Detailed information for compound 151762

Basic information

Technical information
  • TDR Targets ID: 151762
  • Name: 18-methoxycoronaridine
  • MW: 368.469 | Formula: C22H28N2O3
  • H donors: 1 H acceptors: 1 LogP: 2.68 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCC[C@@H]1CC2CN3C1[C@](C2)(C(=O)OC)c1[nH]c2c(c1CC3)cccc2
  • InChi: 1S/C22H28N2O3/c1-26-10-8-15-11-14-12-22(21(25)27-2)19-17(7-9-24(13-14)20(15)22)16-5-3-4-6-18(16)23-19/h3-6,14-15,20,23H,7-13H2,1-2H3/t14?,15-,20?,22+/m0/s1
  • InChiKey: DTJQBBHYRQYDEG-YHIIEBRDSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nAChR subunit 0.003 0.0276 0.0312
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.004 0.0401 0.0431
Loa Loa (eye worm) hypothetical protein 0.0014 0.0068 0.0073
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.003 0.0276 0.0312
Echinococcus multilocularis glycine receptor subunit beta 0.003 0.0276 0.0276
Loa Loa (eye worm) Smad1 0.005 0.0532 0.0571
Schistosoma mansoni smad 0.005 0.0532 0.0601
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.003 0.0276 0.0296
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0083 0.0956 0.3471
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0085 0.0981 0.2496
Echinococcus granulosus histone acetyltransferase KAT2B 0.0083 0.0956 0.108
Onchocerca volvulus 0.003 0.0276 0.201
Loa Loa (eye worm) hypothetical protein 0.003 0.0276 0.0296
Echinococcus granulosus snurportin 1 0.0307 0.3822 0.4318
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0315 0.0338
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0685 0.2486
Loa Loa (eye worm) hypothetical protein 0.0035 0.0341 0.0366
Plasmodium falciparum importin beta, putative 0.0029 0.0258 0.0931
Schistosoma mansoni nAChR subunit 0.003 0.0276 0.0312
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0218 0.2686 0.8958
Onchocerca volvulus 0.003 0.0276 0.201
Leishmania major polypeptide deformylase-like protein, putative 0.0085 0.0981 0.2496
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0043 0.0439 0.0472
Loa Loa (eye worm) hypothetical protein 0.0014 0.0068 0.0073
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0457 0.1159
Onchocerca volvulus 0.004 0.0401 0.2925
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.003 0.0276 0.0312
Onchocerca volvulus Matrix metalloproteinase homolog 0.0078 0.089 0.6491
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.003 0.0276 0.0296
Onchocerca volvulus 0.003 0.0276 0.201
Loa Loa (eye worm) MH2 domain-containing protein 0.005 0.0532 0.0571
Schistosoma mansoni importin beta-1 0.0029 0.0258 0.0292
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.2311 0.261
Mycobacterium leprae PROBABLE HYDROLASE 0.0043 0.0439 0.1458
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0343 0.0388
Schistosoma mansoni tar DNA-binding protein 0.0192 0.2353 0.2658
Trichomonas vaginalis esterase, putative 0.004 0.0401 0.4182
Toxoplasma gondii hypothetical protein 0.0051 0.054 0.1957
Mycobacterium ulcerans hypothetical protein 0.0166 0.2014 0.7322
Schistosoma mansoni nAChR subunit 0.0014 0.0068 0.0077
Brugia malayi Calcitonin receptor-like protein seb-1 0.0256 0.3171 0.3406
Plasmodium vivax peptide deformylase, putative 0.0223 0.2749 1
Brugia malayi glutamate synthase 0.0009 0.0003 0.0003
Plasmodium vivax thioredoxin reductase, putative 0.0096 0.1116 0.4053
Loa Loa (eye worm) hypothetical protein 0.0043 0.0439 0.0472
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0401 0.1017
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0161 0.0161
Schistosoma mansoni Smad4 0.0022 0.0177 0.02
Brugia malayi Matrixin family protein 0.0035 0.0341 0.0366
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0161 0.0182
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0003 0.0003
Loa Loa (eye worm) MH1 domain-containing protein 0.0022 0.0177 0.019
Loa Loa (eye worm) hypothetical protein 0.003 0.0276 0.0296
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0928 0.0928
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0315 0.0796
Brugia malayi Cation transporter family protein 0.003 0.0276 0.0296
Loa Loa (eye worm) hypothetical protein 0.0035 0.0341 0.0366
Loa Loa (eye worm) hypothetical protein 0.0256 0.3171 0.3406
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0492 0.6202 0.6202
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0276 0.0296
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0223 0.2749 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0189 0.2311 0.2483
Brugia malayi beta-lactamase 0.004 0.0401 0.0431
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0223 0.2749 0.8705
Brugia malayi Importin beta-1 subunit 0.0029 0.0258 0.0277
Echinococcus granulosus cpg binding protein 0.0031 0.0284 0.0321
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0218 0.2686 0.8506
