Detailed information for compound 1537286

Basic information

Technical information
  • TDR Targets ID: 1537286
  • Name: 2-(2-acetylbenzimidazol-1-yl)-1-(4-methoxyphe nyl)ethanone
  • MW: 308.331 | Formula: C18H16N2O3
  • H donors: 0 H acceptors: 3 LogP: 2.94 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=O)Cn1c(nc2c1cccc2)C(=O)C
  • InChi: 1S/C18H16N2O3/c1-12(21)18-19-15-5-3-4-6-16(15)20(18)11-17(22)13-7-9-14(23-2)10-8-13/h3-10H,11H2,1-2H3
  • InChiKey: SGPGEGNAZBZTRE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-acetyl-1-benzimidazolyl)-1-(4-methoxyphenyl)ethanone
  • 2-(2-ethanoylbenzimidazol-1-yl)-1-(4-methoxyphenyl)ethanone
  • AIDS-146645
  • AIDS146645
  • Ethanone, 2-(2-acetyl-1H-benzimidazol-1-yl)-1-(4-methoxyphenyl)-
  • NSC674258
  • NCI60_026324

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0379 0.1429
Echinococcus multilocularis neuropeptide s receptor 0.0451 0.5054 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0203 0.0579
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0064 0.0599 0.0597
Plasmodium falciparum mitogen-activated protein kinase 2 0.0336 0.3725 0.3724
Loa Loa (eye worm) hypothetical protein 0.0049 0.0427 0.1221
Echinococcus multilocularis solute carrier family 22 0.0029 0.0203 0.0402
Loa Loa (eye worm) hypothetical protein 0.0035 0.027 0.0772
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Brugia malayi Cam kinase protein 1 0.0064 0.0598 0.2258
Onchocerca volvulus 0.0029 0.0203 0.4632
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.0203 0.0825
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0203 0.0762
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.027 0.3834
Brugia malayi hypothetical protein 0.0029 0.0203 0.0762
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0702 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0116 0.0115
Schistosoma mansoni sugar transporter 0.0029 0.0203 0.0583
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0203 0.0642
Schistosoma mansoni DNA ligase IV 0.0012 0.0004 0.0011
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0062 0.0583 0.1855
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0004 0.0033
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0142 0.0447
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0004 0.0007
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Plasmodium vivax sugar transporter, putative 0.0029 0.0203 0.0201
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0064 0.0598 0.2258
Giardia lamblia Hexose transporter 0.0029 0.0203 0.0642
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0203 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0702 1
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0004 0.0008
Onchocerca volvulus 0.0029 0.0203 0.4632
Entamoeba histolytica hypothetical protein 0.0024 0.0142 0.0447
Onchocerca volvulus 0.0029 0.0203 0.4632
Brugia malayi Importin beta-1 subunit 0.0029 0.0206 0.0773
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0702 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.04 0.1149
Brugia malayi topoisomerase 0.0012 0.0004 0.0009
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0608 0.8651
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0228 0.0855
Echinococcus granulosus General substrate transporter 0.0179 0.1919 0.3797
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.027 0.0856
Echinococcus granulosus neuropeptide s receptor 0.0451 0.5054 1
Schistosoma mansoni survival motor neuron protein 0.0049 0.0434 0.1245
Brugia malayi Sugar transporter family protein 0.0029 0.0203 0.0762
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.04 0.1149
Leishmania major hypothetical protein, conserved 0.0026 0.0163 0.2308
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0228 0.045
Plasmodium vivax hexose transporter 0.0208 0.2255 0.2253
Toxoplasma gondii sugar transporter ST3 0.0029 0.0203 0.0305
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0004 0.0003
Echinococcus granulosus peregrin 0.0028 0.0194 0.0383
Trypanosoma cruzi hexose transporter 0.0064 0.0608 0.8651
Schistosoma mansoni glucose transport protein 0.0208 0.2255 0.6476
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.1465 1
Schistosoma mansoni sugar transporter 0.0029 0.0203 0.0583
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.027 0.0535
Echinococcus granulosus solute carrier family 22 0.0029 0.0203 0.0402
Echinococcus granulosus GPCR family 2 0.0031 0.0228 0.045
Leishmania major GTP-binding protein, putative 0.0022 0.0116 0.164
Brugia malayi beta-lactamase family protein 0.0035 0.027 0.1017
Trichomonas vaginalis ran, putative 0.0022 0.0116 0.0366
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0064 0.0598 0.1184
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Mycobacterium leprae conserved hypothetical protein 0.0035 0.027 0.1835
Schistosoma mansoni hypothetical protein 0.0028 0.0194 0.0556
Echinococcus multilocularis snurportin 1 0.0315 0.3482 0.6889
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0203 0.0642
Plasmodium vivax lysine--tRNA ligase, putative 0.0046 0.04 0.0399
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Plasmodium vivax CDK-related protein kinase 6, putative 0.0882 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.027 0.0772
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3138 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0702 1
Onchocerca volvulus 0.0029 0.0203 0.4632
Echinococcus granulosus solute carrier family 22 0.0029 0.0203 0.0402
