Detailed information for compound 1507418

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 492.61 | Formula: C35H28N2O
  • H donors: 0 H acceptors: 1 LogP: 7.71 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1[C@H](Cc2ccccc2)N=C(c2c(N1Cc1ccc(cc1)c1ccccc1)cccc2)c1ccccc1
  • InChi: 1S/C35H28N2O/c38-35-32(24-26-12-4-1-5-13-26)36-34(30-16-8-3-9-17-30)31-18-10-11-19-33(31)37(35)25-27-20-22-29(23-21-27)28-14-6-2-7-15-28/h1-23,32H,24-25H2/t32-/m0/s1
  • InChiKey: NIPKORLHEBKNOC-YTTGMZPUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.005 0.0205 0.0187
Brugia malayi hypoxia-induced factor 1 0.0153 0.0989 0.0974
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.021 0.1433 0.1418
Schistosoma mansoni AMP deaminase 0.0028 0.0038 0.002
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.005 0.0205 0.8155
Entamoeba histolytica adenosine deaminase, putative 0.0087 0.0489 0.0453
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.005 0.0205 0.0168
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0031 0.0058 0.004
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0066 0.0325 0.0288
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.021 0.1433 0.1418
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0058 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0033 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Loa Loa (eye worm) phosphatidylinositol 3 0.005 0.0205 0.0187
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0066 0.0325 0.0271
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0053 0.0035
Loa Loa (eye worm) AMP deaminase 0.0028 0.0038 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.004
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0031 0.0055 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Echinococcus granulosus protein arginine N methyltransferase 8 0.0031 0.0055 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Loa Loa (eye worm) phosphatidylinositol 3 0.021 0.1433 0.1418
Trypanosoma cruzi Thiopurine S-methyltransferase (TPMT), putative 0.0046 0.0171 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.005 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.002
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0031 0.0058 0.0002
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0099 0.0082
Trichomonas vaginalis adenosine deaminase, putative 0.0087 0.0489 0.0436
Leishmania major phosphatidylinositol 3-kinase, putative 0.005 0.0205 0.0168
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0048 0.0188 0.0151
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0053 0.0035
Entamoeba histolytica hypothetical protein 0.005 0.0205 0.0168
Echinococcus multilocularis adenosine deaminase 0.0087 0.0489 0.0472
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0058 0.004
Brugia malayi hypothetical protein 0.0048 0.0188 0.017
Loa Loa (eye worm) hypothetical protein 0.021 0.1433 0.1418
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0161 0.0143
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0031 0.0055 0.0038
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.005 0.0205 0.0168
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.005 0.0205 0.0187
Trypanosoma cruzi target of rapamycin kinase 3 0.0031 0.0058 0.002
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0031 0.0058 0.0058
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0058 0.004
Entamoeba histolytica adenosine deaminase, putative 0.0087 0.0489 0.0453
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0031 0.0058 0.002
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0031 0.0058 0.002
Echinococcus multilocularis Zinc finger, PHD finger 0.005 0.0205 0.0187
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0031 0.0058 0.004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0161 0.0143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0055 0.0238 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.005 0.0205 0.0168
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0055 0.0238 0.0221
Entamoeba histolytica hypothetical protein 0.0031 0.0058 0.002
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0031 0.0058 0.002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0161 0.0143
Giardia lamblia Phosphatidylinositol 4-kinase 0.0055 0.0238 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0031 0.0058 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0066 0.0325 0.0308
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0031 0.0058 0.004
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.071 0.0693
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0031 0.0058 0.002
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.005 0.0205 0.0168
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.005 0.0205 0.015
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0087 0.0489 0.0434
Trypanosoma brucei Thiopurine S-methyltransferase (TPMT), putative 0.0046 0.0171 0.0134
Leishmania major hypothetical protein, unknown function 0.0031 0.0058 0.002
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0031 0.0058 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Entamoeba histolytica hypothetical protein 0.0048 0.0188 0.0151
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0031 0.0055 0.0017
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0055 0.0238 0.0201
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0055 0.0238 0.0221
Leishmania major hypothetical protein, conserved 0.0031 0.0058 0.002
Schistosoma mansoni single-minded 0.0049 0.0198 0.018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0053 0.0035
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.005 0.0205 0.0187
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.005 0.0205 0.0168
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0031 0.0058 0.002
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.005 0.0205 0.0168
Schistosoma mansoni hypothetical protein 0.0031 0.0058 0.004
Brugia malayi adenosine monophosphate deaminase 0.0028 0.0038 0.002
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0055 0.0238 0.0221
Trichomonas vaginalis adenosine deaminase, putative 0.0087 0.0489 0.0436
