Detailed information for compound 1518665

Basic information

Technical information
  • TDR Targets ID: 1518665
  • Name: 2-[(4-chlorophenyl)methylamino]-N-(2-chloro-5 -pyrrolidin-1-ylsulfonylphenyl)acetamide; oxa lic acid
  • MW: 532.394 | Formula: C21H23Cl2N3O7S
  • H donors: 4 H acceptors: 7 LogP: 0.56 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(=O)O.O=C(Nc1cc(ccc1Cl)S(=O)(=O)N1CCCC1)CNCc1ccc(cc1)Cl
  • InChi: 1S/C19H21Cl2N3O3S.C2H2O4/c20-15-5-3-14(4-6-15)12-22-13-19(25)23-18-11-16(7-8-17(18)21)28(26,27)24-9-1-2-10-24;3-1(4)2(5)6/h3-8,11,22H,1-2,9-10,12-13H2,(H,23,25);(H,3,4)(H,5,6)
  • InChiKey: NNJXIEOZIWWUFP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(4-chlorophenyl)methylamino]-N-(2-chloro-5-pyrrolidin-1-ylsulfonyl-phenyl)acetamide; oxalic acid
  • 2-[(4-chlorophenyl)methylamino]-N-(2-chloro-5-1-pyrrolidinylsulfonylphenyl)acetamide; oxalic acid
  • 2-[(4-chlorobenzyl)amino]-N-(2-chloro-5-pyrrolidin-1-ylsulfonyl-phenyl)acetamide; oxalic acid
  • 2-[(4-chlorophenyl)methylamino]-N-(2-chloro-5-pyrrolidin-1-ylsulfonyl-phenyl)ethanamide; ethanedioic acid
  • T0518-3596

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-lactamase family protein 0.0041 0.029 0.1273
Loa Loa (eye worm) hypothetical protein 0.0041 0.029 0.0972
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0042 0.025
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0172 0.1601 0.1601
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0115 0.0385
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0068 0.0972
Loa Loa (eye worm) hypothetical protein 0.0027 0.0146 0.049
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0922 0.9127 0.9127
Trichomonas vaginalis Heterochromatin protein, putative 0.0014 0.0017 0.0234
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0042 0.0141
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.029 0.3912
Brugia malayi Associated with TFs and helicases family protein 0.0014 0.0017 0.0076
Echinococcus multilocularis geminin 0.0169 0.1578 0.1578
Echinococcus granulosus lipoxygenase domain containing protein 0.0179 0.1678 0.1678
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0051 0.0388 0.5578
Toxoplasma gondii cell division protein CDC48AP 0.0051 0.0395 0.533
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0497 0.0497
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0052 0.0404 0.0404
Onchocerca volvulus Chorion peroxidase homolog 0.0027 0.0146 0.087
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0122 0.1108 0.3716
Schistosoma mansoni hypothetical protein 0.0051 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0058
Schistosoma mansoni loxhd1 0.0179 0.1678 0.1678
Leishmania major trypanothione reductase 0.0047 0.0349 0.5008
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.107 1
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.029 0.4161
Schistosoma mansoni hypothetical protein 0.0019 0.007 0.007
Schistosoma mansoni hypothetical protein 0.004 0.0284 0.0284
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.029 0.0972
Echinococcus multilocularis RUN 0.0179 0.1678 0.1678
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0349 0.0349
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0017 0.0234
Schistosoma mansoni hypothetical protein 0.004 0.0284 0.0284
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0014 0.0017 0.0104
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.2964 0.9944
Echinococcus multilocularis peroxidasin 0.0027 0.0146 0.0146
Brugia malayi Protein kinase domain containing protein 0.0052 0.0404 0.1775
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.095 0.3188
Brugia malayi jmjC domain containing protein 0.0115 0.1036 0.4551
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.029 0.0972
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0052 0.0404 0.1355
Brugia malayi M-phase phosphoprotein, mpp8 0.0014 0.0017 0.0076
Echinococcus granulosus lysine specific demethylase 5A 0.0044 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.0041 0.029 0.0972
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.2277 0.7638
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0014 0.0024 0.0024
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0042 0.0141
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0162 0.1507 0.1507
Echinococcus granulosus lipoxygenase domain containing protein 0.0179 0.1678 0.1678
Onchocerca volvulus 0.0179 0.1678 1
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0081 0.0696 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0052 0.0404 0.0404
Echinococcus granulosus Chromobox protein 3 0.0014 0.0017 0.0017
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0068 0.0297
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.006 0.0485 0.1627
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0185
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.002 0.0083 0.1119
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0609 0.2042
Schistosoma mansoni protein kinase 0.0173 0.1617 0.1617
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0146 0.049
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0017 0.0104
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0315 0.0315
