Detailed information for compound 1527464

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 379.903 | Formula: C15H26ClN3O4S
  • H donors: 4 H acceptors: 4 LogP: 0.76 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(C)C)NCCNCC(c1ccc(cc1)NS(=O)(=O)C)O.Cl
  • InChi: 1S/C15H25N3O4S.ClH/c1-11(2)15(20)17-9-8-16-10-14(19)12-4-6-13(7-5-12)18-23(3,21)22;/h4-7,11,14,16,18-19H,8-10H2,1-3H3,(H,17,20);1H
  • InChiKey: XVLBORPKVXREJX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni alpha-1 adrenergic receptor 0.0031 0.0142 0.0412
Echinococcus granulosus glutamate receptor subunit protein glur 0.0047 0.0235 0.0584
Echinococcus granulosus neuropeptide FF receptor 2 0.0031 0.0142 0.0351
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0019 0.0064 0.0515
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.001 0.0081
Onchocerca volvulus 0.0031 0.0142 0.1002
Schistosoma mansoni inositol monophosphatase 0.0037 0.0175 0.0509
Echinococcus granulosus allatostatin A receptor 0.0031 0.0142 0.0351
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Brugia malayi larval opioid receptor 0.0031 0.0142 0.1146
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0064 0.0064
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0009 0.0001 0.0008
Schistosoma mansoni protein kinase 0.0024 0.0095 0.0276
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0034 0.0362
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0142 0.0142
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0034 0.0362
Echinococcus multilocularis cpg binding protein 0.003 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0515
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0008
Loa Loa (eye worm) TYRA-2 protein 0.0031 0.0142 0.1146
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.0928 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0064 0.0185
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0008
Loa Loa (eye worm) RGC/RGC protein kinase 0.0024 0.0095 0.0768
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0014 0.0034 0.1394
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.001 0.001 0.0081
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0031 0.0142 0.1146
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0135 0.0394
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0515
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0024 0.0095 0.0768
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0153 0.1242
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0167 1
Echinococcus multilocularis sex peptide receptor 0.0031 0.0142 0.0142
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0175 0.3124
Echinococcus multilocularis tyrosine kinase 0.0024 0.0095 0.0095
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0031 0.0142 0.0412
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0151 0.1629
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0148 0.2649
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0229 0.0667
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0142 0.0412
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.029 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.033 0.0959
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0008
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0031 0.0142 0.0142
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0064 0.0515
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.001 0.001 0.0055
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0034 0.0186
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0229 0.057
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.001 0.001 0.0081
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0229 0.1858
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0034 0.0362
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0064 0.0185
Echinococcus multilocularis nAChR subunit 0.0019 0.0064 0.0064
Echinococcus multilocularis glutamate receptor 2 0.0071 0.0383 0.0383
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0211 0.0523
Echinococcus granulosus neuropeptide s receptor 0.0031 0.0142 0.0351
Echinococcus multilocularis G-protein coupled receptor, putative 0.0031 0.0142 0.0142
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0031 0.0142 0.0142
Echinococcus granulosus expressed conserved protein 0.0093 0.0523 0.1299
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0024 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0001 0.0008
Schistosoma mansoni glutamate receptor kainate 0.0047 0.0235 0.0684
Echinococcus multilocularis receptor type guanylyl cyclase 0.0024 0.0095 0.0095
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0063 0.3794
Onchocerca volvulus 0.0014 0.0034 0.0238
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0148 0.082
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0031 0.0142 0.0412
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.001 0.0345
Schistosoma mansoni biogenic amine receptor 0.0031 0.0142 0.0412
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0031 0.0142 0.1146
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Onchocerca volvulus 0.003 0.0135 0.0958
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0063 0.0449
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0229 0.0667
Schistosoma mansoni glutamate receptor AMPA 0.0047 0.0235 0.0684
Schistosoma mansoni hypothetical protein 0.0041 0.0201 0.0585
Schistosoma mansoni hypothetical protein 0.0041 0.0201 0.0585
Echinococcus granulosus glutamate receptor 2 0.0024 0.0095 0.0235
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0282 0.0282
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.0824 0.0824
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0175 0.124
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0034 0.0362
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0064 0.0158
Loa Loa (eye worm) hypothetical protein 0.0036 0.0167 0.1352
Schistosoma mansoni hypothetical protein 0.0409 0.247 0.7184
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0031 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0008
