TDR Targets

Basic information

Technical information

TDR Targets ID: 1575005
Name: 2-[4-[6-[[6-[2-[(2-chloro-6-methylphenyl)amin o]benzimidazol-1-yl]pyrimidin-4-yl]amino]-2-m ethylpyrimidin-4-yl]piperazin-1-yl]ethanol
MW: 571.076 | Formula: C29H31ClN10O
H donors: 3 H acceptors: 6 LogP: 5.05 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: OCCN1CCN(CC1)c1cc(Nc2ncnc(c2)n2c(Nc3c(C)cccc3Cl)nc3c2cccc3)nc(n1)C
InChi: 1S/C29H31ClN10O/c1-19-6-5-7-21(30)28(19)37-29-35-22-8-3-4-9-23(22)40(29)26-16-24(31-18-32-26)36-25-17-27(34-20(2)33-25)39-12-10-38(11-13-39)14-15-41/h3-9,16-18,41H,10-15H2,1-2H3,(H,35,37)(H,31,32,33,34,36)
InChiKey: ZFGRQAXIHZXQBZ-UHFFFAOYSA-N

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[4-[6-[[6-[2-[(2-chloro-6-methyl-phenyl)amino]benzimidazol-1-yl]pyrimidin-4-yl]amino]-2-methyl-pyrimidin-4-yl]piperazin-1-yl]ethanol
2-[4-[6-[[6-[2-[(2-chloro-6-methylphenyl)amino]-1-benzimidazolyl]-4-pyrimidinyl]amino]-2-methyl-4-pyrimidinyl]-1-piperazinyl]ethanol

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	LYN proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References
Homo sapiens	insulin receptor	Starlite/ChEMBL	References
Homo sapiens	LCK proto-oncogene, Src family tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08252 receptor protein-tyrosine kinase [EC2.7.10.1], putative	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus granulosus	insulin receptor	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Insulin-like peptide receptor precursor, putative	Get druggable targets OG5_129857	All targets in OG5_129857
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	insulin growth factor 1 receptor beta	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	insulin receptor	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	IPR008957,Fibronectin, type III-like fold,domain-containing	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K04527 insulin receptor, putative	Get druggable targets OG5_129857	All targets in OG5_129857
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_129857	All targets in OG5_129857
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Insulin-like peptide receptor precursor, putative	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus multilocularis	insulin growth factor 1 receptor beta	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129857	All targets in OG5_129857
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_129857	All targets in OG5_129857
Loa Loa (eye worm)	TK/INSR protein kinase	Get druggable targets OG5_129857	All targets in OG5_129857
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0022	0.0023	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0022	0.0023	0.0025
Echinococcus multilocularis	G protein coupled receptor 139	0.0022	0.0023	0.0025
Schistosoma mansoni	sodium/chloride dependent transporter	0.0029	0.0041	0.0045
Echinococcus multilocularis	serotonin receptor	0.0022	0.0023	0.0025
Schistosoma mansoni	opsin-like receptor	0.0022	0.0023	0.0025
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0029	0.0041	0.0045
Echinococcus granulosus	orexin receptor type 2	0.0022	0.0023	0.0025
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0022	0.0023	0.0021
Schistosoma mansoni	hypothetical protein	0.0022	0.0023	0.0025
Loa Loa (eye worm)	TK protein kinase	0.0055	0.0111	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0023	0.0025
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.3686	1	0.5
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0022	0.0023	0.0025
Loa Loa (eye worm)	melatonin receptor type 1A	0.0022	0.0023	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Brugia malayi	G-protein coupled receptor	0.0022	0.0023	0.0007
Echinococcus multilocularis	neuropeptide Y receptor	0.0022	0.0023	0.0025
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0055	0.0111	0.0123
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.0015	0.0013
Schistosoma mansoni	neuropeptide F-like receptor	0.0022	0.0023	0.0025
Brugia malayi	Dopamine receptor protein 1	0.0022	0.0023	0.0007
Brugia malayi	Sex muscle abnormal protein 5	0.0027	0.0035	0.002
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0022	0.0023	0.0025
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0022	0.0023	0.0025
Brugia malayi	SRC-1	0.0068	0.0148	0.0132
Schistosoma mansoni	amine GPCR	0.0022	0.0023	0.0025
Schistosoma mansoni	amine GPCR	0.0022	0.0023	0.0025
Echinococcus multilocularis	neuropeptide Y receptor	0.0022	0.0023	0.0025
