Detailed information for compound 161603

Basic information

Technical information
  • TDR Targets ID: 161603
  • Name: (2R,3R,4S,5R)-2-(4-amino-5-chloropyrrolo[2,3- d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3, 4-diol
  • MW: 300.698 | Formula: C11H13ClN4O4
  • H donors: 4 H acceptors: 5 LogP: -0.72 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cc(c2c1ncnc2N)Cl
  • InChi: 1S/C11H13ClN4O4/c12-4-1-16(10-6(4)9(13)14-3-15-10)11-8(19)7(18)5(2-17)20-11/h1,3,5,7-8,11,17-19H,2H2,(H2,13,14,15)/t5-,7-,8-,11-/m1/s1
  • InChiKey: WUHZZVWKGCJQHU-IOSLPCCCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2R,3R,4S,5R)-2-(4-amino-5-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-(4-amino-5-chloro-7-pyrrolo[2,3-d]pyrimidinyl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-(4-azanyl-5-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol
  • (2R,3R,4S,5R)-2-(4-amino-5-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-5-methylol-tetrahydrofuran-3,4-diol
  • 5-chlorotubercidin
  • (2R,3R,4S,5R)-2-(4-amino-5-chloropyrrolo[3,2-e]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol
  • (2R,3R,4S,5R)-2-(4-amino-5-chloro-pyrrolo[3,2-e]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-(4-amino-5-chloro-7-pyrrolo[3,2-e]pyrimidinyl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-(4-amino-5-chloro-pyrrolo[3,2-e]pyrimidin-7-yl)-5-methylol-tetrahydrofuran-3,4-diol
  • (2R,3R,4S,5R)-2-(4-amino-5-chloro-pyrrolo[3,2-e]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-3,4-diol
  • 2-(4-Amino-5-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol
  • AIDS-187689
  • AIDS187689
  • 7H-Pyrrolo(2,3-d)pyrimidin-4-amine, 5-chloro-7-beta-D-ribofuranosyl-
  • NSC 124149

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Onchocerca volvulus Get druggable targets OG5_128398 All targets in OG5_128398
Schistosoma japonicum ko:K00856 adenosine kinase [EC2.7.1.20], putative Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania infantum adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania donovani adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma congolense adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Schistosoma mansoni adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Echinococcus multilocularis adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Cryptosporidium parvum adenosine kinase like ribokinase Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei gambiense adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Schistosoma mansoni adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania major adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Brugia malayi Adenosine kinase-like Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania braziliensis adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Candida albicans adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei gambiense adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Neospora caninum GG10762, related Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma cruzi adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Candida albicans putative adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Toxoplasma gondii kinase, pfkB family protein Get druggable targets OG5_128398 All targets in OG5_128398
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128398 All targets in OG5_128398
Echinococcus granulosus adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Babesia bovis adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania mexicana adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi adenosine kinase, putative adenosine kinase 345 aa 337 aa 35.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Treponema pallidum flavodoxin 0.0188 0.197 1
Echinococcus multilocularis solute carrier family 22 0.0029 0.0145 0.016
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0188 0.197 0.1922
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0492 0.546 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2209 0.3981
Loa Loa (eye worm) hypothetical protein 0.003 0.0149 0.0167
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0145 0.0266
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0145 0.016
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0552 0.0914
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Plasmodium falciparum calcium-dependent protein kinase 5 0.0064 0.0543 0.0488
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0056 0.045 0.0725
Leishmania major cytochrome P450 reductase, putative 0.0436 0.4817 0.881
Mycobacterium tuberculosis Probable monooxygenase 0.0056 0.045 1
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0145 0.016
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0344 0.0522
Echinococcus granulosus GPCR family 2 0.0032 0.017 0.0206
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Brugia malayi Adenosine kinase-like 0.0105 0.1015 0.186
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0188 0.197 0.3538
Loa Loa (eye worm) hypothetical protein 0.01 0.0953 0.1656
Loa Loa (eye worm) hypothetical protein 0.0026 0.0106 0.0087
Giardia lamblia Hypothetical protein 0.0436 0.4817 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2209 0.3981
Echinococcus multilocularis geminin 0.0174 0.1812 0.3247
Echinococcus multilocularis adenosine kinase 0.0105 0.1015 0.1772
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Echinococcus granulosus geminin 0.0174 0.1812 0.3247
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0056 0.045 0.0725
