Detailed information for compound 1525070

Basic information

Technical information
  • TDR Targets ID: 1525070
  • Name: 5-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyri din-3-yl)-5-methyl-3,5-dihydroimidazol-2-yl]- 1-methylpyridin-2-one
  • MW: 380.391 | Formula: C21H18F2N4O
  • H donors: 1 H acceptors: 2 LogP: 2.14 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)[C@]1(N=C(N[C@H]1C)c1ccc(=O)n(c1)C)c1ccc(nc1)F
  • InChi: 1S/C21H18F2N4O/c1-13-21(15-4-7-17(22)8-5-15,16-6-9-18(23)24-11-16)26-20(25-13)14-3-10-19(28)27(2)12-14/h3-13H,1-2H3,(H,25,26)/t13-,21-/m0/s1
  • InChiKey: BDYBUJFDECYUHB-ZSEKCTLFSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoro-3-pyridyl)-5-methyl-3,5-dihydroimidazol-2-yl]-1-methyl-pyridin-2-one
  • 5-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoro-3-pyridyl)-5-methyl-3,5-dihydroimidazol-2-yl]-1-methyl-2-pyridinone
  • 5-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoro-3-pyridyl)-5-methyl-3,5-dihydroimidazol-2-yl]-1-methyl-2-pyridone
  • 5-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyridin-3-yl)-5-methyl-3,5-dihydroimidazol-2-yl]-1-methyl-pyridin-2-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide Y receptor Y5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0347 0.1485 1
Entamoeba histolytica type A flavoprotein, putative 0.0066 0.0265 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0025 0.017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0025 0.017
Trichomonas vaginalis beta lactamase domain, putative 0.0066 0.0265 0.174
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0011 0.0075
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0003 0.0018
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0066 0.0265 0.1785
Brugia malayi beta-lactamase family protein 0.0347 0.1485 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0025 0.017
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.1106 0.4788 1
Chlamydia trachomatis transglycolase/transpeptidase 0.0155 0.0652 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.2214 0.9609 0.9606
Schistosoma mansoni coup transcription factor 0.0011 0.0025 0.017
Loa Loa (eye worm) hypothetical protein 0.0347 0.1485 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.017
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0066 0.0447
Loa Loa (eye worm) hypothetical protein 0.0347 0.1485 1
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0066 0.0265 0.1401
Onchocerca volvulus 0.0347 0.1485 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0347 0.1485 1
Mycobacterium ulcerans hypothetical protein 0.0347 0.1485 0.1428
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.1106 0.4788 0.4753
Trichomonas vaginalis beta lactamase domain, putative 0.0066 0.0265 0.174
Mycobacterium ulcerans lipoprotein LpqF 0.1106 0.4788 0.4753
Mycobacterium tuberculosis Probable esterase LipL 0.0347 0.1485 0.1428
Echinococcus multilocularis beta LACTamase domain containing family member 0.0347 0.1485 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0025 0.017
Loa Loa (eye worm) beta-lactamase 0.0347 0.1485 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0025 0.017
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0025 0.017
Brugia malayi ethe1-prov protein 0.0066 0.0265 0.1785
Trypanosoma cruzi glyoxalase II 0.0066 0.0265 0.1401
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0265 0.174
Loa Loa (eye worm) hypothetical protein 0.0089 0.0364 0.2449
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0025 0.017
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0025 0.017
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0025 0.017
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0003 0.0018
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0025 0.017
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0011 0.0075
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0066 0.0265 0.1785
Mycobacterium ulcerans hydrolase 0.0066 0.0265 0.02
Leishmania major hypothetical protein, conserved 0.0066 0.0265 0.1401
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0025 0.017
Echinococcus granulosus cpg binding protein 0.0033 0.0121 0.0815
Entamoeba histolytica hypothetical protein 0.0039 0.0148 0.4085
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0025 0.017
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0025 0.017
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0066 0.0265 0.1785
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0155 0.0652 0.059
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.0155 0.0652 0.0856
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.0155 0.0652 0.059
Trypanosoma brucei beta lactamase 0.1106 0.4788 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0025 0.017
Loa Loa (eye worm) histone methyltransferase 0.001 0.0019 0.0131
Onchocerca volvulus 0.0066 0.0265 0.1785
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0025 0.017
Treponema pallidum penicillin-binding protein (pbp-2) 0.0155 0.0652 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0025 0.017
Trypanosoma brucei hypothetical protein, conserved 0.0347 0.1485 0.3004
Loa Loa (eye worm) hypothetical protein 0.0066 0.0265 0.1785
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0066 0.0394
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0347 0.1485 1
