Detailed information for compound 1525125

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 465.536 | Formula: C26H24FNO4S
  • H donors: 1 H acceptors: 4 LogP: 5.06 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)[C@@H]1CC=C([C@@H](N1S(=O)(=O)c1ccccc1C)c1cccc(c1)F)C(=O)O
  • InChi: 1S/C26H24FNO4S/c1-17-10-12-19(13-11-17)23-15-14-22(26(29)30)25(20-7-5-8-21(27)16-20)28(23)33(31,32)24-9-4-3-6-18(24)2/h3-14,16,23,25H,15H2,1-2H3,(H,29,30)/t23-,25-/m0/s1
  • InChiKey: AIMOJIXCJYIJTG-ZCYQVOJMSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Brugia malayi PAN domain containing protein 0.0158 0.0277 0.047
Loa Loa (eye worm) hypothetical protein 0.0076 0.0045 0.0077
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0168 0.0304 0.0304
Echinococcus multilocularis serotonin receptor 0.0168 0.0304 0.0304
Leishmania major beta tubulin 0.0066 0.0017 0.0064
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0168 0.0304 0.0304
Schistosoma mansoni nAChR subunit 0.0141 0.0228 0.0244
Echinococcus multilocularis g-protein coupled receptor 0.0168 0.0304 0.0304
Echinococcus multilocularis neuropeptide Y receptor 0.0168 0.0304 0.0304
Brugia malayi PAN domain containing protein 0.0158 0.0277 0.047
Brugia malayi GnHR receptor homolog 0.0168 0.0304 0.0517
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0168 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0081 0.0059 0.01
Echinococcus granulosus neuropeptide FF receptor 2 0.0168 0.0304 0.0304
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0168 0.0304 0.033
Leishmania major beta tubulin 0.0066 0.0017 0.0064
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0141 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0362 0.0851 0.1446
Onchocerca volvulus 0.0158 0.0277 0.2496
Trypanosoma brucei calpain-like protein, putative 0.0111 0.0144 0.1515
Onchocerca volvulus 0.0168 0.0304 0.2743
Schistosoma mansoni serine-type protease inhibitor 0.3179 0.8793 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0081 0.006 1
Onchocerca volvulus 0.0168 0.0304 0.2743
Schistosoma mansoni biogenic amine receptor 0.0168 0.0304 0.033
Loa Loa (eye worm) apoptosis regulator protein 0.0362 0.0851 0.1446
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0168 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0141 0.0228 0.0388
Echinococcus granulosus neuropeptide receptor 0.0168 0.0304 0.0304
Echinococcus granulosus rhodopsin orphan GPCR 0.0168 0.0304 0.0304
Brugia malayi Deoxyribonuclease II family protein 0.0071 0.003 0.0052
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.028 0.0621 0.1055
Brugia malayi phosphoinositide-dependent protein kinase I 0.0108 0.0137 0.0232
Brugia malayi hypothetical protein 0.0065 0.0014 0.0024
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0144 0.1619
Onchocerca volvulus 0.0168 0.0304 0.2743
Loa Loa (eye worm) hypothetical protein 0.0186 0.0355 0.0604
Brugia malayi hypothetical protein 0.0065 0.0014 0.0024
Toxoplasma gondii heat shock protein HSP90 0.0069 0.0025 0.0012
Leishmania major beta tubulin 0.0066 0.0017 0.0064
Loa Loa (eye worm) PAN domain-containing protein 0.0158 0.0277 0.047
Echinococcus multilocularis heat shock protein 0.0069 0.0025 0.0025
Schistosoma mansoni tubulin subunit beta 0.0066 0.0017 0.0003
Schistosoma mansoni neurotransmitter gated ion channel 0.0076 0.0045 0.0035
Toxoplasma gondii microneme protein MIC17B 0.0158 0.0277 0.0385
Toxoplasma gondii transporter, cation channel family protein 0.0169 0.0308 0.0431
Schistosoma mansoni nAChR subunit 0.0141 0.0228 0.0244
Schistosoma mansoni neuropeptide receptor 0.0168 0.0304 0.033
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0065 0.0014 0.0024
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0168 0.0304 0.033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0081 0.0059 0.01
Onchocerca volvulus 0.0168 0.0304 0.2743
Loa Loa (eye worm) hypothetical protein 0.0141 0.0228 0.0388
Schistosoma mansoni tubulin subunit beta 0.0066 0.0017 0.0003
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Schistosoma mansoni tubulin subunit beta 0.0066 0.0017 0.0003
Schistosoma mansoni hypothetical protein 0.0121 0.0171 0.0179
Echinococcus multilocularis adenylate cyclase type IX 0.0084 0.0068 0.0068
Loa Loa (eye worm) PAN domain-containing protein 0.0158 0.0277 0.047
Loa Loa (eye worm) hypothetical protein 0.0065 0.0014 0.0024
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0168 0.0304 0.0517
Schistosoma mansoni amine GPCR 0.0168 0.0304 0.033
Leishmania major heat shock protein 83-1 0.0069 0.0025 0.0113
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0062 0.0007 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.1 0.2651 0.4503
Schistosoma mansoni opsin-like receptor 0.0168 0.0304 0.033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0081 0.0059 0.01
Schistosoma mansoni integrin alpha 0.0152 0.0259 0.0278
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0255 0.055 0.0935
Brugia malayi PAN domain containing protein 0.0158 0.0277 0.047
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Loa Loa (eye worm) tubulin beta-2A chain 0.0066 0.0017 0.0029
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0111 0.0144 0.1515
Echinococcus granulosus tm gpcr rhodopsin 0.1697 0.4614 0.4614
Brugia malayi nuclear receptor NHR-88 0.0081 0.0059 0.01
Echinococcus granulosus Tubulin beta 2C chain 0.0066 0.0017 0.0017
Brugia malayi hypothetical protein 0.0168 0.0304 0.0517
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0111 0.0144 0.1619
Echinococcus multilocularis integrin alpha ps 0.0068 0.0023 0.0023
Echinococcus multilocularis glycine receptor subunit beta 0.0141 0.0228 0.0228
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0075 0.0041 0.1569
Brugia malayi hypothetical protein 0.0065 0.0014 0.0024
Echinococcus granulosus neuropeptides capa receptor 0.0168 0.0304 0.0304
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0169 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Schistosoma mansoni hypothetical protein 0.0075 0.0041 0.0031
Schistosoma mansoni biogenic amine receptor 0.0168 0.0304 0.033
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0169 0.0308 0.0308
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0065 0.0014 0.0024
Onchocerca volvulus 0.0168 0.0304 0.2743
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0168 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0141 0.0228 0.0388
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0168 0.0304 0.0517
Brugia malayi PAN domain containing protein 0.0158 0.0277 0.047
Brugia malayi ecdysteroid receptor 0.0081 0.0059 0.01
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0099 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0115 0.0155 0.0263
Echinococcus granulosus rhodopsin orphan GPCR 0.0168 0.0304 0.0304
Echinococcus granulosus tubulin beta 1 chain 0.0066 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.1 0.2651 0.4503
Onchocerca volvulus 0.0141 0.0228 0.2061
Brugia malayi Endoplasmin precursor 0.0069 0.0025 0.0043
Echinococcus granulosus g protein coupled receptor 0.0168 0.0304 0.0304