Echinococcus granulosus AMP deaminase 2 0.0028 0.0038 0.002
Leishmania major phosphatidylinositol 4-kinase, putative 0.0055 0.0238 0.0201
Loa Loa (eye worm) phosphatidylinositol kinase 0.021 0.1433 0.1418
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0087 0.0489 0.0489
Brugia malayi Pre-SET motif family protein 0.003 0.0053 0.0035
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0031 0.0058 0.002
Onchocerca volvulus 0.021 0.1433 0.1831
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0031 0.0058 0.004
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0031 0.0058 0.002
Trichomonas vaginalis set domain proteins, putative 0.1034 0.7746 0.7734
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0031 0.0058 0.002
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0035
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0053 0.0035
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0058 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0048 0.0188 0.0151
Trypanosoma cruzi Thiopurine S-methyltransferase (TPMT), putative 0.0046 0.0171 0.0134
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0058 0.002
Loa Loa (eye worm) hypothetical protein 0.0059 0.0271 0.0254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.005 0.0205 0.015
Brugia malayi hypothetical protein 0.0165 0.1088 0.1072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0074 0.0385 0.0385
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0031 0.0058 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0058 0.004
Toxoplasma gondii target of rapamycin (TOR), putative 0.0031 0.0058 0.0058
Trypanosoma brucei Thiopurine S-methyltransferase (TPMT), putative 0.0046 0.0171 0.0134
Echinococcus granulosus adenosine deaminase 0.0087 0.0489 0.0472
Onchocerca volvulus 0.021 0.1433 0.1831
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0031 0.0058 0.004
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.021 0.1433 0.1418
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0031 0.0058 0.002
Trypanosoma cruzi hypothetical protein 0.0402 0.2903 0.2876
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0031 0.0058 0.002
Mycobacterium tuberculosis Conserved protein 0.0046 0.0171 0.0114
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0066 0.0325 0.0288
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.005 0.0205 0.0187
Echinococcus multilocularis serine protein kinase ATM 0.0031 0.0058 0.004
Entamoeba histolytica protein kinase rad3, putative 0.0031 0.0058 0.002
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.005 0.0205 0.015
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.005 0.0205 0.015
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0031 0.0058 0.004
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0066 0.0325 0.0308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.005 0.0205 0.015
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0031 0.0058 0.0002
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0031 0.0058 0.002
Onchocerca volvulus AMP deaminase 2 homolog 0.0028 0.0038 0.0026
Onchocerca volvulus 0.0028 0.0038 0.0026
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0031 0.0058 0.004
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0031 0.0058 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Brugia malayi PAS domain containing protein 0.0049 0.0198 0.018
Loa Loa (eye worm) hypothetical protein 0.0048 0.0188 0.017
Plasmodium vivax hypothetical protein 0.0031 0.0058 0.002
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.005 0.0205 0.0187
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0031 0.0058 0.002
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.005 0.0205 0.015
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.005 0.0205 0.015
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0031 0.0058 0.002
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0031 0.0058 0.002
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0031 0.0058 0.002
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0031 0.0055 0.0038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0161 0.0143
Onchocerca volvulus 0.0036 0.0099 0.0106
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0055 0.0238 0.0201
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0198 0.018
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.005 0.0205 0.0168
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0058 0.004
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0055 0.0238 0.0201
Loa Loa (eye worm) hypoxia-induced factor 1 0.0153 0.0989 0.0974
Plasmodium falciparum phosphatidylinositol 3-kinase 0.005 0.0205 0.0168
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0031 0.0058 0.0058
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0066 0.0325 0.0271
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0161 0.0143
Echinococcus multilocularis protein arginine methyltransferase 0.0031 0.0055 0.0038
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.005 0.0205 0.0187
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.005 0.0205 0.015
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0031 0.0058 0.002
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0031 0.0058 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0066 0.0325 0.0308
Leishmania major phosphatidylinositol 3-kinase, putative 0.0031 0.0058 0.002
Schistosoma mansoni adenosylhomocysteinase 0.0822 0.612 0.6113
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0031 0.0055 0.0017
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0031 0.0058 0.002
Loa Loa (eye worm) phosphatidylinositol 3 0.021 0.1433 0.1418
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0031 0.0055 0.0038
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0066 0.0325 0.0308
Echinococcus multilocularis 0.0055 0.0238 0.0221
Loa Loa (eye worm) hypothetical protein 0.005 0.0205 0.0187
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0031 0.0058 0.004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0161 0.0143
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0031 0.0058 0.004
Mycobacterium ulcerans adenosine deaminase 0.0087 0.0489 0.0393
