TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 297.352 | Formula: C17H19N3O2
H donors: 1 H acceptors: 1 LogP: 2.19 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: NCCCCn1c2cc3OCOc3cc2c2c1c(C)ncc2
InChi: 1S/C17H19N3O2/c1-11-17-12(4-6-19-11)13-8-15-16(22-10-21-15)9-14(13)20(17)7-3-2-5-18/h4,6,8-9H,2-3,5,7,10,18H2,1H3
InChiKey: LGWCTYRTABVWOH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	Starlite/ChEMBL	References
Homo sapiens	germ cell associated 2 (haspin)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Serine/threonine-protein kinase haspin, putative	Get druggable targets OG5_130553	All targets in OG5_130553
Leishmania infantum	protein kinase, putative,dual-specificity protein kinase, putative	Get druggable targets OG5_127439	All targets in OG5_127439
Toxoplasma gondii	cell-cycle-associated protein kinase DYRK2, putative	Get druggable targets OG5_127439	All targets in OG5_127439
Schistosoma japonicum	ko:K08286 protein-serine/threonine kinase [EC2.7.11.-], putative	Get druggable targets OG5_130553	All targets in OG5_130553
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_127439	All targets in OG5_127439
Echinococcus multilocularis	serine:threonine protein kinase haspin	Get druggable targets OG5_130553	All targets in OG5_130553
Echinococcus multilocularis	serine:threonine protein kinase haspin	Get druggable targets OG5_130553	All targets in OG5_130553
Loa Loa (eye worm)	haspin protein kinase	Get druggable targets OG5_130553	All targets in OG5_130553
Loa Loa (eye worm)	haspin protein kinase	Get druggable targets OG5_130553	All targets in OG5_130553
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_130553	All targets in OG5_130553
Neospora caninum	hypothetical protein	Get druggable targets OG5_127439	All targets in OG5_127439
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_127439	All targets in OG5_127439
Trypanosoma congolense	dual-specificity protein kinase, putative	Get druggable targets OG5_127439	All targets in OG5_127439
Echinococcus granulosus	dual specificity	Get druggable targets OG5_127439	All targets in OG5_127439
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_127439	All targets in OG5_127439
Giardia lamblia	Kinase, CMGC DYRK	Get druggable targets OG5_127439	All targets in OG5_127439
Echinococcus granulosus	dual specificity	Get druggable targets OG5_127439	All targets in OG5_127439
Leishmania mexicana	protein kinase, putative,dual-specificity protein kinase, putative	Get druggable targets OG5_127439	All targets in OG5_127439
Leishmania braziliensis	protein kinase, putative,dual-specificity protein kinase, putative	Get druggable targets OG5_127439	All targets in OG5_127439
Trypanosoma brucei	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	Get druggable targets OG5_127439	All targets in OG5_127439
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_127439	All targets in OG5_127439
Trypanosoma cruzi	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	Get druggable targets OG5_127439	All targets in OG5_127439
Echinococcus granulosus	serine:threonine protein kinase haspin	Get druggable targets OG5_130553	All targets in OG5_130553
Brugia malayi	GSG2	Get druggable targets OG5_130553	All targets in OG5_130553
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127439	All targets in OG5_127439
Brugia malayi	hypothetical protein	Get druggable targets OG5_130553	All targets in OG5_130553
Echinococcus granulosus	serine:threonine protein kinase haspin	Get druggable targets OG5_130553	All targets in OG5_130553
Echinococcus granulosus	dual specificity	Get druggable targets OG5_127439	All targets in OG5_127439
Brugia malayi	Dual-specificity tyrosine-phosphorylation regulated kinase 2	Get druggable targets OG5_127439	All targets in OG5_127439
Echinococcus granulosus	serine:threonine protein kinase haspin	Get druggable targets OG5_130553	All targets in OG5_130553
Echinococcus multilocularis	dual specificity	Get druggable targets OG5_127439	All targets in OG5_127439
Echinococcus multilocularis	dual specificity	Get druggable targets OG5_127439	All targets in OG5_127439
Leishmania major	protein kinase, putative,dual-specificity protein kinase, putative	Get druggable targets OG5_127439	All targets in OG5_127439
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_127439	All targets in OG5_127439
Loa Loa (eye worm)	CMGC/DYRK/DYRK2 protein kinase	Get druggable targets OG5_127439	All targets in OG5_127439
Echinococcus multilocularis	dual specificity	Get druggable targets OG5_127439	All targets in OG5_127439
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_127439	All targets in OG5_127439
Candida albicans	weaker similarity to S. cerevisiae YAK1 (YJL141C)	Get druggable targets OG5_127439	All targets in OG5_127439
Candida albicans	weaker similarity to S. cerevisiae YAK1 (YJL141C)	Get druggable targets OG5_127439	All targets in OG5_127439
Leishmania mexicana	protein kinase-like protein	Get druggable targets OG5_127439	All targets in OG5_127439
Loa Loa (eye worm)	haspin protein kinase	Get druggable targets OG5_130553	All targets in OG5_130553
Schistosoma japonicum	ko:K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase, putative	Get druggable targets OG5_127439	All targets in OG5_127439
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127439	All targets in OG5_127439
Trypanosoma brucei gambiense	protein kinase, putative,dual-specificity protein kinase, putative	Get druggable targets OG5_127439	All targets in OG5_127439
Leishmania donovani	dual-specificity protein kinase, putative	Get druggable targets OG5_127439	All targets in OG5_127439
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127439	All targets in OG5_127439

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	target of rapamycin (TOR), putative	0.2942	0.7428	1
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0255	0.061	0.061
