Detailed information for compound 155934

Basic information

Technical information
  • TDR Targets ID: 155934
  • Name: 5-(1,8-dihydroxy-9-oxo-10H-anthracen-2-yl)-N- hydroxy-N-methylpentanamide
  • MW: 355.384 | Formula: C20H21NO5
  • H donors: 3 H acceptors: 5 LogP: 3.3 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=O)CCCCc1ccc2c(c1O)C(=O)c1c(C2)cccc1O)O
  • InChi: 1S/C20H21NO5/c1-21(26)16(23)8-3-2-5-12-9-10-14-11-13-6-4-7-15(22)17(13)20(25)18(14)19(12)24/h4,6-7,9-10,22,24,26H,2-3,5,8,11H2,1H3
  • InChiKey: ZWOYICPUYHRHKG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-(1,8-dihydroxy-9-oxo-10H-anthracen-2-yl)-N-hydroxy-N-methyl-pentanamide
  • 5-(1,8-dihydroxy-9-keto-10H-anthracen-2-yl)-N-hydroxy-N-methyl-valeramide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Arachidonate 5-lipoxygenase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi mbt repeat family protein 0.0442 0.4459 0.5592
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.2184 0.2599
Echinococcus multilocularis liprin alpha 2 0.0024 0.0032 0.0037
Echinococcus multilocularis histone acetyltransferase MYST2 0.0093 0.0755 0.0876
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0032 0.004
Echinococcus granulosus polyhomeotic protein 2 0.0024 0.0032 0.0037
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0026 0.0041
Schistosoma mansoni hypothetical protein 0.0612 0.6269 0.7268
Schistosoma mansoni cpg binding protein 0.0059 0.0395 0.0457
Echinococcus multilocularis RUN 0.0024 0.0026 0.003
Schistosoma mansoni hypothetical protein 0.0179 0.1667 0.1933
Loa Loa (eye worm) hypothetical protein 0.0057 0.0382 0.0609
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.1087 0.1197
Brugia malayi beta-lactamase family protein 0.0036 0.015 0.0189
Schistosoma mansoni chromobox protein 0.019 0.1793 0.2079
Loa Loa (eye worm) tnks protein 0.0024 0.0032 0.005
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.129 0.2059
Schistosoma mansoni hypothetical protein 0.0773 0.7974 0.9245
Onchocerca volvulus 0.0024 0.0032 0.0006
Trichomonas vaginalis cgi-62, putative 0.0024 0.0032 0.004
Trypanosoma cruzi Kinesin-13 5, putative 0.0024 0.0032 0.1183
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0026 0.003
Toxoplasma gondii PLU-1 family protein 0.0042 0.0223 0.2055
Brugia malayi coiled-coil like protein 1 0.0024 0.0032 0.004
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0504 0.5117 0.5933
Mycobacterium tuberculosis Long conserved protein 0.0773 0.7974 1
Mycobacterium tuberculosis Hypothetical protein 0.0773 0.7974 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0431 0.0499
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0024 0.0032 0.0037
Loa Loa (eye worm) CHromoDomain protein family member 0.0029 0.0085 0.0136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.129 0.1496
Schistosoma mansoni hypothetical protein 0.0179 0.1667 0.1933
Brugia malayi beta-lactamase 0.0036 0.015 0.0189
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0114 0.0978 0.1134
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0024 0.0032 0.005
Brugia malayi Sphingomyelin synthase-related 1 0.0024 0.0032 0.004
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0612 0.6269 1
Schistosoma mansoni cpg binding protein 0.0077 0.0589 0.0683
Echinococcus granulosus Sterile alpha motif type 0.0024 0.0032 0.0037
Entamoeba histolytica hypothetical protein 0.0022 0.0005 0.0206
Schistosoma mansoni polycystin 1-related 0.0024 0.0026 0.003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0032 0.004
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0801 0.8272 0.9591
Onchocerca volvulus 0.0024 0.0032 0.0006
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.015 0.0189
Loa Loa (eye worm) hypothetical protein 0.0442 0.4459 0.7114
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.015 0.0174
Echinococcus granulosus lysine specific demethylase 5A 0.0093 0.0762 0.0884
Mycobacterium ulcerans hypothetical protein 0.0773 0.7974 1
Brugia malayi cask-interacting protein 2 0.0024 0.0032 0.004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.129 0.1496
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0442 0.4459 0.4445
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.1087 0.1197
Giardia lamblia Hypothetical protein 0.0773 0.7974 1
Brugia malayi hypothetical protein 0.0024 0.0026 0.0032
Onchocerca volvulus 0.0292 0.2866 0.2848
Loa Loa (eye worm) MBCTL1 0.0093 0.0755 0.1205
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.0266 1
Onchocerca volvulus Tankyrase homolog 0.0024 0.0032 0.0006
Mycobacterium ulcerans hypothetical protein 0.0773 0.7974 1
Brugia malayi RNA binding protein 0.0062 0.0431 0.054
Plasmodium vivax hypothetical protein, conserved 0.0036 0.015 0.3942
Brugia malayi TAR-binding protein 0.0062 0.0431 0.054
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0032 0.004
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.005