Mycobacterium ulcerans penicillin-binding protein PbpA 0.0155 0.0652 0.059
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0003 0.0018
Mycobacterium tuberculosis Probable lipase LipD 0.0347 0.1485 0.1428
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0155 0.0652 0.059
Loa Loa (eye worm) hypothetical protein 0.0347 0.1485 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0025 0.017
Trypanosoma cruzi glyoxalase II 0.0066 0.0265 0.1401
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0025 0.017
Leishmania major hypothetical protein, conserved 0.0347 0.1485 1
Schistosoma mansoni zinc phosphodiesterase 0.0066 0.0265 0.1785
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0066 0.0265 0.1785
Entamoeba histolytica alkyl sulfatase, putative 0.0066 0.0265 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0025 0.017
Toxoplasma gondii ABC1 family protein 0.0347 0.1485 1
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0066 0.0265 0.1401
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0025 0.017
Entamoeba histolytica metallo-beta-lactamase family protein 0.0066 0.0265 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.017
Brugia malayi beta-lactamase family protein 0.0347 0.1485 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0025 0.017
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0025 0.017
Trichomonas vaginalis beta lactamase domain, putative 0.0066 0.0265 0.174
Mycobacterium ulcerans beta-lactamase 0.0347 0.1485 0.1428
Brugia malayi nuclear receptor NHR-88 0.0011 0.0025 0.017
Entamoeba histolytica hypothetical protein 0.0039 0.0148 0.4085
Trypanosoma cruzi glyoxalase II 0.0066 0.0265 0.1401
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0265 0.174
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.0155 0.0652 1
Mycobacterium tuberculosis Conserved protein 0.0066 0.0265 0.02
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0066 0.0265 0.1785
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0025 0.017
Entamoeba histolytica metallo-beta-lactamase family protein 0.0066 0.0265 1
Mycobacterium tuberculosis Conserved protein 0.0347 0.1485 0.1428
Schistosoma mansoni hypothetical protein 0.0066 0.0265 0.1785
Entamoeba histolytica hypothetical protein, conserved 0.0066 0.0265 1
Schistosoma mansoni jun-related protein 0.0074 0.03 0.2021
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0018
Echinococcus granulosus zinc phosphodiesterase 0.0066 0.0265 0.1785
Mycobacterium tuberculosis Probable hydrolase 0.0347 0.1485 0.1428
Brugia malayi steroid hormone receptor 0.0011 0.0025 0.017
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0019 0.0131
Trichomonas vaginalis A-type flavoprotein 0.0066 0.0265 0.174
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0025 0.017
Loa Loa (eye worm) hypothetical protein 0.0066 0.0265 0.1785
Mycobacterium leprae conserved hypothetical protein 0.0347 0.1485 0.2697
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0025 0.017
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0025 0.017
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0155 0.0652 0.059
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0347 0.1485 0.1428
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0347 0.1485 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0066 0.0447
Schistosoma mansoni cpg binding protein 0.0033 0.0121 0.0815
Brugia malayi beta-lactamase 0.0347 0.1485 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0025 0.017
Mycobacterium tuberculosis Conserved protein 0.0066 0.0265 0.02
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0347 0.1485 0.1428
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0025 0.017
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0025 0.017
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0066 0.0265 1
Trichomonas vaginalis apoptosis inducing factor, putative 0.0066 0.0265 0.174
Loa Loa (eye worm) hypothetical protein 0.0066 0.0265 0.1785
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0066 0.0265 0.1401
Trichomonas vaginalis esterase, putative 0.0347 0.1485 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0091 0.0374 0.2522
Schistosoma mansoni ap endonuclease 0.002 0.0066 0.0447
Treponema pallidum ribonuclease Z 0.0066 0.0265 0.3391
Mycobacterium tuberculosis Conserved protein 0.0347 0.1485 0.1428
Schistosoma mansoni hypothetical protein 0.0039 0.0148 0.0994
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0066 0.0265 0.02
Entamoeba histolytica alkyl sulfatase, putative 0.0066 0.0265 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0018
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0003 0.0018
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0091 0.0374 0.2522
Schistosoma mansoni hypothetical protein 0.0066 0.0265 0.1785
Schistosoma mansoni cpg binding protein 0.0031 0.0113 0.0763
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0066 0.0265 0.1785
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0066 0.0265 0.1785
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0025 0.017
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0066 0.0265 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0025 0.017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0265 0.1788
Schistosoma mansoni hypothetical protein 0.0074 0.03 0.2021