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.0125	0.0125
Leishmania major	phosphatidylinositol kinase, putative	0.0255	0.061	0.061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2942	0.7428	0.7428
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0255	0.061	0.061
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0047	0.0047
Onchocerca volvulus		0.0255	0.061	0.5
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0255	0.061	0.061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2942	0.7428	0.7428
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0255	0.061	0.061
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0255	0.061	0.061
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0255	0.061	0.061
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0073	0.0147	0.0147
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.0015	0.0015
Echinococcus multilocularis	serine:threonine protein kinase haspin	0.0082	0.0171	0.0171
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0255	0.061	0.061
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0108	0.0236	0.0236
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0255	0.061	0.0769
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.0108	0.0236	0.3871
Loa Loa (eye worm)	phosphatidylinositol 3	0.3956	1	1
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0834	0.2077	0.2756
Echinococcus multilocularis	dual specificity	0.0064	0.0125	0.0125
Echinococcus granulosus	serine/threonine protein kinase	0.0023	0.002	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.0834	0.2077	0.2077
Schistosoma mansoni	hypothetical protein	0.0578	0.143	0.143
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0255	0.061	0.061
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0255	0.061	0.061
Entamoeba histolytica	hypothetical protein	0.0255	0.061	0.061
Schistosoma mansoni	hypothetical protein	0.0255	0.061	0.061
Echinococcus multilocularis	serine protein kinase ATM	0.0748	0.186	0.186
Loa Loa (eye worm)	FKBP5 protein	0.0108	0.0236	0.0236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3956	1	1
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0255	0.061	0.061
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0578	0.143	0.143
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0255	0.061	0.061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2654	0.6695	0.6695
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2942	0.7428	0.7428
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0108	0.0236	0.0236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0748	0.186	0.186
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0108	0.0236	0.0236
Loa Loa (eye worm)	phosphatidylinositol 3	0.0255	0.061	0.061
Loa Loa (eye worm)	haspin protein kinase	0.0083	0.0173	0.0173
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0255	0.061	0.061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2942	0.7428	0.7428
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0748	0.186	0.186
Entamoeba histolytica	protein kinase 2, putative	0.0021	0.0015	0.0015
Entamoeba histolytica	hypothetical protein	0.0255	0.061	0.061
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0255	0.061	0.061
Echinococcus multilocularis	voltage gated potassium channel	0.0021	0.0015	0.0015
Loa Loa (eye worm)	phosphatidylinositol 3	0.1327	0.3328	0.3328
Giardia lamblia	Kinase, AGC PKA	0.0021	0.0015	0.0015
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0748	0.186	0.186
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2133	0.5374	0.5374
Leishmania major	hypothetical protein, conserved	0.0255	0.061	0.061
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0023	0.002	0.002
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0255	0.061	0.061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2136	0.5382	0.5382
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0255	0.061	0.061
Trypanosoma cruzi	Protein kinase B	0.0023	0.002	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3147	0.7946	0.7946
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0108	0.0236	0.0236
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0108	0.0236	0.0236
Giardia lamblia	Hypothetical protein	0.0255	0.061	0.061
Brugia malayi	FAT domain containing protein	0.0578	0.143	0.143
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0748	0.186	0.186
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.002	0.0013	0.0013
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0255	0.061	0.061
Schistosoma mansoni	serine/threonine-protein kinase	0.0023	0.002	0.002
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0082	0.0171	0.0171
Loa Loa (eye worm)	haspin protein kinase	0.0082	0.0171	0.0171
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0255	0.061	1
Echinococcus granulosus	dual specificity	0.0064	0.0125	0.0125
Echinococcus multilocularis	fk506 binding protein	0.0108	0.0236	0.0236
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0047	0.0047
Echinococcus multilocularis	nervana 2	0.002	0.0013	0.0013
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0255	0.061	0.061
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0255	0.061	0.061
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0031	0.0041	0.0041
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2568	0.6478	0.6478
Schistosoma mansoni	immunophilin	0.0093	0.0198	0.0198
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0108	0.0236	0.0236
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0255	0.061	0.061
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0255	0.061	0.061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1327	0.3328	0.3328
Brugia malayi	Dual-specificity tyrosine-phosphorylation regulated kinase 2	0.0064	0.0125	0.0125
Echinococcus multilocularis	Glutaredoxin protein 5	0.002	0.0013	0.0013
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.1327	0.3328	0.3328
