Detailed information for compound 1558471

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 379.838 | Formula: C18H22ClN3O4
  • H donors: 1 H acceptors: 3 LogP: 4.44 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC(COC(=O)c1cc(ccc1Cl)n1ncc(=O)[nH]c1=O)CC
  • InChi: 1S/C18H22ClN3O4/c1-3-5-6-12(4-2)11-26-17(24)14-9-13(7-8-15(14)19)22-18(25)21-16(23)10-20-22/h7-10,12H,3-6,11H2,1-2H3,(H,21,23,25)
  • InChiKey: FIVQGVHQWJXOKD-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.011 0.2288 0.9992
Loa Loa (eye worm) hypothetical protein 0.0033 0.0624 0.2363
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.5094 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0052 0.01
Trypanosoma brucei glucose transporter, putative 0.0034 0.0648 0.2738
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0902 0.3939
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0494 0.1861
Entamoeba histolytica hypothetical protein 0.0036 0.0698 0.2911
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0902 0.3437
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0442 0.1824
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0052 0.01
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0442 0.1928
Echinococcus multilocularis GPCR, family 2 0.0015 0.0242 0.0879
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0245 0.0956
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.229 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1224 0.5285
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0065 0.0091
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0722 0.3066
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Toxoplasma gondii facilitative glucose transporter GT1 0.011 0.2288 0.3424
Echinococcus granulosus lamin 0.0027 0.0494 0.2001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0242 0.0887
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0648 0.2738
Echinococcus granulosus GPCR family 2 0.0015 0.0242 0.0879
Leishmania major glucose transporter, lmgt2 0.0034 0.0648 0.2738
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0245 0.0956
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0242 0.0887
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0318 0.1179
Brugia malayi hypothetical protein 0.0015 0.0245 0.09
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0648 0.2738
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0242 0.0887
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0006 0.0045 0.0125
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0626 0.2371
Toxoplasma gondii sugar transporter ST3 0.0015 0.0245 0.0327
Toxoplasma gondii exonuclease III APE 0.0019 0.0318 0.0437
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0722 0.3066
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.2601 1
Schistosoma mansoni protein kinase 0.0034 0.0639 0.279
Trypanosoma cruzi hexose transporter 0.0034 0.0648 0.2738
Mycobacterium ulcerans beta-lactamase 0.0038 0.0722 0.3066
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0318 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0178 0.3752 0.3724
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0094 0.0316
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0722 0.2742
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0242 0.0879
Mycobacterium ulcerans sugar transporter 0.0015 0.0245 0.0956
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0006 0.0045 0.0069
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0034 0.0639 0.242
Schistosoma mansoni smad1 5 8 and 0.0008 0.0094 0.0411
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0223 0.0815
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0094 0.0316
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0902 0.3437
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0245 0.0956
Brugia malayi Sugar transporter family protein 0.0015 0.0245 0.09
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0722 0.3154
Leishmania major glucose transporter, lmgt3 0.0034 0.0648 0.2738
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0318 0.1276
Leishmania major hypothetical protein, conserved 0.0038 0.0722 0.3066
Loa Loa (eye worm) hypothetical protein 0.0033 0.0626 0.2371
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Loa Loa (eye worm) hypothetical protein 0.0025 0.0442 0.1658
Leishmania major glucose transporter/membrane transporter D2, putative 0.0034 0.0648 0.2738
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0648 0.2738
Leishmania major hypothetical protein, conserved 0.0015 0.0245 0.0956
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0624 0.2725
Echinococcus granulosus cpg binding protein 0.003 0.0567 0.2328
Loa Loa (eye worm) hypothetical protein 0.0015 0.0245 0.09
Schistosoma mansoni hypothetical protein 0.0036 0.0698 0.305
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0204 0.0739
Toxoplasma gondii sugar transporter ST2 0.0015 0.0245 0.0327
Trypanosoma brucei glucose transporter, putative 0.0034 0.0648 0.2738
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.2288 0.9992
Plasmodium falciparum calcium-dependent protein kinase 1 0.0034 0.0639 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0034 0.0639 0.0597
Leishmania major glucose transporter, lmgt1 0.0034 0.0648 0.2738
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0957 0.365
Schistosoma mansoni smad 0.0008 0.0094 0.0411
