Detailed information for compound 1583275

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 413.596 | Formula: C25H39N3O2
  • H donors: 2 H acceptors: 1 LogP: 5.4 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=N)C1(CC1)C(=O)Nc1ccc(cc1)CCCCCCCOCC1CCCCC1
  • InChi: 1S/C25H39N3O2/c26-23(27)25(16-17-25)24(29)28-22-14-12-20(13-15-22)9-5-2-1-3-8-18-30-19-21-10-6-4-7-11-21/h12-15,21H,1-11,16-19H2,(H3,26,27)(H,28,29)
  • InChiKey: GIEQSPDHXIEAPU-UHFFFAOYSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tubulin alpha 0.0163 0.3789 0.3748
Giardia lamblia Alpha-tubulin 0.0215 0.5126 0.6504
Schistosoma mansoni chromobox protein 0.0023 0.0245 0.0182
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0245 0.0182
Echinococcus multilocularis Tubulin beta 2C chain 0.0321 0.7816 0.7802
Plasmodium falciparum alpha tubulin 1 0.0215 0.5126 0.6504
Trichomonas vaginalis tubulin gamma chain, putative 0.0071 0.1456 0.1735
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0333 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.107 0.1234
Echinococcus granulosus tubulin alpha chain 0.0215 0.5126 0.5094
Echinococcus granulosus Tubulin beta 2C chain 0.0321 0.7816 0.7802
Onchocerca volvulus 0.0092 0.1999 0.3198
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0245 0.0182
Trypanosoma cruzi tubulin delta chain 0.0071 0.1456 0.1735
Brugia malayi Tubulin alpha chain 0.0071 0.1456 0.1863
Toxoplasma gondii beta-tubulin, putative 0.0321 0.7816 1
Schistosoma mansoni tubulin subunit delta 0.0071 0.1456 0.1401
Schistosoma mansoni tubulin subunit alpha 0.0071 0.1456 0.1401
Trypanosoma brucei epsilon tubulin 0.0163 0.3789 0.4766
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1969 0.1917
Trypanosoma cruzi epsilon tubulin, putative 0.0163 0.3789 0.4766
Trichomonas vaginalis chromobox protein, putative 0.0084 0.18 0.2182
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1425 0.1369
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0245 0.0162
Plasmodium falciparum tubulin epsilon chain, putative 0.0163 0.3789 0.4766
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0409 0.0375
Trypanosoma brucei alpha tubulin, putative 0.0092 0.1999 0.244
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1425 0.1369
Trichomonas vaginalis tubulin alpha chain, putative 0.0092 0.1999 0.244
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0245 0.0162
Schistosoma mansoni tubulin subunit beta 0.0321 0.7816 0.7802
Brugia malayi SET domain containing protein 0.0025 0.0289 0.037
Echinococcus granulosus Tubulin beta 2C chain 0.0321 0.7816 0.7802
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0444 0.0382
Loa Loa (eye worm) hypothetical protein 0.005 0.0925 0.1111
Loa Loa (eye worm) hypothetical protein 0.0023 0.0245 0.0233
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0979 0.1115
Trypanosoma brucei alpha tubulin 0.0215 0.5126 0.6504
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0245 0.0162
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0245 0.0162
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0979 0.1179
Leishmania major trypanothione reductase 0.0052 0.0979 0.1115
Trichomonas vaginalis tubulin beta chain, putative 0.0215 0.5126 0.6504
Brugia malayi beta-tubulin, identical 0.0321 0.7816 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0409 0.0375
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.705 0.9005
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.0245 0.0162
Schistosoma mansoni chromobox protein 0.0023 0.0245 0.0182
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0078 0.165 0.2561
Echinococcus granulosus Tubulin alpha 1 chain 0.0215 0.5126 0.5094
Trypanosoma cruzi beta tubulin, putative 0.0321 0.7816 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0092 0.1999 0.244
Toxoplasma gondii beta-1 tubulin, putative 0.0321 0.7816 1
Echinococcus granulosus tubulin subunit TubB 0.0215 0.5126 0.5094
Schistosoma mansoni tubulin subunit beta 0.0321 0.7816 0.7802
Echinococcus multilocularis Tubulin beta 2C chain 0.0321 0.7816 0.7802
Onchocerca volvulus 0.0061 0.1221 0.178