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0023	0.0025
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0033	0.0052	0.0057
Loa Loa (eye worm)	hypothetical protein	0.002	0.0015	0.0013
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0029	0.0041	0.0045
Echinococcus multilocularis	tyrosine kinase	0.002	0.0015	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0427	0.0425
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.0015	0.0013
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0023	0.0025
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0213	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0427	0.0425
Brugia malayi	Serotonin receptor	0.0022	0.0023	0.0007
Schistosoma mansoni	tyrosine kinase	0.0077	0.0171	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0022	0.0023	0.0025
Schistosoma mansoni	opsin-like receptor	0.0022	0.0023	0.0025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0023	0.0025
Onchocerca volvulus		0.0022	0.0023	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0022	0.0023	0.0025
Echinococcus multilocularis	serotonin receptor	0.0022	0.0023	0.0025
Echinococcus multilocularis		0.0021	0.0018	0.002
Leishmania major	C-8 sterol isomerase-like protein	0.3686	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0023	0.0025
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0068	0.0148	0.0163
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0023	0.0025
Schistosoma mansoni	tyrosine kinase	0.0068	0.0148	0.0163
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.0023	0.0025
Brugia malayi	larval opioid receptor	0.0022	0.0023	0.0007
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.0015	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0029	0.0041	0.0045
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0041	0.0074	0.0082
Echinococcus granulosus	epidermal growth factor receptor	0.0077	0.0171	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0041	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0023	0.0025
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0068	0.0148	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Onchocerca volvulus		0.0022	0.0023	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0041	0.0038
Onchocerca volvulus	Tyrosine kinase homolog	0.0176	0.044	0.047
Brugia malayi	Melatonin receptor type 1A	0.0022	0.0023	0.0007
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0029	0.0041	0.0045
Echinococcus multilocularis	fmrfamide receptor	0.0022	0.0023	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0018	0.0012	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0023	0.0025
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.0015	0.0013
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0023	0.0025
Echinococcus multilocularis	nmda type glutamate receptor	0.0026	0.0031	0.0035
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0068	0.0148	0.0163
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0068	0.0148	0.0163
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0022	0.0023	0.0007
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0029	0.0041	0.5
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0022	0.0023	0.0008
Echinococcus granulosus	tyrosine kinase	0.0055	0.0111	0.0123
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0029	0.0041	0.0045
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0022	0.0023	0.0025
Echinococcus granulosus	sodium and chloride dependent glycine	0.0029	0.0041	0.0045
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0029	0.0041	0.5
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0022	0.0023	0.0021
Schistosoma mansoni	tyrosine kinase	0.0077	0.0171	0.0189
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0023	0.0025
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.0015	0.0013
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0033	0.0052	0.0057
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0018	0.0012	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0068	0.0148	0.0163
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0029	0.0041	0.0045
Schistosoma mansoni	amine GPCR	0.0022	0.0023	0.0025
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.0015	0.0013
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0068	0.0148	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0027	0.0035	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0427	0.0425