Schistosoma mansoni hypothetical protein 0.0043 0.0315 0.0315
Loa Loa (eye worm) hypothetical protein 0.0041 0.029 0.0972
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0602
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0349 0.5008
Mycobacterium ulcerans lipase LipD 0.0041 0.029 0.0972
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0168 0.227
Schistosoma mansoni serine/threonine protein kinase 0.0162 0.1507 0.1507
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0058
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.029 0.0972
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0083 0.1126
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0083 0.1126
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0017 0.0234
Plasmodium falciparum glutathione reductase 0.0047 0.0349 0.2079
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0323 0.1085
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.029 0.0972
Echinococcus multilocularis lipoxygenase domain containing protein 0.0179 0.1678 0.1678
Onchocerca volvulus 0.0051 0.0388 0.2316
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0183 0.1718 0.1718
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0042 0.0602
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0114 0.163
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0042 0.0602
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0034 0.0114
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0404 0.0404
Schistosoma mansoni vam6/vps39 related 0.0051 0.0388 0.0388
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0055 0.0185
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0299 0.0299
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0323 0.0323
Plasmodium vivax multidomain scavenger receptor, putative 0.0179 0.1678 1
Echinococcus granulosus RUN 0.0179 0.1678 0.1678
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1326 0.4448
Brugia malayi Thioredoxin reductase 0.0047 0.0349 0.1532
Brugia malayi Heterochromatin protein 1 0.0084 0.0723 0.3177
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0014 0.0017 0.0104
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.095 0.3188
Trichomonas vaginalis hypothetical protein 0.0014 0.0017 0.0234
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0017 0.0017
Brugia malayi Protein kinase domain containing protein 0.0162 0.1507 0.662
Echinococcus granulosus importin subunit beta 1 0.0029 0.0168 0.0168
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0036 0.0235 0.0235
Schistosoma mansoni hypothetical protein 0.0414 0.403 0.403
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0185
Brugia malayi Importin beta-1 subunit 0.0029 0.0168 0.0739
Brugia malayi follicle stimulating hormone receptor 0.0239 0.2277 1
Loa Loa (eye worm) glutathione reductase 0.0047 0.0349 0.117
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0602
Echinococcus multilocularis protein dispatched 1 0.0048 0.0358 0.0358
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0171 0.0572
Schistosoma mansoni ap endonuclease 0.0019 0.0068 0.0068
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.029 0.0972
Entamoeba histolytica cdc48-like protein, putative 0.0081 0.0696 0.2336
Loa Loa (eye worm) hypothetical protein 0.0042 0.0299 0.1002
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0081 0.0696 0.0696
Schistosoma mansoni protein kinase 0.0122 0.1108 0.1108
Schistosoma mansoni protein kinase 0.0052 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0027 0.0146 0.049
Echinococcus granulosus peroxidasin 0.0027 0.0146 0.0146
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.095 0.3188
Mycobacterium tuberculosis Putative conserved ATPase 0.0051 0.0395 0.1324
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0014 0.0017 0.0076
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0042 0.0602
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0068 0.073
Echinococcus multilocularis Chromobox protein 3 0.0014 0.0017 0.0017
Echinococcus multilocularis chromobox protein 2 0.0014 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0027 0.0146 0.049
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0115 0.0385
Loa Loa (eye worm) hypothetical protein 0.0097 0.0857 0.2875
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0083 0.1126
Echinococcus granulosus chromobox protein 1 0.0084 0.0723 0.0723
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0185
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0115 0.0385
Loa Loa (eye worm) beta-lactamase 0.0041 0.029 0.0972
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0017 0.0058
Plasmodium vivax cell division cycle ATPase, putative 0.0031 0.0191 0.1139
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0185
Schistosoma mansoni ap endonuclease 0.0019 0.0068 0.0068
Trichomonas vaginalis proteasome-activating nucleotidase, putative 0.002 0.0083 0.1119
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0483 0.2122
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0067 0.0067
Loa Loa (eye worm) blistered cuticle protein 3 0.0027 0.0146 0.049
Brugia malayi hypothetical protein 0.0027 0.0146 0.0641
Brugia malayi Latrophilin receptor protein 2 0.0019 0.007 0.0309
Schistosoma mansoni hypothetical protein 0.0179 0.1678 0.1678
