Detailed information for compound 1610285

Basic information

Technical information
  • TDR Targets ID: 1610285
  • Name: 1,1-diketo-3,5-bis(4-nitrophenyl)-1,4-thiazin ane-2,6-dicarboxylic acid O2-ethyl O6-methyl ester
  • MW: 507.471 | Formula: C21H21N3O10S
  • H donors: 1 H acceptors: 8 LogP: 1.94 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOC(=O)C1C(NC(C(S1(=O)=O)C(=O)OC)c1ccc(cc1)[N+](=O)[O-])c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C21H21N3O10S/c1-3-34-21(26)19-17(13-6-10-15(11-7-13)24(29)30)22-16(18(20(25)33-2)35(19,31)32)12-4-8-14(9-5-12)23(27)28/h4-11,16-19,22H,3H2,1-2H3
  • InChiKey: FVPWVBLGYHLKEH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-Ethyl 6-methyl 3,5-bis(4-(hydroxy(oxido)amino)phenyl)-2,6-thiomorpholinedicarboxylate 1,1-dioxide
  • 3,5-bis(4-nitrophenyl)-1,1-dioxo-1,4-thiazinane-2,6-dicarboxylic acid O2-ethyl O6-methyl ester
  • 3,5-bis[4-(hydroxy-oxidoamino)phenyl]-1,1-dioxo-1,4-thiazinane-2,6-dicarboxylic acid O2-ethyl O6-methyl ester
  • 3,5-bis[4-(hydroxy-oxido-amino)phenyl]-1,1-diketo-1,4-thiazinane-2,6-dicarboxylic acid O2-ethyl O6-methyl ester
  • 4-[2-carbethoxy-6-carbomethoxy-5-[4-(hydroxy-oxido-ammonio)phenyl]-1,1-diketo-1,4-thiazinan-3-yl]-N-hydroxy-benzeneamine oxide
  • 4-[2-ethoxycarbonyl-5-[4-(hydroxy-oxidoazaniumyl)phenyl]-6-methoxycarbonyl-1,1-dioxo-1,4-thiazinan-3-yl]-N-hydroxybenzeneamine oxide
  • 4-[2-ethoxycarbonyl-5-[4-(hydroxy-oxido-ammonio)phenyl]-6-methoxycarbonyl-1,1-dioxo-1,4-thiazinan-3-yl]-N-hydroxy-benzeneamine oxide
  • 4-[2-ethoxycarbonyl-5-[4-(hydroxy-oxidoammonio)phenyl]-6-methoxycarbonyl-1,1-dioxo-1,4-thiazinan-3-yl]-N-hydroxybenzeneamine oxide
  • 4-[2-ethoxycarbonyl-5-[4-(hydroxy-oxido-azaniumyl)phenyl]-6-methoxycarbonyl-1,1-dioxo-1,4-thiazinan-3-yl]-N-hydroxy-benzeneamine oxide
  • AIDS-139872
  • AIDS139872
  • NCI60_017502
  • NSC650205
  • O2-ethyl O6-methyl 3,5-bis[4-(hydroxy-oxidoamino)phenyl]-1,1-dioxo-1,4-thiazinane-2,6-dicarboxylate
  • O2-ethyl O6-methyl 3,5-bis(4-nitrophenyl)-1,1-dioxo-1,4-thiazinane-2,6-dicarboxylate
  • O2-ethyl O6-methyl 3,5-bis[4-(hydroxy-oxido-amino)phenyl]-1,1-dioxo-1,4-thiazinane-2,6-dicarboxylate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0841 0.106
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0164 0.7209 0.7935
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0019 0.0213 0.0234
Echinococcus multilocularis neuropeptides capa receptor 0.014 0.6062 0.6672
Brugia malayi Protein kinase c protein 2 0.0048 0.1581 0.1581
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.014 0.6062 0.6672
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0841 0.106
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0022 0.0319 0.0319
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0022 0.0319 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.014 0.6062 0.6672
Schistosoma mansoni biogenic amine (dopamine) receptor 0.014 0.6062 0.7637
Schistosoma mansoni biogenic amine receptor 0.014 0.6062 0.7637
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0153 0.6686 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.014 0.6062 0.7637
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.0319 0.0477
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0022 0.0319 0.5
Brugia malayi larval opioid receptor 0.014 0.6062 0.6062
Schistosoma mansoni hypothetical protein 0.014 0.6062 0.7637
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.014 0.6062 0.6672
Brugia malayi hypothetical protein 0.014 0.6062 0.6062
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0841 0.106
Onchocerca volvulus 0.014 0.6062 1
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0022 0.0319 0.8264
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Brugia malayi G-protein coupled receptor 0.014 0.6062 0.6062
Mycobacterium ulcerans transmembrane transport protein 0.0022 0.0319 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.014 0.6062 0.6672
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.014 0.6062 0.6672
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.014 0.6062 0.6062
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.014 0.6062 0.7637
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0164 0.7209 0.7934
