TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 536.747 | Formula: C36H44N2O2
H donors: 2 H acceptors: 2 LogP: 7.86 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: Oc1cccc(c1)C12C[C@H](CC(C1)N(CC2C)CCCc1ccccc1)NC(=O)C1(CCCC1)c1ccccc1
InChi: 1S/C36H44N2O2/c1-27-26-38(21-11-14-28-12-4-2-5-13-28)32-23-31(24-36(27,25-32)30-17-10-18-33(39)22-30)37-34(40)35(19-8-9-20-35)29-15-6-3-7-16-29/h2-7,10,12-13,15-18,22,27,31-32,39H,8-9,11,14,19-21,23-26H2,1H3,(H,37,40)/t27?,31-,32?,36?/m0/s1
InChiKey: NZPBORMKRQQWNV-UOTZXRTJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	opioid receptor, delta 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	tm gpcr rhodopsin	Get druggable targets OG5_139759	All targets in OG5_139759
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Get druggable targets OG5_139759	All targets in OG5_139759

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	hypothetical protein	0.0808	0.0822	0.1111
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0808	0.0822	0.0822
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0808	0.0822	0.0822
Trypanosoma brucei	lanosterol synthase	0.0378	0.0374	0.1451
Toxoplasma gondii	hypothetical protein	0.7115	0.7402	1
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.1394	0.1434	0.142
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0041	0.0041
Onchocerca volvulus		0.0808	0.0822	0.1593
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.002	0	0.5
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0059	0.0041	0.0041
Echinococcus multilocularis	neuropeptide receptor	0.0059	0.0041	0.0041
Schistosoma mansoni	neuropeptide receptor	0.0059	0.0041	0.0041
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0108	0.0093	0.0093
Echinococcus multilocularis	neuropeptide Y receptor	0.0059	0.0041	0.0041
Echinococcus granulosus	tm gpcr rhodopsin	0.0684	0.0693	0.0693
Schistosoma mansoni	amine GPCR	0.0059	0.0041	0.0041
Brugia malayi	Serotonin receptor	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Brugia malayi	AKH receptor	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0059	0.0041	0.0041
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0046	0.0046
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.002	0	0.5
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.002	0	0.5
Leishmania major	farnesyltransferase beta subunit	0.1394	0.1434	0.5563
Schistosoma mansoni	amine GPCR	0.0059	0.0041	0.0041
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0015	0.0015
Echinococcus multilocularis	serotonin receptor	0.0789	0.0803	0.0803
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0808	0.0822	0.0822
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.249	0.2577	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0127	0.0127
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0015	0.0015
Brugia malayi	latrophilin 2 splice variant baaae	0.0074	0.0057	0.0057
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.002	0	0.5
Echinococcus granulosus	sex peptide receptor	0.0059	0.0041	0.0041
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0015	0.0015
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.1394	0.1434	0.5563
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0059	0.0041	0.0041
Brugia malayi	hypothetical protein	0.0024	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0808	0.0822	0.0822
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.002	0	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0059	0.0041	0.0041
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.002	0	0.5
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.1394	0.1434	0.143
Schistosoma mansoni	hypothetical protein	0.0074	0.0057	0.0057
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0059	0.0041	0.0041
Schistosoma mansoni	opsin-like receptor	0.0059	0.0041	0.0041
Echinococcus granulosus	g-protein coupled receptor	0.0059	0.0041	0.0041
Echinococcus granulosus	neuropeptide receptor A26	0.0059	0.0041	0.0041
Schistosoma mansoni	amine GPCR	0.0059	0.0041	0.0041
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0378	0.0374	0.0374
Loa Loa (eye worm)	neuropeptide F receptor	0.0059	0.0041	0.0041
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.002	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0041	0.0041
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0059	0.0041	0.0041
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0005	0.0019
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0015	0.0015
Toxoplasma gondii	Rab geranylgeranyl transferase type II beta subunit, putative	0.0378	0.0374	0.0505
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.9605	1	1
Brugia malayi	RNA binding protein	0.0064	0.0046	0.0046
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.249	0.2577	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Echinococcus granulosus	neuropeptides capa receptor	0.0059	0.0041	0.0041
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0808	0.0822	0.0822
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.7115	0.7402	0.7398
Onchocerca volvulus		0.249	0.2577	0.5174
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0059	0.0041	0.0041