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0017 0.0234
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0232 0.3138
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0162 0.1507 0.5057
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0115 0.0385
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0232 0.078
Entamoeba histolytica hypothetical protein 0.0043 0.0315 0.1057
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0857 0.0857
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.007 0.0236
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0168 0.2415
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0236
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.095 0.8749
Onchocerca volvulus 0.0027 0.0146 0.087
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0146 0.0641
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0017 0.0234
Schistosoma mansoni rap gtpase-activating protein 0.0051 0.0388 0.0388
Brugia malayi chromobox protein homolog 3 0.0047 0.0352 0.1548
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.007 0.0309
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0052 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0172 0.1601 0.5372
Schistosoma mansoni microtubule-associated protein tau 0.0698 0.6882 0.6882
Echinococcus granulosus Chromo domain 0.0014 0.0017 0.0017
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0068 0.0972
Toxoplasma gondii cell division protein CDC48CY 0.0086 0.0741 1
Entamoeba histolytica hypothetical protein 0.0043 0.0315 0.1057
Brugia malayi hypothetical protein 0.0179 0.1678 0.7367
Entamoeba histolytica hypothetical protein 0.0014 0.0017 0.0058
Echinococcus granulosus chromobox protein 1 0.0084 0.0723 0.0723
Plasmodium falciparum phd finger protein, putative 0.0035 0.0232 0.1386
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0115 0.0503
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0051 0.0388 0.0388
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0872 0.0872
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0323 0.0323
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.029 0.3912
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0068 1
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.029 0.4161
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0723 0.2427
Trypanosoma brucei Valosin-containing protein 0.0081 0.0696 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0042 0.025
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0183 0.1718 0.5762
Brugia malayi Doublecortin family protein 0.0179 0.1678 0.7367
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0146 0.0641
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0349 0.117
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0034 0.0034
Leishmania major hypothetical protein, conserved 0.0041 0.029 0.4161
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0042 0.0602
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0115 0.0385
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0857 0.3763
Plasmodium falciparum heterochromatin protein 1 0.0014 0.0017 0.0104
Loa Loa (eye worm) hypothetical protein 0.0027 0.0146 0.049
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.029 0.029
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.107 0.3589
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.029 0.029
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0179 0.1678 0.5627
Schistosoma mansoni hypothetical protein 0.0019 0.007 0.007
Onchocerca volvulus Dual oxidase homolog 0.0027 0.0146 0.087
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0602
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0371 0.0371
Schistosoma mansoni hypothetical protein 0.0307 0.2964 0.2964
Onchocerca volvulus 0.0041 0.029 0.1727
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0017 0.0234
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0115 0.0385
Brugia malayi CHD4 protein 0.0015 0.0034 0.0149
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0051 0.0388 0.0388
Schistosoma mansoni chromobox protein 0.0014 0.0017 0.0017
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.095 0.3188
Schistosoma mansoni importin beta-1 0.0029 0.0168 0.0168
Schistosoma mansoni sphingosine kinase A B 0.0309 0.2981 0.2981
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0052 0.0404 0.0404
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0388 0.2315
Entamoeba histolytica hypothetical protein 0.0014 0.0017 0.0058
Brugia malayi CXXC zinc finger family protein 0.0029 0.0171 0.0749
Loa Loa (eye worm) hypothetical protein 0.0027 0.0146 0.049
Entamoeba histolytica hypothetical protein 0.0043 0.0315 0.1057
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0084 0.0367
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.095 0.3188
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0068 0.0914
Brugia malayi PHD-finger family protein 0.0013 0.0011 0.0049
Schistosoma mansoni peroxidasin 0.0027 0.0146 0.0146
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0068 1
Mycobacterium tuberculosis Conserved protein 0.0309 0.2981 1
Onchocerca volvulus 0.0041 0.029 0.1727
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0038
Plasmodium vivax importin-beta 2, putative 0.0029 0.0168 0.1003
