TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 532.013 | Formula: C27H22ClN5O3S
H donors: 0 H acceptors: 6 LogP: 2.88 Rotable bonds: 5
Rule of 5 violations (Lipinski): 2
SMILES: CCOC1=C2[C@H](c3ccccc3Cl)N(C[C@H]2C(C(C1)(C#N)C#N)(C#N)C#N)S(=O)(=O)c1ccc(cc1)C
InChi: 1S/C27H22ClN5O3S/c1-3-36-23-12-26(14-29,15-30)27(16-31,17-32)21-13-33(37(34,35)19-10-8-18(2)9-11-19)25(24(21)23)20-6-4-5-7-22(20)28/h4-11,21,25H,3,12-13H2,1-2H3/t21-,25+/m1/s1
InChiKey: KIZXBEIYCACNQS-BWKNWUBXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	glutaminase	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	glutaminase 2	Get druggable targets OG5_129245	All targets in OG5_129245
Mycobacterium ulcerans	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trichomonas vaginalis	glutaminase, putative	Get druggable targets OG5_129245	All targets in OG5_129245
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	glutaminase DH11.1	Get druggable targets OG5_129245	All targets in OG5_129245
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	smad	0.001	0.0063	0.0063
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0048	0.5
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0048	0.0125
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.1629	0.4291
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0516	0.1359
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0008	0.0048	0.0147
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Echinococcus granulosus	cathepsin L	0.0008	0.0048	0.0147
Brugia malayi	nuclear hormone receptor	0.0005	0.0003	0.0008
Onchocerca volvulus		0.0008	0.0048	0.1563
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0841	0.2214
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0064	0.0168
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0008	0.0048	0.5
Brugia malayi	orphan nuclear receptor NR2E1	0.0005	0.0003	0.0008
Echinococcus granulosus	mothers against decapentaplegic 5	0.001	0.0063	0.0195
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0008	0.0048	0.5
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0005	0.001	0.0025
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0037	0.0115
Brugia malayi	Cathepsin L-like precursor	0.0008	0.0048	0.0125
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0048	0.5
Onchocerca volvulus		0.0008	0.0048	0.1563
Echinococcus multilocularis	cpg binding protein	0.0032	0.0325	0.0325
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0093	0.1036	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0064	0.0168
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0037	0.0115
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0048	0.0048
Brugia malayi	Papain family cysteine protease containing protein	0.0008	0.0048	0.0125
Echinococcus granulosus	cysteine protease	0.0008	0.0048	0.0147
Plasmodium vivax	vivapain-1	0.0008	0.0048	0.5
Schistosoma mansoni	nuclear receptor	0.0005	0.0003	0.0008
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0005	0.001	0.0026
Onchocerca volvulus		0.0008	0.0048	0.1563
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0048	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0841	0.2214
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0008	0.0048	0.0048
Brugia malayi	hypothetical protein	0.0005	0.001	0.0025
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0059	0.0182
Loa Loa (eye worm)	hypothetical protein	0.001	0.0064	0.0168
Echinococcus granulosus	cathepsin l1	0.0008	0.0048	0.0147
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0064	0.0168
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0005	0.0003	0.0008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Brugia malayi	tailless protein	0.0005	0.0003	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0012	0.0032
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0008	0.0048	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0048	0.0048
Onchocerca volvulus		0.0008	0.0048	0.1563
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0305	0.0803
Plasmodium falciparum	serine repeat antigen 2	0.0008	0.0048	0.5
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0064	0.0168
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0048	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0516	0.1591
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0048	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0064	0.0168
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0048	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0064	0.0197
Brugia malayi	MH1 domain containing protein	0.001	0.0063	0.0167
Brugia malayi	nuclear receptor RXR	0.0005	0.001	0.0025
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0008	0.0048	0.0125
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0064	0.0197
Brugia malayi	Cathepsin L-like precursor	0.0008	0.0048	0.0125
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0064	0.0197
Schistosoma mansoni	cathepsin F (C01 family)	0.0008	0.0048	0.0126
Plasmodium vivax	unspecified product	0.0008	0.0048	0.5
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0841	0.2214
Brugia malayi	cathepsin L-like cysteine proteinase	0.0008	0.0048	0.0125
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0008	0.0048	0.0048
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0005	0.0003	0.0008
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0059	0.0059
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0008	0.0048	0.0048
Plasmodium vivax	unspecified product	0.0008	0.0048	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0048	0.0125
