Detailed information for compound 1563419

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 641.498 | Formula: C26H36IN5O6
  • H donors: 5 H acceptors: 7 LogP: 2.91 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H]1O[C@@H](CCCCCCCCn2cnc3c2nc(N)nc3OCc2cccc(c2)I)[C@@H]([C@H]([C@@H]1O)O)O
  • InChi: 1S/C26H36IN5O6/c27-17-9-7-8-16(12-17)14-37-25-20-24(30-26(28)31-25)32(15-29-20)11-6-4-2-1-3-5-10-18-21(34)23(36)22(35)19(13-33)38-18/h7-9,12,15,18-19,21-23,33-36H,1-6,10-11,13-14H2,(H2,28,30,31)/t18-,19+,21-,22+,23+/m0/s1
  • InChiKey: KDUHUDLWBRQSMF-RNJSZURPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cytochrome p450-like protein 0.0012 0.0004 0.0091
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0014 0.0014
Loa Loa (eye worm) FAD binding domain-containing protein 0.0023 0.0018 0.0018
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0011 0.0003 0.0003
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.002 0.0014 0.0014
Brugia malayi FAD binding domain containing protein 0.0023 0.0018 0.0017
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0062 1
Echinococcus granulosus 3'partial|arginase 2 mitochondrial 0.0365 0.0442 0.0441
Loa Loa (eye worm) serotonin transporter b 0.8076 1 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.0964 0.0963
Echinococcus multilocularis cytosolic carboxypeptidase protein 5 0.001 0.0002 0.0001
Schistosoma mansoni carboxypeptidase N (M14 family) 0.001 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0023 0.0018 0.1127
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Leishmania major agmatinase-like protein 0.0133 0.0154 0.3484
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.1371 0.1689 0.1688
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.1371 0.1689 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0001 0.0001
Giardia lamblia Nitric oxide synthase, inducible 0.002 0.0014 0.6663
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Brugia malayi Flap endonuclease-1 0.0025 0.0021 0.0021
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0009 0.0001 0.0001
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.1371 0.1689 0.1688
Brugia malayi hypothetical protein 0.0009 0.0001 0.0001
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0023 0.0018 0.0392
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0023 0.0018 0.0103
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0011 0.0003 0.0002
Echinococcus multilocularis arginase 2, mitochondrial 0.0365 0.0442 0.0441
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Schistosoma mansoni metallocarboxypeptidase D peptidase unit 2 (M14 family) 0.001 0.0002 0.0001
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.001 0.0002 0.0031
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.1371 0.1689 0.1688
Onchocerca volvulus Subfamily M14A unassigned peptidase homolog 0.0057 0.006 0.0059
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.002 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Schistosoma mansoni nAChR subunit 0.002 0.0014 0.0013
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0014 0.0013
Brugia malayi hypothetical protein 0.1371 0.1689 0.1689
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0014 0.0013
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1371 0.1689 0.1689
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0023 0.0018 0.1127
Toxoplasma gondii hypothetical protein 0.1371 0.1689 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0024 0.0023
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0023 0.0018 0.1127
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0023 0.0018 0.2286
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0002 0.0001
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14 0.001 0.0002 0.0088
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0014 0.0013
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0062 1
Schistosoma mansoni family M14 non-peptidase homologue (M14 family) 0.001 0.0002 0.0001
Brugia malayi hypothetical protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.002 0.0014 0.0014
Leishmania major arginase 0.0365 0.0442 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Brugia malayi hypothetical protein 0.0009 0.0001 0.0001
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0021 1
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.0057 0.006 0.0059
Echinococcus multilocularis 0.001 0.0002 0.0001
Schistosoma mansoni sodium/chloride dependent transporter 0.1371 0.1689 0.1688
Echinococcus multilocularis nAChR subunit 0.0011 0.0003 0.0002
Onchocerca volvulus Cytosolic carboxypeptidase 1 homolog 0.001 0.0002 0.0001
Onchocerca volvulus 0.001 0.0002 0.0001
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0062 0.5
Toxoplasma gondii flavodoxin domain-containing protein 0.0011 0.0003 0.0011
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0014 0.0013
Entamoeba histolytica hypothetical protein 0.0011 0.0003 0.006
Schistosoma mansoni nAChR subunit 0.002 0.0014 0.0013
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.001 0.0002 0.0088
Trypanosoma brucei agmatinase, putative 0.0133 0.0154 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.024 0.024
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0023 0.0018 0.0017
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0062 0.1409
Schistosoma mansoni sodium-dependent amino acid transporter 0.1371 0.1689 0.1688
Loa Loa (eye worm) LGC-31 protein 0.002 0.0014 0.0014
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.1371 0.1689 0.1688
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.002 0.0014 0.0013
Echinococcus multilocularis methionine synthase reductase 0.0014 0.0007 0.0006
Plasmodium vivax arginase, putative 0.0365 0.0442 0.2616
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0023 0.0018 0.1127