Echinococcus granulosus dnaJ subfamily B 0.0414 0.403 0.403
Onchocerca volvulus Alhambra homolog 0.0035 0.0232 0.1386
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0081 0.0696 0.4152
Loa Loa (eye worm) hypothetical protein 0.0027 0.0146 0.049
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0081 0.0696 0.2336
Echinococcus granulosus Vam6:Vps39 protein 0.0051 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.005 0.0384 0.129
Toxoplasma gondii thioredoxin reductase 0.0047 0.0349 0.4708
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0349 0.2079
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.107 0.3589
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0185
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0162 0.1507 0.1507
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0349 0.0349
Onchocerca volvulus 0.0037 0.025 0.1491
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0798 0.0798
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.001 0.001
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0086 0.0741 0.0741
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0315 0.0315
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0042 0.0141
Schistosoma mansoni hypothetical protein 0.0019 0.007 0.007
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0114 0.1533
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0017 0.0234
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0146 0.0641
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0602
Loa Loa (eye worm) hypothetical protein 0.0051 0.0393 0.1319
Loa Loa (eye worm) VCP protein 0.0036 0.0235 0.079
Mycobacterium leprae conserved hypothetical protein 0.0041 0.029 0.1833
Echinococcus granulosus peregrin 0.0035 0.0232 0.0232
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0146 0.0641
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0068 0.0227
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0068 0.0914
Mycobacterium ulcerans ATPase 0.0051 0.0395 0.1324
Onchocerca volvulus Peroxidase homolog 0.0027 0.0146 0.087
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.029 0.0972
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0602
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0232 0.3138
Schistosoma mansoni cpg binding protein 0.0031 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0051 0.0388 0.1303
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0162 0.1507 0.662
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0014 0.0017 0.0234
Brugia malayi vesicle-fusing ATPase 0.005 0.0384 0.1689
Mycobacterium ulcerans beta-lactamase 0.0041 0.029 0.0972
Loa Loa (eye worm) hypothetical protein 0.0051 0.0388 0.1303
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0036 0.0235 0.0235
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.1009 1 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0083 0.1126
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.001 0.001
Schistosoma mansoni lipoxygenase 0.0686 0.6763 0.6763
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0055 0.0329
Trypanosoma cruzi Valosin-containing protein, putative 0.0081 0.0696 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0602
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0068 0.0972
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0292 0.1283
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0068 0.0403
Brugia malayi jmjC domain containing protein 0.0044 0.0323 0.142
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0388 0.5243
Leishmania major importin beta-1 subunit, putative 0.0023 0.0114 0.163
Schistosoma mansoni peroxidasin 0.0027 0.0146 0.0146
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0042 0.0566
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0055 0.0185
Schistosoma mansoni hypothetical protein 0.0035 0.0232 0.0232
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.029 0.0972
Brugia malayi hypothetical protein 0.0043 0.0315 0.1384
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0017 0.0234
Loa Loa (eye worm) hypothetical protein 0.0051 0.0388 0.1303
Echinococcus granulosus microtubule associated protein 2 0.0698 0.6882 0.6882
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.007 0.007
Brugia malayi valosin containing protein 0.005 0.0384 0.1689
Brugia malayi Valyl-tRNA synthetase 0.0014 0.0017 0.0076
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0483 0.2122
Loa Loa (eye worm) hypothetical protein 0.0035 0.0232 0.078
Schistosoma mansoni hypothetical protein 0.0169 0.1578 0.1578
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0017 0.0234
Loa Loa (eye worm) hypothetical protein 0.0023 0.0115 0.0385
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0042 0.0566
Plasmodium falciparum thioredoxin reductase 0.0016 0.0042 0.025
Brugia malayi RNA, U transporter 1 0.0082 0.0701 0.3079
Brugia malayi beta-lactamase 0.0041 0.029 0.1273
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0014 0.0017 0.0234
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.007 0.007
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0261 0.2502 0.8394
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0052 0.0404 0.0404
Echinococcus multilocularis cpg binding protein 0.0031 0.0187 0.0187
