Detailed information for compound 154265

Basic information

Technical information
  • TDR Targets ID: 154265
  • Name: 1,11-dichloro-5-methyl-10H-indolo[3,2-b]quino lin-5-ium chloride
  • MW: 337.631 | Formula: C16H11Cl3N2
  • H donors: 1 H acceptors: 0 LogP: 5.56 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[n+]1c2cccc(c2c(c2c1c1ccccc1[nH]2)Cl)Cl.[Cl-]
  • InChi: 1S/C16H10Cl2N2.ClH/c1-20-12-8-4-6-10(17)13(12)14(18)15-16(20)9-5-2-3-7-11(9)19-15;/h2-8H,1H3;1H
  • InChiKey: NACOMPHJAUNVEH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,11-dichloro-5-methyl-10H-quinolino[3,2-b]indol-5-ium chloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0057 0.6216
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.003 0.0039 0.0039
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0039 0.0039
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0265 0.7868
Echinococcus granulosus BC026374 protein S09 family 0.0045 0.0091 0.0118
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0057 0.6216
Schistosoma mansoni transcription factor LCR-F1 0.0117 0.0337 0.0454
Schistosoma mansoni hypothetical protein 0.0035 0.0057 0.0076
Trichomonas vaginalis antibiotic synthetase, putative 0.003 0.0039 0.4181
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0117 0.0337 0.0373
Schistosoma mansoni hypothetical protein 0.004 0.0074 0.0099
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.003 0.0039 0.0036
Echinococcus granulosus tar DNA binding protein 0.0069 0.0175 0.0231
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0265 0.306
Echinococcus granulosus geminin 0.0165 0.0501 0.0671
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0043 0.0465
Loa Loa (eye worm) hypothetical protein 0.0045 0.0091 0.1022
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.003 0.0039 0.0036
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0038 0.0069 0.0073
Mycobacterium ulcerans acyl-CoA synthetase 0.0101 0.0282 0.0282
Echinococcus granulosus neuropeptide s receptor 0.0507 0.1665 0.2242
Treponema pallidum licC protein (licC) 0.0541 0.1783 0.5
Leishmania major 4-coumarate:coa ligase-like protein 0.0101 0.0282 0.2919
Brugia malayi Carboxylesterase family protein 0.0045 0.0091 0.1022
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.003 0.0039 0.1158
Schistosoma mansoni microtubule-associated protein tau 0.1444 0.486 0.6555
Loa Loa (eye worm) acetylcholinesterase 1 0.0265 0.0841 0.9798
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.003 0.0039 0.0036
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0265 0.0841 0.1134
Loa Loa (eye worm) hypothetical protein 0.0101 0.0282 0.3259
Schistosoma mansoni hypothetical protein 0.004 0.0074 0.0099
Schistosoma mansoni hypothetical protein 0.0165 0.0501 0.0675
Mycobacterium ulcerans acyl-CoA synthetase 0.0101 0.0282 0.0282
Brugia malayi hypothetical protein 0.0045 0.0091 0.1022
Loa Loa (eye worm) hypothetical protein 0.0031 0.0043 0.0465
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0004 0.0004
Schistosoma mansoni cpg binding protein 0.0154 0.0463 0.0624
Echinococcus granulosus GPCR family 2 0.0035 0.0057 0.0072
Mycobacterium ulcerans hypothetical protein 0.0101 0.0282 0.0282
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0045 0.0091 1
Echinococcus multilocularis lamin 0.0031 0.0043 0.0045
Leishmania major acetyl-CoA synthetase, putative 0.003 0.0039 0.0375
Plasmodium falciparum acyl-CoA synthetase 0.0075 0.0195 1
Schistosoma mansoni hypothetical protein 0.004 0.0074 0.0099
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0181 0.0178
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0421 0.4373
Echinococcus multilocularis protein dispatched 1 0.0047 0.0098 0.0106
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0541 0.1783 0.1783
Brugia malayi acetyl-Coenzyme A synthetase 2 0.003 0.0039 0.0418
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0024 0.0215
Echinococcus multilocularis neuroligin 0.0045 0.0091 0.0098
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.003 0.0039 0.0375
Brugia malayi AMP-binding enzyme family protein 0.0101 0.0282 0.3259
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0175 0.0236
Echinococcus granulosus microtubule associated protein 2 0.1444 0.486 0.6553
Loa Loa (eye worm) AMP-binding enzyme family protein 0.003 0.0039 0.0418
Onchocerca volvulus 0.0045 0.0091 0.1217
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0057 0.6216
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.024
Loa Loa (eye worm) hypothetical protein 0.0045 0.0091 0.1022
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0057 0.6216
Echinococcus multilocularis microtubule associated protein 2 0.1444 0.486 0.5437
Onchocerca volvulus 0.0045 0.0091 0.1217