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0024 0.0095 0.0095
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0019 0.0064 0.0185
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0034 0.0362
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0019 0.0064 0.0515
Schistosoma mansoni nAChR subunit 0.0019 0.0064 0.0185
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0135 0.0135
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0034 0.0362
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0014 0.0034 0.1394
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0515
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0034 0.0362
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Brugia malayi hypothetical protein 0.0031 0.0142 0.1146
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0209 0.1156
Chlamydia trachomatis glutamine binding protein 0.012 0.0685 1
Loa Loa (eye worm) MBCTL1 0.0054 0.0282 0.2286
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0241 0.2598
Loa Loa (eye worm) hypothetical protein 0.0024 0.0095 0.0768
Brugia malayi Pre-SET motif family protein 0.003 0.0135 0.1096
Echinococcus granulosus receptor type guanylyl cyclase 0.0024 0.0095 0.0235
Schistosoma mansoni amine GPCR 0.0031 0.0142 0.0412
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0019 0.0064 0.0158
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0064 0.0515
Schistosoma mansoni nAChR subunit 0.0019 0.0064 0.0185
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0009 0.0001 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0034 0.0272
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0001 0.0008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0229 0.0667
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0211 0.0523
Schistosoma mansoni nAChR subunit 0.0019 0.0064 0.0185
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0034 0.0362
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0034 0.0272
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0148 0.082
Schistosoma mansoni amine GPCR 0.0031 0.0142 0.0412
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0282 0.0821
Schistosoma mansoni acetylcholine receptor subunit beta 0.0009 0.0001 0.0003
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0241 0.1333
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0142 0.0351
Echinococcus granulosus glutamate receptor 2 0.0071 0.0383 0.095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0142 0.0412
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0031 0.0142 0.1146
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0241 0.2598
Loa Loa (eye worm) hypothetical protein 0.0048 0.0241 0.1954
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0064 0.0064
Mycobacterium ulcerans hypothetical protein 0.0048 0.0241 0.2598
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0515
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0241 0.2598
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0009 0.0001 0.0008
Schistosoma mansoni hypothetical protein 0.0031 0.0142 0.0412
Echinococcus multilocularis fmrfamide receptor 0.0031 0.0142 0.0142
Loa Loa (eye worm) G-protein coupled receptor 0.0031 0.0142 0.1146
Schistosoma mansoni metabotropic glutamate receptor 0.0024 0.0095 0.0276
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0019 0.0064 0.0515
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0071 0.0383 0.0383
Onchocerca volvulus 0.0048 0.0241 0.1708
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Echinococcus granulosus G protein coupled receptor 139 0.0031 0.0142 0.0351
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.181 1
Brugia malayi Glutamate receptor 1 precursor 0.0047 0.0235 0.1904
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0229 0.1858
Onchocerca volvulus 0.0009 0.0001 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0155 0.1669
Mycobacterium ulcerans hypothetical protein 0.0159 0.0928 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.027 0.2185
Schistosoma mansoni nAChR subunit 0.0009 0.0001 0.0003
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.012 0.0685 1
Schistosoma mansoni amine GPCR 0.0031 0.0142 0.0412
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0009 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0095 0.0768
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0064 0.0064
Brugia malayi AKH receptor 0.0031 0.0142 0.1146
Echinococcus granulosus neuropeptide receptor 0.0031 0.0142 0.0351
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0019 0.0064 0.0515
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0142 0.0412
Brugia malayi Cation transporter family protein 0.0019 0.0064 0.0515
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0515
Brugia malayi G-protein coupled receptor 0.0031 0.0142 0.1146
Onchocerca volvulus 0.0031 0.0142 0.1002
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.113 0.113
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0063 0.035
Echinococcus granulosus fmrfamide receptor 0.0031 0.0142 0.0351
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0241 0.4303
Brugia malayi neuropeptide F receptor 0.0031 0.0142 0.1146
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0034 0.0186
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Schistosoma mansoni hypothetical protein 0.0047 0.0235 0.0684
Echinococcus granulosus sex peptide receptor 0.0031 0.0142 0.0351
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0019 0.0064 0.0515
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0047 0.0235 0.0584
Schistosoma mansoni biogenic amine receptor 0.0031 0.0142 0.0412
Schistosoma mansoni hypothetical protein 0.0041 0.0201 0.0585
Brugia malayi follicle stimulating hormone receptor 0.0031 0.0142 0.1146
Brugia malayi Dopamine receptor protein 1 0.0031 0.0142 0.1146
Brugia malayi hypothetical protein 0.0089 0.0496 0.4019
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0063 1
Echinococcus granulosus atrial natriuretic peptide receptor 0.0024 0.0095 0.0235
