TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 477.614 | Formula: C25H35NO6S
H donors: 2 H acceptors: 2 LogP: 4.3 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1cccc(c1)[S@+](C)[O-])CC[C@H]1O[C@@H]2O[C@@]3(C)CC[C@@H]4[C@]2([C@H]([C@H]1C)CC[C@H]4C)OO3
InChi: 1S/C25H35NO6S/c1-15-8-9-20-16(2)21(10-11-22(27)26-17-6-5-7-18(14-17)33(4)28)29-23-25(20)19(15)12-13-24(3,30-23)31-32-25/h5-7,14-16,19-21,23H,8-13H2,1-4H3,(H,26,27)/t15-,16-,19+,20+,21-,23-,24-,25-,33+/m1/s1
InChiKey: PKBIJBJKFNUHDW-XRWGMKSCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	BEN-1 protein	0.126374	1	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0724399	0.554106	0.542889
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0730298	0.558983	0.558983
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.055405	0.413271	0.259077
Echinococcus granulosus	alpha tubulin	0.0936134	0.729156	0.729156
Leishmania major	alpha tubulin	0.0936134	0.729156	0.553469
Loa Loa (eye worm)	beta-tubulin	0.126374	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.126374	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0936134	0.729156	0.657977
Trypanosoma cruzi	tubulin delta chain	0.0530073	0.393448	0.37819
Toxoplasma gondii	beta tubulin	0.126374	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0936134	0.729156	0.657977
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0382084	0.271099	0.0795415
Schistosoma mansoni	voltage-gated potassium channel	0.0730298	0.558983	0.558983
Echinococcus granulosus	tubulin beta 4A class IVa	0.126374	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.126374	1	1
Echinococcus multilocularis	tubulin subunit beta	0.126374	1	1
Brugia malayi	hypothetical protein	0.00838512	0.0245379	0.0245379
Plasmodium falciparum	alpha tubulin 2	0.0936134	0.729156	0.657977
Loa Loa (eye worm)	hypothetical protein	0.00838512	0.0245379	0.0245379
Echinococcus multilocularis	tubulin alpha 1C chain	0.0936134	0.729156	0.729156
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0630238	0.476259	0.338618
Echinococcus multilocularis	tubulin alpha 3 chain	0.0936134	0.729156	0.729156
Leishmania major	zeta tubulin, putative	0.0679194	0.516733	0.203255
Trypanosoma brucei	epsilon tubulin	0.0724399	0.554106	0.388265
Schistosoma mansoni	organic anion transporter	0.00838512	0.0245379	0.0245379
Brugia malayi	Tubulin alpha chain	0.0936134	0.729156	0.729156
Echinococcus multilocularis	beta tubulin	0.126374	1	1
Brugia malayi	Cell division protein ftsZ	0.0305896	0.208111	0.208111
Onchocerca volvulus		0.00838512	0.0245379	0.0905124
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0936134	0.729156	0.657977
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0936134	0.729156	0.729156
Trypanosoma brucei	tubulin gamma chain	0.0724997	0.5546	0.388943
Loa Loa (eye worm)	hypothetical protein	0.00838512	0.0245379	0.0245379
Echinococcus granulosus	tubulin alpha chain	0.0936134	0.729156	0.729156
Onchocerca volvulus		0.00838512	0.0245379	0.0905124
Trichomonas vaginalis	tubulin alpha chain, putative	0.0382084	0.271099	0.0795415
Trypanosoma brucei	alpha tubulin	0.0936134	0.729156	0.628421
Plasmodium vivax	tubulin alpha chain, putative	0.0936134	0.729156	0.657977
Echinococcus granulosus	tubulin alpha 3 chain	0.0936134	0.729156	0.729156
Leishmania major	alpha tubulin	0.0936134	0.729156	0.553469
Trichomonas vaginalis	tubulin, putative	0.126374	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.126374	1	1
Giardia lamblia	Gamma tubulin	0.0724997	0.5546	0.437548
Echinococcus granulosus	Tubulin beta 2C chain	0.126374	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.126374	1	1
Trypanosoma brucei	beta tubulin	0.0687979	0.523996	0.346956