Loa Loa (eye worm) TYRA-2 protein 0.014 0.6062 0.6037
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Entamoeba histolytica protein kinase, putative 0.0019 0.0213 1
Schistosoma mansoni amine GPCR 0.014 0.6062 0.7637
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0022 0.0319 0.0319
Echinococcus multilocularis orexin receptor type 2 0.014 0.6062 0.6672
Echinococcus multilocularis protein kinase c epsilon type 0.0016 0.0063 0.0068
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0022 0.0346 0.0379
Leishmania major protein kinase, putative 0.0022 0.0346 0.4408
Echinococcus granulosus tm gpcr rhodopsin 0.014 0.6062 0.6672
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0022 0.0319 0.0402
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0164 0.7209 0.7191
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.0841 0.0926
Echinococcus granulosus cGMP dependent protein kinase 1 0.0022 0.0346 0.0381
Echinococcus multilocularis G-protein coupled receptor, putative 0.014 0.6062 0.6672
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.014 0.6062 0.6672
Echinococcus granulosus cGMP dependent protein kinase 1 0.0022 0.0346 0.0381
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0346 0.0436
Loa Loa (eye worm) G-protein coupled receptor 0.014 0.6062 0.6037
Brugia malayi Tachykinin-like peptides receptor 99D 0.014 0.6062 0.6062
Echinococcus granulosus sex peptide receptor 0.014 0.6062 0.6672
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0841 0.106
Echinococcus granulosus rhodopsin orphan GPCR 0.014 0.6062 0.6672
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Brugia malayi Dopamine receptor protein 1 0.014 0.6062 0.6062
Brugia malayi Dopamine receptor protein 2 0.014 0.6062 0.6062
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0186 0.0234
Brugia malayi hypothetical protein 0.014 0.6062 0.6062
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0022 0.0319 0.0351
Echinococcus granulosus biogenic amine 5HT receptor 0.014 0.6062 0.6672
Schistosoma mansoni neuropeptide receptor 0.014 0.6062 0.7637
Echinococcus granulosus neuropeptide Y receptor 0.014 0.6062 0.6672
Mycobacterium ulcerans transcriptional regulatory protein 0.0022 0.0319 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.014 0.6062 0.6672
Echinococcus granulosus tm gpcr rhodopsin 0.014 0.6062 0.6672
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.6062 0.7637
Echinococcus granulosus neuropeptide Y receptor 0.014 0.6062 0.6672
Schistosoma mansoni neuropeptide f receptor 76f 0.014 0.6062 0.7637
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.014 0.6062 0.7637
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0022 0.0346 0.0379
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0346 0.0436
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.6062 0.6672
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.0841 0.0926
Brugia malayi G-protein coupled receptor 0.014 0.6062 0.6062
Echinococcus multilocularis serotonin receptor 0.014 0.6062 0.6672
Echinococcus granulosus patatin phospholipase domain containing protein 0.0022 0.0319 0.0351
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0048 0.1571 0.1729
Loa Loa (eye worm) follicle stimulating hormone receptor 0.014 0.6062 0.6037
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0022 0.0319 0.0477
Echinococcus granulosus rhodopsin orphan GPCR 0.014 0.6062 0.6672
Trichomonas vaginalis STE family protein kinase 0.0019 0.0213 0.0318
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.6062 0.7637
Loa Loa (eye worm) hypothetical protein 0.0032 0.0841 0.0783
Schistosoma mansoni biogenic amine (5HT) receptor 0.014 0.6062 0.7637
Echinococcus granulosus rhodopsin orphan GPCR 0.014 0.6062 0.6672
Brugia malayi ORL1-like opioid receptor 0.014 0.6062 0.6062
Echinococcus multilocularis allatostatin A receptor 0.014 0.6062 0.6672
Loa Loa (eye worm) hypothetical protein 0.0142 0.616 0.6136
Echinococcus multilocularis g-protein coupled receptor 0.014 0.6062 0.6672
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.6062 0.7637
Echinococcus granulosus rhodopsin orphan GPCR 0.014 0.6062 0.6672
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.004 0.1197 0.1316
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Echinococcus multilocularis RNA directed DNA polymerase 0.004 0.1197 0.1316
