Detailed information for compound 1553182

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 435.515 | Formula: C25H29N3O4
  • H donors: 3 H acceptors: 3 LogP: 4.15 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H]([C@@H](CC)C)NC(=O)OCc1ccccc1
  • InChi: 1S/C25H29N3O4/c1-3-17(2)23(28-25(31)32-16-18-9-5-4-6-10-18)24(30)27-20(15-29)13-19-14-26-22-12-8-7-11-21(19)22/h4-12,14-15,17,20,23,26H,3,13,16H2,1-2H3,(H,27,30)(H,28,31)/t17-,20-,23+/m1/s1
  • InChiKey: BUXZFLJETAQWPU-LLBVYWAGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0103 0.2406 0.5489
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0599 0.4419
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0599 0.4419
Entamoeba histolytica cysteine protease, putative 0.0019 0.0264 0.1968
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.001 0.0036 0.0027
Echinococcus multilocularis Immunoglobulin 0.0085 0.196 0.1958
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0599 0.4419
Schistosoma mansoni cpg binding protein 0.003 0.0539 0.0531
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0176 0.0402
Brugia malayi Cathepsin L-like precursor 0.0023 0.037 0.0845
Brugia malayi hypothetical protein 0.018 0.4385 1
Trypanosoma cruzi cysteine protease, putative 0.0019 0.0264 0.0615
Brugia malayi cathepsin L precursor 0.001 0.0036 0.0081
Loa Loa (eye worm) hypothetical protein 0.0103 0.2406 0.5789
Plasmodium falciparum cysteine proteinase falcipain 3 0.0032 0.0599 1
Plasmodium vivax vivapain-2 0.0032 0.0599 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0047 0.0992 0.2262
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.001 0.0036 0.0451
Echinococcus granulosus cathepsin L cysteine protease 0.0019 0.0264 0.0261
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0055 0.1195 0.1187
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0176 0.0416
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0599 0.4419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0599 0.373
Loa Loa (eye worm) cysteine protease 0.0032 0.0599 0.1435
Loa Loa (eye worm) hypothetical protein 0.0055 0.1195 0.2872
Loa Loa (eye worm) hypothetical protein 0.0055 0.1195 0.2872
Plasmodium vivax serine-repeat antigen (SERA) 0.001 0.0036 0.0451
Onchocerca volvulus Cathepsin L homolog 0.0032 0.0599 0.2375
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.001 0.0036 0.0451
Onchocerca volvulus 0.0032 0.0599 0.2375
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0103 0.2406 0.24
Leishmania major cathepsin L-like protease 0.0032 0.0599 0.373
Brugia malayi Cathepsin L-like precursor 0.0032 0.0599 0.1365
Entamoeba histolytica cysteine protease, putative 0.0019 0.0264 0.1968
Brugia malayi Cathepsin L-like precursor 0.0032 0.0599 0.1365
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0103 0.2406 0.5489
Brugia malayi hypothetical protein 0.0085 0.196 0.447
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0032 0.0599 1
Echinococcus multilocularis cysteine protease 0.0032 0.0599 0.0596
Trypanosoma cruzi cysteine proteinase, putative 0.0019 0.0264 0.0615
Loa Loa (eye worm) hypothetical protein 0.0103 0.2406 0.5789
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0176 0.0402
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0176 0.0173
Echinococcus granulosus glycine receptor subunit alpha 1 0.0103 0.2406 0.2404
Onchocerca volvulus 0.0103 0.2406 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0055 0.1195 0.1187
Schistosoma mansoni cell adhesion molecule 0.0085 0.196 0.1953
Schistosoma mansoni acetylcholine receptor subunit beta 0.0047 0.0992 0.0984
Brugia malayi cathepsin Z-like cysteine proteinase 0.001 0.0036 0.0081
Loa Loa (eye worm) hypothetical protein 0.0103 0.2406 0.5789
Onchocerca volvulus 0.0103 0.2406 1
Echinococcus granulosus cpg binding protein 0.003 0.0539 0.0537
Brugia malayi cathepsin B-like cysteine proteinase 0.0171 0.4155 0.9476
Brugia malayi Fibronectin type III domain containing protein 0.0085 0.196 0.447
Plasmodium vivax serine-repeat antigen (SERA) 0.001 0.0036 0.0451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0599 0.4419
Giardia lamblia Cathepsin B precursor 0.006 0.131 1
Echinococcus granulosus cathepsin L 0.0019 0.0264 0.0261
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.001 0.0036 0.0451
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0176 0.0173
Plasmodium vivax unspecified product 0.001 0.0036 0.0451
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0015
Loa Loa (eye worm) hypothetical protein 0.0055 0.1195 0.2872