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0068 0.0403
Entamoeba histolytica hypothetical protein 0.0014 0.0017 0.0058
Echinococcus multilocularis protein patched 0.0042 0.0299 0.0299
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0146 0.087
Mycobacterium ulcerans hypothetical protein 0.0041 0.029 0.0972
Loa Loa (eye worm) hypothetical protein 0.0047 0.0352 0.1182
Echinococcus multilocularis snurportin 1 0.0307 0.2964 0.2964
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0352 0.4758
Brugia malayi Protein cec-1. 0.0014 0.0017 0.0076
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0723 0.9766
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0013 0.0012 0.0074
Giardia lamblia AAA family ATPase 0.0051 0.0395 1
Schistosoma mansoni hypothetical protein 0.004 0.0284 0.0284
Brugia malayi SET domain containing protein 0.0014 0.0024 0.0104
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0068 0.0227
Loa Loa (eye worm) hypothetical protein 0.0041 0.0292 0.098
Schistosoma mansoni hypothetical protein 0.0041 0.0292 0.0292
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0214 0.2892
Schistosoma mansoni lipoxygenase 0.1009 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0315 0.0315
Loa Loa (eye worm) hypothetical protein 0.0041 0.029 0.0972
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0014 0.0017 0.0234
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0214 0.2892
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0115 0.0385
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0723 0.9766
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0017 0.0234
Echinococcus granulosus sphingosine kinase 1 0.0309 0.2981 0.2981
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0027 0.0146 0.049
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0042 0.0141
Loa Loa (eye worm) hypothetical protein 0.0179 0.1678 0.5627
Mycobacterium tuberculosis Conserved protein 0.0041 0.029 0.0972
Echinococcus multilocularis chromobox protein 1 0.0084 0.0723 0.0723
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0055 0.0329
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0086 0.0741 0.0741
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0115 0.0385
Schistosoma mansoni sphingoid long chain base kinase 0.0309 0.2981 0.2981
Schistosoma mansoni rab6-interacting 0.0179 0.1678 0.1678
Onchocerca volvulus 0.0014 0.0017 0.0104
Echinococcus granulosus chromobox protein 2 0.0014 0.0017 0.0017
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0042 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0352 0.4758
Brugia malayi PHD-finger family protein 0.0035 0.0232 0.1021
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0058
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0146 0.0641
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0017 0.0234
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0042 0.0042
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0046 0.0153
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0349 0.117
Schistosoma mansoni chromobox protein 0.0014 0.0017 0.0017
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0115 0.0385
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0146 0.049
Mycobacterium ulcerans hypothetical protein 0.0023 0.0115 0.0385
Mycobacterium tuberculosis Probable reductase 0.0107 0.095 0.3188
Brugia malayi Temporarily assigned gene name protein 59 0.0051 0.0388 0.1706
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0046 0.0153
Plasmodium vivax glutathione reductase, putative 0.0047 0.0349 0.2079
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0115 0.0385
Loa Loa (eye worm) hypothetical protein 0.0027 0.0146 0.049
Loa Loa (eye worm) hypothetical protein 0.0041 0.029 0.0972
Loa Loa (eye worm) helicase 0.0014 0.0017 0.0058
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0058
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0146 0.049
Schistosoma mansoni hypothetical protein 0.0169 0.1578 0.1578
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.1036 0.1036
Loa Loa (eye worm) hypothetical protein 0.0029 0.0168 0.0564
Brugia malayi glutathione reductase 0.0047 0.0349 0.1532
Echinococcus multilocularis lipoxygenase domain containing protein 0.0179 0.1678 0.1678
Echinococcus granulosus cpg binding protein 0.0031 0.0187 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0299 0.4033
Brugia malayi hypothetical protein 0.0179 0.1678 0.7367
Entamoeba histolytica hypothetical protein 0.0023 0.0114 0.0381
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0055 1
Schistosoma mansoni hypothetical protein 0.0019 0.007 0.007
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0086 0.0741 0.0741
Brugia malayi map kinase activated protein kinase protein 2 0.0183 0.1718 0.7543
Brugia malayi beta-lactamase family protein 0.0041 0.029 0.1273
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0046 0.0153
Loa Loa (eye worm) hypothetical protein 0.0027 0.0146 0.049
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.029 0.3912
Brugia malayi Bromodomain containing protein 0.0035 0.0232 0.1021
Schistosoma mansoni hypothetical protein 0.004 0.0284 0.0284
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0042 0.0602
