TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 254.286 | Formula: C11H18N4O3
H donors: 3 H acceptors: 4 LogP: -3.77 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: N#C[C@@H]1CCCN1C(=O)CNCC(C(=O)O)(N)C
InChi: 1S/C11H18N4O3/c1-11(13,10(17)18)7-14-6-9(16)15-4-2-3-8(15)5-12/h8,14H,2-4,6-7,13H2,1H3,(H,17,18)/t8-,11?/m0/s1
InChiKey: HKKLRQWTZCSVST-YMNIQAILSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	tubulin gamma chain	0.0395	0.1459	0.4364
Giardia lamblia	Beta tubulin	0.0735	0.274	1
Loa Loa (eye worm)	BEN-1 protein	0.0735	0.274	1
Leishmania major	alpha tubulin	0.0547	0.2033	0.689
Leishmania major	beta tubulin	0.0735	0.274	1
Brugia malayi	tubulin alpha chain - mouse	0.0547	0.2033	0.7412
Echinococcus multilocularis	tubulin alpha 1C chain	0.0547	0.2033	0.7418
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0547	0.2033	0.7418
Echinococcus multilocularis	cpg binding protein	0.0031	0.0092	0.0328
Toxoplasma gondii	alpha tubulin TUBA1	0.0547	0.2033	0.7234
Trypanosoma brucei	tubulin delta chain	0.0171	0.0619	0.0668
Schistosoma mansoni	alpha tubulin	0.0547	0.2033	0.2031
Leishmania major	beta tubulin	0.0735	0.274	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0036	0.0099
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0395	0.1459	0.4987
Leishmania major	beta tubulin	0.0735	0.274	1
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0376	0.1389	0.5052
Trypanosoma brucei	epsilon tubulin	0.0395	0.1459	0.4364
Trichomonas vaginalis	tubulin gamma chain, putative	0.0395	0.1459	0.5326
Trichomonas vaginalis	tubulin, putative	0.0735	0.274	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0036	0.0122
Trichomonas vaginalis	tubulin gamma chain, putative	0.0735	0.274	1
Brugia malayi	Tubulin beta-1 chain	0.0735	0.274	1
Trypanosoma cruzi	tubulin delta chain	0.0171	0.0619	0.0668
Schistosoma mansoni	alpha tubulin	0.0547	0.2033	0.2031
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0086	0.0282
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0485	0.1798	0.1796
Plasmodium vivax	tubulin beta chain, putative	0.0735	0.274	1
Echinococcus multilocularis	tubulin subunit TubB	0.0547	0.2033	0.7418
Echinococcus granulosus	Tubulin beta 2C chain	0.0735	0.274	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0735	0.274	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0547	0.2033	0.7418
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0171	0.0619	1
Trichomonas vaginalis	tubulin, putative	0.0223	0.0815	0.2974
Echinococcus granulosus	Tubulin beta 2C chain	0.0735	0.274	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0547	0.2033	0.7418
Giardia lamblia	Beta tubulin	0.0735	0.274	1
Loa Loa (eye worm)	tubulin alpha chain	0.0547	0.2033	0.7412
Toxoplasma gondii	beta-1 tubulin, putative	0.0735	0.274	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0036	0.0122
Echinococcus granulosus	tubulin alpha 3 chain	0.0547	0.2033	0.7418
Trypanosoma brucei	beta tubulin	0.0395	0.1459	0.4364
Trichomonas vaginalis	tubulin alpha chain, putative	0.0223	0.0815	0.2974
Plasmodium vivax	tubulin gamma chain, putative	0.0395	0.1459	0.4364
Echinococcus granulosus	beta tubulin	0.0735	0.274	1
Loa Loa (eye worm)	hypothetical protein	0.0547	0.2033	0.7412
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.0167	0.0581
Echinococcus multilocularis	tubulin subunit beta	0.0735	0.274	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0735	0.274	1
Echinococcus multilocularis	dnaJ subfamily B	0.042	0.1554	0.5668
Echinococcus multilocularis	uracil DNA glycosylase	0.0131	0.0468	0.1699
Loa Loa (eye worm)	tubulin beta-2A chain	0.0735	0.274	1
Leishmania major	delta tubulin, putative	0.0171	0.0619	0.0668
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0036	0.0099
