Detailed information for compound 1603744

Basic information

Technical information
  • TDR Targets ID: 1603744
  • Name: 3-methylidenecyclopropane-1,2-dicarboxylic ac id
  • MW: 142.109 | Formula: C6H6O4
  • H donors: 2 H acceptors: 4 LogP: -0.54 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C1C(=C)C1C(=O)O
  • InChi: 1S/C6H6O4/c1-2-3(5(7)8)4(2)6(9)10/h3-4H,1H2,(H,7,8)(H,9,10)
  • InChiKey: XZVHROKAQFFOCA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-Methylenecyclopropane-1,2-dicarboxylic acid
  • 3-Methylenecyclopropane-trans-1,2-dicarboxylic acid
  • ST5308456
  • trans-1-Methylene cyclopropane-2,3-dicarboxylic acid
  • NCI60_006704
  • 3-Methylene-1,2-cyclopropanedicarboxylic acid
  • AIDS-131249
  • AIDS131249
  • NSC622663
  • EINECS 207-874-4
  • NSC 622663
  • trans-3-Methylenecyclopropane-1,2-dicarboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus g protein coupled receptor 0.1205 0.2198 0.2233
Brugia malayi hypothetical protein 0.0042 0.005 0.0039
Schistosoma mansoni biogenic amine receptor 0.1205 0.2198 0.6608
Toxoplasma gondii beta tubulin 0.1557 0.2849 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1205 0.2198 0.6608
Loa Loa (eye worm) insulin-degrading enzyme 0.0025 0.0018 0.0021
Brugia malayi Pepsin A precursor 0.0023 0.0014 0.0003
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.1205 0.2198 0.2233
Schistosoma mansoni adenoreceptor 0.1205 0.2198 0.6608
Loa Loa (eye worm) hypothetical protein 0.0042 0.005 0.0116
Trypanosoma cruzi AMP deaminase, putative 0.0028 0.0024 0.0022
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.0086 0.0131 1
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Onchocerca volvulus Cirhin homolog 0.0188 0.0321 0.1147
Trichomonas vaginalis adenosine deaminase, putative 0.0086 0.0131 0.0424
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Echinococcus multilocularis CD36 class B scavenger receptor 0.0042 0.005 0.0051
Schistosoma mansoni histamine h1 receptor 0.1205 0.2198 0.6608
Leishmania major beta tubulin 0.1557 0.2849 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.005 0.0116
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Plasmodium falciparum plasmepsin VII 0.0023 0.0014 0.0011
Schistosoma mansoni alpha-1 adrenergic receptor 0.1205 0.2198 0.6608
Brugia malayi hypothetical protein 0.1205 0.2198 0.2189
Brugia malayi Tachykinin-like peptides receptor 99D 0.1205 0.2198 0.2189
Brugia malayi hypothetical protein 0.1205 0.2198 0.2189
Echinococcus granulosus insulin degrading enzyme 0.0025 0.0018 0.0007
Onchocerca volvulus 0.1205 0.2198 0.8103
Echinococcus multilocularis Tubulin beta 2C chain 0.1557 0.2849 0.2905
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.0028
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Brugia malayi G protein-coupled receptor F59B2.13 0.1205 0.2198 0.2189
Echinococcus multilocularis CD36 class B scavenger receptor 0.0042 0.005 0.0051
Schistosoma mansoni adenosine deaminase 0.0086 0.0131 0.0363
Leishmania major beta tubulin 0.1557 0.2849 1
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.1205 0.2198 0.2242
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1205 0.2198 0.2233
Toxoplasma gondii beta-1 tubulin, putative 0.1557 0.2849 1
Echinococcus granulosus Tubulin beta 2C chain 0.1557 0.2849 0.2897
Schistosoma mansoni tubulin subunit beta 0.1557 0.2849 0.8573
Echinococcus granulosus tubulin subunit beta 0.1557 0.2849 0.2897
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Schistosoma mansoni beta-catenin 0.019 0.0323 0.0943
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.1205 0.2198 0.2189
Echinococcus multilocularis alpha 1A adrenergic receptor 0.1205 0.2198 0.2242
Trypanosoma brucei beta tubulin 0.1557 0.2849 1
Plasmodium falciparum cysteine repeat modular protein 4 0.0026 0.002 0.0033
Trypanosoma brucei AMP deaminase, putative 0.0028 0.0024 0.0022
Brugia malayi hypothetical protein 0.1205 0.2198 0.2189
Giardia lamblia Beta tubulin 0.1557 0.2849 1
Schistosoma mansoni cd36 antigen 0.0042 0.005 0.0118
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Brugia malayi hypothetical protein 0.1842 0.3374 0.3367
Echinococcus granulosus neuropeptide Y receptor 0.1205 0.2198 0.2233
Loa Loa (eye worm) runx1 0.0058 0.008 0.0206
Echinococcus granulosus orexin receptor type 2 0.1205 0.2198 0.2233
Leishmania major AMP deaminase, putative 0.0028 0.0024 0.0022
Brugia malayi GCC2 and GCC3 family protein 0.0026 0.002 0.0009
Echinococcus granulosus beta catenin 0.019 0.0323 0.0319
Entamoeba histolytica tubulin family protein 0.1557 0.2849 1
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.1205 0.2198 0.8103
Leishmania major hypothetical protein, conserved 0.0028 0.0024 0.0022
Trypanosoma cruzi adenosine monophosphate deaminase-like protein, putative 0.0028 0.0024 0.0022