Echinococcus multilocularis Zinc carboxypeptidase family protein 0.001 0.0002 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0365 0.0442 1
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.1371 0.1689 0.1689
Trypanosoma cruzi p450 reductase, putative 0.0023 0.0018 0.1127
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0002 0.0001
Echinococcus granulosus Zinc carboxypeptidase family protein 0.001 0.0002 0.0001
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0014 0.0013
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0025 0.0024
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0014 0.0013
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0021 0.1335
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.001 0.0002 0.0031
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0014 0.0013
Plasmodium vivax flavodoxin domain containing protein 0.002 0.0014 0.0084
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.1371 0.1689 0.1688
Schistosoma mansoni nAChR subunit 0.002 0.0014 0.0013
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.1371 0.1689 1
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.001 0.0002 0.0031
Onchocerca volvulus 0.0057 0.006 0.0059
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0018
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0014 0.0014
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.002 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.1371 0.1689 0.1689
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1371 0.1689 0.1688
Echinococcus granulosus uncharacterized sodium dependent transporter 0.1371 0.1689 0.1688
Trichomonas vaginalis sulfite reductase, putative 0.0023 0.0018 0.0392
Onchocerca volvulus 0.0057 0.006 0.0059
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Schistosoma mansoni flap endonuclease-1 0.0023 0.0018 0.0017
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.002 0.0014 0.0014
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.001 0.0002 0.0031
Schistosoma mansoni cytochrome P450 reductase 0.0023 0.0018 0.0017
Trypanosoma brucei Carboxypeptidase-like protein 0.001 0.0002 0.0088
Onchocerca volvulus 0.0057 0.006 0.0059
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0023 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.1371 0.1689 0.1689
Trypanosoma cruzi arginase, putative 0.0133 0.0154 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0062 0.0062
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0062 0.0062
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.001 0.0002 0.0031
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.1371 0.1689 0.1688
Echinococcus granulosus methionine synthase reductase 0.0014 0.0007 0.0006
Plasmodium vivax hypothetical protein, conserved 0.001 0.0002 0.0008
Onchocerca volvulus 0.0011 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.1371 0.1689 0.1689
Echinococcus granulosus sodium and chloride dependent glycine 0.1371 0.1689 0.1688
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0021 0.0465
Echinococcus granulosus serotonin transporter 0.8076 1 1
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.002 0.0014 0.0013
Loa Loa (eye worm) ACC-1 protein 0.002 0.0014 0.0014
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0009 0.0001 0.0001
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0021 0.0465
Onchocerca volvulus 0.023 0.0274 0.0273
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Brugia malayi Pre-SET motif family protein 0.0202 0.024 0.0239
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0023 0.0018 0.1127
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.001 0.0002 0.0088
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.1371 0.1689 0.1688
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0002 0.0001
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.002 0.0014 0.0014
Onchocerca volvulus 0.002 0.0014 0.0013
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1371 0.1689 0.1689
Trypanosoma cruzi Carboxypeptidase-like protein 0.001 0.0002 0.0088
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.8076 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0014 0.0013
Loa Loa (eye worm) acetylcholine receptor protein 0.0009 0.0001 0.0001
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0062 0.0062
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0025 0.0024
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0002 0.0001
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.002 0.0014 0.0014
Plasmodium falciparum amino acid transporter, putative 0.1371 0.1689 1
Brugia malayi excitatory GABA receptor EXP-1A 0.002 0.0014 0.0014
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.1371 0.1689 0.1689
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.001 0.0002 0.0031
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Schistosoma mansoni nAChR subunit 0.002 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Schistosoma mansoni neurotransmitter gated ion channel 0.0011 0.0003 0.0002
Schistosoma mansoni nAChR subunit 0.002 0.0014 0.0013
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.001 0.0002 0.0031
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0014 0.0013
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.1371 0.1689 1
Schistosoma mansoni peptidase 0.001 0.0002 0.0001
Echinococcus granulosus cytosolic carboxypeptidase 1 0.001 0.0002 0.0001
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.001 0.0002 0.0031
Loa Loa (eye worm) hypothetical protein 0.0047 0.0048 0.0048
Brugia malayi Pre-SET motif family protein 0.0029 0.0025 0.0025
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0014 0.0014
Plasmodium vivax amine transporter, putative 0.1371 0.1689 1
Schistosoma mansoni nAChR subunit 0.002 0.0014 0.0013
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.002 0.0014 0.0013