Plasmodium falciparum	tubulin gamma chain	0.0724997	0.5546	0.437548
Leishmania major	epsilon tubulin, putative	0.0724399	0.554106	0.264871
Echinococcus multilocularis	tubulin epsilon chain	0.0724399	0.554106	0.554106
Echinococcus multilocularis	tubulin beta 1 chain	0.126374	1	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0936134	0.729156	0.729156
Leishmania major	beta tubulin	0.126374	1	1
Trypanosoma brucei	tubulin delta chain	0.0530073	0.393448	0.167854
Echinococcus multilocularis	tubulin alpha 3 chain	0.0936134	0.729156	0.729156
Brugia malayi	Tubulin beta-1 chain	0.126374	1	1
Echinococcus multilocularis	beta tubulin	0.126374	1	1
Brugia malayi	beta-tubulin, identical	0.126374	1	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0342315	0.238221	0.238221
Schistosoma mansoni	alpha tubulin	0.0936134	0.729156	0.729156
Plasmodium vivax	tubulin beta chain, putative	0.126374	1	1
Leishmania major	beta tubulin	0.126374	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0936134	0.729156	0.729156
Echinococcus multilocularis	potassium voltage gated channel protein	0.0730298	0.558983	0.558983
Loa Loa (eye worm)	BEN-1 protein	0.126374	1	1
Leishmania major	beta tubulin	0.126374	1	1
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0705679	0.538629	0.538629
Leishmania major	beta tubulin	0.126374	1	1
Trichomonas vaginalis	tubulin, putative	0.0382084	0.271099	0.0795415
Brugia malayi	sodium-independent organic anion transporter family protein	0.00838512	0.0245379	0.0245379
Leishmania major	beta tubulin	0.126374	1	1
Entamoeba histolytica	tubulin family protein	0.126374	1	1
Leishmania major	beta tubulin	0.126374	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0936134	0.729156	0.657977
Loa Loa (eye worm)	tubulin gamma chain	0.0724997	0.5546	0.5546
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0630238	0.476259	0.476259
Leishmania major	beta tubulin	0.126374	1	1
Loa Loa (eye worm)	tubulin alpha 2	0.0630238	0.476259	0.476259
Echinococcus granulosus	tubulin delta chain	0.0305896	0.208111	0.208111
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.126374	1	1
Echinococcus granulosus	tubulin alpha	0.0687979	0.523996	0.523996
Trypanosoma cruzi	tubulin gamma chain	0.0724997	0.5546	0.543396
Loa Loa (eye worm)	tubulin alpha-3 chain	0.055405	0.413271	0.413271
Plasmodium vivax	tubulin alpha chain, putative	0.0936134	0.729156	0.657977
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.00838512	0.0245379	0.0245379
Schistosoma mansoni	tubulin subunit beta	0.0305896	0.208111	0.208111
Echinococcus multilocularis	tubulin alpha	0.0687979	0.523996	0.523996
Brugia malayi	tubulin alpha-2 chain	0.0936134	0.729156	0.729156
Schistosoma mansoni	tubulin subunit beta	0.126374	1	1
Plasmodium falciparum	tubulin epsilon chain, putative	0.0724399	0.554106	0.436923
Toxoplasma gondii	beta-1 tubulin, putative	0.126374	1	1
Toxoplasma gondii	transporter, major facilitator family protein	0.00838512	0.0245379	0.0245379
Loa Loa (eye worm)	hypothetical protein	0.00838512	0.0245379	0.0245379
Trichomonas vaginalis	tubulin beta chain, putative	0.0936134	0.729156	0.657977
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.00838512	0.0245379	0.0245379
Trypanosoma cruzi	epsilon tubulin, putative	0.0724399	0.554106	0.542889
Leishmania major	beta tubulin	0.126374	1	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0936134	0.729156	0.729156
Echinococcus multilocularis	tubulin alpha chain	0.0936134	0.729156	0.729156
Toxoplasma gondii	beta-tubulin, putative	0.126374	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0687979	0.523996	0.3989
Echinococcus granulosus	potassium voltage gated channel protein	0.0730298	0.558983	0.558983
Brugia malayi	Tubulin gamma chain	0.0724997	0.5546	0.5546