Echinococcus multilocularis glutamate receptor 2 0.0047 0.0235 0.0235
Brugia malayi excitatory GABA receptor EXP-1A 0.0019 0.0064 0.0515
Trichomonas vaginalis rotamase, putative 0.0033 0.0148 0.1052
Onchocerca volvulus 0.001 0.001 0.0071
Schistosoma mansoni acetylcholine receptor-related 0.0009 0.0001 0.0003
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0024 0.0095 0.0768
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0024 0.0095 0.0095
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0242 0.1956
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.113 0.2805
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0081
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0063 0.0449
Schistosoma mansoni ap endonuclease 0.0019 0.0063 0.0184
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0175 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0031 0.0142 0.0351
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0561 0.1392
Loa Loa (eye worm) hypothetical protein 0.0054 0.0282 0.2286
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0034 0.0362
Onchocerca volvulus 0.0031 0.0142 0.1002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0063 0.0157
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Schistosoma mansoni rotamase 0.0033 0.0153 0.0446
Onchocerca volvulus 0.0031 0.0142 0.1002
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0034 0.0272
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0211 0.1705
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Schistosoma mansoni opsin-like receptor 0.0031 0.0142 0.0412
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0019 0.0064 0.0515
Onchocerca volvulus 0.0031 0.0142 0.1002
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0175 0.0435
Onchocerca volvulus 0.0019 0.0064 0.0451
Loa Loa (eye worm) hypothetical protein 0.0036 0.0167 0.1352
Schistosoma mansoni neuropeptide receptor 0.0031 0.0142 0.0412
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0241 0.2598
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0034 0.0186
Onchocerca volvulus 0.001 0.001 0.0071
Loa Loa (eye worm) hypothetical protein 0.0089 0.0496 0.4019
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0515
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0241 0.4303
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0019 0.0064 0.0515
Schistosoma mansoni neuropeptide F-like receptor 0.0031 0.0142 0.0412
Echinococcus granulosus 7TM GPCR rhodopsin 0.0031 0.0142 0.0351
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0175 0.124
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0019 0.0064 0.0064
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0155 0.1669
Echinococcus multilocularis neuropeptide Y receptor 0.0031 0.0142 0.0142
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0175 0.0968
Schistosoma mansoni nAChR subunit 0.0019 0.0064 0.0185
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0009 0.0001 0.0001
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0031 0.0142 0.0412
Echinococcus granulosus glutamate receptor NMDA 0.0495 0.3003 0.7455
Echinococcus granulosus nAChR subunit 0.001 0.001 0.0025
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0515
Echinococcus granulosus g-protein coupled receptor 0.0031 0.0142 0.0351
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Onchocerca volvulus 0.0048 0.0242 0.171
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Loa Loa (eye worm) glutamate receptor 1 0.0047 0.0235 0.1904
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0241 0.2598
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Echinococcus granulosus neuropeptides capa receptor 0.0031 0.0142 0.0351
Schistosoma mansoni cpg binding protein 0.0029 0.0124 0.0362
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0063 0.0063
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.247 0.247
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0031 0.0142 0.0412
Schistosoma mansoni neuropeptide F-like receptor 0.0031 0.0142 0.0412
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Schistosoma mansoni growth hormone secretagogue receptor 0.0031 0.0142 0.0412
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0241 0.1333
Echinococcus granulosus serotonin receptor 0.0031 0.0142 0.0351
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0064 0.0515
Toxoplasma gondii hypothetical protein 0.0049 0.0248 0.8553
Brugia malayi G protein-coupled receptor 0.0031 0.0142 0.1146
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0272
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0034 0.0362
Onchocerca volvulus 0.0031 0.0142 0.1002
Schistosoma mansoni amine GPCR 0.0031 0.0142 0.0412
Schistosoma mansoni opsin-like receptor 0.0031 0.0142 0.0412
Echinococcus multilocularis somatostatin receptor 0.0031 0.0142 0.0142
Brugia malayi hypothetical protein 0.0031 0.0142 0.1146
Onchocerca volvulus 0.0019 0.0064 0.0451
Brugia malayi mbt repeat family protein 0.0048 0.0242 0.1956
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0009 0.0001 0.0002
Echinococcus granulosus nmda type glutamate receptor 0.0519 0.315 0.7821
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0034 0.0362
Brugia malayi hypothetical protein 0.0031 0.0142 0.1146
Brugia malayi hypothetical protein 0.0009 0.0001 0.0008
Echinococcus multilocularis neuropeptide Y receptor 0.0031 0.0142 0.0142
Loa Loa (eye worm) RGC/RGC protein kinase 0.0024 0.0095 0.0768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0229 0.0229
Schistosoma mansoni nAChR subunit 0.0009 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Brugia malayi Glutamate receptor 2 precursor 0.0047 0.0235 0.1904
Brugia malayi hypothetical protein 0.0031 0.0142 0.1146
Schistosoma mansoni glutamate receptor NMDA 0.0047 0.0235 0.0684
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0064 0.0515
Echinococcus multilocularis glutamate receptor NMDA 0.0495 0.3003 0.3003
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0142 0.0142
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0031 0.0142 0.0412
