Detailed information for compound 1546376

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 327.811 | Formula: C17H18ClN5
  • H donors: 0 H acceptors: 3 LogP: 4.21 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)n1ncc2c1ncnc2N1CCCCC1C
  • InChi: 1S/C17H18ClN5/c1-12-4-2-3-9-22(12)16-15-10-21-23(17(15)20-11-19-16)14-7-5-13(18)6-8-14/h5-8,10-12H,2-4,9H2,1H3
  • InChiKey: WAFHVZXPHPIFBG-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0065 0.0065
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0168 0.0168
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0017 0.0472
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0002 0.0043
Echinococcus multilocularis protein dispatched 1 0.0047 0.0238 0.0238
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0136 0.0136
Echinococcus granulosus GPCR family 2 0.0033 0.0137 0.0137
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0065 0.0065
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0155 0.0613
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0002 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0363 0.2537 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0017 0.0068
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0243 0.0957
Loa Loa (eye worm) CXXC zinc finger family protein 0.0087 0.0534 0.2105
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0136 0.0536
Schistosoma mansoni hypothetical protein 0.0033 0.0137 0.0137
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0363 0.143
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0137 0.054
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0174 0.0687
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0017 0.0217
Loa Loa (eye worm) hypothetical protein 0.0035 0.0156 0.0615
Schistosoma mansoni microtubule-associated protein tau 0.1389 1 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0017 0.0068
Loa Loa (eye worm) hypothetical protein 0.0103 0.0651 0.2566
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0155 0.0613
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0038 0.0038
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0174 0.0687
Echinococcus granulosus expressed conserved protein 0.0089 0.0549 0.0549
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0002 0.0006
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0155 0.4282
Trichomonas vaginalis helicase, putative 0.002 0.0043 0.0169
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0243 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0174 0.4802
Giardia lamblia Macrophage migration inhibitory factor 0.0363 0.2537 0.5
Brugia malayi Doublecortin family protein 0.0019 0.0038 0.0148
Echinococcus multilocularis expressed conserved protein 0.0089 0.0549 0.0549
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0002 0.0006
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0651 0.2566
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0174 0.0687
Loa Loa (eye worm) hypothetical protein 0.0047 0.0243 0.0957
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0363 0.2537 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0156 0.0615
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0174 0.4802
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0651 0.2566
Brugia malayi hypothetical protein 0.0035 0.0152 0.0599
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0888 0.0888
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0043 0.0169
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0148
Echinococcus multilocularis tumor protein p63 0.0326 0.2273 0.2273
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0363 0.0363
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0243 0.3082
Loa Loa (eye worm) hepatopoietin HPO2 0.0035 0.0155 0.0613
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0196 0.0772
Schistosoma mansoni hypothetical protein 0.0039 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0035 0.0156 0.0615
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0155 0.0613
Brugia malayi hypothetical protein 0.0019 0.0038 0.0148
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0002 0.0009
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0363 0.2537 1
Brugia malayi Bm-MIF-1, identical 0.0363 0.2537 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0065 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0136 0.0136
Echinococcus granulosus tumor protein p63 0.0326 0.2273 0.2273
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0043 0.0169
Onchocerca volvulus 0.0048 0.0247 0.1465
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0038 0.0148
Echinococcus granulosus RUN 0.0019 0.0038 0.0038
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.1139 0.449
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0137 0.0137
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0243 0.3082
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0788 0.0788
Loa Loa (eye worm) hypothetical protein 0.0048 0.0247 0.0972
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0363 0.2537 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.1139 0.1139
Schistosoma mansoni rab6-interacting 0.0019 0.0038 0.0038
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0137 0.0137
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0155 0.0613
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0043 0.0169
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0142 0.1801
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0017
Echinococcus multilocularis RUN 0.0019 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0047 0.0243 0.0957
Schistosoma mansoni hypothetical protein 0.0039 0.0185 0.0185
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0243 0.3082
Entamoeba histolytica hypothetical protein 0.0035 0.0152 0.0599
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0243 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0788 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0243 0.0957
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0002 0.0006
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.0788 0.3106
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0043 0.0169
Entamoeba histolytica hypothetical protein 0.0035 0.0152 0.0599
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0174 0.0687
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0043 0.0169
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0243 0.0957
Echinococcus multilocularis protein patched 0.0041 0.0196 0.0196
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0137 0.054
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.0788 1
Schistosoma mansoni cpg binding protein 0.0092 0.057 0.057
Onchocerca volvulus 0.0099 0.0616 0.3662
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0043 0.0169