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.003 0.0276 0.0296
Brugia malayi hypothetical protein 0.0014 0.0068 0.0073
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0315 0.1136
Brugia malayi hypothetical protein 0.0014 0.0068 0.0073
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0083 0.0956 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0068 0.0073
Echinococcus granulosus glycine receptor subunit beta 0.003 0.0276 0.0312
Onchocerca volvulus 0.003 0.0276 0.201
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0315 0.3273
Schistosoma mansoni ferritin 0.0018 0.0124 0.014
Loa Loa (eye worm) hypothetical protein 0.003 0.0276 0.0296
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0022 0.0177 0.1287
Treponema pallidum bacterioferrin (TpF1) 0.0018 0.0124 0.0442
Schistosoma mansoni glutamate synthase 0.0009 0.0003 0.0003
Echinococcus granulosus tar DNA binding protein 0.0192 0.2353 0.2658
Plasmodium vivax glutathione reductase, putative 0.0096 0.1116 0.4053
Brugia malayi MH2 domain containing protein 0.005 0.0532 0.0571
Loa Loa (eye worm) hypothetical protein 0.0016 0.0098 0.0105
Mycobacterium tuberculosis Conserved protein 0.004 0.0401 0.1264
Schistosoma mansoni hypothetical protein 0.005 0.053 0.0598
Schistosoma mansoni cpg binding protein 0.0031 0.0284 0.0321
Echinococcus granulosus mothers against decapentaplegic 6 0.0022 0.0177 0.02
Mycobacterium tuberculosis Probable oxidoreductase 0.0242 0.2998 0.9495
Loa Loa (eye worm) MH1 domain-containing protein 0.005 0.0532 0.0571
Loa Loa (eye worm) hypothetical protein 0.004 0.0401 0.0431
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.003 0.0276 0.0312
Loa Loa (eye worm) beta-lactamase 0.004 0.0401 0.0431
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0161 0.0173
Schistosoma mansoni smad1 5 8 and 0.005 0.0532 0.0601
Loa Loa (eye worm) hypothetical protein 0.0016 0.0098 0.0105
Schistosoma mansoni glutamate synthase 0.0009 0.0003 0.0003
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0124 0.0442
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0315 0.1136
Schistosoma mansoni hypothetical protein 0.0256 0.317 0.3581
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0014 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0014 0.0068 0.0073
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.003 0.0276 0.0296
Entamoeba histolytica hypothetical protein 0.0016 0.0098 0.1101
Loa Loa (eye worm) hypothetical protein 0.0014 0.0068 0.0073
Brugia malayi Matrixin family protein 0.0035 0.0341 0.0366
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0315 0.0796
Loa Loa (eye worm) hypothetical protein 0.004 0.0401 0.0431
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0928 0.0997
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0014 0.0068 0.0077
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.003 0.0276 0.0296
Loa Loa (eye worm) hypothetical protein 0.003 0.0276 0.0296
Plasmodium falciparum glutathione reductase 0.0096 0.1116 0.4053
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0315 0.0796
Onchocerca volvulus 0.0009 0.0003 0.0017
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0009 0.0003 0.0003
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0315 0.1136
Echinococcus granulosus ferritin 0.0018 0.0124 0.014
Loa Loa (eye worm) nuclear factor I 0.0028 0.0245 0.0263
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0014 0.0068 0.0068
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.003 0.0276 0.0296
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0581 0.1475
Schistosoma mansoni hypothetical protein 0.0035 0.0343 0.0388
Loa Loa (eye worm) programmed cell death 8 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.004 0.0401 0.0431
Chlamydia trachomatis peptide deformylase 0.0223 0.2749 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0315 0.0796
Brugia malayi MH1 domain containing protein 0.0028 0.0245 0.0263
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0457 0.1159
Loa Loa (eye worm) hypothetical protein 0.0022 0.0177 0.019
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0161 0.0173
Brugia malayi MH2 domain containing protein 0.0735 0.9309 1
Schistosoma mansoni ferritin light chain 0.0018 0.0124 0.014
Leishmania major importin beta-1 subunit, putative 0.0023 0.0189 0.0474
Plasmodium falciparum thioredoxin reductase 0.0033 0.0315 0.1136
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0315 0.0989
Loa Loa (eye worm) hypothetical protein 0.0175 0.2133 0.2291
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0401 0.1264
Loa Loa (eye worm) hypothetical protein 0.0016 0.0098 0.0105
Plasmodium vivax hypothetical protein, conserved 0.004 0.0401 0.1452
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.003 0.0276 0.0312
