Detailed information for compound 1542815

Basic information

Technical information
  • TDR Targets ID: 1542815
  • Name: [2-(cyclopropylamino)-2-oxoethyl] 5,6-dichlor opyridine-3-carboxylate
  • MW: 289.115 | Formula: C11H10Cl2N2O3
  • H donors: 1 H acceptors: 3 LogP: 2.19 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC1CC1)COC(=O)c1cnc(c(c1)Cl)Cl
  • InChi: 1S/C11H10Cl2N2O3/c12-8-3-6(4-14-10(8)13)11(17)18-5-9(16)15-7-1-2-7/h3-4,7H,1-2,5H2,(H,15,16)
  • InChiKey: KKBCPZKTCLYRJA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(cyclopropylamino)-2-oxo-ethyl] 5,6-dichloropyridine-3-carboxylate
  • 5,6-dichloro-3-pyridinecarboxylic acid [2-(cyclopropylamino)-2-oxoethyl] ester
  • 5,6-dichloronicotinic acid [2-(cyclopropylamino)-2-keto-ethyl] ester
  • Oprea1_400932
  • T0517-1225
  • ZINC03350449
  • Enamine_005397

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.003 0.0156 0.0449
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0622 0.301
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0431 0.1486
Trichomonas vaginalis CAMK family protein kinase 0.005 0.036 0.118
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0042 0.0019
Trypanosoma brucei metacaspase MCA3 0.0019 0.0037 0.0002
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Loa Loa (eye worm) hypothetical protein 0.0048 0.034 0.1144
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0064 0.0511 0.0511
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0329 0.1063
Echinococcus multilocularis solute carrier family 22 0.003 0.0156 0.0156
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0156 0.0195
Mycobacterium ulcerans hypothetical protein 0.0024 0.0089 0.0197
Plasmodium vivax hexose transporter 0.0215 0.2071 0.2194
Brugia malayi Pre-SET motif family protein 0.0203 0.1948 0.7185
Loa Loa (eye worm) hypothetical protein 0.0086 0.0731 0.2614
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0329 0.1097
Plasmodium falciparum calcium-dependent protein kinase 1 0.0067 0.0534 0.0536
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0064 0.0511 0.1729
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0533 0.0533
Entamoeba histolytica hypothetical protein 0.0071 0.0581 0.1984
Schistosoma mansoni glucose transporter 0.003 0.0156 0.0146
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0067 0.0533 0.2553
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.1543 0.1543
Plasmodium vivax calcium-dependent protein kinase, putative 0.0067 0.0534 0.0536
Loa Loa (eye worm) hypothetical protein 0.0081 0.0678 0.2416
Mycobacterium ulcerans hypothetical protein 0.0024 0.0089 0.0197
Onchocerca volvulus 0.003 0.0156 0.0096
Onchocerca volvulus 0.003 0.0156 0.0096
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0042 0.002
Toxoplasma gondii lysine-tRNA ligase 0.0048 0.034 0.0496
Trypanosoma cruzi glucose transporter, putative 0.003 0.0156 0.0614
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0078 0.0067
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0156 1
Echinococcus multilocularis caspase 2 0.0062 0.049 0.049
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.035 0.1612
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0206 0.1362
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0329 0.1501
Trypanosoma brucei metacaspase MCA2 0.0019 0.0037 0.0002
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.035 0.0338
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Onchocerca volvulus 0.003 0.0156 0.0096
Echinococcus multilocularis caspase 0.0019 0.0037 0.0037
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0037 0.0001
Onchocerca volvulus Putative transporter 0.003 0.0156 0.0096
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0156 0.0449
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0156 0.0189
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0284 0.0345
Echinococcus multilocularis solute carrier family 22 0.003 0.0156 0.0156
Schistosoma mansoni glucose transport protein 0.0215 0.2071 0.2484
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.087 0.1058
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0448 0.0502
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0078 0.013
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0136 0.0165
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0089 0.0269
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0329 0.1063
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.084 0.2927
Schistosoma mansoni cpg binding protein 0.006 0.0465 0.0523
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0533 0.0606
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0533 0.0533
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0156 0.0961
Plasmodium falciparum calcium-dependent protein kinase 3 0.0067 0.0534 0.0536
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Onchocerca volvulus 0.003 0.0156 0.0096
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.084 0.2927
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0042 0.0019
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0078 0.3135
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0452
Echinococcus multilocularis expressed conserved protein 0.0093 0.0808 0.0808
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0581 0.0581
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0156 0.0435
Entamoeba histolytica hypothetical protein 0.0071 0.0581 0.1984
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.084 0.084
Schistosoma mansoni patched 1 0.0043 0.0284 0.0302
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0452
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0078 0.0211
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Onchocerca volvulus 0.003 0.0156 0.0096
