Detailed information for compound 1532597

Basic information

Technical information
  • TDR Targets ID: 1532597
  • Name: N-[3-[(4-chlorophenyl)sulfamoyl]-4-morpholin- 4-ylphenyl]propanamide
  • MW: 423.914 | Formula: C19H22ClN3O4S
  • H donors: 2 H acceptors: 3 LogP: 2.47 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)Nc1ccc(c(c1)S(=O)(=O)Nc1ccc(cc1)Cl)N1CCOCC1
  • InChi: 1S/C19H22ClN3O4S/c1-2-19(24)21-16-7-8-17(23-9-11-27-12-10-23)18(13-16)28(25,26)22-15-5-3-14(20)4-6-15/h3-8,13,22H,2,9-12H2,1H3,(H,21,24)
  • InChiKey: OXKYYGJNRBCCBB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-[(4-chlorophenyl)sulfamoyl]-4-morpholino-phenyl]propanamide
  • N-[3-[(4-chlorophenyl)sulfamoyl]-4-morpholinophenyl]propanamide
  • N-[3-[(4-chlorophenyl)sulfamoyl]-4-morpholino-phenyl]propionamide
  • N-[3-[(4-chlorophenyl)sulfamoyl]-4-morpholin-4-yl-phenyl]propanamide
  • T0509-9033

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens regulator of G-protein signaling 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0619 0.3458
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0251 0.075
Echinococcus multilocularis beta adrenergic receptor kinase 0.0024 0.0053 0.0009
Brugia malayi Heterochromatin protein 1 0.0084 0.0432 0.2906
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0066 0.0058
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0619 0.3458
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0051 0.0004
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0253 0.1486 0.2526
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0114 0.039
Plasmodium vivax hypothetical protein, conserved 0.0253 0.1486 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0066 0.0071
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0619 0.2608
Echinococcus granulosus importin subunit beta 1 0.0035 0.0123 0.0273
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0251 0.075
Leishmania major hypothetical protein, conserved 0.0253 0.1486 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.0619 0.3095
Brugia malayi PXA domain containing protein 0.0023 0.005 0.0339
Mycobacterium tuberculosis Conserved protein 0.0253 0.1486 0.1442
Brugia malayi hypothetical protein 0.0023 0.005 0.0339
Loa Loa (eye worm) hypothetical protein 0.0253 0.1486 0.6585
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0051 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0259 0.1267
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0251 0.075
Mycobacterium ulcerans lipoprotein LpqF 0.0447 0.2701 0.4667
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0253 0.1486 0.1442
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0051 0.0168
Leishmania major importin beta-1 subunit, putative 0.0028 0.0082 0.0215
Onchocerca volvulus 0.005 0.0217 0.0516
Trypanosoma cruzi hypothetical protein, conserved 0.0253 0.1486 1
Brugia malayi Importin beta-1 subunit 0.0035 0.0123 0.083
Loa Loa (eye worm) hypothetical protein 0.0253 0.1486 0.6585
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0051 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0251 0.0921
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0051 0.0017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0253 0.1486 0.6585
Brugia malayi PXA domain containing protein 0.0023 0.005 0.0339
Mycobacterium ulcerans hypothetical protein 0.0253 0.1486 0.2526
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0082 0.0215
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0051 0.0168
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.0619 0.2126
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.0619 0.2608
Loa Loa (eye worm) hypothetical protein 0.0035 0.0123 0.0335
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0131 0.037
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.0619 0.2126
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0123 0.0271
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0251 0.169
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0051 0.0004
Echinococcus multilocularis chromobox protein 1 0.0084 0.0432 0.1426
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0051 0.0168
Schistosoma mansoni ran 0.0026 0.0066 0.0071
Loa Loa (eye worm) hypothetical protein 0.0253 0.1486 0.6585
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0619 0.3957
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0051 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0051 0.0168
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.005 0.0339
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0082 0.0193
Mycobacterium tuberculosis Probable lipase LipE 0.0253 0.1486 0.1442
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0223 0.105
Entamoeba histolytica hypothetical protein 0.0028 0.0082 0.0559
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0051 0.0345
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.005 0.0339