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0041	0.0041
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.249	0.2577	0.2577
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.249	0.2577	1
Trypanosoma cruzi	protein farnesyltransferase, putative	0.1394	0.1434	0.5563
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0059	0.0041	0.0041
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0808	0.0822	0.0822
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0808	0.0822	0.0822
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0015	0.0015
Echinococcus granulosus	neuropeptide Y receptor	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Echinococcus granulosus	GPCR family 2	0.0034	0.0015	0.0015
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.1394	0.1434	0.142
Echinococcus multilocularis	sex peptide receptor	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Giardia lamblia	Prenyltransferase	0.1394	0.1434	0.1101
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Schistosoma mansoni	hypothetical protein	0.0059	0.0041	0.0041
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0046	0.0046
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0005	0.0007
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0059	0.0041	0.0041
Echinococcus granulosus	neuropeptides capa receptor	0.0059	0.0041	0.0041
Echinococcus multilocularis	neuropeptide receptor	0.0059	0.0041	0.0041
Leishmania major	geranylgeranyltransferase, putative	0.0378	0.0374	0.1451
Schistosoma mansoni	neuropeptide receptor	0.0059	0.0041	0.0041
Echinococcus granulosus	biogenic amine 5HT receptor	0.0059	0.0041	0.0041
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0041	0.0041
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.9605	1	1
Giardia lamblia	Rab geranylgeranyltransferase	0.9605	1	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0059	0.0041	0.0041
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0041	0.0041
Brugia malayi	larval opioid receptor	0.0059	0.0041	0.0041
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0059	0.0041	0.0041
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.9605	1	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0808	0.0822	0.0822
Schistosoma mansoni	sodium/chloride dependent transporter	0.4758	0.4944	0.4944
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0059	0.0041	0.0041
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.249	0.2577	0.2574
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0005	0.0005
Toxoplasma gondii	hypothetical protein	0.0808	0.0822	0.1111
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Schistosoma mansoni	neuropeptide f receptor 76f	0.0059	0.0041	0.0041
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0059	0.0041	0.0041
Loa Loa (eye worm)	neuropeptide F receptor	0.0059	0.0041	0.0041
Onchocerca volvulus	Huntingtin homolog	0.0141	0.0127	0.0174
Echinococcus multilocularis	allatostatin A receptor	0.0059	0.0041	0.0041
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0808	0.0822	0.0822
Echinococcus granulosus	allatostatin A receptor	0.0059	0.0041	0.0041
Echinococcus multilocularis	g protein coupled receptor	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0789	0.0803	0.0803
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0378	0.0374	0.0374
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0808	0.0822	0.0822
Trypanosoma cruzi	lanosterol synthase, putative	0.0378	0.0374	0.1451
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.1394	0.1434	0.1434
Loa Loa (eye worm)	solute carrier family 6 member 4	0.4758	0.4944	0.4944
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0057	0.0057
Leishmania major	hypothetical protein, conserved	0.0024	0.0005	0.0019
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.9605	1	1
Brugia malayi	ORL1-like opioid receptor	0.0059	0.0041	0.0041
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.9605	1	1
Brugia malayi	hypothetical protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0059	0.0041	0.0041
Schistosoma mansoni	hypothetical protein	0.0059	0.0041	0.0041
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0046	0.0046
Schistosoma mansoni	hypothetical protein	0.0034	0.0015	0.0015
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0046	0.0046
Schistosoma mansoni	growth hormone secretagogue receptor	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0059	0.0041	0.0041
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0037	0.0018	0.0018
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.1394	0.1434	0.1101
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0378	0.0374	0.0359
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.002	0	0.5
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.249	0.2577	1
Brugia malayi	hypothetical protein	0.0059	0.0041	0.0041
Brugia malayi	G protein-coupled receptor	0.0059	0.0041	0.0041
Plasmodium vivax	geranylgeranyl transferase type2 beta subunit, putative	0.0378	0.0374	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0808	0.0822	0.1111
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0059	0.0041	0.0041