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0678 0.0825
Brugia malayi hypothetical protein 0.0071 0.0581 0.2047
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0452
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0534 0.1811
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0078 0.0154
Loa Loa (eye worm) hypothetical protein 0.0047 0.0329 0.11
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0678 0.0784
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0058 0.0448 0.2115
Echinococcus granulosus dna polymerase kappa 0.0019 0.0037 0.0045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2781 1
Schistosoma mansoni alpha-glucosidase 0.0141 0.1307 0.1551
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0284 0.09
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0117 0.0306
Echinococcus multilocularis peregrin 0.0028 0.0136 0.0136
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.084 0.4131
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0186 0.1202
Onchocerca volvulus 0.0146 0.1362 0.5835
Giardia lamblia PHD finger protein 15 0.0028 0.0136 0.0361
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Brugia malayi CXXC zinc finger family protein 0.0057 0.0431 0.1483
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Schistosoma mansoni protein kinase 0.0067 0.0533 0.0606
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2781 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0452
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0452
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0067 0.0533 0.1867
Trypanosoma cruzi metacaspase, putative 0.0019 0.0037 0.0002
Loa Loa (eye worm) hypothetical protein 0.0049 0.035 0.1182
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0156 0.0449
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.034 0.037
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0448 0.2115
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.022 0.0668
Trichomonas vaginalis conserved hypothetical protein 0.0215 0.2071 0.7413
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0078 0.0154
Onchocerca volvulus 0.0057 0.0431 0.1406
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2781 1
Schistosoma mansoni alpha glucosidase 0.0036 0.022 0.0224
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0089 0.0197
Plasmodium falciparum calcium-dependent protein kinase 5 0.0067 0.0534 0.0536
Schistosoma mansoni hypothetical protein 0.0041 0.0268 0.0282
Loa Loa (eye worm) sugar transporter 0.003 0.0156 0.0452
Toxoplasma gondii sugar transporter ST3 0.003 0.0156 0.0195
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0231 0.0734
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0156 0.0435
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0329 0.2089
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.2781 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0348 0.3451 0.5589
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0329 0.1097
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0215 0.2071 0.2518
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.1311 0.1311
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.1278 0.4667
Giardia lamblia Kinase, PLK 0.0096 0.084 0.2927
Plasmodium falciparum phd finger protein, putative 0.0028 0.0136 0.0106
Onchocerca volvulus 0.0095 0.0826 0.3287
Trypanosoma brucei metacaspase 5, putative 0.0019 0.0037 0.0002
Trypanosoma brucei sugar transporter, putative 0.003 0.0156 0.0614
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0037 0.0003
Trypanosoma brucei glucosidase, putative 0.0036 0.022 0.0943
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0452
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.084 0.0981
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0136 0.0162
Brugia malayi hypothetical protein 0.0032 0.017 0.0502
Loa Loa (eye worm) hypothetical protein 0.0064 0.0511 0.1787
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0231 0.0281
Giardia lamblia Lysyl-tRNA synthetase 0.0048 0.034 0.1105
Leishmania major glucose transporter, lmgt1 0.0067 0.0534 0.2556
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0156 0.0449
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0678 0.0678
Brugia malayi jmjC domain containing protein 0.0093 0.0803 0.288
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0089 0.0197
Loa Loa (eye worm) hypothetical protein 0.0035 0.0206 0.0639
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.0265 0.1561
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0186 0.1202
Echinococcus granulosus caspase 0.0019 0.0037 0.0045
Entamoeba histolytica hypothetical protein 0.0048 0.034 0.1105
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.2781 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.2781 1
Trypanosoma brucei polo-like protein kinase 0.0096 0.084 0.4131
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0136 0.0106
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.035 0.1612
Schistosoma mansoni protein kinase 0.0067 0.0533 0.0606
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0156 0.0156
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0037 0.0001
Echinococcus granulosus lysyl tRNA synthetase 0.0048 0.034 0.0414
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0452
Trypanosoma brucei glucose transporter, putative 0.0067 0.0534 0.2556
Onchocerca volvulus 0.0047 0.0329 0.0917
Echinococcus granulosus calcium dependent protein kinase 0.0062 0.0483 0.0587
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.022 0.0268
Echinococcus granulosus mitogen activated protein kinase 3 0.0058 0.0448 0.0545
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0067 0.0534 0.0536