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0003 0.0018
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0066 0.0447
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0066 0.0265 0.1785
Mycobacterium ulcerans hypothetical protein 0.0066 0.0265 0.02
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0019 0.0127
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.017
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0025 0.017
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.017
Brugia malayi nuclear receptor RXR 0.0006 0.0003 0.0018
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0066 0.0447
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0066 0.0265 0.3391
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0011 0.0075
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0066 0.0265 0.1401
Echinococcus multilocularis ETHE1 protein 0.0066 0.0265 0.1785
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0066 0.0265 0.1785
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0066 0.0265 0.1401
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0155 0.0652 0.0856
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0025 0.017
Trichomonas vaginalis beta lactamase domain, putative 0.0066 0.0265 0.174
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0155 0.0652 0.0856
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0066 0.0265 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0066 0.0265 0.02
Mycobacterium ulcerans esterase/lipase LipP 0.0347 0.1485 0.1428
Onchocerca volvulus 0.0011 0.0025 0.017
Echinococcus multilocularis cpg binding protein 0.0033 0.0121 0.0815
Onchocerca volvulus Putative hydrolase PNKD 0.0066 0.0265 0.1785
Loa Loa (eye worm) hypothetical protein 0.0347 0.1485 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0347 0.1485 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0025 0.017
Trichomonas vaginalis beta lactamase domain, putative 0.0066 0.0265 0.174
Mycobacterium tuberculosis Conserved protein 0.0347 0.1485 0.1428
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0148 0.0994
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0066 0.0394
Plasmodium vivax unspecified product 0.0066 0.0265 0.1401
Entamoeba histolytica hypothetical protein 0.0039 0.0148 0.4085
Trichomonas vaginalis D-aminoacylase, putative 0.0347 0.1485 1
Brugia malayi hypothetical protein 0.0066 0.0265 0.1785
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0066 0.0265 0.1785
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0025 0.017
Onchocerca volvulus 0.0347 0.1485 1
Entamoeba histolytica metallo-beta-lactamase family protein 0.0066 0.0265 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0025 0.017
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0155 0.0652 0.0856
Schistosoma mansoni ap endonuclease 0.002 0.0066 0.0447
Mycobacterium tuberculosis Possible hydrolase 0.0066 0.0265 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0265 0.174
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0025 0.017
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0025 0.017
Mycobacterium tuberculosis Possible hydrolase 0.0066 0.0265 0.02
Leishmania major metallo-beta-lactamase family protein-like protein 0.0066 0.0265 0.1401
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.2304 1 1
Schistosoma mansoni hypothetical protein 0.0066 0.0265 0.1785
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0025 0.017
Trichomonas vaginalis D-aminoacylase, putative 0.0347 0.1485 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0025 0.017
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0025 0.017
Brugia malayi nuclear hormone receptor 0.0011 0.0025 0.017
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0025 0.017
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0347 0.1485 1
Trichomonas vaginalis D-aminoacylase, putative 0.0347 0.1485 1
Treponema pallidum penicillin-binding protein (pbp-3) 0.0155 0.0652 1
Trypanosoma cruzi hypothetical protein, conserved 0.0347 0.1485 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0011 0.0075
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0148 0.0994
Echinococcus multilocularis jun protein 0.0091 0.0374 0.2522
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0003 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0025 0.017
Mycobacterium ulcerans hydrolase 0.0066 0.0265 0.02
Onchocerca volvulus 0.0072 0.0289 0.1948
Mycobacterium tuberculosis Conserved hypothetical protein 0.0066 0.0265 0.02
Mycobacterium ulcerans beta lactamase-like protein 0.0066 0.0265 0.02
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0025 0.017
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0066 0.0265 0.1401
Echinococcus multilocularis zinc phosphodiesterase 0.0066 0.0265 0.1785
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0025 0.017
Echinococcus granulosus jun protein 0.0091 0.0374 0.2522
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0155 0.0652 0.059
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0025 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0265 0.174
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0025 0.017
Schistosoma mansoni cpg binding protein 0.0033 0.0121 0.0815
Mycobacterium tuberculosis Probable lipase LipE 0.0347 0.1485 0.1428