Echinococcus granulosus cpg binding protein 0.003 0.0433 0.0371
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0925 0.1184
Loa Loa (eye worm) hypothetical protein 0.0023 0.0245 0.0233
Giardia lamblia Delta tubulin 0.0071 0.1456 0.1735
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0245 0.0162
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1969 0.1917
Brugia malayi Pre-SET motif family protein 0.0031 0.0444 0.0568
Brugia malayi tubulin alpha chain - mouse 0.0215 0.5126 0.6558
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0145 0.3336 0.4178
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0245 0.0162
Loa Loa (eye worm) CHromoDomain protein family member 0.0024 0.0286 0.0286
Leishmania major alpha tubulin 0.0215 0.5126 0.6504
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0321 0.0261
Brugia malayi CXXC zinc finger family protein 0.0029 0.0391 0.0501
Echinococcus multilocularis hypothetical protein 0.0215 0.5126 0.5094
Plasmodium vivax SET domain protein, putative 0.0031 0.0444 0.042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.705 0.9005
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0245 0.0162
Schistosoma mansoni cpg binding protein 0.003 0.0433 0.0371
Plasmodium vivax glutathione reductase, putative 0.0052 0.0979 0.1115
Leishmania major beta tubulin 0.0321 0.7816 1
Leishmania major epsilon tubulin, putative 0.0163 0.3789 0.4766
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0245 0.0162
Echinococcus multilocularis tubulin alpha 3 chain 0.0215 0.5126 0.5094
Echinococcus multilocularis Tubulin alpha 1 chain 0.0215 0.5126 0.5094
Brugia malayi Cell division protein ftsZ 0.0071 0.1456 0.1863
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1425 0.1369
Echinococcus granulosus tubulin alpha chain 0.0215 0.5126 0.5094
Echinococcus granulosus tubulin alpha 1C chain 0.0215 0.5126 0.5094
Onchocerca volvulus 0.0029 0.0391 0.0267
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0245 0.0162
Trypanosoma brucei epsilon tubulin 0.0163 0.3789 0.4766
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0245 0.0182
Trichomonas vaginalis chromobox protein, putative 0.0084 0.18 0.2182
Trypanosoma brucei beta tubulin 0.0163 0.3789 0.4766
Plasmodium vivax tubulin epsilon chain, putative 0.0163 0.3789 0.4766
Brugia malayi Protein cec-1. 0.0023 0.0245 0.0314
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0245 0.0314
Brugia malayi CHD4 protein 0.0024 0.0286 0.0366
Giardia lamblia Gamma tubulin 0.0163 0.3789 0.4766
Brugia malayi TAR-binding protein 0.0069 0.1425 0.1823
Echinococcus granulosus peroxisome assembly protein 26 0.0215 0.5126 0.5094
Echinococcus multilocularis beta tubulin 0.0321 0.7816 0.7802
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0925 0.1111
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.705 0.9005
Loa Loa (eye worm) tubulin alpha chain 0.0215 0.5126 0.653
Echinococcus multilocularis tubulin alpha chain 0.0215 0.5126 0.5094
Loa Loa (eye worm) heterochromatin protein 1 0.014 0.3205 0.4051
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0053 0.1023 0.0965
Schistosoma mansoni alpha tubulin 0.0215 0.5126 0.5094
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.165 0.1987
Loa Loa (eye worm) tubulin beta chain 0.0321 0.7816 1
Giardia lamblia Beta tubulin 0.0321 0.7816 1
Schistosoma mansoni tubulin subunit epsilon 0.0163 0.3789 0.3748
Loa Loa (eye worm) tubulin gamma chain 0.0163 0.3789 0.4805
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.705 0.9005
Brugia malayi Tubulin alpha-2 chain 0.0215 0.5126 0.6558
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1425 0.1369
Plasmodium vivax tubulin alpha chain, putative 0.0215 0.5126 0.6504
Loa Loa (eye worm) RNA binding protein 0.0069 0.1425 0.1755
Plasmodium falciparum alpha tubulin 2 0.0215 0.5126 0.6504
Loa Loa (eye worm) hypothetical protein 0.0023 0.0245 0.0233
Leishmania major delta tubulin, putative 0.0071 0.1456 0.1735
Trichomonas vaginalis tubulin alpha chain, putative 0.0092 0.1999 0.244
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.705 0.9005