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0156 0.0435
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0156 0.0145
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.022 0.0668
Loa Loa (eye worm) hypothetical protein 0.0048 0.0345 0.1163
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.1277 0.1553
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0448 0.1499
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0132 0.016
Echinococcus granulosus apoptotic protease activating factor 1 0.0044 0.0295 0.0359
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0037 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2781 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0067 0.0534 0.0813
Plasmodium falciparum protein kinase 6 0.0912 0.9307 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0156 0.0145
Entamoeba histolytica protein kinase, putative 0.0067 0.0533 0.1809
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0156 0.0614
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2781 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0156 0.0156
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0058 0.0448 0.0673
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0048 0.034 0.1105
Loa Loa (eye worm) glutaminase 2 0.0275 0.2696 1
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0019 0.0037 0.0045
Loa Loa (eye worm) hypothetical protein 0.0064 0.0511 0.1787
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0448 0.1499
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0156 0.0146
Brugia malayi hypothetical protein 0.0049 0.035 0.1179
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.022 0.022
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0036 0.0036
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0058 0.0448 0.2115
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.022 0.0693
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0622 0.301
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0156 0.0435
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0037 0.0001
Leishmania major glucose transporter, lmgt3 0.0067 0.0534 0.2556
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0067 0.0534 0.0813
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0533 0.0533
Loa Loa (eye worm) hypothetical protein 0.0035 0.0206 0.0639
Trypanosoma cruzi metacaspase, putative 0.0019 0.0037 0.0002
Echinococcus granulosus dna polymerase eta 0.0019 0.0037 0.0045
Schistosoma mansoni protein kinase 0.0067 0.0533 0.0606
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0215 0.2071 0.2071
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0581 0.0707
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.045
Onchocerca volvulus 0.003 0.0156 0.0096
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0448 0.1499
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0284 0.0345
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0534 0.1811
Echinococcus multilocularis cpg binding protein 0.006 0.0465 0.0465
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Schistosoma mansoni alpha-glucosidase 0.0141 0.1307 0.1551
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0037 0.0001
Loa Loa (eye worm) hypothetical protein 0.0062 0.049 0.1705
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.084 0.3352
Loa Loa (eye worm) hypothetical protein 0.0047 0.0329 0.11
Trypanosoma brucei glucose transporter, putative 0.0067 0.0534 0.2556
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0089 0.019
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0019 0.0037 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.084 0.2927
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.022 0.0943
Onchocerca volvulus Cell death protein 3 homolog 0.0062 0.049 0.1684
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.034 0.1141
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0042 0.0027
Brugia malayi Cam kinase protein 1 0.0067 0.0533 0.1867
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0036 0.0044
Entamoeba histolytica protein kinase, putative 0.0067 0.0533 0.1809
Echinococcus multilocularis solute carrier family 22 0.003 0.0156 0.0156
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0042 0.0042
Onchocerca volvulus 0.003 0.0156 0.0096
Echinococcus multilocularis solute carrier family 22 0.003 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0452
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0096 0.0072
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0156 0.0449
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0534 0.1811
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.087 0.3135
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0251 0.0251
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0231 0.0237
Trypanosoma cruzi metacaspase 5, putative 0.0019 0.0037 0.0002
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0156 0.019
Schistosoma mansoni ap endonuclease 0.0019 0.0042 0.0007
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0129 0.0348
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0452
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0037 0.0001
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0251 0.0305
Schistosoma mansoni sugar transporter 0.003 0.0156 0.0146
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1277 0.1515
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0622 0.301
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0064 0.0511 0.3611
Mycobacterium ulcerans hypothetical protein 0.0047 0.0329 0.1097
Loa Loa (eye worm) hypothetical protein 0.0035 0.0206 0.0639
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0064 0.0511 0.1729
