Detailed information for compound 151476

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 475.544 | Formula: C28H25N7O
  • H donors: 1 H acceptors: 6 LogP: 5.02 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1nc2c(n1Cc1ccc3c(c1)c(=O)c1ccccc1cc3c1[nH]nnn1)nc(cc2C)C
  • InChi: 1S/C28H25N7O/c1-4-7-24-30-25-16(2)12-17(3)29-28(25)35(24)15-18-10-11-21-22(13-18)26(36)20-9-6-5-8-19(20)14-23(21)27-31-33-34-32-27/h5-6,8-14H,4,7,15H2,1-3H3,(H,31,32,33,34)
  • InChiKey: JHYQSQMDRKGUTN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens angiotensin II receptor, type 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyroglutamylated rfamide peptide receptor angiotensin II receptor, type 1 359 aa 403 aa 19.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0068 0.0027 0.0173
Brugia malayi G-protein coupled receptor 0.0269 0.0434 0.0693
Echinococcus multilocularis ring and YY1 binding protein 0.0068 0.0027 0.0045
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0166 0.0224 0.0367
Trichomonas vaginalis peptide N-glycanase, putative 0.0069 0.003 0.0668
Echinococcus multilocularis neuropeptide receptor 0.042 0.0737 0.1208
Echinococcus granulosus calcium activated potassium channel 0.0056 0.0003 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.0443 1
Echinococcus multilocularis g protein coupled receptor 0.0269 0.0434 0.0711
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0061 0.0014 0.0022
Onchocerca volvulus 0.0269 0.0434 0.2751
Leishmania major heat shock protein 83-1 0.014 0.0173 0.1498
Leishmania major hypothetical protein, conserved 0.0068 0.0027 0.0236
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0192 0.0277 0.0582
Brugia malayi steroid hormone receptor 0.0061 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Giardia lamblia Heat shock protein HSP 90-alpha 0.0127 0.0146 0.8132
Trypanosoma cruzi heat shock protein 90, putative 0.0114 0.0119 0.1753
Brugia malayi nuclear receptor NHR-88 0.0061 0.0014 0.0022
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0155 0.0203 0.0426
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0061 0.0014 0.0022
Loa Loa (eye worm) TYRA-2 protein 0.0269 0.0434 0.0693
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0061 0.0014 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0061 0.0014 0.0022
Brugia malayi Transforming growth factor beta like domain containing protein 0.0132 0.0157 0.025
Echinococcus granulosus neuropeptides capa receptor 0.0269 0.0434 0.0711
Brugia malayi putative neuropeptide receptor 0.0269 0.0434 0.0693
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0269 0.0434 0.0693
Trypanosoma brucei heat shock protein, putative 0.014 0.0173 0.2546
Schistosoma mansoni biogenic amine receptor 0.0269 0.0434 0.0434
Schistosoma mansoni biogenic amine (5HT) receptor 0.0269 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.0728 0.1361 0.2174
Brugia malayi Latrophilin receptor protein 2 0.0813 0.1532 0.2447
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0115 0.0122 0.1061
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Brugia malayi hypothetical protein 0.0269 0.0434 0.0693
Echinococcus granulosus sodium channel protein 0.0626 0.1154 0.189
Toxoplasma gondii PAN/Apple domain-containing protein 0.0155 0.0203 0.0426
Echinococcus granulosus neuropeptide receptor 0.0269 0.0434 0.0711
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Schistosoma mansoni myosin xvIII 0.0269 0.0434 0.0434
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0061 0.0014 0.0022
Brugia malayi putative neuropeptide receptor NPR1 0.0269 0.0434 0.0693
Echinococcus granulosus tm gpcr rhodopsin 0.0269 0.0434 0.0711
Leishmania major C-8 sterol isomerase-like protein 0.0391 0.0679 0.5883
Brugia malayi Calcitonin receptor-like protein seb-1 0.2495 0.493 0.7877
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0061 0.0014 0.0022
Echinococcus granulosus neuropeptides capa receptor 0.0269 0.0434 0.0711
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Loa Loa (eye worm) hypothetical protein 0.0061 0.0014 0.0022
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0061 0.0014 0.0022
Onchocerca volvulus 0.0155 0.0203 0.1285
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0092 0.0076 0.0124
Brugia malayi Steroid receptor seven-up type 2 0.0061 0.0014 0.0022
Toxoplasma gondii microneme protein MIC17C 0.0155 0.0203 0.0426
Brugia malayi Melatonin receptor type 1A 0.0269 0.0434 0.0693
Loa Loa (eye worm) hypothetical protein 0.0155 0.0203 0.0324
Schistosoma mansoni hypothetical protein 0.0068 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0061 0.0014 0.0022
Trypanosoma brucei heat shock protein, putative 0.014 0.0173 0.2546
Echinococcus multilocularis zinc finger protein Ran binding 0.0068 0.0027 0.0045
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0061 0.0014 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.0272 0.6145
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0112 0.0116 0.0186
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0061 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0253 0.5704
Brugia malayi PAN domain containing protein 0.0155 0.0203 0.0324
Brugia malayi ecdysteroid receptor 0.0061 0.0014 0.0022
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0068 0.0027 0.0045
Echinococcus multilocularis neuropeptide s receptor 0.077 0.1445 0.2367
Echinococcus multilocularis nmda type glutamate receptor 0.0113 0.0118 0.0193
Schistosoma mansoni neuropeptide F-like receptor 0.0269 0.0434 0.0434
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0328 0.0552 0.0904
Loa Loa (eye worm) calcium channel 0.0166 0.0224 0.0358