Echinococcus multilocularis	cathepsin b	0.0283	0.3242	0.3242
Giardia lamblia	Cathepsin B precursor	0.0093	0.1036	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0008
Echinococcus multilocularis	cysteine protease	0.0008	0.0048	0.0048
Brugia malayi	Papain family cysteine protease containing protein	0.0008	0.0048	0.0125
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0064	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0005	0.001	0.0025
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0048	0.5
Mycobacterium ulcerans	glutaminase	0.033	0.3797	0.5
Loa Loa (eye worm)	nuclear factor I	0.0005	0.0012	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0005	0.001	0.0025
Schistosoma mansoni	cathepsin F (C01 family)	0.0008	0.0048	0.0126
Schistosoma mansoni	glutaminase	0.033	0.3797	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0064	0.0064
Brugia malayi	MH1 domain containing protein	0.0005	0.0012	0.0032
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0064	0.0168
Brugia malayi	MH2 domain containing protein	0.0144	0.1629	0.4291
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0048	0.5
Brugia malayi	RNA binding protein	0.0076	0.0841	0.2214
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.0623	0.5826
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0008	0.0048	0.0126
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0093	0.1036	1
Schistosoma mansoni	smad1 5 8 and	0.001	0.0063	0.0167
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0008	0.0048	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0064	0.0168
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0841	0.2214
Brugia malayi	nuclear receptor NHR-88	0.001	0.0064	0.0168
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0516	0.0516
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0008
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0283	0.3242	0.854
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0005	0.0003	0.01
Echinococcus granulosus	Smad4	0.001	0.0063	0.0195
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0093	0.1036	0.3093
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0008	0.0048	0.0048
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0008	0.0048	0.0126
Brugia malayi	nuclear hormone receptor	0.001	0.0064	0.0168
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0064	0.0168
Schistosoma mansoni	cathepsin F (C01 family)	0.0008	0.0048	0.0126
Brugia malayi	fibroinase precursor	0.0008	0.0048	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0048	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0008
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0008	0.0048	0.5
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0008	0.0048	0.5
Giardia lamblia	Cathepsin B precursor	0.0093	0.1036	1
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0048	0.5
Loa Loa (eye worm)	hypothetical protein	0.0005	0.001	0.0025
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0008	0.0048	0.5
Brugia malayi	Nuclear hormone receptor E75	0.0005	0.0003	0.0008
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0064	0.0168
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.001	0.0025
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0064	0.0168
Brugia malayi	hypothetical protein	0.0005	0.001	0.0025
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0005	0.0003	0.0003
Echinococcus granulosus	thyroid hormone receptor alpha	0.0005	0.0003	0.0009
Loa Loa (eye worm)	hypothetical protein	0.001	0.0064	0.0168
Echinococcus multilocularis	cathepsin L	0.0008	0.0048	0.0048
Echinococcus granulosus	nuclear receptor nhr 48	0.0005	0.0003	0.0009
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0064	0.0197
Schistosoma mansoni	cathepsin B (C01 family)	0.0008	0.0048	0.0126
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0008	0.0048	0.5
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0048	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Echinococcus multilocularis	mothers against decapentaplegic 5	0.001	0.0063	0.0063
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0008	0.0048	0.0125
Onchocerca volvulus	Cathepsin L homolog	0.0008	0.0048	0.1563
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0064	0.0064
Entamoeba histolytica	cysteine proteinase 2	0.0008	0.0048	0.5
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0005	0.0003	0.0003
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0048	0.0048
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0008	0.0048	0.0048
Plasmodium vivax	serine-repeat antigen (SERA)	0.0008	0.0048	0.5
Onchocerca volvulus		0.0005	0.0003	0.01
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0005	0.0003	0.0008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0008	0.0048	0.0048
Entamoeba histolytica	hypothetical protein	0.0008	0.0048	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.001	0.0025
Echinococcus multilocularis	nuclear receptor nhr 48	0.0005	0.0003	0.0003
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0005	0.001	0.001
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0064	0.0168
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0064	0.0064
Echinococcus multilocularis	cathepsin L	0.0008	0.0048	0.0048
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0064	0.0064
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0064	0.0168
Plasmodium falciparum	serine repeat antigen 6	0.0008	0.0048	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0283	0.3242	0.854
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0008	0.0048	0.5
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0841	0.2592