Echinococcus multilocularis GPCR, family 2 0.0019 0.007 0.007
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1326 0.4448
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.029 0.4161
Loa Loa (eye worm) hypothetical protein 0.0023 0.0115 0.0385
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0012 0.0074
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0042 0.0602
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0051 0.0388 0.0388
Giardia lamblia PHD finger protein 15 0.0035 0.0232 0.54
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.1277 0.1277
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0036 0.0235 0.1034
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0115 0.1646
Brugia malayi Blistered cuticle protein 3 0.0027 0.0146 0.0641
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0023 0.0115 0.0385
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0602
Schistosoma mansoni patched 1 0.0042 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0037 0.025 0.0839
Echinococcus multilocularis chromobox protein 1 0.0084 0.0723 0.0723
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0086 0.0741 0.4416
Brugia malayi MH2 domain containing protein 0.0144 0.1326 0.5823
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.029 0.3912
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0014 0.0017 0.0017
Echinococcus granulosus expressed conserved protein 0.0092 0.0798 0.0798
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0183 0.1718 0.1718
Loa Loa (eye worm) doublecortin family protein 0.0179 0.1678 0.5627
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.1277 0.1277
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0307 0.0307
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0388 0.5243
Echinococcus granulosus snurportin 1 0.0307 0.2964 0.2964
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0114 0.1533
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0051 0.0395 0.533
Loa Loa (eye worm) hypothetical protein 0.0027 0.0146 0.049
Mycobacterium tuberculosis Conserved protein 0.0041 0.029 0.0972
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0058
Echinococcus multilocularis sphingosine kinase 1 0.0309 0.2981 0.2981
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0058
Toxoplasma gondii exonuclease III APE 0.0019 0.0068 0.0914
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0052 0.0404 0.0404
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0602
Plasmodium falciparum importin beta, putative 0.0029 0.0168 0.1003
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0051 0.0388 0.5578
Schistosoma mansoni chromobox protein 0.0084 0.0723 0.0723
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0051 0.0388 0.0388
Onchocerca volvulus 0.0014 0.0024 0.0141
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.029 0.0972
Schistosoma mansoni chromobox protein 0.0084 0.0723 0.0723
Mycobacterium tuberculosis Conserved protein 0.0041 0.029 0.0972
Schistosoma mansoni rab6-interacting 0.0179 0.1678 0.1678
Loa Loa (eye worm) vesicle-fusing ATPase 0.005 0.0384 0.129
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0017 0.0234
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0017 0.0234
Onchocerca volvulus 0.0014 0.0017 0.0104
Loa Loa (eye worm) hypothetical protein 0.006 0.0483 0.1621
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0115 0.0385
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0146 0.049
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0857 0.2875
Echinococcus multilocularis Polycystic kidney disease protein 0.0179 0.1678 0.1678
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0115 0.1646
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.029 0.1273
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0068 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0053 0.0713
Trypanosoma brucei trypanothione reductase 0.0047 0.0349 0.5008
Entamoeba histolytica hypothetical protein, conserved 0.0309 0.2981 1
Schistosoma mansoni cpg binding protein 0.0031 0.0187 0.0187
Entamoeba histolytica hypothetical protein 0.0043 0.0315 0.1057
Toxoplasma gondii ABC1 family protein 0.0041 0.029 0.3912
Onchocerca volvulus 0.0027 0.0146 0.087
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0086 0.0741 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.1036 0.1036
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.107 0.3589
Brugia malayi probable protein kinase 0.0173 0.1617 0.7101
Echinococcus granulosus protein kinase 0.0122 0.1108 0.1108
Echinococcus multilocularis microtubule associated protein 2 0.0698 0.6882 0.6882
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0115 0.0503
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0232 0.1386
Onchocerca volvulus 0.0023 0.0115 0.0683
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0371 0.0371
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0232 0.0232
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0042 0.0566
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0162 0.1507 0.8986
Schistosoma mansoni cpg binding protein 0.0029 0.0171 0.0171
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0115 0.0385
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0017 0.0104