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0023 0.0079 0.0158
Loa Loa (eye worm) hypothetical protein 0.0035 0.0206 0.0639
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.022 0.0668
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0156 0.0452
Loa Loa (eye worm) hypothetical protein 0.0028 0.0136 0.0376
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0329 0.1097
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.084 0.2927
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0329 0.1063
Echinococcus granulosus dnaJ subfamily B 0.0808 0.8224 1
Trypanosoma brucei glucose transporter, putative 0.0067 0.0534 0.2556
Trypanosoma brucei glucose transporter, putative 0.0067 0.0534 0.2556
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0042 0.002
Plasmodium falciparum mitogen-activated protein kinase 2 0.0348 0.3451 0.3683
Onchocerca volvulus 0.0081 0.0678 0.2583
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0156 0.0961
Toxoplasma gondii sugar transporter ST1 0.003 0.0156 0.0195
Brugia malayi Glycosyl hydrolases family 31 protein 0.0164 0.1543 0.5665
Brugia malayi Sugar transporter family protein 0.0215 0.2071 0.7648
Schistosoma mansoni hypothetical protein 0.0022 0.007 0.0041
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0156 0.0452
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0534 0.1811
Loa Loa (eye worm) hypothetical protein 0.0035 0.0206 0.0639
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0067 0.0533 0.0648
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0078 0.0067
Echinococcus granulosus caspase 8 0.0019 0.0037 0.0045
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.022 0.0668
Schistosoma mansoni glucose transport protein 0.0215 0.2071 0.2484
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.035 0.0338
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0089 0.0108
Schistosoma mansoni kinase 0.0051 0.0373 0.0411
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0581 0.0665
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0037 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0067 0.0533 0.1809
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0156 0.0435
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0186 0.1202
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.1277 0.1277
Schistosoma mansoni hypothetical protein 0.0808 0.8224 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0064 0.0511 0.1784
Echinococcus granulosus peregrin 0.0028 0.0136 0.0165
Trypanosoma brucei hypothetical protein, conserved 0.0206 0.1981 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0042 0.0023
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0042 0.0027
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0089 0.0421
Trypanosoma cruzi hexose transporter, putative 0.0036 0.022 0.0945
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.022 0.0668
Onchocerca volvulus 0.003 0.0156 0.0095
Chlamydia trachomatis lysine--tRNA ligase 0.0048 0.034 1
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0156 0.019
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.034 0.037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1277 0.1515
Trypanosoma brucei glucose transporter 1E 0.0067 0.0534 0.2556
Brugia malayi major facilitator superfamily protein 0.003 0.0156 0.0449
Echinococcus multilocularis lysyl tRNA synthetase 0.0048 0.034 0.034
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0089 0.0269
Loa Loa (eye worm) hypothetical protein 0.0052 0.0386 0.1316
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.1948 0.7186
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0534 0.2556
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Brugia malayi MAP kinase sur-1 0.0058 0.0448 0.1547
Echinococcus multilocularis General substrate transporter 0.0185 0.1758 0.1758
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0156 0.0435
Leishmania major lysyl-tRNA synthetase, putative 0.0048 0.034 0.156
Brugia malayi glutaminase DH11.1 0.0275 0.2696 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.022 0.0668
Leishmania major hypothetical protein, conserved 0.0206 0.1981 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Trypanosoma brucei protein kinase, putative 0.0058 0.0448 0.2115
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.0969 0.1525
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.035 0.0338
Trypanosoma brucei glucose transporter 2A 0.0067 0.0534 0.2556
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0067 0.0533 0.0648
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.0265 0.184
Loa Loa (eye worm) hypothetical protein 0.0086 0.0731 0.2614
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.1277 0.4667
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0534 0.2556
Plasmodium falciparum hexose transporter 0.0215 0.2071 0.2194
Giardia lamblia Kinase, CMGC MAPK 0.0058 0.0448 0.1499
Loa Loa (eye worm) hypothetical protein 0.0043 0.0284 0.0932
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0058 0.0448 0.2115
Toxoplasma gondii facilitative glucose transporter GT1 0.0215 0.2071 0.3329
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0037 0.0001
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0622 0.301
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0329 0.2351
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0075 0.0622 0.0957
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0042 0.0279 0.0882
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0067 0.0534 0.0813
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Echinococcus multilocularis calcium dependent protein kinase 0.0062 0.0483 0.0483