Loa Loa (eye worm) neuropeptide F receptor 0.014 0.6062 0.6037
Trichomonas vaginalis STE family protein kinase 0.0019 0.0213 0.0318
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0164 0.7209 0.7209
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0019 0.0186 0.0204
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.1989 0.2506
Echinococcus granulosus somatostatin receptor 0.014 0.6062 0.6672
Echinococcus multilocularis tachykinin peptides receptor 99D 0.014 0.6062 0.6672
Schistosoma mansoni neuropeptide receptor 0.014 0.6062 0.7637
Echinococcus multilocularis fmrfamide receptor 0.014 0.6062 0.6672
Echinococcus granulosus neuropeptide s receptor 0.014 0.6062 0.6672
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.6062 0.7637
Mycobacterium tuberculosis Conserved protein 0.0022 0.0319 0.5
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0019 0.0213 0.0232
Schistosoma mansoni growth hormone secretagogue receptor 0.014 0.6062 0.7637
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.014 0.6062 0.6672
Onchocerca volvulus 0.014 0.6062 1
Echinococcus granulosus RNA directed DNA polymerase 0.004 0.1197 0.1318
Schistosoma mansoni amine GPCR 0.014 0.6062 0.7637
Echinococcus multilocularis neuropeptides capa receptor 0.014 0.6062 0.6672
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.6062 0.6672
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0319 0.0477
Echinococcus granulosus neuropeptide receptor 0.014 0.6062 0.6672
Onchocerca volvulus 0.014 0.6062 1
Schistosoma mansoni opsin-like receptor 0.014 0.6062 0.7637
Echinococcus multilocularis expressed conserved protein 0.0022 0.0346 0.0379
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.014 0.6062 0.6672
Onchocerca volvulus 0.014 0.6062 1
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0019 0.0213 0.0234
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.1571 0.1979
Loa Loa (eye worm) hypothetical protein 0.0019 0.0186 0.0123
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.014 0.6062 0.7637
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.1571 0.1979
Mycobacterium ulcerans hypothetical protein 0.0022 0.0319 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.014 0.6062 0.6672
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Echinococcus granulosus 7tm_1 domain containing protein 0.014 0.6062 0.6672
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.014 0.6062 0.6672
Brugia malayi P21-Rho-binding domain containing protein 0.0019 0.0186 0.0186
Schistosoma mansoni neuropeptide receptor 0.014 0.6062 0.7637
Brugia malayi Serotonin receptor 0.014 0.6062 0.6062
Echinococcus granulosus neuropeptide FF receptor 2 0.014 0.6062 0.6672
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0222 1 1
Echinococcus granulosus G protein coupled receptor 139 0.014 0.6062 0.6672
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0022 0.0319 0.0402
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0319 0.5
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0203 0.9085 1
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0032 0.0841 0.0924
Echinococcus granulosus allatostatin A receptor 0.014 0.6062 0.6672
Echinococcus granulosus orexin receptor type 2 0.014 0.6062 0.6672
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0019 0.0186 0.0203
Mycobacterium ulcerans hypothetical protein 0.0022 0.0319 0.5
Brugia malayi Dopamine receptor 0.014 0.6062 0.6062
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.0841 0.0924
Brugia malayi gonadotropin-releasing hormone receptor 2 0.014 0.6062 0.6062
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0022 0.0319 0.0349
Schistosoma mansoni protein kinase 0.0019 0.0213 0.0268
Onchocerca volvulus 0.014 0.6062 1
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Brugia malayi hypothetical protein 0.014 0.6062 0.6062
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Schistosoma mansoni neuropeptide F-like receptor 0.014 0.6062 0.7637
Echinococcus granulosus voltage gated potassium channel 0.0048 0.1571 0.1729
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.014 0.6062 0.6672
Echinococcus multilocularis neuropeptide s receptor 0.014 0.6062 0.6672