Echinococcus multilocularis	neuropeptides capa receptor	0.0059	0.0041	0.0041
Brugia malayi	Dopamine receptor protein 2	0.0059	0.0041	0.0041
Schistosoma mansoni	opsin-like receptor	0.0059	0.0041	0.0041
Plasmodium vivax	geranylgeranyltransferase, putative	0.0378	0.0374	0.0369
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.4758	0.4944	0.4944
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0059	0.0041	0.0041
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.002	0	0.5
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0059	0.0041	0.0041
Schistosoma mansoni	hypothetical protein	0.0034	0.0015	0.0015
Echinococcus granulosus	dro:myosuppressin receptor	0.0059	0.0041	0.0041
Echinococcus granulosus	g protein coupled receptor	0.0059	0.0041	0.0041
Brugia malayi	neuropeptide F receptor	0.0059	0.0041	0.0041
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0059	0.0041	0.0041
Echinococcus granulosus	tm gpcr rhodopsin	0.0059	0.0041	0.0041
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0808	0.0822	0.0822
Brugia malayi	Probable protein farnesyltransferase beta subunit, putative	0.0378	0.0374	0.0374
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0041	0.0041
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Echinococcus granulosus	orexin receptor type 2	0.0059	0.0041	0.0041
Echinococcus granulosus	7TM GPCR rhodopsin	0.0059	0.0041	0.0041
Trypanosoma brucei	hypothetical protein, conserved	0.249	0.2577	1
Schistosoma mansoni	voltage-gated potassium channel	0.0041	0.0022	0.0022
Loa Loa (eye worm)	MH2 domain-containing protein	0.0137	0.0123	0.0123
Loa Loa (eye worm)	melatonin receptor type 1A	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0059	0.0041	0.0041
Schistosoma mansoni	voltage-gated potassium channel	0.0041	0.0022	0.0022
Plasmodium vivax	hypothetical protein, conserved	0.0808	0.0822	0.0818
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0808	0.0822	0.0822
Brugia malayi	hypothetical protein	0.0059	0.0041	0.0041
Trypanosoma cruzi	hypothetical protein, conserved	0.249	0.2577	1
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.9605	1	1
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0808	0.0822	0.0822
Brugia malayi	hypothetical protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.249	0.2577	1
Echinococcus granulosus	g protein coupled receptor	0.0059	0.0041	0.0041
Onchocerca volvulus		0.0808	0.0822	0.1593
Brugia malayi	follicle stimulating hormone receptor	0.0059	0.0041	0.0041
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.0041	0.0041
Echinococcus multilocularis	neuropeptide s receptor	0.0059	0.0041	0.0041
Schistosoma mansoni	amine GPCR	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0127	0.0127
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.249	0.2577	1
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.9605	1	1
Loa Loa (eye worm)	hypothetical protein	0.4758	0.4944	0.4944
Schistosoma mansoni	neuropeptide F-like receptor	0.0059	0.0041	0.0041
Schistosoma mansoni	hypothetical protein	0.0059	0.0041	0.0041
Mycobacterium leprae	Conserved hypothetical protein	0.002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0808	0.0822	0.0822
Loa Loa (eye worm)	G-protein coupled receptor	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0059	0.0041	0.0041
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0041	0.0041
Loa Loa (eye worm)	norepinephrine transporter	0.4758	0.4944	0.4944
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0808	0.0822	0.0822
Schistosoma mansoni	hypothetical protein	0.0059	0.0041	0.0041
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0808	0.0822	0.0822
Schistosoma mansoni	adenoreceptor	0.0059	0.0041	0.0041
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0059	0.0041	0.0041
Brugia malayi	Dopamine receptor protein 1	0.0059	0.0041	0.0041
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0059	0.0041	0.0041
Onchocerca volvulus		0.4758	0.4944	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Brugia malayi	GnHR receptor homolog	0.0059	0.0041	0.0041
Schistosoma mansoni	neuropeptide receptor	0.0059	0.0041	0.0041
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0059	0.0041	0.0041
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.002	0	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0059	0.0041	0.0041
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0046	0.0046
Brugia malayi	Dopamine receptor	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Echinococcus multilocularis	neuropeptide receptor A26	0.0059	0.0041	0.0041
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.249	0.2577	0.2289
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.1394	0.1434	0.142
Brugia malayi	hypothetical protein	0.0808	0.0822	0.0822
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0059	0.0041	0.0041
Schistosoma mansoni	neuropeptide receptor	0.0059	0.0041	0.0041
Echinococcus granulosus	sodium and chloride dependent glycine	0.0808	0.0822	0.0822
Echinococcus granulosus	tm gpcr rhodopsin	0.0059	0.0041	0.0041
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0037	0.0018	0.0018
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.9605	1	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0059	0.0041	0.0041