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0046 0.04 0.2723
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.3138 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0203 0.0579
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0004 0.0009
Toxoplasma gondii ABC1 family protein 0.0035 0.027 0.0406
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.027 0.1017
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.027 0.1101
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0206 0.0309
Onchocerca volvulus 0.0029 0.0203 0.4632
Schistosoma mansoni hypothetical protein 0.0049 0.0434 0.1245
Loa Loa (eye worm) hypothetical protein 0.0026 0.0163 0.0465
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0019 0.008 0.025
Loa Loa (eye worm) hypothetical protein 0.0062 0.0583 0.1672
Schistosoma mansoni ran 0.0022 0.0116 0.0334
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0379 0.1089
Chlamydia trachomatis lysine--tRNA ligase 0.0046 0.04 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0206 0.2916
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.027 0.1101
Leishmania major hypothetical protein, conserved 0.0029 0.0203 0.2874
Loa Loa (eye worm) hypothetical protein 0.0028 0.0194 0.0552
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0163 0.2308
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0163 0.0245
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0064 0.0599 0.0597
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.027 0.1101
Trypanosoma brucei glucose transporter, putative 0.0064 0.0608 0.8651
Echinococcus multilocularis lysyl tRNA synthetase 0.0046 0.04 0.0792
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0206 0.0407
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0936 0.1852
Mycobacterium tuberculosis Conserved protein 0.0035 0.027 0.1101
Chlamydia trachomatis glutamine binding protein 0.0019 0.008 0.197
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0046 0.04 0.1271
Entamoeba histolytica hypothetical protein 0.0046 0.04 0.1271
Brugia malayi Sugar transporter family protein 0.0208 0.2255 0.8527
Brugia malayi hypothetical protein 0.0029 0.0203 0.0762
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0379 0.075
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0062 0.0583 0.1676
Echinococcus granulosus jumonji domain containing protein 0.004 0.0321 0.0636
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0203 0.0579
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.027 0.0856
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0608 0.8651
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0142 0.0447
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0116 0.0435
Echinococcus granulosus nmda type glutamate receptor 0.0026 0.0163 0.0323
Onchocerca volvulus 0.0029 0.0203 0.4632
Mycobacterium tuberculosis Conserved protein 0.0035 0.027 0.1101
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0203 0.1376
Brugia malayi jmjC domain containing protein 0.0093 0.0936 0.3536
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0208 0.2255 0.4461
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0336 0.3725 0.5632
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3138 1
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0019 0.008 0.197
Echinococcus multilocularis solute carrier family 22 0.0029 0.0203 0.0402
Plasmodium vivax importin-beta 2, putative 0.0029 0.0206 0.0204
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.012 0.0811
Loa Loa (eye worm) sugar transporter 0.0208 0.2255 0.6474
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0203 0.2874
Loa Loa (eye worm) hypothetical protein 0.0035 0.027 0.0772
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Schistosoma mansoni hypothetical protein 0.0031 0.0228 0.0654
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0379 0.1085
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0163 0.0162
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0203 0.0402
Echinococcus granulosus snurportin 1 0.0315 0.3482 0.6889
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0262 0.0753
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0262 0.0519
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Plasmodium falciparum importin beta, putative 0.0029 0.0206 0.0204
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1006 0.3801
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0598 0.1718
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Giardia lamblia Fructose-bisphosphate aldolase 0.0285 0.3138 1
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0608 0.8651
Loa Loa (eye worm) hypothetical protein 0.0035 0.027 0.0772
Leishmania major glucose transporter, lmgt2 0.0064 0.0608 0.8651
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0203 0.0642
Loa Loa (eye worm) hypothetical protein 0.0062 0.0583 0.1672
Echinococcus multilocularis peregrin 0.0028 0.0194 0.0383
Loa Loa (eye worm) hypothetical protein 0.0029 0.0203 0.0579
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0936 0.1852
Schistosoma mansoni hypothetical protein 0.0315 0.3482 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0228 0.045
Trypanosoma brucei glucose transporter, putative 0.0064 0.0608 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0194 0.0556
Plasmodium falciparum lysine--tRNA ligase 0.0046 0.04 0.0399
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0203 0.0583
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0203 0.0762
Schistosoma mansoni protein kinase 0.0064 0.0598 0.1718