Onchocerca volvulus 0.0014 0.0068 0.0493
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.003 0.0276 0.0296
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0401 0.0453
Schistosoma mansoni apoferritin-2 0.0018 0.0124 0.014
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0401 0.1264
Echinococcus multilocularis glycine receptor subunit alpha 1 0.003 0.0276 0.0276
Schistosoma mansoni tar DNA-binding protein 0.0192 0.2353 0.2658
Brugia malayi MH2 domain containing protein 0.005 0.0532 0.0571
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0014 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.003 0.0276 0.0296
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.2311 0.261
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0492 0.6202 0.6202
Mycobacterium tuberculosis Probable reductase 0.0218 0.2686 0.8506
Echinococcus multilocularis glutamate synthase 0.0009 0.0003 0.0003
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0085 0.0981 0.2496
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0009 0.0003 0.0003
Schistosoma mansoni nAChR subunit 0.003 0.0276 0.0312
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0242 0.2998 0.9495
Loa Loa (eye worm) RNA binding protein 0.0192 0.2353 0.2528
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0315 0.0796
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0315 0.3922 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.005 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.0014 0.0068 0.0073
Loa Loa (eye worm) LGC-31 protein 0.003 0.0276 0.0296
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0116 0.1372 0.1372
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.003 0.0276 0.0312
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0276 0.0296
Echinococcus multilocularis mothers against decapentaplegic 2 0.0022 0.0177 0.0177
Toxoplasma gondii thioredoxin reductase 0.0096 0.1116 0.4053
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0016 0.0098 0.0105
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0014 0.0068 0.0073
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0116 0.1372 0.1372
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0315 0.0796
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0.0124 0.0442
Onchocerca volvulus 0.004 0.0401 0.2925
Loa Loa (eye worm) hypothetical protein 0.003 0.0276 0.0296
Onchocerca volvulus 0.003 0.0276 0.201
Schistosoma mansoni alkaline phosphatase 0.0492 0.6202 0.7006
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0401 0.1017
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0003 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.2311 0.261
Echinococcus multilocularis snurportin 1 0.0307 0.3822 0.3822
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0315 0.0315
Brugia malayi acetyltransferase, GNAT family protein 0.0283 0.3515 0.3776
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.003 0.0276 0.0296
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0401 0.4182
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0492 0.6202 0.6202
Echinococcus multilocularis mothers against decapentaplegic 6 0.0022 0.0177 0.0177
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0401 0.0453
Schistosoma mansoni ferritin 0.0018 0.0124 0.014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0098 0.0105
Onchocerca volvulus 0.0014 0.0068 0.0493
Schistosoma mansoni tar DNA-binding protein 0.0192 0.2353 0.2658
Onchocerca volvulus 0.004 0.0401 0.2925
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0016 0.0098 0.0105
Entamoeba histolytica hypothetical protein 0.0035 0.0343 0.3937
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.003 0.0276 0.0296
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0035 0.0341 0.0385
Echinococcus granulosus GPCR family 2 0.0081 0.0928 0.1048
Loa Loa (eye worm) ACC-1 protein 0.003 0.0276 0.0296
Schistosoma mansoni hypothetical protein 0.0081 0.0928 0.1048
Schistosoma mansoni Smad4 0.0022 0.0177 0.02
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0005 0.0005
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.003 0.0276 0.0312
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0014 0.0068 0.0073
Entamoeba histolytica Ran family GTPase 0.0021 0.0161 0.1832
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0343 0.0388
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0016 0.0098 0.0105
Echinococcus granulosus tm gpcr rhodopsin 0.0634 0.8013 0.9051
Echinococcus multilocularis smad 0.005 0.0532 0.0532
Brugia malayi glutathione reductase 0.0096 0.1116 0.1199
Mycobacterium tuberculosis Conserved protein 0.004 0.0401 0.1264
Schistosoma mansoni alkaline phosphatase 0.0492 0.6202 0.7006
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0083 0.0956 0.3471
