Detailed information for compound 1627791

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1765.56 | Formula: C44H68O55S9
  • H donors: 11 H acceptors: 31 LogP: -9.15 Rotable bonds: 41
    Rule of 5 violations (Lipinski): 4
  • SMILES: CO[C@@H]1[C@@H](OC)[C@H](O[C@@H]2[C@@H](COS(=O)(=O)O)O[C@H]([C@@H]([C@H]2OS(=O)(=O)O)OS(=O)(=O)O)O[C@@H]2[C@@H](O[C@H]([C@@H]([C@H]2OCCCc2ccccc2)OS(=O)(=O)O)O[C@@H]2[C@@H](COS(=O)(=O)O)O[C@@H]([C@@H]([C@H]2OS(=O)(=O)O)OS(=O)(=O)O)OC)C(=O)O)O[C@@H]([C@H]1O[C@@H]1O[C@H](COS(=O)(=O)O)[C@H]([C@@H]([C@H]1OS(=O)(=O)O)OC)OC)C(=O)O
  • InChi: 1S/C44H68O55S9/c1-76-21-18(14-82-100(49,50)51)86-42(34(24(21)77-2)96-105(64,65)66)90-27-25(78-3)33(79-4)41(92-31(27)38(45)46)88-23-20(16-84-102(55,56)57)87-43(37(99-108(73,74)75)30(23)95-104(61,62)63)91-28-26(81-13-9-12-17-10-7-6-8-11-17)35(97-106(67,68)69)44(93-32(28)39(47)48)89-22-19(15-83-101(52,53)54)85-40(80-5)36(98-107(70,71)72)29(22)94-103(58,59)60/h6-8,10-11,18-37,40-44H,9,12-16H2,1-5H3,(H,45,46)(H,47,48)(H,49,50,51)(H,52,53,54)(H,55,56,57)(H,58,59,60)(H,61,62,63)(H,64,65,66)(H,67,68,69)(H,70,71,72)(H,73,74,75)/t18-,19-,20-,21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32-,33-,34-,35-,36-,37-,40+,41-,42+,43+,44-/m1/s1
  • InChiKey: DSUUEYJVCLKSCO-GRHHQPMUSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0085 0.0493 0.0376
Plasmodium falciparum acyl carrier protein 0.0056 0.0207 0.2016
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0448 0.4047 0.518
Mycobacterium ulcerans polyketide synthase Pks9 0.0368 0.3265 0.4179
Onchocerca volvulus Huntingtin homolog 0.0127 0.0905 0.0811
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0033 0.0106
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0591 0.5452 0.6897
Schistosoma mansoni hypothetical protein 0.0042 0.0071 0.0254
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.0217 0.0013
Onchocerca volvulus 0.0976 0.9226 0.9713
Loa Loa (eye worm) hypothetical protein 0.0936 0.8834 1
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0191 0.1532 0.1742
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.014 0.1025 0.1312
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0033 0.0319
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0033 0.0252
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0033 0.0106
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0056 0.0207 0.2016
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.0217 0.0013
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0556 0.5113 0.5113
Plasmodium vivax acyl carrier protein, putative 0.0056 0.0207 0.2016
Loa Loa (eye worm) hypothetical protein 0.0127 0.0905 0.1025
Brugia malayi hypothetical protein 0.0246 0.2068 0.2068
Mycobacterium ulcerans Type I modular polyketide synthase 0.0556 0.5113 0.6545
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0527 0.4826 0.5463
Echinococcus multilocularis snurportin 1 0.032 0.2796 0.3526
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0448 0.4047 0.518
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.025 0.2436
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0306 0.2987
Schistosoma mansoni hypothetical protein 0.0037 0.0023 0.0081
Toxoplasma gondii type I fatty acid synthase, putative 0.0396 0.354 0.6482
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0063 0.0278 0.0093
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0063 0.0278 0.0356
Mycobacterium tuberculosis Conserved protein 0.0168 0.13 0.1437
Mycobacterium ulcerans polyketide synthase 0.0556 0.5113 0.6545
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.014 0.1025 1
Trichomonas vaginalis conserved hypothetical protein 0.0168 0.13 1
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0023 0.0081
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.014 0.1025 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0033 0.0037
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0085 0.0493 0.0376
Onchocerca volvulus 0.0527 0.4826 0.5005
Onchocerca volvulus Huntingtin homolog 0.0127 0.0905 0.0811
Mycobacterium ulcerans fatty acid synthase Fas 0.0175 0.137 0.1753
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0306 0.2987
Toxoplasma gondii type I fatty acid synthase 0.0085 0.0493 0.0902
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0033 0.0033
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0086 0.0109
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0591 0.5452 0.6979
Brugia malayi Methyltransferase-like protein 4 0.0168 0.13 0.13
Plasmodium vivax hypothetical protein, conserved 0.008 0.0438 0.4269
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0832 0.7812 1
Leishmania major cathepsin L-like protease 0.0066 0.0306 0.2357
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0033 0.0117
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0306 0.2987
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0306 0.2987
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0175 0.137 0.1529
Leishmania major acyl carrier protein, putative 0.0056 0.0207 0.1591
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0225 0.1862 0.2177
Mycobacterium ulcerans hypothetical protein 0.0056 0.0207 0.0265
Loa Loa (eye worm) hypothetical protein 0.0051 0.016 0.0181
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.014 0.1025 0.1025
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0843 0.7927 1
Onchocerca volvulus 0.0063 0.0278 0.0139
Mycobacterium leprae Probable polyketide synthase Pks1 0.0591 0.5452 0.6897
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.014 0.1025 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0556 0.5113 0.6451
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0063 0.0278 0.0093