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0598 0.1184
Treponema pallidum fructose-bisphosphate aldolase 0.0285 0.3138 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3138 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Trypanosoma brucei glucose transporter, putative 0.0064 0.0608 0.8651
Brugia malayi PHD-finger family protein 0.0028 0.0194 0.0726
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0206 0.2916
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.0004 0.0002
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.04 0.2723
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Toxoplasma gondii sugar transporter ST2 0.0029 0.0203 0.0305
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.027 0.1101
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0064 0.0599 0.0903
Loa Loa (eye worm) hypothetical protein 0.0068 0.0646 0.1851
Plasmodium falciparum calcium-dependent protein kinase 3 0.0064 0.0599 0.0597
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0228 0.045
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.027 0.1101
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0004 0.0007
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Trypanosoma brucei sugar transporter, putative 0.0029 0.0203 0.2874
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0203 0.0762
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.1465 0.5998
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.027 0.0535
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0004 0.0007
Onchocerca volvulus 0.0029 0.0203 0.4632
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0142 0.2002
Leishmania major glucose transporter/membrane transporter D2, putative 0.0064 0.0608 0.8651
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0272 0.386
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0379 0.075
Loa Loa (eye worm) hypothetical protein 0.0029 0.0203 0.0579
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0598 0.1184
Echinococcus multilocularis geminin 0.0173 0.1857 0.3674
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0208 0.2255 0.4461
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0019 0.008 0.0536
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0062 0.0583 0.2202
Leishmania major glucose transporter, lmgt3 0.0064 0.0608 0.8651
Onchocerca volvulus 0.0035 0.027 0.6197
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0228 0.0649
Brugia malayi jmjC domain containing protein 0.0034 0.0262 0.0986
Leishmania major glucose transporter, lmgt1 0.0064 0.0608 0.8651
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0004 0.0007
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0019 0.008 0.0322
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0194 0.0383
Echinococcus multilocularis solute carrier family 22 0.0029 0.0203 0.0402
Mycobacterium tuberculosis Conserved protein 0.0035 0.027 0.1101
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0004 0.0033
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0064 0.0599 0.0903
Trypanosoma brucei glucose transporter, putative 0.0064 0.0608 0.8651
Entamoeba histolytica protein kinase, putative 0.0064 0.0598 0.1902
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0064 0.0598 0.1715
Brugia malayi hypothetical protein 0.0026 0.0163 0.0612
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0203 0.0642
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0161 0.0459
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0203 0.0579
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Plasmodium falciparum calcium-dependent protein kinase 5 0.0064 0.0599 0.0597
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0203 0.0642
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0004 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0598 0.1902
Entamoeba histolytica protein kinase, putative 0.0064 0.0598 0.1902
Mycobacterium ulcerans hypothetical protein 0.0035 0.027 0.1835
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Trypanosoma brucei glucose transporter 2A 0.0064 0.0608 0.8651
Schistosoma mansoni ran 0.0022 0.0116 0.0334
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0194 0.0383
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0379 0.075
Trichomonas vaginalis esterase, putative 0.0035 0.027 0.0856
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0062 0.0583 0.1676
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0062 0.0583 0.3976
Loa Loa (eye worm) hypothetical protein 0.0029 0.0203 0.0579
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0608 0.8651
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0194 0.029
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0004 0.0033
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0163 0.0162
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0012 0.0004 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0203 0.0642
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2255 0.4461
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0194 0.029
Loa Loa (eye worm) hypothetical protein 0.0029 0.0203 0.0579
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Brugia malayi hypothetical protein 0.0242 0.2644 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0702 1
Brugia malayi lysyl-tRNA synthetase 0.0046 0.04 0.1508
Onchocerca volvulus 0.0029 0.0203 0.4632
Giardia lamblia Prolyl-tRNA synthetase 0.0062 0.0583 0.1855
Brugia malayi hypothetical protein 0.0012 0.0004 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3138 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0608 0.8651