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0121 0.0057
Echinococcus multilocularis tubulin alpha chain 0.0215 0.5126 0.5094
Brugia malayi hypothetical protein 0.0023 0.0245 0.0314
Echinococcus multilocularis tubulin alpha chain 0.0215 0.5126 0.5094
Schistosoma mansoni tubulin subunit beta 0.0321 0.7816 0.7802
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0444 0.042
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.165 0.1987
Echinococcus granulosus tubulin alpha 3 chain 0.0215 0.5126 0.5094
Echinococcus multilocularis tar DNA binding protein 0.0069 0.1425 0.1369
Echinococcus granulosus Tubulin beta 2C chain 0.0321 0.7816 0.7802
Echinococcus granulosus tubulin alpha chain 0.0215 0.5126 0.5094
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0121 0.0057
Loa Loa (eye worm) hypothetical protein 0.0145 0.3336 0.4221
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0444 0.0382
Echinococcus granulosus chromobox protein 1 0.014 0.3205 0.3161
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0163 0.3789 0.4766
Leishmania major alpha tubulin 0.0215 0.5126 0.6504
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.1456 0.1735
Trichomonas vaginalis tubulin gamma chain, putative 0.0321 0.7816 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0121 0.0057
Trypanosoma brucei epsilon tubulin 0.0163 0.3789 0.4766
Echinococcus multilocularis Chromo domain 0.0023 0.0245 0.0182
Brugia malayi Tubulin beta chain 0.0092 0.1999 0.2557
Echinococcus multilocularis tubulin alpha 3 chain 0.0215 0.5126 0.5094
Echinococcus multilocularis Tubulin beta 2C chain 0.0321 0.7816 0.7802
Loa Loa (eye worm) hypothetical protein 0.0023 0.0245 0.0233
Loa Loa (eye worm) hypothetical protein 0.0023 0.0245 0.0233
Brugia malayi RNA binding protein 0.0069 0.1425 0.1823
Echinococcus multilocularis Tubulin beta 2C chain 0.0321 0.7816 0.7802
Trichomonas vaginalis tubulin, putative 0.0071 0.1456 0.1735
Schistosoma mansoni tubulin subunit alpha 0.0215 0.5126 0.5094
Loa Loa (eye worm) beta-tubulin 0.0321 0.7816 1
Loa Loa (eye worm) BEN-1 protein 0.0321 0.7816 1
Echinococcus granulosus tubulin subunit beta 0.0321 0.7816 0.7802
Trichomonas vaginalis tubulin alpha chain, putative 0.0163 0.3789 0.4766
Schistosoma mansoni alpha tubulin 0.0215 0.5126 0.5094
Brugia malayi Tubulin beta chain 0.0071 0.1456 0.1863
Leishmania major beta tubulin 0.0321 0.7816 1
Loa Loa (eye worm) tubulin alpha-2 chain 0.0215 0.5126 0.653
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0245 0.0182
Echinococcus granulosus tar DNA binding protein 0.0069 0.1425 0.1369
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0064 0.0082
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.1425 0.1755
Trichomonas vaginalis tubulin beta chain, putative 0.0215 0.5126 0.6504
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.3273 1
Leishmania major beta tubulin 0.0321 0.7816 1
Leishmania major beta tubulin 0.0321 0.7816 1
Brugia malayi Tubulin gamma chain 0.0163 0.3789 0.4847
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0925 0.1184
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0409 0.0375
Trichomonas vaginalis tubulin beta chain, putative 0.0092 0.1999 0.244
Loa Loa (eye worm) tubulin alpha chain 0.0215 0.5126 0.653
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0391 0.0422
Trypanosoma cruzi tubulin gamma chain 0.0163 0.3789 0.4766
Plasmodium vivax tubulin gamma chain, putative 0.0163 0.3789 0.4766
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1069 0.1232
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0245 0.0162
Trichomonas vaginalis set domain proteins, putative 0.0239 0.5729 0.7288
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1969 0.1917
Echinococcus granulosus beta tubulin 0.0321 0.7816 0.7802
Echinococcus granulosus Tubulin beta 2C chain 0.0321 0.7816 0.7802
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0131 0.2995 0.9116
Trypanosoma cruzi zeta tubulin, putative 0.0071 0.1456 0.1735
Echinococcus granulosus tubulin alpha 1C chain 0.0215 0.5126 0.5094