Loa Loa (eye worm) hypothetical protein 0.0044 0.0086 0.0098
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.2068 0.2608
Loa Loa (eye worm) hypothetical protein 0.0085 0.0493 0.0558
Schistosoma mansoni hypothetical protein 0.032 0.2796 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0556 0.5113 0.6451
Echinococcus multilocularis protein dispatched 1 0.005 0.0147 0.0186
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0123 0.0859 0.1083
Schistosoma mansoni hypothetical protein 0.0042 0.0071 0.0254
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0063 0.0278 0.0356
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0063 0.0278 0.0093
Echinococcus granulosus tumor protein p63 0.0351 0.3102 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0123 0.0859 0.2768
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0175 0.137 0.1529
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0056 0.0207 0.0063
Echinococcus multilocularis Niemann Pick C1 protein 0.0146 0.1091 0.1376
Leishmania major hypothetical protein, conserved 0.0168 0.13 1
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0056 0.0207 0.2016
Brugia malayi AMP-binding enzyme family protein 0.0527 0.4826 0.4826
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.014 0.1025 0.1161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0306 0.2987
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0136 0.0989 0.1028
Schistosoma mansoni hypothetical protein 0.0176 0.1384 0.4951
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0306 0.2987
Loa Loa (eye worm) hypothetical protein 0.0102 0.066 0.0747
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.04 0.3576 0.443
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0306 0.2987
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.066 1
Schistosoma mansoni hypothetical protein 0.0042 0.0071 0.0254
Mycobacterium ulcerans acyl carrier protein 0.0056 0.0207 0.0265
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.0675 0.2416
Echinococcus granulosus AMP dependent ligase 0.0057 0.0217 0.0698
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.014 0.1025 0.3668
Echinococcus multilocularis geminin 0.0176 0.1384 0.1746
Loa Loa (eye worm) hypothetical protein 0.0085 0.0493 0.0558
Mycobacterium ulcerans Type I modular polyketide synthase 0.0556 0.5113 0.6545
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0063 0.0278 0.0093
Schistosoma mansoni hypothetical protein 0.0176 0.1384 0.4951
Brugia malayi hypothetical protein 0.0127 0.0905 0.0905
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.008 0.0438 0.4269
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0306 0.2987
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0023 0.0028
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0171 0.1333 0.1481
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0057 0.0217 0.0277
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.066 0.066
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.066 0.2127
Loa Loa (eye worm) hypothetical protein 0.0246 0.2068 0.2341
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.014 0.1025 0.1293
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0306 0.2987
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0368 0.3265 0.4179
Toxoplasma gondii acyl carrier protein ACP 0.0056 0.0207 0.0379
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.014 0.1025 1
Echinococcus granulosus acyl carrier protein mitochondrial 0.0056 0.0207 0.0666
Schistosoma mansoni lipoxygenase 0.0086 0.0497 0.1776
Schistosoma mansoni lipoxygenase 0.0123 0.0859 0.3071
Mycobacterium ulcerans acyl carrier protein 0.0056 0.0207 0.0265
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0033 0.0041
Mycobacterium ulcerans polyketide synthase MbtD 0.0171 0.1333 0.1707
Schistosoma mansoni hypothetical protein 0.0056 0.0207 0.074
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0539 0.4946 0.6231
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0086 0.0098
Echinococcus multilocularis protein patched 0.0044 0.0086 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0306 0.2987
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0591 0.5452 0.6897
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0033 0.0319
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0033 0.0319
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0148 0.0148
Schistosoma mansoni survival motor neuron protein 0.005 0.0148 0.0528
Onchocerca volvulus 0.0051 0.016 0.0013
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0033 0.0041
Echinococcus multilocularis NADH dehydrogenase 0.0056 0.0207 0.0261
Brugia malayi Phosphopantetheine attachment site family protein 0.0056 0.0207 0.0207
Loa Loa (eye worm) acyl carrier protein 0.0256 0.2165 0.2451
Schistosoma mansoni patched 1 0.0044 0.0086 0.0309
Loa Loa (eye worm) acyl carrier protein 0.0056 0.0207 0.0234
Brugia malayi AMP-binding enzyme family protein 0.0172 0.1343 0.1343
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.014 0.1025 0.3305
Schistosoma mansoni hypothetical protein 0.005 0.0148 0.0528
Schistosoma mansoni methyltransferase-related 0.0168 0.13 0.4649
Echinococcus multilocularis expressed conserved protein 0.0096 0.0599 0.0755
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0086 0.0424
Mycobacterium ulcerans Type I modular polyketide synthase 0.0556 0.5113 0.6545
Leishmania major cathepsin L-like protease 0.0066 0.0306 0.2357
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0306 0.2987
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0056 0.0207 0.0207
Brugia malayi RNA, U transporter 1 0.0085 0.0492 0.0492