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0064 0.0158
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0034 0.0362
Echinococcus granulosus 7tm_1 domain containing protein 0.0031 0.0142 0.0351
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0047 0.0235 0.0584
Loa Loa (eye worm) LGC-31 protein 0.0019 0.0064 0.0515
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0063 0.0513
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0034 0.0186
Onchocerca volvulus 0.0024 0.0095 0.0672
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0034 0.0186
Schistosoma mansoni patched 1 0.0043 0.0211 0.0612
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0515
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0241 0.4303
Echinococcus multilocularis serotonin receptor 0.0031 0.0142 0.0142
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0063 0.323
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0034 0.0362
Brugia malayi neuropeptide F receptor 0.0031 0.0142 0.1146
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0034 0.0362
Loa Loa (eye worm) hypothetical protein 0.0048 0.0242 0.1956
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0175 0.6046
Echinococcus granulosus glutamate NMDA receptor subunit 0.0047 0.0235 0.0584
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0561 1
Schistosoma mansoni opsin-like receptor 0.0031 0.0142 0.0412
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Onchocerca volvulus 0.0031 0.0142 0.1002
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0175 0.1886
Onchocerca volvulus 0.0031 0.0142 0.1002
Echinococcus granulosus hypothetical protein 0.0031 0.0142 0.0351
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0167 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.181 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0241 0.2598
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0515
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0047 0.0235 0.0235
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0267 0.1473
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0034 0.0362
Onchocerca volvulus 0.0024 0.0095 0.0672
Onchocerca volvulus 0.0031 0.0142 0.1002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0063 0.035
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0142 0.0351
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0515
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0063 0.113
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0153 0.1086
Echinococcus multilocularis fmrfamide receptor 0.0031 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0008
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0142 0.0351
Loa Loa (eye worm) GABA receptor subunit 0.001 0.001 0.0081
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0153 0.1242
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0034 0.0186
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0031 0.0142 0.1146
Loa Loa (eye worm) neuropeptide F receptor 0.0031 0.0142 0.1146
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0135 0.0336
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Loa Loa (eye worm) hypothetical protein 0.0089 0.0496 0.4019
Schistosoma mansoni biogenic amine receptor 0.0031 0.0142 0.0412
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0009 0.0001 0.0001
Brugia malayi Guanylyl cyclase protein 23 0.0024 0.0095 0.0768
Brugia malayi Cation transporter family protein 0.0019 0.0064 0.0515
Schistosoma mansoni metabotropic glutamate receptor 0.0024 0.0095 0.0276
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0031 0.0142 0.0142
Echinococcus granulosus biogenic amine 5HT receptor 0.0031 0.0142 0.0351
Brugia malayi hypothetical protein 0.0031 0.0142 0.1146
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0515
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0034 0.0362
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0124 0.1008
Echinococcus multilocularis G protein coupled receptor 139 0.0031 0.0142 0.0142
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0034 0.0362
Schistosoma mansoni neurotransmitter gated ion channel 0.0009 0.0001 0.0003
Schistosoma mansoni neuropeptide receptor 0.0031 0.0142 0.0412
Onchocerca volvulus 0.0019 0.0064 0.0451
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0009 0.0022
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0009 0.0001 0.0008
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0024 0.0095 0.0768
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0008
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0064 0.0185
Echinococcus granulosus somatostatin receptor 0.0031 0.0142 0.0351
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0034 0.0362
Echinococcus multilocularis protein patched 0.0043 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0081
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0034 0.1161
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0019 0.0064 0.0158
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0142 0.0351
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0209 0.1156
Onchocerca volvulus 0.0031 0.0142 0.1002
Schistosoma mansoni glutamate receptor kainate 0.0047 0.0235 0.0684
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0064 0.0064
Entamoeba histolytica hypothetical protein 0.0024 0.0095 0.1692
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0071 0.0383 0.095
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0019 0.0064 0.0064
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0031 0.0142 0.0412
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0142 0.0412
Loa Loa (eye worm) hypothetical protein 0.0024 0.0095 0.0768
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0515
Trypanosoma cruzi extracellular receptor, putative 0.0024 0.0095 0.0524
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0034 0.0186
Loa Loa (eye worm) hypothetical protein 0.0024 0.0095 0.0768
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0008
Brugia malayi Dopamine receptor protein 2 0.0031 0.0142 0.1146