Loa Loa (eye worm) FAD binding domain-containing protein 0.0304 0.3298 0.5997
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0492 0.546 0.5433
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Trypanosoma cruzi adenosine kinase, putative 0.0105 0.1015 0.1772
Echinococcus multilocularis solute carrier family 22 0.0029 0.0145 0.016
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0378 0.0693
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0543 0.0897
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0145 0.0154
Entamoeba histolytica protein kinase, putative 0.0064 0.0543 0.2534
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.0056 0.045 0.0394
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Trypanosoma brucei adenosine kinase, putative 0.0105 0.1015 0.1772
Plasmodium vivax proline--tRNA ligase, putative 0.0073 0.0647 0.0592
Schistosoma mansoni hypothetical protein 0.0032 0.017 0.0206
Brugia malayi RNA, U transporter 1 0.0084 0.0778 0.1424
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0064 0.0543 0.0488
Schistosoma mansoni NADPH flavin oxidoreductase 0.0248 0.2655 0.4807
Schistosoma mansoni cytochrome P450 reductase 0.0492 0.546 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0149 0.0167
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0492 0.546 1
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0344 0.087
Entamoeba histolytica hypothetical protein 0.0047 0.0344 0.1491
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.017 0.0206
Echinococcus granulosus solute carrier family 22 0.0029 0.0145 0.016
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0056 0.045 0.0725
Trypanosoma brucei glucose transporter, putative 0.0065 0.0552 0.0914
Schistosoma mansoni sugar transporter 0.0029 0.0145 0.016
Schistosoma mansoni glucose transport protein 0.0209 0.2209 0.3981
Brugia malayi major facilitator superfamily protein 0.0029 0.0145 0.0266
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Schistosoma mansoni hypothetical protein 0.0174 0.1812 0.3247
Echinococcus granulosus solute carrier family 22 0.0029 0.0145 0.016
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0209 0.2209 0.3981
Trypanosoma brucei nitrate reductase, putative 0.0056 0.045 0.0725
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0063 0.0528 0.0869
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0552 0.0914
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0492 0.546 1
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0552 0.0914
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Trypanosoma cruzi p450 reductase, putative 0.0056 0.045 0.0725
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0552 0.0914
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0647 0.109
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0188 0.197 0.3538
Loa Loa (eye worm) hypothetical protein 0.0047 0.0344 0.0528
Schistosoma mansoni sugar transporter 0.0029 0.0145 0.016
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0552 0.0914
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0056 0.045 0.0725
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0106 0.0087
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0145 0.016
Schistosoma mansoni importin beta-1 0.003 0.0149 0.0167
Brugia malayi Sugar transporter family protein 0.0209 0.2209 0.4046
Trichomonas vaginalis sulfite reductase, putative 0.0492 0.546 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.2209 0.3981
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0084 0.0047
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0304 0.3298 0.5997
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0492 0.546 1
Toxoplasma gondii protein kinase, putative 0.059 0.6593 1
Brugia malayi Importin beta-1 subunit 0.003 0.0149 0.0272
Echinococcus multilocularis methionine synthase reductase 0.0304 0.3298 0.5997
Entamoeba histolytica hypothetical protein 0.0024 0.0084 0.0134
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.2605 0.4715
Giardia lamblia Prolyl-tRNA synthetase 0.0063 0.0528 0.0986
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Echinococcus multilocularis calcium dependent protein kinase 0.006 0.0497 0.0812
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0492 0.546 1
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0492 0.546 1
Schistosoma mansoni glucose transport protein 0.0209 0.2209 0.3981
Schistosoma mansoni hypothetical protein 0.0317 0.3449 0.6278
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.017 0.0206
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0338 0.3688 0.5555
Loa Loa (eye worm) hypothetical protein 0.0063 0.0528 0.0869
Schistosoma mansoni hypothetical protein 0.0032 0.017 0.0206
Leishmania major hypothetical protein, conserved 0.0029 0.0145 0.016
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Trypanosoma cruzi reductase, putative 0.0056 0.045 0.0725
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0145 0.016
Giardia lamblia Nitric oxide synthase, inducible 0.0436 0.4817 1
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0552 0.0914
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0059 0.0107
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0056 0.045 0.0725
Leishmania major NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Plasmodium falciparum calcium-dependent protein kinase 1 0.0064 0.0543 0.0488
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0145 0.016
Plasmodium falciparum importin beta, putative 0.003 0.0149 0.0091
