Detailed information for compound 1590623

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 238.634 | Formula: C8H7ClN6O
  • H donors: 2 H acceptors: 4 LogP: 1.22 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)/C=N/n1nnnc1N)O
  • InChi: 1S/C8H7ClN6O/c9-6-1-2-7(16)5(3-6)4-11-15-8(10)12-13-14-15/h1-4,16H,(H2,10,12,14)/b11-4+
  • InChiKey: WCGJNCYZQXYLMQ-NYYWCZLTSA-N  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutaminase Starlite/ChEMBL No references
Caenorhabditis elegans Protein GLD-1 Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi tumor suppressor. Get druggable targets OG5_170288 All targets in OG5_170288
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) tumor suppressor Get druggable targets OG5_170288 All targets in OG5_170288
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0104 0.0183
Loa Loa (eye worm) hypothetical protein 0.0034 0.0352 0.0768
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0032 0.0074
Schistosoma mansoni hypothetical protein 0.0372 0.436 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0288 0.0285
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0069 0.0158
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0069 0.0145
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0104 0.0183
Echinococcus multilocularis importin 5 0.0007 0.0022 0.0019
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0046 0.0491 1
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0069 0.0066
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0229 0.532
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0229 0.6165
Onchocerca volvulus 0.0026 0.025 0.0943
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0051 0.0106
Schistosoma mansoni glutaminase 0.033 0.3865 0.8866
Schistosoma mansoni importin-beta 2 0.0007 0.0022 0.005
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0104 0.1536
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0145
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0248 0.0539
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0432 0.0991
Brugia malayi Temporarily assigned gene name protein 44 0.0033 0.0334 0.0727
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0357 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0104 0.0237
Schistosoma mansoni ferritin 0.0008 0.0034 0.0078
Schistosoma mansoni nuclear receptor 0.0005 0.0003 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0069 0.0145
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0248 0.0245
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0104 0.1758
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0104 0.0237
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0491 0.1072
Schistosoma mansoni ferritin light chain 0.0008 0.0034 0.0078
Echinococcus multilocularis protein quaking 0.0033 0.0334 0.0331
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0104 0.1758
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0279 0.069
Loa Loa (eye worm) importin-beta domain-containing protein 0.0007 0.0022 0.0042
Brugia malayi hypothetical protein 0.0024 0.0229 0.0496
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0033 0.0338 0.0844
Echinococcus multilocularis geminin 0.0152 0.1753 0.1751
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0279 0.069
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0046 0.0491 0.1192
Loa Loa (eye worm) hypothetical protein 0.0034 0.0352 0.0768
Brugia malayi hypothetical protein 0.0033 0.0334 0.0727
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0071 0.0158
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0288 0.0654
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0014 0.0104 0.1536
Brugia malayi hypothetical protein 0.0006 0.001 0.0016
Plasmodium vivax acyl-CoA synthetase, putative 0.0034 0.0352 0.9857
Loa Loa (eye worm) hypothetical protein 0.0034 0.0352 0.0768
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0069 0.0145
Onchocerca volvulus 0.0046 0.0491 0.1859
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0016
Loa Loa (eye worm) glutaminase 2 0.033 0.3865 0.8481
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0432 0.0985
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0069 0.0145
Leishmania major importin beta-1 subunit, putative 0.0028 0.0279 0.5484
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0069 0.0145
Loa Loa (eye worm) CXXC zinc finger family protein 0.0026 0.025 0.0544
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0033 0.0338 0.0793
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0104 0.1536
Onchocerca volvulus 0.0029 0.0288 0.1086
Echinococcus multilocularis expressed protein 0.0008 0.0034 0.0031
Brugia malayi nuclear receptor NHR-88 0.0011 0.0069 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0069 0.0145
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0432 0.0985
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0288 0.066
Loa Loa (eye worm) hypothetical protein 0.0014 0.0104 0.0223
Schistosoma mansoni ferritin 0.0008 0.0034 0.0078
Onchocerca volvulus 0.0011 0.0069 0.0252
Echinococcus granulosus protein quaking 0.0033 0.0334 0.076
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0033 0.0338 0.6137
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.0491 0.1192
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0069 0.0152
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0069 0.0066
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0069 0.0152
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0069 0.0158
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0069 0.0066
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0069 0.0158
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0104 0.1536
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0229 0.6165
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0069 0.0152
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0104 0.0183
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.033 0.6482
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0069 0.0158