Plasmodium vivax hypothetical protein, conserved 0.1371 0.1689 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0025
Brugia malayi Cation transporter family protein 0.002 0.0014 0.0014
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.002 0.0014 0.0014
Onchocerca volvulus 0.0057 0.006 0.0059
Brugia malayi Cytochrome P450 family protein 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0003
Trichomonas vaginalis Arginase, putative 0.0365 0.0442 1
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.002 0.0014 0.0014
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0023 0.0018 0.1127
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.1371 0.1689 0.1688
Loa Loa (eye worm) FAD binding domain-containing protein 0.0014 0.0007 0.0007
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0021 0.0114
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0009 0.0001 0.0001
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0004 0.0262
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Toxoplasma gondii flavodoxin domain-containing protein 0.0011 0.0003 0.0011
Treponema pallidum sodium- and chloride- dependent transporter 0.8076 1 1
Echinococcus granulosus cytosolic carboxypeptidase protein 5 0.001 0.0002 0.0001
Schistosoma mansoni NADPH flavin oxidoreductase 0.0011 0.0004 0.0003
Brugia malayi FAD binding domain containing protein 0.0014 0.0007 0.0007
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0011 0.0003 0.0003
Brugia malayi flavodoxin family protein 0.0023 0.0018 0.0017
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.001 0.0002 0.0031
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0025 0.0024
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0001 0.0001
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Loa Loa (eye worm) zinc carboxypeptidase 0.001 0.0002 0.0002
Schistosoma mansoni nAChR subunit 0.002 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Toxoplasma gondii hypothetical protein 0.1371 0.1689 1
Schistosoma mansoni peptidase 0.001 0.0002 0.0001
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.001 0.0002 0.0031
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.002 0.0014 0.0013
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.001 0.0002 0.0031
Plasmodium falciparum flap endonuclease 1 0.0025 0.0021 0.0122
Onchocerca volvulus 0.002 0.0014 0.0013
Onchocerca volvulus 0.002 0.0014 0.0013
Loa Loa (eye worm) ACC-1 protein 0.002 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0004 0.0262
Plasmodium vivax SET domain protein, putative 0.0029 0.0025 0.0149
Echinococcus multilocularis sodium and chloride dependent glycine 0.1371 0.1689 0.1688
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0003
Brugia malayi Cation transporter family protein 0.002 0.0014 0.0014
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.002 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.1371 0.1689 0.1689
Loa Loa (eye worm) hypothetical protein 0.8076 1 1
Schistosoma mansoni diflavin oxidoreductase 0.0011 0.0003 0.0002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0014 0.0014
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0002 0.0001
Brugia malayi hypothetical protein 0.0009 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0025 0.0024
Loa Loa (eye worm) zinc carboxypeptidase 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.1371 0.1689 0.1689
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.002 0.0014 0.0013
Echinococcus granulosus uncharacterized sodium dependent transporter 0.1371 0.1689 0.1688
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.0057 0.006 0.0059
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.001 0.0002 0.0031
Loa Loa (eye worm) norepinephrine transporter 0.8076 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0025 0.0024
Loa Loa (eye worm) zinc carboxypeptidase 0.001 0.0002 0.0002
Trypanosoma cruzi agmatinase, putative 0.0133 0.0154 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0011 0.0003 0.0003
Schistosoma mansoni sodium/chloride dependent transporter 0.1371 0.1689 0.1688
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Onchocerca volvulus 0.002 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Echinococcus multilocularis nAChR subunit 0.002 0.0014 0.0013
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.001 0.0002 0.0031
Echinococcus granulosus nAChR subunit 0.0011 0.0003 0.0002
Echinococcus granulosus flap endonuclease 1 0.0025 0.0021 0.002
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0002 0.0001
Onchocerca volvulus Carboxypeptidase D homolog 0.001 0.0002 0.0001
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1371 0.1689 0.1688
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1371 0.1689 0.1689
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0014 0.0014
Trypanosoma cruzi arginase, putative 0.0133 0.0154 1
Onchocerca volvulus 0.8076 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0003
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0002 0.0001
Onchocerca volvulus 0.001 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.8076 1 1
Schistosoma mansoni hypothetical protein 0.001 0.0002 0.0001
Brugia malayi Zinc carboxypeptidase family protein 0.001 0.0002 0.0001
Echinococcus multilocularis serotonin transporter 0.8076 1 1
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0023 0.0018 0.1127
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0014 0.0013
Schistosoma mansoni protease m14 carboxypeptidase 0.001 0.0002 0.0001
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.1371 0.1689 0.1688
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0023 0.0018 0.0017
Onchocerca volvulus 0.1371 0.1689 0.1688
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0003
Loa Loa (eye worm) GABA receptor subunit 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.001 0.0002 0.0088