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0255	0.061	0.061
Loa Loa (eye worm)	haspin protein kinase	0.0082	0.0171	0.0171
Entamoeba histolytica	protein kinase, putative	0.0064	0.0125	0.0125
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.3956	1	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.3956	1	1
Schistosoma mansoni	hypothetical protein	0.0082	0.0171	0.0171
Echinococcus multilocularis	dual specificity	0.0064	0.0125	0.0125
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0255	0.061	0.061
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.1871	0.4709	0.4709
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3147	0.7946	0.7946
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0082	0.0171	0.0171
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0255	0.061	0.061
Schistosoma mansoni	voltage-gated potassium channel	0.0079	0.0164	0.0164
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0255	0.061	1
Toxoplasma gondii	FATC domain-containing protein	0.0748	0.186	0.2463
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0255	0.061	0.061
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.3956	1	1
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0255	0.061	0.061
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0255	0.061	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0255	0.061	0.061
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.1327	0.3328	0.3328
Loa Loa (eye worm)	CMGC/DYRK/DYRK2 protein kinase	0.0064	0.0125	0.0125
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0255	0.061	0.061
Trypanosoma cruzi	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.0064	0.0125	0.0125
Entamoeba histolytica	hypothetical protein	0.0748	0.186	0.186
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2136	0.5382	0.5382
Echinococcus multilocularis		0.0255	0.061	0.061
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0748	0.186	0.186
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0255	0.061	0.061
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0748	0.186	0.186
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0255	0.061	0.061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3147	0.7946	0.7946
Echinococcus granulosus	dual specificity	0.0064	0.0125	0.0125
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0255	0.061	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0255	0.061	0.061
Schistosoma mansoni	immunophilin	0.0108	0.0236	0.0236
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0255	0.061	0.061
Echinococcus granulosus	dual specificity	0.0064	0.0125	0.0125
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0255	0.061	0.061
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0108	0.0236	0.5
Echinococcus multilocularis	rac serine:threonine kinase	0.0023	0.002	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0255	0.061	0.061
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0068	0.0134	0.0134
Echinococcus multilocularis	nervana 2	0.002	0.0013	0.0013
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.315	0.7954	0.7954
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0255	0.061	0.061
Brugia malayi	p70 ribosomal S6 kinase beta	0.0031	0.0041	0.0041
Trichomonas vaginalis	CMGC family protein kinase	0.0064	0.0125	0.0125
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.3956	1	1
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0255	0.061	0.061
Entamoeba histolytica	protein kinase, putative	0.0031	0.0041	0.0041
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0108	0.0236	0.0236
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0108	0.0236	0.0236
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.1327	0.3328	0.3328
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2364	0.596	0.596
Echinococcus multilocularis	Zinc finger, PHD finger	0.0255	0.061	0.061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3956	1	1
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0255	0.061	0.061
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.1327	0.3328	0.3328
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3147	0.7946	0.7946
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0255	0.061	0.0769
Loa Loa (eye worm)	phosphatidylinositol 3	0.0255	0.061	0.061
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1327	0.3328	0.3328
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0108	0.0236	0.0236
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0073	0.0147	0.0147
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0255	0.061	0.061
Toxoplasma gondii	cell-cycle-associated protein kinase DYRK2, putative	0.0064	0.0125	0.0114
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.1327	0.3328	0.3328
Plasmodium vivax	hypothetical protein, conserved	0.0255	0.061	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2364	0.596	0.596
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2133	0.5374	0.5374
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0021	0.0015	0.0015
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0021	0.0015	0.0015
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0021	0.0015	0.0249
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.3956	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0255	0.061	0.061
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0255	0.061	0.061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1327	0.3328	0.3328
Loa Loa (eye worm)	phosphatidylinositol 3	0.0255	0.061	0.061
Loa Loa (eye worm)	hypothetical protein	0.0748	0.186	0.186
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0748	0.186	0.186
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0255	0.061	0.061
Loa Loa (eye worm)	hypothetical protein	0.0493	0.1213	0.1213
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0093	0.0198	0.0198
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0108	0.0236	0.0236