Onchocerca volvulus Alhambra homolog 0.0028 0.0194 0.4413
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0116 0.164
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0062 0.0583 0.1154
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0203 0.2874
Onchocerca volvulus 0.0035 0.027 0.6197
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0062 0.0583 0.1855
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3138 1
Onchocerca volvulus 0.0029 0.0203 0.4632
Loa Loa (eye worm) hypothetical protein 0.0029 0.0203 0.0579
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0004 0.0003
Treponema pallidum DNA ligase (lig) 0.0012 0.0004 0.0007
Leishmania major lysyl-tRNA synthetase, putative 0.0046 0.04 0.5689
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0262 0.0749
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0026 0.0163 0.0323
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0379 0.1089
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0116 0.0366
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.2255 0.7183
Schistosoma mansoni topbp1 0.0012 0.0004 0.0011
Plasmodium falciparum protein kinase 7 0.0587 0.6612 0.6612
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0062 0.0583 0.1154
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0203 0.0642
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3138 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.027 0.0856
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0019 0.008 0.025
Giardia lamblia Replication factor C, subunit 1 0.0012 0.0004 0.0007
Schistosoma mansoni glucose transporter 0.0029 0.0203 0.0583
Trypanosoma brucei glucose transporter, putative 0.0064 0.0608 0.8651
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2255 0.4461
Schistosoma mansoni importin beta-1 0.0029 0.0206 0.0591
Brugia malayi hypothetical protein 0.0012 0.0004 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.027 0.3834
Onchocerca volvulus 0.0029 0.0203 0.4632
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0608 0.1932
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Onchocerca volvulus 0.0029 0.0203 0.4632
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.0203 0.0825
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0064 0.0598 0.1715
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.0002 0.0003
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0608 0.1932
Entamoeba histolytica hypothetical protein 0.0012 0.0004 0.0007
Schistosoma mansoni hypothetical protein 0.0208 0.2255 0.6476
Brugia malayi hypothetical protein 0.0029 0.0203 0.0762
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0315 0.3482 1
Onchocerca volvulus 0.0029 0.0203 0.4632
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.027 0.0856
Brugia malayi hypothetical protein 0.0017 0.0058 0.0215
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0608 0.1932
Schistosoma mansoni topbp1 0.0012 0.0004 0.0011
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.0002 0.0003
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.027 0.0772
Loa Loa (eye worm) hypothetical protein 0.0035 0.027 0.0772
Loa Loa (eye worm) hypothetical protein 0.0242 0.2644 0.7593
Onchocerca volvulus 0.0035 0.027 0.6197
Chlamydia trachomatis DNA ligase 0.0012 0.0004 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0203 0.0642
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1524 0.4375
Echinococcus granulosus lysyl tRNA synthetase 0.0046 0.04 0.0792
Loa Loa (eye worm) sugar transporter 0.0029 0.0203 0.0579
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0203 0.1376
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0064 0.0599 0.0597
Schistosoma mansoni hypothetical protein 0.0068 0.0646 0.1855
Brugia malayi Sugar transporter family protein 0.0029 0.0203 0.0762
Brugia malayi MH2 domain containing protein 0.0144 0.1524 0.5762
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.027 0.1835
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Loa Loa (eye worm) hypothetical protein 0.0029 0.0203 0.0579
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0203 0.2874
Schistosoma mansoni sugar transporter 0.0029 0.0203 0.0583
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0541 0.155
Brugia malayi beta-lactamase family protein 0.0035 0.027 0.1017
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.012 0.2978
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0203 0.2874
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Leishmania major hypothetical protein, conserved 0.0035 0.027 0.3834
Echinococcus multilocularis neuropeptide receptor A26 0.0451 0.5054 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0116 0.0115
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0598 0.1184
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.027 0.0776
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.2644 0.5231
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Plasmodium vivax calcium-dependent protein kinase, putative 0.0064 0.0599 0.0597
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0321 0.0636
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.2644 0.5231
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0598 0.1184
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.0004 0.0002
Trichomonas vaginalis glucose transporter, putative 0.0064 0.0608 0.1932
Trypanosoma brucei glucose transporter, putative 0.0064 0.0608 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Loa Loa (eye worm) hypothetical protein 0.0029 0.0203 0.0579