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Trypanosoma cruzi metacaspase, putative 0.0019 0.0037 0.0002
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.035 0.1612
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.084 0.2927
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0067 0.0534 0.0536
Echinococcus multilocularis apoptotic protease activating factor 1 0.0044 0.0295 0.0295
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.1311 0.1595
Trichomonas vaginalis CAMK family protein kinase 0.005 0.036 0.118
Trypanosoma brucei glucose transporter, putative 0.0067 0.0534 0.2556
Loa Loa (eye worm) hypothetical protein 0.0052 0.0383 0.1305
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2781 1
Brugia malayi Sugar transporter family protein 0.003 0.0156 0.0449
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1277 0.1515
Trypanosoma brucei glucose transporter, putative 0.0067 0.0534 0.2556
Toxoplasma gondii exonuclease III APE 0.0019 0.0042 0.0008
Onchocerca volvulus 0.003 0.0156 0.0096
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0329 0.1097
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0534 0.2556
Brugia malayi Pre-SET motif family protein 0.003 0.0156 0.0447
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0067 0.0533 0.0648
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0156 0.0156
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.084 0.2927
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0329 0.1097
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0042 0.0019
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0156 0.0156
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0037 0.0045
Loa Loa (eye worm) hypothetical protein 0.0047 0.0329 0.11
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0452
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0329 0.2089
Leishmania major metacaspase, putative 0.0019 0.0037 0.0002
Schistosoma mansoni cpg binding protein 0.006 0.0465 0.0523
Schistosoma mansoni cpg binding protein 0.0057 0.0431 0.0482
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0136 0.0136
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0206 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0037 0.0001
Trichomonas vaginalis glucose transporter, putative 0.003 0.0156 0.0435
Giardia lamblia Prolyl-tRNA synthetase 0.0064 0.0511 0.1729
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.1278 1
Echinococcus granulosus mitogen activated protein kinase 0.0058 0.0448 0.0545
Loa Loa (eye worm) hypothetical protein 0.0067 0.0533 0.1869
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.1278 1
Entamoeba histolytica hypothetical protein 0.0023 0.0078 0.015
Onchocerca volvulus 0.003 0.0156 0.0096
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0156 0.0145
Onchocerca volvulus 0.003 0.0156 0.0096
Trichomonas vaginalis glucose transporter, putative 0.0067 0.0534 0.1811
Brugia malayi major facilitator superfamily protein 0.003 0.0156 0.0449
Mycobacterium ulcerans sugar transporter 0.003 0.0156 0.0449
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0089 0.0197
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0534 0.2556
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0448 0.1549
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.1277 0.4665
Echinococcus granulosus solute carrier family 22 0.003 0.0156 0.019
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0605 0.0694
Echinococcus multilocularis protein patched 0.0043 0.0284 0.0284
Schistosoma mansoni sugar transporter 0.003 0.0156 0.0146
Schistosoma mansoni hypothetical protein 0.0028 0.0136 0.0121
Entamoeba histolytica hypothetical protein 0.0071 0.0581 0.1984
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0037 0.0001
Brugia malayi hypothetical protein 0.003 0.0156 0.0449
Echinococcus granulosus expressed conserved protein 0.0093 0.0808 0.0983
Loa Loa (eye worm) hypothetical protein 0.0146 0.1362 0.4984
Schistosoma mansoni hypothetical protein 0.0041 0.0268 0.0282
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0511 0.058
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0215 0.2071 0.2071
Trypanosoma cruzi sugar transporter, putative 0.003 0.0156 0.0614
Echinococcus granulosus General substrate transporter 0.0185 0.1758 0.2137
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0215 0.2071 0.2071
Plasmodium vivax CDK-related protein kinase 6, putative 0.0912 0.9307 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0348 0.3451 0.3683
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.022 0.0668
Echinococcus multilocularis protein dispatched 1 0.0049 0.0346 0.0346
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0534 0.2556
Schistosoma mansoni hypothetical protein 0.0215 0.2071 0.2484
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.035 0.0513
Loa Loa (eye worm) sugar transporter 0.0215 0.2071 0.7649
Brugia malayi hypothetical protein 0.0146 0.1362 0.4982
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0042 0.0005
Schistosoma mansoni eyes absent homolog 0.0086 0.0731 0.0848
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0329 0.1097
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0452
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.084 0.302
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0186 0.1202
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0042 0.0019
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.084 0.1021
Treponema pallidum prolyl-tRNA synthetase 0.0023 0.0079 0.0134
Trichomonas vaginalis glutaminase, putative 0.0275 0.2696 0.9692
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.1277 0.1553
Brugia malayi CHE-14 protein 0.0043 0.0284 0.0929
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0231 0.0237