Echinococcus granulosus alpha 1A adrenergic receptor 0.014 0.6062 0.6672
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.014 0.6062 0.6672
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Echinococcus granulosus neuropeptide receptor A26 0.014 0.6062 0.6672
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Schistosoma mansoni neuropeptide F-like receptor 0.014 0.6062 0.7637
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.6062 0.7637
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.014 0.6062 0.6672
Brugia malayi G protein-coupled receptor F59B2.13 0.014 0.6062 0.6062
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.6062 0.6672
Brugia malayi AKH receptor 0.014 0.6062 0.6062
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.014 0.6062 0.7637
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0022 0.0319 0.0258
Schistosoma mansoni neuropeptide receptor 0.014 0.6062 0.7637
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.014 0.6062 0.6037
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0841 0.106
Loa Loa (eye worm) hypothetical protein 0.0048 0.1571 0.1517
Plasmodium falciparum cGMP-dependent protein kinase 0.0022 0.0346 1
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0032 0.0841 0.0924
Brugia malayi hypothetical protein 0.014 0.6062 0.6062
Echinococcus granulosus dro:myosuppressin receptor 0.014 0.6062 0.6672
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0022 0.0319 0.0402
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.6062 0.6672
Schistosoma mansoni amine GPCR 0.014 0.6062 0.7637
Echinococcus granulosus rhodopsin orphan GPCR 0.014 0.6062 0.6672
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.014 0.6062 0.7637
Echinococcus multilocularis PAK box P21 Rho binding 0.0019 0.0213 0.0232
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.0841 0.0783
Loa Loa (eye worm) hypothetical protein 0.0022 0.0319 0.0258
Echinococcus multilocularis neuropeptide receptor 0.014 0.6062 0.6672
Onchocerca volvulus 0.014 0.6062 1
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0022 0.0319 0.0402
Brugia malayi hypothetical protein 0.014 0.6062 0.6062
Echinococcus granulosus peptide allatostatin:somatostatin 0.014 0.6062 0.6672
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Brugia malayi protein kinase C II. 0.0016 0.0063 0.0063
Echinococcus multilocularis g protein coupled receptor 0.014 0.6062 0.6672
Echinococcus granulosus fmrfamide receptor 0.014 0.6062 0.6672
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.6062 0.7637
Schistosoma mansoni hypothetical protein 0.014 0.6062 0.7637
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0022 0.0319 0.0402
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Onchocerca volvulus 0.014 0.6062 1
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0022 0.0319 0.0477
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.014 0.6062 0.7637
Brugia malayi WH1 domain containing protein 0.0019 0.0186 0.0186
Brugia malayi Melatonin receptor type 1A 0.014 0.6062 0.6062
Onchocerca volvulus 0.014 0.6062 1
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Loa Loa (eye worm) hypothetical protein 0.004 0.1197 0.1141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.6062 0.7637
Schistosoma mansoni myosin xvIII 0.014 0.6062 0.7637
Echinococcus granulosus Protein kinase C brain isozyme 0.0056 0.1989 0.219
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0022 0.0319 0.0402
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0022 0.0319 0.0349
Echinococcus multilocularis sex peptide receptor 0.014 0.6062 0.6672
Echinococcus multilocularis serotonin receptor 0.014 0.6062 0.6672
Echinococcus multilocularis g protein coupled receptor 0.014 0.6062 0.6672
Schistosoma mansoni voltage-gated potassium channel 0.0179 0.7938 1
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0022 0.0319 0.5
Schistosoma mansoni protein kinase 0.0019 0.0186 0.0234
Treponema pallidum catabolite gene activator (Crp) 0.0022 0.0319 0.5
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0319 0.5
Entamoeba histolytica protein kinase, putative 0.0019 0.0213 1
Entamoeba histolytica protein kinase, putative 0.0019 0.0213 1
Echinococcus multilocularis neuropeptide receptor 0.014 0.6062 0.6672