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0019 0.0064 0.0064
Schistosoma mansoni glutamate receptor AMPA 0.0047 0.0235 0.0684
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0515
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0008
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0034 0.0272
Onchocerca volvulus 0.0014 0.0034 0.0238
Loa Loa (eye worm) glutamate receptor 0.0024 0.0095 0.0768
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0142 0.0412
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0063 0.0682
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0034 0.0362
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0272
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0063 0.0682
Echinococcus granulosus orexin receptor type 2 0.0031 0.0142 0.0351
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.001 0.001 0.0029
Onchocerca volvulus 0.0019 0.0064 0.0451
Brugia malayi CXXC zinc finger family protein 0.0029 0.0124 0.1008
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0009 0.0001 0.0002
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0031 0.0142 0.0351
Brugia malayi hypothetical protein 0.0009 0.0001 0.0008
Echinococcus granulosus nAChR subunit 0.0019 0.0064 0.0158
Entamoeba histolytica hypothetical protein 0.001 0.001 0.0178
Echinococcus granulosus neuropeptide receptor 0.0031 0.0142 0.0351
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0034 0.0186
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0148 0.5126
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0081
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0125 0.031
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0167 0.1798
Onchocerca volvulus 0.0029 0.0124 0.0881
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Onchocerca volvulus 0.0031 0.0142 0.1002
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0019 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0081
Loa Loa (eye worm) hypothetical protein 0.0024 0.0095 0.0768
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Schistosoma mansoni hypothetical protein 0.0031 0.0142 0.0412
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.057 0.1658
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0019 0.0064 0.0158
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0148 0.082
Echinococcus granulosus tyrosine kinase 0.0024 0.0095 0.0235
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0071 0.0383 0.095
Brugia malayi hypothetical protein 0.0031 0.0142 0.1146
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0019 0.0064 0.0515
Brugia malayi Receptor family ligand binding region containing protein 0.0024 0.0095 0.0768
Toxoplasma gondii exonuclease III APE 0.0019 0.0063 0.2186
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0175 0.0968
Loa Loa (eye worm) inositol-1 0.0037 0.0175 0.1418
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0151 0.627
Schistosoma mansoni glutamate receptor kainate 0.0047 0.0235 0.0684
Schistosoma mansoni cpg binding protein 0.003 0.0135 0.0391
Echinococcus granulosus neuropeptides capa receptor 0.0031 0.0142 0.0351
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.1235 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0241 0.2598
Echinococcus multilocularis expressed conserved protein 0.0093 0.0523 0.0523
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0142 0.0142
Echinococcus granulosus cpg binding protein 0.003 0.0135 0.0334
Schistosoma mansoni amine GPCR 0.0031 0.0142 0.0412
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0209 0.1156
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0081
Echinococcus granulosus dnaJ subfamily B 0.0409 0.247 0.6132
Brugia malayi hypothetical protein 0.0009 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0008
Brugia malayi Receptor family ligand binding region containing protein 0.0024 0.0095 0.0768
Brugia malayi G-protein coupled receptor 0.0031 0.0142 0.1146
Schistosoma mansoni hypothetical protein 0.0031 0.0142 0.0412
Brugia malayi CHE-14 protein 0.0043 0.0211 0.1705
Loa Loa (eye worm) hypothetical protein 0.0024 0.0095 0.0768
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0081
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0031 0.0142 0.0351
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0031 0.0142 0.1146
Echinococcus granulosus nmda type glutamate receptor 0.0662 0.4028 1
Loa Loa (eye worm) neuropeptide F receptor 0.0031 0.0142 0.1146
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0034 0.0272
Echinococcus multilocularis orexin receptor type 2 0.0031 0.0142 0.0142
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0142 0.0142
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0167 0.1798
Echinococcus granulosus metabotropic glutamate receptor 5 0.0024 0.0095 0.0235
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0047 0.0235 0.0584
Schistosoma mansoni neuropeptide f receptor 76f 0.0031 0.0142 0.0412
Echinococcus granulosus dro:myosuppressin receptor 0.0031 0.0142 0.0351
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0081
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.181 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0142 0.0351
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0064 0.0158
Echinococcus multilocularis neuropeptide receptor A26 0.0031 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0036 0.0167 0.1352
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0561 0.4541
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0142 0.0142
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0024 0.0095 0.0768
Onchocerca volvulus 0.0031 0.0142 0.1002
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0031 0.0142 0.0412
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.001 0.001 0.0055
Loa Loa (eye worm) hypothetical protein 0.0036 0.0167 0.1352
Leishmania major extracellular receptor, putative 0.0024 0.0095 0.0524
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0031 0.0142 0.0412
Schistosoma mansoni histamine h1 receptor 0.0031 0.0142 0.0412
Onchocerca volvulus 0.0009 0.0001 0.0007