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0192 0.0277 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0269 0.0434 0.0693
Echinococcus granulosus adenylate cyclase 9 0.0064 0.0019 0.0031
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0269 0.0434 0.0434
Brugia malayi RE15519p 0.0269 0.0434 0.0693
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0061 0.0014 0.0022
Onchocerca volvulus 0.0155 0.0203 0.1285
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0127 0.0146 0.1266
Leishmania major heat shock protein 83-1 0.014 0.0173 0.1498
Echinococcus multilocularis adenylate cyclase 9 0.0064 0.0019 0.0031
Schistosoma mansoni neuropeptide receptor 0.0269 0.0434 0.0434
Loa Loa (eye worm) PAN domain-containing protein 0.0155 0.0203 0.0324
Loa Loa (eye worm) hypothetical protein 0.0166 0.0224 0.0358
Toxoplasma gondii microneme protein, putative 0.0155 0.0203 0.0426
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Loa Loa (eye worm) hypothetical protein 0.0068 0.0027 0.0044
Echinococcus granulosus alpha 1A adrenergic receptor 0.0269 0.0434 0.0711
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0328 0.0552 0.0882
Mycobacterium ulcerans heat shock protein 90 0.0127 0.0146 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0068 0.0027 0.0402
Loa Loa (eye worm) PAN domain-containing protein 0.0155 0.0203 0.0324
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0064 0.0019 0.0121
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0269 0.0434 0.0434
Echinococcus granulosus serotonin receptor 0.0269 0.0434 0.0711
Loa Loa (eye worm) hypothetical protein 0.3152 0.6259 1
Brugia malayi Dopamine receptor protein 1 0.0269 0.0434 0.0693
Chlamydia trachomatis SWIB complex protein 0.0192 0.0277 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0061 0.0014 0.0022
Brugia malayi PAN domain containing protein 0.0155 0.0203 0.0324
Echinococcus multilocularis rhodopsin orphan GPCR 0.0269 0.0434 0.0711
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0269 0.0434 0.0434
Trypanosoma cruzi Heat shock protein 83, putative 0.014 0.0173 0.2546
Brugia malayi G protein-coupled receptor 0.0269 0.0434 0.0693
Onchocerca volvulus 0.0269 0.0434 0.2751
Echinococcus multilocularis heat shock protein 90 0.014 0.0173 0.0283
Schistosoma mansoni hypothetical protein 0.0192 0.0277 0.0277
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0269 0.0434 0.0711
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0269 0.0434 0.0693
Onchocerca volvulus 0.0155 0.0203 0.1285
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Onchocerca volvulus 0.0269 0.0434 0.2751
Trypanosoma cruzi heat shock protein 85, putative 0.014 0.0173 0.2546
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0061 0.0014 0.0014
Brugia malayi PAN domain containing protein 0.0155 0.0203 0.0324
Trypanosoma cruzi heat shock protein 90, putative 0.014 0.0173 0.2546
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Echinococcus granulosus ecdysone induced protein 78C 0.0061 0.0014 0.0022
Brugia malayi Serotonin receptor 0.0269 0.0434 0.0693
Brugia malayi bZIP transcription factor family protein 0.0092 0.0076 0.0121
Echinococcus granulosus Zinc finger RanBP2 type 0.0068 0.0027 0.0045
Plasmodium vivax hypothetical protein, conserved 0.0192 0.0277 1
Leishmania major heat shock protein 83-1 0.014 0.0173 0.1498
Loa Loa (eye worm) hypothetical protein 0.0328 0.0552 0.0882
Schistosoma mansoni opsin-like receptor 0.0269 0.0434 0.0434
Trypanosoma cruzi WLM domain containing protein, putative 0.0068 0.0027 0.0402
Echinococcus granulosus g protein coupled receptor 0.0269 0.0434 0.0711
Schistosoma mansoni hypothetical protein 0.0269 0.0434 0.0434
Echinococcus granulosus 7tm_1 domain containing protein 0.0269 0.0434 0.0711
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0068 0.0027 0.0402
Onchocerca volvulus 0.0269 0.0434 0.2751
Schistosoma mansoni neuropeptide receptor 0.0269 0.0434 0.0434
Schistosoma mansoni brg-1 associated factor 0.0192 0.0277 0.0277
Echinococcus granulosus Transglutaminase 0.0069 0.003 0.0048
Toxoplasma gondii PAN domain-containing protein 0.2408 0.4756 1
Schistosoma mansoni TRABID protein (C64 family) 0.0068 0.0027 0.0027
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0127 0.0146 1
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0253 0.5704
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0269 0.0434 0.0434
Echinococcus granulosus somatostatin receptor 0.0269 0.0434 0.0711
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0269 0.0434 0.0434
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0269 0.0434 0.0434
Toxoplasma gondii microneme protein MIC17A 0.0155 0.0203 0.0426
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0166 0.0224 0.3299
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0269 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.0061 0.0014 0.0022
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.147 0.286 0.4686
Brugia malayi neuropeptide F receptor 0.0269 0.0434 0.0693
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0269 0.0434 0.0434
Leishmania major heat shock protein 83-1 0.014 0.0173 0.1498
Schistosoma mansoni hypothetical protein 0.0192 0.0277 0.0277
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0068 0.0027 0.0173
Onchocerca volvulus 0.0155 0.0203 0.1285
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0166 0.0224 0.0367
Echinococcus granulosus tm gpcr rhodopsin 0.0269 0.0434 0.0711
Echinococcus multilocularis endoplasmin 0.0127 0.0146 0.0239
Schistosoma mansoni glutamate receptor NMDA 0.0267 0.043 0.043
Schistosoma mansoni hypothetical protein 0.0069 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0267 0.043 0.0704