Brugia malayi	Tyrosine-protein kinase abl-1	0.0033	0.0052	0.0036
Schistosoma mansoni	adapter molecule crk	0.0027	0.0035	0.0039
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0022	0.0023	0.0025
Schistosoma mansoni	sodium/chloride dependent transporter	0.0029	0.0041	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Brugia malayi	hypothetical protein	0.0022	0.0023	0.0007
Echinococcus granulosus	neuropeptides capa receptor	0.0022	0.0023	0.0025
Loa Loa (eye worm)	norepinephrine transporter	0.0171	0.0427	0.0425
Echinococcus granulosus	tyrosine protein kinase HCK	0.0041	0.0074	0.0082
Echinococcus granulosus	neuropeptide s receptor	0.0022	0.0023	0.0025
Onchocerca volvulus		0.0029	0.0041	0.0028
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0022	0.0023	0.0025
Schistosoma mansoni	tyrosine kinase	0.0077	0.0171	0.0189
Schistosoma mansoni	hypothetical protein	0.0022	0.0023	0.0025
Echinococcus granulosus	growth factor receptor bound protein 2	0.0027	0.0035	0.0039
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0022	0.0023	0.0007
Loa Loa (eye worm)	TK/INSR protein kinase	0.0163	0.0405	0.0403
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0068	0.0148	0.0163
Brugia malayi	hypothetical protein	0.0022	0.0023	0.0007
Echinococcus granulosus	neuropeptides capa receptor	0.0022	0.0023	0.0025
Onchocerca volvulus		0.0029	0.0041	0.0028
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0022	0.0023	0.0007
Echinococcus granulosus	sex peptide receptor	0.0022	0.0023	0.0025
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0022	0.0023	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Schistosoma mansoni	nck2/grb4	0.0027	0.0035	0.0039
Schistosoma mansoni	amine GPCR	0.0022	0.0023	0.0025
Echinococcus granulosus	neuropeptide receptor A26	0.0022	0.0023	0.0025
Brugia malayi	vesicular acetylcholine transporter unc-17	0.3338	0.9051	0.905
Loa Loa (eye worm)	serotonin transporter b	0.0171	0.0427	0.0425
Onchocerca volvulus		0.0022	0.0023	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0018	0.001	0.0008
Entamoeba histolytica	protein kinase, putative	0.0041	0.0074	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0022	0.0023	0.0008
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0068	0.0148	0.0163
Brugia malayi	hypothetical protein	0.0022	0.0023	0.0007
Echinococcus multilocularis	conserved hypothetical protein	0.0768	0.2052	0.2267
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0029	0.0041	0.0045
Schistosoma mansoni	tyrosine kinase	0.0163	0.0405	0.0448
Echinococcus granulosus	neuropeptide receptor	0.0022	0.0023	0.0025
Echinococcus granulosus	sodium and chloride dependent glycine	0.0029	0.0041	0.0045
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0026	0.0031	0.0035
Onchocerca volvulus		0.0022	0.0023	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Echinococcus granulosus	serotonin transporter	0.0171	0.0427	0.0471
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0023	0.0025
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0023	0.0025
Brugia malayi	Serotonin receptor	0.0534	0.1416	0.1403
Onchocerca volvulus		0.0022	0.0023	0.0008
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0029	0.0041	0.0045
Onchocerca volvulus		0.0022	0.0023	0.0008
Onchocerca volvulus		0.0022	0.0023	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0068	0.0148	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Onchocerca volvulus		0.0022	0.0023	0.0008
Brugia malayi	putative neuropeptide receptor	0.0022	0.0023	0.0007
Onchocerca volvulus		0.0022	0.0023	0.0008
Schistosoma mansoni	tyrosine kinase	0.0033	0.0052	0.0057
Onchocerca volvulus		0.0022	0.0023	0.0008
Echinococcus multilocularis	neuropeptide receptor A26	0.0022	0.0023	0.0025
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0188	0.0473	0.0458
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0188	0.0473	0.0471
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0022	0.0023	0.0025
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0029	0.0041	0.0025
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0022	0.0023	0.0025
Echinococcus granulosus	G protein coupled receptor 139	0.0022	0.0023	0.0025
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0022	0.0023	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Echinococcus granulosus	serotonin receptor	0.0022	0.0023	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0022	0.0023	0.0025