Schistosoma mansoni biogenic amine (5HT) receptor 0.1205 0.2198 0.6608
Trypanosoma brucei AMP deaminase, putative 0.0028 0.0024 0.0022
Leishmania major beta tubulin 0.1557 0.2849 1
Schistosoma mansoni amine GPCR 0.1205 0.2198 0.6608
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.1205 0.2198 0.2242
Schistosoma mansoni hypothetical protein 0.1205 0.2198 0.6608
Loa Loa (eye worm) hypothetical protein 0.1482 0.271 0.8026
Onchocerca volvulus 0.0023 0.0014 0.0012
Echinococcus multilocularis prolyl endopeptidase 0.0127 0.0208 0.0212
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0051 0.0066 0.017
Plasmodium vivax aspartyl protease, putative 0.0023 0.0014 0.0011
Loa Loa (eye worm) tubulin beta-1 chain 0.1557 0.2849 0.8438
Echinococcus multilocularis G-protein coupled receptor, putative 0.1205 0.2198 0.2242
Echinococcus granulosus rhodopsin orphan GPCR 0.1205 0.2198 0.2233
Loa Loa (eye worm) hypothetical protein 0.0887 0.161 0.4756
Brugia malayi CD36 family protein 0.0042 0.005 0.0039
Echinococcus multilocularis rhodopsin orphan GPCR 0.1205 0.2198 0.2242
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1205 0.2198 0.2242
Schistosoma mansoni ephrin receptor 0.0109 0.0174 0.0494
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Trypanosoma cruzi AMP deaminase, putative 0.0028 0.0024 0.0022
Echinococcus multilocularis serotonin receptor 0.1205 0.2198 0.2242
Trypanosoma cruzi AMP deaminase 2, putative 0.0028 0.0024 0.0022
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1205 0.2198 0.6608
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0281 0.0491 0.05
Brugia malayi hypothetical protein 0.1205 0.2198 0.2189
Plasmodium vivax plasmepsin IV, putative 0.0095 0.0148 0.0484
Trypanosoma brucei RNA helicase, putative 0.0664 0.12 0.4175
Plasmodium falciparum plasmepsin III 0.0023 0.0014 0.0011
Echinococcus multilocularis G protein coupled receptor 139 0.1813 0.3321 0.3387
Echinococcus multilocularis g protein coupled receptor 0.1205 0.2198 0.2242
Brugia malayi GCC2 and GCC3 family protein 0.0026 0.002 0.0009
Trypanosoma cruzi AMP deaminase, putative 0.0028 0.0024 0.0022
Brugia malayi Serotonin receptor 0.1205 0.2198 0.2189
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1205 0.2198 0.2189
Echinococcus granulosus beta tubulin 0.1557 0.2849 0.2897
Brugia malayi hypothetical protein 0.0465 0.0831 0.0821
Schistosoma mansoni opsin-like receptor 0.1205 0.2198 0.6608
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0014 0.001
Echinococcus multilocularis Tubulin beta 2C chain 0.1557 0.2849 0.2905
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.1205 0.2198 0.2189
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.1205 0.2198 0.6503
Echinococcus multilocularis fmrfamide receptor 0.1205 0.2198 0.2242
Echinococcus granulosus rhodopsin orphan GPCR 0.1205 0.2198 0.2233
Leishmania major beta tubulin 0.1557 0.2849 1
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Leishmania major beta tubulin 0.1557 0.2849 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1205 0.2198 0.6608
Echinococcus granulosus CD36 class B scavenger receptor 0.0042 0.005 0.004
Brugia malayi Adenosine/AMP deaminase family protein 0.0086 0.0131 0.012
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1557 0.2849 0.2905
Onchocerca volvulus 0.1205 0.2198 0.8103
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0281 0.0491 0.049
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.0027
Schistosoma mansoni tubulin subunit beta 0.1557 0.2849 0.8573
Echinococcus granulosus rhodopsin orphan GPCR 0.1205 0.2198 0.2233
Loa Loa (eye worm) G-protein coupled receptor 0.1205 0.2198 0.6503
Loa Loa (eye worm) hypothetical protein 0.0042 0.005 0.0116
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.1205 0.2198 0.2189
Echinococcus granulosus neuropeptide receptor A26 0.1205 0.2198 0.2233
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0281 0.0491 0.05
Echinococcus multilocularis sex peptide receptor 0.1205 0.2198 0.2242
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Brugia malayi neuropeptide F receptor 0.1205 0.2198 0.2189
Schistosoma mansoni neuropeptide receptor 0.1205 0.2198 0.6608
Schistosoma mansoni cathepsin D (A01 family) 0.0281 0.0491 0.145
Schistosoma mansoni amine GPCR 0.1205 0.2198 0.6608
Echinococcus granulosus rhodopsin orphan GPCR 0.1205 0.2198 0.2233
Echinococcus granulosus sodium channel protein 0.0039 0.0044 0.0034
Schistosoma mansoni neuropeptide f receptor 76f 0.1205 0.2198 0.6608
Loa Loa (eye worm) TYRA-2 protein 0.1205 0.2198 0.6503
Plasmodium vivax cysteine repeat modular protein 2, putative 0.0026 0.002 0.0033
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.1205 0.2198 0.6503
Loa Loa (eye worm) aspartyl protease 6 0.0023 0.0014 0.001
Echinococcus multilocularis GPCR, family 2 0.0281 0.0491 0.05