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0022 0.0319 0.8264
Trypanosoma brucei protein kinase A regulatory subunit 0.0022 0.0319 0.8264
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.6062 0.6672
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0022 0.0319 0.0319
Schistosoma mansoni biogenic amine (dopamine) receptor 0.014 0.6062 0.7637
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0063 0.0079
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Mycobacterium ulcerans hypothetical protein 0.0022 0.0319 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.014 0.6062 0.6062
Brugia malayi putative neuropeptide receptor 0.014 0.6062 0.6062
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.6062 0.7637
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0032 0.0841 0.0924
Entamoeba histolytica protein kinase, putative 0.0019 0.0213 1
Brugia malayi hypothetical protein 0.014 0.6062 0.6062
Echinococcus granulosus cGMP dependent protein kinase 0.0022 0.0346 0.0381
Schistosoma mansoni biogenic amine (5HT) receptor 0.014 0.6062 0.7637
Schistosoma mansoni hypothetical protein 0.0019 0.0186 0.0234
Onchocerca volvulus 0.014 0.6062 1
Brugia malayi Protein kinase domain 0.0019 0.0213 0.0213
Echinococcus granulosus thyrotropin releasing hormone receptor 0.014 0.6062 0.6672
Brugia malayi follicle stimulating hormone receptor 0.014 0.6062 0.6062
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0032 0.0841 0.0926
Mycobacterium ulcerans hypothetical protein 0.0022 0.0319 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.014 0.6062 0.6672
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0022 0.0319 0.0349
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Brugia malayi hypothetical protein 0.014 0.6062 0.6062
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0032 0.0841 0.0926
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0048 0.1571 0.1571
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.0841 0.1258
Schistosoma mansoni tyrosine kinase 0.0019 0.0186 0.0234
Echinococcus multilocularis voltage gated potassium channel 0.0048 0.1571 0.1727
Brugia malayi hypothetical protein 0.014 0.6062 0.6062
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0019 0.0213 0.0232
Echinococcus multilocularis PAK box P21 Rho binding 0.0019 0.0186 0.0203
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0022 0.0319 0.0349
Schistosoma mansoni peptide (allatostatin)-like receptor 0.014 0.6062 0.7637
Trypanosoma cruzi cAMP binding protein, putative 0.0023 0.038 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.014 0.6062 0.6037
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0346 0.0436
Loa Loa (eye worm) melatonin receptor type 1A 0.014 0.6062 0.6037
Echinococcus granulosus g protein coupled receptor 0.014 0.6062 0.6672
Onchocerca volvulus 0.014 0.6062 1
Echinococcus multilocularis G protein coupled receptor 139 0.014 0.6062 0.6672
Schistosoma mansoni hypothetical protein 0.014 0.6062 0.7637
Loa Loa (eye worm) hypothetical protein 0.0046 0.1492 0.1438
Echinococcus multilocularis fmrfamide receptor 0.014 0.6062 0.6672
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.014 0.6062 0.6672
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0022 0.0319 0.0349
Echinococcus multilocularis neuropeptide Y receptor 0.014 0.6062 0.6672
Onchocerca volvulus 0.014 0.6062 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0319 0.0258
Schistosoma mansoni hypothetical protein 0.0019 0.0186 0.0234
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.014 0.6062 0.7637
Brugia malayi P21-Rho-binding domain containing protein 0.0019 0.0186 0.0186
Brugia malayi RE15519p 0.014 0.6062 0.6062
Schistosoma mansoni biogenic amine receptor 0.014 0.6062 0.7637
Schistosoma mansoni biogenic amine (dopamine) receptor 0.014 0.6062 0.7637
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0022 0.0346 1
Loa Loa (eye worm) neuropeptide F receptor 0.014 0.6062 0.6037
Mycobacterium ulcerans regulatory protein 0.0022 0.0319 0.5
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Loa Loa (eye worm) AGC/PKG protein kinase 0.0022 0.0346 0.0285
Schistosoma mansoni protein kinase 0.0019 0.0213 0.0268
Echinococcus granulosus neuropeptide receptor 0.014 0.6062 0.6672
