023 0.023
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0011 0.0087 0.0236
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0072 0.0195
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0072 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0072 0.0072
Schistosoma mansoni ferritin light chain 0.0009 0.0041 0.0111
Schistosoma mansoni nephrin 0.0014 0.014 0.038
Echinococcus granulosus neuroglian 0.0014 0.014 0.0384
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0448 0.1228
Entamoeba histolytica protein kinase, putative 0.006 0.0985 0.8026
Trichomonas vaginalis STE family protein kinase 0.0021 0.0272 0.0531
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0072 0.0072
Schistosoma mansoni ferritin 0.0009 0.0041 0.0111
Onchocerca volvulus 0.006 0.0985 0.2245
Loa Loa (eye worm) hypothetical protein 0.0031 0.0448 0.0448
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0985 0.8026
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.007 0.1171 1
Toxoplasma gondii aurora kinase 0.007 0.1171 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0.0041 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0072 0.0072
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.007 0.1171 1
Plasmodium vivax serine/threonine protein kinase 6, putative 0.007 0.1171 1
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0072 0.0197
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0448 0.1228
Echinococcus granulosus Immunoglobulin 0.0011 0.0087 0.0238
Loa Loa (eye worm) AUR protein kinase 0.007 0.1171 0.1171
Schistosoma mansoni apoferritin-2 0.0009 0.0041 0.0111
Schistosoma mansoni apoferritin-2 0.0009 0.0041 0.0111
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0072 0.0195
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0072 0.0197
Giardia lamblia Kinase, CMGC GSK 0.006 0.0985 0.7928
Onchocerca volvulus 0.0033 0.0491 0.112
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0072 0.0072
Trichomonas vaginalis STE family protein kinase 0.0021 0.0272 0.0531
Loa Loa (eye worm) hypothetical protein 0.001 0.0072 0.0072
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0072 0.0195
Loa Loa (eye worm) hypothetical protein 0.0019 0.023 0.023
Trichomonas vaginalis STE family protein kinase 0.0021 0.0272 0.0531
Trichomonas vaginalis AGC family protein kinase 0.007 0.1171 0.2601
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0033 0.0491 0.0491
Brugia malayi steroid hormone receptor 0.001 0.0072 0.0072
Entamoeba histolytica protein kinase , putative 0.007 0.1171 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0072 0.0197
Brugia malayi hypothetical protein 0.0019 0.023 0.023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0072 0.0197
Schistosoma mansoni protein kinase 0.0019 0.0227 0.0617
Echinococcus multilocularis PAK box P21 Rho binding 0.0019 0.0227 0.0623
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.325 0.325
Loa Loa (eye worm) hypothetical protein 0.001 0.0072 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0227 0.0429
Brugia malayi P21-Rho-binding domain containing protein 0.0019 0.0227 0.0227
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0019 0.0227 0.0623
Echinococcus granulosus PAK box P21 Rho binding 0.0019 0.0227 0.0623
Brugia malayi hypothetical protein 0.0014 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.001 0.0072 0.0072
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0.0041 0.5
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0072 0.0072
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0087 0.0087
Onchocerca volvulus 0.0244 0.4387 1
Onchocerca volvulus 0.0033 0.0491 0.112
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0033 0.0491 0.0491
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0072 0.0072
Trichomonas vaginalis set domain proteins, putative 0.0244 0.4387 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) Inhibition of JAK2 ChEMBL. 21288717
Ki (binding) Inhibition of EGFR ChEMBL. 21288717
Ki (binding) = 0.121 uM Inhibition of GSK3-beta ChEMBL. 21288717
Ki (binding) = 1.565 uM Inhibition of Rock2 ChEMBL. 21288717
Ki (binding) = 2.805 uM Inhibition of aurora 2 ChEMBL. 21288717
Ki (binding) > 3.75 uM Inhibition of Pak4 ChEMBL. 21288717
Ki (binding) > 8.75 uM Inhibition of Pim1 ChEMBL. 21288717
Ki (binding) > 8.88 uM Inhibition of KDR ChEMBL. 21288717

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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