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0068	0.0148	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Brugia malayi	Protein kinase domain containing protein	0.0163	0.0405	0.0391
Toxoplasma gondii	hypothetical protein	0.0029	0.0041	0.5
Brugia malayi	neuropeptide F receptor	0.0022	0.0023	0.0007
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.0015	0.0013
Toxoplasma gondii	hypothetical protein	0.0029	0.0041	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.0022	0.0023	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Loa Loa (eye worm)	neuropeptide F receptor	0.0022	0.0023	0.0021
Schistosoma mansoni	tyrosine kinase	0.0163	0.0405	0.0448
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0029	0.0041	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0077	0.0171	0.0189
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0055	0.0111	0.0123
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0068	0.0148	0.0163
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0027	0.0035	0.0039
Loa Loa (eye worm)	neuropeptide F receptor	0.0022	0.0023	0.0021
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0022	0.0023	0.0025
Brugia malayi	hypothetical protein	0.0029	0.0041	0.0025
Loa Loa (eye worm)	TK/ABL protein kinase	0.002	0.0015	0.0013
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0029	0.0041	0.0025
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0023	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Echinococcus granulosus	NCK adaptor protein	0.0027	0.0035	0.0039
Brugia malayi	hypothetical protein	0.0022	0.0023	0.0007
Brugia malayi	G protein-coupled receptor F59B2.13	0.0022	0.0023	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0018	0.001	0.0008
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0022	0.0023	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0023	0.0025
Brugia malayi	Variant SH3 domain containing protein	0.0027	0.0035	0.002
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0022	0.0023	0.0007
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0055	0.0111	0.0123
Schistosoma mansoni	neuropeptide f receptor 76f	0.0022	0.0023	0.0025
Brugia malayi	G-protein coupled receptor	0.0022	0.0023	0.0007
Echinococcus granulosus	roundabout 2	0.0018	0.001	0.0011
Brugia malayi	ORL1-like opioid receptor	0.0022	0.0023	0.0007
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0033	0.0052	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Echinococcus granulosus	epidermal growth factor receptor	0.0077	0.0171	0.0189
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0029	0.0041	0.0045
Echinococcus multilocularis	vesicular acetylcholine transporter	0.3338	0.9051	1
Onchocerca volvulus		0.0022	0.0023	0.0008
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0544	0.1444	0.1596
Loa Loa (eye worm)	G-protein coupled receptor	0.0022	0.0023	0.0021
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0068	0.0148	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0041	0.0038
Echinococcus multilocularis	allatostatin A receptor	0.0022	0.0023	0.0025
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0041	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0027	0.0035	0.0033
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0068	0.0148	0.0163
Brugia malayi	Variant SH3 domain containing protein	0.0027	0.0035	0.002
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0171	0.0427	0.0412
Schistosoma mansoni	tyrosine kinase	0.0033	0.0052	0.0057
Echinococcus granulosus	tyrosine protein kinase Blk	0.0055	0.0111	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0041	0.0038
Onchocerca volvulus		0.0167	0.0415	0.0443
Brugia malayi	hypothetical protein	0.0022	0.0023	0.0007
Echinococcus multilocularis	neuropeptides capa receptor	0.0022	0.0023	0.0025
Plasmodium falciparum	amino acid transporter, putative	0.0029	0.0041	0.5
Onchocerca volvulus		0.0029	0.0041	0.0028
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0023	0.0025
Schistosoma mansoni	tyrosine kinase	0.002	0.0015	0.0017
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0023	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0022	0.0023	0.0025
Schistosoma mansoni	tyrosine kinase	0.0068	0.0148	0.0163
Echinococcus granulosus	g-protein coupled receptor	0.0022	0.0023	0.0025
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0023	0.0025
Echinococcus granulosus	nmda type glutamate receptor	0.0026	0.0031	0.0035
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0014	0.0016
Echinococcus multilocularis	neuropeptides capa receptor	0.0022	0.0023	0.0025