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0022 0.0319 0.0351
Brugia malayi N-terminal motif family protein 0.0022 0.0319 0.0319
Treponema pallidum cyclic nucleotide binding protein 0.0022 0.0319 0.5
Entamoeba histolytica p21-activated kinase 0.0019 0.0213 1
Echinococcus granulosus g protein coupled receptor 0.014 0.6062 0.6672
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.6062 0.7637
Schistosoma mansoni protein kinase 0.0019 0.0213 0.0268
Echinococcus granulosus protein kinase c iota type 0.0015 0.0002 0.0002
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0022 0.0319 0.0477
Echinococcus granulosus g protein coupled receptor 0.014 0.6062 0.6672
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0153 0.6686 1
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Schistosoma mansoni opsin-like receptor 0.014 0.6062 0.7637
Onchocerca volvulus 0.014 0.6062 1
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.1989 0.2506
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Echinococcus granulosus serotonin receptor 0.014 0.6062 0.6672
Onchocerca volvulus 0.014 0.6062 1
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0022 0.0319 0.5
Treponema pallidum catabolite gene activator 0.0022 0.0319 0.5
Trypanosoma brucei Flagellar Member 6 0.0022 0.0319 0.8264
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.014 0.6062 0.6037
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0019 0.0213 0.0234
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0022 0.0319 0.0402
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.0841 0.0926
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0022 0.0319 0.0402
Echinococcus granulosus g-protein coupled receptor 0.014 0.6062 0.6672
Echinococcus granulosus protein kinase c epsilon type 0.0016 0.0063 0.0069
Brugia malayi hypothetical protein 0.014 0.6062 0.6062
Trichomonas vaginalis STE family protein kinase 0.0019 0.0213 0.0318
Schistosoma mansoni hypothetical protein 0.0019 0.0186 0.0234
Brugia malayi GnHR receptor homolog 0.014 0.6062 0.6062
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0203 0.9085 1
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0019 0.0186 0.0123
Trypanosoma brucei cAMP binding protein, putative 0.0023 0.038 1
Schistosoma mansoni voltage-gated potassium channel 0.0179 0.7938 1
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.014 0.6062 0.6672
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Echinococcus multilocularis serine threonine protein kinase 0.005 0.1694 0.1863
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.0841 0.0783
Onchocerca volvulus 0.014 0.6062 1
Schistosoma mansoni hypothetical protein 0.014 0.6062 0.7637
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.014 0.6062 0.6672
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0022 0.0319 0.0402
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Leishmania major hypothetical protein, conserved 0.0023 0.038 1
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Brugia malayi G protein-coupled receptor 0.014 0.6062 0.6062
Echinococcus multilocularis neuropeptide receptor A26 0.014 0.6062 0.6672
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0022 0.0319 1
Schistosoma mansoni amine GPCR 0.014 0.6062 0.7637
Brugia malayi hypothetical protein 0.014 0.6062 0.6062
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0048 0.1571 0.1727
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Brugia malayi neuropeptide F receptor 0.014 0.6062 0.6062
Echinococcus multilocularis neuropeptide FF receptor 2 0.014 0.6062 0.6672
Trichomonas vaginalis STE family protein kinase 0.0019 0.0213 0.0318
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.0841 0.1258
Echinococcus granulosus neuropeptides capa receptor 0.014 0.6062 0.6672
Schistosoma mansoni histamine h1 receptor 0.014 0.6062 0.7637
Trichomonas vaginalis STE family protein kinase 0.0019 0.0213 0.0318
Echinococcus multilocularis g protein coupled receptor 0.014 0.6062 0.6672
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.014 0.6062 0.6672
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0056 0.1989 0.2188
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Schistosoma mansoni hypothetical protein 0.0022 0.0319 0.0402