Onchocerca volvulus 0.0055 0.1195 0.4891
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0599 0.373
Brugia malayi cathepsin Z-like cysteine proteinase 0.001 0.0036 0.0081
Giardia lamblia Cathepsin B precursor 0.006 0.131 1
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0264 0.1968
Plasmodium vivax unspecified product 0.0019 0.0264 0.4322
Echinococcus granulosus contactin 0.008 0.1839 0.1836
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0099 0.2327 0.5597
Echinococcus granulosus cathepsin l1 0.0032 0.0599 0.0596
Leishmania major cathepsin L-like protease 0.0032 0.0599 0.373
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0085 0.196 0.1958
Schistosoma mansoni titin 0.008 0.1839 0.1831
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0176 0.5
Echinococcus granulosus glycine receptor subunit alpha 1 0.0103 0.2406 0.2404
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0055 0.1195 0.2726
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.037 0.0362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0599 0.4419
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0176 0.0167
Onchocerca volvulus 0.0103 0.2406 1
Brugia malayi Cathepsin L-like precursor 0.0023 0.037 0.0845
Echinococcus granulosus neuroglian 0.0085 0.196 0.1958
Plasmodium falciparum cysteine proteinase falcipain 1 0.0019 0.0264 0.4054
Loa Loa (eye worm) hypothetical protein 0.0085 0.196 0.4714
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0264 0.0615
Plasmodium vivax vivapain-3 0.0019 0.0264 0.4322
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.001 0.0036 0.0027
Loa Loa (eye worm) hypothetical protein 0.0047 0.0992 0.2382
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0085 0.196 0.1958
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.037 0.2886
Onchocerca volvulus 0.0032 0.0599 0.2375
Entamoeba histolytica cysteine protease, putative 0.0019 0.0264 0.1968
Entamoeba histolytica cysteine protease, putative 0.0019 0.0264 0.1968
Leishmania major cathepsin L-like protease 0.0032 0.0599 0.373
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.037 0.2627
Echinococcus multilocularis cpg binding protein 0.003 0.0539 0.0537
Loa Loa (eye worm) LGC-31 protein 0.0103 0.2406 0.5789
Brugia malayi Cathepsin L-like precursor 0.0032 0.0599 0.1365
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0103 0.2406 0.5489
Schistosoma mansoni nAChR subunit 0.0103 0.2406 0.24
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0103 0.2406 0.5789
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0103 0.2406 0.5789
Loa Loa (eye worm) hypothetical protein 0.0047 0.0992 0.2382
Echinococcus granulosus irregular chiasm roughest protein 0.0099 0.2327 0.2325
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0599 0.373
Entamoeba histolytica cysteine protease, putative 0.0019 0.0264 0.1968
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.001 0.0036 0.0079
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0264 0.1968
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0103 0.2406 0.2404
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0171 0.4155 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0032 0.0599 0.4419
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.001 0.0036 0.0451
Entamoeba histolytica cysteine proteinase 1, putative 0.0019 0.0264 0.1968
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0103 0.2406 0.2404
Loa Loa (eye worm) hypothetical protein 0.0165 0.4018 0.967
Leishmania major cathepsin L-like protease 0.0032 0.0599 0.373
Echinococcus multilocularis conserved hypothetical protein 0.0099 0.2327 0.2325
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1303 0.1295
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0103 0.2406 0.5489
Loa Loa (eye worm) ACC-1 protein 0.0103 0.2406 0.5789
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0103 0.2406 0.2404
Onchocerca volvulus 0.0032 0.0599 0.2375
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0103 0.2406 0.5489
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.4155 0.415
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0599 0.4419
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0176 0.0173
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0176 0.0173
Brugia malayi Cathepsin L-like precursor 0.0032 0.0599 0.1365
Loa Loa (eye worm) hypothetical protein 0.0085 0.196 0.4714
Echinococcus multilocularis Immunoglobulin 0.0185 0.4506 0.4504
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.001 0.0036 0.0027