Echinococcus multilocularis	epidermal growth factor receptor	0.0077	0.0171	0.0189
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0027	0.0035	0.0039
Schistosoma mansoni	tyrosine kinase	0.0071	0.0154	0.017
Schistosoma mansoni	myosin xvIII	0.0022	0.0023	0.0025
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0163	0.0405	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0029	0.0041	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0041	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0196	0.0194
Echinococcus granulosus	hypothetical protein	0.079	0.2113	0.2335
Onchocerca volvulus		0.0022	0.0023	0.0008
Echinococcus multilocularis	sex peptide receptor	0.0022	0.0023	0.0025
Schistosoma mansoni	vesicular amine transporter	0.0017	0.0009	0.001
Schistosoma mansoni	neuropeptide F-like receptor	0.0022	0.0023	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0041	0.0038
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0022	0.0023	0.0025
Trypanosoma brucei	C-8 sterol isomerase, putative	0.3686	1	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.0015	0.0013
Echinococcus granulosus	tyrosine protein kinase shark	0.002	0.0015	0.0017
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0049	0.0095	0.0105
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0022	0.0023	0.0025
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0033	0.0052	0.0057
Schistosoma mansoni	tyrosine kinase	0.002	0.0015	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0023	0.0025
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0029	0.0041	0.0045
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0022	0.0023	0.0025
Echinococcus multilocularis	neuropeptide receptor	0.0022	0.0023	0.0025
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0029	0.0041	0.0045
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0022	0.0023	0.0025
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0023	0.0025
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0029	0.0041	0.0025
Loa Loa (eye worm)	TK protein kinase	0.0041	0.0074	0.0072
Echinococcus granulosus	7tm_1 domain containing protein	0.0022	0.0023	0.0025
Echinococcus granulosus	tyrosine protein kinase Srms	0.002	0.0015	0.0017
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0023	0.0025
Brugia malayi	hypothetical protein	0.0022	0.0023	0.0007
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0029	0.0041	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.002	0.0015	0.0017
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0029	0.0041	0.0045
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0022	0.0023	0.0021
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0022	0.0023	0.0021
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.0023	0.0025
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0022	0.0023	0.0025
Schistosoma mansoni	hypothetical protein	0.0022	0.0023	0.0025
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0022	0.0023	0.0025
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0029	0.0041	0.0038
Echinococcus multilocularis	NCK adaptor protein	0.0027	0.0035	0.0039
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0029	0.0041	0.0045
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0023	0.0025
Echinococcus granulosus	dro:myosuppressin receptor	0.0022	0.0023	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0055	0.0111	0.0123
Loa Loa (eye worm)	G-protein coupled receptor	0.0022	0.0023	0.0021
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0068	0.0148	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0022	0.0023	0.0025
Schistosoma mansoni	cell adhesion molecule	0.0015	0.0002	0.0002
Echinococcus granulosus	biogenic amine 5HT receptor	0.0022	0.0023	0.0025
Echinococcus granulosus	tm gpcr rhodopsin	0.0022	0.0023	0.0025
Schistosoma mansoni	histamine h1 receptor	0.0022	0.0023	0.0025
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0029	0.0041	0.0025
Echinococcus granulosus	insulin receptor	0.0163	0.0405	0.0448
Brugia malayi	AKH receptor	0.0022	0.0023	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Echinococcus multilocularis	roundabout 2	0.0018	0.001	0.0011
Brugia malayi	Dopamine receptor	0.0022	0.0023	0.0007
Onchocerca volvulus		0.0022	0.0023	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0035	0.0033
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0029	0.0041	0.0038
Schistosoma mansoni	hypothetical protein	0.0022	0.0023	0.0025
Schistosoma mansoni	vesicular acetylcholine transporter	0.3338	0.9051	1