Mycobacterium ulcerans hypothetical protein 0.0066 0.0265 0.02
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0066 0.0265 0.1401
Loa Loa (eye worm) hypothetical protein 0.0347 0.1485 1
Onchocerca volvulus 0.0031 0.0113 0.0763
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0018
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0066 0.0265 0.174
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.0652 0.4363
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0155 0.0652 0.059
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0025 0.017
Mycobacterium tuberculosis Conserved protein 0.0066 0.0265 0.02
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0066 0.0265 0.1785
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0265 0.174
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0025 0.017
Brugia malayi bZIP transcription factor family protein 0.0091 0.0374 0.2522
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0025 0.017
Leishmania major metallo-beta-lactamase family-like protein 0.0066 0.0265 0.1401
Plasmodium falciparum cytosolic glyoxalase II 0.0066 0.0265 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.017
Brugia malayi metallo-beta-lactamase superfamily protein 0.0066 0.0265 0.1785
Brugia malayi hypothetical protein 0.0039 0.0148 0.0994
Treponema pallidum penicillin-binding protein (pbp-1) 0.0155 0.0652 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0265 0.1785
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0025 0.017
Brugia malayi hypothetical protein 0.0072 0.0289 0.1948
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0025 0.017
Schistosoma mansoni zinc phosphodiesterase 0.0066 0.0265 0.1785
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0113 0.0763
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0148 0.0994
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0347 0.1485 0.1428
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0265 0.174
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0066 0.0265 1
Brugia malayi ecdysteroid receptor 0.0011 0.0025 0.017
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0066 0.0265 0.1401
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0066 0.0265 0.0421
Brugia malayi hypothetical protein 0.0006 0.0003 0.0018
Onchocerca volvulus 0.0066 0.0265 0.1785
Plasmodium vivax hypothetical protein, conserved 0.0347 0.1485 1
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0066 0.0265 0.0421
Onchocerca volvulus 0.0347 0.1485 1
Mycobacterium tuberculosis Beta lactamase like protein 0.0066 0.0265 0.02
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0025 0.017
Mycobacterium ulcerans hypothetical protein 0.0066 0.0265 0.02
Mycobacterium ulcerans glyoxalase II, GloB 0.0066 0.0265 0.02
Trypanosoma cruzi hypothetical protein, conserved 0.0347 0.1485 1
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0066 0.0265 0.1785
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0011 0.0075
Brugia malayi metallo-beta-lactamase superfamily protein 0.0066 0.0265 0.1785
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0066 0.0265 0.1401
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0066 0.0265 0.0421
Mycobacterium ulcerans hydrolase 0.0066 0.0265 0.02
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0066 0.0265 0.1401
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0025 0.017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0025 0.017
Mycobacterium ulcerans lipase LipD 0.0347 0.1485 0.1428
Trichomonas vaginalis beta lactamase domain, putative 0.0066 0.0265 0.174
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0025 0.017
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.0155 0.0652 0.059
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0019 0.0131
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0018
Brugia malayi CXXC zinc finger family protein 0.0031 0.0113 0.0763
Trypanosoma brucei glyoxalase II 0.0066 0.0265 0.0421
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0066 0.0265 0.1401
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0235 0.1187
Mycobacterium ulcerans hypothetical protein 0.0066 0.0265 0.02
Brugia malayi hypothetical protein 0.0006 0.0003 0.0018
Echinococcus granulosus beta LACTamase domain containing family member 0.0347 0.1485 1
Entamoeba histolytica hypothetical protein 0.0039 0.0148 0.4085
Echinococcus granulosus ETHE1 protein 0.0066 0.0265 0.1785
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0025 0.017
Chlamydia trachomatis transglycolase/transpeptidase 0.0155 0.0652 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0066 0.0265 0.02
Mycobacterium leprae Probable lipase LipE 0.0347 0.1485 0.2697
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0003 0.0018
Entamoeba histolytica type A flavoprotein, putative 0.0066 0.0265 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0347 0.1485 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0347 0.1485 0.1428
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0018
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0066 0.0265 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 13 nM Displacement of [125I]PPY from human recombinant NPYY5 receptor expressed in mouse LMtk- cells ChEMBL. 19616955

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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