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.114 0.867
Schistosoma mansoni cathepsin C 0.001 0.0036 0.0027
Loa Loa (eye worm) hypothetical protein 0.0103 0.2406 0.5789
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0055 0.1195 0.2726
Loa Loa (eye worm) hypothetical protein 0.0085 0.196 0.4714
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0599 0.373
Schistosoma mansoni nAChR subunit 0.0047 0.0992 0.0984
Loa Loa (eye worm) hypothetical protein 0.0047 0.0992 0.2382
Schistosoma mansoni cpg binding protein 0.0028 0.0498 0.049
Schistosoma mansoni hypothetical protein 0.0099 0.2327 0.232
Schistosoma mansoni cathepsin B (C01 family) 0.001 0.0036 0.0027
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.4155 0.415
Leishmania major cathepsin L-like protease 0.0032 0.0599 0.373
Onchocerca volvulus Netrin receptor homolog 0.008 0.1839 0.7605
Plasmodium vivax serine-repeat antigen (SERA), putative 0.001 0.0036 0.0451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0599 0.373
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0023 0.037 0.0871
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0103 0.2406 0.5489
Echinococcus multilocularis hemicentin 1 0.008 0.1839 0.1836
Onchocerca volvulus Putative titin 0.008 0.1839 0.7605
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.001 0.0036 0.0027
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.001 0.0036 0.0027
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0103 0.2406 0.2404
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0599 0.1365
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0032 0.0599 0.0596
Loa Loa (eye worm) papain family cysteine protease containing protein 0.001 0.0036 0.0079
Loa Loa (eye worm) hypothetical protein 0.0103 0.2406 0.5789
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0599 0.4419
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0599 0.4419
Brugia malayi Immunoglobulin I-set domain containing protein 0.0099 0.2327 0.5307
Echinococcus granulosus twitchin 0.0085 0.196 0.1958
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0103 0.2406 0.2404
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0009 0.0009 0.0015
Loa Loa (eye worm) hypothetical protein 0.0055 0.1195 0.2872
Loa Loa (eye worm) hypothetical protein 0.0055 0.1195 0.2872
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0103 0.2406 0.2404
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0079
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0103 0.2406 0.5489
Echinococcus multilocularis glycine receptor subunit beta 0.0103 0.2406 0.2404
Onchocerca volvulus Cathepsin F homolog 0.0032 0.0599 0.2375
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0599 0.4854
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.0599 0.059
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0264 0.1968
Trypanosoma cruzi major cysteine proteinase, putative 0.001 0.0036 0.0064
Echinococcus granulosus cathepsin L cysteine proteinase 0.0032 0.0599 0.0596
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.001 0.0036 0.0451
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0176 0.2486
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0103 0.2406 0.5489
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.037 0.2627
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.008 0.1839 0.1836
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0079
Echinococcus granulosus roundabout 2 0.0085 0.196 0.1958
Loa Loa (eye worm) hypothetical protein 0.0055 0.1195 0.2872
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0047 0.0992 0.0989
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0264 0.1791
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0498 0.1193
Entamoeba histolytica cysteine protease, putative 0.0019 0.0264 0.1968
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0599 0.1422
Entamoeba histolytica cysteine protease, putative 0.0019 0.0264 0.1968
Loa Loa (eye worm) hypothetical protein 0.0047 0.0992 0.2382
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0599 0.4419
Loa Loa (eye worm) hypothetical protein 0.0103 0.2406 0.5789
Loa Loa (eye worm) hypothetical protein 0.0103 0.2406 0.5789
Brugia malayi Immunoglobulin I-set domain containing protein 0.0099 0.2327 0.5307
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0009 0.0009 0.0021
Brugia malayi cathepsin L-like precursor 0.0023 0.037 0.0845
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0036 0.0081