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0064	0.0168
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0003	0.0008
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0005	0.0003	0.0009
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0064	0.2093
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0064	0.0168
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0008	0.0048	0.5
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0005	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.001	0.0064	0.0168
Plasmodium falciparum	serine repeat antigen 9	0.0008	0.0048	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Plasmodium falciparum	serine repeat antigen 4	0.0008	0.0048	0.5
Brugia malayi	cathepsin F-like cysteine proteinase	0.0008	0.0048	0.0125
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0516	0.1591
Plasmodium falciparum	serine repeat antigen 1	0.0008	0.0048	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0003	0.0008
Brugia malayi	Cathepsin L-like precursor	0.0008	0.0048	0.0125
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0008	0.0048	0.0126
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0008	0.0048	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0008	0.0048	0.0126
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0008	0.0048	0.5
Loa Loa (eye worm)	cysteine protease	0.0008	0.0048	0.0125
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0005	0.0003	0.0009
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0008	0.0048	0.0048
Onchocerca volvulus		0.0008	0.0048	0.1563
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0841	0.2214
Loa Loa (eye worm)	hypothetical protein	0.0005	0.001	0.0025
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0048	0.5
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0005	0.0003	0.01
Plasmodium falciparum	serine repeat antigen 7	0.0008	0.0048	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0005	0.001	0.0026
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0048	0.5
Trichomonas vaginalis	glutaminase, putative	0.033	0.3797	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0008	0.0048	0.0126
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0048	0.5
Loa Loa (eye worm)	hypothetical protein	0.001	0.0064	0.0168
Schistosoma mansoni	nuclear receptor nhr-48	0.0005	0.0003	0.0008
Brugia malayi	hypothetical protein	0.0005	0.0003	0.0008
Brugia malayi	steroid hormone receptor	0.001	0.0064	0.0168
Entamoeba histolytica	cysteine proteinase 1, putative	0.0008	0.0048	0.5
Brugia malayi	Cathepsin L-like precursor	0.0008	0.0048	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0048	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0048	0.0125
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0048	0.5
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0064	0.0168
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Onchocerca volvulus		0.0008	0.0048	0.1563
Plasmodium falciparum	serine repeat antigen 5	0.0008	0.0048	0.5
Loa Loa (eye worm)	hypothetical protein	0.0005	0.001	0.0025
Schistosoma mansoni	smad1 5 8 and	0.001	0.0063	0.0167
Schistosoma mansoni	smad1 5 8 and	0.001	0.0063	0.0167
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0516	0.1359
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0283	0.3242	0.854
Brugia malayi	TAR-binding protein	0.0076	0.0841	0.2214
Schistosoma mansoni	zinc finger protein	0.0005	0.0003	0.0008
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0048	0.0048
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0008	0.0048	0.0125
Brugia malayi	MH1 domain containing protein	0.001	0.0063	0.0167
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0064	0.0168
Brugia malayi	Papain family cysteine protease containing protein	0.0008	0.0048	0.0125
Plasmodium vivax	vivapain-3	0.0008	0.0048	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0048	0.0048
Schistosoma mansoni	nuclear receptor	0.0005	0.0003	0.0008
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0064	0.0168
Echinococcus granulosus	cathepsin L cysteine protease	0.0008	0.0048	0.0147
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0841	0.2214
Echinococcus granulosus	cathepsin l1	0.0008	0.0048	0.0147
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0008	0.0048	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0064	0.0168
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0008	0.0048	0.0048
Schistosoma mansoni	cathepsin C	0.0008	0.0048	0.0126
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0008	0.0048	0.0126
Loa Loa (eye worm)	ctsf protein	0.0008	0.0048	0.0125
Giardia lamblia	Cathepsin B precursor	0.0093	0.1036	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0048	0.0048
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0008	0.0048	0.0126
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0008	0.0048	0.5
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0008
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0005	0.0003	0.0008
Brugia malayi	Papain family cysteine protease containing protein	0.0008	0.0048	0.0125
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0064	0.0064
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0064	0.0064
Echinococcus granulosus	cathepsin L	0.0008	0.0048	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0048	0.0125
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0064	0.0168
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0008	0.0048	0.0126
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0048	0.0048
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.001	0.0063	0.0167