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0554 0.0795
Entamoeba histolytica protein kinase, putative 0.0034 0.0639 0.2646
Plasmodium vivax calcium-dependent protein kinase, putative 0.0034 0.0639 0.0597
Leishmania major ATP-dependent phosphofructokinase 0.011 0.229 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0554 0.0511
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Loa Loa (eye worm) sugar transporter 0.011 0.2288 0.8791
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0362 0.0656
Loa Loa (eye worm) hypothetical protein 0.0034 0.0639 0.242
Plasmodium vivax CDK-related protein kinase 6, putative 0.0467 1 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0065 0.0091
Schistosoma mansoni sugar transporter 0.0015 0.0245 0.1071
Loa Loa (eye worm) hypothetical protein 0.0038 0.0722 0.2742
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0103 0.026
Loa Loa (eye worm) hypothetical protein 0.0015 0.0245 0.09
Schistosoma mansoni cpg binding protein 0.003 0.0567 0.2477
Echinococcus multilocularis solute carrier family 22 0.0015 0.0245 0.0893
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0554 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0103 0.0351
Schistosoma mansoni lamin 0.0027 0.0494 0.2157
Loa Loa (eye worm) hypothetical protein 0.0013 0.0182 0.0654
Brugia malayi hypothetical protein 0.0036 0.0698 0.265
Brugia malayi Smad1 0.0008 0.0094 0.0316
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0033 0.0624 0.2632
Loa Loa (eye worm) hypothetical protein 0.0015 0.0245 0.09
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0554 0.2267
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0648 0.2738
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.229 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0245 0.09
Brugia malayi Cam kinase protein 1 0.0034 0.0639 0.242
Brugia malayi glycyl-tRNA synthetase 0.0006 0.0045 0.0125
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0554 0.232
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0902 0.3939
Giardia lamblia Lysyl-tRNA synthetase 0.0025 0.0442 0.6849
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0245 0.09
Entamoeba histolytica hypothetical protein 0.0025 0.0442 0.1768
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.229 0.8798
Echinococcus granulosus 6 phosphofructokinase 0.011 0.229 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Loa Loa (eye worm) hypothetical protein 0.0015 0.0242 0.0887
Brugia malayi beta-lactamase 0.0038 0.0722 0.2742
Plasmodium falciparum proline--tRNA ligase 0.0038 0.0742 0.0701
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0442 0.1824
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0034 0.0639 0.2646
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0245 0.09
Echinococcus multilocularis musashi 0.0027 0.0494 0.2001
Mycobacterium tuberculosis Conserved protein 0.0038 0.0722 0.1368
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0722 0.1368
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0722 0.2742
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0902 0.3939
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0034 0.0639 0.2697
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0065 0.0285
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0025 0.0442 0.1824
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0033 0.0624 0.2581
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0242 0.0879
Schistosoma mansoni sugar transporter 0.0015 0.0245 0.1071
Onchocerca volvulus 0.0038 0.0722 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0245 0.0956
Schistosoma mansoni hypothetical protein 0.0015 0.0242 0.1057
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.229 1
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0245 0.0201
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0532 0.2007
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0245 0.0327
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0554 0.8784
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0442 0.1824
Echinococcus multilocularis Smad4 0.0008 0.0094 0.0221
Brugia malayi major facilitator superfamily protein 0.0015 0.0245 0.09
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.229 1
Onchocerca volvulus 0.0027 0.0494 0.5217
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0639 0.2646
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0052 0.01
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0318 0.1216
Echinococcus multilocularis smad 0.0008 0.0094 0.0221
Brugia malayi 6-phosphofructokinase 0.011 0.229 0.8798
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0318 0.1276
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1087 0.1604
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.2601 1
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.229 1
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0245 0.0956
Brugia malayi hypothetical protein 0.0015 0.0245 0.09
Loa Loa (eye worm) hypothetical protein 0.0015 0.0245 0.09
Brugia malayi MH1 domain containing protein 0.0008 0.0094 0.0316
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0034 0.0639 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.2288 0.9992
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0957 0.365
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0722 0.3066