Loa Loa (eye worm)	tubulin beta chain	0.0305896	0.208111	0.208111
Echinococcus multilocularis	Tubulin beta 2C chain	0.126374	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0936134	0.729156	0.657977
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.00838512	0.0245379	0.0245379
Trichomonas vaginalis	tubulin alpha chain, putative	0.126374	1	1
Leishmania major	gamma-tubulin	0.0724997	0.5546	0.265686
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.00838512	0.0245379	0.0245379
Leishmania major	alpha tubulin	0.0936134	0.729156	0.553469
Giardia lamblia	Alpha-tubulin	0.0936134	0.729156	0.657977
Leishmania major	alpha tubulin	0.0936134	0.729156	0.553469
Brugia malayi	Tubulin alpha-2 chain	0.0936134	0.729156	0.729156
Trichomonas vaginalis	tubulin epsilon chain, putative	0.126374	1	1
Trypanosoma brucei	beta tubulin	0.126374	1	1
Leishmania major	alpha tubulin	0.0936134	0.729156	0.553469
Giardia lamblia	Epsilon tubulin	0.0342315	0.238221	0.0380228
Brugia malayi	Tubulin alpha chain	0.0305896	0.208111	0.208111
Plasmodium vivax	tubulin gamma chain, putative	0.0724997	0.5546	0.437548
Echinococcus multilocularis	tubulin alpha chain	0.0936134	0.729156	0.729156
Echinococcus granulosus	Solute carrier organic anion transporter family	0.00838512	0.0245379	0.0245379
Trypanosoma brucei	zeta tubulin	0.0679194	0.516733	0.336991
Onchocerca volvulus	Putative organic anion transporter	0.00838512	0.0245379	0.0905124
Echinococcus multilocularis	tubulin subunit TubB	0.0936134	0.729156	0.729156
Schistosoma mansoni	tubulin subunit beta	0.126374	1	1
Onchocerca volvulus		0.00838512	0.0245379	0.0905124
Schistosoma mansoni	tubulin subunit epsilon	0.0724399	0.554106	0.554106
Trichomonas vaginalis	tubulin alpha chain, putative	0.0382084	0.271099	0.0795415
Onchocerca volvulus		0.00838512	0.0245379	0.0905124
Echinococcus granulosus	tubulin alpha chain	0.0936134	0.729156	0.729156
Schistosoma mansoni	tubulin subunit beta	0.126374	1	1
Leishmania major	beta tubulin	0.126374	1	1
Toxoplasma gondii	alpha tubulin TUBA1	0.0936134	0.729156	0.729156
Schistosoma mansoni	tubulin subunit alpha	0.0936134	0.729156	0.729156
Loa Loa (eye worm)	tubulin beta-1 chain	0.126374	1	1
Echinococcus multilocularis	tubulin gamma 1 chain	0.0724997	0.5546	0.5546
Leishmania major	alpha tubulin	0.0936134	0.729156	0.553469
Schistosoma mansoni	voltage-gated potassium channel	0.0730298	0.558983	0.558983
Loa Loa (eye worm)	alpha-tubulin	0.0936134	0.729156	0.729156
Echinococcus granulosus	Tubulin alpha 1 chain	0.0936134	0.729156	0.729156
Schistosoma mansoni	tubulin subunit beta	0.126374	1	1
Leishmania major	beta tubulin	0.126374	1	1
Trypanosoma cruzi	alpha tubulin, putative	0.0936134	0.729156	0.722343
Schistosoma mansoni	tubulin subunit gamma	0.0724997	0.5546	0.5546
Giardia lamblia	Beta tubulin	0.126374	1	1
Leishmania major	beta tubulin	0.126374	1	1
Echinococcus granulosus	beta tubulin	0.126374	1	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0936134	0.729156	0.729156
Brugia malayi	alpha-tubulin	0.0936134	0.729156	0.729156
Trypanosoma brucei	epsilon tubulin	0.0724399	0.554106	0.388265
Trichomonas vaginalis	tubulin alpha chain, putative	0.0382084	0.271099	0.0795415
Brugia malayi	sodium-independent organic anion transporter family protein	0.00838512	0.0245379	0.0245379
Echinococcus multilocularis	hypothetical protein	0.0936134	0.729156	0.729156
Loa Loa (eye worm)	tubulin alpha 2	0.0248155	0.160374	0.160374
Trypanosoma brucei	alpha tubulin	0.0936134	0.729156	0.628421
Onchocerca volvulus	Putative organic anion transporter	0.00838512	0.0245379	0.0905124
Onchocerca volvulus		0.00838512	0.0245379	0.0905124
Leishmania major	alpha tubulin	0.0936134	0.729156	0.553469
Leishmania major	beta tubulin	0.126374	1	1