Loa Loa (eye worm) hypothetical protein 0.0055 0.1195 0.2872
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0599 0.4419
Onchocerca volvulus 0.0028 0.0498 0.1952
Brugia malayi cathepsin F-like cysteine proteinase 0.001 0.0036 0.0081
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0264 0.1968
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0103 0.2406 0.24
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.006 0.131 0.1302
Echinococcus multilocularis cathepsin L cysteine protease 0.0032 0.0599 0.0596
Loa Loa (eye worm) hypothetical protein 0.0047 0.0992 0.2382
Echinococcus granulosus glycine receptor subunit alpha 1 0.0103 0.2406 0.2404
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0103 0.2406 0.5489
Plasmodium vivax serine-repeat antigen (SERA), putative 0.001 0.0036 0.0451
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0103 0.2406 0.2404
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0599 0.373
Brugia malayi cathepsin L-like cysteine proteinase 0.001 0.0036 0.0081
Entamoeba histolytica cysteine protease, putative 0.0032 0.0599 0.4854
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0055 0.1195 0.2726
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0015
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.001 0.0036 0.0451
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0055 0.1195 0.1187
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.037 0.0845
Onchocerca volvulus Tyrosine kinase homolog 0.008 0.1839 0.7605
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0047 0.0992 0.0989
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0264 0.0255
Schistosoma mansoni cpg binding protein 0.003 0.0539 0.0531
Loa Loa (eye worm) hypothetical protein 0.0055 0.1195 0.2872
Echinococcus multilocularis geminin 0.0165 0.4014 0.4013
Schistosoma mansoni nAChR subunit 0.0103 0.2406 0.24
Brugia malayi hypothetical protein 0.0047 0.0992 0.2262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0599 0.4419
Echinococcus multilocularis nephrin 0.0099 0.2327 0.2325
Entamoeba histolytica cysteine protease, putative 0.0019 0.0264 0.1968
Onchocerca volvulus Basement membrane proteoglycan homolog 0.008 0.1839 0.7605
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0599 0.4419
Onchocerca volvulus 0.0055 0.1195 0.4891
Schistosoma mansoni neurotransmitter gated ion channel 0.0047 0.0992 0.0984
Loa Loa (eye worm) cathepsin B 0.006 0.131 0.3147
Echinococcus multilocularis cathepsin b 0.0171 0.4155 0.4153
Loa Loa (eye worm) hypothetical protein 0.0047 0.0992 0.2382
Schistosoma mansoni neurotransmitter gated ion channel 0.0047 0.0992 0.0984
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0103 0.2406 0.24
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0599 0.4419
Brugia malayi Cathepsin L-like precursor 0.0032 0.0599 0.1365
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0599 0.4419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0599 0.373
Onchocerca volvulus 0.008 0.1839 0.7605
Loa Loa (eye worm) hypothetical protein 0.0171 0.4155 1
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0085 0.196 0.1953
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0103 0.2406 0.5489
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0264 0.0602
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0599 0.4419
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.4155 0.415
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.006 0.131 1
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0047 0.0992 0.2262
Loa Loa (eye worm) hypothetical protein 0.0085 0.196 0.4714
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0103 0.2406 0.2404
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0085 0.196 0.1953
Loa Loa (eye worm) hypothetical protein 0.0103 0.2406 0.5789
Loa Loa (eye worm) hypothetical protein 0.0085 0.196 0.4714
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0047 0.0992 0.0989
Echinococcus granulosus glycine receptor subunit beta 0.0103 0.2406 0.2404
Trypanosoma cruzi cysteine proteinase, putative 0.0019 0.0264 0.0615
Echinococcus multilocularis irregular chiasm roughest protein immunoglobulin set domain containing protein 0.0099 0.2327 0.2325
Leishmania major cysteine peptidase A (CPA) 0.0032 0.0599 0.373
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0599 0.4419
Loa Loa (eye worm) hypothetical protein 0.0047 0.0992 0.2382
Loa Loa (eye worm) hypothetical protein 0.0103 0.2406 0.5789
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.0264 0.0779