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.002	0	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0789	0.0803	0.0803
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.0041	0.0041
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.1394	0.1434	0.1434
Schistosoma mansoni	histamine h1 receptor	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Schistosoma mansoni	geranylgeranyl transferase type II beta subunit	0.0378	0.0374	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0059	0.0041	0.0041
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0046	0.0046
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0059	0.0041	0.0041
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.1394	0.1434	0.142
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0808	0.0822	0.0822
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.002	0	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0059	0.0041	0.0041
Echinococcus multilocularis	somatostatin receptor	0.0059	0.0041	0.0041
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.0041	0.0041
Treponema pallidum	sodium- and chloride- dependent transporter	0.4758	0.4944	0.5
Plasmodium falciparum	amino acid transporter, putative	0.0808	0.0822	0.0818
Trypanosoma cruzi	hypothetical protein, conserved	0.0378	0.0374	0.1451
Schistosoma mansoni	biogenic amine receptor	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	0.0378	0.0374	0.0374
Brugia malayi	putative neuropeptide receptor NPR1	0.0059	0.0041	0.0041
Brugia malayi	RE15519p	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0808	0.0822	0.0822
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.1394	0.1434	0.142
Trypanosoma cruzi	lanosterol synthase, putative	0.0378	0.0374	0.1451
Trypanosoma cruzi	hypothetical protein, conserved	0.249	0.2577	1
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.249	0.2577	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0005	0.0019
Echinococcus multilocularis	neuropeptide Y receptor	0.0059	0.0041	0.0041
Brugia malayi	MH2 domain containing protein	0.0137	0.0123	0.0123
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0684	0.0693	0.0693
Trypanosoma cruzi	geranylgeranyl transferase type II beta subunit, putative	0.0378	0.0374	0.1451
Brugia malayi	hypothetical protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0808	0.0822	0.0822
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.249	0.2577	0.2574
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0059	0.0041	0.0041
Echinococcus granulosus	hypothetical protein	0.0059	0.0041	0.0041
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.1394	0.1434	0.1434
Echinococcus multilocularis	fmrfamide receptor	0.0059	0.0041	0.0041
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.9605	1	1
Brugia malayi	hypothetical protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0037	0.0018	0.0018
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0041	0.0041
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.002	0	0.5
Mycobacterium leprae	putative cytochrome p450	0.002	0	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.4758	0.4944	0.4944
Brugia malayi	Serotonin receptor	0.0059	0.0041	0.0041
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0041	0.0041
Echinococcus granulosus	somatostatin receptor	0.0059	0.0041	0.0041
Echinococcus granulosus	G protein coupled receptor 139	0.0059	0.0041	0.0041
Schistosoma mansoni	biogenic amine receptor	0.0059	0.0041	0.0041
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.249	0.2577	0.2577
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0015	0.0015
Schistosoma mansoni	neuropeptide F-like receptor	0.0059	0.0041	0.0041
Echinococcus multilocularis	Rab geranylgeranyltransferase, beta subunit	0.0378	0.0374	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0808	0.0822	0.0822
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0059	0.0041	0.0041
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0808	0.0822	0.0822
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0789	0.0803	0.0803
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0005	0.0019
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0059	0.0041	0.0041
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.9605	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Echinococcus granulosus	serotonin receptor	0.0059	0.0041	0.0041
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.1394	0.1434	0.1434
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.249	0.2577	0.2577
Loa Loa (eye worm)	hypothetical protein	0.0789	0.0803	0.0803
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0015
Brugia malayi	Melatonin receptor type 1A	0.0059	0.0041	0.0041
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0059	0.0041	0.0041
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.249	0.2577	0.2577
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Echinococcus granulosus	g protein coupled receptor	0.0059	0.0041	0.0041
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.249	0.2577	0.2566
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0808	0.0822	0.0822