Loa Loa (eye worm) G-protein coupled receptor 0.0031 0.0142 0.1146
Brugia malayi hypothetical protein 0.0009 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0081
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0515
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0071 0.0383 0.0383
Echinococcus multilocularis serotonin receptor 0.0031 0.0142 0.0142
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0019 0.0064 0.0185
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0031 0.0142 0.1146
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0024 0.0095 0.0768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0155 0.1669
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0064 0.0158
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.001 0.0081
Echinococcus multilocularis NMDA receptor 0.0047 0.0235 0.0235
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0135 0.0394
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0034 0.0362
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0034 0.0186
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0031 0.0142 0.0351
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.001 0.001 0.0055
Loa Loa (eye worm) hypothetical protein 0.0099 0.0561 0.4541
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0064 0.0064
Schistosoma mansoni glutamate receptor NMDA 0.0566 0.3438 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0242 0.06
Onchocerca volvulus 0.0009 0.0001 0.0007
Echinococcus multilocularis neuropeptides capa receptor 0.0031 0.0142 0.0142
Brugia malayi hypothetical protein 0.0031 0.0142 0.1146
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0515
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0064 0.0515
Echinococcus multilocularis dro:myosuppressin receptor 0.0031 0.0142 0.0142
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0047 0.0235 0.0235
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0034 0.2015
Schistosoma mansoni ATP-binding cassette transporter 0.0047 0.0235 0.0684
Schistosoma mansoni tyrosine kinase 0.0024 0.0095 0.0276
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0019 0.0064 0.0185
Echinococcus granulosus g protein coupled receptor 0.0031 0.0142 0.0351
Loa Loa (eye worm) hypothetical protein 0.0048 0.0241 0.1954
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0515
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0241 0.2598
Echinococcus multilocularis nmda type glutamate receptor 0.0519 0.315 0.315
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0034 0.0084
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0019 0.0064 0.0515
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0019 0.0064 0.0158
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0064 0.0515
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.181 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0142 0.0412
Echinococcus granulosus alpha 1A adrenergic receptor 0.0031 0.0142 0.0351
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Brugia malayi GnHR receptor homolog 0.0031 0.0142 0.1146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0142 0.0412
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0515
Loa Loa (eye worm) hypothetical protein 0.003 0.0135 0.1096
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0142 0.0412
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0034 0.0272
Loa Loa (eye worm) acetylcholine receptor protein 0.0009 0.0001 0.0008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0063 0.035
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0034 0.0362
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0064 0.0064
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0829 0.4579
Brugia malayi Cation transporter family protein 0.0019 0.0064 0.0515
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0019 0.0064 0.0515
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0211 0.1491
Brugia malayi metabotropic glutamate receptor type 2 0.0024 0.0095 0.0768
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0064 0.0515
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.0824 0.2045
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0019 0.0064 0.0515
Brugia malayi hypothetical protein 0.0031 0.0142 0.1146
Brugia malayi Melatonin receptor type 1A 0.0031 0.0142 0.1146
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0142 0.0142
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0008 0.0067
Schistosoma mansoni ap endonuclease 0.0019 0.0063 0.0184
Schistosoma mansoni biogenic amine (5HT) receptor 0.0031 0.0142 0.0412
Loa Loa (eye worm) RGC/RGC protein kinase 0.0024 0.0095 0.0768
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0014 0.0034 0.1394
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0063 0.0925
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0034 0.0362
Echinococcus granulosus metabotropic glutamate receptor 2 0.0024 0.0095 0.0235
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0241 0.1333
Echinococcus multilocularis g-protein coupled receptor 0.0031 0.0142 0.0142
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0175 0.0175
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0034 0.0362
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0031 0.0142 0.1146
Brugia malayi putative neuropeptide receptor NPR1 0.0031 0.0142 0.1146
Onchocerca volvulus 0.0031 0.0142 0.1002
Onchocerca volvulus 0.0019 0.0064 0.0451
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0064 0.0515
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0242 0.06
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0242 0.0702
Onchocerca volvulus 0.0031 0.0142 0.1002
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0167 0.2438
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.001 0.0055
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0561 0.0561
Schistosoma mansoni myosin xvIII 0.0031 0.0142 0.0412
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0064 0.0158
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0034 0.0362
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0829 0.4579