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0303 0.545
Plasmodium falciparum cysteine repeat modular protein 1 0.0075 0.0041 0.1569
Brugia malayi AKH receptor 0.0168 0.0304 0.0517
Brugia malayi hypothetical protein 0.0168 0.0304 0.0517
Echinococcus granulosus somatostatin receptor 0.0168 0.0304 0.0304
Schistosoma mansoni hypothetical protein 0.0168 0.0304 0.033
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0141 0.0228 0.0228
Brugia malayi sulfakinin receptor protein 0.1216 0.326 0.5537
Toxoplasma gondii hypothetical protein 0.0113 0.015 0.0198
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.055 1
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0141 0.0228 0.0244
Leishmania major heat shock protein 83-1 0.0069 0.0025 0.0113
Echinococcus granulosus ecdysone induced protein 78C 0.0081 0.0059 0.0059
Brugia malayi ORL1-like opioid receptor 0.0168 0.0304 0.0517
Echinococcus granulosus g protein coupled receptor 0.0168 0.0304 0.0304
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0081 0.0059 0.0059
Echinococcus multilocularis nAChR subunit 0.0141 0.0228 0.0228
Loa Loa (eye worm) GABA receptor subunit 0.0076 0.0045 0.0077
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0144 0.0847
Brugia malayi Dopamine receptor protein 1 0.0168 0.0304 0.0517
Onchocerca volvulus 0.0065 0.0014 0.0129
Onchocerca volvulus 0.0121 0.0171 0.1546
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0081 0.0059 0.01
Schistosoma mansoni tubulin subunit beta 0.0066 0.0017 0.0003
Trypanosoma brucei RNA helicase, putative 0.0209 0.042 0.4804
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0081 0.0059 0.01
Schistosoma mansoni coup transcription factor 0.0081 0.0059 0.0051
Onchocerca volvulus 0.0158 0.0277 0.2496
Trypanosoma brucei hypothetical protein 0.0111 0.0144 0.1515
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Brugia malayi photoreceptor-specific nuclear receptor 0.0081 0.0059 0.01
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0168 0.0304 0.0304
Trypanosoma brucei heat shock protein, putative 0.0069 0.0025 0.0094
Trypanosoma brucei heat shock protein, putative 0.0069 0.0025 0.0094
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0364 0.0857 0.1455
Loa Loa (eye worm) hypothetical protein 0.0076 0.0045 0.0077
Schistosoma mansoni endoplasmin 0.0069 0.0025 0.0012
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0113 0.0149 0.0149
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.028 0.0621 0.0621
Loa Loa (eye worm) neuropeptide F receptor 0.0168 0.0304 0.0517
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0065 0.0014 0.0014
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0141 0.0228 0.0388
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0168 0.0304 0.0517
Brugia malayi Cation transporter family protein 0.0453 0.1109 0.1883
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0329 0.5918
Loa Loa (eye worm) hypothetical protein 0.0065 0.0014 0.0024
Loa Loa (eye worm) integrin alpha pat-2 0.0234 0.049 0.0833
Loa Loa (eye worm) hypothetical protein 0.0158 0.0277 0.047
Trichomonas vaginalis deoxyribonuclease II, putative 0.0071 0.003 0.0433
Echinococcus multilocularis Tubulin beta 2C chain 0.0066 0.0017 0.0017
Loa Loa (eye worm) melatonin receptor type 1A 0.0168 0.0304 0.0517
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0304 0.0304
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0169 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0081 0.0059 0.01
Trypanosoma cruzi heat shock protein 85, putative 0.0069 0.0025 0.0215
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0081 0.0059 0.0059
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0141 0.0228 0.0228
Loa Loa (eye worm) voltage-dependent calcium channel 0.0169 0.0308 0.0523
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Echinococcus multilocularis dro:myosuppressin receptor 0.0168 0.0304 0.0304
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0304 0.033
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0168 0.0304 0.0517
Schistosoma mansoni protein kinase 0.0142 0.0231 0.0247
Echinococcus multilocularis Tubulin beta 2C chain 0.0066 0.0017 0.0017
Brugia malayi Kringle domain containing protein 0.0075 0.0041 0.007
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0453 0.1109 0.1247
Brugia malayi Caveolin-1 0.0523 0.1306 0.2219
Onchocerca volvulus 0.0158 0.0277 0.2496
Trypanosoma cruzi heat shock protein 90, putative 0.0069 0.0025 0.0215
Brugia malayi Steroid receptor seven-up type 2 0.0081 0.0059 0.01
Leishmania major beta tubulin 0.0066 0.0017 0.0064
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0304 0.033
Loa Loa (eye worm) hypothetical protein 0.0065 0.0014 0.0024
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0081 0.0059 0.0059
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0142 0.0231 0.0231
Echinococcus granulosus beta tubulin 0.0066 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0081 0.0059 0.01
Onchocerca volvulus Bile acid receptor homolog 0.0081 0.0059 0.0531
Loa Loa (eye worm) G-protein coupled receptor 0.0168 0.0304 0.0517
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0076 0.0045 0.0077
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0121 0.0171 0.0171
Brugia malayi larval opioid receptor 0.0168 0.0304 0.0517
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.055 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0059 0.01
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.2148 0.5887 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0168 0.0304 0.033
Schistosoma mansoni hypothetical protein 0.0362 0.0851 0.0953
Loa Loa (eye worm) hypothetical protein 0.0158 0.0277 0.047
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0081 0.0059 0.0531
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0081 0.0059 0.01
Schistosoma mansoni hypothetical protein 0.0168 0.0304 0.033
Echinococcus granulosus orexin receptor type 2 0.0168 0.0304 0.0304
Toxoplasma gondii heat shock protein 90, putative 0.0069 0.0025 0.0012
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0076 0.0045 0.0035
Brugia malayi PAN domain containing protein 0.0158 0.0277 0.047
Leishmania major heat shock protein 83-1 0.0069 0.0025 0.0113
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0121 0.0171 0.0171
Schistosoma mansoni steroid hormone receptor ad4bp 0.0081 0.0059 0.0051
Toxoplasma gondii PAN domain-containing protein 0.0158 0.0277 0.0385
Trichomonas vaginalis tubulin epsilon chain, putative 0.0066 0.0017 0.0191
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0141 0.0228 0.0388
Onchocerca volvulus 0.0141 0.0228 0.2061
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0168 0.0304 0.0517
Trypanosoma cruzi heat shock protein 85, putative 0.0069 0.0025 0.0215
Leishmania major beta tubulin 0.0066 0.0017 0.0064
Schistosoma mansoni neuropeptide f receptor 76f 0.0168 0.0304 0.033
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0081 0.0059 0.01
Toxoplasma gondii PAN/Apple domain-containing protein 0.0158 0.0277 0.0385