Plasmodium falciparum plasmepsin IV 0.0095 0.0148 0.0484
Onchocerca volvulus 0.1205 0.2198 0.8103
Echinococcus multilocularis CD36 class B scavenger receptor 0.0042 0.005 0.0051
Chlamydia trachomatis insulinase family protease III 0.0025 0.0018 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1205 0.2198 0.2233
Onchocerca volvulus 0.0026 0.002 0.0034
Schistosoma mansoni hypothetical protein 0.1205 0.2198 0.6608
Loa Loa (eye worm) hypothetical protein 0.0086 0.0131 0.0358
Echinococcus granulosus tm gpcr rhodopsin 0.5323 0.9805 1
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0021 0.0011 0.0011
Echinococcus granulosus adenosine deaminase 0.0086 0.0131 0.0123
Echinococcus multilocularis neuropeptide FF receptor 2 0.1205 0.2198 0.2242
Loa Loa (eye worm) tubulin beta-2A chain 0.1557 0.2849 0.8438
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0095 0.0148 0.0484
Brugia malayi G-protein coupled receptor 0.1205 0.2198 0.2189
Plasmodium vivax hypothetical protein, conserved 0.0026 0.002 0.0033
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1205 0.2198 0.2233
Onchocerca volvulus Neuropeptide F receptor homolog 0.1205 0.2198 0.8103
Schistosoma mansoni hypothetical protein 0.0606 0.1092 0.3267
Onchocerca volvulus 0.1205 0.2198 0.8103
Leishmania major beta tubulin 0.1557 0.2849 1
Brugia malayi larval opioid receptor 0.1205 0.2198 0.2189
Loa Loa (eye worm) glutaminase 0.0287 0.0503 0.1462
Trichomonas vaginalis adenosine deaminase, putative 0.0086 0.0131 0.0424
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Schistosoma mansoni neuropeptide receptor 0.1205 0.2198 0.6608
Echinococcus multilocularis rhodopsin orphan GPCR 0.1205 0.2198 0.2242
Echinococcus multilocularis orexin receptor type 2 0.1205 0.2198 0.2242
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.1205 0.2198 0.6608
Schistosoma mansoni tubulin subunit beta 0.1557 0.2849 0.8573
Schistosoma mansoni peptide (allatostatin)-like receptor 0.1482 0.271 0.8155
Entamoeba histolytica AMP deaminase, putative 0.0028 0.0024 0.0014
Onchocerca volvulus 0.1205 0.2198 0.8103
Loa Loa (eye worm) hypothetical protein 0.0042 0.005 0.0116
Trichomonas vaginalis glutaminase, putative 0.0287 0.0503 0.1733
Echinococcus granulosus peptide allatostatin:somatostatin 0.1205 0.2198 0.2233
Echinococcus multilocularis Tubulin beta 2C chain 0.1557 0.2849 0.2905
Brugia malayi Armadillo/beta-catenin-like repeat family protein 0.019 0.0323 0.0312
Brugia malayi Dopamine receptor protein 1 0.1205 0.2198 0.2189
Trichomonas vaginalis tubulin beta chain, putative 0.1557 0.2849 1
Schistosoma mansoni opsin-like receptor 0.1205 0.2198 0.6608
Brugia malayi Dopamine receptor protein 2 0.1205 0.2198 0.2189
Leishmania major AMP deaminase, putative,amp deaminase-like protein 0.0028 0.0024 0.0022
Echinococcus multilocularis adenosine deaminase 0.0086 0.0131 0.0134
Onchocerca volvulus 0.1205 0.2198 0.8103
Schistosoma mansoni tubulin subunit beta 0.1557 0.2849 0.8573
Loa Loa (eye worm) hypothetical protein 0.0108 0.0172 0.048
Brugia malayi Dopamine receptor 0.1205 0.2198 0.2189
Plasmodium falciparum plasmepsin VI 0.0095 0.0148 0.0484
Schistosoma mansoni biogenic amine (5HT) receptor 0.1205 0.2198 0.6608
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0095 0.0148 0.0151
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Plasmodium falciparum AMP deaminase, putative 0.0028 0.0024 0.0047
Schistosoma mansoni amine GPCR 0.1205 0.2198 0.6608
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Trypanosoma brucei prolyl oligopeptidase, putative 0.0051 0.0066 0.017
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1205 0.2198 0.6608
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0051 0.0066 0.017
Trypanosoma brucei beta tubulin 0.1557 0.2849 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1205 0.2198 0.6608
Echinococcus multilocularis tubulin beta 1 chain 0.1557 0.2849 0.2905
Echinococcus granulosus membrane associated guanylate kinase, WW and PDZ 0.0025 0.0019 0.0008
Trypanosoma brucei beta tubulin 0.1557 0.2849 1
Echinococcus granulosus Tubulin beta 2C chain 0.1557 0.2849 0.2897
Trypanosoma cruzi AMP deaminase, putative 0.0028 0.0024 0.0022
Brugia malayi putative neuropeptide receptor NPR1 0.1205 0.2198 0.2189
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1205 0.2198 0.2242
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1205 0.2198 0.6608
Trypanosoma cruzi prolyl endopeptidase 0.0127 0.0208 0.067
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0086 0.0131 0.046
Trypanosoma cruzi oligopeptidase b 0.0051 0.0066 0.017
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.1205 0.2198 0.6608
Echinococcus multilocularis nardilysin 0.0025 0.0018 0.0018
Schistosoma mansoni biogenic amine receptor 0.1205 0.2198 0.6608