Mycobacterium tuberculosis Conserved hypothetical protein 0.0773 0.7974 1
Schistosoma mansoni lipoxygenase 0.0142 0.1284 0.1489
Loa Loa (eye worm) hypothetical protein 0.0036 0.015 0.024
Echinococcus granulosus dnaJ subfamily B 0.0834 0.8625 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0093 0.0762 0.0884
Schistosoma mansoni jumonji/arid domain-containing protein 0.0093 0.0762 0.0884
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0124 0.1087 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0124 0.1087 0.126
Echinococcus granulosus sphingomyelin synthase protein 1 0.0024 0.0032 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0431 0.0499
Brugia malayi F/Y-rich N-terminus family protein 0.0033 0.0122 0.0153
Loa Loa (eye worm) hypothetical protein 0.0036 0.015 0.024
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0431 0.054
Onchocerca volvulus 0.0024 0.0032 0.0006
Giardia lamblia Transglutaminase/protease, putative 0.0773 0.7974 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0026 0.003
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0504 0.5117 0.5933
Schistosoma mansoni loxhd1 0.0024 0.0026 0.003
Brugia malayi Thioredoxin family protein 0.0773 0.7974 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.1087 0.1197
Echinococcus granulosus cpg binding protein 0.0077 0.0589 0.0683
Brugia malayi bicaudal-C 0.0024 0.0032 0.004
Loa Loa (eye worm) hypothetical protein 0.0036 0.015 0.024
Schistosoma mansoni rab6-interacting 0.0024 0.0026 0.003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.005
Mycobacterium tuberculosis Conserved hypothetical protein 0.0773 0.7974 1
Schistosoma mansoni phd finger protein 0.0043 0.0226 0.0262
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0026 0.0671
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.129 0.1496
Schistosoma mansoni DNAj-like protein 0.0024 0.0032 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0431 0.0499
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.005
Plasmodium vivax protein kinase, putative 0.0024 0.0032 0.0826
Echinococcus granulosus histone acetyltransferase MYST2 0.0093 0.0755 0.0876
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0026 0.003
Mycobacterium leprae Conserved hypothetical protein 0.0773 0.7974 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0395 0.0629
Onchocerca volvulus 0.0024 0.0032 0.0006
Schistosoma mansoni hypothetical protein 0.0024 0.0032 0.0037
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0029 0.0085 0.0099
Loa Loa (eye worm) beta-lactamase 0.0036 0.015 0.024
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0431 0.0687
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0431 0.0499
Loa Loa (eye worm) hypothetical protein 0.0093 0.0755 0.1205
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0382 0.351
Schistosoma mansoni spingomyelin synthetase-related 0.0024 0.0032 0.0037
Echinococcus multilocularis Transglutaminase 0.0773 0.7974 0.9245
Schistosoma mansoni myst-related protein 0.0022 0.0005 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.129 0.1496
Trichomonas vaginalis peptide N-glycanase, putative 0.0773 0.7974 1
Echinococcus granulosus Transglutaminase 0.0773 0.7974 0.9245
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0093 0.0755 0.0876
Loa Loa (eye worm) hypothetical protein 0.0036 0.015 0.024
Plasmodium falciparum zinc finger protein, putative 0.0022 0.0005 0.0144
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0124 0.1087 0.126
Brugia malayi hypothetical protein 0.0024 0.0032 0.004
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0025 0.0034 0.0039
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0382 1
Echinococcus granulosus liprin alpha 2 0.0024 0.0032 0.0037
Mycobacterium ulcerans putative transglutaminase-like protein 0.0773 0.7974 1
Loa Loa (eye worm) mbt repeat family protein 0.0267 0.2608 0.416
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.1284 0.1489
Brugia malayi Importin beta-1 subunit 0.0057 0.0382 0.0478
Schistosoma mansoni importin beta-1 0.0057 0.0382 0.0442
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0024 0.0032 0.004
Trypanosoma cruzi Kinesin-13 5, putative 0.0024 0.0032 0.1183
Brugia malayi Doublecortin family protein 0.0024 0.0026 0.0032
Echinococcus multilocularis polyhomeotic proximal chromatin protein 0.0024 0.0032 0.0037
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.0951 0.8744
Echinococcus granulosus snurportin 1 0.0612 0.6269 0.7268
Trypanosoma brucei SAM domain (Sterile alpha motif), putative 0.0024 0.0032 0.0826
Brugia malayi jmjC domain containing protein 0.0136 0.1213 0.1521
Plasmodium vivax JmjC domain containing protein 0.0028 0.0071 0.1864
Brugia malayi AIDA-1b 0.0024 0.0032 0.004
Toxoplasma gondii ABC1 family protein 0.0036 0.015 0.1383
Onchocerca volvulus 0.0036 0.015 0.0125
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.129 0.1496