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0064 0.0599 0.0903
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0608 0.1932
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0163 0.2308
Leishmania major protein kinase, putative 0.0064 0.0598 0.8517
Echinococcus multilocularis nmda type glutamate receptor 0.0026 0.0163 0.0323
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0004 0.0007
Brugia malayi Bromodomain containing protein 0.0028 0.0194 0.0726
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.032 0.1304
Loa Loa (eye worm) hypothetical protein 0.0029 0.0206 0.0587
Echinococcus multilocularis General substrate transporter 0.0179 0.1919 0.3797
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.1465 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.032 0.2175
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0598 0.1184
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0203 0.0305
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0116 0.033
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0203 0.0201
Echinococcus granulosus importin subunit beta 1 0.0029 0.0206 0.0407
Toxoplasma gondii protein kinase, putative 0.0587 0.6612 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0336 0.3725 0.3724
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0208 0.2255 0.4461
Echinococcus granulosus geminin 0.0173 0.1857 0.3674
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0116 0.164
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0208 0.2255 0.4461
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.027 0.1101
Loa Loa (eye worm) hypothetical protein 0.0029 0.0203 0.0579
Schistosoma mansoni hypothetical protein 0.0031 0.0228 0.0654
Schistosoma mansoni glucose transport protein 0.0208 0.2255 0.6476
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0334 0.1061
Echinococcus multilocularis GPCR, family 2 0.0031 0.0228 0.045
Echinococcus granulosus solute carrier family 22 0.0029 0.0203 0.0402
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0608 0.8651
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0004 0.0007
Onchocerca volvulus Putative transporter 0.0029 0.0203 0.4632
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1006 0.2886
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.0004 0.0033
Schistosoma mansoni protein kinase 0.0064 0.0598 0.1718
Echinococcus granulosus calcium dependent protein kinase 0.006 0.0553 0.1094
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0163 0.0162
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0598 0.1184
Echinococcus granulosus nibrin 0.0012 0.0004 0.0008
Brugia malayi RNA, U transporter 1 0.0084 0.083 0.3136
Mycobacterium ulcerans beta-lactamase 0.0035 0.027 0.1835
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0379 0.1089
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0194 0.0552
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0004 0.0033
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.0002 0.0003
Echinococcus multilocularis calcium dependent protein kinase 0.006 0.0553 0.1094
Mycobacterium ulcerans lipase LipD 0.0035 0.027 0.1835
Plasmodium falciparum proline--tRNA ligase 0.0073 0.0702 0.0701
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0004 0.0009
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.027 0.1101
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.0002 0.0004
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.012 0.0378
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0194 0.0192
Plasmodium vivax proline--tRNA ligase, putative 0.0073 0.0702 0.0701
Brugia malayi DKFZp564C0469 protein 0.0012 0.0004 0.0009
Echinococcus granulosus neuropeptide receptor A26 0.0451 0.5054 1
Schistosoma mansoni glucose transport protein 0.0208 0.2255 0.6476
Echinococcus granulosus solute carrier family 22 0.0029 0.0203 0.0402
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0004 0.0007
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0203 0.0402
Mycobacterium leprae Probable lipase LipE 0.0035 0.027 0.1835
Onchocerca volvulus 0.0029 0.0203 0.4632
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0046 0.04 0.5689
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.027 0.0856
Giardia lamblia PHD finger protein 15 0.0028 0.0194 0.0612
Onchocerca volvulus 0.0029 0.0203 0.4632
Loa Loa (eye worm) hypothetical protein 0.0051 0.0449 0.1286
Plasmodium falciparum hexose transporter 0.0208 0.2255 0.2253
Trypanosoma brucei glucose transporter, putative 0.0064 0.0608 0.8651
Onchocerca volvulus 0.0029 0.0203 0.4632
Loa Loa (eye worm) hypothetical protein 0.0029 0.0203 0.0579
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0203 0.0402
Trypanosoma brucei glucose transporter, putative 0.0064 0.0608 0.8651
Toxoplasma gondii sugar transporter ST1 0.0029 0.0203 0.0305
Loa Loa (eye worm) hypothetical protein 0.0029 0.0203 0.0579
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0716 0.2057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3138 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0064 0.0598 0.8517
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0142 0.0447
Schistosoma mansoni sugar transporter 0.0029 0.0203 0.0583
Plasmodium vivax hypothetical protein, conserved 0.0035 0.027 0.0269
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2255 0.4461
Leishmania major importin beta-1 subunit, putative 0.0024 0.0142 0.2002
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0203 0.0402
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0116 0.164