Brugia malayi MH1 domain containing protein 0.0028 0.0245 0.0263
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0016 0.0098 0.0105
Echinococcus multilocularis Smad4 0.005 0.0532 0.0532
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0009 0.0003 0.0003
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0315 0.0796
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0068 0.0073
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0276 0.0296
Loa Loa (eye worm) hypothetical protein 0.0014 0.0068 0.0073
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.2311 0.2311
Echinococcus multilocularis nAChR subunit 0.003 0.0276 0.0276
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.003 0.0276 0.0296
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0009 0.0003 0.0003
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0315 0.3922 1
Echinococcus granulosus alkaline phosphatase 0.0492 0.6202 0.7006
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0149 0.1798 0.4581
Giardia lamblia Histone acetyltransferase GCN5 0.0076 0.0867 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0256 0.3171 0.3406
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.003 0.0276 0.0296
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0018 0.0124 0.0406
Echinococcus granulosus microtubule associated protein 2 0.0699 0.8853 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0315 0.0796
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0004 0.0004
Schistosoma mansoni apoferritin-2 0.0018 0.0124 0.014
Trichomonas vaginalis ferritin, putative 0.0018 0.0124 0.1275
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0242 0.2998 0.9495
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0276 0.0296
Schistosoma mansoni neurotransmitter gated ion channel 0.0014 0.0068 0.0077
Loa Loa (eye worm) hypothetical protein 0.0014 0.0068 0.0073
Loa Loa (eye worm) hypothetical protein 0.003 0.0276 0.0296
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0016 0.0098 0.0111
Loa Loa (eye worm) hypothetical protein 0.003 0.0276 0.0296
Schistosoma mansoni ferritin light chain 0.0018 0.0124 0.014
Brugia malayi Smad1 0.005 0.0532 0.0571
Trypanosoma cruzi trypanothione reductase, putative 0.0096 0.1116 0.284
Loa Loa (eye worm) hypothetical protein 0.0016 0.0098 0.0105
Schistosoma mansoni nAChR subunit 0.003 0.0276 0.0312
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0315 0.3922 1
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0014 0.0068 0.0073
Echinococcus granulosus nAChR subunit 0.0016 0.0098 0.0111
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0492 0.6202 0.7006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0068 0.0073
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0315 0.3273
Schistosoma mansoni hypothetical protein 0.0307 0.3822 0.4318
Brugia malayi latrophilin 2 splice variant baaae 0.0175 0.2133 0.2291
Echinococcus granulosus smad 0.005 0.0532 0.0601
Echinococcus granulosus glycine receptor subunit beta 0.003 0.0276 0.0312
Echinococcus multilocularis glycine receptor subunit beta 0.003 0.0276 0.0276
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0218 0.2686 0.8506
Loa Loa (eye worm) hypothetical protein 0.0016 0.0098 0.0105
Schistosoma mansoni tar DNA-binding protein 0.0192 0.2353 0.2658
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0276 0.0296
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.003 0.0276 0.0276
Loa Loa (eye worm) GABA receptor subunit 0.0016 0.0098 0.0105
Loa Loa (eye worm) acetylcholine receptor protein 0.0014 0.0068 0.0073
Brugia malayi hypothetical protein 0.0035 0.0343 0.0369
Echinococcus granulosus nAChR subunit 0.003 0.0276 0.0312
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.003 0.0276 0.0312
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.1798 0.4581
Onchocerca volvulus 0.0014 0.0068 0.0493
Treponema pallidum polypeptide deformylase (def) 0.0223 0.2749 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0283 0.3515 0.3971
Leishmania major hypothetical protein, conserved 0.004 0.0401 0.1017
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0401 0.0401
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0315 0.0796
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0161 0.0404
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0634 0.8013 0.8013
Schistosoma mansoni TGF-beta signal transducer Smad2 0.005 0.0532 0.0601
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0401 0.1264
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0401 0.0453
Trypanosoma brucei Peptide deformylase 2 0.0085 0.0981 0.2496
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0003 0.0003
Schistosoma mansoni nAChR subunit 0.0014 0.0068 0.0077
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0068 0.0073