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0321 0.7816 0.7802
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.0245 0.0162
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0527 0.0674
Plasmodium falciparum tubulin gamma chain 0.0163 0.3789 0.4766
Loa Loa (eye worm) TAR-binding protein 0.0069 0.1425 0.1755
Schistosoma mansoni cpg binding protein 0.003 0.0433 0.0371
Trypanosoma brucei alpha tubulin 0.0215 0.5126 0.6504
Loa Loa (eye worm) tubulin beta-1 chain 0.0321 0.7816 1
Schistosoma mansoni tubulin subunit beta 0.0321 0.7816 0.7802
Loa Loa (eye worm) glutathione reductase 0.0052 0.0979 0.1179
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0286 0.0223
Mycobacterium tuberculosis Probable reductase 0.0118 0.266 0.8056
Schistosoma mansoni hypothetical protein 0.0023 0.0245 0.0182
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0071 0.1456 0.1735
Schistosoma mansoni hypothetical protein 0.0034 0.0527 0.0465
Trichomonas vaginalis hypothetical protein 0.0023 0.0245 0.0162
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0123 0.2793 0.3473
Echinococcus multilocularis tubulin epsilon chain 0.0163 0.3789 0.3748
Leishmania major alpha tubulin 0.0215 0.5126 0.6504
Brugia malayi Tubulin alpha chain 0.0215 0.5126 0.6558
Trichomonas vaginalis tubulin beta chain, putative 0.0215 0.5126 0.6504
Echinococcus multilocularis cpg binding protein 0.003 0.0433 0.0371
Loa Loa (eye worm) hypothetical protein 0.0023 0.0245 0.0233
Trypanosoma brucei zeta tubulin 0.0071 0.1456 0.1735
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0245 0.0314
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.0245 0.0162
Brugia malayi Thioredoxin reductase 0.0052 0.0979 0.1252
Loa Loa (eye worm) hypothetical protein 0.0123 0.2793 0.352
Leishmania major alpha tubulin 0.0215 0.5126 0.6504
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1969 0.1917
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0409 0.0375
Trypanosoma brucei beta tubulin 0.0321 0.7816 1
Echinococcus multilocularis tubulin delta chain 0.0071 0.1456 0.1401
Loa Loa (eye worm) hypothetical protein 0.0149 0.344 0.4355
Trichomonas vaginalis tubulin alpha chain, putative 0.0321 0.7816 1
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0245 0.0162
Echinococcus multilocularis tubulin gamma 1 chain 0.0163 0.3789 0.3748
Brugia malayi Heterochromatin protein 1 0.014 0.3205 0.41
Treponema pallidum fructose-bisphosphate aldolase 0.0291 0.705 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0245 0.0182
Entamoeba histolytica tubulin family protein 0.0321 0.7816 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0118 0.266 0.6628
Trichomonas vaginalis tubulin beta chain, putative 0.0321 0.7816 1
Echinococcus granulosus tubulin alpha chain 0.0215 0.5126 0.5094
Schistosoma mansoni cpg binding protein 0.0029 0.0391 0.0329
Echinococcus granulosus tubulin beta 4A class IVa 0.0321 0.7816 0.7802
Leishmania major alpha tubulin 0.0215 0.5126 0.6504
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0245 0.0162
Loa Loa (eye worm) tubulin alpha 2 0.0145 0.3336 0.4221
Plasmodium falciparum thioredoxin reductase 0.0052 0.0979 0.1115
Echinococcus granulosus chromobox protein 2 0.0023 0.0245 0.0182
Toxoplasma gondii alpha tubulin TUBA1 0.0215 0.5126 0.6504
Onchocerca volvulus 0.0053 0.1023 0.1419
Leishmania major beta tubulin 0.0321 0.7816 1
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.107 0.1234
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0444 0.0382
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.1456 0.1735
Brugia malayi Tubulin beta-1 chain 0.0321 0.7816 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0121 0.0154
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1233 0.1176
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0121 0.5
Echinococcus granulosus alpha tubulin 0.0215 0.5126 0.5094
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0245 0.0162
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.705 0.9005
Echinococcus granulosus chromobox protein 1 0.014 0.3205 0.3161