Loa Loa (eye worm)	alpha-tubulin	0.0547	0.2033	0.7412
Trichomonas vaginalis	tubulin, putative	0.0171	0.0619	0.2261
Loa Loa (eye worm)	tubulin beta chain	0.0735	0.274	1
Trypanosoma brucei	alpha tubulin	0.0547	0.2033	0.689
Schistosoma mansoni	tubulin subunit epsilon	0.0395	0.1459	0.1457
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0324	0.1193	0.4355
Entamoeba histolytica	tubulin alpha chain, putative	0.0547	0.2033	0.689
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0171	0.0619	0.2261
Trypanosoma brucei	alpha tubulin	0.0547	0.2033	0.689
Trypanosoma brucei	alpha tubulin, putative	0.0223	0.0815	0.1528
Schistosoma mansoni	hypothetical protein	0.0016	0.0036	0.0033
Brugia malayi	Uracil-DNA glycosylase	0.0131	0.0468	0.168
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0547	0.2033	0.7418
Entamoeba histolytica	tubulin gamma chain	0.0395	0.1459	0.4364
Leishmania major	alpha tubulin	0.0547	0.2033	0.689
Brugia malayi	Muscleblind-like protein	0.0153	0.0552	0.1988
Trypanosoma cruzi	epsilon tubulin, putative	0.0395	0.1459	0.4364
Echinococcus granulosus	tubulin beta 4A class IVa	0.0735	0.274	1
Entamoeba histolytica	tubulin alpha-1 chain	0.0547	0.2033	0.689
Brugia malayi	Tubulin alpha chain	0.0547	0.2033	0.7412
Loa Loa (eye worm)	hypothetical protein	0.0376	0.1389	0.5052
Echinococcus multilocularis	Tubulin beta 2C chain	0.0735	0.274	1
Brugia malayi	Tubulin beta chain	0.0171	0.0619	0.2236
Trypanosoma brucei	epsilon tubulin	0.0395	0.1459	0.4364
Leishmania major	epsilon tubulin, putative	0.0395	0.1459	0.4364
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0106	0.0358
Leishmania major	beta tubulin	0.0735	0.274	1
Echinococcus multilocularis	tubulin alpha chain	0.0547	0.2033	0.7418
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0171	0.0619	0.17
Leishmania major	beta tubulin	0.0735	0.274	1
Loa Loa (eye worm)	tubulin alpha 2	0.0153	0.0549	0.1976
Plasmodium falciparum	tubulin gamma chain	0.0395	0.1459	0.4364
Loa Loa (eye worm)	beta-tubulin	0.0735	0.274	1
Echinococcus granulosus	tubulin alpha chain	0.0547	0.2033	0.7418
Trypanosoma cruzi	alpha tubulin, putative	0.0547	0.2033	0.689
Echinococcus multilocularis	tubulin alpha 3 chain	0.0547	0.2033	0.7418
Echinococcus multilocularis	hypothetical protein	0.0547	0.2033	0.7418
Echinococcus granulosus	muscleblind protein	0.0153	0.0552	0.2006
Schistosoma mansoni	hypothetical protein	0.0016	0.0036	0.0033
Plasmodium vivax	tubulin alpha chain, putative	0.0547	0.2033	0.689
Schistosoma mansoni	G/t mismatch-specific thymine DNA glycosylase	0.0131	0.0468	0.0465
Loa Loa (eye worm)	tubulin alpha 2	0.0376	0.1389	0.5052
Schistosoma mansoni	hypothetical protein	0.0016	0.0036	0.0033
Echinococcus granulosus	tubulin alpha chain	0.0547	0.2033	0.7418
Trichomonas vaginalis	conserved hypothetical protein	0.0171	0.0619	0.2261
Trypanosoma cruzi	epsilon tubulin, putative	0.0395	0.1459	0.4364
Loa Loa (eye worm)	tubulin beta chain	0.0171	0.0619	0.2235
Trypanosoma brucei	beta tubulin	0.0735	0.274	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0036	0.0097
Trichomonas vaginalis	tubulin gamma chain, putative	0.0395	0.1459	0.5326
Trichomonas vaginalis	tubulin alpha chain, putative	0.0223	0.0815	0.2974
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0036	0.0122
Plasmodium falciparum	tubulin beta chain	0.0735	0.274	1
Echinococcus multilocularis	tubulin alpha chain	0.0547	0.2033	0.7418
Schistosoma mansoni	tubulin subunit beta	0.0735	0.274	0.2738
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.021	0.0208
Leishmania major	beta tubulin	0.0735	0.274	1
Echinococcus granulosus	tubulin gamma 1 chain	0.0395	0.1459	0.5322
Entamoeba histolytica	tubulin family protein	0.0735	0.274	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.0735	0.274	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0735	0.274	1