Schistosoma mansoni glutamate synthase 0.0009 0.0003 0.0003
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.0003 0.0003
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0014 0.0068 0.0077
Schistosoma mansoni smad 0.0022 0.0177 0.02
Schistosoma mansoni nAChR subunit 0.003 0.0276 0.0312
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0009 0.0003 0.0003
Brugia malayi RNA, U transporter 1 0.0082 0.0937 0.1007
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0315 0.1136
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0189 0.0474
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0223 0.2749 0.9169
Echinococcus granulosus intestinal type alkaline phosphatase 0.0492 0.6202 0.7006
Brugia malayi RNA recognition motif domain containing protein 0.0192 0.2353 0.2528
Entamoeba histolytica hypothetical protein 0.0023 0.0189 0.2151
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0401 0.1264
Mycobacterium leprae conserved hypothetical protein 0.004 0.0401 0.1331
Echinococcus multilocularis tar DNA binding protein 0.0192 0.2353 0.2353
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0189 0.195
Loa Loa (eye worm) hypothetical protein 0.0014 0.0068 0.0073
Trypanosoma brucei trypanothione reductase 0.0096 0.1116 0.284
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0124 0.0385
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0928 0.1048
Entamoeba histolytica hypothetical protein 0.0035 0.0343 0.3937
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0315 0.0796
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0315 0.1136
Onchocerca volvulus 0.0016 0.0098 0.0711
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0009 0.0003 0.0003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0681 0.0769
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0161 0.0577
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0315 0.3609
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0242 0.2998 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0315 0.1136
Brugia malayi excitatory GABA receptor EXP-1A 0.003 0.0276 0.0296
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0189 0.195
Loa Loa (eye worm) matrixin family protein 0.0085 0.0981 0.1054
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0928 0.0997
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0315 0.0796
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0315 0.1136
Schistosoma mansoni acetylcholine receptor subunit beta 0.0014 0.0068 0.0077
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0161 0.0577
Schistosoma mansoni hypothetical protein 0.0081 0.0928 0.1048
Echinococcus multilocularis expressed protein 0.0018 0.0124 0.0124
Plasmodium vivax importin-beta 2, putative 0.0029 0.0258 0.0931
Schistosoma mansoni hypothetical protein 0.0081 0.0928 0.1048
Onchocerca volvulus Putative nachr subunit 0.0116 0.1372 1
Onchocerca volvulus 0.0035 0.0341 0.2485
Schistosoma mansoni cpg binding protein 0.0031 0.0284 0.0321
Brugia malayi Matrixin family protein 0.0035 0.0341 0.0366
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0116 0.1372 0.1474
Trichomonas vaginalis bromodomain-containing protein, putative 0.0083 0.0956 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0116 0.1372 0.1474
Schistosoma mansoni cpg binding protein 0.0029 0.0263 0.0297
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0116 0.1372 0.1372
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0401 0.1264
Brugia malayi MH1 domain containing protein 0.005 0.0532 0.0571
Mycobacterium tuberculosis Conserved hypothetical protein 0.0166 0.2014 0.6374
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0315 0.1136
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0189 0.195
Loa Loa (eye worm) hypothetical protein 0.0014 0.0068 0.0073
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0401 0.0431
Loa Loa (eye worm) hypothetical protein 0.003 0.0276 0.0296
Loa Loa (eye worm) hypothetical protein 0.0014 0.0068 0.0073
Loa Loa (eye worm) hypothetical protein 0.0016 0.0098 0.0105
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0315 0.0796
Echinococcus granulosus thioredoxin glutathione reductase 0.0096 0.1116 0.126
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0401 0.4182
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0218 0.2686 0.8506
Schistosoma mansoni smad1 5 8 and 0.005 0.0532 0.0601
Loa Loa (eye worm) transcription factor SMAD2 0.0735 0.9309 1
Echinococcus multilocularis microtubule associated protein 2 0.0699 0.8853 0.8853
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.003 0.0276 0.0276
Brugia malayi beta-lactamase family protein 0.004 0.0401 0.0431
Schistosoma mansoni ferritin 0.0018 0.0124 0.014
Loa Loa (eye worm) matrixin family protein 0.0078 0.089 0.0957