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0363 1
Schistosoma mansoni lipoxygenase 0.0019 0.0038 0.0038
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0155 0.4282
Schistosoma mansoni hypothetical protein 0.0039 0.0185 0.0185
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0104 0.0104
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0017 0.0472
Onchocerca volvulus 0.0019 0.0038 0.0223
Schistosoma mansoni loxhd1 0.0019 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0071 0.0413 0.1628
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0017 0.0068
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0156 0.0615
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0006
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0002 0.0006
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0243 0.3082
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0363 0.143
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0043 0.0169
Echinococcus granulosus dnaJ subfamily B 0.1243 0.8942 0.8942
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0053 0.0287 0.0287
Schistosoma mansoni hypothetical protein 0.0033 0.0137 0.0137
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0591 0.2329
Mycobacterium ulcerans hypothetical protein 0.0047 0.0243 0.3082
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0243 0.3082
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0413 0.1628
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0038 0.0038
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0196 0.0196
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0002 0.0006
Brugia malayi Pre-SET motif family protein 0.0033 0.0136 0.0536
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.0788 0.0788
Brugia malayi CXXC zinc finger family protein 0.0087 0.0534 0.2105
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0002 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0043 0.0169
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0017 0.0068
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0174 0.0687
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0002 0.0006
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0002 0.0006
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0363 0.143
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0017 0.0068
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0152 0.0152
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0152 0.0152
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0243 0.3082
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0174 0.0687
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0591 0.0591
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.5596 0.5596
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0174 0.0687
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0174 0.0174
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0156 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0136 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0043 0.0169
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0363 0.2537 1
Onchocerca volvulus 0.0033 0.0136 0.0808
Onchocerca volvulus 0.0245 0.1683 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0156 0.0615
Loa Loa (eye worm) hypothetical protein 0.0047 0.0243 0.0957
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0363 1
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0243 0.0957
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0788 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.1139 0.449
Toxoplasma gondii histone lysine methyltransferase SET1 0.0167 0.111 0.4376
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0243 0.0957
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0174 0.0174
Onchocerca volvulus 0.0047 0.0243 0.1443
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0363 1
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0038 0.0148
Brugia malayi CHE-14 protein 0.0041 0.0196 0.0772
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0065 0.0065
Schistosoma mansoni patched 1 0.0041 0.0196 0.0196
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.0788 0.3106
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0155 0.4282
Schistosoma mansoni hypothetical protein 0.0033 0.0137 0.0137
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0186 0.1254 0.1254
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.0788 0.0788
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0065 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0136 0.0136
Echinococcus multilocularis cpg binding protein 0.0092 0.057 0.057
Loa Loa (eye worm) hypothetical protein 0.005 0.0263 0.1036
Entamoeba histolytica hypothetical protein 0.0035 0.0152 0.0599
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0038 0.0038
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0196 0.0196
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0043 0.0169
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0243 0.0957
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0363 0.0363
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0002 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0043 0.0169
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0017
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0155 0.4282
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0038 0.0038
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0002 0.0043
Schistosoma mansoni hypothetical protein 0.0033 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0035 0.0156 0.0615
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0174 0.0687
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0152 0.0152
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.1139 0.1139
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0142 0.1801
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0017 0.0472
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0155 0.1024 0.4038
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0155 0.1024 0.4038
Plasmodium vivax SET domain protein, putative 0.0033 0.0136 0.0536
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0043 0.0169
Onchocerca volvulus 0.0087 0.0534 0.3173
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0363 0.2537 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0019 0.0038 0.0038
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0243 0.0957
Echinococcus multilocularis GPCR, family 2 0.0033 0.0137 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0043 0.0169
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0136 0.0136
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0243 0.3082
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0043 0.0169