Onchocerca volvulus 0.0014 0.0034 0.0238
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0241 0.1954
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0064 0.0158
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0142 0.0351
Brugia malayi Serotonin receptor 0.0031 0.0142 0.1146
Schistosoma mansoni biogenic amine (5HT) receptor 0.0031 0.0142 0.0412
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0241 0.1954
Brugia malayi RE15519p 0.0031 0.0142 0.1146
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Echinococcus multilocularis allatostatin A receptor 0.0031 0.0142 0.0142
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0241 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0034 0.0362
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0175 0.0968
Brugia malayi G protein-coupled receptor F59B2.13 0.0031 0.0142 0.1146
Brugia malayi Serotonin receptor 0.0031 0.0142 0.1146
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0034 0.0362
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0142 0.0351
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0142 0.0412
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0064 0.0515
Brugia malayi hypothetical protein 0.0024 0.0095 0.0768
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0031 0.0142 0.1146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0142 0.0412
Echinococcus multilocularis neuropeptide FF receptor 2 0.0031 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0048 0.0241 0.1954
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0031 0.0142 0.0412
Brugia malayi hypothetical protein 0.0009 0.0001 0.0008
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0031 0.0142 0.0351
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0242 0.0702
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0142 0.0142
Onchocerca volvulus Putative nachr subunit 0.0019 0.0064 0.0451
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0081
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0034 0.06
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Plasmodium vivax SET domain protein, putative 0.003 0.0135 0.8105
Onchocerca volvulus Neuropeptide F receptor homolog 0.0031 0.0142 0.1002
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0241 0.1954
Brugia malayi hypothetical protein 0.0031 0.0142 0.1146
Onchocerca volvulus 0.0014 0.0034 0.0238
Loa Loa (eye worm) melatonin receptor type 1A 0.0031 0.0142 0.1146
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0047 0.0235 0.0235
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0071 0.0383 0.095
Echinococcus granulosus neuropeptide Y receptor 0.0031 0.0142 0.0351
Schistosoma mansoni nAChR subunit 0.0019 0.0064 0.0185
Loa Loa (eye worm) hypothetical protein 0.0036 0.0167 0.1352
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0031 0.0142 0.0142
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0034 0.0238
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0209 0.1156
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0031 0.0142 0.0142
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0024 0.0095 0.0672
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0009 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0095 0.0768
Echinococcus multilocularis glutamate receptor 2 0.0024 0.0095 0.0095
Onchocerca volvulus 0.0237 0.1412 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0142 0.0351
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0242 0.171
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0142 0.0412
Onchocerca volvulus 0.0031 0.0142 0.1002
Echinococcus granulosus neuropeptide receptor A26 0.0031 0.0142 0.0351
Schistosoma mansoni hypothetical protein 0.0031 0.0142 0.0412
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0135 0.0394
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0034 0.0098
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0031 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0031 0.0142 0.1146
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0282 0.0701
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0166 0.0973 0.0973
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0142 0.0351
Loa Loa (eye worm) oxidoreductase 0.0014 0.0034 0.0272
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0155 0.1669
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0019 0.0064 0.0158
Echinococcus multilocularis neuropeptide s receptor 0.0031 0.0142 0.0142
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0071 0.0383 0.0383
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0241 0.2598
Schistosoma mansoni hypothetical protein 0.0041 0.0201 0.0585
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0034 0.0272
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Schistosoma mansoni eyes absent homolog 0.0089 0.0496 0.1443
Schistosoma mansoni hypothetical protein 0.0294 0.1759 0.5116
Schistosoma mansoni neurotransmitter gated ion channel 0.001 0.001 0.0029
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Brugia malayi Tachykinin-like peptides receptor 99D 0.0031 0.0142 0.1146
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0034 0.0238
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0031 0.0142 0.0142
Echinococcus multilocularis expressed protein 0.0033 0.0153 0.0153
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0064 0.0515
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0515
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0175 0.0968
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0031 0.0142 0.0142
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0148 0.082
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0829 0.4579
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0242 0.0702
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0031 0.0142 0.0351
Trichomonas vaginalis rotamase, putative 0.0033 0.0153 0.1086
Brugia malayi Inositol-1 0.0037 0.0175 0.1418
Schistosoma mansoni tyrosine kinase 0.0024 0.0095 0.0276
Echinococcus granulosus neuropeptide Y receptor 0.0031 0.0142 0.0351