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0808	0.0822	0.0822
Brugia malayi	hypothetical protein	0.0059	0.0041	0.0041
Schistosoma mansoni	sodium/chloride dependent transporter	0.0808	0.0822	0.0822
Mycobacterium tuberculosis	Halimadienyl diphosphate synthase	0.0378	0.0374	1
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.002	0	0.5
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0808	0.0822	0.0822
Echinococcus granulosus	neuropeptide s receptor	0.0059	0.0041	0.0041
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0059	0.0041	0.0041
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.1394	0.1434	0.143
Echinococcus granulosus	neuropeptide receptor	0.0059	0.0041	0.0041
Brugia malayi	TAR-binding protein	0.0064	0.0046	0.0046
Brugia malayi	sulfakinin receptor protein	0.0059	0.0041	0.0041
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0808	0.0822	0.0822
Schistosoma mansoni	myosin xvIII	0.0059	0.0041	0.0041
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.0041	0.0041
Echinococcus multilocularis	orexin receptor type 2	0.0059	0.0041	0.0041
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.002	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0378	0.0374	0.0374
Schistosoma mansoni	biogenic amine receptor	0.0059	0.0041	0.0041
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0808	0.0822	0.1111
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0378	0.0374	0.0374
Loa Loa (eye worm)	hypothetical protein	0.4758	0.4944	0.4944
Echinococcus granulosus	fmrfamide receptor	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Trypanosoma brucei	geranylgeranyl transferase type II beta subunit, putative	0.0378	0.0374	0.1451
Giardia lamblia	Rab geranylgeranyltransferase	0.249	0.2577	0.2289
Brugia malayi	G-protein coupled receptor	0.0059	0.0041	0.0041
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Echinococcus multilocularis	serotonin receptor	0.0789	0.0803	0.0803
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0808	0.0822	0.5
Loa Loa (eye worm)	TYRA-2 protein	0.0059	0.0041	0.0041
Brugia malayi	hypothetical protein	0.0059	0.0041	0.0041
Schistosoma mansoni	hypothetical protein	0.0034	0.0015	0.0015
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.1394	0.1434	0.1434
Schistosoma mansoni	amine GPCR	0.0059	0.0041	0.0041
Schistosoma mansoni	opsin-like receptor	0.0059	0.0041	0.0041
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	0.0378	0.0374	0.0374
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.1394	0.1434	0.1937
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0041	0.0041
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0037	0.0018	0.0018
Loa Loa (eye worm)	serotonin transporter b	0.4758	0.4944	0.4944
Loa Loa (eye worm)	transcription factor SMAD2	0.0137	0.0123	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0378	0.0374	0.0359
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.002	0	0.5
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.1016	0.1039	0.1035
Brugia malayi	hypothetical protein	0.0141	0.0127	0.0127
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0059	0.0041	0.0041
Plasmodium vivax	amine transporter, putative	0.0808	0.0822	0.0818
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.249	0.2577	0.2577
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0808	0.0822	0.0822
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0378	0.0374	0.0374
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0808	0.0822	0.0822
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0059	0.0041	0.0041
Echinococcus multilocularis	g protein coupled receptor	0.0059	0.0041	0.0041
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0015	0.0015
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0108	0.0093	0.0093
Brugia malayi	hypothetical protein	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0808	0.0822	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0059	0.0041	0.0041
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0808	0.0822	0.0822
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0059	0.0041	0.0041
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.249	0.2577	0.2577
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.0041	0.0041
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0059	0.0041	0.0041
Echinococcus granulosus	neuropeptide FF receptor 2	0.0059	0.0041	0.0041
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0808	0.0822	0.1111
Brugia malayi	G-protein coupled receptor	0.0059	0.0041	0.0041
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0059	0.0041	0.0041
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0808	0.0822	0.0822
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.249	0.2577	0.2577
Onchocerca volvulus		0.0808	0.0822	0.1593
Loa Loa (eye worm)	hypothetical protein	0.4758	0.4944	0.4944
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0059	0.0041	0.0041
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0059	0.0041	0.0041
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.002	0	0.5
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0378	0.0374	0.0505
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0046	0.0046