Leishmania major macrophage migration inhibitory factor-like protein 0.0363 0.2537 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0243 0.0957
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0137 0.054
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0017 0.0068
Schistosoma mansoni hypothetical protein 0.0071 0.0413 0.0413
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0363 0.143
Loa Loa (eye worm) hypothetical protein 0.0033 0.0137 0.054
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0243 0.0957
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0035 0.0155 0.0155
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0243 0.3082
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0101 0.0399
Schistosoma mansoni alpha-glucosidase 0.0147 0.0966 0.0966
Schistosoma mansoni alpha-glucosidase 0.0147 0.0966 0.0966
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0142 0.1801
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0137 0.0137
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0136 0.0136
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0017 0.0017
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0043 0.0169
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0243 0.3082
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0174 0.0687
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0156 0.1979
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0053 0.0287 0.0287
Schistosoma mansoni hypothetical protein 0.0035 0.0152 0.0152
Brugia malayi Pre-SET motif family protein 0.0216 0.1468 0.5786
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0247 0.0247
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0038 0.0038
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0174 0.0687
Trichomonas vaginalis set domain proteins, putative 0.0245 0.1683 0.6633
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0136 0.0136
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0104 0.0409
Brugia malayi isocitrate dehydrogenase 0.0016 0.0017 0.0068
Loa Loa (eye worm) hypothetical protein 0.0095 0.0591 0.2329
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.0788 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0104 0.0104
Plasmodium falciparum macrophage migration inhibitory factor 0.0363 0.2537 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0174 0.0687
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0174 0.0687
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0196 0.0196
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0137 0.0137
Echinococcus multilocularis microtubule associated protein 2 0.1389 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0043 0.0169
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0017
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0591 0.0591
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0043 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0196 0.0772
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0174 0.0687
Brugia malayi hypothetical protein 0.0019 0.0038 0.0148
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0602 0.0602
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0017 0.0068
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.1139 0.1139
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0035 0.0155 0.0155
Schistosoma mansoni cpg binding protein 0.0087 0.0534 0.0534
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0888 0.0888
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0002 0.0043
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0114 0.0114
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0038 0.0148
Leishmania major hypothetical protein, conserved 0.0035 0.0155 0.0613
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0156 0.1979
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0017 0.0017
Echinococcus granulosus cpg binding protein 0.0092 0.057 0.057
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0142 0.1801
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0168 0.0168
Onchocerca volvulus 0.0019 0.0038 0.0223
Echinococcus multilocularis dnaJ subfamily B 0.1243 0.8942 0.8942
Schistosoma mansoni polycystin 1-related 0.0019 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0039 0.0185 0.0185
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0591 0.2329
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0017 0.0017
Leishmania major macrophage migration inhibitory factor-like protein 0.0363 0.2537 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.1468 0.5786
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0651 0.2566
Trypanosoma brucei glucosidase, putative 0.0038 0.0174 0.4802
Loa Loa (eye worm) hypothetical protein 0.0041 0.0196 0.0772
Schistosoma mansoni rab6-interacting 0.0019 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0148
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0017 0.0017
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0033 0.0136 0.0536
Schistosoma mansoni lipoxygenase 0.0053 0.0287 0.0287
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0017 0.0472
Schistosoma mansoni cpg binding protein 0.0092 0.057 0.057
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0174 0.0687
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.0788 0.0788
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0363 0.0363
Loa Loa (eye worm) hypothetical protein 0.0035 0.0156 0.0615
Entamoeba histolytica hypothetical protein 0.0035 0.0152 0.0599
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0174 0.0687
Brugia malayi Augmenter of liver regeneration 0.0035 0.0155 0.0613
Schistosoma mansoni hypothetical protein 0.1243 0.8942 0.8942
Schistosoma mansoni alpha glucosidase 0.0038 0.0174 0.0174

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 0.00838 uM PUBCHEM_BIOASSAY: Amyloid Precursor 5' UTR neuroblastoma cell reporter line Measured in Cell-Based System Using Plate Reader - 2078-04_Inhibitor_Dose_DryPowder_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488894] ChEMBL. No reference
AC50 (functional) = 0.018 uM PUBCHEM_BIOASSAY: Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_Dose_DryPowder_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488894] ChEMBL. No reference
AC50 (functional) = 0.074 uM PUBCHEM_BIOASSAY: H4 neuroblastoma control for prion reporter construct Measured in Cell-Based System Using Plate Reader - 2078-03_Inhibitor_Dose_DryPowder_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488894] ChEMBL. No reference
AC50 (binding) = 4.19 uM PUBCHEM_BIOASSAY: Assay of luciferase inhibitors in dose Measured in Biochemical System Using Plate Reader - 2078-05_Inhibitor_Dose_DryPowder_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488894] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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