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0554 0.232
Trypanosoma brucei glucose transporter, putative 0.0034 0.0648 0.2738
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0245 0.0893
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0362 0.0656
Schistosoma mansoni hypothetical protein 0.0015 0.0242 0.1057
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0698 0.305
Entamoeba histolytica phosphofructokinase, putative 0.011 0.229 1
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0245 0.09
Schistosoma mansoni glucose transporter 0.0015 0.0245 0.1071
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0494 0.1861
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0742 0.3154
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0242 0.0879
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1224 0.1811
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0006 0.0045 0.0069
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0722 0.1368
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0698 0.2911
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Echinococcus granulosus solute carrier family 22 0.0015 0.0245 0.0893
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0722 0.3066
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0742 0.3154
Brugia malayi beta-lactamase family protein 0.0038 0.0722 0.2742
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0245 0.0956
Loa Loa (eye worm) hypothetical protein 0.0015 0.0245 0.09
Schistosoma mansoni sugar transporter 0.0015 0.0245 0.1071
Onchocerca volvulus 0.0038 0.0722 1
Entamoeba histolytica hypothetical protein 0.0036 0.0698 0.2911
Schistosoma mansoni glucose transport protein 0.011 0.2288 0.9992
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0245 0.0956
Schistosoma mansoni hypothetical protein 0.0015 0.0242 0.1057
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0245 0.0956
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0052 0.01
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0006 0.0045 0.0069
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0034 0.0639 0.242
Trypanosoma brucei glucose transporter 1E 0.0034 0.0648 0.2738
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0554 0.0511
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0034 0.0639 0.0925
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0012 0.0163 0.0592
Mycobacterium tuberculosis Conserved protein 0.0038 0.0722 0.1368
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0318 0.1276
Toxoplasma gondii ABC1 family protein 0.0038 0.0722 0.1051
Echinococcus multilocularis cpg binding protein 0.003 0.0567 0.2328
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0006 0.0045 0.0031
Schistosoma mansoni hypothetical protein 0.0015 0.0242 0.1057
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0052 0.01
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0025 0.0442 0.1824
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0722 0.3066
Schistosoma mansoni protein kinase 0.0034 0.0639 0.279
Plasmodium falciparum calcium-dependent protein kinase 3 0.0034 0.0639 0.0597
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1224 0.5285
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0318 0.1179
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0025 0.0442 0.1824
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0245 0.09
Echinococcus multilocularis calcium dependent protein kinase 0.0032 0.0594 0.2446
Schistosoma mansoni lamin 0.0027 0.0494 0.2157
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0052 0.01
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0318 0.1276
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0033 0.0624 0.2581
Leishmania major lysyl-tRNA synthetase, putative 0.0025 0.0442 0.1824
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0094 0.0221
Echinococcus granulosus solute carrier family 22 0.0015 0.0245 0.0893
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0006 0.0045 0.0069
Echinococcus granulosus lamin dm0 0.0027 0.0494 0.2001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0052 0.01
Loa Loa (eye worm) hypothetical protein 0.0027 0.049 0.1847
Loa Loa (eye worm) hypothetical protein 0.0038 0.0722 0.2742
Trypanosoma brucei glucose transporter, putative 0.0034 0.0648 0.2738
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0742 0.3154
Brugia malayi MH2 domain containing protein 0.0008 0.0094 0.0316
Loa Loa (eye worm) hypothetical protein 0.0033 0.0624 0.2363
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0722 0.1368
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0318 0.0274
Echinococcus granulosus General substrate transporter 0.0094 0.1954 0.8503
Leishmania major protein kinase, putative 0.0034 0.0639 0.2697
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.2288 0.9992
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0722 0.3154
Entamoeba histolytica phosphofructokinase, putative 0.011 0.229 1
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0245 0.0893
Echinococcus granulosus smad 0.0008 0.0094 0.0221
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0094 0.0221
Echinococcus granulosus calcium dependent protein kinase 0.0032 0.0594 0.2446
Echinococcus multilocularis solute carrier family 22 0.0015 0.0245 0.0893
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0648 0.2738
Echinococcus multilocularis lysyl tRNA synthetase 0.0025 0.0442 0.1768