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0069 0.0158
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0104 0.2457
Echinococcus multilocularis translational activator gcn1 0.0007 0.0022 0.0019
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0229 0.4013
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0104 0.1536
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0069 0.0066
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0016
Loa Loa (eye worm) oxidoreductase 0.0014 0.0104 0.0223
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0338 1
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0069 0.0145
Schistosoma mansoni apoferritin-2 0.0008 0.0034 0.0078
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0288 0.5163
Entamoeba histolytica hypothetical protein 0.0028 0.0279 0.5484
Treponema pallidum bacterioferrin (TpF1) 0.0008 0.0034 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0069 0.0066
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0104 0.0183
Loa Loa (eye worm) hypothetical protein 0.0024 0.0229 0.0496
Trichomonas vaginalis set domain proteins, putative 0.0226 0.2629 0.679
Loa Loa (eye worm) hypothetical protein 0.0034 0.0352 0.0768
Plasmodium falciparum importin beta, putative 0.0035 0.0357 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0248 0.0539
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0248 0.6151
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0034 0.0352 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0069 0.0158
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0069 0.0152
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0491 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.005 0.0537 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0069 0.0145
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0069 0.0152
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0069 0.0158
Schistosoma mansoni ferritin 0.0008 0.0034 0.0078
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0491 0.1192
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0491 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0248 0.6744
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0145
Leishmania major GTP-binding protein, putative 0.0026 0.0248 0.4824
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0491 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0432 0.0429
Schistosoma mansoni ran 0.0026 0.0248 0.0569
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0033 0.0338 0.0844
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0104 0.0183
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0229 0.6165
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0104 0.0223
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0104 0.0223
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0357 0.651
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0003 0.0006
Loa Loa (eye worm) kap beta 3 protein 0.0007 0.0022 0.0042
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0069 0.0152
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0071 0.0069
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0104 0.16
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0248 0.4391
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.001 0.0016
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0104 0.0223
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0069 0.0145
Echinococcus granulosus snurportin 1 0.0372 0.436 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.436 0.9566
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0104 0.0223
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0279 0.069
Brugia malayi glutaminase DH11.1 0.033 0.3865 0.8481
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0016
Echinococcus granulosus cpg binding protein 0.0027 0.0268 0.0608
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0032 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0432 0.0991
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0288 0.0285
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0032 0.0068
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0005 0.0003 0.0006
Entamoeba histolytica Ran family GTPase 0.0026 0.0248 0.4824
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0069 0.0145
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0491 0.1072
Schistosoma mansoni importin beta-1 0.0035 0.0357 0.0819
Schistosoma mansoni hypothetical protein 0.0152 0.1753 0.4021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.033 0.6482
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.003 0.0297 0.575
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0069 0.0252
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0104 0.1536
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0104 0.1536
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0104 0.1758
Brugia malayi CXXC zinc finger family protein 0.0026 0.025 0.0544
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0056 0.0607 0.1391
Brugia malayi nuclear hormone receptor 0.0011 0.0069 0.0145
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0432 0.0429
Schistosoma mansoni nuclear receptor 0.0005 0.0003 0.0006
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0338 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0199 0.2304 0.5052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0069 0.0152
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0491 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.001 0.0016
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0051 0.0048
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.005 0.0103
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0229 0.532
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0104 0.1536
Schistosoma mansoni nuclear receptor nhr-48 0.0005 0.0003 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0069 0.0145
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.001 0.0016
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.001 0.0007