Loa Loa (eye worm) hypothetical protein 0.0103 0.2406 0.5789
Echinococcus granulosus cathepsin l cysteine peptidase 0.0032 0.0599 0.0596
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.001 0.0036 0.0027
Schistosoma mansoni cathepsin S (C01 family) 0.001 0.0036 0.0027
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0599 0.1422
Echinococcus granulosus cathepsin b 0.0171 0.4155 0.4153
Echinococcus granulosus cathepsin l1 0.0023 0.037 0.0368
Echinococcus granulosus cathepsin L 0.001 0.0036 0.0033
Toxoplasma gondii cathepsin CPL 0.0032 0.0599 0.4419
Schistosoma mansoni nAChR subunit 0.0103 0.2406 0.24
Onchocerca volvulus 0.0103 0.2406 1
Plasmodium vivax vivapain-2 0.0032 0.0599 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0599 0.4419
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0036 0.0081
Schistosoma mansoni nAChR subunit 0.0047 0.0992 0.0984
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0176 0.0173
Echinococcus multilocularis neuroglian 0.0085 0.196 0.1958
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0103 0.2406 0.5789
Entamoeba histolytica cysteine protease, putative 0.0019 0.0264 0.1968
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.001 0.0036 0.0027
Onchocerca volvulus 0.008 0.1839 0.7605
Schistosoma mansoni nAChR subunit 0.0103 0.2406 0.24
Loa Loa (eye worm) hypothetical protein 0.0047 0.0992 0.2382
Schistosoma mansoni nAChR subunit 0.0103 0.2406 0.24
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.0264 0.0779
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0103 0.2406 0.2404
Brugia malayi hypothetical protein 0.0047 0.0992 0.2262
Loa Loa (eye worm) GABA receptor subunit 0.0055 0.1195 0.2872
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0176 0.1098
Echinococcus granulosus geminin 0.0165 0.4014 0.4013
Loa Loa (eye worm) hypothetical protein 0.0047 0.0992 0.2382
Echinococcus multilocularis cysteine protease 0.0032 0.0599 0.0596
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0103 0.2406 0.2404
Loa Loa (eye worm) hypothetical protein 0.0032 0.0599 0.1435
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0019 0.0264 0.0615
Onchocerca volvulus 0.0047 0.0992 0.4034
Brugia malayi Immunoglobulin I-set domain containing protein 0.0085 0.196 0.447
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0103 0.2406 0.5489
Loa Loa (eye worm) papain family cysteine protease containing protein 0.001 0.0036 0.0079
Onchocerca volvulus 0.0047 0.0992 0.4034
Echinococcus multilocularis cathepsin L cysteine protease 0.0032 0.0599 0.0596
Plasmodium vivax vivapain-1 0.0019 0.0264 0.4322
Schistosoma mansoni vesicular amine transporter 0.0085 0.196 0.1953
Onchocerca volvulus 0.0032 0.0599 0.2375
Trypanosoma cruzi major cysteine proteinase, putative 0.001 0.0036 0.0064
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0103 0.2406 0.5489
Entamoeba histolytica cysteine protease, putative 0.0019 0.0264 0.1968
Brugia malayi hypothetical protein 0.0047 0.0992 0.2262
Leishmania major cathepsin L-like protease 0.0032 0.0599 0.373
Giardia lamblia Cathepsin B precursor 0.006 0.131 1
Entamoeba histolytica cysteine proteinase 2 0.0019 0.0264 0.1968
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0103 0.2406 0.5489
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0599 0.4854
Schistosoma mansoni acetylcholine receptor-related 0.0047 0.0992 0.0984
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0103 0.2406 0.2404
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0047 0.0992 0.2262
Echinococcus multilocularis cathepsin L 0.001 0.0036 0.0033
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0599 0.1422
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0103 0.2406 0.5489
Loa Loa (eye worm) hypothetical protein 0.0047 0.0992 0.2382
Loa Loa (eye worm) hypothetical protein 0.0103 0.2406 0.5789
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0171 0.4155 0.415
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0103 0.2406 0.2404
Onchocerca volvulus 0.008 0.1839 0.7605
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0032 0.0599 0.1435
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0103 0.2406 0.24
Trypanosoma brucei cysteine peptidase C (CPC) 0.006 0.131 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0103 0.2406 0.5489
Brugia malayi cathepsin F-like cysteine proteinase 0.0009 0.0009 0.0021
Loa Loa (eye worm) hypothetical protein 0.0047 0.0992 0.2382
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0599 0.4419