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0021	0.0015	0.0015
Trypanosoma cruzi	target of rapamycin kinase 3	0.315	0.7954	0.7954
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.3956	1	1
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0108	0.0236	0.0236
Schistosoma mansoni	voltage-gated potassium channel	0.0021	0.0015	0.0015
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0021	0.0015	0.0249
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0255	0.061	0.061
Schistosoma mansoni	voltage-gated potassium channel	0.0079	0.0164	0.0164
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0255	0.061	1
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0255	0.061	0.061
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0255	0.061	0.0769
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.3956	1	1
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0033	0.0047	0.0047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2942	0.7428	0.7428
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0255	0.061	0.061
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.315	0.7954	0.7954
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0108	0.0236	0.0236
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0255	0.061	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0748	0.186	0.186
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0073	0.0147	0.0147
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0068	0.0134	0.0134
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0047	0.0047
Leishmania major	fk506-binding protein 1-like protein	0.0108	0.0236	0.0236
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0255	0.061	0.061
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0108	0.0236	0.3871
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0255	0.061	0.061
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0015	0.0015
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.0108	0.0236	0.0236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0255	0.061	0.061
Trichomonas vaginalis	CMGC family protein kinase	0.0064	0.0125	0.0125
Echinococcus granulosus	nervana 2	0.002	0.0013	0.0013
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0023	0.002	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1327	0.3328	0.3328
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0255	0.061	0.061
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0255	0.061	0.061
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0748	0.186	0.186
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0255	0.061	0.061
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.3956	1	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0255	0.061	0.061
Trichomonas vaginalis	CMGC family protein kinase	0.0064	0.0125	0.0125
Trichomonas vaginalis	CMGC family protein kinase	0.0064	0.0125	0.0125
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0255	0.061	0.061
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.1643	0.4131	0.4131
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0255	0.061	0.061
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0255	0.061	0.061
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1327	0.3328	0.3328
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0073	0.0147	0.0147
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0255	0.061	0.5
Giardia lamblia	Kinase, CMGC DYRK	0.0064	0.0125	0.0125
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.3956	1	1
Trichomonas vaginalis	CMGC family protein kinase	0.0064	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0255	0.061	0.061
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0493	0.1213	0.1213
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.002	0.0013	0.0013
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3956	1	1
Leishmania major	phosphatidylinositol 3-kinase, putative	0.1327	0.3328	0.3328
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0198	0.0198
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0047	0.0047
Loa Loa (eye worm)	phosphatidylinositol 3	0.0255	0.061	0.061
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.0026	0.0026
Echinococcus granulosus	Glutaredoxin protein 5	0.002	0.0013	0.0013
Entamoeba histolytica	protein kinase, putative	0.0033	0.0047	0.0047
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0108	0.0236	0.0236
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0021	0.0015	0.0015
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0255	0.061	0.061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1061	0.2655	0.2655
Entamoeba histolytica	protein kinase, putative	0.0033	0.0047	0.0047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.234	0.59	0.59
Echinococcus granulosus	nervana 2	0.002	0.0013	0.0013
Echinococcus multilocularis	dual specificity	0.0064	0.0125	0.0125
Trichomonas vaginalis	fk506-binding protein, putative	0.0108	0.0236	0.0236
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0255	0.061	0.061
Loa Loa (eye worm)	hypothetical protein	0.0806	0.2007	0.2007
Brugia malayi	GSG2	0.0082	0.0171	0.0171
Trichomonas vaginalis	conserved hypothetical protein	0.0493	0.1213	0.1213
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0047	0.0047
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0108	0.0236	0.0236
Entamoeba histolytica	hypothetical protein	0.0255	0.061	0.061
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0021	0.0015	0.0015
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0748	0.186	0.186
Trichomonas vaginalis	CMGC family protein kinase	0.0064	0.0125	0.0125
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0047	0.0047
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0033	0.0047	0.0047
Onchocerca volvulus		0.0255	0.061	0.5
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0255	0.061	0.061