Mycobacterium ulcerans	cell division protein FtsZ	0.0171	0.0619	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0376	0.1389	0.5069
Echinococcus multilocularis	beta tubulin	0.0735	0.274	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0395	0.1459	0.5326
Trichomonas vaginalis	tubulin, putative	0.0223	0.0815	0.2974
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0036	0.0122
Schistosoma mansoni	tubulin subunit delta	0.0171	0.0619	0.0617
Trichomonas vaginalis	tubulin beta chain, putative	0.0223	0.0815	0.2974
Leishmania major	beta tubulin	0.0735	0.274	1
Plasmodium falciparum	tubulin epsilon chain, putative	0.0395	0.1459	0.4364
Trypanosoma brucei	epsilon tubulin	0.0395	0.1459	0.4364
Trichomonas vaginalis	tubulin beta chain, putative	0.0547	0.2033	0.7421
Trichomonas vaginalis	tubulin beta chain, putative	0.0735	0.274	1
Brugia malayi	Cell division protein ftsZ	0.0171	0.0619	0.2236
Loa Loa (eye worm)	uracil-DNA glycosylase	0.0131	0.0468	0.1678
Leishmania major	alpha tubulin	0.0547	0.2033	0.689
Echinococcus granulosus	tubulin alpha 1C chain	0.0547	0.2033	0.7418
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0106	0.0356
Schistosoma mansoni	hypothetical protein	0.0016	0.0036	0.0033
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.0167	0.0579
Schistosoma mansoni	tubulin subunit beta	0.0735	0.274	0.2738
Echinococcus granulosus	dnaJ subfamily B	0.042	0.1554	0.5668
Echinococcus granulosus	Tubulin alpha 1 chain	0.0547	0.2033	0.7418
Leishmania major	alpha tubulin	0.0547	0.2033	0.689
Schistosoma mansoni	alpha tubulin	0.0547	0.2033	0.2031
Echinococcus granulosus	tubulin alpha 1C chain	0.0547	0.2033	0.7418
Leishmania major	beta tubulin	0.0735	0.274	1
Echinococcus granulosus	uracil DNA glycosylase	0.0131	0.0468	0.1699
Leishmania major	alpha tubulin	0.0547	0.2033	0.689
Echinococcus multilocularis	tubulin beta 1 chain	0.0735	0.274	1
Loa Loa (eye worm)	tubulin gamma chain	0.0395	0.1459	0.531
Entamoeba histolytica	tubulin family protein	0.0735	0.274	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0552	0.1986
Echinococcus multilocularis	peroxisome assembly protein 26	0.0547	0.2033	0.7418
Leishmania major	beta tubulin	0.0735	0.274	1
Plasmodium falciparum	alpha tubulin 1	0.0547	0.2033	0.689
Leishmania major	beta tubulin	0.0735	0.274	1
Schistosoma mansoni	tubulin subunit beta	0.0171	0.0619	0.0617
Brugia malayi	alpha-tubulin	0.0547	0.2033	0.7412
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0552	0.1986
Echinococcus multilocularis	tubulin alpha 3 chain	0.0547	0.2033	0.7418
Schistosoma mansoni	cpg binding protein	0.0029	0.0086	0.0083
Leishmania major	beta tubulin	0.0735	0.274	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0547	0.2033	0.7421
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0036	0.0097
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0036	0.0122
Echinococcus multilocularis	tubulin epsilon chain	0.0395	0.1459	0.5322
Echinococcus granulosus	tubulin subunit TubB	0.0547	0.2033	0.7418
Trypanosoma cruzi	tubulin delta chain	0.0171	0.0619	0.0668
Echinococcus granulosus	alpha tubulin	0.0547	0.2033	0.7418
Echinococcus multilocularis	Tubulin beta 2C chain	0.0735	0.274	1
Schistosoma mansoni	tubulin subunit gamma	0.0395	0.1459	0.1457
Echinococcus multilocularis	muscleblind protein	0.0153	0.0552	0.2006
Schistosoma mansoni	tubulin subunit beta	0.0735	0.274	0.2738
Trypanosoma cruzi	beta tubulin, putative	0.0735	0.274	1
Brugia malayi	tubulin alpha-2 chain	0.0547	0.2033	0.7412
Leishmania major	gamma-tubulin	0.0395	0.1459	0.4364
Trypanosoma brucei	alpha tubulin	0.0547	0.2033	0.689
Leishmania major	alpha tubulin	0.0547	0.2033	0.689