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0009 0.0003 0.0003
Echinococcus granulosus glycine receptor subunit alpha 1 0.003 0.0276 0.0312
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.003 0.0276 0.0312
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0258 0.0652
Entamoeba histolytica acetyltransferase, GNAT family 0.0076 0.0867 1
Plasmodium falciparum peptide deformylase 0.0223 0.2749 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0928 0.0997
Brugia malayi hypothetical protein 0.0014 0.0068 0.0073
Schistosoma mansoni tar DNA-binding protein 0.0192 0.2353 0.2658
Schistosoma mansoni disulfide oxidoreductase 0.0009 0.0003 0.0003
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0258 0.0931
Mycobacterium tuberculosis Conserved protein 0.004 0.0401 0.1264
Echinococcus granulosus TGF beta signal transducer SmadC 0.005 0.0532 0.0601
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0928 0.1048
Loa Loa (eye worm) hypothetical protein 0.003 0.0276 0.0296
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0315 0.0356
Loa Loa (eye worm) hypothetical protein 0.0016 0.0098 0.0105
Treponema pallidum NADH oxidase 0.0033 0.0315 0.1136
Loa Loa (eye worm) thioredoxin reductase 0.0096 0.1116 0.1199
Entamoeba histolytica hypothetical protein 0.0035 0.0343 0.3937
Mycobacterium ulcerans peptide deformylase 0.0223 0.2749 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0003
Leishmania major GTP-binding protein, putative 0.0021 0.0161 0.0404
Schistosoma mansoni smad1 5 8 and 0.005 0.0532 0.0601
Schistosoma mansoni neurotransmitter gated ion channel 0.0016 0.0098 0.0111
Echinococcus granulosus importin subunit beta 1 0.0029 0.0258 0.0292
Brugia malayi mothers against decapentaplegic homolog 3 0.0022 0.0177 0.019
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0343 0.0343
Loa Loa (eye worm) hypothetical protein 0.003 0.0276 0.0296
Echinococcus granulosus mothers against decapentaplegic 5 0.005 0.0532 0.0601
Plasmodium falciparum histone acetyltransferase GCN5 0.0076 0.0867 0.3148
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0084 0.0961 0.1086
Trypanosoma cruzi Peptide deformylase 2, putative 0.0085 0.0981 0.2496
Brugia malayi Hemopexin family protein 0.005 0.053 0.0569
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0315 0.0796
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0492 0.6202 0.7006
Mycobacterium ulcerans hydrolase 0.0043 0.0439 0.159
Loa Loa (eye worm) hypothetical protein 0.0014 0.0068 0.0073
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.003 0.0276 0.0312
Loa Loa (eye worm) ACC-1 protein 0.003 0.0276 0.0296
Echinococcus granulosus glutamate synthase 0.0009 0.0003 0.0003
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0124 0.0385
Schistosoma mansoni nAChR subunit 0.003 0.0276 0.0312
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.2311 0.261
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0009 0.0003 0.0003
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0161 0.0404
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0116 0.1372 0.1549
Schistosoma mansoni ferritin 0.0018 0.0124 0.014
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0315 0.1136
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0256 0.3171 0.3406
Loa Loa (eye worm) hypothetical protein 0.0035 0.0341 0.0366
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0192 0.2353 0.2528
Loa Loa (eye worm) hypothetical protein 0.003 0.0276 0.0296
Schistosoma mansoni hypothetical protein 0.0175 0.2133 0.2409
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.3822 0.4106
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0003 0.0003
Brugia malayi Cation transporter family protein 0.003 0.0276 0.0296
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0202 0.0217
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0401 0.1452
Loa Loa (eye worm) hypothetical protein 0.003 0.0276 0.0296
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0255 0.3158 1
Brugia malayi beta-lactamase family protein 0.004 0.0401 0.0431
Schistosoma mansoni Smad4 0.005 0.0532 0.0601
Echinococcus multilocularis mothers against decapentaplegic 5 0.005 0.0532 0.0532
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.003 0.0276 0.0296
Brugia malayi MH1 domain containing protein 0.005 0.0532 0.0571
Mycobacterium ulcerans hypothetical protein 0.004 0.0401 0.1452
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.003 0.0276 0.0276
Mycobacterium ulcerans beta-lactamase 0.004 0.0401 0.1452
Loa Loa (eye worm) TAR-binding protein 0.0192 0.2353 0.2528
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0401 0.1452
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0003 0.0003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0315 0.0796
Schistosoma mansoni hypothetical protein 0.0081 0.0928 0.1048