Onchocerca volvulus 0.0154 0.0463 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0035 0.0057 0.6216
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0004 0.0095
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0327 0.1052 0.1418
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0421 0.4373
Loa Loa (eye worm) RNA binding protein 0.0069 0.0175 0.2006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0057 0.6216
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0024 0.1217
Trichomonas vaginalis antibiotic synthetase, putative 0.003 0.0039 0.4181
Loa Loa (eye worm) hypothetical protein 0.0075 0.0195 0.2242
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0057 0.6216
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0057 0.6216
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0045 0.0091 0.0087
Schistosoma mansoni hypothetical protein 0.2193 0.7414 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0048 0.0101 0.0109
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0175 0.0236
Brugia malayi CXXC zinc finger family protein 0.0154 0.0463 0.538
Schistosoma mansoni DNA polymerase eta 0.0019 0.0004 0.0004
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0101 0.0282 0.0244
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0024 0.1217
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0038 0.0069 0.0092
Echinococcus granulosus survival motor neuron protein 1 0.027 0.0858 0.1153
Loa Loa (eye worm) hypothetical protein 0.005 0.011 0.1247
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.003 0.0039 0.0087
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.0313 0.3624
Loa Loa (eye worm) hypothetical protein 0.0101 0.0282 0.3259
Schistosoma mansoni acetyl-CoA synthetase 0.003 0.0039 0.0053
Echinococcus multilocularis dnaJ subfamily B 0.2193 0.7414 0.8297
Echinococcus granulosus cpg binding protein 0.0163 0.0493 0.0661
Loa Loa (eye worm) oxidoreductase 0.003 0.0039 0.0418
Loa Loa (eye worm) carboxylesterase 0.0045 0.0091 0.1022
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0057 0.6216
Loa Loa (eye worm) hypothetical protein 0.0041 0.0079 0.0878
Mycobacterium tuberculosis Conserved hypothetical protein 0.0541 0.1783 0.178
Loa Loa (eye worm) hypothetical protein 0.003 0.0039 0.0418
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.0405 0.0542
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0057 0.6216
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0175 0.2006
Echinococcus granulosus lamin 0.0031 0.0043 0.0054
Echinococcus multilocularis geminin 0.0165 0.0501 0.0556
Trichomonas vaginalis spcc417.12 protein, putative 0.0045 0.0091 1
Entamoeba histolytica hypothetical protein 0.0117 0.0337 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0057 0.6216
Entamoeba histolytica acyl-coA synthetase, putative 0.0101 0.0282 0.8374
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0101 0.0282 0.0282
Entamoeba histolytica hypothetical protein 0.0117 0.0337 1
Echinococcus granulosus acetylcholinesterase 0.0265 0.0841 0.113
Schistosoma mansoni hypothetical protein 0.0117 0.0337 0.0454
Brugia malayi AMP-binding enzyme family protein 0.0101 0.0282 0.3259
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.0421 0.4373
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.004 0.0074 0.0099
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0101 0.0282 0.0279
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0079 0.0101
Schistosoma mansoni cpg binding protein 0.0163 0.0493 0.0665
Schistosoma mansoni acetylcholinesterase 0.0045 0.0091 0.0122
Echinococcus multilocularis acetylcholinesterase 0.0265 0.0841 0.0937
Echinococcus granulosus intermediate filament protein 0.0031 0.0043 0.0054
Echinococcus granulosus acetylcholinesterase 0.0265 0.0841 0.113
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0057 0.0072
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0117 0.0337 0.045
Loa Loa (eye worm) AMP-binding enzyme family protein 0.003 0.0039 0.0418
Brugia malayi AMP-binding enzyme family protein 0.003 0.0039 0.0418
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.003 0.0039 0.0036
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0045 0.0091 0.0118
Loa Loa (eye worm) hypothetical protein 0.027 0.0858 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0038 0.0069 0.0073
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0039 0.0036
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0057 0.0626
Loa Loa (eye worm) hypothetical protein 0.0075 0.0195 0.2242
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.003 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0075 0.0195 0.2242
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0057 0.6216
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.0313 0.3624
Trichomonas vaginalis helicase, putative 0.0035 0.0057 0.6216
