Detailed information for compound 1514289

Basic information

Technical information
  • TDR Targets ID: 1514289
  • Name: 4-[(4-bromophenyl)-phenylmethylidene]-1-methy lpiperidine
  • MW: 342.273 | Formula: C19H20BrN
  • H donors: 0 H acceptors: 0 LogP: 5.1 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCC(=C(c2ccc(cc2)Br)c2ccccc2)CC1
  • InChi: 1S/C19H20BrN/c1-21-13-11-17(12-14-21)19(15-5-3-2-4-6-15)16-7-9-18(20)10-8-16/h2-10H,11-14H2,1H3
  • InChiKey: SMAVQOQAFDCUIZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(4-bromophenyl)-phenyl-methylene]-1-methyl-piperidine
  • 4-[(4-bromophenyl)-phenylmethylene]-1-methylpiperidine
  • 4-[(4-bromophenyl)-phenyl-methylidene]-1-methyl-piperidine
  • Oprea1_736434
  • AE-641/11702964

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0258 0.3817
Echinococcus multilocularis lamin dm0 0.0027 0.0157 0.014
Onchocerca volvulus 0.0036 0.0271 0.0217
Echinococcus granulosus Regulator of G protein signaling 20 0.0027 0.0164 0.0173
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0027 0.0164 0.0173
Loa Loa (eye worm) hypothetical protein 0.0025 0.0135 0.0251
Loa Loa (eye worm) hypothetical protein 0.0027 0.0164 0.0304
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0181 0.2097 0.5815
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0135 0.0568
Brugia malayi Regulator of G protein signaling domain containing protein 0.0027 0.0164 0.0304
Schistosoma mansoni regulator of G protein signaling 0.0027 0.0164 0.0173
Brugia malayi PXA domain containing protein 0.0027 0.0164 0.0304
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0258 0.1157
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0314 0.0351
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0647 1
Echinococcus multilocularis transcription factor btf3 0.0035 0.0258 0.0241
Brugia malayi hypothetical protein 0.0025 0.0135 0.0251
Schistosoma mansoni rab6-interacting 0.0039 0.0314 0.0351
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0283 0.0359
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0181 0.2097 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0271 0.0503
Loa Loa (eye worm) hypothetical protein 0.0049 0.044 0.0817
Echinococcus granulosus neuropeptide s receptor 0.0465 0.5655 0.6659
Echinococcus granulosus axis inhibition protein axin 0.0027 0.0164 0.0173
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0248 0.2938 0.345
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0467 0.2162
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0258 0.1157
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0647 0.0745
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0283 0.0314
Entamoeba histolytica hypothetical protein 0.0036 0.027 0.0321
Treponema pallidum fructose-bisphosphate aldolase 0.0292 0.3488 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0157 0.0292
Toxoplasma gondii ABC1 family protein 0.0036 0.0271 0.122
Schistosoma mansoni axis inhibition protein axin 0.0027 0.0164 0.0173
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0404
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0467 0.0531
Loa Loa (eye worm) hypothetical protein 0.0443 0.538 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.3488 1
Schistosoma mansoni regulator of G protein signaling 0.0027 0.0164 0.0173
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0298 0.0332
Loa Loa (eye worm) hypothetical protein 0.0027 0.0164 0.0304
Leishmania major macrophage migration inhibitory factor-like protein 0.0181 0.2097 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0314 0.0297
Schistosoma mansoni hypothetical protein 0.0169 0.1946 0.2279
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0283 0.0314
Echinococcus granulosus tumor protein p63 0.0338 0.4061 0.4777
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0467 0.0531
Loa Loa (eye worm) hypothetical protein 0.0039 0.0314 0.0583
Echinococcus granulosus death domain containing protein 0.0032 0.0216 0.0235
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0283 0.4218
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0271 0.0943
Brugia malayi isocitrate dehydrogenase 0.0016 0.0017 0.0032
Mycobacterium tuberculosis Conserved protein 0.0036 0.0271 0.0943
Brugia malayi beta-NAC-like protein 0.0035 0.0258 0.0479
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0271 0.4024
Echinococcus granulosus expressed protein 0.0027 0.0164 0.0173
Brugia malayi hypothetical protein 0.0027 0.0164 0.0304
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0271 0.4024
Loa Loa (eye worm) hypothetical protein 0.0036 0.0271 0.0503
Brugia malayi hypothetical protein 0.0036 0.027 0.0502
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0314 0.0351
Loa Loa (eye worm) hypothetical protein 0.0036 0.0271 0.0503
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0271 0.0503
Echinococcus multilocularis Regulator of G protein signaling 20 0.0027 0.0164 0.0147
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0181 0.2097 0.5815
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0135 0.1873
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0271 0.0322
Echinococcus multilocularis RUN 0.0039 0.0314 0.0297
Echinococcus multilocularis axis inhibition protein axin 0.0027 0.0164 0.0147