Toxoplasma gondii thioredoxin reductase 0.0052 0.0979 0.1115
Schistosoma mansoni tubulin subunit alpha 0.0215 0.5126 0.5094
Trypanosoma brucei tubulin delta chain 0.0071 0.1456 0.1735
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0333 0.0276
Leishmania major beta tubulin 0.0321 0.7816 1
Trichomonas vaginalis tubulin, putative 0.0092 0.1999 0.244
Leishmania major alpha tubulin 0.0215 0.5126 0.6504
Leishmania major beta tubulin 0.0321 0.7816 1
Echinococcus multilocularis peroxisome assembly protein 26 0.0215 0.5126 0.5094
Echinococcus multilocularis tubulin beta 1 chain 0.0321 0.7816 0.7802
Leishmania major alpha tubulin 0.0215 0.5126 0.6504
Trichomonas vaginalis tubulin epsilon chain, putative 0.0215 0.5126 0.6504
Schistosoma mansoni chromobox protein 0.014 0.3205 0.3161
Echinococcus multilocularis Tubulin beta 2C chain 0.0321 0.7816 0.7802
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1425 0.1369
Echinococcus granulosus Tubulin alpha 1 chain 0.0215 0.5126 0.5094
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0245 0.0162
Echinococcus multilocularis tubulin subunit beta 0.0321 0.7816 0.7802
Brugia malayi tubulin alpha-2 chain 0.0215 0.5126 0.6558
Trypanosoma brucei alpha tubulin 0.0215 0.5126 0.6504
Trichomonas vaginalis tubulin epsilon chain, putative 0.0071 0.1456 0.1735
Loa Loa (eye worm) tubulin alpha 2 0.0053 0.1003 0.1211
Treponema pallidum cell division protein FtsZ 0.0071 0.1456 0.1927
Plasmodium falciparum glutathione reductase 0.0052 0.0979 0.1115
Loa Loa (eye worm) tubulin alpha-3 chain 0.0123 0.2793 0.352
Leishmania major beta tubulin 0.0321 0.7816 1
Trichomonas vaginalis chromobox protein, putative 0.014 0.3205 0.4008
Entamoeba histolytica tubulin gamma chain 0.0163 0.3789 0.4681
Loa Loa (eye worm) BEN-1 protein 0.0321 0.7816 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0118 0.266 0.8056
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0979 0.2721
Leishmania major gamma-tubulin 0.0163 0.3789 0.4766
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0215 0.5126 0.6504
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0409 0.0375
Trichomonas vaginalis tubulin beta chain, putative 0.0215 0.5126 0.6504
Trypanosoma brucei zeta tubulin, putative 0.0071 0.1456 0.1735
Trichomonas vaginalis tubulin alpha chain, putative 0.0092 0.1999 0.244
Brugia malayi Tubulin alpha-2 chain 0.0215 0.5126 0.6558
Trichomonas vaginalis tubulin beta chain, putative 0.0215 0.5126 0.6504
Leishmania major beta tubulin 0.0321 0.7816 1
Echinococcus multilocularis tubulin alpha chain 0.0215 0.5126 0.5094
Giardia lamblia Beta tubulin 0.0321 0.7816 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0029 0.0409 0.0375
Brugia malayi Muscleblind-like protein 0.0149 0.344 0.4401
Trichomonas vaginalis tubulin epsilon chain, putative 0.0321 0.7816 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0321 0.7816 1
Trypanosoma cruzi tubulin delta chain 0.0071 0.1456 0.1735
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0245 0.0162
Echinococcus granulosus beta tubulin 0.0321 0.7816 0.7802
Brugia malayi chromobox protein homolog 3 0.0078 0.165 0.211
Onchocerca volvulus 0.0023 0.0245 0.000000058209
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.705 0.8989
Echinococcus multilocularis chromobox protein 2 0.0023 0.0245 0.0182
Echinococcus granulosus Tubulin beta 2C chain 0.0321 0.7816 0.7802
Leishmania major beta tubulin 0.0321 0.7816 1
Schistosoma mansoni alpha tubulin 0.0215 0.5126 0.5094
Brugia malayi glutathione reductase 0.0052 0.0979 0.1252
Echinococcus multilocularis tubulin subunit TubB 0.0215 0.5126 0.5094
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1969 0.1917
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0131 0.2995 0.9116
Echinococcus multilocularis muscleblind protein 0.0149 0.344 0.3397
Loa Loa (eye worm) alpha-tubulin 0.0215 0.5126 0.653
Brugia malayi Pre-SET motif family protein 0.021 0.4995 0.639
Trichomonas vaginalis tubulin, putative 0.0321 0.7816 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.1969 0.252
Echinococcus granulosus Tubulin alpha 1 chain 0.0215 0.5126 0.5094