Loa Loa (eye worm) hypothetical protein 0.0101 0.0282 0.3259
Entamoeba histolytica hypothetical protein 0.0117 0.0337 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0265 0.306
Brugia malayi Carboxylesterase family protein 0.0265 0.0841 0.9798
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0541 0.1783 1
Schistosoma mansoni cpg binding protein 0.0163 0.0493 0.0665
Leishmania major acetyl-CoA synthetase, putative 0.003 0.0039 0.0375
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0195 0.2236
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0175 0.0236
Onchocerca volvulus 0.0045 0.0091 0.1217
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0057 0.006
Echinococcus multilocularis carboxylesterase 5A 0.0265 0.0841 0.0937
Loa Loa (eye worm) hypothetical protein 0.0075 0.0195 0.2236
Echinococcus granulosus lamin dm0 0.0031 0.0043 0.0054
Schistosoma mansoni patched 1 0.0041 0.0079 0.0106
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.003 0.0039 0.0039
Echinococcus multilocularis GPCR, family 2 0.0035 0.0057 0.006
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0057 0.006
Brugia malayi Carboxylesterase family protein 0.0045 0.0091 0.1022
Schistosoma mansoni BC026374 protein (S09 family) 0.0045 0.0091 0.0122
Onchocerca volvulus 0.0101 0.0282 0.5724
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0014 0.0018
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0043 0.0465
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0175 0.0192
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0004 0.0004
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0045 0.0091 0.0122
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0113 0.1148
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0057 0.0072
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.003 0.0039 0.004
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.003 0.0039 0.0036
Schistosoma mansoni survival motor neuron protein 0.0055 0.0126 0.0169
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0175 0.2006
Schistosoma mansoni neuroligin 3 (S09 family) 0.0045 0.0091 0.0122
Loa Loa (eye worm) hypothetical protein 0.0045 0.0091 0.1022
Schistosoma mansoni hypothetical protein 0.0035 0.0057 0.0076
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0039 0.0039
Brugia malayi hypothetical protein 0.0025 0.0024 0.024
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.2952 1 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.0313 0.3624
Mycobacterium ulcerans acyl-CoA synthetase 0.0101 0.0282 0.0282
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.2952 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0057 0.0626
Loa Loa (eye worm) hypothetical protein 0.0035 0.0057 0.0626
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.0475 0.0472
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0101 0.0282 0.0282
Giardia lamblia DINP protein human, muc B family 0.0019 0.0004 0.5
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0079 0.0878
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.003 0.0039 0.0039
Echinococcus multilocularis survival motor neuron protein 1 0.027 0.0858 0.0957
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0181 0.0178
Echinococcus multilocularis neuropeptide receptor A26 0.0507 0.1665 0.1861
Onchocerca volvulus 0.0045 0.0091 0.1217
Onchocerca volvulus 0.0055 0.0126 0.2045
Schistosoma mansoni hypothetical protein 0.0055 0.0126 0.0169
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.003 0.0039 0.0375
Loa Loa (eye worm) hypothetical protein 0.0045 0.0091 0.1022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0057 0.6216
Brugia malayi TAR-binding protein 0.0069 0.0175 0.2006
Loa Loa (eye worm) hypothetical protein 0.0075 0.0195 0.2242
Loa Loa (eye worm) hypothetical protein 0.011 0.0313 0.3624
Mycobacterium ulcerans hypothetical protein 0.0541 0.1783 0.1783
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0175 0.2006
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0075 0.0195 0.0192
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0045 0.0091 0.0098
Toxoplasma gondii propionate-CoA ligase 0.003 0.0039 0.0087
Toxoplasma gondii hypothetical protein 0.0048 0.0103 0.0448
Echinococcus multilocularis para nitrobenzyl esterase 0.0045 0.0091 0.0098
Trypanosoma brucei acetyl-CoA synthetase, putative 0.003 0.0039 0.0375
Onchocerca volvulus 0.0031 0.0043 0.0094
Schistosoma mansoni gliotactin 0.0045 0.0091 0.0122
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0082 0.0819
Echinococcus granulosus neuroligin 0.0045 0.0091 0.0118
Loa Loa (eye worm) histone methyltransferase 0.0048 0.0101 0.1138
Brugia malayi RNA binding protein 0.0069 0.0175 0.2006
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0079 0.0084