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0014 0.001
Echinococcus granulosus biogenic amine 5HT receptor 0.1205 0.2198 0.2233
Echinococcus granulosus Tubulin beta 2C chain 0.1557 0.2849 0.2897
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.1205 0.2198 0.2233
Onchocerca volvulus 0.0028 0.0024 0.0049
Brugia malayi aspartic protease BmAsp-2, identical 0.0023 0.0014 0.0003
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0039 0.0044 0.0034
Plasmodium falciparum tubulin beta chain 0.1557 0.2849 1
Leishmania major beta tubulin 0.1557 0.2849 1
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Onchocerca volvulus 0.0023 0.0014 0.0012
Loa Loa (eye worm) melatonin receptor type 1A 0.1205 0.2198 0.6503
Onchocerca volvulus 0.1205 0.2198 0.8103
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Leishmania major adenosine monophosphate deaminase, putative,AMP deaminase, putative 0.0028 0.0024 0.0022
Giardia lamblia Beta tubulin 0.1557 0.2849 1
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Plasmodium vivax aspartyl proteinase, putative 0.0095 0.0148 0.0484
Loa Loa (eye worm) neuropeptide F receptor 0.1205 0.2198 0.6503
Brugia malayi Melatonin receptor type 1A 0.1205 0.2198 0.2189
Echinococcus multilocularis membrane associated guanylate kinase, WW and PDZ 0.0025 0.0019 0.0019
Echinococcus multilocularis rhodopsin orphan GPCR 0.1205 0.2198 0.2242
Schistosoma mansoni hypothetical protein 0.0664 0.12 0.3592
Echinococcus multilocularis Protein lozenge 0.0058 0.008 0.0082
Plasmodium falciparum cysteine repeat modular protein 1 0.0026 0.002 0.0033
Echinococcus multilocularis g protein coupled receptor 0.1205 0.2198 0.2242
Plasmodium falciparum plasmepsin IX 0.0023 0.0014 0.0011
Loa Loa (eye worm) G-protein coupled receptor 0.1205 0.2198 0.6503
Plasmodium falciparum plasmepsin X 0.0023 0.0014 0.0011
Echinococcus multilocularis SWI:SNF matrix associated 0.0021 0.0011 0.0011
Leishmania major beta tubulin 0.1557 0.2849 1
Plasmodium vivax plasmepsin V, putative 0.0023 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0014 0.001
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.1205 0.2198 0.6503
Echinococcus granulosus 7TM GPCR rhodopsin 0.1205 0.2198 0.2233
Echinococcus multilocularis beta tubulin 0.1557 0.2849 0.2905
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.001
Trichomonas vaginalis tubulin epsilon chain, putative 0.1557 0.2849 1
Echinococcus multilocularis CD36 class B scavenger receptor 0.0042 0.005 0.0051
Onchocerca volvulus 0.1205 0.2198 0.8103
Echinococcus multilocularis tachykinin peptides receptor 99D 0.1205 0.2198 0.2242
Echinococcus granulosus tm gpcr rhodopsin 0.1205 0.2198 0.2233
Schistosoma mansoni nardilysin (M16 family) 0.0025 0.0018 0.0021
Echinococcus multilocularis dro:myosuppressin receptor 0.1205 0.2198 0.2242
Plasmodium vivax aspartyl protease, putative 0.0023 0.0014 0.0011
Brugia malayi hypothetical protein 0.0023 0.0014 0.0003
Plasmodium falciparum plasmepsin VIII, putative 0.0023 0.0014 0.0011
Trichomonas vaginalis tubulin epsilon chain, putative 0.1557 0.2849 1
Schistosoma mansoni hypothetical protein 0.0281 0.0491 0.145
Onchocerca volvulus 0.1205 0.2198 0.8103
Echinococcus multilocularis fmrfamide receptor 0.1205 0.2198 0.2242
Echinococcus granulosus g protein coupled receptor 0.1205 0.2198 0.2233
Brugia malayi hypothetical protein 0.0042 0.005 0.0039
Loa Loa (eye worm) hypothetical protein 0.0127 0.0208 0.0585
Brugia malayi G protein-coupled receptor 0.1205 0.2198 0.2189
Echinococcus granulosus serotonin receptor 0.1205 0.2198 0.2233
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0014 0.001
Schistosoma mansoni hypothetical protein 0.0281 0.0491 0.145
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Brugia malayi insulin-degrading enzyme 0.0025 0.0018 0.0007
Toxoplasma gondii AMP deaminase 0.0028 0.0024 0.0085
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1205 0.2198 0.2242
Trypanosoma cruzi AMP deaminase, putative 0.0028 0.0024 0.0022
Giardia lamblia Beta tubulin 0.1557 0.2849 1
Echinococcus granulosus Tubulin beta 2C chain 0.1557 0.2849 0.2897
Schistosoma mansoni memapsin-2 (A01 family) 0.0023 0.0014 0.001
Plasmodium vivax hypothetical protein, conserved 0.0026 0.002 0.0033
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.0086 0.0131 0.046
Echinococcus multilocularis Tubulin beta 2C chain 0.1557 0.2849 0.2905
Echinococcus granulosus rhodopsin orphan GPCR 0.1205 0.2198 0.2233
Echinococcus granulosus somatostatin receptor 0.1205 0.2198 0.2233
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0014 0.001
Plasmodium falciparum cysteine repeat modular protein 2 0.0026 0.002 0.0033
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0023 0.0014 0.001
Echinococcus multilocularis CD36 class B scavenger receptor 0.0042 0.005 0.0051