Onchocerca volvulus 0.002 0.0014 0.0013
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0014 0.0013
Schistosoma mansoni peptidase 0.001 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Loa Loa (eye worm) solute carrier family 6 member 4 0.8076 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.8076 1 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.1371 0.1689 0.1688
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0014 0.0013
Entamoeba histolytica Arginase, putative 0.0365 0.0442 1
Plasmodium falciparum nitric oxide synthase, putative 0.0023 0.0018 0.0103
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0062 1
Brugia malayi hypothetical protein 0.0009 0.0001 0.0001
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0023 0.0018 0.0017
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.002 0.0014 0.0013
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0021 0.0122
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0062 0.0361
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0003
Brugia malayi Cytochrome P450 family protein 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0003
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0004 0.0004
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0009 0.0001 0.0001
Trypanosoma cruzi agmatinase, putative 0.0133 0.0154 1
Echinococcus granulosus sodium and chloride dependent glycine 0.1371 0.1689 0.1688
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Onchocerca volvulus 0.002 0.0014 0.0013
Schistosoma mansoni sodium/chloride dependent transporter 0.8076 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Brugia malayi Cation transporter family protein 0.002 0.0014 0.0014
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0014 0.0007 0.0006
Leishmania major p450 reductase, putative 0.0023 0.0018 0.0392
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0014 0.0013
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.002 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Onchocerca volvulus 0.1371 0.1689 0.1688
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.001 0.0002 0.0031
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Echinococcus multilocularis 0.0365 0.0442 0.0441
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.002 0.0014 0.0014
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.002 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0014 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0365 0.0442 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0062 0.0062
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0011 0.0003 0.0002
Echinococcus granulosus arginase 2 mitochondrial 0.0365 0.0442 0.0441
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0004 0.0004
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.1371 0.1689 0.1688
Brugia malayi Carboxypeptidase A2 precursor 0.001 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.1371 0.1689 0.1689
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0014 0.0014
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.1371 0.1689 1
Loa Loa (eye worm) hypothetical protein 0.1371 0.1689 0.1689
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0003
Leishmania major cytochrome P450 reductase, putative 0.002 0.0014 0.032
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Trypanosoma cruzi zinc carboxypeptidase, putative 0.001 0.0002 0.0088
Onchocerca volvulus 0.0011 0.0003 0.0002
Onchocerca volvulus Putative nachr subunit 0.002 0.0014 0.0013
Echinococcus granulosus nAChR subunit 0.002 0.0014 0.0013
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0021 0.0465
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0014 0.0014
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0014 0.0013
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.001 0.0002 0.0088
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0014 0.0014
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0025 0.0141
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0003
Plasmodium falciparum transporter, putative 0.1371 0.1689 1
Loa Loa (eye worm) hypothetical protein 0.1371 0.1689 0.1689
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.002 0.0014 0.0013
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0025 0.0024
Echinococcus granulosus subfamily M14A unassigned peptidase 0.0057 0.006 0.0059
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0021 0.1335
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0004 0.0262
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0009 0.0001 0.0001
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0009 0.0001 0.0001
Loa Loa (eye worm) zinc carboxypeptidase 0.001 0.0002 0.0002
Giardia lamblia Hypothetical protein 0.002 0.0014 0.6663
Onchocerca volvulus 0.1371 0.1689 0.1688
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.002 0.0014 0.0013
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.002 0.0014 0.0014
Schistosoma mansoni arginase 0.0365 0.0442 0.0441
Trichomonas vaginalis set domain proteins, putative 0.023 0.0274 0.62
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.002 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0001
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.002 0.0014 0.032
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.002 0.0014 0.0014
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0021 0.0021
Onchocerca volvulus 0.0029 0.0025 0.0024
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.1371 0.1689 0.1688
Plasmodium falciparum arginase 0.0365 0.0442 0.2616
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.002 0.0014 0.0014
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.002 0.0014 0.0013

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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