Loa Loa (eye worm) hypothetical protein 0.0158 0.0277 0.047
Echinococcus granulosus Tubulin beta 2C chain 0.0066 0.0017 0.0017
Schistosoma mansoni brg-1 associated factor 0.0121 0.0171 0.0179
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0168 0.0304 0.0304
Mycobacterium tuberculosis Conserved hypothetical protein 0.0332 0.0766 1
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0303 0.545
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0081 0.0059 0.01
Toxoplasma gondii microneme protein MIC17C 0.0158 0.0277 0.0385
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0111 0.0144 0.1619
Brugia malayi Latrophilin receptor protein 2 0.0512 0.1275 0.2166
Schistosoma mansoni amine GPCR 0.0168 0.0304 0.033
Leishmania major beta tubulin 0.0066 0.0017 0.0064
Echinococcus granulosus beta tubulin 0.0066 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0065 0.0014 0.0024
Schistosoma mansoni hypothetical protein 0.0205 0.0408 0.0449
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0081 0.0059 0.0059
Echinococcus multilocularis neuropeptide FF receptor 2 0.0168 0.0304 0.0304
Schistosoma mansoni biogenic amine receptor 0.0168 0.0304 0.033
Onchocerca volvulus 0.0075 0.0041 0.0373
Loa Loa (eye worm) brahma associated protein 0.0121 0.0171 0.0291
Echinococcus granulosus allatostatin A receptor 0.0168 0.0304 0.0304
Loa Loa (eye worm) deoxyribonuclease II family protein 0.0071 0.003 0.0052
Echinococcus multilocularis FTZ F1 alpha 0.0081 0.0059 0.0059
Schistosoma mansoni protein kinase 0.0142 0.0231 0.0247
Plasmodium vivax hypothetical protein, conserved 0.0121 0.0171 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.015 0.0255
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0141 0.0228 0.0244
Onchocerca volvulus 0.0158 0.0277 0.2496
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0141 0.0228 0.0228
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0076 0.0045 0.0077
Schistosoma mansoni voltage-gated cation channel 0.0169 0.0308 0.0334
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Schistosoma mansoni hypothetical protein 0.0209 0.042 0.0463
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.0014 0.0024
Onchocerca volvulus 0.0158 0.0277 0.2496
Echinococcus multilocularis beta tubulin 0.0066 0.0017 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0137 0.014
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Loa Loa (eye worm) hypothetical protein 0.0096 0.0101 0.0172
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0144 0.1515
Echinococcus multilocularis SWI:SNF matrix associated 0.0121 0.0171 0.0171
Echinococcus multilocularis neuropeptide Y receptor 0.0168 0.0304 0.0304
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0081 0.0059 0.0051
Schistosoma mansoni retinoic acid receptor RXR 0.0081 0.0059 0.0051
Echinococcus multilocularis fmrfamide receptor 0.0168 0.0304 0.0304
Leishmania major heat shock protein 83-1 0.0069 0.0025 0.0113
Brugia malayi Melatonin receptor type 1A 0.0168 0.0304 0.0517
Echinococcus granulosus biogenic amine 5HT receptor 0.0168 0.0304 0.0304
Brugia malayi Serotonin receptor 0.0168 0.0304 0.0517
Trichomonas vaginalis heat shock protein, putative 0.0069 0.0025 0.0336
Brugia malayi MH2 domain containing protein 0.0144 0.0238 0.0404
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0141 0.0228 0.0228
Echinococcus granulosus peptide allatostatin:somatostatin 0.0168 0.0304 0.0304
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0137 0.2391
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0081 0.0059 0.0059
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0639 0.1632 0.1632
Echinococcus multilocularis tubulin beta 1 chain 0.0066 0.0017 0.0017
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.028 0.0621 0.0621
Schistosoma mansoni histamine h1 receptor 0.0168 0.0304 0.033
Loa Loa (eye worm) hypothetical protein 0.0169 0.0308 0.0523
Echinococcus multilocularis g protein coupled receptor 0.0168 0.0304 0.0304
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0108 0.0137 0.0137
Loa Loa (eye worm) calcium channel 0.0169 0.0308 0.0523
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0255 0.055 0.0935
Brugia malayi Dopamine receptor 0.0168 0.0304 0.0517
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Brugia malayi Nuclear hormone receptor-like 1 0.0081 0.0059 0.01
Trichomonas vaginalis deoxyribonuclease II precursor, putative 0.0071 0.003 0.0433
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0304 0.033
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0142 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0065 0.0014 0.0024
Trichomonas vaginalis tubulin, putative 0.0066 0.0017 0.0191
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Schistosoma mansoni hypothetical protein 0.0512 0.1275 0.1436
Echinococcus multilocularis GPCR, family 2 0.0512 0.1275 0.1275
Echinococcus granulosus neuropeptide Y receptor 0.0168 0.0304 0.0304
Echinococcus granulosus Tubulin beta 2C chain 0.0066 0.0017 0.0017
Echinococcus granulosus SWI:SNF matrix associated 0.0121 0.0171 0.0171
Leishmania major heat shock protein 83-1 0.0069 0.0025 0.0113
Mycobacterium leprae conserved hypothetical protein 0.0332 0.0766 1
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Onchocerca volvulus 0.0168 0.0304 0.2743
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.055 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0121 0.0171 1
Echinococcus granulosus fmrfamide receptor 0.0168 0.0304 0.0304
Echinococcus multilocularis voltage dependent calcium channel 0.0169 0.0308 0.0308
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0141 0.0228 0.0388
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0076 0.0045 0.0035
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.028 0.0621 0.0621
Trypanosoma brucei calpain, putative 0.0111 0.0144 0.1515
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0141 0.0228 0.0388
Onchocerca volvulus Protein ultraspiracle homolog 0.0081 0.0059 0.0531
Brugia malayi Calcitonin receptor-like protein seb-1 0.1512 0.4095 0.6956
Brugia malayi Deoxyribonuclease II family protein 0.0071 0.003 0.0052
Schistosoma mansoni opsin-like receptor 0.0168 0.0304 0.033
Brugia malayi neuropeptide F receptor 0.0168 0.0304 0.0517
Echinococcus granulosus glycine receptor subunit alpha 1 0.0141 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Echinococcus granulosus tubulin subunit beta 0.0066 0.0017 0.0017
Brugia malayi RE15519p 0.0168 0.0304 0.0517
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0168 0.0304 0.033
Toxoplasma gondii hypothetical protein 0.0158 0.0277 0.0385
Schistosoma mansoni endoplasmin 0.0069 0.0025 0.0012
Onchocerca volvulus 0.0076 0.0045 0.0409
Schistosoma mansoni thyroid hormone receptor 0.0081 0.0059 0.0051
Loa Loa (eye worm) hypothetical protein 0.0076 0.0045 0.0077
Echinococcus multilocularis somatostatin receptor 0.0168 0.0304 0.0304
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0066 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0158 0.0277 0.047
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0137 0.2391