Brugia malayi	neuropeptide F receptor	0.0059	0.0041	0.0041
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.1394	0.1434	0.142
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0808	0.0822	0.0822
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.9605	1	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0015	0.0015
Schistosoma mansoni	sodium/chloride dependent transporter	0.0808	0.0822	0.0822
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0046	0.0046
Trypanosoma cruzi	hypothetical protein, conserved	0.0378	0.0374	0.1451
Echinococcus multilocularis	fmrfamide receptor	0.0059	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0041	0.0041
Echinococcus multilocularis	G protein coupled receptor 139	0.0059	0.0041	0.0041
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0378	0.0374	0.0374
Plasmodium falciparum	geranylgeranyl transferase type2 beta subunit, putative	0.0378	0.0374	0.0369
Echinococcus multilocularis	g-protein coupled receptor	0.0059	0.0041	0.0041
Echinococcus multilocularis	serotonin transporter	0.4758	0.4944	0.4944
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0046	0.0046
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0041	0.0041
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0059	0.0041	0.0041
Echinococcus granulosus	neuropeptide receptor	0.0059	0.0041	0.0041
Echinococcus granulosus	sodium and chloride dependent glycine	0.0808	0.0822	0.0822
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0059	0.0041	0.0041
Echinococcus granulosus	serotonin transporter	0.4758	0.4944	0.4944
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0059	0.0041	0.0041
Loa Loa (eye worm)	G-protein coupled receptor	0.0059	0.0041	0.0041
Trypanosoma cruzi	protein farnesyltransferase, putative	0.1394	0.1434	0.5563
Brugia malayi	hypothetical protein	0.0059	0.0041	0.0041
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0378	0.0374	0.0359
Plasmodium falciparum	geranylgeranyltransferase, putative	0.0378	0.0374	0.0369
Echinococcus granulosus	rhodopsin orphan GPCR	0.0059	0.0041	0.0041
Toxoplasma gondii	hypothetical protein	0.249	0.2577	0.3482
Echinococcus granulosus	neuropeptide Y receptor	0.0059	0.0041	0.0041
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.002	0	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0108	0.0093	0.0093
Plasmodium falciparum	transporter, putative	0.0808	0.0822	0.0818
Onchocerca volvulus	Huntingtin homolog	0.0141	0.0127	0.0174
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.002	0	0.5
Brugia malayi	putative neuropeptide receptor	0.0059	0.0041	0.0041
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0059	0.0041	0.0041

Activities

Activity type	Activity value	Assay description	Source	Reference
Basal binding (binding)	= 78 %	Efficacy of the compound at cloned human opioid receptor delta 1, expressed as percent of basal binding	ChEMBL.	14711299
Basal binding (binding)	= 78 %	Efficacy of the compound at cloned human opioid receptor delta 1, expressed as percent of basal binding	ChEMBL.	14711299
IC50 (functional)	= 15.2 nM	Inverse agonist potency of the compound at cloned human opioid receptor delta 1	ChEMBL.	14711299
IC50 (functional)	= 15.2 nM	Inverse agonist potency of the compound at cloned human opioid receptor delta 1	ChEMBL.	14711299
Ke (functional)	= 4.24 nM	Ability to inhibit agonist-stimulated (DPDPE) [35S]-GTP-gammaS, binding, using cloned human opioid receptor delta 1 expressed in CHO cells	ChEMBL.	14711299
Ke (functional)	= 4.24 nM	Ability to inhibit agonist-stimulated (DPDPE) [35S]-GTP-gammaS, binding, using cloned human opioid receptor delta 1 expressed in CHO cells	ChEMBL.	14711299
Ke (functional)	= 5.51 nM	Ability to inhibit agonist-stimulated (U69,593) [35S]-GTP-gammaS, binding, using cloned human Opioid receptor kappa 1 expressed in CHO cells	ChEMBL.	14711299
Ke (functional)	= 5.51 nM	Ability to inhibit agonist-stimulated (U69,593) [35S]-GTP-gammaS, binding, using cloned human Opioid receptor kappa 1 expressed in CHO cells	ChEMBL.	14711299
Ke (functional)	= 40.3 nM	Ability to inhibit agonist-stimulated (DAMGO) [35S]-GTP-gammaS, binding, using cloned human Opioid receptor mu 1 expressed in CHO cells	ChEMBL.	14711299
Ke (functional)	= 40.3 nM	Ability to inhibit agonist-stimulated (DAMGO) [35S]-GTP-gammaS, binding, using cloned human Opioid receptor mu 1 expressed in CHO cells	ChEMBL.	14711299
Ki (binding)	= 9.3 nM	[3H]-Cl-DPDPE competition binding assay using human cloned opioid receptor delta 1	ChEMBL.	14711299
Ki (binding)	= 9.3 nM	[3H]-Cl-DPDPE competition binding assay using human cloned opioid receptor delta 1	ChEMBL.	14711299
Selectivity ratio (functional)	= 1.3	Selectivity ratio of agonist stimulated [35S]-GTP-gammaS, binding in cloned human kappa-opioid receptor versus delta-opioid receptor	ChEMBL.	14711299
Selectivity ratio (functional)	= 9.5	Selectivity ratio of agonist stimulated [35S]-GTP-gammaS, binding in cloned human mu-opioid receptor versus delta-opioid receptor	ChEMBL.	14711299

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL329754

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 159141