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0056 0.045 0.0725
Loa Loa (eye worm) sugar transporter 0.0209 0.2209 0.3981
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Schistosoma mansoni adenosine kinase 0.0105 0.1015 0.1772
Trypanosoma cruzi p450 reductase, putative 0.0492 0.546 1
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0145 0.0133
Leishmania major nitrate reductase, putative 0.0056 0.045 0.0725
Toxoplasma gondii sugar transporter ST2 0.0029 0.0145 0.0133
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0344 0.0528
Schistosoma mansoni protein kinase 0.0064 0.0543 0.0897
Leishmania major cytochrome-b5 reductase, putative 0.0056 0.045 0.0725
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0492 0.546 1
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0188 0.197 0.3538
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0188 0.197 0.1922
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0145 0.016
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0064 0.0543 0.0897
Leishmania major hypothetical protein, conserved 0.0026 0.0106 0.0087
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0063 0.0528 0.0967
Trypanosoma brucei glucose transporter, putative 0.0065 0.0552 0.0914
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0552 0.0914
Echinococcus multilocularis cytochrome b5 reductase 4 0.0056 0.045 0.0725
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0344 0.0629
Toxoplasma gondii kinase, pfkB family protein 0.0105 0.1015 0.1464
Trypanosoma brucei adenosine kinase, putative 0.0105 0.1015 0.1772
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Onchocerca volvulus 0.0056 0.045 0.4162
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0145 0.0266
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0063 0.0528 1
Leishmania major oxidoreductase-like protein 0.0056 0.045 0.0725
Brugia malayi FAD binding domain containing protein 0.0304 0.3298 0.604
Loa Loa (eye worm) hypothetical protein 0.0064 0.0543 0.0897
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0145 0.016
Plasmodium vivax hexose transporter 0.0209 0.2209 0.2163
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0056 0.045 0.0725
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0552 0.0914
Schistosoma mansoni hypothetical protein 0.0032 0.017 0.0206
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0149 0.0138
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Mycobacterium ulcerans oxidoreductase 0.0056 0.045 0.0719
Loa Loa (eye worm) hypothetical protein 0.0105 0.1015 0.1772
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.017 0.0206
Trypanosoma brucei glucose transporter 1E 0.0065 0.0552 0.0914
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0263 0.3856
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0647 0.109
Trypanosoma brucei glucose transporter, putative 0.0065 0.0552 0.0914
Schistosoma mansoni glucose transporter 0.0029 0.0145 0.016
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Plasmodium vivax importin-beta 2, putative 0.003 0.0149 0.0091
Schistosoma mansoni adenosine kinase 0.0105 0.1015 0.1772
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0103 0.0083
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0344 0.0528
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0064 0.0543 0.0897
Schistosoma mansoni hypothetical protein 0.0174 0.1812 0.3247
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0145 0.016
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Echinococcus granulosus adenosine kinase 0.0105 0.1015 0.1772
Leishmania major glucose transporter, lmgt2 0.0065 0.0552 0.0914
Toxoplasma gondii flavodoxin domain-containing protein 0.0244 0.2612 0.3908
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0543 0.0897
Loa Loa (eye worm) hypothetical protein 0.0243 0.2605 0.4715
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0263 0.3856
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0953 0.1746
Chlamydia trachomatis sulfite reductase 0.0304 0.3298 1
Brugia malayi FAD binding domain containing protein 0.0492 0.546 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Plasmodium falciparum NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0394
Schistosoma mansoni protein kinase 0.0064 0.0543 0.0897
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0064 0.0543 0.0897
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.0056 0.045 0.0599
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0188 0.197 0.3538
Trypanosoma brucei glucose transporter 2A 0.0065 0.0552 0.0914
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0552 0.0914
Chlamydia trachomatis Na(+)-translocating NADH-quinone reductase subunit F 0.0056 0.045 0.1199
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0084 0.0047
Mycobacterium tuberculosis Possible oxygenase 0.0056 0.045 1
Leishmania major NADH-dependent fumarate reductase, putative 0.0056 0.045 0.0725
Brugia malayi hypothetical protein 0.0243 0.2605 0.4772
Trypanosoma brucei glucose transporter, putative 0.0065 0.0552 0.0914
Leishmania major NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Plasmodium falciparum ferredoxin--NADP reductase 0.0056 0.045 0.0394
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0064 0.0543 0.0897
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0056 0.045 0.0725
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0344 0.0528
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0344 0.0287