Trypanosoma brucei heat shock protein, putative 0.0069 0.0025 0.0094
Entamoeba histolytica hypothetical protein, conserved 0.0332 0.0766 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.0228 0.0388
Schistosoma mansoni hypothetical protein 0.0512 0.1275 0.1436
Leishmania major heat shock protein 83-1 0.0069 0.0025 0.0113
Echinococcus granulosus deoxyribonuclease ii 0.0071 0.003 0.003
Brugia malayi hypothetical protein 0.0168 0.0304 0.0517
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0304 0.033
Echinococcus granulosus rhodopsin orphan GPCR 0.0168 0.0304 0.0304
Brugia malayi brahma associated protein 60 kDa 0.0121 0.0171 0.0291
Echinococcus granulosus heat shock protein 90 0.0062 0.0007 0.0007
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0141 0.0228 0.0388
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Echinococcus multilocularis glycine receptor subunit beta 0.0141 0.0228 0.0228
Schistosoma mansoni growth hormone secretagogue receptor 0.0168 0.0304 0.033
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0166 0.0299 0.2698
Loa Loa (eye worm) hypothetical protein 0.0141 0.0228 0.0388
Echinococcus granulosus adenylate cyclase type IX 0.0084 0.0068 0.0068
Echinococcus granulosus tachykinin peptides receptor 99D 0.0168 0.0304 0.0304
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0639 0.1632 1
Onchocerca volvulus 0.0141 0.0228 0.2061
Schistosoma mansoni hypothetical protein 0.0362 0.0851 0.0953
Leishmania major heat shock protein 83-1 0.0069 0.0025 0.0113
Onchocerca volvulus 0.0081 0.0059 0.0531
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.0144 0.1515
Echinococcus multilocularis sodium channel protein 0.0639 0.1632 0.1632
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0144 0.0847
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0141 0.0228 0.0228
Loa Loa (eye worm) bone morphogenic protein 6 0.0123 0.0178 0.0303
Echinococcus granulosus voltage dependent calcium channel 0.0169 0.0308 0.0308
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0364 0.0857 1
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Trypanosoma brucei C-8 sterol isomerase, putative 0.0364 0.0857 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0081 0.0059 0.0059
Trichomonas vaginalis DNAse2-prov protein, putative 0.0071 0.003 0.0433
Loa Loa (eye worm) hypothetical protein 0.0076 0.0045 0.0077
Brugia malayi PAN domain containing protein 0.0158 0.0277 0.047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0304 0.0304
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0168 0.0304 0.033
Entamoeba histolytica protein kinase, putative 0.0108 0.0137 0.1597
Brugia malayi hypothetical protein 0.0168 0.0304 0.0517
Leishmania major C-8 sterol isomerase-like protein 0.0364 0.0857 0.523
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0123 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Echinococcus multilocularis beta tubulin 0.0066 0.0017 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0304 0.033
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0141 0.0228 0.0388
Onchocerca volvulus 0.0158 0.0277 0.2496
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0081 0.0059 0.01
Schistosoma mansoni hypothetical protein 0.008 0.0057 0.0049
Echinococcus multilocularis nmda type glutamate receptor 0.0113 0.0149 0.0149
Onchocerca volvulus 0.0168 0.0304 0.2743
Echinococcus granulosus 7TM GPCR rhodopsin 0.0168 0.0304 0.0304
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0168 0.0304 0.0517
Loa Loa (eye worm) G-protein coupled receptor 0.0168 0.0304 0.0517
Loa Loa (eye worm) BEN-1 protein 0.0066 0.0017 0.0029
Schistosoma mansoni nAChR subunit 0.0141 0.0228 0.0244
Echinococcus granulosus neuropeptide receptor A26 0.0668 0.1715 0.1715
Loa Loa (eye worm) steroid hormone receptor 0.0081 0.0059 0.01
Echinococcus granulosus glutamate NMDA receptor subunit 0.0267 0.0585 0.0585
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.055 1
Echinococcus multilocularis fmrfamide receptor 0.0168 0.0304 0.0304
Onchocerca volvulus 0.0077 0.0049 0.0445
Loa Loa (eye worm) hypothetical protein 0.0119 0.0167 0.0283
Schistosoma mansoni neuropeptide receptor 0.0168 0.0304 0.033
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0168 0.0304 0.033
Giardia lamblia Beta tubulin 0.0066 0.0017 0.5686
Entamoeba histolytica hypothetical protein 0.0076 0.0045 0.0376
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0304 0.033
Leishmania major heat shock protein 83-1 0.0069 0.0025 0.0113
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.028 0.0621 0.0621
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Echinococcus granulosus integrin alpha 3 0.0116 0.0159 0.0159
Onchocerca volvulus 0.0065 0.0014 0.0129
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0304 0.033
Echinococcus granulosus biogenic amine 5HT receptor 0.0168 0.0304 0.0304
Schistosoma mansoni alpha-1 adrenergic receptor 0.0168 0.0304 0.033
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0168 0.0304 0.0304
Echinococcus granulosus g protein coupled receptor 0.0168 0.0304 0.0304
Onchocerca volvulus Putative nachr subunit 0.028 0.0621 0.5603
Echinococcus granulosus heat shock protein 90 0.0069 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0453 0.1109 0.1883
Loa Loa (eye worm) hypothetical protein 0.0065 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0084 0.0067 0.0114
Brugia malayi Integrin alpha pat-2 precursor 0.0152 0.0259 0.044
Onchocerca volvulus 0.0168 0.0304 0.2743
Onchocerca volvulus 0.0453 0.1109 1
Leishmania major beta tubulin 0.0066 0.0017 0.0064
Echinococcus multilocularis G protein coupled receptor 139 0.0168 0.0304 0.0304
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0081 0.0059 0.0059
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0081 0.0059 0.0051
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0141 0.0228 0.0388
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0362 0.0851 0.0851
Entamoeba histolytica heat shock protein 90, putative 0.0069 0.0025 0.0105
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0304 0.0304
Onchocerca volvulus 0.0168 0.0304 0.2743
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0144 0.0847
Giardia lamblia Beta tubulin 0.0066 0.0017 0.5686
Leishmania major heat shock protein 83-1 0.0069 0.0025 0.0113
Brugia malayi hypothetical protein 0.0168 0.0304 0.0517
Schistosoma mansoni serine-type protease inhibitor 0.3179 0.8793 1
Echinococcus multilocularis tubulin subunit beta 0.0066 0.0017 0.0017
Plasmodium vivax endoplasmin, putative 0.0069 0.0025 0.0511
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0108 0.0137 0.0232
Brugia malayi PAN domain containing protein 0.0158 0.0277 0.047
Leishmania major beta tubulin 0.0066 0.0017 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0303 0.545
Leishmania major heat shock protein 83-1 0.0069 0.0025 0.0113
Loa Loa (eye worm) hypothetical protein 0.0141 0.0228 0.0388
Leishmania major beta tubulin 0.0066 0.0017 0.0064
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0141 0.0228 0.0388