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0128 0.153 0.153
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0009 0.0003 0.0003
Schistosoma mansoni acetylcholine receptor-related 0.0014 0.0068 0.0077
Loa Loa (eye worm) hypothetical protein 0.0016 0.0098 0.0105
Echinococcus multilocularis alkaline phosphatase 0.0492 0.6202 0.6202
Echinococcus granulosus glycine receptor subunit alpha 1 0.003 0.0276 0.0312
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0315 0.0796
Mycobacterium leprae Probable lipase LipE 0.004 0.0401 0.1331
Schistosoma mansoni microtubule-associated protein tau 0.0699 0.8853 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.003 0.0276 0.0276
Trypanosoma cruzi Peptide deformylase 2, putative 0.0085 0.0981 0.2496
Loa Loa (eye worm) hypothetical protein 0.0029 0.0258 0.0277
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0083 0.0956 0.3471
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0315 0.1136
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0457 0.1159
Toxoplasma gondii ABC1 family protein 0.004 0.0401 0.1452
Onchocerca volvulus 0.003 0.0276 0.201
Loa Loa (eye worm) hypothetical protein 0.004 0.0401 0.0431
Brugia malayi Matrixin family protein 0.0085 0.0981 0.1054
Echinococcus granulosus expressed protein 0.0018 0.0124 0.014
Leishmania major trypanothione reductase 0.0096 0.1116 0.284
Echinococcus multilocularis GPCR, family 2 0.0081 0.0928 0.0928
Loa Loa (eye worm) hypothetical protein 0.0028 0.0245 0.0263
Plasmodium falciparum thioredoxin reductase 0.0096 0.1116 0.4053
Echinococcus granulosus Smad4 0.005 0.0532 0.0601
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0043 0.0439 0.1384
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0263 0.0282
Echinococcus multilocularis thioredoxin glutathione reductase 0.0096 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0014 0.0068 0.0073
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0258 0.0652
Brugia malayi CXXC zinc finger family protein 0.0029 0.0263 0.0282
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0116 0.1372 0.1549
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0315 0.1136
Echinococcus multilocularis cpg binding protein 0.0031 0.0284 0.0284
Loa Loa (eye worm) glutathione reductase 0.0096 0.1116 0.1199
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0161 0.0404
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0161 0.0577
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.003 0.0276 0.0312
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.003 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.003 0.0276 0.0296
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0005 0.0006
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0928 0.0997
Loa Loa (eye worm) hypothetical protein 0.003 0.0276 0.0296
Leishmania major mitochondrial DNA polymerase beta 0.0315 0.3922 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0401 0.0431
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0014 0.0068 0.0073
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0005 0.0006
Echinococcus granulosus mothers against decapentaplegic 2 0.0022 0.0177 0.02
Brugia malayi TAR-binding protein 0.0192 0.2353 0.2528
Brugia malayi Matrixin family protein 0.0035 0.0341 0.0366
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0003 0.0003
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.003 0.0276 0.0296
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0096 0.1116 0.3528
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0128 0.153 0.1728
Onchocerca volvulus Matrilysin homolog 0.0078 0.089 0.6491
Brugia malayi Thioredoxin reductase 0.0096 0.1116 0.1199
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0315 0.1136
Echinococcus granulosus glycine receptor subunit alpha 1 0.003 0.0276 0.0312
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.2311 0.2311
Loa Loa (eye worm) hypothetical protein 0.0116 0.1372 0.1474
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.1798 0.4581
Loa Loa (eye worm) MH2 domain-containing protein 0.0735 0.9309 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0022 0.0177 0.019
Echinococcus multilocularis nAChR subunit 0.0016 0.0098 0.0098
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0401 0.1264
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.003 0.0276 0.0296
Echinococcus granulosus histone acetyltransferase KAT2B 0.0275 0.3414 0.3856
Mycobacterium tuberculosis Probable dehydrogenase 0.0218 0.2686 0.8506
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0189 0.2311 0.2483
Onchocerca volvulus 0.005 0.053 0.3859
Trichomonas vaginalis ran, putative 0.0021 0.0161 0.1661
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0401 0.4182
Loa Loa (eye worm) hypothetical protein 0.0014 0.0068 0.0073