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0047 0.0992 0.2262
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0103 0.2406 0.2404
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0103 0.2406 0.2404
Echinococcus granulosus hemicentin 1 0.008 0.1839 0.1836
Onchocerca volvulus 0.0032 0.0599 0.2375
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.001 0.0036 0.0027
Schistosoma mansoni nAChR subunit 0.0103 0.2406 0.24
Loa Loa (eye worm) hypothetical protein 0.0103 0.2406 0.5789
Entamoeba histolytica cysteine protease, putative 0.0019 0.0264 0.1968
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0599 0.373
Echinococcus granulosus cathepsin b 0.0171 0.4155 0.4153
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.001 0.0036 0.0027
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0599 0.1422
Loa Loa (eye worm) ACC-1 protein 0.0103 0.2406 0.5789
Brugia malayi Cation transporter family protein 0.0103 0.2406 0.5489
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0047 0.0992 0.2382
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0264 0.0255
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0099 0.2327 0.5597
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0103 0.2406 0.2404
Schistosoma mansoni hypothetical protein 0.0165 0.4014 0.4009
Echinococcus granulosus Immunoglobulin 0.0085 0.196 0.1958
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0032 0.0599 0.1435
Echinococcus granulosus defective proboscis extension response 0.0085 0.196 0.1958
Loa Loa (eye worm) ctsf protein 0.0032 0.0599 0.1435
Loa Loa (eye worm) hypothetical protein 0.0103 0.2406 0.5789
Echinococcus multilocularis cathepsin L 0.0019 0.0264 0.0261
Loa Loa (eye worm) hypothetical protein 0.0009 0.0009 0.0015
Echinococcus granulosus low density lipoprotein receptor ldl 0.008 0.1839 0.1836
Brugia malayi Immunoglobulin I-set domain containing protein 0.0085 0.196 0.447
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0599 0.373
Brugia malayi hypothetical protein 0.0047 0.0992 0.2262
Leishmania major cathepsin L-like protease 0.0032 0.0599 0.373
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0264 0.0602
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0176 0.2824
Schistosoma mansoni nephrin 0.0085 0.196 0.1953
Loa Loa (eye worm) hypothetical protein 0.0085 0.196 0.4714
Brugia malayi Cathepsin L-like precursor 0.0032 0.0599 0.1365
Loa Loa (eye worm) hypothetical protein 0.0085 0.196 0.4714
Brugia malayi cahepsin L-like non-peptiedase homolog 0.001 0.0036 0.0081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0599 0.4419
Entamoeba histolytica cysteine protease, putative 0.0019 0.0264 0.1968
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.0599 0.059
Echinococcus multilocularis dnaJ subfamily B 0.0399 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0032 0.0599 0.0596
Onchocerca volvulus 0.0103 0.2406 1
Schistosoma mansoni hypothetical protein 0.0399 1 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.2406 0.5789
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0047 0.0992 0.2262
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.006 0.131 0.3137
Schistosoma mansoni hypothetical protein 0.008 0.1839 0.1831
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.001 0.0036 0.0451
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0176 0.1098
Brugia malayi hypothetical protein 0.0047 0.0992 0.2262
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0599 0.4419
Echinococcus granulosus nAChR subunit 0.0055 0.1195 0.1193
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0599 0.4419
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0103 0.2406 0.5789
Loa Loa (eye worm) hypothetical protein 0.0047 0.0992 0.2382
Echinococcus granulosus cysteine protease 0.0019 0.0264 0.0261
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0079
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0103 0.2406 0.24
Brugia malayi excitatory GABA receptor EXP-1A 0.0103 0.2406 0.5489
Schistosoma mansoni hypothetical protein 0.0165 0.4014 0.4009
Entamoeba histolytica hypothetical protein 0.0055 0.1195 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0085 0.196 0.4714
Loa Loa (eye worm) hypothetical protein 0.0085 0.196 0.4714
Schistosoma mansoni hypothetical protein 0.0099 0.2327 0.232
Brugia malayi isocitrate dehydrogenase 0.0015 0.0176 0.04
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0079
Loa Loa (eye worm) hypothetical protein 0.0055 0.1195 0.2872