Trichomonas vaginalis tubulin beta chain, putative 0.0066 0.0017 0.0191
Loa Loa (eye worm) latrophilin receptor protein 2 0.0512 0.1275 0.2166
Echinococcus granulosus 7tm_1 domain containing protein 0.0168 0.0304 0.0304
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0362 0.0851 0.0851
Onchocerca volvulus 0.0168 0.0304 0.2743
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0141 0.0228 0.0244
Loa Loa (eye worm) hypothetical protein 0.0065 0.0014 0.0024
Echinococcus multilocularis heat shock protein 90 0.0062 0.0007 0.0007
Echinococcus multilocularis geminin 0.0205 0.0408 0.0408
Brugia malayi hypothetical protein 0.1216 0.326 0.5537
Echinococcus multilocularis endoplasmin 0.0062 0.0007 0.0007
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0108 0.0137 0.0232
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0362 0.0851 0.1446
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0303 0.545
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0081 0.0059 0.01
Toxoplasma gondii subtilisin SUB12 0.0158 0.0277 0.0385
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0076 0.0045 0.0077
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0141 0.0228 0.0228
Onchocerca volvulus 0.0453 0.1109 1
Schistosoma mansoni integrin alpha-ps 0.0068 0.0023 0.001
Brugia malayi putative neuropeptide receptor 0.0168 0.0304 0.0517
Schistosoma mansoni opsin-like receptor 0.0168 0.0304 0.033
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0076 0.0045 0.0077
Loa Loa (eye worm) adenylyl cyclase 3 0.0142 0.023 0.0391
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0065 0.0014 0.0014
Loa Loa (eye worm) ACC-1 protein 0.0141 0.0228 0.0388
Echinococcus multilocularis ecdysone induced protein 78C 0.0081 0.0059 0.0059
Entamoeba histolytica heat shock protein 90, putative 0.0069 0.0025 0.0105
Onchocerca volvulus Neuropeptide F receptor homolog 0.0168 0.0304 0.2743
Leishmania major heat shock protein 83-1 0.0069 0.0025 0.0113
Schistosoma mansoni RAR-like nuclear receptor 0.0081 0.0059 0.0051
Echinococcus granulosus nAChR subunit 0.0141 0.0228 0.0228
Onchocerca volvulus 0.0158 0.0277 0.2496
Echinococcus multilocularis deoxyribonuclease ii 0.0071 0.003 0.003
Schistosoma mansoni tubulin subunit beta 0.0066 0.0017 0.0003
Loa Loa (eye worm) ACC-1 protein 0.0141 0.0228 0.0388
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1697 0.4614 0.4614
Echinococcus granulosus rhodopsin orphan GPCR 0.0168 0.0304 0.0304
Onchocerca volvulus 0.0168 0.0304 0.2743
Loa Loa (eye worm) hypothetical protein 0.0158 0.0277 0.047
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0121 0.0171 0.0229
Loa Loa (eye worm) TYRA-2 protein 0.0168 0.0304 0.0517
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Echinococcus multilocularis g protein coupled receptor 0.0168 0.0304 0.0304
Loa Loa (eye worm) PAN domain-containing protein 0.0158 0.0277 0.047
Echinococcus granulosus G protein coupled receptor 139 0.0168 0.0304 0.0304
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0081 0.0059 0.01
Leishmania major heat shock protein 83-1 0.0069 0.0025 0.0113
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0081 0.006 0.0703
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0168 0.0304 0.033
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Echinococcus granulosus rhodopsin orphan GPCR 0.0168 0.0304 0.0304
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0141 0.0228 0.0388
Loa Loa (eye worm) hypothetical protein 0.0081 0.0059 0.01
Loa Loa (eye worm) deoxyribonuclease II family protein 0.0071 0.003 0.0052
Loa Loa (eye worm) heat shock protein 90 0.0069 0.0025 0.0043
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0115 0.0155 0.0263
Schistosoma mansoni protein kinase 0.0142 0.0231 0.0247
Loa Loa (eye worm) hypothetical protein 0.0523 0.1306 0.2219
Brugia malayi PAN domain containing protein 0.0158 0.0277 0.047
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0081 0.0059 0.01
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0141 0.0228 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0081 0.0059 0.01
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0062 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0065 0.0014 0.0024
Brugia malayi hypothetical protein 0.0065 0.0014 0.0024
Echinococcus granulosus nAChR subunit 0.0076 0.0045 0.0045
Echinococcus granulosus rhodopsin orphan GPCR 0.0168 0.0304 0.0304
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0111 0.0144 0.1619
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Echinococcus multilocularis serotonin receptor 0.0168 0.0304 0.0304
Echinococcus granulosus alpha 1A adrenergic receptor 0.0168 0.0304 0.0304
Brugia malayi Tachykinin-like peptides receptor 99D 0.0168 0.0304 0.0517
Brugia malayi Dopamine receptor protein 2 0.0168 0.0304 0.0517
Trypanosoma brucei heat shock protein, putative 0.0069 0.0025 0.0094
Leishmania major hypothetical protein, conserved 0.0075 0.0041 0.0213
Brugia malayi putative neuropeptide receptor NPR1 0.0168 0.0304 0.0517
Onchocerca volvulus 0.0158 0.0277 0.2496
Brugia malayi Cation transporter family protein 0.0141 0.0228 0.0388
Loa Loa (eye worm) hypothetical protein 0.0141 0.0228 0.0388
Echinococcus multilocularis allatostatin A receptor 0.0168 0.0304 0.0304
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0141 0.0228 0.0388
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0141 0.0228 0.0388
Leishmania major heat shock protein 83-1 0.0069 0.0025 0.0113
Schistosoma mansoni nAChR subunit 0.0141 0.0228 0.0244
Loa Loa (eye worm) hypothetical protein 0.1216 0.326 0.5537
Brugia malayi excitatory GABA receptor EXP-1A 0.0141 0.0228 0.0388
Trypanosoma cruzi beta tubulin, putative 0.0066 0.0017 0.0122
Brugia malayi Cation transporter family protein 0.0141 0.0228 0.0388
Loa Loa (eye worm) hypothetical protein 0.028 0.0621 0.1055
Loa Loa (eye worm) hypothetical protein 0.0081 0.0059 0.01
Echinococcus granulosus geminin 0.0205 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Schistosoma mansoni nAChR subunit 0.0141 0.0228 0.0244
Trypanosoma brucei Heat shock protein 83, putative 0.0069 0.0025 0.0094
Loa Loa (eye worm) hypothetical protein 0.0065 0.0014 0.0024
Leishmania major heat shock protein 83-1 0.0069 0.0025 0.0113
Loa Loa (eye worm) hypothetical protein 0.0065 0.0014 0.0024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0304 0.0304
Loa Loa (eye worm) neuropeptide F receptor 0.0168 0.0304 0.0517
Onchocerca volvulus 0.0158 0.0277 0.2496
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0141 0.0228 0.0228
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0512 0.1275 0.1275
Brugia malayi SWIB/MDM2 domain containing protein 0.0121 0.0171 0.0291
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0081 0.0059 0.01
Onchocerca volvulus 0.0453 0.1109 1
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Leishmania major beta tubulin 0.0066 0.0017 0.0064
Loa Loa (eye worm) hypothetical protein 0.0113 0.015 0.0255
Loa Loa (eye worm) tubulin beta-4 chain 0.0066 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0076 0.0045 0.0077
Loa Loa (eye worm) hypothetical protein 0.0141 0.0228 0.0388