Loa Loa (eye worm) hypothetical protein 0.1801 0.3528 0.5637
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0115 0.0122 0.1804
Echinococcus granulosus rhodopsin orphan GPCR 0.0269 0.0434 0.0711
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0253 0.5704
Leishmania major heat shock protein 83-1 0.014 0.0173 0.1498
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0061 0.0014 0.0022
Echinococcus multilocularis heat shock protein 0.014 0.0173 0.0283
Echinococcus multilocularis fmrfamide receptor 0.0269 0.0434 0.0711
Loa Loa (eye worm) hypothetical protein 0.0068 0.0027 0.0044
Schistosoma mansoni jun-related protein 0.0075 0.0041 0.0041
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.147 0.286 0.4686
Loa Loa (eye worm) hypothetical protein 0.0061 0.0014 0.0022
Brugia malayi PAN domain containing protein 0.0155 0.0203 0.0324
Brugia malayi ORL1-like opioid receptor 0.0269 0.0434 0.0693
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0253 0.5704
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0068 0.0027 0.0402
Trypanosoma brucei C-8 sterol isomerase, putative 0.0391 0.0679 1
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0115 0.0122 0.1804
Echinococcus multilocularis neuropeptide Y receptor 0.0269 0.0434 0.0711
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0269 0.0434 0.0693
Loa Loa (eye worm) hypothetical protein 0.0064 0.0019 0.003
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0061 0.0014 0.0022
Echinococcus granulosus heat shock protein 90 0.014 0.0173 0.0283
Loa Loa (eye worm) hypothetical protein 0.0155 0.0203 0.0324
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Schistosoma mansoni coup transcription factor 0.0061 0.0014 0.0014
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0068 0.0027 0.0045
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0813 0.1532 0.2509
Echinococcus granulosus heat shock protein 90 0.0127 0.0146 0.0239
Onchocerca volvulus 0.0068 0.0027 0.0173
Schistosoma mansoni apoptosis regulator bax 0.0328 0.0552 0.0552
Giardia lamblia Grp94/Hsp90 0.0127 0.0146 0.8132
Schistosoma mansoni neuropeptide receptor 0.042 0.0737 0.0737
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Echinococcus granulosus neuropeptide Y receptor 0.0269 0.0434 0.0711
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0115 0.0122 0.1804
Echinococcus granulosus neuropeptide receptor 0.042 0.0737 0.1208
Schistosoma mansoni RNA binding protein 0.0068 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0061 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.009 0.0071 0.0113
Echinococcus granulosus g-protein coupled receptor 0.0269 0.0434 0.0711
Echinococcus multilocularis rhodopsin orphan GPCR 0.0269 0.0434 0.0711
Schistosoma mansoni thyroid hormone receptor 0.0061 0.0014 0.0014
Brugia malayi larval opioid receptor 0.0269 0.0434 0.0693
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0269 0.0434 0.0711
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Onchocerca volvulus 0.0072 0.0036 0.0226
Onchocerca volvulus 0.0269 0.0434 0.2751
Echinococcus granulosus rhodopsin orphan GPCR 0.0269 0.0434 0.0711
Echinococcus granulosus allatostatin A receptor 0.0835 0.1577 0.2583
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0115 0.0122 0.1804
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0061 0.0014 0.0022
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0178 0.0249 0.1576
Trypanosoma brucei heat shock protein, putative 0.014 0.0173 0.2546
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0068 0.0027 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0269 0.0434 0.0434
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0626 0.1154 0.189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0269 0.0434 0.0711
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0061 0.0014 0.0022
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0274 0.0443 0.0708
Echinococcus granulosus neuropeptide Y receptor 0.0269 0.0434 0.0711
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0081 0.0054 0.2064
Echinococcus granulosus g protein coupled receptor 0.0269 0.0434 0.0711
Schistosoma mansoni biogenic amine receptor 0.0269 0.0434 0.0434
Echinococcus granulosus tachykinin peptides receptor 99D 0.0269 0.0434 0.0711
Onchocerca volvulus Glucosylceramidase homolog 0.018 0.0253 0.1602
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0269 0.0434 0.0434
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0269 0.0434 0.0711
Echinococcus multilocularis neuropeptide FF receptor 2 0.0728 0.1361 0.2229
Entamoeba histolytica heat shock protein 90, putative 0.014 0.0173 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0116 0.0123 0.0196
Loa Loa (eye worm) latrophilin receptor protein 2 0.0813 0.1532 0.2447
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Trichomonas vaginalis heat shock protein, putative 0.0127 0.0146 0.3297
Loa Loa (eye worm) apoptosis regulator protein 0.0328 0.0552 0.0882
Echinococcus multilocularis neuropeptides capa receptor 0.0269 0.0434 0.0711
Loa Loa (eye worm) hypothetical protein 0.0061 0.0014 0.0022
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0391 0.0679 1
Trypanosoma cruzi heat shock protein 85, putative 0.014 0.0173 0.2546
Leishmania major hypothetical protein, conserved 0.0068 0.0027 0.0236
Onchocerca volvulus Neuropeptide F receptor homolog 0.0269 0.0434 0.2751
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0068 0.0027 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0253 0.5704
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.3152 0.6259 1
Echinococcus granulosus voltage dependent calcium channel 0.0166 0.0224 0.0367