Echinococcus granulosus tubulin beta 1 chain 0.0321 0.7816 0.7802
Onchocerca volvulus 0.0239 0.5729 1
Echinococcus granulosus muscleblind protein 0.0149 0.344 0.3397
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.705 0.8989
Leishmania major beta tubulin 0.0321 0.7816 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0071 0.1456 0.1735
Echinococcus multilocularis chromobox protein 1 0.014 0.3205 0.3161
Leishmania major beta tubulin 0.0321 0.7816 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0131 0.2995 0.8467
Loa Loa (eye worm) hypothetical protein 0.0061 0.1221 0.1492
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0029 0.0409 0.0375
Schistosoma mansoni tubulin subunit alpha 0.0215 0.5126 0.5094
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.4995 0.636
Giardia lamblia Epsilon tubulin 0.0071 0.1456 0.1735
Mycobacterium tuberculosis Probable dehydrogenase 0.0118 0.266 0.8056
Loa Loa (eye worm) hypothetical protein 0.0023 0.0245 0.0233
Trichomonas vaginalis tubulin beta chain, putative 0.0215 0.5126 0.6504
Echinococcus multilocularis tubulin alpha chain 0.0215 0.5126 0.5094
Leishmania major zeta tubulin, putative 0.0071 0.1456 0.1735
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0409 0.0375
Mycobacterium tuberculosis Cell division protein FtsZ 0.0071 0.1456 0.4235
Loa Loa (eye worm) hypothetical protein 0.0149 0.344 0.4355
Trypanosoma brucei beta tubulin 0.0321 0.7816 1
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0245 0.0314
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0245 0.0162
Echinococcus multilocularis Tubulin alpha 1 chain 0.0215 0.5126 0.5094
Leishmania major alpha tubulin 0.0215 0.5126 0.6504
Leishmania major alpha tubulin 0.0215 0.5126 0.6504
Echinococcus granulosus tubulin alpha 0.0163 0.3789 0.3748
Leishmania major beta tubulin 0.0321 0.7816 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0291 0.705 0.9005
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0245 0.0314
Giardia lamblia Beta tubulin 0.0321 0.7816 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0024 0.0286 0.0223
Trichomonas vaginalis chromobox protein, putative 0.014 0.3205 0.4008
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.1425 0.1823
Echinococcus multilocularis beta tubulin 0.0321 0.7816 0.7802
Trichomonas vaginalis tubulin gamma chain, putative 0.0163 0.3789 0.4766
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0979 0.092
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0118 0.266 0.8056
Echinococcus granulosus Chromo domain 0.0023 0.0245 0.0182
Echinococcus multilocularis tubulin alpha 1C chain 0.0215 0.5126 0.5094
Echinococcus granulosus tubulin epsilon chain 0.0163 0.3789 0.3748
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.3273 1
Leishmania major beta tubulin 0.0321 0.7816 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.705 0.9005
Echinococcus multilocularis dnaJ subfamily B 0.0407 1 1
Plasmodium falciparum tubulin delta chain, putative 0.0071 0.1456 0.1735
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0245 0.0182
Schistosoma mansoni hypothetical protein 0.0407 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0979 0.1115
Trypanosoma brucei trypanothione reductase 0.0052 0.0979 0.1115
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0064 0.0082
Leishmania major alpha tubulin 0.0215 0.5126 0.6504
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.1969 0.2458
Giardia lamblia Alpha-tubulin 0.0215 0.5126 0.6504
Trypanosoma cruzi alpha tubulin, putative 0.0215 0.5126 0.6504
Plasmodium falciparum heterochromatin protein 1 0.0023 0.0245 0.0162
Plasmodium vivax delta tubulin, putative 0.0071 0.1456 0.1735
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0245 0.0162
Loa Loa (eye worm) tubulin beta chain 0.0071 0.1456 0.1795
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0118 0.266 0.8056
Echinococcus multilocularis Tubulin alpha 1 chain 0.0215 0.5126 0.5094
Brugia malayi alpha-tubulin 0.0215 0.5126 0.6558
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0024 0.0286 0.0223