Echinococcus granulosus	neuropeptide Y receptor	0.0022	0.0023	0.0025
Echinococcus granulosus	biogenic amine 5HT receptor	0.0022	0.0023	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0022	0.0023	0.0025
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0077	0.0171	0.0169
Echinococcus granulosus	tyrosine kinase	0.002	0.0015	0.0017
Schistosoma mansoni	growth factor receptor-bound protein	0.0027	0.0035	0.0039
Schistosoma mansoni	tyrosine kinase	0.0071	0.0154	0.017
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0023	0.0025
Brugia malayi	hypothetical protein	0.0022	0.0023	0.0007
Brugia malayi	sulfakinin receptor protein	0.0022	0.0023	0.0007
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0171	0.0427	0.0425
Echinococcus granulosus	neuropeptide receptor	0.0022	0.0023	0.0025
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0023	0.0025
Echinococcus granulosus	neuropeptide Y receptor	0.0022	0.0023	0.0025
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0029	0.0041	0.0045
Loa Loa (eye worm)	TYRA-2 protein	0.0022	0.0023	0.0021
Onchocerca volvulus		0.0022	0.0023	0.0008
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0022	0.0023	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Echinococcus granulosus	rhodopsin orphan GPCR	0.0022	0.0023	0.0025
Echinococcus granulosus	tyrosine protein kinase ABL1	0.002	0.0015	0.0017
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0023	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Onchocerca volvulus		0.0022	0.0023	0.0008
Loa Loa (eye worm)	hypothetical protein	0.3686	1	1
Loa Loa (eye worm)	SRC-1	0.0068	0.0148	0.0145
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0029	0.0041	0.0045
Echinococcus multilocularis	fmrfamide receptor	0.0022	0.0023	0.0025
Onchocerca volvulus		0.0022	0.0023	0.0008
Echinococcus multilocularis	neuropeptide receptor	0.0022	0.0023	0.0025
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0049	0.0095	0.0105
Echinococcus multilocularis	g-protein coupled receptor	0.0022	0.0023	0.0025
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0023	0.0025
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.002	0.0015	0.0017
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.0002	0.0002
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.0015	0.0013
Brugia malayi	hypothetical protein	0.0022	0.0023	0.0007
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0023	0.0025
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0022	0.0023	0.0007
Echinococcus granulosus	fmrfamide receptor	0.0022	0.0023	0.0025
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0068	0.0148	0.0163
Brugia malayi	protein-tyrosine kinase	0.0055	0.0111	0.0096
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0022	0.0023	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Brugia malayi	neuropeptide F receptor	0.0022	0.0023	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Echinococcus granulosus	tm gpcr rhodopsin	0.0544	0.1444	0.1596
Loa Loa (eye worm)	TK/FER protein kinase	0.002	0.0015	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0041	0.0038
Brugia malayi	G protein-coupled receptor	0.0022	0.0023	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Plasmodium vivax	amine transporter, putative	0.0029	0.0041	0.5
Brugia malayi	follicle stimulating hormone receptor	0.0022	0.0023	0.0007
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0029	0.0041	0.0045
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0023	0.0025
Onchocerca volvulus		0.0022	0.0023	0.0008
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.002	0.0015	0.0017
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0022	0.0023	0.0025
Echinococcus multilocularis	g protein coupled receptor	0.0022	0.0023	0.0025
Echinococcus multilocularis	orexin receptor type 2	0.0022	0.0023	0.0025
Brugia malayi	hypothetical protein	0.0022	0.0023	0.0007
Treponema pallidum	sodium- and chloride- dependent transporter	0.0171	0.0427	1
Echinococcus multilocularis	somatostatin receptor	0.0022	0.0023	0.0025
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0022	0.0023	0.0025
Echinococcus granulosus	somatostatin receptor	0.0022	0.0023	0.0025
Brugia malayi	hypothetical protein	0.0022	0.0023	0.0007
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0022	0.0023	0.0025
Plasmodium falciparum	transporter, putative	0.0029	0.0041	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0068	0.0148	0.0163
Echinococcus multilocularis	serotonin transporter	0.0171	0.0427	0.0471