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0467 0.045
Schistosoma mansoni z-protein (S1r protein) 0.0027 0.0164 0.0173
Trypanosoma brucei protein kinase, putative 0.0052 0.0467 0.7133
Loa Loa (eye worm) beta-lactamase 0.0036 0.0271 0.0503
Schistosoma mansoni rab6-interacting 0.0039 0.0314 0.0351
Brugia malayi hypothetical protein 0.0016 0.0023 0.0043
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0467 0.0912
Loa Loa (eye worm) hypothetical protein 0.0027 0.0164 0.0304
Plasmodium falciparum macrophage migration inhibitory factor 0.0181 0.2097 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0271 0.03
Mycobacterium tuberculosis Conserved protein 0.0036 0.0271 0.0943
Onchocerca volvulus Huntingtin homolog 0.0122 0.1357 0.2297
Brugia malayi Bm-MIF-1, identical 0.0181 0.2097 0.3898
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.3488 1
Brugia malayi regulator of G-protein signaling egl-10 0.0027 0.0164 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.2097 0.5815
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0467 0.0573
Loa Loa (eye worm) hypothetical protein 0.0026 0.0151 0.0281
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0314 0.0297
Mycobacterium tuberculosis Conserved protein 0.0036 0.0271 0.0943
Schistosoma mansoni hypothetical protein 0.0039 0.0314 0.0351
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.3488 1
Echinococcus granulosus microtubule associated protein 2 0.069 0.8483 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0027 0.0164 0.0173
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0283 0.0266
Echinococcus granulosus neuropeptide receptor A26 0.0465 0.5655 0.6659
Brugia malayi Death domain containing protein 0.0032 0.0216 0.0401
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0283 0.4218
Loa Loa (eye worm) hypothetical protein 0.0027 0.0164 0.0304
Onchocerca volvulus 0.0036 0.0271 0.0217
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.3488 1
Schistosoma mansoni transcription factor btf3 0.0035 0.0258 0.0284
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0309 0.3702 0.3691
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0314 0.1427
Echinococcus multilocularis netrin receptor unc 5 0.0032 0.0216 0.0199
Loa Loa (eye worm) RGS-3 protein 0.0027 0.0164 0.0304
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0271 0.03
Echinococcus granulosus netrin receptor unc 5 0.0032 0.0216 0.0235
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.1611 1
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0467 0.0531
Echinococcus granulosus regulator of G protein signaling 7 0.0027 0.0164 0.0173
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0248 0.2938 0.546
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0647 0.0632
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0027 0.0164 0.0147
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0271 0.0322
Onchocerca volvulus 0.0036 0.0271 0.0217
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0271 0.0943
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0017 0.0032
Echinococcus granulosus RUN 0.0039 0.0314 0.0351
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0032 0.0216 0.0199
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0271 0.0943
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.3488 1
Echinococcus multilocularis geminin 0.0169 0.1946 0.1932
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0135 0.1873
Entamoeba histolytica hypothetical protein 0.0035 0.0258 0.0283
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0283 0.0314
Loa Loa (eye worm) hypothetical protein 0.0036 0.0271 0.0503
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0467 0.7133
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0248 0.2938 0.546
Echinococcus granulosus regulator of G protein signaling 3 0.0027 0.0164 0.0173
Brugia malayi intermediate filament protein 0.0027 0.0157 0.0292
Echinococcus multilocularis regulator of G protein signaling 7 0.0027 0.0164 0.0147
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0258 0.0283
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0135 0.0568
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.3488 1
Brugia malayi hypothetical protein 0.0039 0.0314 0.0583
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.1611 1
Echinococcus multilocularis neuropeptide receptor A26 0.0465 0.5655 0.5647
Echinococcus multilocularis regulator of G protein signaling 3 0.0027 0.0164 0.0147
Onchocerca volvulus 0.0039 0.0314 0.03
Loa Loa (eye worm) runx1 0.0056 0.0516 0.096
Entamoeba histolytica hypothetical protein 0.0036 0.027 0.0321
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0276 0.3283 0.6102
Brugia malayi Protein kinase domain containing protein 0.0033 0.023 0.0427
Brugia malayi MAP kinase sur-1 0.0052 0.0467 0.0867
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0467 0.7133
Echinococcus multilocularis expressed protein 0.0027 0.0164 0.0147
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0647 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0271 0.0503
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0173 0.1993 0.1979
Echinococcus granulosus beta-adrenergic receptor kinase 0.0029 0.0178 0.019
Schistosoma mansoni regulator of G protein signaling 0.0027 0.0164 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0283 0.0359