Giardia lamblia	Beta tubulin	0.126374	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0936134	0.729156	0.729156
Loa Loa (eye worm)	tubulin beta chain	0.126374	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0724997	0.5546	0.437548
Brugia malayi	sodium-independent organic anion transporter family protein	0.00838512	0.0245379	0.0245379
Toxoplasma gondii	alpha-tubulin I, putative	0.0936134	0.729156	0.729156
Leishmania major	beta tubulin	0.126374	1	1
Loa Loa (eye worm)	hypothetical protein	0.0730298	0.558983	0.558983
Trichomonas vaginalis	tubulin beta chain, putative	0.0936134	0.729156	0.657977
Echinococcus granulosus	peroxisome assembly protein 26	0.0936134	0.729156	0.729156
Leishmania major	beta tubulin	0.126374	1	1
Loa Loa (eye worm)	tubulin alpha chain	0.0936134	0.729156	0.729156
Leishmania major	alpha tubulin	0.0936134	0.729156	0.553469
Brugia malayi	Tubulin beta chain	0.0382084	0.271099	0.271099
Echinococcus granulosus	tubulin alpha chain	0.0936134	0.729156	0.729156
Echinococcus granulosus	tubulin gamma 1 chain	0.0724997	0.5546	0.5546
Echinococcus granulosus	tubulin alpha chain	0.0936134	0.729156	0.729156
Leishmania major	beta tubulin	0.126374	1	1
Echinococcus multilocularis	peroxisome assembly protein 26	0.0936134	0.729156	0.729156
Loa Loa (eye worm)	hypothetical protein	0.00838512	0.0245379	0.0245379
Leishmania major	beta tubulin	0.126374	1	1
Echinococcus granulosus	tubulin epsilon chain	0.0724399	0.554106	0.554106
Echinococcus granulosus	Tubulin alpha 1 chain	0.0936134	0.729156	0.729156
Echinococcus multilocularis	tubulin delta chain	0.0305896	0.208111	0.208111
Loa Loa (eye worm)	tubulin alpha chain	0.0936134	0.729156	0.729156
Echinococcus multilocularis	tubulin alpha chain	0.0936134	0.729156	0.729156
Loa Loa (eye worm)	hypothetical protein	0.0936134	0.729156	0.729156
Trypanosoma cruzi	beta tubulin, putative	0.126374	1	1
Schistosoma mansoni	alpha tubulin	0.0936134	0.729156	0.729156
Trypanosoma brucei	epsilon tubulin	0.0687979	0.523996	0.346956
Echinococcus multilocularis	Tubulin beta 2C chain	0.126374	1	1
Brugia malayi	prostaglandin transporter	0.00838512	0.0245379	0.0245379
Echinococcus multilocularis	Tubulin beta 2C chain	0.126374	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0382084	0.271099	0.0795415
Trypanosoma brucei	zeta tubulin, putative	0.0679194	0.516733	0.336991
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0687979	0.523996	0.523996
Schistosoma mansoni	tubulin subunit beta	0.126374	1	1
Echinococcus granulosus	tubulin subunit beta	0.126374	1	1
Schistosoma mansoni	tubulin subunit alpha	0.0936134	0.729156	0.729156
Giardia lamblia	Alpha-tubulin	0.0936134	0.729156	0.657977
Schistosoma mansoni	tubulin subunit alpha	0.0936134	0.729156	0.729156
Plasmodium falciparum	alpha tubulin 1	0.0936134	0.729156	0.657977
Echinococcus granulosus	tubulin beta 1 chain	0.126374	1	1
Treponema pallidum	cell division protein FtsZ	0.0305896	0.208111	0.5
Trypanosoma cruzi	zeta tubulin, putative	0.0679194	0.516733	0.504576
Schistosoma mansoni	tubulin subunit beta	0.126374	1	1
Trypanosoma brucei	beta tubulin	0.126374	1	1
Leishmania major	alpha tubulin	0.0936134	0.729156	0.553469
Loa Loa (eye worm)	tubulin beta-4 chain	0.126374	1	1
Brugia malayi	hypothetical protein	0.00838512	0.0245379	0.0245379
Loa Loa (eye worm)	tubulin beta-2A chain	0.126374	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0936134	0.729156	0.657977
Entamoeba histolytica	tubulin alpha-1 chain	0.0936134	0.729156	0.391908
Echinococcus granulosus	tubulin subunit TubB	0.0936134	0.729156	0.729156
Brugia malayi	Tubulin alpha-2 chain	0.0936134	0.729156	0.729156
Echinococcus granulosus	tubulin alpha 1C chain	0.0936134	0.729156	0.729156