Onchocerca volvulus 0.0155 0.0203 0.1285
Trypanosoma cruzi heat shock protein 85, putative 0.014 0.0173 0.2546
Schistosoma mansoni neuropeptide F-like receptor 0.0269 0.0434 0.0434
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0061 0.0014 0.0022
Toxoplasma gondii hypothetical protein 0.0155 0.0203 0.0426
Onchocerca volvulus 0.0068 0.0027 0.0173
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0068 0.0027 0.0045
Chlamydia trachomatis DNA topoisomerase I 0.0192 0.0277 1
Schistosoma mansoni adenoreceptor 0.0269 0.0434 0.0434
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0166 0.0224 0.0367
Toxoplasma gondii PAN domain-containing protein 0.0155 0.0203 0.0426
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0116 0.2621
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0269 0.0434 0.0711
Schistosoma mansoni ephrin receptor 0.0063 0.0017 0.0017
Onchocerca volvulus 0.0068 0.0027 0.0173
Onchocerca volvulus 0.0062 0.0015 0.0096
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0269 0.0434 0.0711
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0116 0.0116
Echinococcus granulosus peptide allatostatin:somatostatin 0.0269 0.0434 0.0711
Echinococcus granulosus FTZ F1 alpha 0.0061 0.0014 0.0022
Leishmania major heat shock protein 83-1 0.014 0.0173 0.1498
Echinococcus granulosus heat shock protein 0.014 0.0173 0.0283
Brugia malayi phosphoinositide-dependent protein kinase I 0.0112 0.0116 0.0186
Schistosoma mansoni hypothetical protein 0.0075 0.0041 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.0443 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0269 0.0434 0.0711
Leishmania major hypothetical protein, conserved 0.0068 0.0027 0.0236
Schistosoma mansoni amine GPCR 0.0269 0.0434 0.0434
Echinococcus multilocularis somatostatin receptor 0.0269 0.0434 0.0711
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Schistosoma mansoni biogenic amine (5HT) receptor 0.0269 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0192 0.0277 0.0453
Echinococcus granulosus SWI:SNF matrix associated 0.0192 0.0277 0.0453
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0061 0.0014 0.0022
Echinococcus granulosus glutamate NMDA receptor subunit 0.0267 0.043 0.0704
Schistosoma mansoni protein kinase 0.0133 0.0157 0.0157
Brugia malayi AKH receptor 0.0269 0.0434 0.0693
Trypanosoma brucei heat shock protein, putative 0.014 0.0173 0.2546
Schistosoma mansoni hypothetical protein 0.0269 0.0434 0.0434
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0835 0.1577 0.1577
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0027 0.0402
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0061 0.0014 0.0022
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0269 0.0434 0.0434
Echinococcus granulosus nmda type glutamate receptor 0.0113 0.0118 0.0193
Echinococcus multilocularis jun protein 0.0092 0.0076 0.0124
Brugia malayi Serotonin receptor 0.0269 0.0434 0.0693
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0328 0.0552 0.0904
Onchocerca volvulus 0.0269 0.0434 0.2751
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.0443 1
Schistosoma mansoni amine GPCR 0.0269 0.0434 0.0434
Trypanosoma brucei calpain, putative 0.0115 0.0122 0.1804
Loa Loa (eye worm) hypothetical protein 0.0061 0.0014 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0269 0.0434 0.0434
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0061 0.0014 0.0022
Leishmania major heat shock protein 83-1 0.014 0.0173 0.1498
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0027 0.0402
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1874 0.3675 0.602
Trypanosoma brucei heat shock protein, putative 0.014 0.0173 0.2546
Echinococcus multilocularis neuropeptide receptor 0.0269 0.0434 0.0711
Schistosoma mansoni hypothetical protein 0.0813 0.1532 0.1532
Schistosoma mansoni hypothetical protein 0.0813 0.1532 0.1532
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Brugia malayi hypothetical protein 0.0269 0.0434 0.0693
Echinococcus granulosus GPCR family 2 0.0813 0.1532 0.2509
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0112 0.0116 0.019
Echinococcus granulosus fmrfamide receptor 0.0269 0.0434 0.0711
Toxoplasma gondii microneme protein MIC4 0.0155 0.0203 0.0426
Giardia lamblia Heat shock protein HSP 90-alpha 0.014 0.0173 1
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Echinococcus granulosus rhodopsin orphan GPCR 0.0269 0.0434 0.0711
Trichomonas vaginalis heat shock protein, putative 0.0127 0.0146 0.3297
Echinococcus multilocularis GPCR, family 2 0.0813 0.1532 0.2509
Echinococcus granulosus biogenic amine 5HT receptor 0.0269 0.0434 0.0711
Leishmania major heat shock protein 83-1 0.014 0.0173 0.1498
Echinococcus granulosus zinc finger protein Ran binding 0.0068 0.0027 0.0045
Echinococcus multilocularis sex peptide receptor 0.0269 0.0434 0.0711
Brugia malayi hypothetical protein 0.0269 0.0434 0.0693
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0133 0.0157 0.0258
Echinococcus granulosus rhodopsin orphan GPCR 0.0269 0.0434 0.0711
Loa Loa (eye worm) hypothetical protein 0.02 0.0293 0.0468
Onchocerca volvulus 0.0269 0.0434 0.2751
Onchocerca volvulus 0.0269 0.0434 0.2751
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0061 0.0014 0.0022
Toxoplasma gondii hypothetical protein 0.0155 0.0203 0.0426
Onchocerca volvulus 0.0155 0.0203 0.1285
Schistosoma mansoni steroid hormone receptor ad4bp 0.0061 0.0014 0.0014
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0061 0.0014 0.0022
Schistosoma mansoni hypothetical protein 0.0328 0.0552 0.0552
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0116 0.0123 0.0196
Trypanosoma brucei hypothetical protein, conserved 0.0068 0.0027 0.0402