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0025 0.0018 0.0021
Onchocerca volvulus 0.1205 0.2198 0.8103
Trypanosoma cruzi oligopeptidase b 0.0051 0.0066 0.017
Onchocerca volvulus AMP deaminase 2 homolog 0.0028 0.0024 0.0049
Schistosoma mansoni tubulin subunit beta 0.1557 0.2849 0.8573
Echinococcus granulosus CD36 class B scavenger receptor 0.0042 0.005 0.004
Leishmania major beta tubulin 0.1557 0.2849 1
Toxoplasma gondii prolyl endopeptidase 0.0127 0.0208 0.0729
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1205 0.2198 0.6608
Leishmania major oligopeptidase b 0.0051 0.0066 0.017
Echinococcus granulosus ephrin type A receptor 4 A 0.0135 0.0222 0.0216
Echinococcus granulosus 3'partial|nardilysin 0.0025 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0058 0.0079 0.0204
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Echinococcus granulosus CD36 class B scavenger receptor 0.0042 0.005 0.004
Loa Loa (eye worm) beta-tubulin 0.1557 0.2849 0.8438
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0025 0.0018 0.0021
Echinococcus granulosus alpha 1A adrenergic receptor 0.1205 0.2198 0.2233
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0021 0.0011 0.0038
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Toxoplasma gondii rhoptry metalloprotease toxolysin TLN1 0.0025 0.0018 0.0063
Plasmodium vivax tubulin beta chain, putative 0.1557 0.2849 1
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Toxoplasma gondii GCC2 and GCC3 domain-containing protein 0.0026 0.002 0.007
Echinococcus granulosus 7tm_1 domain containing protein 0.1205 0.2198 0.2233
Echinococcus multilocularis biogenic amine (5HT) receptor 0.1205 0.2198 0.2242
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Loa Loa (eye worm) hypothetical protein 0.0465 0.0831 0.244
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.1205 0.2198 0.6608
Echinococcus multilocularis rhodopsin orphan GPCR 0.1205 0.2198 0.2242
Brugia malayi gonadotropin-releasing hormone receptor 2 0.1205 0.2198 0.2189
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Plasmodium falciparum plasmepsin I 0.0095 0.0148 0.0484
Loa Loa (eye worm) hypothetical protein 0.0058 0.0079 0.0204
Onchocerca volvulus 0.1482 0.271 1
Schistosoma mansoni amine GPCR 0.1205 0.2198 0.6608
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0035 0.0037 0.0027
Echinococcus multilocularis rhodopsin orphan GPCR 0.1205 0.2198 0.2242
Echinococcus granulosus tubulin beta 4A class IVa 0.1557 0.2849 0.2897
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1205 0.2198 0.6608
Schistosoma mansoni nardilysin (M16 family) 0.0025 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0042 0.005 0.0116
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.1205 0.2198 0.6503
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0281 0.0491 0.048
Loa Loa (eye worm) AMP deaminase 0.0028 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.0027
Echinococcus multilocularis sodium channel protein 0.0039 0.0044 0.0045
Plasmodium vivax cysteine repeat modular protein 3, putative 0.0026 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0023 0.0014 0.0049
Toxoplasma gondii hypothetical protein 0.0026 0.002 0.007
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0051 0.0066 0.017
Echinococcus multilocularis neuropeptide s receptor 0.1205 0.2198 0.2242
Onchocerca volvulus 0.1205 0.2198 0.8103
Echinococcus granulosus neuropeptide s receptor 0.1205 0.2198 0.2233
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0051 0.0066 0.017
Brugia malayi Eukaryotic aspartyl protease family protein 0.0023 0.0014 0.0003
Onchocerca volvulus 0.1205 0.2198 0.8103
Echinococcus granulosus CD36 class B scavenger receptor 0.0042 0.005 0.004
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.1205 0.2198 0.2242
Trypanosoma cruzi adenosine monophosphate deaminase, putative 0.0028 0.0024 0.0022
Brugia malayi hypothetical protein 0.0023 0.0014 0.0003
Echinococcus multilocularis ephrin type A receptor 4 A 0.0135 0.0222 0.0226
Brugia malayi Tubulin beta-1 chain 0.1557 0.2849 0.2841
Leishmania major beta tubulin 0.1557 0.2849 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.5323 0.9805 1
Schistosoma mansoni hypothetical protein 0.1205 0.2198 0.6608
Trypanosoma brucei oligopeptidase b 0.0051 0.0066 0.017
Plasmodium falciparum plasmepsin II 0.0095 0.0148 0.0484
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Echinococcus granulosus tm gpcr rhodopsin 0.1205 0.2198 0.2233
Entamoeba histolytica adenosine deaminase, putative 0.0086 0.0131 0.0392
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1205 0.2198 0.6608
Loa Loa (eye worm) BEN-1 protein 0.1557 0.2849 0.8438
Loa Loa (eye worm) hypothetical protein 0.1842 0.3374 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0887 0.161 0.4756