Trichomonas vaginalis conserved hypothetical protein 0.011 0.2288 0.9992
Loa Loa (eye worm) hypothetical protein 0.0038 0.0722 0.2742
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0045 0.0069
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0318 0.1276
Entamoeba histolytica phosphofructokinase, putative 0.011 0.229 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0052 0.01
Loa Loa (eye worm) hypothetical protein 0.0015 0.0245 0.09
Loa Loa (eye worm) hypothetical protein 0.0038 0.0722 0.2742
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0245 0.0956
Plasmodium falciparum lysine--tRNA ligase 0.0025 0.0442 0.0399
Echinococcus granulosus solute carrier family 22 0.0015 0.0245 0.0893
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0742 0.3154
Giardia lamblia Prolyl-tRNA synthetase 0.0033 0.0624 1
Schistosoma mansoni hypothetical protein 0.0033 0.0626 0.2734
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.229 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0639 0.2646
Loa Loa (eye worm) hypothetical protein 0.0038 0.0722 0.2742
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0639 0.2646
Schistosoma mansoni smad1 5 8 and 0.0008 0.0094 0.0411
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0648 0.2738
Loa Loa (eye worm) phosphofructokinase 0.011 0.229 0.8798
Loa Loa (eye worm) hypothetical protein 0.0015 0.0245 0.09
Schistosoma mansoni protein kinase 0.0034 0.0639 0.279
Toxoplasma gondii glycyl-tRNA synthetase 0.0006 0.0045 0.0024
Toxoplasma gondii lysine-tRNA ligase 0.0025 0.0442 0.0625
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0902 0.3819
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.229 1
Toxoplasma gondii protein kinase, putative 0.0311 0.6627 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0648 0.2738
Onchocerca volvulus 0.0029 0.0532 0.6011
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0192 0.0658
Plasmodium vivax hexose transporter 0.011 0.2288 0.2253
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0006 0.0045 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0052 0.01
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0648 0.2738
Echinococcus granulosus lysyl tRNA synthetase 0.0025 0.0442 0.1768
Loa Loa (eye worm) hypothetical protein 0.0015 0.0245 0.09
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0065 0.0091
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0245 0.09
Mycobacterium leprae Probable lipase LipE 0.0038 0.0722 0.3066
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0722 0.3018
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0242 0.0879
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0052 0.01
Entamoeba histolytica hypothetical protein 0.0036 0.0698 0.2911
Brugia malayi Sugar transporter family protein 0.011 0.2288 0.8791
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0554 0.0795
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0192 0.0658
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.0742 0.1081
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0648 0.2738
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0722 0.3066
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.229 0.8798
Plasmodium vivax lysine--tRNA ligase, putative 0.0025 0.0442 0.0399
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0034 0.0639 0.0597
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0742 0.3154
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0245 0.0956
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0103 0.026
Giardia lamblia Sugar-proton symporter 0.0015 0.0245 0.346
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0245 0.0427
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.229 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0318 0.0274
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.0376 0.1535
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1224 0.5252
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0006 0.0045 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0245 0.0956
Onchocerca volvulus 0.0038 0.0722 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0245 0.0956
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0639 0.279
Toxoplasma gondii sugar transporter ST1 0.0015 0.0245 0.0327
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0314 0.126
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0245 0.1071
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0722 0.3018
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0722 0.1368
Loa Loa (eye worm) Smad1 0.0008 0.0094 0.0316
Echinococcus granulosus solute carrier family 22 0.0015 0.0245 0.0893
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1224 0.5345
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0554 0.232
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0052 0.01
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0033 0.0624 0.2363
Schistosoma mansoni 6-phosphofructokinase 0.011 0.229 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0033 0.0624 0.2363
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0245 0.0956
Echinococcus granulosus Smad4 0.0008 0.0094 0.0221
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0722 0.1368
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0052 0.01
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.2288 0.9992