Brugia malayi	tubulin alpha chain - mouse	0.0936134	0.729156	0.729156
Loa Loa (eye worm)	alpha-tubulin	0.0936134	0.729156	0.729156
Trypanosoma cruzi	zeta tubulin, putative	0.0679194	0.516733	0.504576
Echinococcus granulosus	Tubulin alpha 1 chain	0.0936134	0.729156	0.729156
Trypanosoma brucei	beta tubulin	0.126374	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0936134	0.729156	0.729156
Trypanosoma brucei	beta tubulin	0.126374	1	1
Leishmania major	beta tubulin	0.126374	1	1
Mycobacterium leprae	cell division protein FtsZ	0.0305896	0.208111	0.5
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0730298	0.558983	0.558983
Trypanosoma brucei	alpha tubulin	0.0936134	0.729156	0.628421
Leishmania major	alpha tubulin	0.0936134	0.729156	0.553469
Trichomonas vaginalis	tubulin beta chain, putative	0.0936134	0.729156	0.657977
Echinococcus granulosus	beta tubulin	0.126374	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.126374	1	1
Onchocerca volvulus	Putative organic anion transporter	0.00838512	0.0245379	0.0905124
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0305896	0.208111	0.5
Echinococcus granulosus	Tubulin beta 2C chain	0.126374	1	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0530073	0.393448	0.393448
Loa Loa (eye worm)	tubulin alpha 2	0.0630238	0.476259	0.476259
Loa Loa (eye worm)	hypothetical protein	0.00838512	0.0245379	0.0245379
Trypanosoma brucei	alpha tubulin	0.0936134	0.729156	0.628421
Loa Loa (eye worm)	hypothetical protein	0.00838512	0.0245379	0.0245379
Plasmodium falciparum	tubulin beta chain	0.126374	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0936134	0.729156	0.729156
Loa Loa (eye worm)	hypothetical protein	0.055405	0.413271	0.413271
Schistosoma mansoni	organic anion transporter	0.00838512	0.0245379	0.0245379
Entamoeba histolytica	tubulin family protein	0.126374	1	1
Plasmodium vivax	tubulin epsilon chain, putative	0.0724399	0.554106	0.436923
Entamoeba histolytica	tubulin alpha chain, putative	0.0936134	0.729156	0.391908
Mycobacterium ulcerans	cell division protein FtsZ	0.0305896	0.208111	0.5
Brugia malayi	Tubulin beta chain	0.0305896	0.208111	0.208111
Echinococcus granulosus	Tubulin beta 2C chain	0.126374	1	1
Leishmania major	alpha tubulin	0.0936134	0.729156	0.553469
Trypanosoma cruzi	tubulin delta chain	0.0530073	0.393448	0.37819
Onchocerca volvulus		0.0382084	0.271099	1
Trichomonas vaginalis	tubulin, putative	0.0382084	0.271099	0.0795415
Trichomonas vaginalis	tubulin beta chain, putative	0.126374	1	1
Echinococcus granulosus	tubulin alpha chain	0.0936134	0.729156	0.729156
Leishmania major	alpha tubulin	0.0936134	0.729156	0.553469
Trichomonas vaginalis	tubulin epsilon chain, putative	0.126374	1	1
Loa Loa (eye worm)	hypothetical protein	0.00838512	0.0245379	0.0245379
Schistosoma mansoni	tubulin subunit alpha	0.0305896	0.208111	0.208111
Trichomonas vaginalis	tubulin, putative	0.0342913	0.238716	0.0386472
Trichomonas vaginalis	tubulin gamma chain, putative	0.0724399	0.554106	0.436923
Loa Loa (eye worm)	hypothetical protein	0.0630238	0.476259	0.476259
Leishmania major	beta tubulin	0.126374	1	1
Schistosoma mansoni	tubulin subunit delta	0.0305896	0.208111	0.208111
Giardia lamblia	Beta tubulin	0.126374	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0936134	0.729156	0.729156
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0305896	0.208111	0.5
Schistosoma mansoni	alpha tubulin	0.0936134	0.729156	0.729156

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 23 nM	Antimalarial activity against Plasmodium falciparum NF54	ChEMBL.	22128829

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	22128829

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1945520

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1564960