Leishmania major cytochrome-b5 reductase, putative 0.0056 0.045 0.0725
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.2605 0.4715
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0543 0.0897
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0106 0.0087
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0056 0.045 0.0725
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0436 0.4817 0.881
Mycobacterium ulcerans electron transfer protein FdxB 0.0056 0.045 0.0719
Schistosoma mansoni cytochrome B5 0.0056 0.045 0.0725
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0149 0.0167
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0647 0.109
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0344 0.0528
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0084 0.0047
Loa Loa (eye worm) hypothetical protein 0.0032 0.017 0.0206
Giardia lamblia Sugar-proton symporter 0.0029 0.0145 0.0182
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0591 0.1082
Schistosoma mansoni hypothetical protein 0.0209 0.2209 0.3981
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0063 0.0528 0.0967
Schistosoma mansoni glucose transport protein 0.0209 0.2209 0.3981
Onchocerca volvulus 0.0093 0.0878 1
Trypanosoma brucei NADH-dependent fumarate reductase 0.0056 0.045 0.0725
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Schistosoma mansoni sugar transporter 0.0029 0.0145 0.016
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Trypanosoma brucei oxidoreductase-protein, putative 0.0056 0.045 0.0725
Echinococcus granulosus importin subunit beta 1 0.003 0.0149 0.0167
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0063 0.0528 0.0869
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0543 0.0897
Echinococcus multilocularis snurportin 1 0.0317 0.3449 0.6278
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0647 0.109
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0543 0.0897
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Brugia malayi hypothetical protein 0.0029 0.0145 0.0266
Plasmodium vivax calcium-dependent protein kinase, putative 0.0064 0.0543 0.0488
Mycobacterium tuberculosis Probable oxidoreductase 0.0056 0.045 1
Trypanosoma cruzi oxidoreductase-protein, putative 0.0056 0.045 0.0725
Schistosoma mansoni survival motor neuron protein 0.005 0.0378 0.0592
Plasmodium vivax flavodoxin domain containing protein 0.0436 0.4817 0.4787
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0188 0.197 0.3538
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Plasmodium vivax sugar transporter, putative 0.0029 0.0145 0.0087
Echinococcus multilocularis importin subunit beta 1 0.003 0.0149 0.0167
Trypanosoma brucei sugar transporter, putative 0.0029 0.0145 0.016
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0145 0.5
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0073 0.0647 0.0901
Loa Loa (eye worm) hypothetical protein 0.0068 0.0591 0.0985
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0344 0.0522
Plasmodium falciparum mitogen-activated protein kinase 2 0.0338 0.3688 0.3651
Leishmania major glucose transporter, lmgt1 0.0065 0.0552 0.0914
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.2209 0.3981
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0338 0.3688 0.3651
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0552 0.0914
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Plasmodium falciparum nitric oxide synthase, putative 0.0492 0.546 0.5433
Loa Loa (eye worm) sugar transporter 0.0029 0.0145 0.016
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0056 0.045 0.0725
Mycobacterium ulcerans oxygenase 0.0056 0.045 0.0719
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0188 0.197 0.3538
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0145 0.016
Trypanosoma cruzi nitrate reductase, putative 0.0056 0.045 0.0725
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Onchocerca volvulus 0.005 0.0378 0.318
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0145 0.016
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2209 0.3981
Entamoeba histolytica protein kinase, putative 0.0064 0.0543 0.2534
Leishmania major glucose transporter, lmgt3 0.0065 0.0552 0.0914
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0056 0.045 1
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0056 0.045 1
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0188 0.197 0.3538
Echinococcus granulosus snurportin 1 0.0317 0.3449 0.6278
Toxoplasma gondii flavodoxin domain-containing protein 0.0244 0.2612 0.3908
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0492 0.546 1
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0145 0.016
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.017 0.0206
Mycobacterium ulcerans sugar transporter 0.0029 0.0145 0.0154
Entamoeba histolytica type A flavoprotein, putative 0.0188 0.197 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0145 0.016
Leishmania major protein kinase, putative 0.0064 0.0543 0.0897
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0056 0.045 0.0725
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0056 0.045 0.0824
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Trypanosoma brucei glucose transporter, putative 0.0065 0.0552 0.0914
Brugia malayi Cam kinase protein 1 0.0064 0.0543 0.0994
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 0.3449 0.6278
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0106 0.0047
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Plasmodium falciparum protein kinase 7 0.059 0.6593 0.6572