Leishmania major hypothetical protein, conserved 0.0025 0.0135 0.0568
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0077 0.0791 0.1469
Giardia lamblia Fructose-bisphosphate aldolase 0.0292 0.3488 1
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0258 0.0479
Schistosoma mansoni netrin receptor unc5 0.0032 0.0216 0.0235
Schistosoma mansoni hypothetical protein 0.0036 0.027 0.0299
Onchocerca volvulus Huntingtin homolog 0.0122 0.1357 0.2297
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0029 0.0178 0.033
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.027 0.0299
Onchocerca volvulus 0.0443 0.538 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0032 0.0217 0.0237
Loa Loa (eye worm) hypothetical protein 0.0036 0.0271 0.0503
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0271 0.0322
Echinococcus multilocularis lamin 0.0027 0.0157 0.014
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0135 0.0568
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0283 0.1279
Brugia malayi hypothetical protein 0.0443 0.538 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0467 0.0867
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0027 0.0164 0.0304
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0271 0.0322
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0135 0.0568
Brugia malayi hypothetical protein 0.0122 0.1357 0.2522
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0283 0.0314
Entamoeba histolytica hypothetical protein 0.0036 0.027 0.0321
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.027 0.0254
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0032 0.0216 0.0235
Echinococcus multilocularis neuropeptide s receptor 0.0465 0.5655 0.5647
Schistosoma mansoni hypothetical protein 0.0032 0.0216 0.0235
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0314 0.1427
Loa Loa (eye worm) hypothetical protein 0.0027 0.0157 0.0292
Echinococcus granulosus lamin dm0 0.0027 0.0157 0.0166
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0283 0.0266
Schistosoma mansoni lipoxygenase 0.0102 0.1101 0.1281
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.3488 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0467 0.7133
Echinococcus granulosus regulator of G protein signaling 3 0.0027 0.0164 0.0173
Loa Loa (eye worm) hypothetical protein 0.0122 0.1357 0.2522
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0178 0.019
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0467 0.2162
Brugia malayi beta-lactamase family protein 0.0036 0.0271 0.0503
Schistosoma mansoni lipoxygenase 0.0173 0.1993 0.2334
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0258 0.1157
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0314 0.0351
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0248 0.2938 0.2926
Brugia malayi Regulator of G protein signaling domain containing protein 0.0027 0.0164 0.0304
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.2707 1
Loa Loa (eye worm) hypothetical protein 0.0443 0.538 1
Brugia malayi PXA domain containing protein 0.0027 0.0164 0.0304
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.3488 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0271 0.0503
Loa Loa (eye worm) hypothetical protein 0.0122 0.1357 0.2522
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0283 0.0266
Echinococcus granulosus transcription factor btf3 0.0035 0.0258 0.0284
Loa Loa (eye worm) hypothetical protein 0.0039 0.0314 0.0583
Brugia malayi A-kinase anchor protein 10, precursor 0.0027 0.0164 0.0304
Trichomonas vaginalis esterase, putative 0.0036 0.0271 0.0322
Schistosoma mansoni lamin 0.0027 0.0157 0.0166
Schistosoma mansoni loxhd1 0.0039 0.0314 0.0351
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0283 0.0359
Brugia malayi hypothetical protein 0.0027 0.0164 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0258 0.0283
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0647 0.1203
Echinococcus granulosus intermediate filament protein 0.0027 0.0157 0.0166
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0647 0.1455
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0178 0.019
Schistosoma mansoni ankyrin 23/unc44 0.0032 0.0216 0.0235
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0271 0.0943
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0314 0.0297
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0157 0.0292
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0027 0.0164 0.0173
Brugia malayi beta-lactamase family protein 0.0036 0.0271 0.0503
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0467 0.0912
Echinococcus multilocularis tumor protein p63 0.0338 0.4061 0.4051
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.3488 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0467 0.7133
Leishmania major basic transcription factor 3a, putative 0.0035 0.0258 0.1157
Loa Loa (eye worm) hypothetical protein 0.0027 0.0164 0.0304
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0271 0.0943
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0173 0.1993 0.2334
Echinococcus granulosus axis inhibition protein axin 0.0027 0.0164 0.0173
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0017 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.0276 0.3283 0.3857