Echinococcus granulosus orexin receptor type 2 0.0269 0.0434 0.0711
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0061 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Echinococcus multilocularis dro:myosuppressin receptor 0.0269 0.0434 0.0711
Brugia malayi hypothetical protein 0.0269 0.0434 0.0693
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0061 0.0014 0.0014
Brugia malayi G-protein coupled receptor 0.0269 0.0434 0.0693
Toxoplasma gondii heat shock protein 90, putative 0.014 0.0173 0.0363
Echinococcus multilocularis G-protein coupled receptor, putative 0.0269 0.0434 0.0711
Treponema pallidum heat shock protein 90 0.0127 0.0146 1
Loa Loa (eye worm) steroid hormone receptor 0.0061 0.0014 0.0022
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0328 0.0552 0.0552
Toxoplasma gondii PAN domain-containing protein 0.0155 0.0203 0.0426
Echinococcus multilocularis SWI:SNF matrix associated 0.0192 0.0277 0.0453
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0115 0.0122 0.1061
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0116 0.2621
Schistosoma mansoni hypothetical protein 0.0328 0.0552 0.0552
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0269 0.0434 0.0711
Brugia malayi PAN domain containing protein 0.0155 0.0203 0.0324
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.0443 1
Trypanosoma brucei hypothetical protein, conserved 0.0068 0.0027 0.0402
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.3076 0.6104 1
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0166 0.0224 0.3299
Leishmania major hypothetical protein, conserved 0.0068 0.0027 0.0236
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Echinococcus multilocularis G protein coupled receptor 139 0.042 0.0737 0.1208
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0269 0.0434 0.0434
Onchocerca volvulus 0.0269 0.0434 0.2751
Toxoplasma gondii subtilisin SUB12 0.0155 0.0203 0.0426
Trichomonas vaginalis heat shock protein, putative 0.014 0.0173 0.39
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Schistosoma mansoni nuclear hormone receptor 0.0061 0.0014 0.0014
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0269 0.0434 0.0711
Brugia malayi PAN domain containing protein 0.0155 0.0203 0.0324
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0269 0.0434 0.0693
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0061 0.0014 0.0014
Schistosoma mansoni opsin-like receptor 0.0269 0.0434 0.0434
Brugia malayi latrophilin 2 splice variant baaae 0.1682 0.3288 0.5253
Echinococcus multilocularis rhodopsin orphan GPCR 0.0269 0.0434 0.0711
Echinococcus multilocularis serotonin receptor 0.0269 0.0434 0.0711
Brugia malayi G protein-coupled receptor F59B2.13 0.0269 0.0434 0.0693
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0192 0.0277 0.0442
Echinococcus granulosus neuropeptide receptor A26 0.077 0.1445 0.2367
Brugia malayi follicle stimulating hormone receptor 0.0269 0.0434 0.0693
Loa Loa (eye worm) melatonin receptor type 1A 0.0269 0.0434 0.0693
Echinococcus granulosus adenylate cyclase type IX 0.009 0.0072 0.0117
Toxoplasma gondii hypothetical protein 0.0111 0.0113 0.0239
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0115 0.0122 0.1804
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0269 0.0434 0.0434
Onchocerca volvulus 0.0269 0.0434 0.2751
Schistosoma mansoni amine GPCR 0.0269 0.0434 0.0434
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0269 0.0434 0.0434
Echinococcus multilocularis neuropeptide receptor A26 0.077 0.1445 0.2367
Brugia malayi PAN domain containing protein 0.0155 0.0203 0.0324
Schistosoma mansoni voltage-gated cation channel 0.0166 0.0224 0.0224
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0192 0.0277 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0115 0.0122 0.1804
Loa Loa (eye worm) PAN domain-containing protein 0.0155 0.0203 0.0324
Echinococcus granulosus hypothetical protein 0.0269 0.0434 0.0711
Schistosoma mansoni protein kinase 0.0133 0.0157 0.0157
Echinococcus granulosus g protein coupled receptor 0.0269 0.0434 0.0711
Schistosoma mansoni zinc finger protein 0.0068 0.0027 0.0027
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0166 0.0224 0.0358
Brugia malayi hypothetical protein 0.0269 0.0434 0.0693
Loa Loa (eye worm) hypothetical protein 0.1682 0.3288 0.5253
Echinococcus granulosus endoplasmin 0.0127 0.0146 0.0239
Echinococcus granulosus rhodopsin orphan GPCR 0.0269 0.0434 0.0711
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0115 0.0122 0.1804
Brugia malayi SWIB/MDM2 domain containing protein 0.0192 0.0277 0.0442
Echinococcus multilocularis ecdysone induced protein 78C 0.0061 0.0014 0.0022
Echinococcus granulosus rhodopsin orphan GPCR 0.0269 0.0434 0.0711
Schistosoma mansoni alpha-1 adrenergic receptor 0.0269 0.0434 0.0434
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0061 0.0014 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.0443 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0269 0.0434 0.0434
Brugia malayi Tachykinin-like peptides receptor 99D 0.0728 0.1361 0.2174
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0813 0.1532 0.2447
Brugia malayi Dopamine receptor protein 2 0.0269 0.0434 0.0693
Onchocerca volvulus 0.0835 0.1577 1
Loa Loa (eye worm) voltage-dependent calcium channel 0.0166 0.0224 0.0358
Echinococcus granulosus rhodopsin orphan GPCR 0.0269 0.0434 0.0711
Echinococcus multilocularis fmrfamide receptor 0.0269 0.0434 0.0711
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0269 0.0434 0.2751
Brugia malayi heat shock protein 90 0.014 0.0173 0.0276
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0068 0.0027 0.0044