Brugia malayi Sugar transporter family protein 0.0015 0.0245 0.09
Loa Loa (eye worm) hypothetical protein 0.0026 0.0483 0.182
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0033 0.0624 0.2581
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0554 0.232
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0178 0.3752 0.5643
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0101 0.0341
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0245 0.0427
Loa Loa (eye worm) hypothetical protein 0.0015 0.0245 0.09
Loa Loa (eye worm) hypothetical protein 0.0015 0.0245 0.09
Schistosoma mansoni sugar transporter 0.0015 0.0245 0.1071
Trypanosoma brucei glucose transporter, putative 0.0034 0.0648 0.2738
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0648 0.2738
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0318 0.1216
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0318 0.1276
Trypanosoma brucei glucose transporter, putative 0.0034 0.0648 0.2738
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0245 0.0893
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1224 0.2359
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0554 1
Mycobacterium ulcerans hypothetical protein 0.0038 0.0722 0.3066
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0722 0.0681
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.2288 0.9992
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0648 0.2738
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0722 0.3066
Trypanosoma brucei sugar transporter, putative 0.0015 0.0245 0.0956
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0318 0.1276
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0318 0.1216
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0554 0.232
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Brugia malayi lysyl-tRNA synthetase 0.0025 0.0442 0.1658
Trichomonas vaginalis CAMK family protein kinase 0.0034 0.0639 0.2697
Brugia malayi CXXC zinc finger family protein 0.0029 0.0532 0.2007
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0006 0.0045 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0052 0.01
Loa Loa (eye worm) hypothetical protein 0.0015 0.0245 0.09
Loa Loa (eye worm) hypothetical protein 0.0015 0.0245 0.09
Plasmodium falciparum mitogen-activated protein kinase 2 0.0178 0.3752 0.3724
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.229 1
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0722 0.3066
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Mycobacterium ulcerans lipase LipD 0.0038 0.0722 0.3066
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0223 0.0815
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0318 0.057
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1224 0.5285
Brugia malayi 6-phosphofructokinase 0.011 0.229 0.8798
Loa Loa (eye worm) hypothetical protein 0.0038 0.0722 0.2742
Chlamydia trachomatis proline--tRNA ligase 0.0012 0.0163 0.2322
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0554 0.0795
Echinococcus multilocularis solute carrier family 22 0.0015 0.0245 0.0893
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0698 0.2911
Plasmodium falciparum hexose transporter 0.011 0.2288 0.2253
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0245 0.0956
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0722 0.3066
Loa Loa (eye worm) hypothetical protein 0.0048 0.0957 0.365
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Schistosoma mansoni hypothetical protein 0.011 0.2288 0.9992
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0094 0.0411
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0722 0.1368
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1228 0.5363
Entamoeba histolytica hypothetical protein 0.0036 0.0698 0.2911
Loa Loa (eye worm) hypothetical protein 0.0015 0.0245 0.09
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0052 0.01
Onchocerca volvulus 0.0027 0.0494 0.5217
Schistosoma mansoni glucose transport protein 0.011 0.2288 0.9992
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0034 0.0639 0.0925
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0494 0.1861
Loa Loa (eye worm) hypothetical protein 0.0015 0.0245 0.09
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1224 0.5252
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0094 0.0221
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.011 0.2288 0.9992
Plasmodium falciparum protein kinase 7 0.0311 0.6627 0.6612
Brugia malayi MH2 domain containing protein 0.0124 0.2601 1
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.229 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0245 0.0893
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0648 0.2738
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Loa Loa (eye worm) hypothetical protein 0.0013 0.0182 0.0654
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0902 0.3819
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0639 0.2646
Schistosoma mansoni cpg binding protein 0.003 0.0567 0.2477
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0033 0.0624 0.2632
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0006 0.0045 0.0125
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0902 0.3819
Schistosoma mansoni glycyl-tRNA synthetase 0.0006 0.0045 0.0195
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0065 0.0091