Echinococcus multilocularis	tubulin alpha chain	0.0547	0.2033	0.7418
Treponema pallidum	cell division protein FtsZ	0.0171	0.0619	1
Schistosoma mansoni	tubulin subunit beta	0.0735	0.274	0.2738
Trichomonas vaginalis	tubulin beta chain, putative	0.0547	0.2033	0.7421
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0171	0.0619	1
Trypanosoma brucei	tubulin gamma chain	0.0395	0.1459	0.4364
Schistosoma mansoni	tubulin subunit alpha	0.0171	0.0619	0.0617
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0171	0.0619	0.2261
Schistosoma mansoni	tubulin subunit beta	0.0735	0.274	0.2738
Leishmania major	alpha tubulin	0.0547	0.2033	0.689
Schistosoma mansoni	hypothetical protein	0.042	0.1554	0.1552
Giardia lamblia	Alpha-tubulin	0.0547	0.2033	0.6667
Giardia lamblia	Gamma tubulin	0.0395	0.1459	0.3961
Toxoplasma gondii	beta tubulin	0.0735	0.274	1
Leishmania major	beta tubulin	0.0735	0.274	1
Echinococcus granulosus	GPCR family 2	0.0016	0.0036	0.0122
Schistosoma mansoni	tubulin subunit alpha	0.0547	0.2033	0.2031
Leishmania major	alpha tubulin	0.0547	0.2033	0.689
Brugia malayi	beta-tubulin, identical	0.0735	0.274	1
Leishmania major	beta tubulin	0.0735	0.274	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0547	0.2033	0.7418
Leishmania major	beta tubulin	0.0735	0.274	1
Leishmania major	alpha tubulin	0.0547	0.2033	0.689
Echinococcus granulosus	tubulin alpha	0.0395	0.1459	0.5322
Leishmania major	beta tubulin	0.0735	0.274	1
Schistosoma mansoni	tubulin subunit beta	0.0735	0.274	0.2738
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0547	0.2033	0.7412
Schistosoma mansoni	tubulin subunit alpha	0.0547	0.2033	0.2031
Leishmania major	alpha tubulin	0.0547	0.2033	0.689
Trypanosoma brucei	zeta tubulin, putative	0.0171	0.0619	0.0668
Chlamydia trachomatis	uracil DNA glycosylase	0.0131	0.0468	0.5
Echinococcus granulosus	cpg binding protein	0.0031	0.0092	0.0328
Plasmodium vivax	tubulin epsilon chain, putative	0.0395	0.1459	0.4364
Schistosoma mansoni	tubulin subunit alpha	0.0547	0.2033	0.2031
Echinococcus multilocularis	Tubulin beta 2C chain	0.0735	0.274	1
Schistosoma mansoni	uracil-DNA glycosylase	0.0131	0.0468	0.0465
Brugia malayi	Tubulin alpha-2 chain	0.0547	0.2033	0.7412
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.0167	0.0581
Loa Loa (eye worm)	tubulin alpha chain	0.0547	0.2033	0.7412
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0086	0.028
Brugia malayi	Tubulin beta chain	0.0223	0.0815	0.2951
Trypanosoma cruzi	zeta tubulin, putative	0.0171	0.0619	0.0668
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0735	0.274	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0547	0.2033	0.7421
Leishmania major	beta tubulin	0.0735	0.274	1
Plasmodium vivax	delta tubulin, putative	0.0171	0.0619	0.0668
Trichomonas vaginalis	tubulin gamma chain, putative	0.0171	0.0619	0.2261
Schistosoma mansoni	cpg binding protein	0.0031	0.0092	0.009
Echinococcus multilocularis	beta tubulin	0.0735	0.274	1
Echinococcus multilocularis	tubulin gamma 1 chain	0.0395	0.1459	0.5322
Schistosoma mansoni	hypothetical protein	0.0035	0.0106	0.0104
Trichomonas vaginalis	tubulin beta chain, putative	0.0547	0.2033	0.7421
Onchocerca volvulus		0.0223	0.0815	1
Toxoplasma gondii	uracil-DNA glycosylase	0.0131	0.0468	0.1106
Loa Loa (eye worm)	BEN-1 protein	0.0735	0.274	1
Echinococcus granulosus	peroxisome assembly protein 26	0.0547	0.2033	0.7418
Loa Loa (eye worm)	alpha-tubulin	0.0547	0.2033	0.7412
Leishmania major	zeta tubulin, putative	0.0171	0.0619	0.0668
Trichomonas vaginalis	tubulin alpha chain, putative	0.0223	0.0815	0.2974
Plasmodium falciparum	tubulin delta chain, putative	0.0171	0.0619	0.0668
Loa Loa (eye worm)	tubulin beta-4 chain	0.0735	0.274	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0547	0.2033	0.7418