Plasmodium falciparum calcium-dependent protein kinase 2 0.0064 0.0599 0.0597
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1006 0.3801
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.2442 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0064 0.0599 0.0597
Brugia malayi major facilitator superfamily protein 0.0029 0.0203 0.0762
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0608 0.1932
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.2255 0.4461
Loa Loa (eye worm) hypothetical protein 0.0029 0.0203 0.0579
Plasmodium falciparum calcium-dependent protein kinase 4 0.0064 0.0599 0.0597
Mycobacterium ulcerans sugar transporter 0.0029 0.0203 0.1376
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0116 0.023
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0012 0.0004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0064 0.0598 0.1715
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0073 0.0702 0.106
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0598 0.1184
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.027 0.0776
Loa Loa (eye worm) hypothetical protein 0.0029 0.0203 0.0579
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0262 0.0753
Toxoplasma gondii facilitative glucose transporter GT1 0.0208 0.2255 0.3408
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0379 0.075
Schistosoma mansoni hypothetical protein 0.0173 0.1857 0.5333
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0203 0.2874
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.3138 1
Giardia lamblia Sugar-proton symporter 0.0029 0.0203 0.0642
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0434 0.1635
Giardia lamblia Lysyl-tRNA synthetase 0.0046 0.04 0.1271
Loa Loa (eye worm) hypothetical protein 0.0031 0.0228 0.0649
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.027 0.1835
Trichomonas vaginalis glucose transporter, putative 0.0064 0.0608 0.1932
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0116 0.023
Schistosoma mansoni hypothetical protein 0.0031 0.0228 0.0654
Schistosoma mansoni hypothetical protein 0.0173 0.1857 0.5333
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0012 0.0004 0.0115
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0004 0.0008
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Toxoplasma gondii lysine-tRNA ligase 0.0046 0.04 0.0603
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0004 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.027 0.3834
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0116 0.0174
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1524 0.4375
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.04 0.2723
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0262 0.0519
Loa Loa (eye worm) beta-lactamase 0.0035 0.027 0.0772
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0203 0.1376
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0163 0.2308
Loa Loa (eye worm) hypothetical protein 0.0029 0.0203 0.0579
Brugia malayi major facilitator superfamily protein 0.0029 0.0203 0.0762
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Entamoeba histolytica Ran family GTPase 0.0022 0.0116 0.0366
Schistosoma mansoni protein kinase 0.0064 0.0598 0.1718
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0046 0.04 0.5689
Loa Loa (eye worm) hypothetical protein 0.0012 0.0004 0.0007
Plasmodium falciparum phd finger protein, putative 0.0028 0.0194 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0004 0.0007
Echinococcus multilocularis solute carrier family 22 0.0029 0.0203 0.0402
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0203 0.0642
Onchocerca volvulus 0.0049 0.0434 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.3138 1
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0646 0.2438
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0004 0.0011
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.0002 0.0003
Brugia malayi beta-lactamase 0.0035 0.027 0.1017
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0004 0.0007
Trypanosoma brucei glucose transporter 1E 0.0064 0.0608 0.8651
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0228 0.045
Echinococcus multilocularis nibrin 0.0012 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0035 0.027 0.0772
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0039 0.032 0.1304
Schistosoma mansoni hypothetical protein 0.0031 0.0228 0.0654
Loa Loa (eye worm) hypothetical protein 0.0046 0.04 0.1145
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0228 0.0855
Loa Loa (eye worm) hypothetical protein 0.0099 0.1006 0.2886
Onchocerca volvulus 0.0029 0.0203 0.4632
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0062 0.0583 0.2202

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.467 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.382 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.066 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.971 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.927 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.896 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.879 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.785 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.513 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.387 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.272 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 33.5875 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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