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0269 0.0434 0.0434
Trypanosoma brucei RNA helicase, putative 0.0312 0.0519 0.7646
Trypanosoma cruzi heat shock protein 85, putative 0.0127 0.0146 0.2152
Echinococcus multilocularis serotonin receptor 0.0269 0.0434 0.0711
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0269 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.0155 0.0203 0.0324
Schistosoma mansoni hypothetical protein 0.0192 0.0277 0.0277
Brugia malayi nuclear hormone receptor 0.0061 0.0014 0.0022
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0269 0.0434 0.0693
Trichomonas vaginalis glucosylceramidase, putative 0.0274 0.0443 1
Onchocerca volvulus 0.0269 0.0434 0.2751
Brugia malayi hypothetical protein 0.0269 0.0434 0.0693
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0166 0.0224 0.0367
Loa Loa (eye worm) hypothetical protein 0.0523 0.0947 0.1513
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0269 0.0434 0.0711
Trypanosoma brucei heat shock protein, putative 0.014 0.0173 0.2546
Echinococcus multilocularis calcium activated potassium channel 0.0056 0.0003 0.0005
Schistosoma mansoni hypothetical protein 0.0269 0.0434 0.0434
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0061 0.0014 0.0022
Leishmania major heat shock protein 83-1 0.014 0.0173 0.1498
Schistosoma mansoni neuropeptide receptor 0.0269 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Brugia malayi hypothetical protein 0.1801 0.3528 0.5637
Schistosoma mansoni hypothetical protein 0.0328 0.0552 0.0552
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0027 0.0402
Toxoplasma gondii microneme protein MIC17B 0.0155 0.0203 0.0426
Echinococcus multilocularis SWI:SNF matrix associated 0.0192 0.0277 0.0453
Loa Loa (eye worm) hypothetical protein 0.0061 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0155 0.0203 0.0324
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0132 0.0157 0.0257
Toxoplasma gondii ran binding protein 0.0068 0.0027 0.0057
Schistosoma mansoni opsin-like receptor 0.0269 0.0434 0.0434
Loa Loa (eye worm) PAN domain-containing protein 0.0155 0.0203 0.0324
Loa Loa (eye worm) hypothetical protein 0.0175 0.0243 0.0388
Echinococcus multilocularis ephrin type A receptor 4 A 0.0063 0.0017 0.0027
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0269 0.0434 0.0711
Echinococcus granulosus ephrin type A receptor 4 A 0.0063 0.0017 0.0027
Onchocerca volvulus 0.0269 0.0434 0.2751
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0132 0.0157 0.0257
Onchocerca volvulus 0.0064 0.0019 0.0121
Loa Loa (eye worm) brahma associated protein 0.0192 0.0277 0.0442
Echinococcus multilocularis g protein coupled receptor 0.0269 0.0434 0.0711
Loa Loa (eye worm) TK/EPH protein kinase 0.008 0.0051 0.0081
Trypanosoma brucei heat shock protein, putative 0.014 0.0173 0.2546
Brugia malayi hypothetical protein 0.0269 0.0434 0.0693
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0127 0.0146 0.5
Loa Loa (eye worm) hypothetical protein 0.0155 0.0203 0.0324
Loa Loa (eye worm) hypothetical protein 0.0061 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Toxoplasma gondii PAN domain-containing protein 0.2408 0.4756 1
Schistosoma mansoni endoplasmin 0.014 0.0173 0.0173
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0166 0.0224 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0192 0.0277 0.6247
Loa Loa (eye worm) hypothetical protein 0.0155 0.0203 0.0324
Loa Loa (eye worm) hypothetical protein 0.0111 0.0113 0.0181
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0166 0.0224 0.0224
Echinococcus multilocularis rhodopsin orphan GPCR 0.0269 0.0434 0.0711
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0253 0.5704
Onchocerca volvulus 0.0155 0.0203 0.1285
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0115 0.0122 0.1804
Leishmania major heat shock protein 83-1 0.014 0.0173 0.1498
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0269 0.0434 0.0711
Trypanosoma brucei heat shock protein 90, putative 0.014 0.0173 0.2546
Plasmodium falciparum heat shock protein 90 0.014 0.0173 0.5833
Echinococcus multilocularis orexin receptor type 2 0.0269 0.0434 0.0711
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0127 0.0146 0.0239
Brugia malayi sulfakinin receptor protein 0.1801 0.3528 0.5637
Schistosoma mansoni heat shock protein 0.014 0.0173 0.0173
Schistosoma mansoni hypothetical protein 0.0813 0.1532 0.1532
Brugia malayi PAN domain containing protein 0.0155 0.0203 0.0324
Onchocerca volvulus 0.0061 0.0014 0.0086
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0115 0.0122 0.1804
Onchocerca volvulus Protein ultraspiracle homolog 0.0061 0.0014 0.0086
Echinococcus granulosus 7TM GPCR rhodopsin 0.0269 0.0434 0.0711
Schistosoma mansoni RAR-like nuclear receptor 0.0061 0.0014 0.0014
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0269 0.0434 0.0693
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0269 0.0434 0.0711
Onchocerca volvulus 0.0069 0.003 0.0188
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0626 0.1154 1
Loa Loa (eye worm) hypothetical protein 0.0813 0.1532 0.2447
Loa Loa (eye worm) hypothetical protein 0.0111 0.0113 0.0181
Brugia malayi photoreceptor-specific nuclear receptor 0.0061 0.0014 0.0022
Brugia malayi Thioredoxin family protein 0.0069 0.003 0.0047
Brugia malayi brahma associated protein 60 kDa 0.0192 0.0277 0.0442
Echinococcus multilocularis FTZ F1 alpha 0.0061 0.0014 0.0022
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0269 0.0434 0.0711
Brugia malayi Caveolin-1 0.0523 0.0947 0.1513
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0061 0.0014 0.0022