Schistosoma mansoni nAChR subunit 0.003 0.0276 0.0312
Loa Loa (eye worm) matrix metalloproteinase 0.0035 0.0341 0.0366
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0401 0.0431
Schistosoma mansoni ran 0.0021 0.0161 0.0182
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0315 0.0356
Echinococcus multilocularis glycine receptor subunit alpha 1 0.003 0.0276 0.0276
Onchocerca volvulus Matrilysin homolog 0.0035 0.0341 0.2485
Onchocerca volvulus 0.0016 0.0098 0.0711
Brugia malayi hypothetical protein 0.0014 0.0068 0.0073
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.003 0.0276 0.0296
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0202 0.0217
Loa Loa (eye worm) hypothetical protein 0.003 0.0276 0.0296
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0161 0.1832
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0401 0.1264
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0124 0.0442
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0283 0.3515 0.3515
Loa Loa (eye worm) hypothetical protein 0.003 0.0276 0.0296
Mycobacterium ulcerans lipase LipD 0.004 0.0401 0.1452
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0116 0.1372 0.1549
Loa Loa (eye worm) hypothetical protein 0.0014 0.0068 0.0073
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0315 0.0796
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0401 0.4182
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0457 0.1159
Onchocerca volvulus 0.0029 0.0263 0.1915
Schistosoma mansoni neurotransmitter gated ion channel 0.0014 0.0068 0.0077
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0009 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0003
Trypanosoma brucei Polypeptide deformylase 1 0.0085 0.0981 0.2496
Echinococcus multilocularis ferritin 0.0018 0.0124 0.0124
Brugia malayi MH2 domain containing protein 0.0022 0.0177 0.019
Loa Loa (eye worm) acetyltransferase 0.0283 0.3515 0.3776
Schistosoma mansoni ran 0.0021 0.0161 0.0182
Plasmodium falciparum glutathione reductase 0.0033 0.0315 0.1136
Entamoeba histolytica hypothetical protein 0.0035 0.0343 0.3937
Brugia malayi Cation transporter family protein 0.003 0.0276 0.0296
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0016 0.0098 0.0111
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0315 0.0796
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0401 0.1017
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0014 0.0068 0.0073
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0928 0.0928
Brugia malayi hypothetical protein 0.0014 0.0068 0.0073
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0401 0.4182
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.003 0.0276 0.0296
Toxoplasma gondii hypothetical protein 0.0223 0.2749 1
Brugia malayi RNA binding protein 0.0192 0.2353 0.2528
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.003 0.0276 0.0312
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.2311 0.261
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0218 0.2686 0.8506

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 20 % Inhibition of [3H]U69,593 binding to Opioid receptor kappa 1 from guinea pig brain membranes ChEMBL. 12801235
Inhibition (binding) = 35 % Inhibition of [3H]-naltrindole binding to Opioid receptor delta 1 in guinea pig brain membranes ChEMBL. 12801235
Inhibition (binding) = 50 % Inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 from guinea pig brain membranes ChEMBL. 12801235
Inhibition (functional) = 98 % Inhibition of Ach evoked currents at Nicotinic acetylcholine receptor alpha3-beta4 by 20 uM concentration ChEMBL. 12801235
Ki (binding) = 0.7 uM Binding affinity towards Nicotinic acetylcholine receptor alpha3-beta4 determined from kinetic measures of koff/kon ChEMBL. 12801235
Ki (binding) = 1.1 uM Binding affinity was determined against Opioid receptor mu 1 from guinea pig brain membranes ChEMBL. 12801235
Ki (binding) = 3.5 uM Binding affinity was determined against Opioid receptor delta 1 from guinea pig brain membranes ChEMBL. 12801235
Ki (binding) = 5.1 uM Binding affinity was determined against Opioid receptor kappa 1 from guinea pig brain membranes ChEMBL. 12801235
Rate of inhibition (functional) = 5.5 s-1 Rate of inhibition of Ach evoked currents at Nicotinic acetylcholine receptor alpha3-beta4 by 20 uM concentration ChEMBL. 12801235
Recovery (functional) = 12 % Recovery from Ach evoked currents at Nicotinic acetylcholine receptor alpha3-beta4 at 20 uM concentration ChEMBL. 12801235
RI (functional) = 1 Relative inhibition index (RI) was determined as the %recovery/(rate of inhibition) and is expressed relative to Compound 3 ChEMBL. 12801235

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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