Echinococcus multilocularis ferritin 0.0008 0.0034 0.0031
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0104 0.0239
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0069 0.0152
Schistosoma mansoni hypothetical protein 0.0033 0.0334 0.0766
Brugia malayi hypothetical protein 0.0006 0.001 0.0016
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0104 0.16
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0104 0.0183
Schistosoma mansoni ferritin 0.0008 0.0034 0.0078
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0338 0.9427
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0069 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0069 0.0145
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0432 0.0991
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.001 0.0016
Brugia malayi ecdysteroid receptor 0.0011 0.0069 0.0145
Entamoeba histolytica acyl-coA synthetase, putative 0.0046 0.0491 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.001 0.0022
Echinococcus multilocularis snurportin 1 0.0372 0.436 0.4358
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0104 0.2457
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0014 0.0104 0.1536
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0069 0.0152
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0145
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0491 1
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0491 0.1072
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0145
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0491 1
Trichomonas vaginalis glutaminase, putative 0.033 0.3865 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0032 0.0068
Echinococcus granulosus importin 5 0.0007 0.0022 0.0044
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0046 0.0491 0.1192
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0104 0.2457
Plasmodium vivax importin-beta 2, putative 0.0035 0.0357 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0279 0.7476
Schistosoma mansoni cpg binding protein 0.0026 0.025 0.0574
Loa Loa (eye worm) hypothetical protein 0.0033 0.0334 0.0727
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.003 0.0297 0.575
Loa Loa (eye worm) inositol-1 0.0033 0.0338 0.0736
Echinococcus granulosus importin subunit beta 1 0.0035 0.0357 0.0814
Echinococcus granulosus translational activator gcn1 0.0007 0.0022 0.0044
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0104 0.0183
Schistosoma mansoni hypothetical protein 0.0033 0.0334 0.0766
Loa Loa (eye worm) hypothetical protein 0.0046 0.0491 0.1072
Brugia malayi tumor suppressor. 0.0388 0.4557 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0352 0.0768
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0104 0.0183
Onchocerca volvulus 0.0014 0.0104 0.0387
Brugia malayi Importin beta-1 subunit 0.0035 0.0357 0.0778
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0069 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0069 0.0145
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0069 0.0158
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0104 0.0183
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0069 0.0252
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0104 0.0183
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0104 0.0223
Brugia malayi nuclear receptor RXR 0.0006 0.001 0.0016
Loa Loa (eye worm) glutaminase 0.033 0.3865 0.8481
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0069 0.0145
Schistosoma mansoni coup transcription factor 0.0011 0.0069 0.0158
Echinococcus granulosus inositol monophosphatase 1 0.0033 0.0338 0.077
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0012 0.0082 0.1047
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.001 0.0022
Echinococcus granulosus dnaJ subfamily B 0.0368 0.4312 0.989
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0032 0.0029
Echinococcus multilocularis inositol monophosphatase 1 0.0033 0.0338 0.0335
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.0491 0.1192
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0069 0.0145
Mycobacterium ulcerans glutaminase 0.033 0.3865 1
Echinococcus granulosus expressed protein 0.0008 0.0034 0.0072
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0248 0.6151
Schistosoma mansoni hypothetical protein 0.0011 0.0071 0.0164
Onchocerca volvulus 0.0014 0.0104 0.0387
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0041 0.0432 0.0943
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0041 0.0432 0.0943
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0288 0.066
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0033 0.0338 0.6742
Brugia malayi Pre-SET motif family protein 0.0199 0.2304 0.5052
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0016
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0229 0.6165
Schistosoma mansoni ferritin light chain 0.0008 0.0034 0.0078
Brugia malayi steroid hormone receptor 0.0011 0.0069 0.0145
Loa Loa (eye worm) hypothetical protein 0.0035 0.0357 0.0778
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.033 0.6482
Schistosoma mansoni cpg binding protein 0.0027 0.0268 0.0614
Plasmodium vivax SET domain protein, putative 0.0029 0.0288 0.793
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0288 0.066
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0104 0.1536
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0069 0.0158
Brugia malayi hypothetical protein 0.0015 0.0128 0.0274
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0069 0.0158
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0005 0.0003 0.0006
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0104 0.0183
Echinococcus granulosus transportin 1 0.0007 0.0022 0.0044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0145
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0069 0.0066
Onchocerca volvulus 0.0014 0.0104 0.0387
Schistosoma mansoni inositol monophosphatase 0.0033 0.0338 0.0775
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0051 0.0111
Trichomonas vaginalis ran, putative 0.0026 0.0248 0.061