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0841 0.106
Echinococcus multilocularis somatostatin receptor 0.014 0.6062 0.6672
Echinococcus granulosus protein kinase C gamma type 0.005 0.1694 0.1865
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.6062 0.6672
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0022 0.0319 0.0349
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Schistosoma mansoni biogenic amine receptor 0.014 0.6062 0.7637
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.014 0.6062 0.7637
Echinococcus granulosus 7TM GPCR rhodopsin 0.014 0.6062 0.6672
Echinococcus granulosus tm gpcr rhodopsin 0.014 0.6062 0.6672
Echinococcus multilocularis dro:myosuppressin receptor 0.014 0.6062 0.6672
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0022 0.0319 0.5
Onchocerca volvulus 0.014 0.6062 1
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0522 0.0658
Brugia malayi Serotonin/octopamine receptor family protein 7 0.014 0.6062 0.6062
Onchocerca volvulus 0.014 0.6062 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.014 0.6062 0.6672
Echinococcus multilocularis neuropeptide Y receptor 0.014 0.6062 0.6672
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0022 0.0319 0.0351
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0019 0.0213 0.0232
Schistosoma mansoni atypical protein kinase C 0.0015 0.0002 0.0002
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.0841 0.0926
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0022 0.0319 0.0402
Mycobacterium leprae Conserved hypothetical protein 0.0022 0.0319 1
Treponema pallidum cyclic nucleotide binding protein 0.0022 0.0319 0.5
Brugia malayi sulfakinin receptor protein 0.014 0.6062 0.6062
Brugia malayi Cyclic-nucleotide gated cation channel 0.0032 0.0841 0.0841
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Onchocerca volvulus 0.014 0.6062 1
Brugia malayi Egg laying defective protein 4 0.0022 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.014 0.6062 0.6037
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0022 0.0319 0.5
Schistosoma mansoni opsin-like receptor 0.014 0.6062 0.7637
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0022 0.0319 0.0402
Echinococcus granulosus PAK box P21 Rho binding 0.0019 0.0186 0.0204
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0042 0.1286 0.123
Brugia malayi Serotonin receptor 0.014 0.6062 0.6062
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0019 0.0186 0.0234
Leishmania major protein kinase, putative 0.0022 0.0346 0.4408
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0186 0.0278
Onchocerca volvulus Neuropeptide F receptor homolog 0.014 0.6062 1
Echinococcus granulosus neuropeptides capa receptor 0.014 0.6062 0.6672
Loa Loa (eye worm) G-protein coupled receptor 0.014 0.6062 0.6037
Echinococcus granulosus hypothetical protein 0.014 0.6062 0.6672
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.0841 0.0924
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.6062 0.6672
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.014 0.6062 0.7637
Echinococcus granulosus biogenic amine 5HT receptor 0.014 0.6062 0.6672
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0019 0.0186 0.0204
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0022 0.0319 0.0402
Brugia malayi putative neuropeptide receptor NPR1 0.014 0.6062 0.6062
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.014 0.6062 1
Schistosoma mansoni 60S ribosomal protein L21 0.0026 0.0522 0.0658
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.014 0.6062 0.6037
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.014 0.6062 0.6062
Echinococcus granulosus rhodopsin orphan GPCR 0.014 0.6062 0.6672
Schistosoma mansoni adenoreceptor 0.014 0.6062 0.7637
Trypanosoma brucei cAMP response protein 1, putative 0.0022 0.0319 0.8264
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0022 0.0319 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.6062 0.6672
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0022 0.0319 0.0351
Schistosoma mansoni amine GPCR 0.014 0.6062 0.7637
Brugia malayi neuropeptide F receptor 0.014 0.6062 0.6062

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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