Echinococcus multilocularis chromobox protein 1 0.014 0.3205 0.3161
Schistosoma mansoni chromobox protein 0.014 0.3205 0.3161
Loa Loa (eye worm) hypothetical protein 0.0078 0.165 0.2045
Loa Loa (eye worm) hypothetical protein 0.0031 0.0444 0.0489
Trichomonas vaginalis tubulin epsilon chain, putative 0.0215 0.5126 0.6504
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0979 0.092
Loa Loa (eye worm) hypothetical protein 0.0215 0.5126 0.653
Echinococcus multilocularis tubulin alpha 1C chain 0.0215 0.5126 0.5094
Trypanosoma brucei beta tubulin 0.0321 0.7816 1
Schistosoma mansoni tubulin subunit beta 0.0321 0.7816 0.7802
Leishmania major beta tubulin 0.0321 0.7816 1
Leishmania major beta tubulin 0.0321 0.7816 1
Plasmodium vivax tubulin alpha chain, putative 0.0215 0.5126 0.6504
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0245 0.0162
Loa Loa (eye worm) helicase 0.0023 0.0245 0.0233
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1969 0.1917
Trypanosoma brucei tubulin gamma chain 0.0163 0.3789 0.4766
Entamoeba histolytica tubulin alpha chain, putative 0.0215 0.5126 0.6447
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.04 0.0338
Loa Loa (eye worm) tubulin beta-4 chain 0.0321 0.7816 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0245 0.0162
Trichomonas vaginalis tubulin gamma chain, putative 0.0163 0.3789 0.4766
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0145 0.3336 0.4221
Schistosoma mansoni tubulin subunit beta 0.0071 0.1456 0.1401
Leishmania major alpha tubulin 0.0215 0.5126 0.6504
Leishmania major alpha tubulin 0.0215 0.5126 0.6504
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0444 0.0382
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0084 0.18 0.2836
Loa Loa (eye worm) tubulin alpha 2 0.0145 0.3336 0.4221
Echinococcus granulosus tubulin delta chain 0.0071 0.1456 0.1401
Mycobacterium ulcerans cell division protein FtsZ 0.0071 0.1456 0.4235
Echinococcus granulosus tubulin gamma 1 chain 0.0163 0.3789 0.3748
Schistosoma mansoni tubulin subunit beta 0.0321 0.7816 0.7802
Loa Loa (eye worm) hypothetical protein 0.0034 0.0527 0.0597
Leishmania major beta tubulin 0.0321 0.7816 1
Trichomonas vaginalis tubulin, putative 0.0092 0.1999 0.244
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0071 0.1456 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0118 0.266 0.8056
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0444 0.0382
Trypanosoma brucei alpha tubulin 0.0215 0.5126 0.6504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.705 0.9005
Mycobacterium tuberculosis Probable oxidoreductase 0.0131 0.2995 0.9116
Loa Loa (eye worm) alpha-tubulin 0.0215 0.5126 0.653
Echinococcus granulosus Chromobox protein 3 0.0023 0.0245 0.0182
Trypanosoma cruzi zeta tubulin, putative 0.0071 0.1456 0.1735
Toxoplasma gondii alpha-tubulin I, putative 0.0215 0.5126 0.6504
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.0245 0.0162
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.3273 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0444 0.0382
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0071 0.1456 0.1735
Leishmania major beta tubulin 0.0321 0.7816 1
Echinococcus multilocularis muscleblind protein 1 0.0149 0.344 0.3397
Echinococcus granulosus tubulin alpha 3 chain 0.0215 0.5126 0.5094
Entamoeba histolytica tubulin family protein 0.0321 0.7816 1
Toxoplasma gondii beta tubulin 0.0321 0.7816 1
Entamoeba histolytica tubulin alpha-1 chain 0.0215 0.5126 0.6447
Plasmodium falciparum tubulin beta chain 0.0321 0.7816 1
Loa Loa (eye worm) tubulin beta-2A chain 0.0321 0.7816 1
Trypanosoma brucei beta tubulin 0.0321 0.7816 1
Plasmodium vivax tubulin beta chain, putative 0.0321 0.7816 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1969 0.1917
Trypanosoma cruzi epsilon tubulin, putative 0.0163 0.3789 0.4766
Echinococcus granulosus tubulin alpha chain 0.0215 0.5126 0.5094
Schistosoma mansoni tubulin subunit gamma 0.0163 0.3789 0.3748

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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