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.0405 0.045
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0004 0.0004
Entamoeba histolytica acyl-CoA synthetase, putative 0.0101 0.0282 0.8374
Schistosoma mansoni hypothetical protein 0.0165 0.0501 0.0675
Echinococcus granulosus expressed conserved protein 0.009 0.0245 0.0326
Echinococcus granulosus carboxylesterase 5A 0.0265 0.0841 0.113
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0181 0.0178
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.003 0.0039 0.0036
Schistosoma mansoni hypothetical protein 0.0035 0.0057 0.0076
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.0958 1
Mycobacterium ulcerans hypothetical protein 0.0541 0.1783 0.1783
Leishmania major 4-coumarate:coa ligase-like protein 0.0101 0.0282 0.2919
Echinococcus granulosus mixed lineage leukemia protein mll 0.0038 0.0069 0.0088
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0043 0.0465
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0048 0.0101 0.0131
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.003 0.0039 0.0039
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0039 0.0039
Leishmania major mitochondrial DNA polymerase beta 0.0299 0.0958 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0004 0.0004
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0024 0.0215
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.264 0.8936 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0101 0.0282 0.0244
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0004 0.0149
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0024 0.0215
Brugia malayi Carboxylesterase family protein 0.0045 0.0091 0.1022
Brugia malayi Carboxylesterase family protein 0.0265 0.0841 0.9798
Onchocerca volvulus 0.0031 0.0043 0.0094
Plasmodium vivax acetyl-CoA synthetase, putative 0.003 0.0039 0.0892
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0039 0.0039
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.003 0.0039 0.0036
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0082 0.0819
Echinococcus multilocularis lamin dm0 0.0031 0.0043 0.0045
Schistosoma mansoni lamin 0.0031 0.0043 0.0058
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0079 0.0101
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0175 0.0236
Echinococcus multilocularis acetylcholinesterase 0.0265 0.0841 0.0937
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.003 0.0039 0.0039
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0265 0.0353
Brugia malayi AMP-binding enzyme family protein 0.003 0.0039 0.0418
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0082 0.0819
Entamoeba histolytica hypothetical protein 0.0117 0.0337 1
Echinococcus multilocularis expressed conserved protein 0.009 0.0245 0.0271
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0082 0.0819
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.003 0.0039 0.0375
Brugia malayi AMP-binding enzyme family protein 0.003 0.0039 0.0418
Loa Loa (eye worm) transcription factor SMAD2 0.025 0.079 0.9201
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.003 0.0039 0.0048
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.003 0.0039 0.0375
Echinococcus multilocularis musashi 0.0031 0.0043 0.0045
Brugia malayi AMP-binding enzyme family protein 0.0101 0.0282 0.3259
Loa Loa (eye worm) hypothetical protein 0.0045 0.0091 0.1022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0181 0.0178
Echinococcus multilocularis protein patched 0.0041 0.0079 0.0084
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0004 0.0149
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.003 0.0039 0.0418
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0075 0.0195 0.0195
Toxoplasma gondii histone lysine methyltransferase SET1 0.0292 0.0933 0.5166
Brugia malayi CHE-14 protein 0.0041 0.0079 0.0878
Brugia malayi AMP-binding enzyme family protein 0.003 0.0039 0.0418
Schistosoma mansoni hypothetical protein 0.0035 0.0057 0.0076
Plasmodium falciparum acetyl-CoA synthetase, putative 0.003 0.0039 0.2
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0057 0.6216
Loa Loa (eye worm) hypothetical protein 0.0265 0.0841 0.9798
Leishmania major hypothetical protein, conserved 0.0025 0.0024 0.0215
Brugia malayi hypothetical protein 0.0117 0.0337 0.3899
Brugia malayi hypothetical protein 0.027 0.0858 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0101 0.0282 0.8374
Brugia malayi intermediate filament protein 0.0031 0.0043 0.0465
Loa Loa (eye worm) hypothetical protein 0.003 0.0041 0.0443
Mycobacterium ulcerans hypothetical protein 0.0158 0.0475 0.0475
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0057 0.6216
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.003 0.0039 0.0039
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0045 0.0091 0.0087