Toxoplasma gondii hypothetical protein 0.0025 0.0035 0.0325
Echinococcus multilocularis Sterile alpha motif SAM 0.0024 0.0032 0.0037
Echinococcus multilocularis tumor suppressor p53 binding protein 1 0.0316 0.3128 0.3626
Trypanosoma cruzi hypothetical protein 0.0024 0.0032 0.1183
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.1087 0.126
Echinococcus granulosus RUN 0.0024 0.0026 0.003
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0114 0.0978 0.1134
Echinococcus granulosus pdz domain containing protein 0.0024 0.0032 0.0037
Toxoplasma gondii aldehyde dehydrogenase 0.0124 0.1087 1
Schistosoma mansoni hypothetical protein 0.0834 0.8625 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0372 0.3718 0.4311
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0032 0.004
Brugia malayi jmjC domain containing protein 0.0025 0.0034 0.0042
Schistosoma mansoni hypothetical protein 0.0024 0.0032 0.0037
Echinococcus granulosus chromobox protein 2 0.019 0.1793 0.2079
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0026 0.003
Echinococcus multilocularis lysine specific demethylase 5A 0.0075 0.0568 0.0658
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.015 0.0189
Schistosoma mansoni rab6-interacting 0.0024 0.0026 0.003
Brugia malayi beta-lactamase family protein 0.0036 0.015 0.0189
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0032 0.004
Brugia malayi hypothetical protein 0.0024 0.0026 0.0032
Loa Loa (eye worm) AIDA-1b 0.0024 0.0032 0.005
Giardia lamblia Giardia trophozoite antigen GTA-1 0.0024 0.0032 0.004
Giardia lamblia Kinesin-13 0.0024 0.0032 0.004
Mycobacterium leprae Conserved hypothetical protein 0.0773 0.7974 1
Onchocerca volvulus 0.0059 0.0395 0.037
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0382 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.015 0.0174
Leishmania major hypothetical protein, conserved 0.0036 0.015 0.1383
Echinococcus granulosus importin subunit beta 1 0.0057 0.0382 0.0442
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0266 0.0334
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0031 0.0105 0.0964
Loa Loa (eye worm) hypothetical protein 0.0036 0.015 0.024
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0029 0.0085 0.0099
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0024 0.0032 0.0037
Onchocerca volvulus 0.0024 0.0032 0.0006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.015 0.0174
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.005
Schistosoma mansoni sex comb on midleg homolog 0.0257 0.2497 0.2895
Loa Loa (eye worm) RNA binding protein 0.0062 0.0431 0.0687
Loa Loa (eye worm) hypothetical protein 0.0024 0.0026 0.0041
Loa Loa (eye worm) hypothetical protein 0.0024 0.0026 0.0041
Schistosoma mansoni hypothetical protein 0.0316 0.3128 0.3626
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.015 0.0189
Loa Loa (eye worm) jmjC domain-containing protein 0.0136 0.1213 0.1935
Schistosoma mansoni lip-related protein (liprin) alpha 0.0024 0.0032 0.0037
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.005
Schistosoma mansoni hypothetical protein 0.0829 0.8564 0.993
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.015 0.0174
Echinococcus multilocularis dnaJ subfamily B 0.0834 0.8625 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0431 0.0687
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 24 0.0024 0.0032 0.0826
Echinococcus granulosus geminin 0.0179 0.1667 0.1933
Schistosoma mansoni hypothetical protein 0.0024 0.0026 0.003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.1091 0.1265
Schistosoma mansoni sex comb on midleg homolog 0.0257 0.2497 0.2895
Echinococcus granulosus tumor suppressor p53 binding protein 1 0.0316 0.3128 0.3626
Echinococcus granulosus histone acetyltransferase myst3 0.0043 0.0226 0.0262
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0034 0.0039
Onchocerca volvulus 0.0036 0.015 0.0125
Onchocerca volvulus 0.0036 0.015 0.0125
Onchocerca volvulus 0.0024 0.0032 0.0006
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0025 0.0034 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0431 0.0499
Schistosoma mansoni lipoxygenase 0.01 0.0829 0.0961
Brugia malayi CHD4 protein 0.0029 0.0085 0.0107
Echinococcus multilocularis pdz domain containing protein 0.0024 0.0032 0.0037
Schistosoma mansoni cpg binding protein 0.0077 0.0589 0.0683
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.015 0.0189
Plasmodium falciparum importin beta, putative 0.0057 0.0382 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0093 0.0755 0.0947
Schistosoma mansoni myelin transcription factor 1 myt1 0.0093 0.0755 0.0876
Leishmania major importin beta-1 subunit, putative 0.0047 0.0266 0.2451
Schistosoma mansoni myst-related protein 0.0022 0.0005 0.0006
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0024 0.0032 0.0037
Echinococcus multilocularis chromobox protein 2 0.019 0.1793 0.2079
Brugia malayi RNA, U transporter 1 0.0163 0.1503 0.1885