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.3956	1	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0255	0.061	0.061
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1327	0.3328	0.3328
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3378	0.8532	0.8532
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0255	0.061	0.061
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0255	0.061	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0255	0.061	0.061
Trichomonas vaginalis	immunophilin, putative	0.0108	0.0236	0.0236
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0255	0.061	0.0769
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0255	0.061	0.061
Echinococcus granulosus	voltage gated potassium channel	0.0021	0.0015	0.0015
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0255	0.061	0.061
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0023	0.002	0.002
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0748	0.186	0.186
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2942	0.7428	0.7428
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2136	0.5382	0.5382
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0255	0.061	0.061
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0255	0.061	0.061
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0255	0.061	0.061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3147	0.7946	0.7946
Loa Loa (eye worm)	hypothetical protein	0.0578	0.143	0.143
Leishmania major	hypothetical protein, unknown function	0.0255	0.061	0.061
Echinococcus multilocularis	serine:threonine protein kinase haspin	0.0082	0.0171	0.0171
Entamoeba histolytica	hypothetical protein	0.0255	0.061	0.061
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0255	0.061	0.061
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0255	0.061	0.061
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0108	0.0236	0.0236
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.0125	0.0125
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0748	0.186	0.186
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2136	0.5382	0.5382
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0255	0.061	0.061
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.3956	1	1
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0255	0.061	0.061
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0093	0.0198	0.0198
Schistosoma mansoni	serine/threonine-protein kinase	0.0023	0.002	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2942	0.7428	0.7428
Mycobacterium leprae	conserved hypothetical protein	0.0255	0.061	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.234	0.59	0.59
Leishmania major	peptidylprolyl isomerase-like protein	0.0108	0.0236	0.0236
Plasmodium vivax	hypothetical protein	0.0255	0.061	1
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0255	0.061	0.061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2133	0.5374	0.5374
Schistosoma mansoni	immunophilin	0.0108	0.0236	0.0236
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0255	0.061	0.061
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0255	0.061	0.061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2364	0.596	0.596
Trichomonas vaginalis	conserved hypothetical protein	0.0578	0.143	0.143
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0493	0.1213	0.1213
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0255	0.061	0.0769
Brugia malayi	Protein kinase domain containing protein	0.0033	0.0047	0.0047
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0255	0.061	0.061
Trypanosoma brucei	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.0064	0.0125	0.0125
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0108	0.0236	0.0236
Brugia malayi	hypothetical protein	0.0082	0.0171	0.0171
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0255	0.061	0.061
Loa Loa (eye worm)	hypothetical protein	0.0255	0.061	0.061
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0108	0.0236	0.5
Echinococcus granulosus	serine threonine protein kinase nrc	0.0021	0.0015	0.0015
Leishmania major	protein kinase, putative,dual-specificity protein kinase, putative	0.0064	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0834	0.2077	0.2077
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1327	0.3328	0.3328
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0108	0.0236	0.0236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1327	0.3328	0.3328
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0748	0.186	0.186
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0082	0.0171	0.0171
Giardia lamblia	GTOR	0.3956	1	1
Echinococcus granulosus	serine protein kinase ATM	0.0748	0.186	0.186
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0108	0.0236	0.0236
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.1327	0.3328	0.3328
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0255	0.061	0.061
Entamoeba histolytica	protein kinase rad3, putative	0.0748	0.186	0.186
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0021	0.0015	0.0015
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0255	0.061	0.061
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0122	0.0122
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0578	0.143	0.143
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0047	0.0047

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.5 uM	Inhibition of human recombinant N-terminal MBP-tagged haspin kinase expressed in Escherichia coli DE3 after 10 mins by TR-FRET assay	ChEMBL.	22335895
IC50 (binding)	= 4.8 uM	Inhibition of human N-terminal GST-tagged DYRK2 expressed in baculovirus using DYRKtide-F as substrate assessed as inhibition of [33P] incorporation into substrate using [gamma33P]ATP after 10 mins by liquid scintillation counting	ChEMBL.	22335895

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2012570

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1632776