Echinococcus multilocularis cpg binding protein 0.0163 0.0493 0.0548
Onchocerca volvulus 0.0045 0.0091 0.1217
Echinococcus multilocularis neuropeptide s receptor 0.0507 0.1665 0.1861
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0057 0.0626
Loa Loa (eye worm) hypothetical protein 0.003 0.0039 0.0418
Loa Loa (eye worm) hypothetical protein 0.0075 0.0195 0.2242
Echinococcus granulosus para nitrobenzyl esterase 0.0045 0.0091 0.0118
Loa Loa (eye worm) hypothetical protein 0.0045 0.0091 0.1022
Loa Loa (eye worm) hypothetical protein 0.0045 0.0091 0.1022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0057 0.6216
Echinococcus granulosus dnaJ subfamily B 0.2193 0.7414 1
Mycobacterium ulcerans acetyl-CoA synthetase 0.003 0.0039 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0175 0.0236
Schistosoma mansoni lamin 0.0031 0.0043 0.0058
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.2952 1 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.003 0.0039 0.0039
Echinococcus granulosus neuropeptide receptor A26 0.0507 0.1665 0.2242
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.027 0.0364
Loa Loa (eye worm) carboxylesterase 0.0045 0.0091 0.1022
Schistosoma mansoni hypothetical protein 0.0075 0.0195 0.0262
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0039 0.0039
Brugia malayi MH2 domain containing protein 0.025 0.079 0.9201
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.003 0.0039 0.0375
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.0958 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0101 0.0282 0.0282
Loa Loa (eye worm) carboxylesterase 0.0265 0.0841 0.9798
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0038 0.0069 0.0088
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0075 0.0195 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0541 0.1783 0.178
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0079 0.861
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0299 0.0958 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0045 0.0091 0.0087
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0126 0.1433
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0039 0.0036
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0057 0.6216
Schistosoma mansoni intermediate filament proteins 0.0031 0.0043 0.0058
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0101 0.0282 0.0282
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.003 0.0039 0.0087
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0265 0.0293
Echinococcus multilocularis BC026374 protein (S09 family) 0.0045 0.0091 0.0098
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.003 0.0039 0.0375
Loa Loa (eye worm) hypothetical protein 0.0265 0.0841 0.9798
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0039 0.0036
Mycobacterium ulcerans carboxylesterase, LipT 0.0045 0.0091 0.0091
Brugia malayi Carboxylesterase family protein 0.0045 0.0091 0.1022
Loa Loa (eye worm) CXXC zinc finger family protein 0.0154 0.0463 0.538
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0045 0.0091 0.0122
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0045 0.0091 0.0122
Loa Loa (eye worm) MH2 domain-containing protein 0.025 0.079 0.9201
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0025 0.0022
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0101 0.0282 0.0279
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0039 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0039 0.0039
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0039 0.0039
Plasmodium vivax acyl-CoA synthetase, putative 0.0075 0.0195 1
Brugia malayi F/Y-rich N-terminus family protein 0.0047 0.0099 0.1114
Leishmania major 4-coumarate:coa ligase-like protein 0.0101 0.0282 0.2919

Activities

Activity type Activity value Assay description Source Reference
Glucose transport (functional) = 120 % In vitro glucose transport activity in 3T3-LI adipocytes at 3 microM concentration. ChEMBL. 9667966
Glucose transport (functional) = 120 % In vitro glucose transport activity in 3T3-LI adipocytes at 3 microM concentration. ChEMBL. 9667966
Glucose transport (functional) = 282 % In vitro glucose transport activity in 3T3-LI adipocytes at 10 microM concentration. ChEMBL. 9667966
Glucose transport (functional) = 282 % In vitro glucose transport activity in 3T3-LI adipocytes at 10 microM concentration. ChEMBL. 9667966
Glucose transport (functional) = 352 % In vitro glucose transport activity in 3T3-LI adipocytes at 30 microM concentration. ChEMBL. 9667966
Glucose transport (functional) = 352 % In vitro glucose transport activity in 3T3-LI adipocytes at 30 microM concentration. ChEMBL. 9667966

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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