Echinococcus multilocularis glycine receptor subunit beta 0.0103 0.2406 0.2404
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0599 0.373
Echinococcus multilocularis nAChR subunit 0.0055 0.1195 0.1193
Loa Loa (eye worm) hypothetical protein 0.0103 0.2406 0.5789
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0103 0.2406 0.24
Loa Loa (eye worm) hypothetical protein 0.0103 0.2406 0.5789
Loa Loa (eye worm) hypothetical protein 0.0103 0.2406 0.5789
Echinococcus granulosus glycine receptor subunit beta 0.0103 0.2406 0.2404
Brugia malayi Cation transporter family protein 0.0103 0.2406 0.5489
Echinococcus multilocularis nAChR subunit 0.0103 0.2406 0.2404
Onchocerca volvulus 0.0103 0.2406 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0992 0.2382
Onchocerca volvulus Cathepsin L homolog 0.0032 0.0599 0.2375
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0103 0.2406 0.2404
Loa Loa (eye worm) hypothetical protein 0.0047 0.0992 0.2382
Loa Loa (eye worm) hypothetical protein 0.0023 0.037 0.0885
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0176 0.04
Entamoeba histolytica cysteine protease, putative 0.0019 0.0264 0.1968
Echinococcus granulosus Immunoglobulin 0.0099 0.2327 0.2325
Echinococcus granulosus nephrin 0.0099 0.2327 0.2325
Loa Loa (eye worm) fibroinase 0.0032 0.0599 0.1435
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.001 0.0036 0.0451
Loa Loa (eye worm) acetylcholine receptor protein 0.0047 0.0992 0.2382
Onchocerca volvulus Putative nachr subunit 0.0103 0.2406 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0103 0.2406 0.5789
Loa Loa (eye worm) hypothetical protein 0.0047 0.0992 0.2382
Onchocerca volvulus 0.0023 0.037 0.1412
Leishmania major cathepsin L-like protease 0.0032 0.0599 0.373
Onchocerca volvulus 0.0047 0.0992 0.4034
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0103 0.2406 0.2404
Brugia malayi CXXC zinc finger family protein 0.0028 0.0498 0.1137
Brugia malayi Cation transporter family protein 0.0103 0.2406 0.5489
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.006 0.131 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0599 0.4419
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0032 0.0599 1
Brugia malayi fibroinase precursor 0.001 0.0036 0.0081
Loa Loa (eye worm) hypothetical protein 0.0023 0.037 0.0885
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0047 0.0992 0.0989
Onchocerca volvulus 0.0032 0.0599 0.2375
Echinococcus multilocularis roundabout 2 0.0085 0.196 0.1958
Echinococcus granulosus nephrin 0.0099 0.2327 0.2325
Trypanosoma cruzi cruzipain precursor, putative 0.0032 0.0599 0.1422
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0047 0.0992 0.0989
Toxoplasma gondii cathepsin B 0.006 0.131 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0176 0.0173
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0264 0.0255
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0103 0.2406 0.5489
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0103 0.2406 0.5789
Onchocerca volvulus 0.0032 0.0599 0.2375
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0055 0.1195 0.2726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0264 0.1791
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0079
Loa Loa (eye worm) hypothetical protein 0.0103 0.2406 0.5789
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0079
Echinococcus granulosus nAChR subunit 0.0103 0.2406 0.2404
Echinococcus multilocularis cathepsin b 0.0171 0.4155 0.4153
Loa Loa (eye worm) hypothetical protein 0.0103 0.2406 0.5789
Schistosoma mansoni nAChR subunit 0.0103 0.2406 0.24
Brugia malayi Cathepsin L-like precursor 0.0009 0.0009 0.0021
Onchocerca volvulus 0.008 0.1839 0.7605
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.008 0.1839 0.1831
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0032 0.0599 0.4419
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0103 0.2406 0.2404
Loa Loa (eye worm) hypothetical protein 0.0023 0.037 0.0885
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0599 0.373
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0036 0.0081
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0047 0.0992 0.2382
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0047 0.0992 0.2262

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.1 nM Inhibition of human cathepsin L. ChEMBL. 9784105
IC50 (binding) = 530 nM Inhibition of human cathepsin B ChEMBL. 9784105

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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