Echinococcus granulosus dna polymerase eta 0.0023 0.0051 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0051 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0619 0.3458
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0051 0.0006
Schistosoma mansoni chromobox protein 0.0084 0.0432 0.175
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0432 0.175
Schistosoma mansoni hypothetical protein 0.0372 0.223 1
Mycobacterium tuberculosis Probable hydrolase 0.0253 0.1486 0.1442
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0223 0.105
Trichomonas vaginalis esterase, putative 0.0253 0.1486 0.8731
Brugia malayi hypothetical protein 0.0023 0.005 0.0339
Schistosoma mansoni chromobox protein 0.0084 0.0432 0.175
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1694 1
Brugia malayi beta-lactamase family protein 0.0253 0.1486 1
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0259 0.1267
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0131 0.037
Echinococcus granulosus dna polymerase kappa 0.0023 0.0051 0.0004
Onchocerca volvulus 0.0286 0.1694 1
Brugia malayi Pre-SET motif family protein 0.0036 0.0131 0.0882
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0051 0.0168
Echinococcus granulosus beta-adrenergic receptor kinase 0.0024 0.0053 0.0009
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0253 0.1486 0.1442
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0432 0.232
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.005 0.0217 0.0765
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0619 0.3458
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0066 0.0101
Loa Loa (eye worm) hypothetical protein 0.0036 0.0131 0.037
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0082 0.0193
Loa Loa (eye worm) hypothetical protein 0.0253 0.1486 0.6585
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0223 0.0553
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0619 0.3458
Mycobacterium ulcerans beta-lactamase 0.0253 0.1486 0.2526
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0619 0.3458
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0053 0.0011
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0082 0.0193
Trichomonas vaginalis D-aminoacylase, putative 0.0253 0.1486 0.8731
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0201 0.0913
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0051 0.0168
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0051 0.0004
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0123 0.0273
Echinococcus multilocularis snurportin 1 0.0372 0.223 0.8152
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0251 0.0921
Entamoeba histolytica Ran family GTPase 0.0026 0.0066 0.0273
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0131 0.0302
Plasmodium falciparum importin beta, putative 0.0035 0.0123 1
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.005 0.0339
Echinococcus granulosus snurportin 1 0.0372 0.223 0.8152
Trichomonas vaginalis penicillin-binding protein, putative 0.0253 0.1486 0.8731
Loa Loa (eye worm) hypothetical protein 0.0253 0.1486 0.6585
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0053 0.0011
Echinococcus granulosus chromobox protein 1 0.0084 0.0432 0.1426
Schistosoma mansoni ran 0.0026 0.0066 0.0071
Mycobacterium ulcerans esterase/lipase LipP 0.0253 0.1486 0.2526
Mycobacterium tuberculosis Probable lipase LipD 0.0253 0.1486 0.1442
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.0619 0.3957
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0123 0.0435
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.005 0.0339
Loa Loa (eye worm) hypothetical protein 0.0047 0.0201 0.0689
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0051 0.0168
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0131 0.037
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0051 0.0168
Mycobacterium tuberculosis Conserved protein 0.0253 0.1486 0.1442
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0024 0.0053 0.0355
Trichomonas vaginalis ran, putative 0.0026 0.0066 0.0094
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0253 0.1486 1
Schistosoma mansoni DNA polymerase eta 0.0023 0.0051 0.0004
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0432 0.232
Echinococcus multilocularis dna polymerase eta 0.0023 0.0051 0.0004
Trypanosoma brucei unspecified product 0.0023 0.0051 0.0168
Loa Loa (eye worm) hypothetical protein 0.0037 0.0137 0.0397
Plasmodium vivax importin-beta 2, putative 0.0035 0.0123 0.0405
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0251 0.075
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.223 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0253 0.1486 0.5368
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0024 0.0053 0.0011
Trypanosoma brucei beta lactamase 0.0447 0.2701 1