Brugia malayi Shank2E 0.0024 0.0032 0.004
Schistosoma mansoni polyhomeotic 0.0024 0.0032 0.0037
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.1087 0.126
Echinococcus multilocularis polycomb protein SCMH1 0.0257 0.2497 0.2895
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0032 0.004
Echinococcus granulosus SAM and MBT domain containing protein 0.0372 0.3718 0.4311
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0032 0.004
Mycobacterium ulcerans transglutaminase family protein 0.0773 0.7974 1
Echinococcus multilocularis Sterile alpha motif type 0.0024 0.0032 0.0037
Loa Loa (eye worm) hypothetical protein 0.0036 0.015 0.024
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0431 0.0499
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.005
Echinococcus multilocularis geminin 0.0179 0.1667 0.1933
Plasmodium vivax importin-beta 2, putative 0.0057 0.0382 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0372 0.3718 0.4311
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.015 0.5645
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0093 0.0755 0.0876
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.129 0.1496
Brugia malayi hypothetical protein 0.0024 0.0032 0.004
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0026 0.003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0032 0.004
Echinococcus multilocularis cpg binding protein 0.0077 0.0589 0.0683
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.015 0.5645
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.015 0.024
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.0024 0.0032 0.004
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0026 0.003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.005
Echinococcus granulosus liprin alpha 2 0.0024 0.0032 0.0037
Echinococcus multilocularis histone acetyltransferase myst3 0.0043 0.0226 0.0262
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.015 0.0189
Echinococcus multilocularis liprin alpha 2 0.0024 0.0032 0.0037
Schistosoma mansoni Protein aveugle 0.0024 0.0032 0.0037
Echinococcus granulosus tar DNA binding protein 0.0062 0.0431 0.0499
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.005
Brugia malayi mbt repeat family protein 0.0267 0.2608 0.327
Echinococcus multilocularis polyhomeotic protein 2 0.0024 0.0032 0.0037
Echinococcus granulosus polyhomeotic proximal chromatin protein 0.0024 0.0032 0.0037
Brugia malayi Liprin-alpha 2 0.0024 0.0032 0.004
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0124 0.1087 0.1197
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.015 0.3942
Plasmodium falciparum JmjC domain-containing protein, putative 0.0028 0.0071 0.1864
Echinococcus granulosus Sterile alpha motif SAM 0.0024 0.0032 0.0037
Echinococcus granulosus polycomb protein SCMH1 0.0257 0.2497 0.2895
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.015 0.0189
Entamoeba histolytica hypothetical protein 0.0047 0.0266 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0029 0.0085 0.0099
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0266 0.0334
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0026 0.0671
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.129 0.1618
Brugia malayi CXXC zinc finger family protein 0.0059 0.0395 0.0495
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0032 0.004
Trichomonas vaginalis esterase, putative 0.0036 0.015 0.0189
Schistosoma mansoni Protein aveugle 0.0024 0.0032 0.0037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.129 0.1496
Echinococcus multilocularis snurportin 1 0.0612 0.6269 0.7268
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0024 0.0032 0.0037
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0382 0.0442
Mycobacterium tuberculosis Conserved protein 0.0773 0.7974 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.1284 0.1489
Trichomonas vaginalis importin beta-1, putative 0.0047 0.0266 0.0334

Activities

Activity type Activity value Assay description Source Reference
DD (binding) = 1.36 uM Antioxidant activity, measuring Deoxyribose degradation (DD) as a measure of hydroxyl radical formation. ChEMBL. 9276024
IC50 (functional) = 0.5 uM 5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leukocytes ChEMBL. 9276024
IC50 (functional) = 0.5 uM 5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leukocytes ChEMBL. 9276024
IC50 (functional) = 0.8 uM Antiproliferative activity (AA) against HaCaT keratinocytes. ChEMBL. 9276024
IC50 (functional) = 0.8 uM Antiproliferative activity (AA) against HaCaT keratinocytes. ChEMBL. 9276024
LDH (functional) = 124 MU Cytotoxicity of LDH release in HaCaT cells ChEMBL. 9276024
LDH (functional) = 124 MU Cytotoxicity of LDH release in HaCaT cells ChEMBL. 9276024

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 9276024

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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