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Brugia malayi flavodoxin family protein 0.0188 0.197 0.3607
Plasmodium vivax ferredoxin--NADP reductase, putative 0.0056 0.045 0.0394
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0064 0.0543 0.0994
Brugia malayi flavodoxin family protein 0.0492 0.546 1
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.2209 0.3981
Echinococcus granulosus neuropeptide receptor A26 0.0449 0.4963 0.908
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0344 0.3046
Echinococcus granulosus General substrate transporter 0.018 0.1871 0.3356
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0064 0.0543 0.0742
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0492 0.546 1
Schistosoma mansoni protein kinase 0.0064 0.0543 0.0897
Brugia malayi Latrophilin receptor protein 2 0.0032 0.017 0.0311
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0552 0.0914
Loa Loa (eye worm) FAD binding domain-containing protein 0.0492 0.546 1
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0344 0.0436
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0145 0.016
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0145 0.016
Treponema pallidum ferredoxin-NADP(+) reductase subunit alpha 0.0056 0.045 0.2034
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0647 0.109
Trypanosoma brucei glucose transporter, putative 0.0065 0.0552 0.0914
Trypanosoma brucei glucose transporter, putative 0.0065 0.0552 0.0914
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0344 0.0287
Toxoplasma gondii sugar transporter ST3 0.0029 0.0145 0.0133
Mycobacterium ulcerans monooxygenase 0.0056 0.045 0.0719
Giardia lamblia Hexose transporter 0.0029 0.0145 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0145 0.016
Trypanosoma brucei glucose transporter, putative 0.0065 0.0552 0.0914
Brugia malayi major facilitator superfamily protein 0.0029 0.0145 0.0266
Mycobacterium ulcerans flavodoxin oxidoreductase 0.0056 0.045 0.0719
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0492 0.546 1
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0145 0.016
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0344 0.0528
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0953 0.1746
Loa Loa (eye worm) flavodoxin family protein 0.0188 0.197 0.3538
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0145 0.016
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Plasmodium falciparum proline--tRNA ligase 0.0073 0.0647 0.0592
Toxoplasma gondii facilitative glucose transporter GT1 0.0209 0.2209 0.3291
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0063 0.0528 0.0869
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0064 0.0543 0.0742
Echinococcus granulosus cytochrome b5 reductase 4 0.0056 0.045 0.0725
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0344 0.0528
Plasmodium falciparum calcium-dependent protein kinase 3 0.0064 0.0543 0.0488
Echinococcus granulosus methionine synthase reductase 0.0304 0.3298 0.5997
Schistosoma mansoni diflavin oxidoreductase 0.0244 0.2612 0.4728
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0543 0.0897
Trypanosoma cruzi hexose transporter 0.0065 0.0552 0.0914
Plasmodium falciparum hexose transporter 0.0209 0.2209 0.2163
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0528 0.0869
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0344 0.0528
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.017 0.0311
Echinococcus multilocularis solute carrier family 22 0.0029 0.0145 0.016
Trypanosoma brucei NADH-dependent fumarate reductase 0.0056 0.045 0.0725
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0953 0.1656
Loa Loa (eye worm) hypothetical protein 0.0063 0.0528 0.0869
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0106 0.0047
Brugia malayi hypothetical protein 0.0029 0.0145 0.0266
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0552 0.0914
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0145 0.0087
Brugia malayi hypothetical protein 0.0029 0.0145 0.0266
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0106 0.0047
Entamoeba histolytica type A flavoprotein, putative 0.0188 0.197 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0064 0.0543 0.0742
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0543 0.0897
Brugia malayi hypothetical protein 0.0026 0.0106 0.0194
Leishmania major NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Schistosoma mansoni hypothetical protein 0.005 0.0378 0.0592
Echinococcus multilocularis neuropeptide receptor A26 0.0449 0.4963 0.908
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0056 0.045 0.0725
Entamoeba histolytica type A flavoprotein, putative 0.0188 0.197 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0528 0.0869
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0145 0.0154
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Echinococcus multilocularis neuropeptide s receptor 0.0449 0.4963 0.908
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.0552 0.0914
Echinococcus multilocularis General substrate transporter 0.018 0.1871 0.3356
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0056 0.045 0.0725
Trypanosoma cruzi adenosine kinase, putative 0.0105 0.1015 0.1772
Leishmania major hypothetical protein, conserved 0.0188 0.197 0.3538
Entamoeba histolytica type A flavoprotein, putative 0.0188 0.197 1
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0344 0.0599