Echinococcus multilocularis heat shock protein 90 0.0069 0.0025 0.0025
Schistosoma mansoni myosin xvIII 0.0168 0.0304 0.033
Loa Loa (eye worm) hypothetical protein 0.0388 0.0926 0.1572
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0076 0.0045 0.0077
Toxoplasma gondii PAN domain-containing protein 0.2456 0.6756 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.0144 0.1515
Leishmania major beta tubulin 0.0066 0.0017 0.0064
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.028 0.0621 0.0621
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0111 0.0144 0.1619
Brugia malayi hypothetical protein 0.0065 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0364 0.0857 0.1455
Schistosoma mansoni glutamate receptor NMDA 0.0267 0.0585 0.065
Leishmania major beta tubulin 0.0066 0.0017 0.0064
Echinococcus granulosus Tubulin beta 2C chain 0.0066 0.0017 0.0017
Echinococcus granulosus dro:myosuppressin receptor 0.0168 0.0304 0.0304
Onchocerca volvulus 0.0168 0.0304 0.2743
Echinococcus multilocularis Tubulin beta 2C chain 0.0066 0.0017 0.0017
Trypanosoma brucei heat shock protein, putative 0.0069 0.0025 0.0094
Loa Loa (eye worm) hypothetical protein 0.0163 0.0292 0.0496
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0168 0.0304 0.0304
Onchocerca volvulus 0.0168 0.0304 0.2743
Loa Loa (eye worm) hypothetical protein 0.0141 0.0228 0.0388
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0168 0.0304 0.0517
Brugia malayi hypothetical protein 0.0077 0.0049 0.0084
Brugia malayi G-protein coupled receptor 0.0168 0.0304 0.0517
Loa Loa (eye worm) tubulin beta-1 chain 0.0066 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0065 0.0014 0.0024
Echinococcus granulosus neuropeptide Y receptor 0.0168 0.0304 0.0304
Onchocerca volvulus 0.0076 0.0045 0.0409
Echinococcus multilocularis voltage dependent calcium channel 0.0169 0.0308 0.0308
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0168 0.0304 0.0304
Brugia malayi Serotonin receptor 0.0168 0.0304 0.0517
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0158 0.0277 0.0385
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0124 0.018 0.0306
Echinococcus granulosus glycine receptor subunit alpha 1 0.0141 0.0228 0.0228
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0081 0.006 0.0703
Mycobacterium ulcerans hypothetical protein 0.0332 0.0766 1
Toxoplasma gondii PAN domain-containing protein 0.0158 0.0277 0.0385
Brugia malayi G-protein coupled receptor 0.0168 0.0304 0.0517
Trypanosoma brucei heat shock protein 90, putative 0.0069 0.0025 0.0094
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0362 0.0851 0.0953
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0121 0.0171 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0141 0.0228 0.0388
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0168 0.0304 0.033
Leishmania major heat shock protein 83-1 0.0069 0.0025 0.0113
Echinococcus granulosus neuropeptides capa receptor 0.0168 0.0304 0.0304
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0512 0.1275 0.1275
Schistosoma mansoni adenoreceptor 0.0168 0.0304 0.033
Echinococcus multilocularis SWI:SNF matrix associated 0.0121 0.0171 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.0171 0.3028
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0168 0.0304 0.0304
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0169 0.0308 0.0308
Leishmania major beta tubulin 0.0066 0.0017 0.0064
Echinococcus granulosus GPCR family 2 0.0512 0.1275 0.1275
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.0303 0.2734
Schistosoma mansoni heat shock protein 0.0069 0.0025 0.0012
Schistosoma mansoni hypothetical protein 0.0205 0.0408 0.0449
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0303 0.545
Echinococcus granulosus tm gpcr rhodopsin 0.0168 0.0304 0.0304
Schistosoma mansoni nAChR subunit 0.0141 0.0228 0.0244
Brugia malayi hypothetical protein 0.0168 0.0304 0.0517
Loa Loa (eye worm) hypothetical protein 0.0076 0.0045 0.0077
Toxoplasma gondii hypothetical protein 0.0158 0.0277 0.0385
Loa Loa (eye worm) hypothetical protein 0.0076 0.0045 0.0077
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.055 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0065 0.0014 0.0024
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0169 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0065 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Leishmania major beta tubulin 0.0066 0.0017 0.0064
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.1148 0.3067 0.3067
Echinococcus multilocularis g protein coupled receptor 0.0168 0.0304 0.0304
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0304 0.0304
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0168 0.0304 0.033
Echinococcus granulosus endoplasmin 0.0062 0.0007 0.0007
Schistosoma mansoni deoxyribonuclease II-related 0.0071 0.003 0.0018
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0081 0.0059 0.0059
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.028 0.0621 0.1055
Echinococcus granulosus sodium channel protein 0.0639 0.1632 0.1632
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0329 0.5918
Loa Loa (eye worm) hypothetical protein 0.0512 0.1275 0.2166
Echinococcus granulosus heat shock protein 0.0069 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0065 0.0014 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0304 0.033
Echinococcus granulosus neuropeptide s receptor 0.0668 0.1715 0.1715
Schistosoma mansoni neuropeptide F-like receptor 0.0168 0.0304 0.033
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0303 0.545
Onchocerca volvulus 0.0158 0.0277 0.2496
Schistosoma mansoni neuropeptide F-like receptor 0.0168 0.0304 0.033
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0141 0.0228 0.0388
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0123 0.0178 0.0178
Schistosoma mansoni hypothetical protein 0.1 0.2651 0.3003
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0141 0.0228 0.0388
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0081 0.006 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0168 0.0304 0.033
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Brugia malayi Protein kinase domain containing protein 0.0075 0.0041 0.007
Loa Loa (eye worm) hypothetical protein 0.0141 0.0228 0.0388
Loa Loa (eye worm) endoplasmin 0.0069 0.0025 0.0043
Trichomonas vaginalis tubulin epsilon chain, putative 0.0066 0.0017 0.0191
Schistosoma mansoni amine GPCR 0.0168 0.0304 0.033
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0041 0.0407
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0169 0.0308 0.0334
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Echinococcus granulosus sex peptide receptor 0.0168 0.0304 0.0304
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0081 0.0059 0.0059
Echinococcus multilocularis thyroid hormone receptor alpha 0.0081 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Loa Loa (eye worm) hypothetical protein 0.0158 0.0277 0.047
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.028 0.0621 0.0621