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0931 0.5729 0.5707
Echinococcus granulosus expressed protein 0.0451 0.2724 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0024 0.0053 0.0011
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1477 0.6546
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0051 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0004
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0201 0.0409
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0066 0.0256
Trypanosoma cruzi hypothetical protein, conserved 0.0253 0.1486 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0066 0.0101
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0051 0.0168
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0253 0.1486 0.6585
Brugia malayi RNA, U transporter 1 0.0099 0.0525 0.3532
Echinococcus multilocularis expressed protein 0.0451 0.2724 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0253 0.1486 0.8731
Echinococcus multilocularis chromobox protein 1 0.0084 0.0432 0.1426
Loa Loa (eye worm) hypothetical protein 0.0253 0.1486 0.6585
Onchocerca volvulus 0.0253 0.1486 0.866
Toxoplasma gondii ABC1 family protein 0.0253 0.1486 1
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0447 0.2701 1
Onchocerca volvulus 0.0253 0.1486 0.866
Echinococcus granulosus chromobox protein 1 0.0084 0.0432 0.1426
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.005 0.0339
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0251 0.0921
Echinococcus granulosus geminin 0.0205 0.1185 0.4244
Trypanosoma brucei hypothetical protein, conserved 0.0253 0.1486 0.549
Schistosoma mansoni kinase 0.0058 0.0268 0.0999
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.0619 1
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0051 0.0345
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0051 0.0168
Brugia malayi chromobox protein homolog 3 0.0047 0.0201 0.135
Trichomonas vaginalis D-aminoacylase, putative 0.0253 0.1486 0.8731
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0201 0.0913
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0051 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0619 0.3458
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0251 0.0921
Plasmodium vivax SET domain protein, putative 0.0036 0.0131 0.0459
Loa Loa (eye worm) beta-lactamase 0.0253 0.1486 0.6585
Giardia lamblia Kinase, PLK 0.0114 0.0619 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.0619 0.4166
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0131 0.0302
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0066 0.0222
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0051 0.0004
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0123 0.0435
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0131 0.0459
Echinococcus multilocularis geminin 0.0205 0.1185 0.4244
Brugia malayi Pre-SET motif family protein 0.0251 0.1477 0.9943
Schistosoma mansoni hypothetical protein 0.0205 0.1185 0.5206
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0253 0.1486 0.1442
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0123 0.0405
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0131 0.0302
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0447 0.2701 0.2663
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0066 0.0443
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0051 0.0168
Schistosoma mansoni importin beta-1 0.0035 0.0123 0.0335
Onchocerca volvulus 0.0253 0.1486 0.866
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0066 0.0058
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0931 0.5729 1
Trichomonas vaginalis D-aminoacylase, putative 0.0253 0.1486 0.8731
Trypanosoma brucei polo-like protein kinase 0.0114 0.0619 0.2274
Mycobacterium tuberculosis Conserved protein 0.0253 0.1486 0.1442
Brugia malayi beta-lactamase family protein 0.0253 0.1486 1
Mycobacterium ulcerans lipase LipD 0.0253 0.1486 0.2526
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0114 0.039
Schistosoma mansoni hypothetical protein 0.0205 0.1185 0.5206
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0619 0.3957
Echinococcus multilocularis beta LACTamase domain containing family member 0.0253 0.1486 0.5368
Brugia malayi beta-lactamase 0.0253 0.1486 1
Mycobacterium tuberculosis Probable esterase LipL 0.0253 0.1486 0.1442
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0053 0.0011
Leishmania major GTP-binding protein, putative 0.0026 0.0066 0.0101
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0253 0.1486 0.6585

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1032 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.122 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.5193 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 30.1313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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