Plasmodium falciparum calcium-dependent protein kinase 4 0.0064 0.0543 0.0488
Echinococcus granulosus solute carrier family 22 0.0029 0.0145 0.016
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0064 0.0543 0.0488
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0277 0.0405
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0215 0.0289
Plasmodium vivax hypothetical protein, conserved 0.0188 0.197 0.1922
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0145 0.016
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0188 0.197 0.3538
Loa Loa (eye worm) hypothetical protein 0.0051 0.0393 0.0619
Entamoeba histolytica type A flavoprotein, putative 0.0188 0.197 1
Echinococcus granulosus solute carrier family 22 0.0029 0.0145 0.016
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.2209 0.3981
Brugia malayi diaphorase 0.0056 0.045 0.0824
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0543 0.0897
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.017 0.0206
Echinococcus multilocularis GPCR, family 2 0.0032 0.017 0.0206
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0492 0.546 1
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.0056 0.045 0.0599
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0145 0.0266
Leishmania major NADH-dependent fumarate reductase-like protein 0.0056 0.045 0.0725
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0145 0.0154
Giardia lamblia Flavohemoprotein lateral transfer candidate 0.0056 0.045 0.0823
Echinococcus multilocularis solute carrier family 22 0.0029 0.0145 0.016
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0064 0.0543 0.0488
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0543 0.0897
Schistosoma mansoni hypothetical protein 0.0032 0.017 0.0206
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0145 0.016
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0063 0.0528 0.2456
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Leishmania major importin beta-1 subunit, putative 0.0024 0.0084 0.0047
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0056 0.045 0.0725
Loa Loa (eye worm) hypothetical protein 0.0492 0.546 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0106 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0552 0.0914
Brugia malayi Sugar transporter family protein 0.0029 0.0145 0.0266
Loa Loa (eye worm) hypothetical protein 0.0029 0.0145 0.016
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0492 0.546 1
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0106 0.0072
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0056 0.045 0.0725
Trypanosoma brucei NADH-cytochrome b5 reductase-like protein 0.0056 0.045 0.0725
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0145 0.016
Echinococcus granulosus cytochrome b5 reductase 4 0.0056 0.045 0.0725
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Brugia malayi Sugar transporter family protein 0.0029 0.0145 0.0266
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0084 0.0047
Leishmania major adenosine kinase, putative 0.0105 0.1015 0.1772
Schistosoma mansoni hypothetical protein 0.0068 0.0591 0.0985
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0344 0.0528
Leishmania major reductase, putative 0.0056 0.045 0.0725
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0492 0.546 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0145 0.016
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0056 0.045 0.0725
Mycobacterium ulcerans flavodoxin reductase Hmp 0.0056 0.045 0.0719
Echinococcus granulosus neuropeptide s receptor 0.0449 0.4963 0.908
Loa Loa (eye worm) diaphorase 0.0056 0.045 0.0725
Toxoplasma gondii sugar transporter ST1 0.0029 0.0145 0.0133
Plasmodium vivax CDK-related protein kinase 6, putative 0.0887 1 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0064 0.0543 0.0488
Leishmania major p450 reductase, putative 0.0492 0.546 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.2209 0.3981
Echinococcus granulosus calcium dependent protein kinase 0.006 0.0497 0.0812
Schistosoma mansoni sugar transporter 0.0029 0.0145 0.016

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.678 Inhibition concentration against human adenosine kinase ChEMBL. 11958989
IC50 (binding) = 0.68 Concentration required for 50% inhibition of the adenosine kinase (AK) activity. ChEMBL. 15149648
IC50 (binding) = 0.21 uM Inhibition of human adenosine kinase activity ChEMBL. 11958989
IC50 (binding) = 0.21 uM Inhibition of recombinant human adenosine kinase ChEMBL. 10956196
IC50 (binding) = 0.21 uM Inhibition of human adenosine kinase activity ChEMBL. 11958989
IC50 (binding) = 0.21 uM Inhibition of recombinant human adenosine kinase ChEMBL. 10956196
IC50 (functional) = 10 uM Cytotoxicity against uninfected human foreskin fibroblast(HFF cells) ChEMBL. 2846837
ID50 (functional) = 0.014 ug ml-1 Dose required to inhibit proliferation of L-1210 Cells by 50% ChEMBL. 6699874
Log IC50 (binding) = 0.6778 Inhibition concentration against human adenosine kinase ChEMBL. 11958989
log(10'3/IC50) (binding) = 3.68 Inhibition of adenosine kinase ChEMBL. 18359230
logIC50 (binding) = -0.6778 Inhibition of adenosine kinase (unknown origin) ChEMBL. No reference
MCC (functional) = 4 ug ml-1 Concentration required to cause a microscopically detectable alteration in cell morphology in HeLa cell cultures. ChEMBL. 6699874

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 2846837

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

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