Echinococcus granulosus tissue type plasminogen activator 0.0075 0.0041 0.0041
Onchocerca volvulus 0.0168 0.0304 0.2743
Echinococcus multilocularis neuropeptide receptor 0.0168 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Echinococcus multilocularis neuropeptides capa receptor 0.0168 0.0304 0.0304
Echinococcus multilocularis integrin alpha ps 0.0068 0.0023 0.0023
Onchocerca volvulus 0.0168 0.0304 0.2743
Loa Loa (eye worm) hypothetical protein 0.0141 0.0228 0.0388
Schistosoma mansoni amine GPCR 0.0168 0.0304 0.033
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0169 0.0308 0.0334
Mycobacterium ulcerans hypothetical protein 0.0332 0.0766 1
Brugia malayi hypothetical protein 0.0168 0.0304 0.0517
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0141 0.0228 0.0228
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0099 0.0109 0.0109
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0169 0.0308 0.0308
Brugia malayi hypothetical protein 0.0168 0.0304 0.0517
Echinococcus multilocularis jun protein 0.0099 0.0109 0.0109
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0168 0.0304 0.2743
Echinococcus granulosus glycine receptor subunit beta 0.0141 0.0228 0.0228
Echinococcus granulosus jun protein 0.0099 0.0109 0.0109
Schistosoma mansoni neuropeptide receptor 0.0168 0.0304 0.033
Echinococcus multilocularis G-protein coupled receptor, putative 0.0168 0.0304 0.0304
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0065 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0081 0.0059 0.0051
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0141 0.0228 0.0228
Brugia malayi follicle stimulating hormone receptor 0.0168 0.0304 0.0517
Echinococcus multilocularis Tubulin beta 2C chain 0.0066 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Echinococcus granulosus tubulin beta 4A class IVa 0.0066 0.0017 0.0017
Toxoplasma gondii PAN domain-containing protein 0.0158 0.0277 0.0385
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0081 0.0059 0.01
Mycobacterium tuberculosis Conserved protein 0.0332 0.0766 1
Leishmania major beta tubulin 0.0066 0.0017 0.0064
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0081 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Brugia malayi heat shock protein 90 0.0069 0.0025 0.0043
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0141 0.0228 0.0228
Echinococcus granulosus integrin alpha ps 0.0068 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0081 0.0059 0.01
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.0144 0.1515
Loa Loa (eye worm) TK/ROR protein kinase 0.0075 0.0041 0.007
Trypanosoma brucei heat shock protein, putative 0.0069 0.0025 0.0094
Brugia malayi G protein-coupled receptor 0.0168 0.0304 0.0517
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.0144 0.1515
Schistosoma mansoni hypothetical protein 0.0362 0.0851 0.0953
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0267 0.0585 0.0585
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0453 0.1109 0.1247
Trypanosoma brucei heat shock protein, putative 0.0069 0.0025 0.0094
Echinococcus granulosus tm gpcr rhodopsin 0.0168 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0453 0.1109 0.1883
Echinococcus multilocularis orexin receptor type 2 0.0168 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0075 0.0041 0.007
Schistosoma mansoni hypothetical protein 0.0168 0.0304 0.033
Loa Loa (eye worm) beta-tubulin 0.0066 0.0017 0.0029
Brugia malayi PAN domain containing protein 0.0158 0.0277 0.047
Onchocerca volvulus 0.0158 0.0277 0.2496
Loa Loa (eye worm) hypothetical protein 0.0141 0.0228 0.0388
Plasmodium falciparum heat shock protein 90 0.0069 0.0025 0.0511
Schistosoma mansoni hypothetical protein 0.0512 0.1275 0.1436
Giardia lamblia Heat shock protein HSP 90-alpha 0.0069 0.0025 1
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0169 0.0308 0.3461
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0108 0.0137 0.0137
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0303 0.545
Loa Loa (eye worm) acetylcholine receptor protein 0.0065 0.0014 0.0024
Chlamydia trachomatis SWIB complex protein 0.0121 0.0171 1
Loa Loa (eye worm) LGC-31 protein 0.0141 0.0228 0.0388
Brugia malayi Tubulin beta-1 chain 0.0066 0.0017 0.0029
Echinococcus granulosus hypothetical protein 0.0168 0.0304 0.0304
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0141 0.0228 0.0388
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0141 0.0228 0.0388
Brugia malayi steroid hormone receptor 0.0081 0.0059 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.055 1
Loa Loa (eye worm) PAN domain-containing protein 0.0158 0.0277 0.047
Schistosoma mansoni tubulin subunit beta 0.0066 0.0017 0.0003
Echinococcus granulosus FTZ F1 alpha 0.0081 0.0059 0.0059
Brugia malayi beta-tubulin, identical 0.0066 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Loa Loa (eye worm) hypothetical protein 0.0081 0.0059 0.01
Echinococcus granulosus rhodopsin orphan GPCR 0.0168 0.0304 0.0304
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0141 0.0228 0.0244
Echinococcus granulosus g-protein coupled receptor 0.0168 0.0304 0.0304
Leishmania major heat shock protein 83-1 0.0069 0.0025 0.0113
Schistosoma mansoni jun-related protein 0.008 0.0057 0.0049
Echinococcus granulosus nmda type glutamate receptor 0.0113 0.0149 0.0149
Echinococcus multilocularis SWI:SNF matrix associated 0.0121 0.0171 0.0171
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0168 0.0304 0.0517
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0168 0.0304 0.033
Trypanosoma cruzi heat shock protein 85, putative 0.0069 0.0025 0.0215
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0065 0.0014 0.0024
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0065 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0169 0.0308 0.3541
Loa Loa (eye worm) hypothetical protein 0.0141 0.0228 0.0388
Echinococcus multilocularis tissue type plasminogen activator 0.0075 0.0041 0.0041
Echinococcus granulosus voltage dependent calcium channel 0.0169 0.0308 0.0308
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0081 0.0059 0.0051
Echinococcus multilocularis neuropeptide receptor 0.0168 0.0304 0.0304
Leishmania major beta tubulin 0.0066 0.0017 0.0064
Toxoplasma gondii kringle domain-containing protein 0.0075 0.0041 0.0036
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0168 0.0304 0.0517
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1512 0.4095 0.6956
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0081 0.0059 0.01
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0124 0.018 0.0306
Trypanosoma brucei heat shock protein, putative 0.0069 0.0025 0.0094
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0512 0.1275 0.2166
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0168 0.0304 0.0304
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0168 0.0304 0.0304
Brugia malayi Transforming growth factor beta like domain containing protein 0.0123 0.0178 0.0303
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0141 0.0228 0.0388