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0023	0.0025
Schistosoma mansoni	sodium/chloride dependent transporter	0.0171	0.0427	0.0471
Schistosoma mansoni	opsin-like receptor	0.0022	0.0023	0.0025
Echinococcus multilocularis	tyrosine protein kinase shark	0.002	0.0015	0.0017
Echinococcus granulosus	g protein coupled receptor	0.0022	0.0023	0.0025
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0022	0.0023	0.0025
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0171	0.0427	0.0471
Echinococcus granulosus	allatostatin A receptor	0.0022	0.0023	0.0025
Echinococcus granulosus	c src tyrosine kinase	0.0033	0.0052	0.0057
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0023	0.0025
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0023	0.0025
Echinococcus granulosus	neuropeptide FF receptor 2	0.0022	0.0023	0.0025
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0163	0.0405	0.0448
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0029	0.0041	0.0045
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.3338	0.9051	0.9051
Brugia malayi	RE15519p	0.0022	0.0023	0.0007
Echinococcus multilocularis	c src tyrosine kinase	0.0033	0.0052	0.0057
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0023	0.0025
Echinococcus multilocularis	epidermal growth factor receptor	0.0077	0.0171	0.0189
Schistosoma mansoni	adenoreceptor	0.0022	0.0023	0.0025
Echinococcus multilocularis	dro:myosuppressin receptor	0.0022	0.0023	0.0025
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0068	0.0148	0.0163
Loa Loa (eye worm)	hypothetical protein	0.1791	0.484	0.4839
Brugia malayi	Dopamine receptor protein 2	0.0022	0.0023	0.0007
Brugia malayi	Furin-like cysteine rich region family protein	0.0077	0.0171	0.0156
Echinococcus multilocularis	insulin receptor	0.0163	0.0405	0.0448
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0023	0.0025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0022	0.0023	0.0025
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0022	0.0023	0.0025
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0022	0.0023	0.0025
Schistosoma mansoni	amine GPCR	0.0022	0.0023	0.0025
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0022	0.0023	0.0025
Schistosoma mansoni	neuropeptide receptor	0.0022	0.0023	0.0025
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0022	0.0023	0.0025
Schistosoma mansoni	growth factor receptor-bound protein	0.0027	0.0035	0.0039
Schistosoma mansoni	tyrosine kinase	0.0071	0.0154	0.017
Echinococcus granulosus	7TM GPCR rhodopsin	0.0022	0.0023	0.0025
Echinococcus granulosus	vesicular acetylcholine transporter	0.3338	0.9051	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0022	0.0023	0.0025
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0022	0.0023	0.0025
Brugia malayi	GnHR receptor homolog	0.0022	0.0023	0.0007
Brugia malayi	putative neuropeptide receptor NPR1	0.0022	0.0023	0.0007
Onchocerca volvulus		0.0171	0.0427	0.0455
Echinococcus multilocularis	neuropeptide s receptor	0.0022	0.0023	0.0025
Schistosoma mansoni	biogenic amine receptor	0.0022	0.0023	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0023	0.0021
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0022	0.0023	0.0007
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.3338	0.9051	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0022	0.0023	0.0025

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.005 uM	Inhibition of TEL fused Src-mediated proliferation of TEL-Src transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assay	ChEMBL.	18793846
IC50 (binding)	= 0.007 uM	Inhibition of TEL fused Lck-mediated proliferation of TEL-Lck transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assay	ChEMBL.	18793846
IC50 (binding)	= 0.025 uM	Inhibition of Lck by lance assay	ChEMBL.	18793846
IC50 (binding)	= 0.03 uM	Inhibition of TEL fused Lyn-mediated proliferation of TEL-Lyn transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assay	ChEMBL.	18793846
IC50 (binding)	= 0.356 uM	Inhibition of TEL fused KDR-mediated proliferation of TEL-KDR transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assay	ChEMBL.	18793846
IC50 (binding)	= 2.345 uM	Inhibition of TEL fused InsR-mediated proliferation of TEL-InsR transformed mouse BA/F3 cells after 48 hrs by bright-glo luciferase assay	ChEMBL.	18793846

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL447107

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1575005