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0064	0.0168
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0064	0.0168
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0065	0.0704	0.1854
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0008	0.0048	0.0048
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0064	0.0168
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0008	0.0048	0.0126
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0064	0.0168
Loa Loa (eye worm)	hypothetical protein	0.001	0.0064	0.0168
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0064	0.0197
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0841	0.2214
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0008	0.0048	0.0126
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0841	0.2214
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0516	0.0516
Onchocerca volvulus		0.001	0.0064	0.2093
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0008
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.1629	0.4291
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.001	0.0064	0.0168
Onchocerca volvulus	Cathepsin L homolog	0.0008	0.0048	0.1563
Onchocerca volvulus		0.0005	0.0003	0.01
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0048	0.0125
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0064	0.0197
Schistosoma mansoni	cpg binding protein	0.0032	0.0325	0.0857
Loa Loa (eye worm)	DR-78	0.0005	0.0003	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0048	0.0125
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0048	0.5
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0048	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0093	0.1036	0.2671
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0008	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0008
Onchocerca volvulus	Cathepsin F homolog	0.0008	0.0048	0.1563
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0048	0.0048
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0048	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0005	0.0003	0.0003
Brugia malayi	glutaminase DH11.1	0.033	0.3797	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0008	0.0048	0.0125
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0008	0.0048	0.0125
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0064	0.0197
Loa Loa (eye worm)	glutaminase	0.033	0.3797	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0064	0.0168
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0064	0.0168
Brugia malayi	Cathepsin L-like precursor	0.0008	0.0048	0.0125
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0048	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0008	0.0048	0.0126
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Brugia malayi	ecdysone receptor	0.0005	0.0003	0.0008
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0064	0.0168
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0048	0.0048
Brugia malayi	Smad1	0.001	0.0063	0.0167
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0064	0.0168
Brugia malayi	cathepsin L-like precursor	0.0008	0.0048	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0008
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0005	0.001	0.003
Brugia malayi	Papain family cysteine protease containing protein	0.0008	0.0048	0.0125
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0048	0.5
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0059	0.0155
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0064	0.0168
Echinococcus multilocularis	cysteine protease	0.0008	0.0048	0.0048
Echinococcus multilocularis	cathepsin b	0.0283	0.3242	0.3242
Brugia malayi	MH2 domain containing protein	0.001	0.0063	0.0167
Brugia malayi	nuclear receptor NHR-67	0.0005	0.0003	0.0008
Schistosoma mansoni	cpg binding protein	0.0031	0.0305	0.0803
Brugia malayi	ecdysteroid receptor	0.001	0.0064	0.0168
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0283	0.3242	0.854
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0008
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0005	0.0003	0.0009
Plasmodium falciparum	serine repeat antigen 3	0.0008	0.0048	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0841	0.2214
Brugia malayi	cathepsin L precursor	0.0008	0.0048	0.0125
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0841	0.084
Echinococcus multilocularis	cathepsin L cysteine protease	0.0008	0.0048	0.0048
Echinococcus granulosus	TGF beta signal transducer SmadC	0.001	0.0063	0.0195
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0064	0.0197
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0305	0.0803
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0064	0.0168
Plasmodium vivax	vivapain-2	0.0008	0.0048	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0048	0.0048
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0008	0.0048	0.0147
Onchocerca volvulus		0.0008	0.0048	0.1563
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0008
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0516	0.1359
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0516	0.1359
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0037	0.0098
Toxoplasma gondii	cathepsin B	0.0093	0.1036	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0008	0.0048	0.0125
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0064	0.0197
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0008	0.0048	0.0125
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0048	0.0048
Brugia malayi	cathepsin B-like cysteine proteinase	0.0283	0.3242	0.854
Echinococcus granulosus	smad	0.001	0.0063	0.0195