Schistosoma mansoni lozenge 0.0058 0.008 0.021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1205 0.2198 0.6608
Brugia malayi adenosine monophosphate deaminase 0.0028 0.0024 0.0013
Loa Loa (eye worm) hypothetical protein 0.0465 0.0831 0.244
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.0027
Schistosoma mansoni neuropeptide receptor 0.1813 0.3321 1
Echinococcus granulosus neuropeptide FF receptor 2 0.1205 0.2198 0.2233
Plasmodium vivax adenosine deaminase, putative 0.0086 0.0131 0.0424
Brugia malayi G-protein coupled receptor 0.1205 0.2198 0.2189
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0095 0.0148 0.0521
Loa Loa (eye worm) hypothetical protein 0.0095 0.0148 0.0409
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1205 0.2198 0.6608
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1205 0.2198 0.6608
Onchocerca volvulus Lysosome membrane protein 2 homolog 0.0042 0.005 0.0145
Toxoplasma gondii beta-tubulin, putative 0.1557 0.2849 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.1205 0.2198 0.2233
Brugia malayi glutaminase DH11.1 0.0287 0.0503 0.0492
Leishmania major beta tubulin 0.1557 0.2849 1
Echinococcus granulosus neuropeptide receptor 0.1813 0.3321 0.3379
Trypanosoma brucei AMP deaminase, putative 0.0028 0.0024 0.0022
Echinococcus multilocularis neuropeptide receptor 0.1813 0.3321 0.3387
Echinococcus multilocularis endonuclease reverse transcriptase 0.0026 0.002 0.002
Loa Loa (eye worm) tubulin beta chain 0.1557 0.2849 0.8438
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.1205 0.2198 0.2242
Schistosoma mansoni myosin xvIII 0.1205 0.2198 0.6608
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0014 0.001
Echinococcus multilocularis beta tubulin 0.1557 0.2849 0.2905
Entamoeba histolytica adenosine deaminase, putative 0.0086 0.0131 0.0392
Echinococcus granulosus prolyl endopeptidase 0.0127 0.0208 0.0201
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0127 0.0208 0.0595
Mycobacterium ulcerans adenosine deaminase 0.0086 0.0131 0.1491
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Echinococcus multilocularis tubulin subunit beta 0.1557 0.2849 0.2905
Echinococcus multilocularis serotonin receptor 0.1205 0.2198 0.2242
Loa Loa (eye worm) hypothetical protein 0.0025 0.0019 0.0024
Schistosoma mansoni neuropeptide receptor 0.1205 0.2198 0.6608
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0127 0.0208 0.067
Echinococcus multilocularis rhodopsin orphan GPCR 0.1205 0.2198 0.2242
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1205 0.2198 0.6608
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.1205 0.2198 0.2242
Toxoplasma gondii kringle domain-containing protein 0.0026 0.002 0.007
Echinococcus multilocularis neuropeptide receptor 0.1205 0.2198 0.2242
Brugia malayi latrophilin 2 splice variant baaae 0.0606 0.1092 0.1082
Loa Loa (eye worm) hypothetical protein 0.0058 0.0079 0.0204
Loa Loa (eye worm) glutaminase 2 0.0287 0.0503 0.1462
Toxoplasma gondii aspartyl protease ASP1 0.0095 0.0148 0.0521
Echinococcus granulosus sex peptide receptor 0.1205 0.2198 0.2233
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0035 0.0037 0.008
Schistosoma mansoni AMP deaminase 0.0028 0.0024 0.004
Echinococcus multilocularis SWI:SNF matrix associated 0.0021 0.0011 0.0011
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.1205 0.2198 0.6608
Loa Loa (eye worm) latrophilin receptor protein 2 0.0281 0.0491 0.1427
Plasmodium vivax adenosine/AMP deaminase, putative 0.0028 0.0024 0.0047
Schistosoma mansoni hypothetical protein 0.0281 0.0491 0.145
Echinococcus multilocularis nardilysin 0.0025 0.0018 0.0018
Echinococcus multilocularis g protein coupled receptor 0.1205 0.2198 0.2242
Echinococcus granulosus GPCR family 2 0.0281 0.0491 0.049
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.0086 0.0131 0.5562
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Plasmodium falciparum conserved protein, unknown function 0.0026 0.002 0.0033
Leishmania major beta tubulin 0.1557 0.2849 1
Entamoeba histolytica AMP deaminase, putative 0.0028 0.0024 0.0014
Echinococcus multilocularis g-protein coupled receptor 0.1205 0.2198 0.2242
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0014 0.001
Brugia malayi aspartic protease BmAsp-1, identical 0.0023 0.0014 0.0003
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Echinococcus multilocularis neuropeptide receptor A26 0.1205 0.2198 0.2242
Brugia malayi hypothetical protein 0.1205 0.2198 0.2189
Brugia malayi RE15519p 0.1205 0.2198 0.2189
Schistosoma mansoni CD36-like class B scavenger receptor 0.0042 0.005 0.0118
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.1205 0.2198 0.6608
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Leishmania major beta tubulin 0.1557 0.2849 1
Schistosoma mansoni amine GPCR 0.1205 0.2198 0.6608