Trypanosoma brucei	beta tubulin	0.0735	0.274	1
Echinococcus granulosus	tubulin delta chain	0.0171	0.0619	0.2254
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0547	0.2033	0.7421
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0223	0.0815	0.2974
Trichomonas vaginalis	conserved hypothetical protein	0.0171	0.0619	0.2261
Leishmania major	beta tubulin	0.0735	0.274	1
Mycobacterium leprae	cell division protein FtsZ	0.0171	0.0619	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0009	0.0025
Echinococcus granulosus	tubulin epsilon chain	0.0395	0.1459	0.5322
Echinococcus multilocularis	tubulin delta chain	0.0171	0.0619	0.2254
Echinococcus multilocularis	tubulin alpha chain	0.0547	0.2033	0.7418
Trichomonas vaginalis	tubulin beta chain, putative	0.0547	0.2033	0.7421
Echinococcus granulosus	tubulin alpha chain	0.0547	0.2033	0.7418
Brugia malayi	Tubulin alpha-2 chain	0.0547	0.2033	0.7412
Schistosoma mansoni	cpg binding protein	0.0031	0.0092	0.009
Echinococcus granulosus	tubulin beta 1 chain	0.0735	0.274	1
Trypanosoma brucei	zeta tubulin	0.0171	0.0619	0.0668
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0735	0.274	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0167	0.0579
Echinococcus multilocularis	tubulin alpha	0.0395	0.1459	0.5322
Echinococcus granulosus	Tubulin beta 2C chain	0.0735	0.274	1
Loa Loa (eye worm)	hypothetical protein	0.0324	0.1193	0.4336
Plasmodium falciparum	alpha tubulin 2	0.0547	0.2033	0.689
Echinococcus multilocularis	tubulin alpha chain	0.0547	0.2033	0.7418
Trichomonas vaginalis	uracil DNA glycosylase, putative	0.0131	0.0468	0.1706
Echinococcus granulosus	Tubulin beta 2C chain	0.0735	0.274	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0547	0.2033	0.7418
Echinococcus granulosus	tubulin alpha chain	0.0547	0.2033	0.7418
Echinococcus granulosus	tubulin alpha chain	0.0547	0.2033	0.7418
Echinococcus granulosus	tubulin subunit beta	0.0735	0.274	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0735	0.274	1
Echinococcus granulosus	beta tubulin	0.0735	0.274	1
Giardia lamblia	Alpha-tubulin	0.0547	0.2033	0.6667
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0009	0.0025
Loa Loa (eye worm)	tubulin alpha 2	0.0376	0.1389	0.5052
Giardia lamblia	Beta tubulin	0.0735	0.274	1
Trypanosoma cruzi	zeta tubulin, putative	0.0171	0.0619	0.0668
Leishmania major	alpha tubulin	0.0547	0.2033	0.689
Trypanosoma brucei	beta tubulin	0.0735	0.274	1
Trypanosoma brucei	beta tubulin	0.0735	0.274	1
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0324	0.1193	0.4336
Toxoplasma gondii	alpha-tubulin I, putative	0.0547	0.2033	0.7234
Trichomonas vaginalis	tubulin beta chain, putative	0.0547	0.2033	0.7421
Trypanosoma brucei	alpha tubulin	0.0547	0.2033	0.689
Leishmania major	beta tubulin	0.0735	0.274	1
Echinococcus multilocularis	muscleblind protein 1	0.0153	0.0552	0.2006
Brugia malayi	Tubulin alpha chain	0.0171	0.0619	0.2236
Trichomonas vaginalis	tubulin beta chain, putative	0.0547	0.2033	0.7421
Toxoplasma gondii	beta-tubulin, putative	0.0735	0.274	1
Brugia malayi	Tubulin gamma chain	0.0395	0.1459	0.5311
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0171	0.0619	0.17
Leishmania major	alpha tubulin	0.0547	0.2033	0.689
Plasmodium vivax	tubulin alpha chain, putative	0.0547	0.2033	0.689
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0735	0.274	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 109000 nM	Inhibition of human dipeptidyl peptidase IV (DPP IV) obtained from human colonic carcinoma cells	ChEMBL.	12801240
IC50 (binding)	= 109000 nM	Inhibition of human dipeptidyl peptidase IV (DPP IV) obtained from human colonic carcinoma cells	ChEMBL.	12801240

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 156914