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.087 0.087
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0042 0.0005
Schistosoma mansoni glucose transport protein 0.0215 0.2071 0.2484
Echinococcus multilocularis mitogen activated protein kinase 0.0058 0.0448 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0534 0.1811
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.022 0.0668
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0452
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0156 0.0449
Echinococcus multilocularis mitogen activated protein kinase 3 0.0058 0.0448 0.0448
Leishmania major protein kinase, putative 0.0067 0.0533 0.2553
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0048 0.034 0.156
Chlamydia trachomatis proline--tRNA ligase 0.0023 0.0079 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0037 0.0001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0329 0.1097
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0329 0.1097
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0284 0.0932
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0678 0.2413
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.1981 1
Trypanosoma brucei glucose transporter, putative 0.0067 0.0534 0.2556
Onchocerca volvulus 0.0044 0.0295 0.0759
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.022 0.0668
Echinococcus multilocularis caspase 8 0.0019 0.0037 0.0037
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.022 0.069
Plasmodium vivax SET domain protein, putative 0.003 0.0156 0.0128
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0215 0.2071 0.2071
Plasmodium falciparum protein kinase 7 0.0608 0.6146 0.659
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0058 0.0448 0.1549
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0037 0.0001
Plasmodium falciparum calcium-dependent protein kinase 4 0.0067 0.0534 0.0536
Trichomonas vaginalis glucose transporter, putative 0.0067 0.0534 0.1811
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0005
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0041 0.0265 0.184
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.022 0.0668
Onchocerca volvulus 0.003 0.0156 0.0096
Toxoplasma gondii protein kinase, putative 0.0608 0.6146 1
Echinococcus granulosus cpg binding protein 0.006 0.0465 0.0565
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.022 0.0943
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0078 0.0211
Onchocerca volvulus 0.003 0.0156 0.0096
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0164 0.1543 0.5667
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0448 0.1499
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0206 0.4878
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.1102 0.1301
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0037 0.0001
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.084 0.4131
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0329 0.2351
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0329 0.1501
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0067 0.0533 0.0648
Brugia malayi Bromodomain containing protein 0.0028 0.0136 0.0372
Loa Loa (eye worm) hypothetical protein 0.0044 0.0295 0.0975
Echinococcus granulosus caspase 2 0.0062 0.049 0.0595
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2237 0.8017
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0064 0.0511 0.1784
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0058 0.0448 0.2115
Echinococcus granulosus solute carrier family 22 0.003 0.0156 0.019
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.1543 0.1543
Onchocerca volvulus 0.003 0.0156 0.0096
Brugia malayi hypothetical protein 0.003 0.0156 0.0449
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0037 0.0037
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0511 0.058
Leishmania major hypothetical protein, conserved 0.0049 0.035 0.1612
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2781 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0206 0.0182
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0089 0.0269
Echinococcus granulosus solute carrier family 22 0.003 0.0156 0.019
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.084 0.3022
Onchocerca volvulus 0.003 0.0156 0.0096
Giardia lamblia Sugar-proton symporter 0.003 0.0156 0.0435
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0078 0.0044
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0136 0.0376
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0048 0.034 0.2185
Echinococcus granulosus lysosomal alpha glucosidase 0.0164 0.1543 0.1877
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.1981 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0329 0.1097
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.022 0.03
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0206 0.0635
Echinococcus granulosus solute carrier family 22 0.003 0.0156 0.019
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0019 0.0037 0.0037
Brugia malayi jmjC domain containing protein 0.0037 0.0231 0.073
Leishmania major glucose transporter/membrane transporter D2, putative 0.0067 0.0534 0.2556
Brugia malayi hypothetical protein 0.0086 0.0731 0.2611
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0803 0.0803
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.084 0.2927
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0329 0.1097
Onchocerca volvulus 0.003 0.0156 0.0096
Leishmania major glucose transporter, lmgt2 0.0067 0.0534 0.2556
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0136 0.0162
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0156 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0156 0.0435