Echinococcus granulosus endonuclease reverse transcriptase 0.0026 0.002 0.0009
Leishmania major beta tubulin 0.1557 0.2849 1
Plasmodium falciparum cysteine repeat modular protein 3 0.0026 0.002 0.0033
Schistosoma mansoni glutaminase 0.0287 0.0503 0.1486
Loa Loa (eye worm) hypothetical protein 0.0055 0.0074 0.0188
Brugia malayi putative neuropeptide receptor 0.1205 0.2198 0.2189
Brugia malayi ORL1-like opioid receptor 0.1205 0.2198 0.2189
Leishmania major adenine aminohydrolase 0.0086 0.0131 0.04
Brugia malayi Serotonin receptor 0.1205 0.2198 0.2189
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0021 0.0011 0.0038
Onchocerca volvulus Prolyl endopeptidase homolog 0.0127 0.0208 0.0729
Echinococcus multilocularis 0.0035 0.0037 0.0038
Echinococcus granulosus g protein coupled receptor 0.1205 0.2198 0.2233
Brugia malayi hypothetical protein 0.1205 0.2198 0.2189
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Plasmodium vivax aspartyl proteinase, putative 0.0023 0.0014 0.0011
Echinococcus multilocularis neuropeptide Y receptor 0.1205 0.2198 0.2242
Echinococcus multilocularis Tubulin beta 2C chain 0.1557 0.2849 0.2905
Plasmodium falciparum plasmepsin V 0.0023 0.0014 0.0011
Brugia malayi hypothetical protein 0.1205 0.2198 0.2189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1205 0.2198 0.6608
Leishmania major beta tubulin 0.1557 0.2849 1
Plasmodium vivax aspartyl protease, putative 0.0023 0.0014 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.1205 0.2198 0.2233
Loa Loa (eye worm) neuropeptide F receptor 0.1205 0.2198 0.6503
Echinococcus granulosus CD36 class B scavenger receptor 0.0042 0.005 0.004
Echinococcus granulosus lysosome membrane protein 2 0.0042 0.005 0.004
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Brugia malayi sulfakinin receptor protein 0.1842 0.3374 0.3367
Onchocerca volvulus Adenosine deaminase homolog 0.0086 0.0131 0.0445
Plasmodium falciparum adenosine deaminase 0.0086 0.0131 0.0424
Echinococcus multilocularis rhodopsin orphan GPCR 0.1205 0.2198 0.2242
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1446 0.2644 0.7829
Mycobacterium ulcerans glutaminase 0.0287 0.0503 1
Trichomonas vaginalis tubulin, putative 0.1557 0.2849 1
Brugia malayi beta-tubulin, identical 0.1557 0.2849 0.2841
Entamoeba histolytica tubulin family protein 0.1557 0.2849 1
Schistosoma mansoni scavenger receptor class B type-2 (sr-B2) 0.0042 0.005 0.0118
Echinococcus granulosus G protein coupled receptor 139 0.1205 0.2198 0.2233
Echinococcus granulosus AMP deaminase 2 0.0028 0.0024 0.0014
Echinococcus multilocularis neuropeptide Y receptor 0.1205 0.2198 0.2242
Echinococcus granulosus tubulin beta 1 chain 0.1557 0.2849 0.2897
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0127 0.0208 0.0595
Onchocerca volvulus 0.0465 0.0831 0.304
Brugia malayi Latrophilin receptor protein 2 0.0281 0.0491 0.048
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1205 0.2198 0.6608
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Echinococcus granulosus dro:myosuppressin receptor 0.1205 0.2198 0.2233
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.1205 0.2198 0.2242
Echinococcus granulosus Tubulin beta 2C chain 0.1557 0.2849 0.2897
Brugia malayi hypothetical protein 0.1205 0.2198 0.2189
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Onchocerca volvulus 0.0026 0.002 0.0034
Trypanosoma brucei beta tubulin 0.1557 0.2849 1
Onchocerca volvulus 0.1205 0.2198 0.8103
Schistosoma mansoni tubulin subunit beta 0.1557 0.2849 0.8573
Leishmania major AMP deaminase, putative,adenosine monophosphate deaminase-like protein 0.0028 0.0024 0.0022
Echinococcus granulosus tachykinin peptides receptor 99D 0.1205 0.2198 0.2233
Toxoplasma gondii sporozoite developmental protein 0.0025 0.0018 0.0063
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Onchocerca volvulus 0.1205 0.2198 0.8103
Schistosoma mansoni hypothetical protein 0.0026 0.002 0.0028
Trichomonas vaginalis tubulin gamma chain, putative 0.1557 0.2849 1
Echinococcus multilocularis lysosome membrane protein 2 0.0042 0.005 0.0051
Schistosoma mansoni adenosine deaminase-related 0.0086 0.0131 0.0363
Schistosoma mansoni growth hormone secretagogue receptor 0.1205 0.2198 0.6608
Leishmania major beta tubulin 0.1557 0.2849 1
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Echinococcus granulosus allatostatin A receptor 0.1482 0.271 0.2756
Echinococcus granulosus 3'partial|membrane associated guanylate kinase ww and pdz 0.0025 0.0019 0.0008
Echinococcus granulosus hypothetical protein 0.1205 0.2198 0.2233
Echinococcus multilocularis membrane associated guanylate kinase ww and pdz 0.0025 0.0019 0.0019
Echinococcus granulosus nardilysin 0.0025 0.0018 0.0007
Brugia malayi Calcitonin receptor-like protein seb-1 0.0887 0.161 0.1601