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0008	0.0048	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0064	0.0168
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0008	0.0048	0.0125
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0048	0.5
Brugia malayi	nuclear receptor RXR	0.0005	0.0003	0.0008
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0064	0.0168
Brugia malayi	MH1 domain containing protein	0.0005	0.0012	0.0032
Onchocerca volvulus	Cathepsin L homolog	0.0008	0.0048	0.1563
Loa Loa (eye worm)	nuclear hormone receptor	0.0005	0.0003	0.0008
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0064	0.0168
Brugia malayi	Cathepsin L-like precursor	0.0008	0.0048	0.0125
Schistosoma mansoni	smad	0.001	0.0063	0.0167
Brugia malayi	conserved hypotetical protein	0.0005	0.0003	0.0008
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0064	0.2093
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0008	0.0048	0.5
Echinococcus granulosus	cathepsin b	0.0283	0.3242	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0008	0.0048	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0048	0.0125
Brugia malayi	hypothetical protein	0.0005	0.0003	0.0008
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0048	0.0048
Brugia malayi	MH2 domain containing protein	0.001	0.0063	0.0167
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0005	0.0003	0.0003
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0008	0.0048	0.0126
Onchocerca volvulus		0.0008	0.0048	0.1563
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0008	0.0048	0.5
Loa Loa (eye worm)	Smad1	0.001	0.0063	0.0167
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0005	0.0003	0.0008
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0516	0.1359
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0008
Schistosoma mansoni	coup transcription factor	0.001	0.0064	0.0168
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0048	0.0048
Schistosoma mansoni	Smad4	0.001	0.0063	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0048	0.0125
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0008	0.0048	0.5
Loa Loa (eye worm)	MH1 domain-containing protein	0.001	0.0063	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0008
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0048	0.5
Echinococcus multilocularis	Smad4	0.001	0.0063	0.0063
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0093	0.1036	0.2728
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0005	0.0003	0.0009
Loa Loa (eye worm)	glutaminase 2	0.033	0.3797	1
Brugia malayi	Papain family cysteine protease containing protein	0.0008	0.0048	0.0125
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0008	0.0048	0.0126
Brugia malayi	nuclear receptor NHR-88	0.0005	0.0003	0.0008
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0064	0.0168
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0064	0.0168
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0048	0.5
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0005	0.0003	0.0008
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0048	0.5
Echinococcus granulosus	cpg binding protein	0.0032	0.0325	0.1003
Loa Loa (eye worm)	hypothetical protein	0.001	0.0064	0.0168
Echinococcus multilocularis	cathepsin L cysteine protease	0.0008	0.0048	0.0048
Brugia malayi	Nuclear hormone receptor E75	0.0005	0.0003	0.0008
Loa Loa (eye worm)	MH2 domain-containing protein	0.001	0.0063	0.0167
Loa Loa (eye worm)	cathepsin B	0.0093	0.1036	0.2728
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0008	0.0048	0.0048
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0064	0.2093
Brugia malayi	Cathepsin L-like precursor	0.0008	0.0048	0.0125
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0048	0.5
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0037	0.0037
Onchocerca volvulus		0.0008	0.0048	0.1563
Echinococcus granulosus	cathepsin b	0.0283	0.3242	1
Onchocerca volvulus		0.0031	0.0305	1
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.001	0.0064	0.0168
Brugia malayi	Cathepsin L-like precursor	0.0008	0.0048	0.0125
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0058	0.0152
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0048	0.5
Plasmodium vivax	serine-repeat antigen (SERA)	0.0008	0.0048	0.5
Plasmodium vivax	vivapain-2	0.0008	0.0048	0.5
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.001	0.0063	0.0063
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0283	0.3242	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0003	0.0008
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0064	0.0168
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0008	0.0048	0.5
Loa Loa (eye worm)	hypothetical protein	0.0283	0.3242	0.854
Loa Loa (eye worm)	fibroinase	0.0008	0.0048	0.0125
Brugia malayi	nuclear hormone receptor family member odr-7	0.0005	0.0003	0.0008
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0048	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0048	0.0048
Plasmodium falciparum	serine repeat antigen 8	0.0008	0.0048	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0008	0.0048	0.0048
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0048	0.5
Schistosoma mansoni	cpg binding protein	0.0032	0.0325	0.0857
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0048	0.0048

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	26.6795 uM	PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	70.7946 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1900826

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1551862