Mycobacterium ulcerans polyketide synthase 0.0591 0.5452 0.6979
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0591 0.5452 0.6897
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.014 0.1025 1
Mycobacterium ulcerans thioesterase 0.0464 0.4203 0.538
Entamoeba histolytica acyl-CoA synthetase, putative 0.0057 0.0217 0.3046
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0023 0.0073
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0056 0.0207 0.0261
Mycobacterium ulcerans polyketide synthase MbtC 0.014 0.1025 0.1312
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0556 0.5113 0.6451
Mycobacterium leprae Polyketide synthase Pks13 0.0832 0.7812 1
Giardia lamblia Methyltransferase like 2 0.0168 0.13 1
Onchocerca volvulus Fatty acid synthase homolog 0.1003 0.9494 1
Brugia malayi CHE-14 protein 0.0044 0.0086 0.0086
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0057 0.0217 0.0277
Echinococcus granulosus expressed conserved protein 0.0096 0.0599 0.1931
Schistosoma mansoni acyl carrier protein 0.0056 0.0207 0.074
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0056 0.0207 0.2016
Entamoeba histolytica acyl-CoA synthetase, putative 0.0081 0.0449 0.6686
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0368 0.3265 0.402
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0033 0.016
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0085 0.0493 0.0376
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0033 0.0041
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.014 0.1025 0.1877
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0539 0.4946 0.6231
Echinococcus granulosus geminin 0.0176 0.1384 0.4461
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0464 0.4203 0.5255
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.066 0.0832
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0063 0.0278 0.0093
Schistosoma mansoni hypothetical protein 0.0042 0.0071 0.0254
Chlamydia trachomatis acyl carrier protein 0.0056 0.0207 0.2016
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0063 0.0278 0.0356
Mycobacterium tuberculosis Hypothetical protein 0.0168 0.13 0.1437
Loa Loa (eye worm) fatty acid synthase 0.0549 0.504 0.5706
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0086 0.0279
Toxoplasma gondii type I fatty acid synthase, putative 0.0592 0.5462 1
Mycobacterium ulcerans polyketide synthase Pks13 0.0832 0.7812 1
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.016 0.0572
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.014 0.1025 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0033 0.0117
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0361 0.3196 0.5851
Echinococcus multilocularis tumor protein p63 0.0351 0.3102 0.3913
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0527 0.4826 0.6073
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0086 0.0279
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0085 0.0493 0.0376
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.032 0.2796 0.3165
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0316 0.2758 0.3355
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0591 0.5452 0.6979
Echinococcus granulosus Niemann Pick C1 protein 0.0146 0.1091 0.3516
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0167 0.1629
Mycobacterium ulcerans acyl-CoA synthetase 0.0063 0.0278 0.0356
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0063 0.0278 0.0278
Echinococcus granulosus snurportin 1 0.032 0.2796 0.9011
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0063 0.0278 0.0356
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0056 0.0207 0.0234
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0282 0.2424 0.4437
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0306 0.2987
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0085 0.0493 0.0376
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0556 0.5113 0.6545
Mycobacterium ulcerans thioesterase TesA 0.0464 0.4203 0.538
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.014 0.1025 0.789
Loa Loa (eye worm) hypothetical protein 0.0312 0.2713 0.3071
Mycobacterium tuberculosis Probable thioesterase TesA 0.0464 0.4203 0.5255
Leishmania major cathepsin L-like protease 0.0066 0.0306 0.2357
Echinococcus multilocularis AMP dependent ligase 0.0057 0.0217 0.0273
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0448 0.4047 0.5049
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0455 0.4119 0.5143
Treponema pallidum acyl carrier protein 0.0056 0.0207 0.5
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0832 0.7812 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0306 0.2987
Loa Loa (eye worm) hypothetical protein 0.0127 0.0905 0.1025
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.014 0.1025 1
Echinococcus granulosus NADH dehydrogenase 0.0056 0.0207 0.0666
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.2068 0.6665
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0556 0.5113 0.6451
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0306 0.2987
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0033 0.0106
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0591 0.5452 0.6897
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0591 0.5452 0.6897
Loa Loa (eye worm) hypothetical protein 0.0054 0.0183 0.0208
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.014 0.1025 0.1312
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0306 0.2987
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0556 0.5113 0.6451
Brugia malayi hypothetical protein 0.0037 0.0023 0.0023

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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