Echinococcus granulosus neuropeptide receptor 0.1205 0.2198 0.2233
Loa Loa (eye worm) hypothetical protein 0.0058 0.0079 0.0204
Trichomonas vaginalis tubulin alpha chain, putative 0.1557 0.2849 1
Toxoplasma gondii aspartyl protease 0.0023 0.0014 0.0049
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0281 0.0491 0.049
Schistosoma mansoni hypothetical protein 0.1205 0.2198 0.6608
Loa Loa (eye worm) BEN-1 protein 0.1557 0.2849 0.8438
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1205 0.2198 0.2242
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0095 0.0148 0.0415
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Loa Loa (eye worm) hypothetical protein 0.0281 0.0491 0.1427
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0095 0.0148 0.014
Onchocerca volvulus 0.0108 0.0172 0.0598
Brugia malayi hypothetical protein 0.1205 0.2198 0.2189
Treponema pallidum adenosine deaminase 0.0086 0.0131 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.1205 0.2198 0.6608
Brugia malayi follicle stimulating hormone receptor 0.1446 0.2644 0.2636
Schistosoma mansoni hypothetical protein 0.0281 0.0491 0.145
Echinococcus multilocularis somatostatin receptor 0.1205 0.2198 0.2242
Echinococcus granulosus fmrfamide receptor 0.1205 0.2198 0.2233
Loa Loa (eye worm) HMP-2 protein 0.019 0.0323 0.0928
Loa Loa (eye worm) hypothetical protein 0.0026 0.002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0606 0.1092 0.3215
Brugia malayi prolyl oligopeptidase family protein 0.0127 0.0208 0.0197
Brugia malayi GCC2 and GCC3 family protein 0.0026 0.002 0.0009
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0014 0.001
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.1205 0.2198 0.2233
Schistosoma mansoni cathepsin D (A01 family) 0.0281 0.0491 0.145
Echinococcus multilocularis SWI:SNF matrix associated 0.0021 0.0011 0.0011
Brugia malayi GCC2 and GCC3 family protein 0.0026 0.002 0.0009
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0114 0.0183 1
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.0028 0.0024 0.0022
Schistosoma mansoni neuropeptide F-like receptor 0.1205 0.2198 0.6608
Echinococcus granulosus neuropeptide Y receptor 0.1205 0.2198 0.2233
Brugia malayi AKH receptor 0.1205 0.2198 0.2189
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0039 0.0044 0.0092
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0887 0.161 0.1601
Trypanosoma cruzi beta tubulin, putative 0.1557 0.2849 1
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0095 0.0148 0.0409
Onchocerca volvulus 0.1205 0.2198 0.8103
Brugia malayi neuropeptide F receptor 0.1205 0.2198 0.2189
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.1205 0.2198 0.6608
Schistosoma mansoni biogenic amine receptor 0.1205 0.2198 0.6608
Echinococcus granulosus neuropeptides capa receptor 0.1205 0.2198 0.2233
Toxoplasma gondii insulysin, putative 0.0023 0.0016 0.0055
Loa Loa (eye worm) TK/EPH protein kinase 0.0139 0.0229 0.0649
Loa Loa (eye worm) hypothetical protein 0.0042 0.005 0.0116
Echinococcus multilocularis insulin degrading enzyme 0.0025 0.0018 0.0018
Echinococcus multilocularis AMP deaminase 2 0.0028 0.0024 0.0025
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0025 0.0019 0.0025
Echinococcus granulosus biogenic amine 5HT receptor 0.1205 0.2198 0.2233
Leishmania major beta tubulin 0.1557 0.2849 1
Echinococcus multilocularis beta catenin 0.019 0.0323 0.0329
Echinococcus granulosus beta tubulin 0.1557 0.2849 0.2897
Brugia malayi PDZ domain containing protein 0.0026 0.002 0.0009
Echinococcus multilocularis neuropeptides capa receptor 0.1205 0.2198 0.2242
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Brugia malayi ephrin receptor 1 precursor 0.0052 0.0069 0.0058
Leishmania major beta tubulin 0.1557 0.2849 1
Trypanosoma brucei prolyl endopeptidase 0.0127 0.0208 0.067
Schistosoma mansoni CD36-like class B scavenger receptor 0.0042 0.005 0.0118
Loa Loa (eye worm) tubulin beta-4 chain 0.1557 0.2849 0.8438
Echinococcus multilocularis neuropeptides capa receptor 0.1205 0.2198 0.2242
Echinococcus multilocularis allatostatin A receptor 0.1482 0.271 0.2764
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0026 0.002 0.0033
Schistosoma mansoni opsin-like receptor 0.1205 0.2198 0.6608
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0025 0.0019 0.0008
Loa Loa (eye worm) hypothetical protein 0.1205 0.2198 0.6503
Toxoplasma gondii aspartyl protease ASP3 0.0023 0.0014 0.0049
Echinococcus multilocularis rhodopsin orphan GPCR 0.1205 0.2198 0.2242
Onchocerca volvulus 0.1205 0.2198 0.8103
Echinococcus granulosus g-protein coupled receptor 0.1205 0.2198 0.2233
Echinococcus granulosus neuropeptides capa receptor 0.1205 0.2198 0.2233

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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