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0452
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0156 0.0614
Plasmodium falciparum proline--tRNA ligase 0.0075 0.0622 0.0631
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0037 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0003
Plasmodium vivax sugar transporter, putative 0.003 0.0156 0.0128
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0452
Schistosoma mansoni ap endonuclease 0.0019 0.0042 0.0007
Loa Loa (eye worm) hypothetical protein 0.0099 0.087 0.3137
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0803 0.0976
Trypanosoma brucei glucose transporter, putative 0.0067 0.0534 0.2556
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.084 0.2927
Plasmodium falciparum lysine--tRNA ligase 0.0048 0.034 0.0327
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0042 0.0051
Schistosoma mansoni glutaminase 0.0275 0.2696 0.3248
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0448 0.2115
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0886 0.1038
Schistosoma mansoni hypothetical protein 0.0071 0.0581 0.0665
Loa Loa (eye worm) glutaminase 0.0275 0.2696 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0215 0.2071 0.2518
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0078 0.0044
Trypanosoma cruzi hexose transporter, putative 0.003 0.0156 0.0614
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0156 0.0145
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0534 0.2556
Onchocerca volvulus 0.003 0.0156 0.0096
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0058 0.0448 0.2115
Echinococcus multilocularis dnaJ subfamily B 0.0808 0.8224 0.8224
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0037 0.0037
Trypanosoma cruzi metacaspase 5, putative 0.0019 0.0037 0.0002
Leishmania major hypothetical protein, conserved 0.003 0.0156 0.0614
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0136 0.0121
Brugia malayi hypothetical protein 0.0044 0.0295 0.0972
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.022 0.0943
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.034 0.1141
Plasmodium falciparum calcium-dependent protein kinase 2 0.0067 0.0534 0.0536
Schistosoma mansoni sugar transporter 0.003 0.0156 0.0146
Mycobacterium tuberculosis Conserved protein 0.0024 0.0089 0.0421
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0042 0.0043
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0067 0.0533 0.1869
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0042 0.0027
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0156 0.0449
Plasmodium vivax proline--tRNA ligase, putative 0.0075 0.0622 0.0631
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.007 0.007
Trypanosoma brucei Metacaspase-4 0.0019 0.0037 0.0002
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.2781 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0067 0.0533 0.0533
Schistosoma mansoni caspase-7 (C14 family) 0.0062 0.049 0.0553
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0197 0.0197
Onchocerca volvulus 0.0231 0.2237 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.1277 0.1277
Plasmodium vivax lysine--tRNA ligase, putative 0.0048 0.034 0.0327
Mycobacterium ulcerans glutaminase 0.0275 0.2696 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.007 0.0086
Schistosoma mansoni hypothetical protein 0.0044 0.0295 0.0316
Trichomonas vaginalis sugar transporter, putative 0.003 0.0156 0.0435
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0067 0.0533 0.1869
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0089 0.0089
Trypanosoma cruzi hexose transporter 0.0067 0.0534 0.2556
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0622 0.301
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.022 0.0668
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0284 0.0284
Giardia lamblia Hexose transporter 0.003 0.0156 0.0435
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0215 0.2071 0.2518
Entamoeba histolytica hypothetical protein 0.0071 0.0581 0.1984
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0329 0.1501
Toxoplasma gondii sugar transporter ST2 0.003 0.0156 0.0195
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0064 0.0511 0.0622
Schistosoma mansoni sugar transporter 0.003 0.0156 0.0146
Loa Loa (eye worm) hypothetical protein 0.003 0.0156 0.0452
Trypanosoma cruzi metacaspase, putative 0.0019 0.0037 0.0002
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.084 0.4131
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0048 0.034 0.156
Brugia malayi PHD-finger family protein 0.0028 0.0136 0.0372
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0078 0.0331
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0042 0.0027
Schistosoma mansoni hypothetical protein 0.0041 0.0268 0.0282
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.087 0.3038
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0215 0.2071 0.2518
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.2781 1
Brugia malayi lysyl-tRNA synthetase 0.0048 0.034 0.1141
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0067 0.0534 0.0536
Schistosoma mansoni hypothetical protein 0.0041 0.0268 0.0282
Brugia malayi Sugar transporter family protein 0.003 0.0156 0.0449
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0156 0.0194
Trypanosoma brucei metacaspase 0.0019 0.0037 0.0002
Echinococcus multilocularis dna polymerase eta 0.0019 0.0037 0.0037
Brugia malayi Cell death protein 3 precursor 0.0062 0.049 0.1703
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0019 0.0037 0.0001

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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