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0053 0.0035
Onchocerca volvulus Adenosine deaminase homolog 0.0087 0.0489 0.061
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0031 0.0058 0.004
Echinococcus granulosus single minded 2 0.0036 0.0099 0.0082
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.005 0.0205 0.015
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.005 0.0205 0.0168
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.005 0.0205 0.0168
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0087 0.0489 0.0489
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.005 0.0205 0.0168
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0031 0.0058 0.004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0161 0.0143
Entamoeba histolytica hypothetical protein 0.0031 0.0058 0.002
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0047 0.0178 0.0178
Loa Loa (eye worm) phosphatidylinositol 3 0.0055 0.0238 0.0221
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0099 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Leishmania major hypothetical protein, conserved 0.0046 0.0171 0.0134
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.021 0.1433 0.1418
Plasmodium vivax SET domain protein, putative 0.003 0.0053 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0031 0.0058 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Schistosoma mansoni adenosine deaminase 0.0087 0.0489 0.0472
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0053 0.0053
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.005 0.0205 0.0168
Brugia malayi MH2 domain containing protein 0.0116 0.071 0.0693
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0031 0.0058 0.002
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0031 0.0058 0.002
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0031 0.0055 0.0038
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.005 0.0205 0.0187
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.021 0.1433 0.1418
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0058 0.0002
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0031 0.0058 0.002
Loa Loa (eye worm) hypothetical protein 0.0087 0.0489 0.0472
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Loa Loa (eye worm) hypothetical protein 0.0059 0.0271 0.0254
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.021 0.1433 0.1418
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0161 0.0143
Schistosoma mansoni adenosine deaminase-related 0.0087 0.0489 0.0472
Toxoplasma gondii FATC domain-containing protein 0.0031 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0059 0.0271 0.0254
Plasmodium falciparum adenosine deaminase 0.0087 0.0489 0.0453
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0066 0.0325 0.0288
Onchocerca volvulus 0.003 0.0053 0.0046
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0161 0.0143
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0031 0.0058 0.004
Schistosoma mansoni adenosylhomocysteinase 0.0822 0.612 0.6113
Leishmania major arginine N-methyltransferase-like protein 0.0031 0.0055 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0053 0.0035
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0066 0.0325 0.0308
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0066 0.0325 0.0288
Loa Loa (eye worm) hypothetical protein 0.0059 0.0271 0.0254
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0048 0.0188 0.0151
Leishmania major phosphatidylinositol kinase related protein, putative 0.0031 0.0058 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Entamoeba histolytica hypothetical protein 0.0031 0.0058 0.002
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0031 0.0058 0.002
Echinococcus granulosus serine protein kinase ATM 0.0031 0.0058 0.004
Leishmania major phosphatidylinositol kinase, putative 0.0031 0.0058 0.002
Echinococcus multilocularis AMP deaminase 2 0.0028 0.0038 0.002
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0048 0.0188 0.0151
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.005 0.0205 0.0187
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0053 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0055 0.0238 0.0201
Entamoeba histolytica hypothetical protein 0.0031 0.0058 0.002
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0058 0.004
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.005 0.0205 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.071 0.0693
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0031 0.0058 0.002
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.005 0.0205 0.0187
Leishmania major adenine aminohydrolase 0.0087 0.0489 0.0453
Schistosoma mansoni adenosylhomocysteinase 0.0822 0.612 0.6113
Treponema pallidum adenosine deaminase 0.0087 0.0489 0.5
Plasmodium vivax adenosine deaminase, putative 0.0087 0.0489 0.0453
Loa Loa (eye worm) hypothetical protein 0.0165 0.1088 0.1072
Brugia malayi Adenosine/AMP deaminase family protein 0.0087 0.0489 0.0472
Brugia malayi Pre-SET motif family protein 0.1006 0.7533 0.7528
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0087 0.0489 0.0434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0031 0.0058 0.0058
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0031 0.0058 0.002
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1006 0.7533 0.7528
Schistosoma mansoni fkbp-rapamycin associated protein 0.0031 0.0058 0.004
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0066 0.0325 0.0288
Onchocerca volvulus 0.1034 0.7746 1
Schistosoma mansoni adenosylhomocysteinase 0.0822 0.612 0.6113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.021 0.1433 0.1418
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0058 0.0002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.005 0.0205 0.0187
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0417 0.3015 0.2977
Echinococcus granulosus protein arginine methyltransferase 0.0031 0.0055 0.0038
Mycobacterium ulcerans methyltransferase 0.0046 0.0171 0.0072
Toxoplasma gondii AMP deaminase 0.0028 0.0038 0.0038

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.