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0071 0.0383 0.095
Onchocerca volvulus 0.0031 0.0142 0.1002
Schistosoma mansoni nAChR subunit 0.0019 0.0064 0.0185
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0034 0.2015
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.012 0.0685 0.7377
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.012 0.0685 0.7377
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0229 0.0229
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0135 0.4671
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0142 0.0351
Brugia malayi ORL1-like opioid receptor 0.0031 0.0142 0.1146
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0034 0.1161
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0064 0.0515
Echinococcus granulosus g protein coupled receptor 0.0031 0.0142 0.0351
Echinococcus multilocularis neuropeptide receptor 0.0031 0.0142 0.0142
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0001 0.0008
Echinococcus granulosus g protein coupled receptor 0.0031 0.0142 0.0351
Onchocerca volvulus 0.0019 0.0064 0.0451
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0282 0.0701
Schistosoma mansoni neurotransmitter gated ion channel 0.0009 0.0001 0.0003
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0034 0.0362
Echinococcus granulosus biogenic amine 5HT receptor 0.0031 0.0142 0.0351
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0064 0.0064
Brugia malayi Metabotropic glutamate receptor precursor. 0.0024 0.0095 0.0768
Schistosoma mansoni neuropeptide receptor 0.0031 0.0142 0.0412
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0229 0.057
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0031 0.0142 0.1146
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0012 0.0022 0.0233
Echinococcus granulosus tachykinin peptides receptor 99D 0.0031 0.0142 0.0351
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0142 0.0412
Brugia malayi Pre-SET motif family protein 0.0209 0.1235 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0009 0.0009
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0031 0.0142 0.0142
Schistosoma mansoni inositol monophosphatase 0.0037 0.0175 0.0509
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0142 0.0142
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0047 0.0235 0.0235
Loa Loa (eye worm) histone methyltransferase 0.001 0.0009 0.0072
Trichomonas vaginalis set domain proteins, putative 0.0237 0.1412 1
Echinococcus granulosus expressed protein 0.0033 0.0153 0.0381
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0515
Echinococcus multilocularis neuropeptides capa receptor 0.0031 0.0142 0.0142
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0031 0.0142 0.0351
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0064 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0135 0.0394
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0031 0.0142 0.1002
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0034 0.1161
Echinococcus multilocularis protein dispatched 1 0.0049 0.0248 0.0248
Brugia malayi mbt repeat family protein 0.0048 0.0242 0.1956
Loa Loa (eye worm) glutamate receptor 2 0.0047 0.0235 0.1904
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0142 0.0142
Schistosoma mansoni cpg binding protein 0.003 0.0135 0.0391
Echinococcus multilocularis neuropeptide receptor 0.0031 0.0142 0.0142
Schistosoma mansoni adenoreceptor 0.0031 0.0142 0.0412
Brugia malayi hypothetical protein 0.0031 0.0142 0.1146
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.012 0.0685 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0142 0.0142
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0063 0.035
Onchocerca volvulus 0.0031 0.0142 0.1002
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0019 0.0064 0.0515
Echinococcus multilocularis nmda type glutamate receptor 0.0662 0.4028 0.4028
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0019 0.0064 0.0515
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0064 0.0158
Loa Loa (eye worm) hypothetical protein 0.0024 0.0095 0.0768
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0031 0.0142 0.0142
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.001 0.001 0.0029
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.012 0.0685 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0064 0.0158
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0175 0.124
Loa Loa (eye worm) hypothetical protein 0.0043 0.0211 0.1705
Echinococcus multilocularis nAChR subunit 0.001 0.001 0.001
Brugia malayi Dopamine receptor 0.0031 0.0142 0.1146
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0142 0.0142
Schistosoma mansoni nAChR subunit 0.0019 0.0064 0.0185
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0063 0.3794
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0034 0.0362
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0031 0.0142 0.0412
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0071 0.0383 0.0383
Schistosoma mansoni neuropeptide receptor 0.0031 0.0142 0.0412
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0142 0.0142
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0241 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0282 0.2286
Brugia malayi putative neuropeptide receptor 0.0031 0.0142 0.1146
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0034 0.0272
Brugia malayi sulfakinin receptor protein 0.0031 0.0142 0.1146
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0063 0.0513
Loa Loa (eye worm) hypothetical protein 0.0031 0.0142 0.1146

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 5.2 mg kg-1 In vivo beta-adrenoceptor blocking potency measured by by blockade of the isoproterenol tachycardia response in rat ChEMBL. 6102152
ED50 (functional) ug kg-1 Beta-adrenoceptor blocking potency in cat as dose causing 50% inhibition of the tachycardia produced by 0.2 ug/kg iv of isoproterenol; ND means no data ChEMBL. 6102152

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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