Schistosoma mansoni heat shock protein 0.014 0.0173 0.0173
Toxoplasma gondii heat shock protein HSP90 0.014 0.0173 0.0363
Trypanosoma brucei calpain-like protein, putative 0.0115 0.0122 0.1804
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0274 0.0443 0.0708
Loa Loa (eye worm) hypothetical protein 0.0062 0.0015 0.0024
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0269 0.0434 0.0693
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0253 0.5704
Echinococcus multilocularis g-protein coupled receptor 0.0269 0.0434 0.0711
Echinococcus multilocularis SWI:SNF matrix associated 0.0192 0.0277 0.0453
Echinococcus multilocularis heat shock protein 90 0.0127 0.0146 0.0239
Loa Loa (eye worm) hypothetical protein 0.0155 0.0203 0.0324
Onchocerca volvulus 0.0269 0.0434 0.2751
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0166 0.0224 0.0367
Schistosoma mansoni thyroid hormone receptor 0.0061 0.0014 0.0014
Schistosoma mansoni biogenic amine receptor 0.0269 0.0434 0.0434
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0061 0.0014 0.0022
Schistosoma mansoni serine-type protease inhibitor 0.5004 1 1
Onchocerca volvulus 0.0269 0.0434 0.2751
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0269 0.0434 0.0711
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0115 0.0122 0.1804
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0269 0.0434 0.0693
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0061 0.0014 0.0022
Leishmania major heat shock protein 83-1 0.014 0.0173 0.1498
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0061 0.0014 0.0022
Echinococcus granulosus neuropeptide s receptor 0.077 0.1445 0.2367
Onchocerca volvulus 0.0061 0.0014 0.0086
Schistosoma mansoni hypothetical protein 0.1682 0.3288 0.3288
Brugia malayi Protein kinase domain containing protein 0.0112 0.0116 0.0186
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0166 0.0224 0.0367
Loa Loa (eye worm) adenylyl cyclase 3 0.0151 0.0196 0.0312
Trypanosoma cruzi heat shock protein 90, putative 0.0127 0.0146 0.2152
Echinococcus granulosus ring and YY1 binding protein 0.0068 0.0027 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0061 0.0014 0.0022
Echinococcus granulosus biogenic amine 5HT receptor 0.0269 0.0434 0.0711
Echinococcus multilocularis neuropeptide Y receptor 0.0269 0.0434 0.0711
Brugia malayi hypothetical protein 0.0269 0.0434 0.0693
Trypanosoma cruzi WLM domain containing protein, putative 0.0068 0.0027 0.0402
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0112 0.0116 0.019
Loa Loa (eye worm) neuropeptide F receptor 0.0269 0.0434 0.0693
Brugia malayi PAN domain containing protein 0.0155 0.0203 0.0324
Schistosoma mansoni histamine h1 receptor 0.0269 0.0434 0.0434
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Loa Loa (eye worm) hypothetical protein 0.0835 0.1577 0.2519
Leishmania major hypothetical protein, conserved 0.0068 0.0027 0.0236
Echinococcus multilocularis Transglutaminase 0.0069 0.003 0.0048
Echinococcus multilocularis adenylate cyclase type IX 0.009 0.0072 0.0117
Schistosoma mansoni hypothetical protein 0.0269 0.0434 0.0434
Echinococcus multilocularis neuropeptides capa receptor 0.0269 0.0434 0.0711
Brugia malayi Dopamine receptor 0.0269 0.0434 0.0693
Trypanosoma brucei heat shock protein 90, putative 0.014 0.0173 0.2546
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0115 0.0122 0.1804
Echinococcus multilocularis g protein coupled receptor 0.0269 0.0434 0.0711
Onchocerca volvulus 0.0192 0.0277 0.1755
Echinococcus multilocularis voltage dependent calcium channel 0.0166 0.0224 0.0367
Schistosoma mansoni endoplasmin 0.014 0.0173 0.0173
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0133 0.0157 0.0258
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0061 0.0014 0.0022
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0061 0.0014 0.0022
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0068 0.0027 0.0402
Loa Loa (eye worm) PAN domain-containing protein 0.0155 0.0203 0.0324
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0115 0.0122 0.1061
Echinococcus multilocularis allatostatin A receptor 0.0835 0.1577 0.2583
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0269 0.0434 0.0711
Loa Loa (eye worm) G-protein coupled receptor 0.0269 0.0434 0.0693
Echinococcus multilocularis rhodopsin orphan GPCR 0.0269 0.0434 0.0711
Loa Loa (eye worm) neuropeptide F receptor 0.0269 0.0434 0.0693
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0116 0.2621
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.3076 0.6104 1
Loa Loa (eye worm) endoplasmin 0.014 0.0173 0.0276
Schistosoma mansoni amine GPCR 0.0269 0.0434 0.0434
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0112 0.0116 0.0186
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0391 0.0679 0.1084
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0269 0.0434 0.0434
Loa Loa (eye worm) G-protein coupled receptor 0.0269 0.0434 0.0693
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0061 0.0014 0.0086
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Toxoplasma gondii PAN domain-containing protein 0.0155 0.0203 0.0426
Loa Loa (eye worm) hypothetical protein 0.0068 0.0027 0.0044
Leishmania major heat shock protein 83-1 0.014 0.0173 0.1498
Echinococcus multilocularis rhodopsin orphan GPCR 0.0269 0.0434 0.0711
Loa Loa (eye worm) hypothetical protein 0.0068 0.0027 0.0044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0269 0.0434 0.0711
Onchocerca volvulus 0.0269 0.0434 0.2751
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Echinococcus granulosus jun protein 0.0092 0.0076 0.0124
Brugia malayi brahma associated protein 60 kDa 0.0192 0.0277 0.0442