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0357 0.0355
Schistosoma mansoni zinc finger protein 0.0005 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0014 0.0104 0.0223
Echinococcus granulosus geminin 0.0152 0.1753 0.4018
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0104 0.2457
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0069 0.0066
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0104 0.0183
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0357 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0248 0.6744
Loa Loa (eye worm) hypothetical protein 0.0046 0.0491 0.1072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0069 0.0145
Plasmodium falciparum acyl-CoA synthetase 0.0034 0.0352 0.9857
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0034 0.0352 0.0831
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0104 0.1536
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0104 0.0183
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0033 0.0338 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0104 0.0183
Schistosoma mansoni inositol monophosphatase 0.0033 0.0338 0.0775
Onchocerca volvulus 0.0226 0.2629 1
Schistosoma mansoni hypothetical protein 0.0368 0.4312 0.989
Trichomonas vaginalis inositol monophosphatase, putative 0.0033 0.0338 0.0844
Schistosoma mansoni hypothetical protein 0.0152 0.1753 0.4021
Brugia malayi Inositol-1 0.0033 0.0338 0.0736
Loa Loa (eye worm) hypothetical protein 0.0046 0.0491 0.1072
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0248 0.6744
Trichomonas vaginalis hypothetical protein 0.0007 0.0022 0.0023
Onchocerca volvulus 0.0014 0.0104 0.0387
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0288 0.066
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0104 0.0102
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0104 0.1758
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0491 0.1192
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0069 0.0145
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0145
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0104 0.1536
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0069 0.0145
Brugia malayi kap beta 3 protein 0.0007 0.0022 0.0042
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0003 0.0006
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0491 0.1192
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0104 0.0233
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.0491 1
Leishmania major hypothetical protein, conserved 0.0024 0.0229 0.4409
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0014 0.0104 0.1536
Loa Loa (eye worm) tumor suppressor 0.0388 0.4557 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0034 0.0352 0.6971
Loa Loa (eye worm) hypothetical protein 0.0029 0.0288 0.0626
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0104 0.0183
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0104 0.1536
Schistosoma mansoni cpg binding protein 0.0027 0.0268 0.0614
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0069 0.0145
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0248 0.0563
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0248 0.5
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0104 0.0223
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0069 0.0066
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0104 0.0183
Echinococcus granulosus ferritin 0.0008 0.0034 0.0072
Brugia malayi Pre-SET motif family protein 0.0029 0.0288 0.0626
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0145
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0069 0.0066
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.033 0.6482
Echinococcus multilocularis cpg binding protein 0.0027 0.0268 0.0265
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0069 0.0158
Brugia malayi RNA, U transporter 1 0.0099 0.112 0.2453
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0069 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0069 0.0145
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0104 0.0223
Trichomonas vaginalis ferritin, putative 0.0008 0.0034 0.0055
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0104 0.0183
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0338 0.6742
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0069 0.0145
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0269 0.0611
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0104 0.16
Loa Loa (eye worm) hypothetical protein 0.0006 0.001 0.0016
Schistosoma mansoni ran 0.0026 0.0248 0.0569
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0491 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0145
Schistosoma mansoni apoferritin-2 0.0008 0.0034 0.0078
Echinococcus multilocularis dnaJ subfamily B 0.0368 0.4312 0.431
Mycobacterium ulcerans hypothetical protein 0.0046 0.0491 0.1192
Echinococcus multilocularis transportin 1 0.0007 0.0022 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0104 0.0223
Echinococcus granulosus hypothetical protein 0.0033 0.0334 0.076
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0069 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0069 0.0145

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.196 uM PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of GLD-1 protein - TGE RNA interaction. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2280, AID2290, AID2459] ChEMBL. No reference
IC50 (functional) = 35.1 uM PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay using Cy5 labeled peptide. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 38.81 uM PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) > 75.326 um PUBCHEM_BIOASSAY: Counterscreen for inhibitors of gld-1: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of the HIV Rev protein-RRE RNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2290 (Summary (gld-1 inhibitors)), 2280 (Primary screen (gld-1 inhibitors in singlicate))] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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