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0258 0.3817
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0467 0.045
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.1611 0.5927
Echinococcus granulosus Ankyrin 0.0032 0.0217 0.0237
Entamoeba histolytica hypothetical protein 0.0036 0.027 0.0321
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0283 0.0359
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0271 0.0943
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.3488 1
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0298 0.0282
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0283 0.4218
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0283 0.0314
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0157 0.0292
Loa Loa (eye worm) hypothetical protein 0.0027 0.0164 0.0304
Schistosoma mansoni regulator of G protein signaling 0.0027 0.0164 0.0173
Brugia malayi beta-lactamase 0.0036 0.0271 0.0503
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0271 0.122
Loa Loa (eye worm) hypothetical protein 0.0037 0.0283 0.0526
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0027 0.0164 0.0173
Brugia malayi Uncoordinated protein 44 0.0032 0.0216 0.0401
Schistosoma mansoni microtubule-associated protein tau 0.069 0.8483 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0467 0.2162
Echinococcus multilocularis Protein lozenge 0.0056 0.0516 0.05
Echinococcus multilocularis microtubule associated protein 2 0.069 0.8483 0.848
Schistosoma mansoni intermediate filament proteins 0.0027 0.0157 0.0166
Echinococcus multilocularis musashi 0.0027 0.0157 0.014
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0271 0.0254
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0271 0.0943
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0258 0.0283
Schistosoma mansoni regulator of G protein signaling 0.0027 0.0164 0.0173
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0314 0.0583
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0181 0.2097 0.3898
Onchocerca volvulus Netrin receptor homolog 0.0032 0.0216 0.0112
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.027 0.0299
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0283 0.0526
Schistosoma mansoni polycystin 1-related 0.0039 0.0314 0.0351
Loa Loa (eye worm) PXA domain-containing protein 0.0027 0.0164 0.0304
Echinococcus granulosus geminin 0.0169 0.1946 0.2279
Echinococcus granulosus nuclear factor of activated T cells 5 0.0309 0.3702 0.4353
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0248 0.2938 0.546
Onchocerca volvulus 0.0039 0.0314 0.03
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0647 0.0745
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0467 0.0912
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0271 0.0322
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0271 0.4024
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0216 0.0401
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0216 0.0401
Echinococcus granulosus lamin 0.0027 0.0157 0.0166
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0181 0.2097 1
Giardia lamblia Macrophage migration inhibitory factor 0.0181 0.2097 0.5659
Schistosoma mansoni lamin 0.0027 0.0157 0.0166
Leishmania major hypothetical protein, conserved 0.0036 0.0271 0.122
Schistosoma mansoni hypothetical protein 0.0169 0.1946 0.2279
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0258 0.0283
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0467 0.0912
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0258 0.3817
Brugia malayi regulator of G-protein signaling rgs-7 0.0027 0.0164 0.0304
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0077 0.0791 0.1469
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0647 0.3031
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.044 0.0499
Leishmania major macrophage migration inhibitory factor-like protein 0.0181 0.2097 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0647 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0467 0.7133
Onchocerca volvulus 0.0049 0.044 0.0541
Echinococcus multilocularis regulator of G protein signaling 0.0027 0.0164 0.0147
Echinococcus multilocularis beta adrenergic receptor kinase 0.0029 0.0178 0.0161
Schistosoma mansoni lozenge 0.0056 0.0516 0.059
Schistosoma mansoni axis inhibition protein axin 0.0027 0.0164 0.0173
Brugia malayi hypothetical protein 0.0039 0.0314 0.0583
Brugia malayi Doublecortin family protein 0.0039 0.0314 0.0583
Loa Loa (eye worm) hypothetical protein 0.0032 0.0216 0.0401
Echinococcus multilocularis Ankyrin 0.0032 0.0217 0.0201
Echinococcus multilocularis axis inhibition protein axin 0.0027 0.0164 0.0147
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0276 0.3283 0.6102
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0271 0.03
Echinococcus granulosus regulator of G protein signaling 7 0.0027 0.0164 0.0173
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0135 0.1873
Echinococcus multilocularis regulator of G protein signaling 7 0.0027 0.0164 0.0147
Echinococcus multilocularis regulator of G protein signaling 3 0.0027 0.0164 0.0147
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0647 0.1203

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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