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0722 0.3066
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0554 0.0511
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0957 0.365
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0648 0.2738
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Loa Loa (eye worm) hypothetical protein 0.0006 0.0045 0.0125
Brugia malayi MH1 domain containing protein 0.0008 0.0094 0.0316
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0034 0.0639 0.242
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0245 0.0956
Brugia malayi hypothetical protein 0.0015 0.0245 0.09
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0052 0.01
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0362 0.147
Mycobacterium tuberculosis Conserved protein 0.0038 0.0722 0.1368
Loa Loa (eye worm) hypothetical protein 0.0013 0.0192 0.0695
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0639 0.2646
Leishmania major threonyl-tRNA synthetase, putative 0.0006 0.0045 0.0069
Giardia lamblia Hexose transporter 0.0015 0.0245 0.346
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0554 0.2267
Brugia malayi intermediate filament protein 0.0027 0.0494 0.1861
Brugia malayi major facilitator superfamily protein 0.0015 0.0245 0.09
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0318 0.471
Schistosoma mansoni ap endonuclease 0.0019 0.0318 0.1387
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0034 0.0639 0.2646
Loa Loa (eye worm) hypothetical protein 0.0027 0.0494 0.1861
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0245 0.0956
Trypanosoma brucei glucose transporter, putative 0.0034 0.0648 0.2738
Echinococcus multilocularis lamin dm0 0.0027 0.0494 0.2001
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1224 0.5285
Echinococcus multilocularis lamin 0.0027 0.0494 0.2001
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0722 0.1368
Plasmodium falciparum calcium-dependent protein kinase 5 0.0034 0.0639 0.0597
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0006 0.0045 0.0125
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0624 0.2725
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0052 0.01
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0034 0.0639 0.0925
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0052 0.01
Plasmodium vivax sugar transporter, putative 0.0015 0.0245 0.0201
Schistosoma mansoni ap endonuclease 0.0019 0.0318 0.1387
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.011 0.2288 0.9992
Brugia malayi beta-lactamase family protein 0.0038 0.0722 0.2742
Schistosoma mansoni Smad4 0.0008 0.0094 0.0411
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0034 0.0639 0.2646
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0554 0.232
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.229 0.4464
Plasmodium falciparum calcium-dependent protein kinase 4 0.0034 0.0639 0.0597
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0245 0.7347
Schistosoma mansoni cpg binding protein 0.0029 0.0532 0.2323
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0902 0.3819
Trichomonas vaginalis esterase, putative 0.0038 0.0722 0.3066
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0722 0.3066
Loa Loa (eye worm) sugar transporter 0.0015 0.0245 0.09
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0006 0.0045 0.0024
Loa Loa (eye worm) beta-lactamase 0.0038 0.0722 0.2742
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0318 0.1216
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0094 0.0221
Schistosoma mansoni 6-phosphofructokinase 0.011 0.229 1
Trichomonas vaginalis helicase, putative 0.0007 0.0052 0.01
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0442 0.1928
Treponema pallidum prolyl-tRNA synthetase 0.0012 0.0163 0.0526
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1224 0.5345
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0554 0.232
Entamoeba histolytica protein kinase, putative 0.0034 0.0639 0.2646
Echinococcus granulosus intermediate filament protein 0.0027 0.0494 0.2001
Echinococcus multilocularis General substrate transporter 0.0094 0.1954 0.8503
Plasmodium falciparum calcium-dependent protein kinase 2 0.0034 0.0639 0.0597
Chlamydia trachomatis lysine--tRNA ligase 0.0025 0.0442 0.7797
Brugia malayi MH2 domain containing protein 0.0008 0.0094 0.0316
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0045 0.0069
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0554 0.0511
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.0742 0.0701
Trypanosoma brucei glucose transporter 2A 0.0034 0.0648 0.2738
Trypanosoma brucei glucose transporter, putative 0.0034 0.0648 0.2738
Echinococcus multilocularis solute carrier family 22 0.0015 0.0245 0.0893
Schistosoma mansoni intermediate filament proteins 0.0027 0.0494 0.2157
Schistosoma mansoni smad1 5 8 and 0.0008 0.0094 0.0411
Schistosoma mansoni glucose transport protein 0.011 0.2288 0.9992
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0245 0.0956
Brugia malayi phosphofructokinase 0.011 0.229 0.8798

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 19 % Antagonist activity at P2X7 receptor in human LPS-stimulated monocytes assessed as inhibition of ATP-induced IL1-beta release at 5 uM by ELISA ChEMBL. 21565499

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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