Echinococcus multilocularis integrin alpha 3 0.0116 0.0159 0.0159
Schistosoma mansoni heat shock protein 0.0069 0.0025 0.0012
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0081 0.0059 0.0051
Schistosoma mansoni neuropeptide receptor 0.0168 0.0304 0.033
Leishmania major heat shock protein 83-1 0.0069 0.0025 0.0113
Brugia malayi Protein kinase domain containing protein 0.0108 0.0137 0.0232
Echinococcus granulosus Tubulin beta 2C chain 0.0066 0.0017 0.0017
Echinococcus multilocularis neuropeptides capa receptor 0.0168 0.0304 0.0304
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0168 0.0304 0.0304
Toxoplasma gondii PAN domain-containing protein 0.0158 0.0277 0.0385
Brugia malayi brahma associated protein 60 kDa 0.0121 0.0171 0.0291
Onchocerca volvulus 0.0168 0.0304 0.2743
Onchocerca volvulus 0.0065 0.0014 0.0129
Loa Loa (eye worm) hypothetical protein 0.0169 0.0308 0.0523
Loa Loa (eye worm) hypothetical protein 0.0081 0.0059 0.01
Brugia malayi G protein-coupled receptor F59B2.13 0.0168 0.0304 0.0517
Plasmodium vivax heat shock protein 86, putative 0.0069 0.0025 0.0511
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0081 0.0059 0.0059
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0304 0.0304
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0238 0.0404
Echinococcus multilocularis sex peptide receptor 0.0168 0.0304 0.0304
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.3607 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0168 0.0304 0.033
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0081 0.0059 0.0059
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0168 0.0304 0.0517
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0121 0.0171 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0081 0.0059 0.01
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0081 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0512 0.1275 0.1436
Echinococcus granulosus glycine receptor subunit beta 0.0141 0.0228 0.0228
Brugia malayi bZIP transcription factor family protein 0.0099 0.0109 0.0185
Trichomonas vaginalis tubulin alpha chain, putative 0.0066 0.0017 0.0191
Schistosoma mansoni hypothetical protein 0.0121 0.0171 0.0179
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.1148 0.3067 0.3067
Brugia malayi neuropeptide F receptor 0.0168 0.0304 0.0517
Toxoplasma gondii microneme protein MIC17A 0.0158 0.0277 0.0385
Loa Loa (eye worm) BEN-1 protein 0.0066 0.0017 0.0029
Trichomonas vaginalis tubulin gamma chain, putative 0.0066 0.0017 0.0191
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0168 0.0304 0.033
Loa Loa (eye worm) hypothetical protein 0.0141 0.0228 0.0388
Echinococcus multilocularis Tubulin beta 2C chain 0.0066 0.0017 0.0017
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0238 0.0404
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0168 0.0304 0.0304
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0168 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0065 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Loa Loa (eye worm) tubulin beta chain 0.0066 0.0017 0.0029
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0168 0.0304 0.0304
Echinococcus granulosus serotonin receptor 0.0168 0.0304 0.0304
Echinococcus multilocularis neuropeptide receptor A26 0.0668 0.1715 0.1715
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0137 0.2391
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.0144 0.1515
Schistosoma mansoni hypothetical protein 0.0121 0.0171 0.0179
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0169 0.0308 0.0523
Echinococcus granulosus neuropeptide receptor 0.0168 0.0304 0.0304
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0121 0.0171 0.0291
Toxoplasma gondii microneme protein, putative 0.0158 0.0277 0.0385
Toxoplasma gondii PAN domain-containing protein 0.2456 0.6756 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0014 0.0024
Schistosoma mansoni apoptosis regulator bax 0.0362 0.0851 0.0953
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0121 0.0171 0.0229
Onchocerca volvulus 0.0168 0.0304 0.2743
Leishmania major beta tubulin 0.0066 0.0017 0.0064
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0141 0.0228 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0081 0.0059 0.01
Brugia malayi hypothetical protein 0.0168 0.0304 0.0517
Loa Loa (eye worm) hypothetical protein 0.0141 0.0228 0.0388
Trypanosoma brucei heat shock protein 90, putative 0.0069 0.0025 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0081 0.0059 0.01
Schistosoma mansoni thyroid hormone receptor 0.0081 0.0059 0.0051
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0065 0.0014 0.0014
Giardia lamblia Beta tubulin 0.0066 0.0017 0.5686
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0168 0.0304 0.033
Toxoplasma gondii microneme protein MIC4 0.0158 0.0277 0.0385
Schistosoma mansoni nAChR subunit 0.0141 0.0228 0.0244
Echinococcus multilocularis neuropeptide s receptor 0.0668 0.1715 0.1715
Leishmania major beta tubulin 0.0066 0.0017 0.0064
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0169 0.0308 0.0308
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0168 0.0304 0.0304
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0168 0.0304 0.033
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0141 0.0228 0.0388
Loa Loa (eye worm) hypothetical protein 0.2148 0.5887 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0065 0.0014 0.0014
Echinococcus multilocularis nAChR subunit 0.0076 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0158 0.0277 0.047
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0081 0.0059 0.01
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0304 0.0304
Brugia malayi PAN domain containing protein 0.0158 0.0277 0.047
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0141 0.0228 0.0228
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0065 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517
Loa Loa (eye worm) PAN domain-containing protein 0.0158 0.0277 0.047
Schistosoma mansoni hypothetical protein 0.0168 0.0304 0.033
Schistosoma mansoni nuclear hormone receptor 0.0081 0.0059 0.0051
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0304 0.0304
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0081 0.0059 0.0051
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0168 0.0304 0.0304
Schistosoma mansoni amine GPCR 0.0168 0.0304 0.033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0304 0.033
Chlamydia trachomatis DNA topoisomerase I 0.0121 0.0171 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.0228 0.0388
Brugia malayi nuclear hormone receptor 0.0081 0.0059 0.01
Trypanosoma cruzi Heat shock protein 83, putative 0.0069 0.0025 0.0215
Echinococcus granulosus glycine receptor subunit alpha 1 0.0141 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0168 0.0304 0.0517

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2593 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 70.7946 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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