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0051 0.0388 0.5578
Brugia malayi CHE-14 protein 0.0042 0.0299 0.1312
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0081 0.0696 0.4152
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.029 0.3912
Onchocerca volvulus 0.0041 0.029 0.1727
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0042 0.0602
Plasmodium vivax hypothetical protein, conserved 0.0041 0.029 0.1727
Brugia malayi hypothetical protein 0.0014 0.0017 0.0076
Echinococcus granulosus geminin 0.0169 0.1578 0.1578
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0068 0.0972
Loa Loa (eye worm) hypothetical protein 0.0041 0.029 0.0972
Plasmodium falciparum glutathione reductase 0.0016 0.0042 0.025
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0017 0.0058
Echinococcus multilocularis 0.0122 0.1108 0.1108
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0857 0.0857
Onchocerca volvulus Peroxidase homolog 0.0027 0.0146 0.087
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0042 0.0184
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0083 0.1126
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.029 0.0972
Onchocerca volvulus 0.0029 0.0171 0.1017
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0017 0.0017
Onchocerca volvulus 0.0027 0.0146 0.087
Echinococcus granulosus Polycystic kidney disease protein 0.0179 0.1678 0.1678
Schistosoma mansoni polycystin 1-related 0.0179 0.1678 0.1678
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0017 0.0234
Plasmodium falciparum LCCL domain-containing protein 0.0179 0.1678 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0431 0.5822
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0042 0.0042
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.007 0.007
Schistosoma mansoni serine/threonine protein kinase 0.0183 0.1718 0.1718
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0017 0.0058
Mycobacterium leprae Probable lipase LipE 0.0041 0.029 0.1833
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.029 0.029
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0014 0.0017 0.0017
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0352 0.2101
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0115 0.1646
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0046 0.0153
Plasmodium vivax heterochromatin protein 1, putative 0.0014 0.0017 0.0104
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0027 0.0146 0.049
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0115 0.0503
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0299 0.1002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0058
Loa Loa (eye worm) hypothetical protein 0.0309 0.2981 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0042 0.0042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0048 0.0648
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0053 0.0713
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.029 0.0972
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0017 0.0234
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0083 0.1126
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0168 0.2415
Loa Loa (eye worm) hypothetical protein 0.0027 0.0146 0.049
Brugia malayi Peroxidasin 0.0027 0.0146 0.0641
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0083 0.1126
Echinococcus multilocularis Chromo domain 0.0014 0.0017 0.0017
Brugia malayi hypothetical protein 0.0051 0.0388 0.1706
Echinococcus multilocularis peregrin 0.0035 0.0232 0.0232
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0042 0.0602
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.403 0.403
Loa Loa (eye worm) hypothetical protein 0.0027 0.0146 0.049
Plasmodium falciparum thioredoxin reductase 0.0047 0.0349 0.2079
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0299 0.0299
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0083 0.1126
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0232 0.0232
Schistosoma mansoni hypothetical protein 0.0014 0.0017 0.0017
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0068 0.0227
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0042 0.025
Loa Loa (eye worm) hypothetical protein 0.0027 0.0146 0.049
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0299 0.0299
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0404 0.0404
Mycobacterium ulcerans hypothetical protein 0.0309 0.2981 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0162 0.1507 0.5057
Echinococcus multilocularis expressed conserved protein 0.0092 0.0798 0.0798
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0068 0.0068
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0042 0.0566
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0114 0.1533
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0146 0.087
Trichomonas vaginalis esterase, putative 0.0041 0.029 0.3912
Onchocerca volvulus 0.0179 0.1678 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0042 0.0602
Echinococcus granulosus GPCR family 2 0.0019 0.007 0.007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0483 0.1621

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 95.2834 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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