Leishmania major heat shock protein 83-1 0.014 0.0173 0.1498
Leishmania major heat shock protein 83-1 0.014 0.0173 0.1498
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0269 0.0434 0.0434
Schistosoma mansoni retinoic acid receptor RXR 0.0061 0.0014 0.0014
Loa Loa (eye worm) pigment dispersing factor receptor c 0.2495 0.493 0.7877
Onchocerca volvulus 0.0155 0.0203 0.1285
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0269 0.0434 0.0711
Toxoplasma gondii PAN domain-containing protein 0.0155 0.0203 0.0426
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0068 0.0027 0.0057
Schistosoma mansoni protein kinase 0.0133 0.0157 0.0157
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0269 0.0434 0.0693
Echinococcus granulosus voltage dependent calcium channel 0.0166 0.0224 0.0367
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0061 0.0014 0.0014
Onchocerca volvulus 0.0155 0.0203 0.1285
Loa Loa (eye worm) hypothetical protein 0.0061 0.0014 0.0022
Schistosoma mansoni hypothetical protein 0.0312 0.0519 0.0519
Leishmania major heat shock protein 83-1 0.014 0.0173 0.1498
Loa Loa (eye worm) hypothetical protein 0.0068 0.0027 0.0044
Echinococcus granulosus dro:myosuppressin receptor 0.0269 0.0434 0.0711
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0068 0.0027 0.0402
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0269 0.0434 0.0711
Brugia malayi YY1-associated factor 2 0.0068 0.0027 0.0044
Schistosoma mansoni growth hormone secretagogue receptor 0.0269 0.0434 0.0434
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0269 0.0434 0.0711
Schistosoma mansoni fusion 0.0068 0.0027 0.0027
Onchocerca volvulus 0.0269 0.0434 0.2751
Brugia malayi Endoplasmin precursor 0.014 0.0173 0.0276
Trypanosoma brucei heat shock protein, putative 0.014 0.0173 0.2546
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0068 0.0027 0.0044
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0192 0.0277 0.0582
Loa Loa (eye worm) heat shock protein 90 0.014 0.0173 0.0276
Onchocerca volvulus 0.0155 0.0203 0.1285
Leishmania major heat shock protein 83-1 0.014 0.0173 0.1498
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0813 0.1532 0.2509
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0068 0.0027 0.0402
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0192 0.0277 0.0453
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0068 0.0027 0.0402
Loa Loa (eye worm) hypothetical protein 0.0391 0.0679 0.1084
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Echinococcus multilocularis sodium channel protein 0.0626 0.1154 0.189
Brugia malayi GnHR receptor homolog 0.0269 0.0434 0.0693
Echinococcus granulosus neuropeptide FF receptor 2 0.0728 0.1361 0.2229
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0269 0.0434 0.0711
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Entamoeba histolytica heat shock protein 90, putative 0.014 0.0173 1
Onchocerca volvulus Bile acid receptor homolog 0.0061 0.0014 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0061 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Brugia malayi hypothetical protein 0.0269 0.0434 0.0693
Toxoplasma gondii transporter, cation channel family protein 0.0166 0.0224 0.0471
Brugia malayi hypothetical protein 0.0072 0.0036 0.0057
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.0272 0.6145
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0113 0.0118 0.0193
Loa Loa (eye worm) hypothetical protein 0.0166 0.0224 0.0358
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0092 0.0076 0.0124
Brugia malayi PAN domain containing protein 0.0155 0.0203 0.0324
Trichomonas vaginalis heat shock protein, putative 0.0127 0.0146 0.3297
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0127 0.0146 1
Trypanosoma brucei Heat shock protein 83, putative 0.014 0.0173 0.2546
Echinococcus granulosus sex peptide receptor 0.0269 0.0434 0.0711
Onchocerca volvulus 0.0155 0.0203 0.1285
Brugia malayi Adenylyl cyclase protein 0.0064 0.0019 0.003
Schistosoma mansoni amine GPCR 0.0269 0.0434 0.0434
Echinococcus multilocularis voltage dependent calcium channel 0.0166 0.0224 0.0367
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0061 0.0014 0.0022
Schistosoma mansoni hypothetical protein 0.0813 0.1532 0.1532
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0115 0.0122 0.1804
Loa Loa (eye worm) bone morphogenic protein 6 0.0132 0.0157 0.025
Echinococcus granulosus G protein coupled receptor 139 0.0269 0.0434 0.0711
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0269 0.0434 0.0434
Trypanosoma brucei hypothetical protein 0.0115 0.0122 0.1804
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0192 0.0277 1
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0081 0.0054 0.2064
Leishmania major heat shock protein 83-1 0.014 0.0173 0.1498
Loa Loa (eye worm) hypothetical protein 0.0269 0.0434 0.0693
Brugia malayi neuropeptide F receptor 0.0269 0.0434 0.0693
Schistosoma mansoni neuropeptide f receptor 76f 0.0269 0.0434 0.0434
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0061 0.0014 0.0022
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0166 0.0224 0.0367
Brugia malayi Nuclear hormone receptor-like 1 0.0061 0.0014 0.0022
Echinococcus granulosus tm gpcr rhodopsin 0.1874 0.3675 0.602

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.29 nM Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1 ChEMBL. 7629811
Ki (binding) = 0.29 nM Ability to displace [125I]-AII binding to COS cells transfected with a cDNA encoding human Angiotensin II receptor, type 1 ChEMBL. 7629811

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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